leptin

Summary

Gene Symbol: leptin
Description: leptin
Alias: LEPD, OBS, leptin, leptin (murine obesity homolog), leptin (obesity homolog, mouse), obese protein, obese, mouse, homolog of, obesity factor
Species: human

Top Publications

  1. ncbi Leptin and the regulation of body weight in mammals
    J M Friedman
    Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021, USA
    Nature 395:763-70. 1998
  2. ncbi Positional cloning of the mouse obese gene and its human homologue
    Y Zhang
    Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021
    Nature 372:425-32. 1994
  3. ncbi Congenital leptin deficiency is associated with severe early-onset obesity in humans
    C T Montague
    University of Cambridge, Department of Medicine, UK
    Nature 387:903-8. 1997
  4. doi FoxO1 inhibits leptin regulation of pro-opiomelanocortin promoter activity by blocking STAT3 interaction with specificity protein 1
    Guoqing Yang
    Laboratory of Metabolic Medicine, Singapore Bioimaging Consortium, Agency for Science, Technology and Research, Singapore 138667
    J Biol Chem 284:3719-27. 2009
  5. ncbi Transcriptional activation of the human leptin gene in response to hypoxia. Involvement of hypoxia-inducible factor 1
    Grazia Ambrosini
    Department of Molecular Biology, Institute for Diabetes Discovery, 25 Business Park Drive, Branford, CT 06405, USA
    J Biol Chem 277:34601-9. 2002
  6. ncbi C-reactive protein in young, apparently healthy men: associations with serum leptin, QTc interval, and high-density lipoprotein-cholesterol
    Tsutomu Kazumi
    Department of Food Science and Nutrition, School of Human Environmental Science, Mukogawa Women s University, Health Science Center, Nishonomiya, Japan
    Metabolism 52:1113-6. 2003
  7. doi Association study of BMP4, IL6, Leptin, MMP3, and MTNR1B gene promoter polymorphisms and adolescent idiopathic scoliosis
    Mónika Mórocz
    Institute of Genetics, Biological Research Center, Hungarian Academy of Sciences, Temesvari korut 62, H 6726, Szeged, Hungary
    Spine (Phila Pa 1976) 36:E123-30. 2011
  8. doi Leptin enhances the recruitment of endothelial progenitor cells into neointimal lesions after vascular injury by promoting integrin-mediated adhesion
    Marco R Schroeter
    Department of Cardiology and Pulmonary Medicine, University of Goettingen, Robert Koch Strasse 40, D 37099 Goettingen, Germany
    Circ Res 103:536-44. 2008
  9. ncbi Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice
    H Chen
    Millennium Pharmaceuticals, Incorporated, Cambridge, Massachusetts 02139, USA
    Cell 84:491-5. 1996
  10. ncbi Effects of pro-inflammatory cytokines and chemokines on leptin production in human adipose tissue in vitro
    Jens M Bruun
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital and Faculty of Health Sciences, Aarhus University, Tage Hansensgade 2, Denmark
    Mol Cell Endocrinol 190:91-9. 2002

Research Grants

  1. Obese diabetic (type II) mouse model without leptin/leptin-receptor defects
    Richard G Peterson; Fiscal Year: 2013
  2. Medication Summary Guides for Vulnerable Populations with Rheumatoid Arthritis
    Edward H Yelin; Fiscal Year: 2010
  3. Leah S Karliner; Fiscal Year: 2014
  4. CLIFFORD JAMES ROSEN; Fiscal Year: 2015
  5. Technologically Enhanced Community Health Worker (CHW) Delivery of Personalized D
    MARY ELLEN MICHELE HEISLER; Fiscal Year: 2010
  6. Using Real-time Speech Translation for Medication Therapy Management of Spanish S
    FARZAD EHSANI; Fiscal Year: 2013
  7. Insulin Resistance in Tissue Specific IKKB Transgenics
    Jongsoon Lee; Fiscal Year: 2004
  8. Melissa A Kacena; Fiscal Year: 2015
  9. Subburaman Mohan; Fiscal Year: 2015
  10. Dean T Yamaguchi; Fiscal Year: 2016

Detail Information

Publications326 found, 100 shown here

  1. ncbi Leptin and the regulation of body weight in mammals
    J M Friedman
    Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021, USA
    Nature 395:763-70. 1998
    ..A complex physiological system has evolved to regulate fuel stores and energy balance at an optimum level. Leptin, a hormone secreted by adipose tissue, and its receptor are integral components of this system...
  2. ncbi Positional cloning of the mouse obese gene and its human homologue
    Y Zhang
    Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021
    Nature 372:425-32. 1994
    ..The ob gene product may function as part of a signalling pathway from adipose tissue that acts to regulate the size of the body fat depot...
  3. ncbi Congenital leptin deficiency is associated with severe early-onset obesity in humans
    C T Montague
    University of Cambridge, Department of Medicine, UK
    Nature 387:903-8. 1997
    The extreme obesity of the obese (ob/ob) mouse is attributable to mutations in the gene encoding leptin, an adipocyte-specific secreted protein which has profound effects on appetite and energy expenditure...
  4. doi FoxO1 inhibits leptin regulation of pro-opiomelanocortin promoter activity by blocking STAT3 interaction with specificity protein 1
    Guoqing Yang
    Laboratory of Metabolic Medicine, Singapore Bioimaging Consortium, Agency for Science, Technology and Research, Singapore 138667
    J Biol Chem 284:3719-27. 2009
    b>Leptin controls food intake and energy expenditure by regulating hypothalamic neuron activities...
  5. ncbi Transcriptional activation of the human leptin gene in response to hypoxia. Involvement of hypoxia-inducible factor 1
    Grazia Ambrosini
    Department of Molecular Biology, Institute for Diabetes Discovery, 25 Business Park Drive, Branford, CT 06405, USA
    J Biol Chem 277:34601-9. 2002
    In addition to having a major role in energy homeostasis, leptin is emerging as a pleiotropic cytokine with multiple physiological effector functions...
  6. ncbi C-reactive protein in young, apparently healthy men: associations with serum leptin, QTc interval, and high-density lipoprotein-cholesterol
    Tsutomu Kazumi
    Department of Food Science and Nutrition, School of Human Environmental Science, Mukogawa Women s University, Health Science Center, Nishonomiya, Japan
    Metabolism 52:1113-6. 2003
    ..Although CRP was positively correlated with body mass index (BMI), percent fat mass, and serum leptin, correlations with BMI (r = 0.15, P =.05) and percent body fat (r = 0.16, P =...
  7. doi Association study of BMP4, IL6, Leptin, MMP3, and MTNR1B gene promoter polymorphisms and adolescent idiopathic scoliosis
    Mónika Mórocz
    Institute of Genetics, Biological Research Center, Hungarian Academy of Sciences, Temesvari korut 62, H 6726, Szeged, Hungary
    Spine (Phila Pa 1976) 36:E123-30. 2011
    ..a genetic association study was performed on 126 patients with adolescent idiopathic scoliosis and 197 healthy controls from independent Hungarian pedigrees...
  8. doi Leptin enhances the recruitment of endothelial progenitor cells into neointimal lesions after vascular injury by promoting integrin-mediated adhesion
    Marco R Schroeter
    Department of Cardiology and Pulmonary Medicine, University of Goettingen, Robert Koch Strasse 40, D 37099 Goettingen, Germany
    Circ Res 103:536-44. 2008
    The adipocytokine leptin modulates vascular remodeling and neointima formation. Because endothelial progenitor cells (EPCs) participate in vascular repair, we analyzed the effects of leptin on human EPC function in vitro and in vivo...
  9. ncbi Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice
    H Chen
    Millennium Pharmaceuticals, Incorporated, Cambridge, Massachusetts 02139, USA
    Cell 84:491-5. 1996
    OB-R is a high affinity receptor for leptin, an important circulating signal for the regulation of body weight. We identified an alternatively spliced transcript that encodes a form of mouse OB-R with a long intracellular domain...
  10. ncbi Effects of pro-inflammatory cytokines and chemokines on leptin production in human adipose tissue in vitro
    Jens M Bruun
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital and Faculty of Health Sciences, Aarhus University, Tage Hansensgade 2, Denmark
    Mol Cell Endocrinol 190:91-9. 2002
    b>Leptin is synthesized in adipocytes and acts primarily through central pathways suppressing appetite and increasing the metabolic rate in rodents as well as in humans...
  11. ncbi Leptin promotes differentiation and survival of human dendritic cells and licenses them for Th1 priming
    Benedetta Mattioli
    Department of Drug Research and Evaluation, Istituto Superiore di Sanita, Rome, Italy
    J Immunol 174:6820-8. 2005
    b>Leptin is an adipocyte-derived hormone/cytokine that links nutrition, metabolism, and immune homeostasis. Leptin is capable of modulating several immune responses...
  12. ncbi OB-BP1/Siglec-6. a leptin- and sialic acid-binding protein of the immunoglobulin superfamily
    N Patel
    Molecular Biology Department, DNAX Research Institute, Palo Alto, California 94304, USA
    J Biol Chem 274:22729-38. 1999
    We report the expression cloning of a novel leptin-binding protein of the immunoglobulin superfamily (OB-BP1) and a cross-hybridizing clone (OB-BP2) that is identical to a recently described sialic acid-binding I-type lectin called Siglec-..
  13. doi Association of leptin -2548G/A and leptin receptor Q223R polymorphisms with increased risk for oral cancer
    Christos Yapijakis
    Department of Oral and Maxillofacial Surgery, University of Athens Medical School, Kifissias and Perikleous Stavrou 9, 11524, Athens, Greece
    J Cancer Res Clin Oncol 135:603-12. 2009
    We investigated the possible association of DNA polymorphisms -2548G/A and Q223R in the leptin (LEP) and leptin receptor (LEPR) genes, respectively, which both affect the amount of circulating cytokine-type hormone leptin, with risk for ..
  14. doi Association of plasma leptin levels and insulin resistance in diabetic women: a cross-sectional analysis in an Iranian population with different results in men and women
    Manouchehr Nakhjavani
    Endocrinology and Metabolism Research Center, Vali Asr Hospital, School of Medicine, Medical Sciences University of Tehran, Tehran, Iran
    Gynecol Endocrinol 27:14-9. 2011
    The objective of this study was to assess the association of serum leptin levels with insulin resistance (IR), metabolic syndrome (MetS), lipid levels, and glucose control in an Iranian type 2 diabetic population.
  15. ncbi Hypoxia-inducible factor 1 transactivates the human leptin gene promoter
    Alexandra Grosfeld
    INSERM U 465, Centre de Recherche des Cordeliers, Universite Pierre et Marie Curie, 15 rue de l Ecole de Medecine, 75006 Paris, France
    J Biol Chem 277:42953-7. 2002
    Increased placental leptin has been demonstrated in preeclampsia, a pregnancy disorder associated with placental hypoxia. This suggests that leptin gene expression is enhanced in response to oxygen deficiency in this organ...
  16. ncbi The formation of an intrachain disulfide bond in the leptin protein is necessary for efficient leptin secretion
    N Boute
    Department of Cell Biology, Institut Cochin, UMR CNRS 8104, INSERM U567, Universite Paris 5, 22, Rue Mechain, 75014 Paris, France
    Biochimie 86:351-6. 2004
    b>Leptin is a cytokine secreted by the adipose tissue that is involved in the control of body weight...
  17. ncbi Relationship between leptin, insulin resistance, insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in patients with chronic kidney disease
    A Atamer
    Department of Internal Medicine, Diyarbakir Training and Research Hospital, Diyarbakir, Turkey
    J Int Med Res 36:522-8. 2008
    This study examined the relationship between leptin, insulin-like growth factor-1 (IGF-1), IGF binding protein-3 (IGFBP-3) and insulin resistance in patients with chronic kidney disease (CKD)...
  18. doi Human paraoxonase-1 activity in childhood obesity and its relation to leptin and adiponectin levels
    Peter Koncsos
    First Department of Medicine, University of Debrecen, Debrecen, Hungary
    Pediatr Res 67:309-13. 2010
    ..Alterations and potential correlations of PON1 activities, leptin and adiponectin levels in childhood obesity were studied...
  19. doi Leptin-R and its association with PI3K/AKT signaling pathway in papillary thyroid carcinoma
    Shahab Uddin
    Department of Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Endocr Relat Cancer 17:191-202. 2010
    The putative role of leptin and its receptor (Ob-R) in the pathogenesis of various primary human malignancies has been reported; however, their role in papillary thyroid cancer (PTC) has not yet been evaluated...
  20. doi Genetic variations of leptin and leptin receptor are associated with body composition changes in response to physical training
    Antti Huuskonen
    Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland
    Cell Biochem Funct 28:306-12. 2010
    b>Leptin regulates body weight, metabolism, and tissue adaptations to environmental stressors...
  21. doi The peritoneal leptin, MCP-1 and TNF-α in the pathogenesis of endometriosis-associated infertility
    Yu Tao
    Department of Obstetrics Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China
    Am J Reprod Immunol 65:403-6. 2011
    To explore the roles of leptin, monocyte chemotactic protein (MCP)-1, and tumour necrosis factor (TNF)-α in the peritoneal fluid (PF) in the pathogenesis of endometriosis-associated infertility.
  22. pmc Development and characterization of high affinity leptins and leptin antagonists
    Michal Shpilman
    Robert H Smith Faculty of Agriculture, Food and Environment, Hebrew University, Rehovot 76100, Israel
    J Biol Chem 286:4429-42. 2011
    b>Leptin is a pleiotropic hormone acting both centrally and peripherally. It participates in a variety of biological processes, including energy metabolism, reproduction, and modulation of the immune response...
  23. pmc Leptin, obestatin and apelin levels in patients with obstructive sleep apnoea syndrome
    Sabine Zirlik
    Medical Department 1, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Med Sci Monit 17:CR159-64. 2011
    Recent studies suggest that adipose tissue hormones are involved in the pathogenesis of obstructive sleep apnoea syndrome (OSAS). The role of leptin, obestatin and apelin still needs to be established.
  24. doi Association between the chondrocyte phenotype and the expression of adipokines and their receptors: evidence for a role of leptin but not adiponectin in the expression of cartilage-specific markers
    Pierre Jean Francin
    UMR CNRS UHP 7561, Faculte de Medecine, Vandoeuvre les Nancy, France
    J Cell Physiol 226:2790-7. 2011
    ..The expression of leptin, adiponectin and their receptors, as well as cartilage-specific genes was examined in chondrocytes obtained from ..
  25. pmc Influence of leptin, adiponectin, and resistin on the association between abdominal adiposity and arterial stiffness
    B Gwen Windham
    Department of Internal Medicine, Division of Geriatric Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA
    Am J Hypertens 23:501-7. 2010
    ..adipocytes account for most adipokine production, the objectives of this study were to examine the influence of adipokines such as leptin, adiponectin, and resistin on the relationship between abdominal adiposity and arterial stiffness.
  26. ncbi Body fat mass and macronutrient intake in relation to circulating soluble leptin receptor, free leptin index, adiponectin, and resistin concentrations in healthy humans
    Mary Yannakoulia
    Department of Nutrition Dietetics, Harokopio University, 17671 Athens, Greece
    J Clin Endocrinol Metab 88:1730-6. 2003
    The adipocyte-derived hormones leptin [which circulates in a free form and bound to a soluble leptin receptor (sOB-R)], adiponectin, and resistin play a key role in regulating energy homeostasis and metabolism...
  27. doi The -2548G/A LEP polymorphism is associated with blood pressure in Tunisian obese patients
    S Ben Ali
    Research Laboratory LAB SM 01, Biochemistry Department, Rabta Hospital, Tunis, Tunisia
    Blood Press 17:278-83. 2008
    To examine the association of a common -2548G/A (rs7799039) promoter variant of the human leptin gene (LEP) with obesity or body mass index (BMI) and its associated phenotypes such as blood pressure variability and the prevalence of ..
  28. doi Leptin prevents apoptosis of trophoblastic cells by activation of MAPK pathway
    Antonio Pérez-Pérez
    Departamento de Bioquimica Medica y Biologia Molecular, Facultad de Medicina Hospital Universitario Virgen Macarena, Universidad de Sevilla, Espana, Spain
    Arch Biochem Biophys 477:390-5. 2008
    b>Leptin (Ob), the peripheral signal produced by the adipocyte to regulate energy metabolism, can also be produced by placenta, where it may work as an autocrine hormone...
  29. ncbi Leptin suppresses stearoyl-CoA desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c
    Sudha B Biddinger
    Research Division, Joslin Diabetes Center, One Joslin Pl, Boston, MA 02215, USA
    Diabetes 55:2032-41. 2006
    ..SCD1 is suppressed by leptin but induced by insulin. We have used animal models to dissect the effects of these hormones on SCD1...
  30. ncbi Serum leptin levels correlate with interleukin-6 levels and disease activity in patients with ankylosing spondylitis
    M C Park
    Division of Rheumatology, Department of Internal Medicine, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, Korea
    Scand J Rheumatol 36:101-6. 2007
    To determine whether serum leptin levels are elevated in men with ankylosing spondylitis (AS) and whether the levels correlate with serum cytokine profiles and disease activity of AS.
  31. ncbi Regulation of circulating soluble leptin receptor levels by gender, adiposity, sex steroids, and leptin: observational and interventional studies in humans
    Jean L Chan
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Avenue, Boston, MA 02215, USA
    Diabetes 51:2105-12. 2002
    b>Leptin is an adipocyte-secreted hormone important in energy homeostasis and diverse physiological processes...
  32. doi Up-regulation of placental leptin by human chorionic gonadotropin
    Julieta L Maymó
    Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Universidas de Buenos Aires, Buenos Aires, Argentina
    Endocrinology 150:304-13. 2009
    b>Leptin, the 16,000 molecular weight protein product of the obese gene, was originally considered as an adipocyte-derived signaling molecule for the central control of metabolism...
  33. doi Are the associations of plasma leptin and adiponectin with type 2 diabetes independent of obesity in older Chinese adults?
    Zhiqiang Wang
    Centre for Chronic Disease, School of Medicine, University of Queensland, Herston, QLD 4029, Australia
    Diabetes Metab Res Rev 26:109-14. 2010
    China has experienced a rapid increase in diabetes. In this study, we assessed whether the associations of two adipocyte-derived hormones, leptin and adiponectin, with type 2 diabetes are independent of obesity in older Chinese adults.
  34. pmc Serum leptin is associated with cardiometabolic risk and predicts metabolic syndrome in Taiwanese adults
    Wen Cheng Li
    Department of Occupation Medicine, Chang Gung Memorial Hospital, Keelung Branch, NO, 222, Maijin Rd, Keelung, Taiwan
    Cardiovasc Diabetol 10:36. 2011
    b>Leptin is associated with cardiovascular disease (CVD); however, few studies have assessed its relationship with metabolic syndrome, especially in an Asian population...
  35. ncbi Leptin enhances, via AP-1, expression of aromatase in the MCF-7 cell line
    Stefania Catalano
    Centro Sanitario and the Department of PharmacoBiology, Faculty of Pharmacy, University of Calabria, 87030 Arcavacata di Rende, Italy
    J Biol Chem 278:28668-76. 2003
    b>Leptin, a product of adipocytes, is involved in the regulation of body weight and results strongly correlated to body fat content...
  36. pmc Leptin and its receptor are overexpressed in brain tumors and correlate with the degree of malignancy
    Mirko Riolfi
    Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, PA 19122, USA
    Brain Pathol 20:481-9. 2010
    Although leptin and its receptor (ObR) have emerged as important cancer biomarkers, the role of the leptin system in brain tumor development remains unknown...
  37. ncbi Leptin induces endothelin-1 in endothelial cells in vitro
    Peter Quehenberger
    Department of Medical and Chemical Laboratory Diagnostics, University of Vienna, Austria
    Circ Res 90:711-8. 2002
    b>Leptin, a protein encoded by the obese gene, is produced by adipocytes and released into the bloodstream. In obese humans, serum leptin levels are increased and correlate with the individual's body mass index and blood pressure...
  38. ncbi Leptin receptor and functional effects of leptin in human endothelial progenitor cells
    Robert Wolk
    Mayo Foundation, St Mary s Hospital, DO 4 350, 1216 Second St SW, Rochester, MN 55902, USA
    Atherosclerosis 183:131-9. 2005
    ..We studied the role of an adipocyte-derived hormone, leptin, in the regulation of human EPC function. EPCs were grown from human circulating mononuclear cells...
  39. doi Leptin utilizes Jun N-terminal kinases to stimulate the invasion of MCF-7 breast cancer cells
    Vanity McMurtry
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, USA
    Clin Exp Metastasis 26:197-204. 2009
    In breast tumors, high levels of leptin have been associated with increased incidence of breast cancer metastasis. Breast cancer metastasis is directly associated with breast cancer cell invasion...
  40. doi Leptin receptor expression in Middle Eastern colorectal cancer and its potential clinical implication
    Shahab Uddin
    Human Cancer Genomic Research, Research Centre, Saudi Arabia
    Carcinogenesis 30:1832-40. 2009
    We investigated the role of leptin receptor (Ob-R) and its relationship with phosphatidylinositol 3-kinase (PI3K)/AKT activation in colorectal carcinomas (CRCs) tissues followed by in vitro studies using a panel of CRC cell lines...
  41. ncbi Circulating leptin and angiogenic factors in preeclampsia patients
    Hideki Nakatsukasa
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Endocr J 55:565-73. 2008
    b>Leptin, one of adipocytokines, plays a wide range of important roles in reproductive biology. We have previously reported that low hypo-adiponectinemia might be involved in the pathophysiology of overweight preeclampsia (PE) patients...
  42. doi Mechanism of the inhibitory effect of atorvastatin on leptin expression induced by angiotensin II in cultured human coronary artery smooth muscle cells
    Kou Gi Shyu
    Division of Cardiology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Clin Sci (Lond) 122:33-42. 2012
    b>Leptin contributes to the pathogenesis of atherosclerosis. Ang II (angiotensin II), a proatherogenic cytokine, increases leptin synthesis in cultured adipocytes...
  43. pmc Differential signalling through ALK-1 and ALK-5 regulates leptin expression in mesenchymal stem cells
    Mustapha Zeddou
    Laboratory of Rheumatology, GIGA I3, GIGA Research Centre, University and CHU of Liege, Liege, Belgium
    Stem Cells Dev 21:1948-55. 2012
    b>Leptin plays a central role in maintaining energy balance, with multiple other systemic effects...
  44. ncbi Leptin and its soluble receptor in plasma of patients suffering from remitting-relapsing multiple sclerosis (MS) In vitro effects of leptin on type-1 and type-2 cytokine secretion by peripheral blood mononuclear cells, T-cells and monocytes of MS patients
    Kokona Chatzantoni
    Experimental Hematology and Transfusion Medicine, Medical School and University Hospital, University of Patras, Patras, Greece
    J Autoimmun 23:169-77. 2004
    b>Leptin is synthesized by adipocytes to regulate appetite. Leptin has also been implicated in the pathogenesis of multiple sclerosis (MS) leading to speculation about a beneficial effect of fasting to autoimmune patients...
  45. doi Insulin resistance, leptin and monocyte chemotactic protein-1 levels in diabetic and non-diabetic Afro-Caribbean subjects
    C E Ezenwaka
    The University of the West Indies, St Augustine, Trinidad
    Arch Physiol Biochem 115:22-7. 2009
    To determine how the levels of leptin and monocyte chemotactic protein-1 (MCP-1) are associated with insulin resistance (IR) in obese, non-obese, diabetic and non-diabetic subjects.
  46. pmc Induction of insulin resistance by the adipokines resistin, leptin, plasminogen activator inhibitor-1 and retinol binding protein 4 in human megakaryocytes
    Anja J Gerrits
    Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The Netherlands
    Haematologica 97:1149-57. 2012
    ..Platelet from patients with type 2 diabetes are resistant to insulin and show increased Ca(2+) mobilization, aggregation and procoagulant activity. We searched for the cause of this insulin resistance...
  47. pmc Corticotropin-releasing hormone stimulates expression of leptin, 11beta-HSD2 and syncytin-1 in primary human trophoblasts
    Fabian B Fahlbusch
    Department of Pediatrics and Adolescent Medicine, University of Erlangen Nurnberg, Erlangen, Germany
    Reprod Biol Endocrinol 10:80. 2012
    ..Intrauterine growth restriction (IUGR) is accompanied by an increase in placental CRH, which could be of pathophysiological relevance for the dysregulation in syncytialisation seen in IUGR placentas...
  48. ncbi Leptin and insulin down-regulate angiopoietin-like protein 3, a plasma triglyceride-increasing factor
    Mitsuru Shimamura
    Biomedical Research Laboratories, Sankyo Co, Ltd, 1 2 58 Hiromachi, Shinagawa ku, Tokyo 140 8710, Japan
    Biochem Biophys Res Commun 322:1080-5. 2004
    ..The current study examined the regulation of Angptl3 by leptin and insulin, both of which are key players in the metabolic syndrome...
  49. ncbi Association of plasma leptin levels and complexity of the culprit lesion in patients with unstable angina
    Laxman Dubey
    Department of Cardiology, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology HUST, Wuhan 430030, Hubei, PR China
    Int J Cardiol 126:183-9. 2008
    ..By activating different immune/inflammatory cells or directly acting on the vessel wall leptin has been shown to play a potential role in the development of acute coronary syndrome...
  50. pmc Circulating ghrelin, leptin, and soluble leptin receptor concentrations and cardiometabolic risk factors in a community-based sample
    Erik Ingelsson
    The Framingham Study, Boston University School of Medicine, Framingham, Massachusetts 01702 5803, USA
    J Clin Endocrinol Metab 93:3149-57. 2008
    The conjoint effects and relative importance of ghrelin, leptin, and soluble leptin receptor (sOB-R), adipokines involved in appetite control and energy expenditure in mediating cardiometabolic risk, is unknown.
  51. pmc DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific
    Elmar W Tobi
    Molecular Epidemiology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands
    Hum Mol Genet 18:4046-53. 2009
    ..017). Our data indicate that persistent changes in DNA methylation may be a common consequence of prenatal famine exposure and that these changes depend on the sex of the exposed individual and the gestational timing of the exposure...
  52. doi The Q223R polymorphism in LEPR is associated with obesity in Pacific Islanders
    Takuro Furusawa
    Asian Studies Network ASNET, Division for International Relations, The University of Tokyo, Tokyo, Japan
    Hum Genet 127:287-94. 2010
    ..This study examined the association of a promoter polymorphism of the leptin gene (LEP), G-2548A (rs7799039), and two non-synonymous single nucleotide polymorphisms of the leptin receptor ..
  53. ncbi Human obese gene expression. Adipocyte-specific expression and regional differences in the adipose tissue
    H Masuzaki
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Japan
    Diabetes 44:855-8. 1995
    ..This study is the first report of the elucidation of ob gene expression in human tissues, thereby leading to better understanding of the physiological and clinical implications of the ob gene...
  54. ncbi Overexpressing leptin genetic polymorphism (-2548 G/A) is associated with susceptibility to prostate cancer and risk of advanced disease
    Ricardo Ribeiro
    Molecular Oncology Unit, Instituto Portugues de Oncologia, Porto, Portugal
    Prostate 59:268-74. 2004
    b>Leptin has been consistently associated with angiogenesis and tumoral growth. A G/A single nucleotide polymorphism (SNP) at the -2548 site in leptin gene (LEP) is associated with overexpression of leptin (A-allele).
  55. ncbi A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
    K Clement
    Laboratoire de Nutrition et Service de Médecine et Nutrition, Hôtel Dieu place du Parvis Notre Dame, Paris, France
    Nature 392:398-401. 1998
    The adipocyte-specific hormone leptin, the product of the obese (ob) gene, regulates adipose-tissue mass through hypothalamic effects on satiety and energy expenditure...
  56. ncbi The human obese (OB) gene: RNA expression pattern and mapping on the physical, cytogenetic, and genetic maps of chromosome 7
    E D Green
    Diagnostic Development Branch, National Center for Human Genome Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genome Res 5:5-12. 1995
    ....
  57. ncbi Leptin increases proliferation of human steosarcoma cells through activation of PI(3)-K and MAPK pathways
    Bartolome Burguera
    Division of Endocrinology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Med Sci Monit 12:BR341-9. 2006
    Serum leptin levels are strongly and directly related to fat body mass (FBM). Bone mineral density (BMD) increases with FBM, and obesity has a protective effect against osteoporosis...
  58. ncbi Decreased circulating leptin level and its association with body and bone mass in girls with adolescent idiopathic scoliosis
    Yong Qiu
    Spine Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
    Spine (Phila Pa 1976) 32:2703-10. 2007
    A prospective study was designed to investigate the circulating leptin level in girls with adolescent idiopathic scoliosis (AIS).
  59. ncbi Leptin gene expression in human preadipocytes is switched on by maturation-induced demethylation of distinct CpGs in its proximal promoter
    Ingo Melzner
    Department of Pathology, University of Ulm, Albert Einstein Allee 11, D 89081 Ulm, Germany
    J Biol Chem 277:45420-7. 2002
    The peptide hormone leptin plays a major role in the regulation of energy intake and expenditure and is predominantly expressed in mature adipocytes but not in preadipocytes...
  60. ncbi Human leptin locus (LEP) alleles and BMI in Samoans
    S T McGarvey
    International Health Institute, Brown Medical School, Providence, Rhode Island, USA
    Int J Obes Relat Metab Disord 26:783-8. 2002
    ....
  61. ncbi Leptin gene polymorphism is associated with hypertension independent of obesity
    Maki Shintani
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Clin Endocrinol Metab 87:2909-12. 2002
    b>Leptin is an adipocyte-derived hormone that regulates food intake and energy expenditure. Recent functional studies have suggested a direct effect of leptin on blood pressure...
  62. ncbi Weight loss increases soluble leptin receptor levels and the soluble receptor bound fraction of leptin
    Markus Laimer
    Department of Medicine, University of Innsbruck, Austria
    Obes Res 10:597-601. 2002
    Soluble leptin receptor (sOB-R) represents the main binding site for leptin in human blood...
  63. ncbi Diurnal and ultradian dynamics of serum adiponectin in healthy men: comparison with leptin, circulating soluble leptin receptor, and cortisol patterns
    Alina Gavrila
    Division of Endocrinology and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Clin Endocrinol Metab 88:2838-43. 2003
    ..rhythms in healthy normal-weight men and to compare the 24-h profile of adiponectin fluctuations with those of leptin, leptin-binding protein (sOB-R), and cortisol...
  64. ncbi Leptin induces, via ERK1/ERK2 signal, functional activation of estrogen receptor alpha in MCF-7 cells
    Stefania Catalano
    Centro Sanitario, University of Calabria, Arcavacata di Rende, Cosenza 87030, Italy
    J Biol Chem 279:19908-15. 2004
    b>Leptin is a hormone with multiple biological actions, produced predominantly by adipose tissue. In humans, plasma levels correlate with total body fat, and high concentrations occur in obese women...
  65. ncbi Body mass index, leptin and leptin receptor polymorphisms, and non-hodgkin lymphoma
    Christine F Skibola
    Division of Environmental Health Sciences, School of Public Health, 140 Earl Warren Hall, University of California, Berkeley, CA 94720 7360, USA
    Cancer Epidemiol Biomarkers Prev 13:779-86. 2004
    ..Obesity-related genetic factors including common polymorphisms in the leptin gene (LEP A19G and G-2548A) and its receptor (LEPR Q223R) were investigated in DNA available for 376 patients and ..
  66. ncbi Leptin hormonal kinetics in the fed state: effects of adiposity, age, and gender on endogenous leptin production and clearance rates
    Shekman L Wong
    Department of Pharmacokinetics and Drug Metabolism, Amgen Inc, Thousand Oaks, California 91320, USA
    J Clin Endocrinol Metab 89:2672-7. 2004
    b>Leptin is an adipocyte-secreted hormone that regulates energy homeostasis and neuroendocrine function...
  67. ncbi Plasma leptin levels are associated with coronary atherosclerosis in type 2 diabetes
    Muredach P Reilly
    Cardiovascular Division, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, USA
    J Clin Endocrinol Metab 89:3872-8. 2004
    b>Leptin signaling may promote atherothrombosis and lead to cardiovascular disease. However, whether leptin is associated with human atherosclerosis, distinct from thrombosis, is unknown...
  68. ncbi Luminal leptin induces rapid inhibition of active intestinal absorption of glucose mediated by sodium-glucose cotransporter 1
    Robert Ducroc
    Institut National de la Santé et de la Recherche Médicale Unité 410, IFR02 Claude Bernard, Faculte de Medecine Xavier Bichat, Paris, France
    Diabetes 54:348-54. 2005
    The effect of leptin on glucose transport was studied in rat jejunal mucosa in Ussing chambers. Leptin was added in the luminal or the serosal compartment before the tissues were challenged with 1, 10, or 50 mmol/l glucose...
  69. ncbi Influence of nutritional recovery on the leptin axis in severely malnourished children
    Katja Stein
    Institute of Nutrition, Friedrich Schiller University, Dornburger Strasse 24, D 07743 Jena, Germany
    J Clin Endocrinol Metab 91:1021-6. 2006
    b>Leptin might be more important as a starvation hormone than as a satiety signal. The role of the soluble leptin receptor (sOB-R) and its regulation in children with protein energy malnutrition (PEM) is poorly understood.
  70. ncbi Leptin predicts the development of diabetes in Mauritian men, but not women: a population-based study
    S Soderberg
    International Diabetes Institute, Melbourne, Australia
    Int J Obes (Lond) 31:1126-33. 2007
    To determine if levels of the adipocyte-derived hormone, leptin, predict the development of type 2 diabetes.
  71. ncbi Differential expression of leptin and leptin's receptor isoform (Ob-Rb) mRNA between advanced and minimally affected osteoarthritic cartilage; effect on cartilage metabolism
    T Simopoulou
    Department of Biology, University of Thessalia, Medical School, Larissa, Greece
    Osteoarthritis Cartilage 15:872-83. 2007
    To investigate leptin's effect on cartilage metabolism and the pathophysiology of osteoarthritis (OA).
  72. ncbi Expression of the obesity hormone leptin and its receptor correlates with hypoxia-inducible factor-1 alpha in human colorectal cancer
    M Koda
    Department of Pathomorphology, Medical University of Bialystok, Bialystok, Poland
    Ann Oncol 18:vi116-9. 2007
    The obesity hormone, leptin, has been found to play a role in development and proliferation of normal and malignant tissues...
  73. ncbi Leptin and coronary heart disease risk: prospective case control study of British women
    Debbie A Lawlor
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
    Obesity (Silver Spring) 15:1694-701. 2007
    Prospective studies have shown a positive association between leptin concentrations and coronary heart disease (CHD) in men, but its effect in women is unclear...
  74. ncbi IGF-1 and leptin associate with fetal HDL cholesterol at birth: examination in offspring of mothers with type 1 diabetes
    Scott M Nelson
    Department of Reproductive and Maternal Medicine, Division of Developmental Medicine, University of Glasgow, Glasgow Royal Infirmary, 10 Alexandra Parade, Glasgow, G31 ER, UK
    Diabetes 56:2705-9. 2007
    ..We examined the influence of maternal diabetes on cord lipids at birth and relationship to body composition, cord insulin, leptin, and other hormonal measures.
  75. ncbi Contribution of leptin receptor N-linked glycans to leptin binding
    Yuichi Kamikubo
    Roon Research Center for Arteriosclerosis and Thrombosis, Division of Blood Cell and Vascular Biology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Biochem J 410:595-604. 2008
    The extracellular domain of the human leptin receptor (Ob-R) contains 20 potential N-glycosylation sites whose role in leptin binding remains to be elucidated...
  76. doi Expression of leptin and its functional receptor on disc cells: contribution to cell proliferation
    Chang Qing Zhao
    Department of Orthopaedic Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Spine (Phila Pa 1976) 33:E858-64. 2008
    ..Human herniated disc tissues and rat nucleus pulposus (NP) cells were used following approval by the authors' institutional Human Ethics Review Committee and Animal Care and Use Committee...
  77. doi Serum leptin, adiponectin, and resistin concentration in colorectal adenoma and carcinoma (CC) patients
    Anna Kumor
    Department of Laboratory Diagnostics, Medical University, Lodz, Poland
    Int J Colorectal Dis 24:275-81. 2009
    b>Leptin, adiponectin, and resistin are the proteins secreted by adipocytes, which affects the metabolism. While the role of leptin in colon carcinogenesis is documented, the effect of adiponectin and resistin remains unclear...
  78. doi Association of G-2548A LEP polymorphism with plasma leptin levels in Tunisian obese patients
    Samir Ben Ali
    Biochemistry Department, Research Laboratory LR99ES11, Rabta Hospital, Tunis, Tunisia
    Clin Biochem 42:584-8. 2009
    The aim of this study was to examine the association of the G-2548A polymorphism of the human leptin gene (LEP) with body mass index (BMI), plasma leptin, insulin, and lipid parameters in a sample of Tunisian population.
  79. pmc The ambiguous role of the Na+-H+ exchanger isoform 1 (NHE1) in leptin-induced oxidative stress in human monocytes
    Diamantis Konstantinidis
    Laboratory of Animal Physiology, School of Biology, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece
    Cell Stress Chaperones 14:591-601. 2009
    b>Leptin, a 16-kDa cytokine produced mainly by the adipose tissue, is known to increase energy expenditure while at the same time lowering food intake by acting directly on the hypothalamus...
  80. ncbi A leptin missense mutation associated with hypogonadism and morbid obesity
    A Strobel
    Nat Genet 18:213-5. 1998
  81. ncbi Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
    Yasuhiko Minokoshi
    Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Nature 415:339-43. 2002
    b>Leptin is a hormone secreted by adipocytes that plays a pivotal role in regulating food intake, energy expenditure and neuroendocrine function...
  82. ncbi Increased leptin expression in endometriosis cells is associated with endometrial stromal cell proliferation and leptin gene up-regulation
    Meng Hsing Wu
    Institute of Clinical Medicine and Department of Obstetrics and Gynecology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan, ROC
    Mol Hum Reprod 8:456-64. 2002
    ..b>Leptin is the product of the ob gene, which is related to reproductive function and immunological alteration...
  83. pmc Distribution of the long leptin receptor isoform in brush border, basolateral membrane, and cytoplasm of enterocytes
    J Barrenetxe
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    Gut 50:797-802. 2002
    b>Leptin, a hormone mainly produced by fat cells, acts primarily on the hypothalamus regulating energy expenditure and food intake...
  84. ncbi A polymorphism in the leptin promoter region (-2548 G/A) influences gene expression and adipose tissue secretion of leptin
    J Hoffstedt
    Department of Medicine at Huddinge University Hospital, Stockholm, Sweden
    Horm Metab Res 34:355-9. 2002
    There is a large inter-individual variation in circulating leptin concentrations at each level of body fat content. The reason for this is unknown...
  85. pmc Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency
    I Sadaf Farooqi
    University Department of Medicine, Department of Clinical Biochemistry, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Clin Invest 110:1093-103. 2002
    The wide range of phenotypic abnormalities seen in the leptin-deficient ob/ob mouse and their reversibility by leptin administration provide compelling evidence for the existence of multiple physiological functions of this hormone in ..
  86. ncbi Polymorphisms in candidate obesity genes and their interaction with dietary intake of n-6 polyunsaturated fatty acids affect obesity risk in a sub-sample of the EPIC-Heidelberg cohort
    Alexandra Nieters
    German Cancer Research Center, Division of Clinical Epidemiology, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Eur J Nutr 41:210-21. 2002
    ....
  87. ncbi Plasma leptin and blood pressure in men: graded association independent of body mass and fat pattern
    Gianvincenzo Barba
    Epidemiology and Population Genetics, Institute of Food Science, National Research Council, Avellino, Italy
    Obes Res 11:160-6. 2003
    The role of leptin in the association between body mass, central adiposity, and blood pressure (BP) is controversial...
  88. ncbi Leptin regulation of the interleukin-1 system in human endometrial cells
    Ruben Rene Gonzalez
    Boston Biomedical Research Institute, 64 Grove Street, Watertown, MA 02472, USA
    Mol Hum Reprod 9:151-8. 2003
    We have previously shown that (i). leptin and leptin receptor (Ob-R) are expressed in the human endometrium, and (ii). leptin secretion is regulated in blastocyst and endometrial epithelial cell (EEC) co-cultures...
  89. ncbi Systemic inflammation, adipose tissue tumor necrosis factor, and leptin expression
    Monica Bullo
    Unitat de Nutricio Humana, Facultat de Medicina i Ciencies de la Salut de Reus, Universitat Rovira i Virgili, Reus, Spain
    Obes Res 11:525-31. 2003
    To explore the links between tumor necrosis factor alpha (TNFalpha) and leptin adipose tissue expression and low-grade systemic inflammation and to determine the relationship between inflammation and the degree of adiposity, the presence ..
  90. ncbi Changes in circulating leptin, leptin receptor, and gonadal hormones from infancy until advanced age in humans
    David R Mann
    Cooperative Reproductive Science Research Center and Department of Physiology, Morehouse School of Medicine, Atlanta, Georgia 30310, USA
    J Clin Endocrinol Metab 88:3339-45. 2003
    We determined developmental changes in circulating levels of the soluble leptin receptor (sOB-R), leptin, and gonadal hormones in human subjects...
  91. ncbi Leptin: a potential marker of placental insufficiency
    Jacques Lepercq
    Service de Gynecologie Obstetrique, Hopital Cochin Saint Vincent de Paul, Paris, France
    Gynecol Obstet Invest 55:151-5. 2003
    To investigate placental leptin production in placental insufficiency, placental leptin production was measured in women with severe preeclampsia (group 1) and in normotensive pregnancies associated with intrauterine growth restriction (..
  92. ncbi Leptin indirectly activates human neutrophils via induction of TNF-alpha
    Hamid Zarkesh-Esfahani
    Division of Clinical Sciences North, University of Sheffield, Sheffield, United Kingdom
    J Immunol 172:1809-14. 2004
    b>Leptin, the satiety hormone, appears to act as a link between nutritional status and immune function...
  93. ncbi Do adiponectin, TNFalpha, leptin and CRP relate to insulin resistance in pregnancy? Studies in women with and without gestational diabetes, during and after pregnancy
    Kylie A McLachlan
    Department of Endocrinology, St Vincents Hospital, Victoria, Australia
    Diabetes Metab Res Rev 22:131-8. 2006
    The role of adiponectin, tumour necrosis factor alpha (TNFalpha), leptin and C-reactive protein in the insulin resistance of pregnancy is not clear...
  94. ncbi Peritoneal fluid leptin is associated with chronic pelvic pain but not infertility in endometriosis patients
    Mohamed A Bedaiwy
    Center for Advanced Research in Human Reproduction, Infertility, and Sexual Function, Department of Obstetrics Gynecology, Urological Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Hum Reprod 21:788-91. 2006
    b>Leptin influences the proinflammatory immune responses and has angiogenic activity in vitro and in vivo...
  95. ncbi Leptin and its receptors in human fetal and adult ovaries
    Ronit Abir
    Department of Obstetrics and Gynecology, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel
    Fertil Steril 84:1779-82. 2005
    ..study was to investigate the immunocytochemical expression and presence of messenger RNA (mRNA) transcripts for leptin and its receptors in ovaries from human adults and adolescents and second- and third-trimester fetuses...
  96. ncbi A functional polymorphism in the promoter region of leptin gene increases susceptibility for non-small cell lung cancer
    Ricardo Ribeiro
    Molecular Oncology CI, Portuguese Institute of Oncology, Porto, Portugal
    Eur J Cancer 42:1188-93. 2006
    b>Leptin hormone and receptor have been associated to cancer development and were identified in lung tissue...
  97. ncbi Leptin modulates nitric oxide production and lipid metabolism in human placenta
    Veronica White
    Laboratory of Reproduction and Metabolism, CEFYBO CONICET, School of Medicine, University of Buenos Aires, Paraguay, Buenos Aires, Argentina
    Reprod Fertil Dev 18:425-32. 2006
    b>Leptin has significant effects on appetite, energy expenditure, lipid mobilisation and reproduction...
  98. ncbi Leptin, triglycerides, and interleukin 6 are independently associated with C-reactive protein in Japanese type 2 diabetic patients
    Takiko Yanagawa
    Division of Diabetes and Clinical Nutrition, Kansai Denryoku Hospital, Osaka Japan
    Diabetes Res Clin Pract 75:2-6. 2007
    ..glucose, and serum lipids (triglycerides, HDL cholesterol, and total cholesterol), interleukin 6 (IL-6), and leptin were measured...
  99. ncbi Lack of association between the tetranucleotide repeat polymorphism in the 3'-flanking region of the leptin gene and hypertension in severely obese patients
    S Maestrini
    Molecular Biology Laboratory, Ospedale San Giuseppe, Istituto Auxologico Italiano, Verbania, Italy
    J Endocrinol Invest 29:776-80. 2006
    Conflicting data suggest an association between leptin gene polymorphisms and essential hypertension independently of obesity...
  100. ncbi Sex differences in the association between leptin and CRP: results from the Dallas Heart Study
    Shuaib M Abdullah
    Donald W Reynolds Cardiovascular Clinical Research Center at the University of Texas Southwestern Medical Center, Dallas, TX 75390 9047, USA
    Atherosclerosis 195:404-10. 2007
    Higher C-reactive protein (CRP) levels in women compared with men may reflect sex differences in the relationship between obesity and inflammation. We evaluated how the adipokine leptin influenced these relationships.
  101. pmc leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3
    Neeraj K Saxena
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 282:13316-25. 2007
    ..b>Leptin, the key player in the regulation of energy balance and body weight control also acts as a growth factor on ..

Research Grants63

  1. Obese diabetic (type II) mouse model without leptin/leptin-receptor defects
    Richard G Peterson; Fiscal Year: 2013
    ..available commercially that have obesity, metabolic syndrome and type 2 diabetes, have genetic defects in leptin-receptors, leptin or in other hypothalamic peptides...
  2. Medication Summary Guides for Vulnerable Populations with Rheumatoid Arthritis
    Edward H Yelin; Fiscal Year: 2010
    ....
  3. Leah S Karliner; Fiscal Year: 2014
    ..If effective, the bedside interpreter intervention will be a model for hospitals across the nation to reduce disparities in care for the growing population of older LEP patients. ..
  4. CLIFFORD JAMES ROSEN; Fiscal Year: 2015
    ..Taken together, we hypothesize that IGFBP-2, which is induced by IGF-I, stimulates MSCs and OBs through HBD1...
  5. Technologically Enhanced Community Health Worker (CHW) Delivery of Personalized D
    MARY ELLEN MICHELE HEISLER; Fiscal Year: 2010
    ....
  6. Using Real-time Speech Translation for Medication Therapy Management of Spanish S
    FARZAD EHSANI; Fiscal Year: 2013
    ....
  7. Insulin Resistance in Tissue Specific IKKB Transgenics
    Jongsoon Lee; Fiscal Year: 2004
    ..These experiments will validate IKKbeta as a major mediator of insulin resistance and as a useful target for the discovery of new drugs to treat type 2 diabetes and insulin resistance. ..
  8. Melissa A Kacena; Fiscal Year: 2015
    ..However, our histological evaluation of GATA-1 and NF-E2 deficient mice reveals higher numbers of osteoblasts (OBs) on trabecular surfaces...
  9. Subburaman Mohan; Fiscal Year: 2015
    ..expression of osterix (Osx), a master osteogenic transcription factor, during differentiation of osteoblasts (OBs)...
  10. Dean T Yamaguchi; Fiscal Year: 2016
    ..disrupted bone given the circumstances that mesenchymal stem cells (MSCs) can differentiate into osteoblasts (OBs) and that new blood supply can be re-established...
  11. Paul R Odgren; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Bone resorption by osteoclasts (OCs) exceeding formation by osteoblasts (OBs) is a biological problem with a central role in widespread and costly disorders, including osteoporosis, osteo- and ..
  12. Louis M Pelus; Fiscal Year: 2016
    ..role of megakaryocytes (MKs) produced by the hematopoietic system in stimulating bone formation by osteoblasts (OBs);findings in the Pelus laboratory that define important roles for the major eicosanoid prostaglandin E2 (PGE2) in ..
  13. MECHANISMS OF POLARIZED SECRETION BY BONE CELLS
    Steven L Teitelbaum; Fiscal Year: 2013
    ..by applicant): Maintenance of bone mass requires the integrated activity of osteoclasts (OCs) and osteoblasts (OBs)...
  14. DEFINITION OF MICROENVIRONMENT IN BREAST CANCER
    Mina Bissell; Fiscal Year: 2013
    ..abstract_text> ..
  15. ROLAND E BARON; Fiscal Year: 2014
    ..Zfp521 expression in cultured osteoblasts (OBs) increases with time, and is regulated by BMP-2 and PTH/PTHrP...
  16. Regulation of apoptosis in osteoblasts by Runx2 and NFkB
    Roman Eliseev; Fiscal Year: 2013
    ..growth and remodeling of bone tissue, bone cells differentiate from mesenchymal stem cells to early proliferating OBs to mature post-mitotic OBs of which 30 percent become either osteocytes or lining cells while 70 percent are ..
  17. Jau Yi Li; Fiscal Year: 2015
    ..PTH binds to the PTH/PTH-related protein (PTHrP) receptor (PPR or PTH-1R), which is expressed on osteoblasts (OBs), osteocytes and bone marrow (BM) stromal cells (SCs)...
  18. OVARIECTOMY UPREGULATES BONE TURNOVER THROUGH T CELL-STROMAL CROSSTALK
    Roberto Pacifici; Fiscal Year: 2012
    ..to support OC formation, increase SC production of osteoclastogenic cytokines, and promote SC differentiation into OBs through stimulation of CD40 signaling in SCs by T cell expressed CD40L...
  19. Health Literacy and Cancer Screening Disparities in Asian American Populations
    Tetine Sentell; Fiscal Year: 2013
    ..This study also provides key background for our future research to reduce cancer incidence, mortality, and health disparities among AA. 1 ..
  20. Wen Cheng Xiong; Fiscal Year: 2015
    ..protein, is expressed not only in the brain/neurons, but also in many non- neuronal cells, including osteoblasts (OBs), osteoclasts (OCs), and bone marrow macrophages (BMMs)...
  21. Jane B Lian; Fiscal Year: 2016
    ..epigenetic marking of the OC gene for tissue specific activation, and regulation of target gene expression in OBs. Its deletion from OB in vitro and in vivo is postulated to alter OB maturation and contribute to a mild bone ..
  22. Inhibition of osteoblast function in bone erosion in rheumatoid arthritis
    Ellen M Gravallese; Fiscal Year: 2013
    ..However, data from our laboratory demonstrate a defect in the maturation of bone-forming osteoblasts (OBs) at sites of articular bone loss (erosions), with an accompanying inhibition in the formation of mineralized bone ..
  23. Carol C Pilbeam; Fiscal Year: 2016
    ..PTH is a potent inducer of COX-2 and PGs in OBs. Although PTH is generally thought to be osteogenic or anabolic only when given intermittently, continuous exposure ..
  24. The Virtual Patient for Improving Quality of Care in Primary Healthcare
    Richard Mollica; Fiscal Year: 2012
    ..The VP as a HIT innovation can provide sustainable training and quality of care improvement for disadvantaged patients and their PHC providers. ..
  25. ROBERT NISSENSON; Fiscal Year: 2015
    ..osteoblast Gi signaling negatively regulates bone formation;and 3) determine the role of Gq signaling in mature OBs in regulating skeletal homeostasis...
  26. X Edward Guo; Fiscal Year: 2014
    ..a central scientific hypothesis that that dynamic deformational loading induces OCYs to send anabolic signals to OBs to promote bone formation through intraceluar calcium [Ca2+]i oscillations in osteocytic network, followed by ..
  27. Modulation of Human Immunity by Mycobacterium leprae
    CLAUDIA M A MANCA; Fiscal Year: 2013
    ..The results of our proposed studies will facilitate the development of improved pharmacologic and/or vaccine strategies that can contribute to leprosy control. ..
  28. Robert L Modlin; Fiscal Year: 2016
    ..abstract_text> ..
  29. A Patient-Initiated, Multilingual Request Conveyance System
    WILLIAM Z TAN; Fiscal Year: 2012
    ....
  30. Improving Problem-Solving Performance of Students with Mathematics Difficulties
    ASHA KIRON JITENDRA; Fiscal Year: 2010
    ....
  31. CDC 42 BIM AND THE OSTEOCLAST
    Steven L Teitelbaum; Fiscal Year: 2010
    ..Moreover, Bim is also expressed in osteoblasts (OBs), where it regulates their lifespan and function...
  32. Delphine J Lee; Fiscal Year: 2014
    ....
  33. SimulTel: Enabling Remote Simultaneous Medical Interpreting
    Jyotsna Changrani; Fiscal Year: 2010
    ..abstract_text> ..
  34. Depression Screening in Primary Care: Using HIT for Patients with Limited English
    Dara H Sorkin; Fiscal Year: 2013
    ....
  35. Collaborative IVR Platform for Multilingual Patient Outreach and Education
    WILLIAM Z TAN; Fiscal Year: 2011
    ....
  36. Advancing Patient Call Light Systems to Achieve Better Outcomes
    Amy Wilson-Stronks; Fiscal Year: 2013
    ....
  37. Improving Outcomes for Mechanically Ventilated Patients with the Digital EZ Board
    MARY E HAPP; Fiscal Year: 2013
    ..The commercial opportunity lies in becoming the standard of care by facilitating effective communication to improve the care and comfort of patients in critical care units. ..
  38. TDARS: Translated Document Assembly and Retrieval System (Phase II)
    CYNTHIA ROAT; Fiscal Year: 2011
    ..Both the Agency for Healthcare Research and Quality (AHRQ) and the Office of Minority Health (OMH) have indicated that creating such a repository is a national priority. ..
  39. Tetine L Sentell; Fiscal Year: 2014
    ..We will use this information to design and test a personalized, consumer-focused website with the goal of improving the use of public hospital quality reports for pregnant women across diverse racial/ethnic and linguistic groups. ..
  40. Extending Emergency Response Skills to Limited English Proficiency Communities
    Hendrika Meischke; Fiscal Year: 2011
    ....
  41. Computer-based Patient Provider Communication about CAM Use
    WILLIAM Z TAN; Fiscal Year: 2011
    ....
  42. PGE2 and PTH effects on osteoblasts
    KATHERINE ANNE BLACKWELL; Fiscal Year: 2010
    ..Daily injection with parathyroid hormone (PTH) increases bone mass. In osteoblasts (OBs), cells that form bone tissue, PTH increases the expression of cyclooxygenase-2 (COX-2), which synthesizes the ..
  43. Impact of Physician non-English Language Proficiency Level on Cancer Screening
    Lisa C Diamond; Fiscal Year: 2013
    ..Level one will assess the probability of completing cancer screening at the patient level, including the covariates listed above. Level 2 will account for clinician factors listed above and level 3 will include clinician work sites. ..
  44. A Gateway to Innovations in Language-Concordant Health Services
    WILLIAM Z TAN; Fiscal Year: 2010
    ..The LanguageMate System brings together a set of highly innovative language tools designed to substantially improve access to healthcare for LEP patients. ..
  45. LEO SERGIO MORALES; Fiscal Year: 2015
    ..abstract_text> ..
  46. Communicative Competency Training for Foreign-Born Paraprofessionals
    WILLIAM Z TAN; Fiscal Year: 2012
    ....
  47. GENE THERAPY, OBESITY AND HYPOTHALAMIC SIGNALING
    Satya Kalra; Fiscal Year: 2005
    ..of this proposal is (1) to examine whether viral vector mediated delivery of weight-reducing signals, such as leptin, is a viable therapy (gene therapy), alternative to the pharmacologic approach, to control body weight (BW) gain ..
  48. BEHAVIORAL INTERVENTION FOR CHILDREN WITH CANCER
    Lonnie Zeltzer; Fiscal Year: 1990
    ..Pain and anxiety will be assessed in children (5-10 years) using patient (pt.) and observer (obs.) ratings and a behavioral checklist during 2 bone marrow aspirations and/or 2 lumbar punctures prior to ..
  49. Na Channels in Afferents after Bladder Obstruction
    William Steers; Fiscal Year: 2006
    ..Obstructed (OBS) rats exhibit urinary frequency and detrusor overactivity temporally correlated to the development of afferent ..
  50. EXPERIMENTAL LEPROSY/VACCINE STUDIES IN MANGABEYS
    Bobby Gormus; Fiscal Year: 1991
    ..Pure lymphokines will be added back to cell fractions from mangabeys with LL in attempts to reconstitute normal responses to mitogens and to D-lep...
  51. Protective Effects of Stearic Acid on Gestational and Acquired Diabetes Mellitus
    Eric Smart; Fiscal Year: 2009
    ..This aim is critical because each double crossed mouse line will provide the definitive mechanistic data regarding the role of each protein in mediating the beneficial effects of stearic acid. ..
  52. Richard O White; Fiscal Year: 2015
    ....
  53. Predictors of Adult Leukemia
    Julie Ross; Fiscal Year: 2009
    ..to metabolize NSAIDs, detoxify environmental toxins (including pesiticides, cigarette smoke) and metabolize leptin contributes to risk...
  54. Knowledge Management System for Multilingual Health Content
    WILLIAM Z TAN; Fiscal Year: 2011
    ..Improved patient-provider communication can serve to mitigate such adverse health outcomes as extended length of stay, increased frequency of diagnostic tests, misdiagnosis, and general dissatisfaction with healthcare. ..
  55. Effective Care of Latinos with Diabetes and Limited English Proficiency
    Alicia Fernandez; Fiscal Year: 2013
    ..Our results will inform health systems and clinicians seeking to improve diabetes care for Latinos with LEP and will provide a framework for intervention studies to reduce disparities for this population. ..
  56. BIOCHEMICAL CHARACTERIZATION OF GBS HYALURONATE LYASE
    David Pritchard; Fiscal Year: 1999
    B streptococci (OBS) are presently the most frequent cause of serious, often fatal, bacterial infections of neonates in the United States and are also a common cause of peripartum maternal sepsis...
  57. Using Real-time Speech Translation for Medication Therapy Management of Spanish S
    FARZAD EHSANI; Fiscal Year: 2010
    ..and UCSF propose to evaluate the feasibility of using a real-time speech translation device to facilitate Medication Therapy Management (MTM) of Limited English Proficient (LEP) patients with diabetes who primarily speak Spanish. ..
  58. Modeling Human Exposure-Dose Relationships:1,3-Butadiene
    Thomas Smith; Fiscal Year: 2005
    ..system and tracer methods; (2) To collect real-time measurements of breath-by-breath alveolar concentrations (-700 obs.) and optimize a physiologically-based pharmacokinetic (PBPK) model for estimating of metabolism rates; (3) To ..
  59. Computer Support for Pharmacy-Based Smoking Cessation
    FREDERICK BOCK; Fiscal Year: 2007
    ..from smokers to assess the extent of pharmacist counseling for smoking with no intervention (observation only: OBS). Pharmacists will then be trained in providing smoking cessation counseling...
  60. ANALYSIS OF E COLI GTP-BINDING PROTEINS AND THEIR GENES
    PAUL MARCH; Fiscal Year: 1993
    ..In addition, mutational studies similar to those proposed above will be employed to elucidate amino acid residues required by Ribonuclease III to recognize and cleave double stranded RNA...
  61. Role of aTGF-beta Regulated Gene in human and mouse osteoblasts and skeleton
    Thomas Spelsberg; Fiscal Year: 2007
    ..During this laboratory's investigations of estrogen (E2) and TGFb actions on OBs, we discovered and characterized the novel TGFb Iducible Early Gene-1 (TIEG) as a member of the Kruppel family of ..
  62. Applied Linguistics and Limited English Proficiency in the Medical Setting
    CAROLINE VICKERS; Fiscal Year: 2009
    ..The work will aid in health promotion, disease prevention, self- management in health and illness;as well as directly address health disparities of LEP groups. ..
  63. Bone and the Hematopoietic System
    Russell Taichman; Fiscal Year: 2004
    ..Thus, an intimate physical association between bone cells (osteoblasts or OBs) and HSCs is established early in life...