LCN2

Summary

Gene Symbol: LCN2
Description: lipocalin 2
Alias: 24p3, MSFI, NGAL, p25, neutrophil gelatinase-associated lipocalin, 25 kDa alpha-2-microglobulin-related subunit of MMP-9, migration-stimulating factor inhibitor, oncogene 24p3, siderocalin LCN2
Species: human

Top Publications

  1. ncbi Neutrophil gelatinase-associated lipocalin (NGAL) is a predictor of poor prognosis in human primary breast cancer
    Maret Bauer
    Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, Clinical Sciences Center K4 812, Madison, WI 53792 8550, USA
    Breast Cancer Res Treat 108:389-97. 2008
  2. ncbi Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase
    L Kjeldsen
    Departments of Hematology, University Hospital, Rigshospitalet, Copenhagen, Denmark
    J Biol Chem 268:10425-32. 1993
  3. ncbi Identification of common transcriptional regulatory elements in interleukin-17 target genes
    Fang Shen
    Department of Oral Biology, School of Dental Medicine, University at Buffalo, State University of New York, Buffalo, New York 14214, USA
    J Biol Chem 281:24138-48. 2006
  4. pmc Urine NGAL predicts severity of acute kidney injury after cardiac surgery: a prospective study
    Michael Bennett
    Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati, OH 45229 3039, USA
    Clin J Am Soc Nephrol 3:665-73. 2008
  5. ncbi The matrix metalloproteinase-9/neutrophil gelatinase-associated lipocalin complex plays a role in breast tumor growth and is present in the urine of breast cancer patients
    Cecilia A Fernandez
    Vascular Biology Program and Department of Surgery, Children s Hospital Boston, MA, USA
    Clin Cancer Res 11:5390-5. 2005
  6. ncbi Ligand preference inferred from the structure of neutrophil gelatinase associated lipocalin
    D H Goetz
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Biochemistry 39:1935-41. 2000
  7. doi NGAL decreases E-cadherin-mediated cell-cell adhesion and increases cell motility and invasion through Rac1 in colon carcinoma cells
    Limei Hu
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Lab Invest 89:531-48. 2009
  8. ncbi Lipocalin-2/neutrophil gelatinase-B associated lipocalin is strongly induced in hearts of rats with autoimmune myocarditis and in human myocarditis
    Limin Ding
    Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Japan
    Circ J 74:523-30. 2010
  9. pmc NGAL expression is elevated in both colorectal adenoma-carcinoma sequence and cancer progression and enhances tumorigenesis in xenograft mouse models
    Yan Sun
    Department of Pathology and Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
    Clin Cancer Res 17:4331-40. 2011
  10. pmc The neutrophil gelatinase-associated lipocalin (NGAL), a NF-kappaB-regulated gene, is a survival factor for thyroid neoplastic cells
    Alessio Iannetti
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Federico II University of Naples, Via S Pansini 5, 80131 Naples, Italy
    Proc Natl Acad Sci U S A 105:14058-63. 2008

Research Grants

  1. Recombinant hepatic argininosuccinate synthase (rASS) for treatment of sepsis/end
    Stanislav I Svetlov; Fiscal Year: 2012
  2. PDE5i with Tadalafil Changes the Extent of Renal Damage (PITCH_ER)
    Ravi Thadhani; Fiscal Year: 2013
  3. Long-term Prognosis of Acute Kidney Injury in Cardiac Surgery
    Steven G Coca; Fiscal Year: 2012
  4. Sushrut S Waikar; Fiscal Year: 2015
  5. Peroxynitrite Decomposition Catalyst and Nitric Oxide Donor for Endotoxemia
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
  6. A Hybrid Katp Channel Opener to Prevent Radiocontrast-Induced Nephropathy
    Kanneganti Murthy; Fiscal Year: 2012
  7. Edward B Garon; Fiscal Year: 2015
  8. Sushrut S Waikar; Fiscal Year: 2016
  9. Urinary Biomarkers for Recovery After Acute Kidney Injury and Prognosis in Hospit
    ISAAC ELI HALL; Fiscal Year: 2010
  10. MARK EDWARD WESTERMAN; Fiscal Year: 2014

Detail Information

Publications218 found, 100 shown here

  1. ncbi Neutrophil gelatinase-associated lipocalin (NGAL) is a predictor of poor prognosis in human primary breast cancer
    Maret Bauer
    Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, Clinical Sciences Center K4 812, Madison, WI 53792 8550, USA
    Breast Cancer Res Treat 108:389-97. 2008
    Neutrophil gelatinase-associated lipocalin (NGAL) is a small, secreted glycoprotein with proposed functions in cell proliferation, survival and morphogenesis...
  2. ncbi Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase
    L Kjeldsen
    Departments of Hematology, University Hospital, Rigshospitalet, Copenhagen, Denmark
    J Biol Chem 268:10425-32. 1993
    ..degree of similarity with the deduced sequences of rat alpha 2-microglobulin-related protein and the mouse protein 24p3. It is thus a new member of the lipocalin family...
  3. ncbi Identification of common transcriptional regulatory elements in interleukin-17 target genes
    Fang Shen
    Department of Oral Biology, School of Dental Medicine, University at Buffalo, State University of New York, Buffalo, New York 14214, USA
    J Biol Chem 281:24138-48. 2006
    ..Our recent microarray studies identified an acute phase response gene, 24p3/lipocalin 2, as a novel IL-17-induced gene. Here we describe a detailed analysis of the 24p3 promoter...
  4. pmc Urine NGAL predicts severity of acute kidney injury after cardiac surgery: a prospective study
    Michael Bennett
    Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati, OH 45229 3039, USA
    Clin J Am Soc Nephrol 3:665-73. 2008
    The authors have previously shown that urine neutrophil gelatinase-associated lipocalin (NGAL), measured by a research ELISA, is an early predictive biomarker of acute kidney injury (AKI) after cardiopulmonary bypass (CPB)...
  5. ncbi The matrix metalloproteinase-9/neutrophil gelatinase-associated lipocalin complex plays a role in breast tumor growth and is present in the urine of breast cancer patients
    Cecilia A Fernandez
    Vascular Biology Program and Department of Surgery, Children s Hospital Boston, MA, USA
    Clin Cancer Res 11:5390-5. 2005
    Having previously shown that the binding of neutrophil gelatinase-associated lipocalin (NGAL) to matrix metalloproteinase-9 (MMP-9) protects this extracellular matrix remodeling enzyme from autodegradation, we hypothesized that the ..
  6. ncbi Ligand preference inferred from the structure of neutrophil gelatinase associated lipocalin
    D H Goetz
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Biochemistry 39:1935-41. 2000
    b>Neutrophil gelatinase associated lipocalin (NGAL), a constituent of neutrophil granules, is a member of the lipocalin family of binding proteins...
  7. doi NGAL decreases E-cadherin-mediated cell-cell adhesion and increases cell motility and invasion through Rac1 in colon carcinoma cells
    Limei Hu
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Lab Invest 89:531-48. 2009
    Expression of neutrophil gelatinase-associated lipocalin (NGAL)/lipocalin2, a recently recognized iron regulatory protein that binds to matrix metalloproteinase-9 (MMP9), is increased in a spectrum of cancers, including those of the ..
  8. ncbi Lipocalin-2/neutrophil gelatinase-B associated lipocalin is strongly induced in hearts of rats with autoimmune myocarditis and in human myocarditis
    Limin Ding
    Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Japan
    Circ J 74:523-30. 2010
    Lipocalin-2/neutrophil gelatinase-B associated lipocalin (Lcn2/NGAL) is involved in the transport of iron and seems to play an important role in inflammation...
  9. pmc NGAL expression is elevated in both colorectal adenoma-carcinoma sequence and cancer progression and enhances tumorigenesis in xenograft mouse models
    Yan Sun
    Department of Pathology and Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
    Clin Cancer Res 17:4331-40. 2011
    There is growing evidence implicating that neutrophil gelatinase-associated lipocalin (NGAL) plays a role in the development and progression of cancers...
  10. pmc The neutrophil gelatinase-associated lipocalin (NGAL), a NF-kappaB-regulated gene, is a survival factor for thyroid neoplastic cells
    Alessio Iannetti
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Federico II University of Naples, Via S Pansini 5, 80131 Naples, Italy
    Proc Natl Acad Sci U S A 105:14058-63. 2008
    ..Proteomic analysis revealed that the neutrophil gelatinase-associated lipocalin (NGAL), a protein involved in inflammatory and immune responses, is secreted by FRO cells whereas its expression is ..
  11. ncbi Studies of the release and turnover of a human neutrophil lipocalin
    L Axelsson
    Department of Surgical Pathophysiology, University of Lund, Malmo University Hospital, Sweden
    Scand J Clin Lab Invest 55:577-88. 1995
    ..from human neutrophil extracts and shown to be the newly discovered neutrophil gelatinase-associated lipocalin (NGAL), based on structural and immunochemical data...
  12. doi Neutrophil gelatinase-associated lipocalin: a new antioxidant that exerts its cytoprotective effect independent on Heme Oxygenase-1
    Mehryar Habibi Roudkenar
    Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
    Free Radic Res 45:810-9. 2011
    Neutrophil Gelatinase-Associated Lipocalin (NGAL/Lcn2), a member of the lipocalin family, has a variety of functions. There are extensive studies examining the expression of NGAL under harmful conditions...
  13. doi Serum neutrophil gelatinase-associated lipocalin and interleukin-18 as predictive biomarkers for delayed graft function after kidney transplantation
    Eun Young Lee
    Department of Laboratory Medicine, Yonsei University College of Medicine, 50 Yonsei ro, Seodaemungu, Seoul, Korea
    J Clin Lab Anal 26:295-301. 2012
    ..We investigated the usefulness of serum neutrophil gelatinase-associated lipocalin (NGAL) and interleukin-18 (IL-18) for the prediction of DGF after kidney transplantation.
  14. doi Diagnostic performance of urinary kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin for acute kidney injury in an obstructive nephropathy patient
    Wei Xue
    Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
    Nephrology (Carlton) 19:186-94. 2014
    We investigated the diagnostic performance of urinary kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) for acute kidney injury (AKI) in 90 obstructive nephropathy patients.
  15. pmc Plasma neutrophil gelatinase-associated lipocalin and acute postoperative kidney injury in adult cardiac surgical patients
    Tjorvi E Perry
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Anesth Analg 110:1541-7. 2010
    ..We hypothesized that increased plasma neutrophil gelatinase-associated lipocalin (NGAL) measured immediately after separating from cardiopulmonary bypass (CPB) would predict AKI after CABG surgery.
  16. pmc Urinary neutrophil gelatinase-associated lipocalin as a marker of acute kidney injury after orthotopic liver transplantation
    Gebhard Wagener
    Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Nephrol Dial Transplant 26:1717-23. 2011
    Urinary neutrophil gelatinase-associated lipocalin (NGAL) is a novel, sensitive and specific biomarker that is rapidly released after kidney injury. It predicts acute kidney injury (AKI) in multiple clinical scenarios...
  17. doi Serum neutrophil gelatinase-associated lipocalin correlates with kidney function in renal allograft recipients
    Jolanta Malyszko
    Department of Nephrology, Medical University, Bialystok, Poland
    Clin Transplant 23:681-6. 2009
    The value of neutrophil gelatinase-associated lipocalin (NGAL) as a novel marker for early detection of acute renal failure has been highlighted recently...
  18. ncbi Neutrophil gelatinase-associated lipocalin immunoexpression in renal tumors: correlation with histotype and histological grade
    Valeria Barresi
    Departments of Human Pathology, University of Messina, Messina, Italy
    Oncol Rep 24:305-10. 2010
    Neutrophil gelatinase-associated lipocalin (NGAL) is a 25 kDa protein with roles in iron trafficking as well as in carcinogenesis and progression of several human neoplasias...
  19. pmc Disease and gender-specific dysregulation of NGAL and MMP-9 in type 1 diabetes mellitus
    Kathryn M Thrailkill
    Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, 72202, USA
    Endocrine 37:336-43. 2010
    Neutrophil gelatinase-associated lipocalin (NGAL), a biomarker of renal injury, can bind matrix metalloproteinase-9 (MMP-9) and inhibit its degradation, thereby sustaining MMP-9 proteolytic activity...
  20. doi Neutrophil gelatinase-associated lipocalin reflects the severity of renal impairment in subjects affected by chronic kidney disease
    Davide Bolignano
    Department of Internal Medicine, University of Messina, Messina, Italy
    Kidney Blood Press Res 31:255-8. 2008
    Neutrophil gelatinase-associated lipocalin (NGAL) is a small 25-kDa protein released from kidney tubular cells after harmful stimuli...
  21. ncbi Presence of NGAL/MMP-9 complexes in human abdominal aortic aneurysms
    Maggie Folkesson
    Department of Vascular Surgery, Karolinska University Hospital, Sweden
    Thromb Haemost 98:427-33. 2007
    ..Here, we analysed whether the neutrophil gelatinase-associated lipocalin (NGAL) is expressed within the thrombus and the aneurysm wall...
  22. doi Induction of lipocalin-2 expression in acute and chronic experimental liver injury moderated by pro-inflammatory cytokines interleukin-1β through nuclear factor-κB activation
    Erawan Borkham-Kamphorst
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH Aachen University Hospital, Aachen, Germany
    Liver Int 31:656-65. 2011
    Lipocalin-2 (LCN2) belongs to the lipocalin superfamily, sharing a barrel-shaped tertiary structure with a hydrophobic pocket and an ability to bind lipophilic molecules...
  23. ncbi Neutrophil gelatinase-associated lipocalin is a marker for dysregulated keratinocyte differentiation in human skin
    Lotus Mallbris
    Department of Dermatology, Karolinska Hospital, Stockholm, Sweden
    Exp Dermatol 11:584-91. 2002
    Neutrophil gelatinase-associated lipocalin (NGAL) is a 25-kDa protein initially isolated from the specific granules of human neutrophils...
  24. doi Neutrophil gelatinase-associated lipocalin as an early biomarker of nephropathy in diabetic patients
    Davide Bolignano
    Department of Internal Medicine, University of Messina, Messina, Italy
    Kidney Blood Press Res 32:91-8. 2009
    ..Renal tubulointerstitium plays an important role in the development and progression of diabetic nephropathy...
  25. doi Implication of human nonmetastatic clone 23 Type 1 and its downstream gene lipocalin 2 in metastasis and patient's survival of cancer of uterine cervix
    Po Hui Wang
    Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung, Taiwan
    Int J Cancer 129:2380-9. 2011
    ..Cervical cancer patients with positive nm23-H1 and negative lipocalin 2 should be followed and treated intensely...
  26. doi Diagnostic value of neutrophil gelatinase-associated lipocalin (NGAL) immunoexpression in follicular-patterned lesions of the thyroid gland
    Valeria Barresi
    Department of Human Pathology, University of Messina, Messina, Italy
    Virchows Arch 460:319-25. 2012
    Neutrophil gelatinase-associated lipocalin (NGAL) is a protein which participates in iron trafficking and which is involved in cancerogenesis and cancer progression...
  27. pmc Association between peritransplant kidney injury biomarkers and 1-year allograft outcomes
    Isaac E Hall
    Program of Applied Translational Research, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    Clin J Am Soc Nephrol 7:1224-33. 2012
    ..73 m(2))...
  28. pmc Associations of urinary levels of kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) with kidney function decline in the Multi-Ethnic Study of Atherosclerosis (MESA)
    Carmen A Peralta
    San Francisco VA Medical Center, San Francisco, CA 94121, USA
    Am J Kidney Dis 60:904-11. 2012
    ..Whether elevations in levels of urinary biomarkers of tubular injury (urine neutrophil gelatinase-associated lipocalin [NGAL] and kidney injury molecule 1 [KIM-1]) are associated with future risk of kidney disease has not been investigated.
  29. doi The cancer marker neutrophil gelatinase-associated lipocalin is highly expressed in human endometrial hyperplasia
    Chi Jr Liao
    Institute of Biochemical Science, College of Life Science, National Taiwan University, Taipei 10617, Taiwan
    Mol Biol Rep 39:1029-36. 2012
    ..The Lcn-2 gene encodes neutrophil gelatinase-associated lipocalin (NGAL), which promotes cell proliferation and serves as a cancer marker in some cancers...
  30. pmc Parenteral iron formulations differentially affect MCP-1, HO-1, and NGAL gene expression and renal responses to injury
    Ali C M Johnson
    Department of Medicine, University of Washington, Fred Hutchinson Cancer Research Center, Seattle, USA
    Am J Physiol Renal Physiol 299:F426-35. 2010
    ..by MTT assay (HK-2 cells), %LDH release (PTS), or renal cortical neutrophil gelatinase-associated lipoprotein (NGAL) protein/mRNA levels...
  31. doi Neutrophil gelatinase-associated lipocalin: a new prognostic marker in stage I colorectal carcinoma?
    Valeria Barresi
    Department of Human Pathology, University of Messina, 98125 Messina, Italy
    Hum Pathol 42:1720-6. 2011
    ....
  32. doi Serum lipocalin-2 as an insulin resistance marker in patients with polycystic ovary syndrome
    E Cakal
    Department of Endocrinology, Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey
    J Endocrinol Invest 34:97-100. 2011
    ..Our aim was to investigate levels of lipocalin-2 and its relationship with metabolic factors in women with polycystic ovary syndrome (PCOS)...
  33. ncbi Ectopic expression of neutrophil gelatinase-associated lipocalin suppresses the invasion and liver metastasis of colon cancer cells
    Ho Jeong Lee
    New Biologics Team, Mogam Biotechnology Research Institute, Yongin City, Republic of Korea
    Int J Cancer 118:2490-7. 2006
    Neutrophil gelatinase-associated lipocalin (NGAL), also known as lipocalin 2, is a 25-kDa lipocalin initially purified from neutrophil granules...
  34. ncbi Neutrophil gelatinase-associated lipocalin is expressed in osteoarthritis and forms a complex with matrix metalloproteinase 9
    Kalpana Gupta
    Case Western Reserve University, and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    Arthritis Rheum 56:3326-35. 2007
    ..Among these bands is an approximately 125-130-kd band for high molecular weight (HMW) gelatinase, which has not been characterized. This study was undertaken to characterize the HMW MMP activity in OA SF...
  35. doi Serum neutrophil gelatinase-associated lipocalin as a marker of renal function in patients with chronic heart failure and coronary artery disease
    Boguslaw Poniatowski
    Department of Invasive Cardiology, and Hypertension, Medical University, Bialystok, Poland
    Kidney Blood Press Res 32:77-80. 2009
    ..The aim of the study was to assess whether neutrophil gelatinase-associated lipocalin (NGAL) could represent a novel, sensitive marker of kidney function in adult patients with chronic heart failure and ..
  36. doi NFAT3 transcription factor inhibits breast cancer cell motility by targeting the Lipocalin 2 gene
    M Fougere
    CNRS UMR7212, INSERM U944, Universite Paris Diderot, Institut d Hematologie, Hopital Saint Louis, Paris Cedex 10, France
    Oncogene 29:2292-301. 2010
    ..NFAT3 signaling reduces migration through inhibition of Lipocalin 2 (LCN2) gene expression...
  37. ncbi A 25 kDa alpha 2-microglobulin-related protein is a component of the 125 kDa form of human gelatinase
    S Triebel
    Department of Biochemistry, Faculty of Chemistry, University of Bielefeld, Germany
    FEBS Lett 314:386-8. 1992
    ..The amino acid sequence of tryptic peptides of this protein revealed homology with an alpha 2-microglobulin-related protein from rats, a protein so far unknown in humans...
  38. ncbi The solution structure and dynamics of human neutrophil gelatinase-associated lipocalin
    M Coles
    Institut fur Organische Chemie und Biochemie, Technische Universitat Munchen, Lichtenbergstrasse 4, Garching, 85747, Germany
    J Mol Biol 289:139-57. 1999
    ....
  39. ncbi A sandwich enzyme immunoassay for the determination of neutrophil lipocalin in body fluids
    J Blaser
    Faculty of Chemistry, Department of Biochemistry, University of Bielefeld, Germany
    Clin Chim Acta 235:137-45. 1995
    ..1 micrograms/l; n = 9). Very high concentrations of this lipocalin were found in the synovial fluids of patients suffering from inflammatory rheumatoid arthritis (1.7 +/- 1.4 mg/l; n = 37)...
  40. ncbi Molecular characterization and pattern of tissue expression of the gene for neutrophil gelatinase-associated lipocalin from humans
    J B Cowland
    Granulocyte Research Laboratory, Finsen Center, Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Denmark
    Genomics 45:17-23. 1997
    Neutrophil gelatinase-associated lipocalin (NGAL) is a 25-kDa lipocalin first identified as a protein stored in specific granules of the human neutrophil...
  41. ncbi Heterogeneous expression of the lipocalin NGAL in primary breast cancers
    S P Stoesz
    Department of Human Oncology, University of Wisconsin, Madison 53792, USA
    Int J Cancer 79:565-72. 1998
    ..Here, we characterize the putative human homolog of NRL, neutrophil gelatinase-associated lipocalin (NGAL). ngal gene expression was found at moderate levels in only 2 of 17 human tissues examined, breast and lung...
  42. ncbi Urine NGAL and IL-18 are predictive biomarkers for delayed graft function following kidney transplantation
    C R Parikh
    Nephrology, Yale University, New Haven, Connecticut, USA
    Am J Transplant 6:1639-45. 2006
    ..We tested whether urinary neutrophil gelatinase-associated lipocalin (NGAL) and interleukin-18 (IL-18) represent early biomarkers for DGF (defined as dialysis requirement within the first ..
  43. ncbi Urinary neutrophil gelatinase-associated lipocalin (NGAL) is an early biomarker for renal tubulointerstitial injury in IgA nephropathy
    Hanlu Ding
    Department of Nephrology, Daping Hospital, The Third Military Medical University, Chongqing 40038, PR China
    Clin Immunol 123:227-34. 2007
    ..Neutrophil gelatinase-associated lipocalin (NGAL) is an acute phase protein that is rapidly released from not only neutrophils but also a variety of cell types upon ..
  44. ncbi Urinary lipocalin-2 is associated with renal disease activity in human lupus nephritis
    Milena Pitashny
    Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Arthritis Rheum 56:1894-903. 2007
    ....
  45. ncbi Lipocalin 2-mediated growth suppression is evident in human erythroid and monocyte/macrophage lineage cells
    Kenichi Miharada
    Cell Engineering Division, RIKEN BioResource Center, Tsukuba, Ibaraki, Japan
    J Cell Physiol 215:526-37. 2008
    Lipocalin 2 (LCN2), a secreted protein of the lipocalin family, induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore...
  46. doi Serum concentrations of atherogenic proteins neutrophil gelatinase-associated lipocalin and its complex with matrix metalloproteinase-9 are significantly lower in women with polycystic ovary syndrome: hint of a protective mechanism?
    Evanthia Diamanti-Kandarakis
    Endocrine Section, First Department of Medicine, Medical School, Laiko General Hospital, University of Athens, 11527 Athens, Greece
    Eur J Endocrinol 158:525-31. 2008
    Neutrophil gelatinase-associated lipocalin (NGAL) and matrix metalloproteinase-9 (MMP-9) have been considered as important mediators of vascular remodeling and plaque instability...
  47. pmc Lipocalin 2 is required for BCR-ABL-induced tumorigenesis
    X Leng
    Department of Molecular Pathology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Oncogene 27:6110-9. 2008
    Our previous studies indicate that reduction of lipocalin 2 (mouse 24p3) expression by either anti-sense or siRNA approaches strongly reduces the overgrowth of BCR-ABL+ mouse myeloid 32D in marrow and spleen of NOD/SCID mice...
  48. pmc Neutrophil gelatinase-associated lipocalin: a novel suppressor of invasion and angiogenesis in pancreatic cancer
    Zhimin Tong
    Department of Gastroenterology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 68:6100-8. 2008
    Neutrophil gelatinase-associated lipocalin (NGAL) is a 25-kDa secreted acute phase protein, which is also up-regulated in multiple cancers, including breast, lung, and pancreas...
  49. doi Expression of neutrophil gelatinase-associated lipocalin in nasal polyps
    Hyun Jae Woo
    Department of Otorhinolaryngology Head and Neck Surgery, College of Medicine, Yeungnam University, Daegu, South Korea
    Arch Otolaryngol Head Neck Surg 134:1182-6. 2008
    To investigate the expression and localization of neutrophil gelatinase-associated lipocalin (NGAL), an antimicrobial peptide, in the normal nasal mucosa and human nasal polyps...
  50. doi Urinary neutrophil gelatinase-associated lipocalin levels reflect damage to glomeruli, proximal tubules, and distal nephrons
    Takashige Kuwabara
    Department of Medicine and Clinical Science, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan
    Kidney Int 75:285-94. 2009
    Urinary neutrophil gelatinase-associated lipocalin (Ngal or lipocalin 2) is a very early and sensitive biomarker of kidney injury...
  51. doi Roles of neutrophil gelatinase-associated lipocalin in continuous ambulatory peritoneal dialysis-related peritonitis
    Joseph C K Leung
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Room 409, Professorial Block, 102 Pokfulam Road, Hong Kong, China
    J Clin Immunol 29:365-78. 2009
    We measured the neutrophil gelatinase-associated lipocalin (NGAL) concentration in peritoneal dialysate effluent (PDE) collected following an acute episode of continuous ambulatory peritoneal dialysis (CAPD)-related peritonitis.
  52. doi Early prediction of urinary tract infection with urinary neutrophil gelatinase associated lipocalin
    Alev Yilmaz
    Pediatric Nephrology, Bakirkoy Maternity and Childrens Hospital, Bogazkoy Kardelen Villalari No 26 Bahcesehir, Istanbul, Turkey
    Pediatr Nephrol 24:2387-92. 2009
    b>Neutrophil gelatinase associated lipocalin (NGAL) is a protein identified in human neutrophil granules...
  53. doi Accuracy of neutrophil gelatinase-associated lipocalin (NGAL) in diagnosis and prognosis in acute kidney injury: a systematic review and meta-analysis
    Michael Haase
    Department of Nephrology and Intensive Care Medicine, Charite University Medicine, Berlin, Germany
    Am J Kidney Dis 54:1012-24. 2009
    Neutrophil gelatinase-associated lipocalin (NGAL) appears to be a promising biomarker for the early diagnosis of acute kidney injury (AKI); however, a wide range in its predictive value has been reported.
  54. pmc Upregulation of neutrophil gelatinase-associated lipocalin by ErbB2 through nuclear factor-kappaB activation
    Shau Hsuan Li
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer Res 69:9163-8. 2009
    ..Neutrophil gelatinase-associated lipocalin (NGAL) is a secreted glycoprotein expressed in a variety of cancers, including breast carcinomas...
  55. doi Neutrophil gelatinase-associated lipocalin in dialyzed patients is related to residual renal function, type of renal replacement therapy and inflammation
    Jolanta Malyszko
    Department of Nephrology, Medical University, Bialystok, Poland
    Kidney Blood Press Res 32:464-9. 2009
    Neutrophil gelatinase-associated lipocalin (NGAL) has recently been proved useful in the quantitation of chronic kidney disease...
  56. pmc Neutrophil gelatinase-associated lipocalin expresses antimicrobial activity by interfering with L-norepinephrine-mediated bacterial iron acquisition
    Marcus Miethke
    Munich Center for Integrated Protein Science, CIPS M, Lehrstuhl fur Biologische Chemie, Technische Universitat Munchen, 85350 Freising Weihenstephan, Germany
    Antimicrob Agents Chemother 54:1580-9. 2010
    ..NE resemble those of bacterial siderophores that are scavenged by human neutrophil gelatinase-associated lipocalin (NGAL) as part of the innate immune defense...
  57. pmc Serum neutrophil gelatinase-associated lipocalin (NGAL) in predicting worsening renal function in acute decompensated heart failure
    Arash Aghel
    Education Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Card Fail 16:49-54. 2010
    ..Neutrophil gelatinase-associated lipocalin (NGAL) is produced by the nephron in response to tubular epithelial damage and serves as an early marker for acute renal ..
  58. ncbi Serum neutrophil gelatinase-associated lipocalin in patients with colorectal liver metastases: preliminary results of an exploratory prospective study
    Josep Martí
    Liver Surgery and Transplantation Unit, Institut Clínic de Malalties Digestives i Metabolisme, IDIBAPS, Hospital Clinic i Provincial, CIBERehd, University of Barcelona, Barcelona Spain
    Int J Biol Markers 25:21-6. 2010
    To quantify preoperative serum neutrophil gelatinase-associated lipocalin (NGAL) levels in patients undergoing curative resection of colorectal liver metastases and to assess the relationship between NGAL levels and prognostic features in ..
  59. pmc Neutrophil gelatinase-associated lipocalin in the diagnosis of type 1 cardio-renal syndrome in the general ward
    Margarida Alvelos
    Department of Internal Medicine, Hospital Sao Joao, Porto, Portugal
    Clin J Am Soc Nephrol 6:476-81. 2011
    ..This study aimed to assess the performance of neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C in the early detection of type 1 cardio-renal syndrome in patients with acute HF.
  60. pmc Glomerular and tubular damage markers are elevated in patients with diabetes
    Ferdau L Nauta
    Department of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Diabetes Care 34:975-81. 2011
    ..kidney injury molecule [KIM]-1, N-acetyl-β-d-glucosaminidase [NAG], neutrophil gelatinase-associated lipocalin [NGAL], and cystatin C), and distal tubular (heart fatty acid-binding protein [H-FABP]) damage markers with kidney ..
  61. doi Significant elevation and correlation of plasma neutrophil gelatinase associated lipocalin and its complex with matrix metalloproteinase-9 in patients with pelvic inflammatory disease
    Hsiu Ting Tsai
    School of Nursing, Chung Shan Medical University, Taiwan
    Clin Chim Acta 412:1252-6. 2011
    To detect the expression of plasma neutrophil gelatinase associated lipocalin (NGAL) and its complex with matrix metalloproteinase-9 (MMP-9) in patients with pelvic inflammatory disease (PID).
  62. doi Neutrophil gelatinase-associated lipocalin (NGAL) and matrix metalloproteinase-9 (MMP-9) prognostic value in stage I colorectal carcinoma
    Valeria Barresi
    Department of Human Pathology, University of Messina, Italy
    Pathol Res Pract 207:479-86. 2011
    The expression of neutrophil gelatinase-associated lipocalin (NGAL) has been suggested to behave like a negative prognostic marker in stage I colorectal carcinoma...
  63. doi Urine neutrophil gelatinase-associated lipocalin (uNGAL) and netrin-1: are they effectively improving the clinical management of sepsis-induced acute kidney injury (AKI)?
    Michele Mussap
    Department of Laboratory Medicine, University Hospital San Martino, Genova, Italy
    J Matern Fetal Neonatal Med 24:15-7. 2011
    Neutrophil gelatinase-associated lipocalin (NGAL) and Netrin-1 have been proposed over the past years as emergent biomarkers for the early and accurate diagnosis and monitoring of acute kidney injury (AKI)...
  64. doi Immunohistochemical detection of a specific receptor for lipocalin2 (solute carrier family 22 member 17, SLC22A17) and its prognostic significance in endometrial carcinoma
    Tsutomu Miyamoto
    Department of Obstetrics and Gynecology, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Exp Mol Pathol 91:563-8. 2011
    We previously reported the overexpression of lipocalin2 (LCN2), a 25kDa secretory protein involved in iron-transportation, in endometrial carcinoma and its possible contribution to endometrial carcinogenesis...
  65. doi Role of genetic variants in the gene encoding lipocalin-2 in the development of elevated blood pressure
    Kwok Leung Ong
    Department of Medicine, University of Hong Kong
    Clin Exp Hypertens 33:484-91. 2011
    ..investigated the association of common single nucleotide polymorphisms (SNPs) in the gene encoding lipocalin-2 (LCN2) with elevated blood pressure (BP) in Hong Kong Chinese...
  66. pmc Lipocalin-2, glucose metabolism and chronic low-grade systemic inflammation in Chinese people
    Ying Huang
    Institute of Endocrinology and Diabetology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
    Cardiovasc Diabetol 11:11. 2012
    ..Lipocalin-2 is a novel adipokine with connection to insulin resistance. In this study, we aimed to investigate the association of serum lipocalin-2 with glucose metabolism and other metabolic phenotype in a large-scale Chinese population...
  67. doi Neutrophil gelatinase-associated lipocalin as an early biomarker of acute kidney injury in liver transplantation
    Tae Dong Jeong
    Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea
    Clin Transplant 26:775-81. 2012
    ..We evaluated the utility of urine and plasma neutrophil gelatinase-associated lipocalin (NGAL) concentrations as biomarkers of AKI during and after liver transplantation.
  68. pmc Lipocalin 2 expression is associated with aggressive features of endometrial cancer
    Monica Mannelqvist
    The Gade Institute, Section for Pathology, University of Bergen, Bergen, Norway
    BMC Cancer 12:169. 2012
    Increased expression of lipocalin 2 (LCN2) has been observed in several cancers...
  69. pmc Interleukin-10-induced neutrophil gelatinase-associated lipocalin production in macrophages with consequences for tumor growth
    Michaela Jung
    Institute of Biochemistry I, Goethe University Frankfurt, Frankfurt am Main, Germany
    Mol Cell Biol 32:3938-48. 2012
    ..Here we explored molecular mechanisms allowing IL-10 to upregulate the protumorigenic protein NGAL in primary human macrophages...
  70. pmc Neutrophil gelatinase-associated lipocalin (NGAL) predicts response to neoadjuvant chemotherapy and clinical outcome in primary human breast cancer
    Antonia Sophie Wenners
    Department of Gynecology and Obstetrics, University Medical Center Schleswig Holstein, Kiel, Germany
    PLoS ONE 7:e45826. 2012
    In our previous work we showed that NGAL, a protein involved in the regulation of proliferation and differentiation, is overexpressed in human breast cancer (BC) and predicts poor prognosis...
  71. pmc Effects of ectopic expression of NGAL on doxorubicin sensitivity
    William H Chappell
    Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA
    Oncotarget 3:1236-45. 2012
    Neutrophil gelatinase-associated lipocalin (NGAL, a.k...
  72. pmc Expression of neutrophil gelatinase-associated lipocalin in colorectal neoplastic progression: a marker of malignant potential?
    M H McLean
    Gastrointestinal Research Group, Division of Applied Medicine, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Br J Cancer 108:2537-41. 2013
    Neutrophil gelatinase-associated lipocalin (NGAL) has a diverse functional repertoire, involved in the innate immune response as well as cell growth and differentiation...
  73. doi Estimation of tissue and serum lipocalin-2 in psoriasis vulgaris and its relation to metabolic syndrome
    H el-Hadidi
    Department of Dermatology, Faculty of Medicine, Cairo University, Giza, Egypt
    Arch Dermatol Res 306:239-45. 2014
    ..Lipocalin-2 has no role in determining severity of the disease. Neither tissue nor serum lipocalin-2 conveys cardiovascular risk in psoriasis patients. ..
  74. pmc Predictive performance of urine neutrophil gelatinase-associated lipocalin for dialysis requirement and death following cardiac surgery in neonates and infants
    Mirela Bojan
    Department of Anesthesiology and Critical Care and, Department of Biochemistry, Necker Enfants Malades Hospital, Assistance Publique Hopitaux de Paris, France, Unite de recherche clinique, CIC Centre Necker Cochin, Assistance Publique Hopitaux de Paris, France, Institut National de la Sante et de la Recherche Medicale, Paris Sud University and Paris Descartes University, Paris, France, Paul Brousse Hospital, Assistance Publique, Hopitaux de Paris, France, Paris Descartes University, Paris, France, Department of Anesthesiology and Critical Care, Georges Pompidou European Hospital, Assistance Publique Hopitaux de Paris, France
    Clin J Am Soc Nephrol 9:285-94. 2014
    ..The present study explores the accuracy of uNGAL for the prediction of severe AKI-related outcomes in neonates and infants undergoing cardiac surgery: dialysis requirement and/or death within 30 days...
  75. ncbi Molecular cloning and expression of a cDNA encoding NGAL: a lipocalin expressed in human neutrophils
    J R Bundgaard
    Department of Clinical Biochemistry, Rigshospitalet, University Hospital, Copenhagen, Denmark
    Biochem Biophys Res Commun 202:1468-75. 1994
    b>NGAL, a protein recently isolated from human neutrophils, is a novel member of the lipocalins...
  76. ncbi Neutrophil gelatinase-associated lipocalin in normal and neoplastic human tissues. Cell type-specific pattern of expression
    A Friedl
    Department of Pathology and Laboratory Medicine, Madison, WI 53792, USA
    Histochem J 31:433-41. 1999
    Neutrophil gelatinase-associated lipocalin (NGAL) has recently been identified in myeloperoxidase-negative neutrophil granules...
  77. ncbi Expression of NRL/NGAL (neu-related lipocalin/neutrophil gelatinase-associated lipocalin) during mammalian embryonic development and in inflammation
    B Zerega
    Istituto Nazionale per la Ricerca sul Cancro, Centro di Biotecnologie Avanzate, Genova Italy
    Eur J Cell Biol 79:165-72. 2000
    ..is SIP24, an acute phase protein induced in the animal by turpentine injection; the human homologous protein is NGAL expressed in granulocytes and epithelial cells in pathological conditions, such as inflammation and malignancy...
  78. ncbi Induction of apoptosis by a secreted lipocalin that is transcriptionally regulated by IL-3 deprivation
    L R Devireddy
    Howard Hughes Medical Institute, Program in Gene Function and Expression and Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
    Science 293:829-34. 2001
    ..12 pro-B cells, we found that the gene undergoing maximal transcriptional induction after cytokine withdrawal is 24p3, which encodes a secreted lipocalin. Conditioned medium from IL-3-deprived FL5...
  79. ncbi Expression of neutrophil gelatinase-associated lipocalin regulates epithelial morphogenesis in vitro
    Jane A Gwira
    Department of Medicine, Yale University, New Haven, Connecticut 06520, USA
    J Biol Chem 280:7875-82. 2005
    ..study, we demonstrate that HGF stimulates epithelial cells to express neutrophil gelatinase-associated lipocalin (Ngal), a member of the lipocalin family of secreted proteins that has recently been shown to participate in mesenchymal-..
  80. ncbi The endocytic receptor megalin binds the iron transporting neutrophil-gelatinase-associated lipocalin with high affinity and mediates its cellular uptake
    Vibeke Hvidberg
    Institute of Medical Biochemistry, University of Aarhus, Denmark
    FEBS Lett 579:773-7. 2005
    Neutrophil-gelatinase-associated lipocalin (NGAL) is a prominent protein of specific granules of human neutrophils also synthesized by epithelial cells during inflammation...
  81. ncbi Lipocalin 2 diminishes invasiveness and metastasis of Ras-transformed cells
    Jun Ichi Hanai
    Division of Nephrology, Department of Medicine and Center for Study of the Tumor Microenvironment, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 280:13641-7. 2005
    ..Lipocalin 2 action was enhanced by iron-siderophore. These data characterize lipocalin 2 as an epithelial inducer in Ras malignancy and a suppressor of metastasis...
  82. pmc Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury
    Kiyoshi Mori
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    J Clin Invest 115:610-21. 2005
    Neutrophil gelatinase-associated lipocalin (Ngal), also known as siderocalin, forms a complex with iron-binding siderophores (Ngal:siderophore:Fe). This complex converts renal progenitors into epithelial tubules...
  83. pmc Neutrophil gelatinase-associated lipocalin as a survival factor
    Zhimin Tong
    Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, TX, USA
    Biochem J 391:441-8. 2005
    NGAL (human neutrophil gelatinase-associated lipocalin) and its mouse analogue 24p3 are members of the lipocalin family of small secreted proteins...
  84. ncbi Expression of neutrophil gelatinase-associated lipocalin in atherosclerosis and myocardial infarction
    Anne Louise Hemdahl
    Center for Molecular Medicine, Department of Medicine, Karolinska Hospital, Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 26:136-42. 2006
    Neutrophil gelatinase-associated lipocalin (NGAL) modulates the activity of matrix metalloproteinase (MMP) 9, an important mediator of vascular remodeling and plaque instability in atherosclerosis...
  85. ncbi Expression of neutrophil gelatinase-associated lipocalin in skin epidermis
    Seong Jun Seo
    J Invest Dermatol 126:510-2. 2006
  86. ncbi Regulation of lipocalin-2 gene by the cancer chemopreventive retinoid 4-HPR
    Stefano Caramuta
    Department of Experimental Oncology, Istituto Nazionale Tumori, Milan, Italy
    Int J Cancer 119:1599-606. 2006
    ..profile of human breast cancer cell lines, MCF7 and T47D, treated with 4-HPR, we identified the lipocalin member LCN2 (NGAL or 24p3) as a gene, markedly induced by the retinoid...
  87. pmc Identification of biomarkers of human pancreatic adenocarcinomas by expression profiling and validation with gene expression analysis in endoscopic ultrasound-guided fine needle aspiration samples
    Henrik Laurell
    INSERM U531, IFR31, Institut Louis Bugnard, Toulouse, France
    World J Gastroenterol 12:3344-51. 2006
    ....
  88. ncbi Lipocalin 2 antagonizes the proangiogenic action of ras in transformed cells
    Shivalingappa Venkatesha
    Renal Division and Center for Study of the Tumor Microenvironment, Department of Medicine, Beth Israel Deaconess Medical, 330 Brookline Avenue, RW 563, Boston, MA 02215, USA
    Mol Cancer Res 4:821-9. 2006
    ....
  89. ncbi Dual action of neutrophil gelatinase-associated lipocalin
    Kai M Schmidt-Ott
    Department of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    J Am Soc Nephrol 18:407-13. 2007
    Neutrophil gelatinase-associated lipocalin (NGAL) is expressed and secreted by immune cells, hepatocytes, and renal tubular cells in various pathologic states...
  90. pmc A novel alternative spliced variant of neutrophil gelatinase-associated lipocalin receptor in oesophageal carcinoma cells
    Wang Kai Fang
    Department of Biochemistry and Molecular Biology, Medical College of Shantou University, Shantou 515041, Guangdong Province, China
    Biochem J 403:297-303. 2007
    Recent studies suggest that NGAL (neutrophil gelatinase-associated lipocalin) is a novel iron transporter with functions distinct from that of transferrin and mediates a new iron-delivery pathway...
  91. ncbi Neutrophil gelatinase-associated lipocalin (NGAL) an early-screening biomarker for ovarian cancer: NGAL is associated with epidermal growth factor-induced epithelio-mesenchymal transition
    Ratana Lim
    Gynaecological Cancer Research Centre, Royal Women s Hospital, Carlton, Victoria, Australia
    Int J Cancer 120:2426-34. 2007
    The expression of neutrophil gelatinase-associated lipocalin (NGAL) has been shown to be upregulated in ovarian cancer cells...
  92. ncbi Neutrophil gelatinase-associated lipocalin in patients with autosomal-dominant polycystic kidney disease
    Davide Bolignano
    Department of Internal Medicine, University of Messina, Messina, Italy
    Am J Nephrol 27:373-8. 2007
    ..Neutrophil gelatinase-associated lipocalin (NGAL) is a protein expressed on tubular cells of which the production is markedly increased in response to harmful ..
  93. ncbi NGAL is an early predictive biomarker of contrast-induced nephropathy in children
    Russel Hirsch
    Division of Cardiology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Pediatr Nephrol 22:2089-95. 2007
    We hypothesized that neutrophil gelatinase-associated lipocalin (NGAL) is an early predictive biomarker of contrast-induced nephropathy (CIN)...
  94. pmc Plasma neutrophil gelatinase-associated lipocalin predicts acute kidney injury, morbidity and mortality after pediatric cardiac surgery: a prospective uncontrolled cohort study
    Catherine L Dent
    Department of Cardiology, Cincinnati Children s Hospital Medical Center, University of Cincinnati School of Medicine, 3333 Burnet Ave, Cincinnati, Ohio 45229, USA
    Crit Care 11:R127. 2007
    ..We previously showed in a small cohort of patients that plasma neutrophil gelatinase-associated lipocalin (NGAL), measured using a research enzyme-linked immunosorbent assay, is an early predictive biomarker of AKI after CPB...
  95. doi Urinary IL-18 and NGAL as early predictive biomarkers in contrast-induced nephropathy after coronary angiography
    Wang Ling
    Renal Division, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Nephron Clin Pract 108:c176-81. 2008
    ..designed to investigate whether human urinary interleukin-18 (IL-18) and neutrophil gelatinase-associated lipocalin (NGAL) are early predictive markers for AKI after coronary angiography and their correlation with later cardiac events.
  96. pmc Early diagnosis of pancreatic cancer: neutrophil gelatinase-associated lipocalin as a marker of pancreatic intraepithelial neoplasia
    N Moniaux
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Br J Cancer 98:1540-7. 2008
    ..Neutrophil gelatinase-associated lipocalin (NGAL), a 24-kDa glycoprotein, was reported to be upregulated nearly 27-fold in pancreatic cancer cells compared to ..
  97. doi Lipocalin-2: development, analytical characterization, and clinical testing of a new ELISA
    D Stejskal
    Department of Laboratory Medicine and Department of Medicine, Sternberk Hospital, Sternberk, Czech Republic
    Horm Metab Res 40:381-5. 2008
    Lipocalin-2 (also known as neutrophil gelatinase-associated lipocalin [NGAL]) has been described as a promising marker of metabolic syndrome associated with inflammation...
  98. pmc Expression of neutrophil gelatinase-associated lipocalin in calcium-induced keratinocyte differentiation
    Jeung Hoon Lee
    Department of Dermatology, School of Medicine, Chungnam National University, 640 Daesa dong, Jung Gu, Daejeon, Korea
    J Korean Med Sci 23:302-6. 2008
    ..expressed genes in keratinocyte differentiation, we identified neutrophil gelatinase-associated lipocalin (NGAL) as a calcium-induced gene...
  99. doi Neutrophil gelatinase-associated lipocalin expression in chronic myeloid leukemia
    Claire Villalva
    Service d Hématologie et Oncologie Biologique EA 3805, CHU de Poitiers, Universite de Poitiers, France
    Leuk Lymphoma 49:984-8. 2008
    The murine equivalent of neutrophil gelatinase-associated lipocalin (NGAL) was previously found to be increased by BCR-ABL expression in murine models of chronic myeloid leukemia (CML)...
  100. doi Effect of exercise training on A-FABP, lipocalin-2 and RBP4 levels in obese women
    K M Choi
    Department of Internal Medicine, Division of Endocrinology and Metabolism, College of Medicine, Korea University, Seoul, Korea
    Clin Endocrinol (Oxf) 70:569-74. 2009
    ..We have evaluated the effect of exercise training on lipocalin family proteins and inflammatory markers...

Research Grants84

  1. Recombinant hepatic argininosuccinate synthase (rASS) for treatment of sepsis/end
    Stanislav I Svetlov; Fiscal Year: 2012
    ..Others, including ALT, NGAL, and troponin are indicative of more specific organ damage such as liver, kidney, and heart, respectively...
  2. PDE5i with Tadalafil Changes the Extent of Renal Damage (PITCH_ER)
    Ravi Thadhani; Fiscal Year: 2013
    ..The PITCH-HF Executive Committee and the NHLBI reviewers agree this proposal may radically shift the clinical care paradigm for patients with CKD, AKI, and CHF. ..
  3. Long-term Prognosis of Acute Kidney Injury in Cardiac Surgery
    Steven G Coca; Fiscal Year: 2012
    ..In addition, we will examine if newly discovered biomarkers of acute kidney injury (urinary IL-18 and NGAL) are associated with CKD and death...
  4. Sushrut S Waikar; Fiscal Year: 2015
    ..hospitals in Boston, Massachusetts and measure urinary and tissue levels of novel biomarkers, including KIM-1, NAG, NGAL, MCP-1, L-FABP, IL-18, HGF, VEGF, IP-10, and CTGF...
  5. Peroxynitrite Decomposition Catalyst and Nitric Oxide Donor for Endotoxemia
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..neutrophil infiltration, 3- nitrotyrosine (3-NT), nitrite/nitrate, and poly(ADP-ribose) formation, BUN, creatinine, NGAL, AST, ALT, histology injury score, and serum concentrations of TNF-1, HMGB-1, IL-6, TRP14, Trx1, LC8, I:B1, IL-12, ..
  6. A Hybrid Katp Channel Opener to Prevent Radiocontrast-Induced Nephropathy
    Kanneganti Murthy; Fiscal Year: 2012
    ..by the concentration of urinary Kidney Injury Molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL)...
  7. Edward B Garon; Fiscal Year: 2015
    ..collected as part of the clinical trial for biologic markers, including estradiol and investigational biomarkers NGAL and MMP-9, and 3) I will evaluate tissue collected as part of the clinical trial for correlative secondary ..
  8. Sushrut S Waikar; Fiscal Year: 2016
    ..kidney injury molecule-1 (KIM-1);N-acetyl-beta-D-glucosaminidase (NAG);neturophil gelatinase-associated lipocalin (NGAL);urinary L-type fatty acid binding protein (L-FABP);interleukin-18 (1L-18);urinary cystatin C;albumin;hepatocyte ..
  9. Urinary Biomarkers for Recovery After Acute Kidney Injury and Prognosis in Hospit
    ISAAC ELI HALL; Fiscal Year: 2010
    ..batched measurement of biomarkers such as interleukin-18 (IL-18), neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), and cystatin C...
  10. MARK EDWARD WESTERMAN; Fiscal Year: 2014
    ..g. serum creatinine) in AKI are very late markers (1-3 days) for diagnosis of AKI. Few biomarkers (e.g. NGAL, KIM-1) are commercially available for early prediction of AKI...
  11. Matam Vijay Kumar; Fiscal Year: 2015
    ..biologic activity of Lcn2 (as well as that of its human ortholog, Neutrophil Gelatinase-Associated Lipocalin) or NGAL suggests it may play a central role in IBD...
  12. Biomarkers in Acute Kidney Injury
    Joseph Bonventre; Fiscal Year: 2009
    ..potential biomarkers of AKI: kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), matrix metalloproteinase-9 (MMP-9), glutathione-S-transferases (alpha and pi-GST), actin, interleukin-18 (IL-18), ..
  13. Chirag R Parikh; Fiscal Year: 2016
    ..results on several novel urine and plasma biomarkers of kidney injury, such as urine IL-18, urine and plasma NGAL, urine albumin, plasma BNP, and plasma cystatin C...
  14. "Validation of Novel CKD Biomarkers in CRIC"
    Kathleen D Liu; Fiscal Year: 2013
    ....
  15. Subclinical and clinical heart disease and the effect on kidney injury and diseas
    Meyeon Park; Fiscal Year: 2013
    ..novel urinary biomarkers such as kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) may allow differentiation between different etiologies of rise in creatinine experienced by patients with heart ..
  16. Comparative Evaluation of Urinary Biological Markers for the Prognostic Stratific
    Bertrand Jaber; Fiscal Year: 2009
    ..Kidney Injury Molecule-1 (KIM-1) (a tubular dedifferentiation marker), Neutrophil Gelatinase-Associated Lipocalin (NGAL) (a tubular proliferation marker), interleukin-18 (IL-18) (a mediator of tubular ischemic injury), N-acetyl-(-D-..
  17. Radiocontrast Nephropathy: Redox Degradation Catalyst and Nitric Oxide Donor
    ZSUZSANNA KINGA ZSENGELLER; Fiscal Year: 2013
    ..RIRI), IV administration of R-100 prior to reperfusion reduced the 6 h elevations in serum creatinine, serum NGAL, tissue myeloperoxidase, and histologic score by 75-90% (p<10-14) and restored the reduction of creatinine ..
  18. A Thioredoxin Mimetic for Radiocontrast Nephropathy
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..We now propose to test this agent in a clinically-relevant small animal model of radiocontrast-induced kidney failure. ..
  19. Early diagnosis of acute kidney injury by aptasensors
    Muslum Ilgu; Fiscal Year: 2013
    ..of aptamer technology with microcantilever detection of serum/urine neutrophil gelatinase-associated lipocalin (NGAL), an early marker of AKI [2-4 hours at the onset of AKI with cutoff concentration of ~ 150 ng/ml (6.8 nM)]...
  20. NGAL: A novel early biomarker of acute renal injury
    Prasad Devarajan; Fiscal Year: 2005
    ..We have recently identified Neutrophil Gelatinase-Associated Lipocalin (NGAL) as a protein that is markedly induced in kidney tubule cells very early after ischemia, and rapidly secreted into ..
  21. Urinary Biomarkers for Acute Kidney Injury in Critical Illness
    Steven Coca; Fiscal Year: 2007
    ..Urinary IL-18, neutrophil gelatinase- associated lipocalin (NGAL), and cystatin C are three promising biomarkers for the early detection and potential risk-stratification of AKI...
  22. Towards Measures of Lupus Nephritis Activity &Damage for Children
    Hermine I Brunner; Fiscal Year: 2012
    ..e. neutrophil gelatinase associated lipocalin, transferrin, ceruloplasmin, al-acid glycoprotein, chemokine ligand 2, adiponectin, hepcidin, ..
  23. Biomarkers in Acute Kidney Injury
    Joseph Bonventre; Fiscal Year: 2006
    ..potential biomarkers of AKI: kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), matrix metalloproteinase-9 (MMP-9), glutathione-S-transferases (alpha and pi-GST), actin, interleukin-18 (IL-18), ..
  24. The Renal Pathogenicity of Anti-DNA Antibodies
    Chaim Putterman; Fiscal Year: 2013
    ..binding to MC (-actinin directly modulated inflammatory gene expression including cytokines and neutrophil gelatinase associated lipocalin (NGAL, lipocalin-2), via Fc-dependent and independent mechanisms...
  25. Analysis of NGAL Metabolism Identifies a Therapy for Iron Overload
    Jonathan M Barasch; Fiscal Year: 2012
    ..We found that a member of the lipocalin superfamily called Ngal acted as a high affinity iron carrier (Barasch, Molecular Cell, 2002) when binding a family of novel cofactors ..
  26. Prevention of Acute Lung Injury by IL-6 activated STAT3
    Ana Moran; Fiscal Year: 2010
    ..Stat3 were genes encoding proteins that are known to be expressed by epithelial cells-Glp1r, Pik3r1 and Lcn2-as well as genes encoding proteins- Gzmb and Prf1-that are expressed by neutrophils, macrophages and cytotoxic T-..
  27. Jonathan M Barasch; Fiscal Year: 2015
    ..We discovered that the NGAL (Lipocalin2) gene is expressed by the TALH and the Collecting Ducts between three-six hours after damage, and its ..
  28. SDF-1: A Diagnostic and Therapy-Specific Biomarker of AKI and CKD
    Christof Westenfelder; Fiscal Year: 2013
    ..CKD models in rats, temporal SDF-1 profiles in serum, kidney and urine are defined and correlated with function and NGAL levels...
  29. Role of the Mammalian Siderophore in Cellular Iron Metabolism and Erythropoiesis
    Laxminarayana R Devireddy; Fiscal Year: 2012
    ..with low-molecular-weight siderophores and this liganded iron is a target for carrier proteins such as lipocalin 24p3. 24p3 is a member of the lipocalin family a group of carrier proteins that bind and transport a variety of ligands ..
  30. W Ray Kim; Fiscal Year: 2015
    ....
  31. Intercalated Cells of the Distal Nephron Defend the Urinary System
    Neal Paragas; Fiscal Year: 2013
    ..the distal tubule detects and secretes a bacteriostatic molecule called neutrophil gelatinase-associated lipocalin (NGAL)...
  32. RONALD MARK PAYNE; Fiscal Year: 2015
    ..Our research team identified neutrophil gelatinase-associated lipocalin (NGAL) as a diagnostic biomarker and showed that plasma and urine NGAL levels 2 hours after initiation of CPB reliably ..
  33. YALE CENTER FOR THE STUDY OF POLYCYSTIC KIDNEY DISEASE
    Stefan Somlo; Fiscal Year: 2009
    ..signaling in regulating the morphogenic events that mediate tubule formation, and will explore the ability of Ngal to modify these signals and thereby suppress cyst formation in vivo...
  34. CYTOKINES CONVERT EPITHELIAL PRECURSORS TO NEPHRONS
    Jonathan M Barasch; Fiscal Year: 2010
    ..The inductive factors included LIF, lipocalin-2 (Ngal, the most highly expressed factor in acute renal failure), a fragment of urokinase (unpublished) and a partially ..
  35. The New York CKD Biomarker Discovery Program
    Erwin P Bottinger; Fiscal Year: 2013
    ..discovery work by our groups, 78 candidate biomarkers, including neutrophil gelatinaseassociated lipocalin (LCN2 or NGAL), a urinary biomarker for acute kidney injury, were identified by genomewide transcriptional profiling and ..
  36. Mechanistic Studies of MUC4 and NGAL in Pancreatic Adenocarcinoma
    MICHAEL JAMES BAINE; Fiscal Year: 2012
    ..microarrays containing well characterized tumors tissues, we observed elevated expression of neutrophil gelatinase associated lipocalin (NGAL), also known as Lipocalin 2 or uterocalin, during pancreatic cancer progression...
  37. Lipocalin 2 in Inflammation and Metabolic Control
    Xiaoli Chen; Fiscal Year: 2012
    ..Through the proteomics and microarray screening, we recently identified lipocalin 2 (LCN2) as a new adipokine that potentially connects obesity and insulin resistance...
  38. Personalized therapeutics for inhibiting breast cancer metastasis
    DEBRA AUGUSTE; Fiscal Year: 2012
    ..In addition, lipocalin-2 (Lcn2) has been shown to induce the epithelial to mesenchymal transition (EMT)...
  39. Molecular regulation of breast cancer growth
    Marsha A Moses; Fiscal Year: 2010
    ..We have recently identified the presence of NGAL (Neutrophil Gelatinase- Associated Lipocalin) both alone, and complexed to the gelatinase MMP-9, in the urine of ..
  40. Coordination Chemistry of Microbial Iron Transport Compounds
    Kenneth N Raymond; Fiscal Year: 2013
    ..Through the use of synthetic analogs and bacterial siderophore isolates, as well as labeled substrates and mutant proteins, we intend to describe the selectivity and physiological course of siderocalin. ..
  41. The host mucosal response to microbial iron metabolism
    MICHAEL ABBOTT BACHMAN; Fiscal Year: 2013
    ..By understanding the mechanism of siderocalin function, we can potentially develop novel therapeutics to enhance mucosal immunity or inhibit bacterial strategies that thwart it. ..
  42. Lipocalin 2 in Inflammation and Metabolic Control
    Xiaoli Chen; Fiscal Year: 2013
    ..Our lab has been characterizing metabolic functions of lipocalin 2 (Lcn2), a newly identified adipokine preferentially abundant in WAT...
  43. Role of Lipocalin 24p3 in Apoptosis and Leukemia
    Laxminarayana R Devireddy; Fiscal Year: 2010
    ..Recent work demonstrated that loss of cytokine signaling triggers the secretion of lipocalin 24p3, which then binds to a cell-surface receptor and induces apoptosis...
  44. Helicobacter pylori and the gastric microbial community in rhesus macaques
    Jay V Solnick; Fiscal Year: 2010
    ..We hypothesize that this antimicrobial response alters the gastric microbial community and increases the competitive advantage of H. pylori in the gastric niche. ..
  45. Aravamudan S Gopalan; Fiscal Year: 2016
    ..These conjugates can be then used as mechanistic probes to study iron transport or even as potential vehicles to deliver desired drugs into the organism. ..
  46. Neutrophil gelatinase-associated lipocalin mediated retinoid effects in the skin
    KIMBERLY R LUMSDEN; Fiscal Year: 2010
    ..of treatment with 13-cis RA is lipocalin 2 (Icn2), which encodes the neutrophil-gelatinase associated lipocalin (NGAL) protein...
  47. Identifying acute tubular necrosis in cirrhosis patients with renal dysfunction
    Chirag R Parikh; Fiscal Year: 2010
    ..Two of these promising biomarkers are interleukin-18 (IL-18) and neutrophil gelatinase associated lipocalin (NGAL) that have been shown to have an diagnostic accuracy of >90% in identifying ATN in the ..
  48. STRUCTURAL STUDIES OF RECEPTORS IN MUCUOSAL IMMUNITY
    Roland Strong; Fiscal Year: 2000
    ..responses in the mucosal compartment by: 1) determining the three-dimensional structure of Neutrophil Gelatinase Associated Lipocalin; 2) characterizing the interaction between the Polymeric Immunoglobulin Receptor and its ligand/..
  49. Role of Lipocalin 24p3 in Apoptosis and Leukemia
    Michael R Green; Fiscal Year: 2010
    ..This application focuses on the 24p3/24p3R transcriptionally-regulated proapoptotic pathway that our laboratory discovered and has been studying for the ..
  50. ACUTE RENAL FAILURE--IMPACT OF FLUORINATED ANESTHETICS
    RICHARD ZAGER; Fiscal Year: 2001
    ....
  51. Iron Therapy in Renal Disease: Potential Toxicities
    RICHARD ZAGER; Fiscal Year: 2008
    ..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
  52. Melatonin Supplementation in Hypertensive Patients
    FRANK SCHEER; Fiscal Year: 2007
    ..Furthermore, supplementation of suppressed nighttime melatonin levels may lead to a novel strategy in the treatment of essential hypertension. [unreadable]..
  53. Human monoclonal antibody therapy for HUS
    Howard Trachtman; Fiscal Year: 2004
    ..abstract_text> ..
  54. Small Molecule Therapeutics for Myocardial Ischemia
    Prakash Narayan; Fiscal Year: 2007
    ..A small molecule growth factor therapeutic that is cardioprotective has tremendous clinical benefit. [unreadable] [unreadable] [unreadable]..
  55. Novel Small Molecule Adjuvants to Drug-eluting Stents
    Prakash Narayan; Fiscal Year: 2008
    ..A small molecule therapeutic that reduces restenosis has tremendous clinical benefit. [unreadable] [unreadable] [unreadable]..
  56. Consequences of Chronic Renal Insufficiency
    Chi yuan Hsu; Fiscal Year: 2006
    ..These will contribute greatly to my development into an independent investigator. ..
  57. Novel Small Molecules For Acute Liver Failure
    Prakash Narayan; Fiscal Year: 2007
    ..Acute liver failure remains a significant cause of morbidity and mortality. A small molecule hepatocyte growth factor mimetic that is hepatoprotective is of tremendous clinical benefit. [unreadable] [unreadable] [unreadable]..
  58. Linking acute, chronic and end-stage renal disease
    Chi yuan Hsu; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  59. International Network and Registry for TMA
    Howard Trachtman; Fiscal Year: 2007
    ..These include essential hypertension, diabetes, hyperlipidemia, myocardial infarction, and chronic kidney disease. [unreadable] [unreadable]..
  60. Jak2 involvement in Bcr-Abl oncogenic transformation
    Ralph Arlinghaus; Fiscal Year: 2005
    ..g. use of DN SH2-Bbeta) in Bcr-Abl-induced oncogenic effects. These studies will provide important new information on mechanism of Bcr-Abl positive leukemia, and will provide new strategies for therapy of these leukemias. ..
  61. Renal Injury Prevention by SF/HGF-like Small Molecules
    Prakash Narayan; Fiscal Year: 2004
    ..Successful completion of the proposed studies is expected to provide sufficient data to seek regulatory approval for initiation of clinical trials of C6. ..
  62. Matrix metalloproteinase-9 mediated cell death in stroke
    ENG LO; Fiscal Year: 2009
    ..Our lab and others have established MMP-9 as a key extracellular protease that modifies neurovascular homeostasis. These proposed studies should help reveal the mechanisms of MMP-9 mediated cell death in stroke. ..
  63. KUPFFER CELLS AND CHEMICAL TOXICITY
    Debra Laskin; Fiscal Year: 2009
    ..Mechanistic insights derived from these studies may suggest new therapeutic approaches in the treatment of acute liver injury induced by acetaminophen. ..
  64. ENDOTHELIAL BARRIER FUNCTION IN PREECLAMPSIA
    Yuping Wang; Fiscal Year: 2010
    ..The influence of CLP on placental sFlt-1 will be studied. Results obtained from the proposed work should enhance current knowledge of the role of the placenta and EC dysfunction in the pathogenesis of PE. ..
  65. MATRIX METALLOPROTEINASE AND APOPTOSIS IN BRAIN TRAUMA
    ENG LO; Fiscal Year: 2004
    ..To date, there are not effective treatments for traumatic brain injury. Results from these proposed experiments will help identify MMP and upstream MAP kinase pathways as viable therapeutic targets for this devastating condition. ..
  66. Symposium on Tissue Remodeling
    Marit Nilsen Hamilton; Fiscal Year: 2003
    ..As has happened in past symposia, we also expect future symposia to promote exchanges of new ideas and the initiation of new collaborations. ..
  67. tPA plus MMP inhibition for combination stroke therapy
    Eng H Lo; Fiscal Year: 2010
    ..abstract_text> ..
  68. TWO NOVEL CPLA2 BINDING PROTEINS AND CELL DEATH
    JOSEPH VINCENT BONVENTRE; Fiscal Year: 2010
    ..Given the large number of patients that are initiated on dialysis each year, this addresses a critical public health problem. ..
  69. ALTERED NEUTROPHIL APOPTOSIS /BRONCHOPULMONARY DYSPLASIA
    Barry Weinberger; Fiscal Year: 2006
    ..The identification of specific pathways mediating apoptosis that are altered in neonatal neutrophils may also suggest preventive therapeutic strategies. ..
  70. TRIPTORELIN FOR OVARY PROTECTION IN CHILDHOOD LIPUS
    Hermine Brunner; Fiscal Year: 2007
    ..Abstract Not Provided ..
  71. CD47 as a neurovascular target for stroke therapy
    Eng H Lo; Fiscal Year: 2010
    ..Proof-of-concept data collected here may lead to the development of CD47 as a novel neurovascular target for stroke therapy. ..
  72. MECHANISMS OF HEMORRHAGE AND EDEMA IN TPA STROKE THERAPY
    ENG LO; Fiscal Year: 2006
    ..This proposal should fit the goals of the Stroke PRG because it examines novel mechanisms that link tPA, cell signaling, MMPs, and hemorrhagic transformation in the neurovascular unit. ..
  73. Coupled Biological and Mathematical Model of Neuronal P
    Marit Nilsen Hamilton; Fiscal Year: 2007
    ..This interdisciplinary approach will provide fundamental insights into the process of stem cell behavior during tissue integration. [unreadable] [unreadable]..
  74. MITOCHONDRIAL CALPAIN MEDIATED RENAL CELL DEATH
    RICK SCHNELLMANN; Fiscal Year: 2007
    ..Ultimately, these studies may lead to the development of therapeutic agents that improve clinical outcomes in patients with ARF. [unreadable] [unreadable]..
  75. Functional Dissection of Ret Signaling Pathways
    Sanjay Jain; Fiscal Year: 2008
    ..The identification of specific components of this signaling pathway will be helpful ultimately in developing targeted therapeutics for these tumors and in enhancing our understanding of nervous system development. ..
  76. Drugcarts to Combat Drug Resistance
    Marit Nilsen Hamilton; Fiscal Year: 2008
    ..The specificity of this delivery mechanism for cells that express PSMA and to promote cell death will be investigated. [unreadable] [unreadable] [unreadable] [unreadable]..
  77. LPS-specific Aptamers for Microbial Detection
    Marit Nilsen Hamilton; Fiscal Year: 2004
    ..abstract_text> ..
  78. The Renal Pathogenicity of Anti-DNA Antibodies
    Chaim Putterman; Fiscal Year: 2008
    ..binding to MC a-actinin directly modulated inflammatory gene expression including cytokines and neutrophil gelatinase associated lipocalin (NGAL, lipocalin), via Fc-dependent and independent mechanisms...
  79. IDENTIFICATION OF NEURONAL RECEPTOR SUBUNITS IN KIDNEY
    RICK SCHNELLMANN; Fiscal Year: 2001
    ..abstract_text> ..
  80. Novel Phospholipase A2 in Oxidant-Induced Cell Injury
    Rick G Schnellmann; Fiscal Year: 2010
    ..Ultimately, these studies may lead to new therapeutic and pharmacological approaches to increase cell and organ survival in numerous pathologic situations. ..