LAT2

Summary

Gene Symbol: LAT2
Description: linker for activation of T-cells family member 2
Alias: HSPC046, LAB, NTAL, WBSCR15, WBSCR5, WSCR5, linker for activation of T-cells family member 2, Williams-Beuren syndrome chromosomal region 15 protein, Williams-Beuren syndrome chromosomal region 5 protein, linker for activation of B-cells, linker for activation of T cells, transmembrane adaptor 2, membrane-associated adapter molecule, non-T-cell activation linker
Species: human

Top Publications

  1. ncbi Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients
    L R Osborne
    Department of Genetics, The Hospital for Sick Children, Toronto, Ontario, Canada
    Genomics 36:328-36. 1996
  2. ncbi Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23
    D W Martindale
    Department of Biology, Centre for Environmental Health, P O Box 3020, University of Victoria, Victoria, British Columbia, V8W 3N5 Canada
    Mamm Genome 11:890-8. 2000
  3. ncbi Effects of corn oil, time-related changes, and inter-laboratory variability on tumor occurrence in control Fischer 344 (F344/N) rats
    J K Haseman
    Division of Biometry and Risk Assessment, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709
    Toxicol Pathol 20:52-60. 1992
  4. ncbi [Rapid detection of Escherichia coli 0157:H7 in feces by latex agglutination and immunochromatographic assay]
    M Komatsu
    Department of Clinical Pathology, Tenri Hospital
    Kansenshogaku Zasshi 71:1124-30. 1997
  5. ncbi Intra-articular fractures of the distal end of the radius treated with an adjustable fixator system
    R M Zanotti
    Section of Orthopaedic Surgery, University of Michigan Hospitals, Ann Arbor 48109 0328, USA
    J Hand Surg Am 22:428-40. 1997
  6. ncbi Nightcap: a home-based sleep monitoring system
    A Mamelak
    Laboratory of Neurophysiology, Harvard Medical School, Boston, Massachusetts 02115
    Sleep 12:157-66. 1989
  7. ncbi Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters
    Ellappan Babu
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181 8611, Japan
    J Biol Chem 278:43838-45. 2003
  8. ncbi [Little known activity of the Czestochowa typhus Institute in 1943 and 1944]
    P Aramowicz
    Katedra Historii Medycyny i Farmacji, Wierzbowa
    Arch Hist Filoz Med 59:85-90. 1996
  9. ncbi Identification and characterization of a Na(+)-independent neutral amino acid transporter that associates with the 4F2 heavy chain and exhibits substrate selectivity for small neutral D- and L-amino acids
    Y Fukasawa
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181 8611, Japan
    J Biol Chem 275:9690-8. 2000
  10. ncbi The rape exam: beyond the hospital emergency room
    P Y Martin
    Florida State University School of Social Work, Tallahassee 32306
    Women Health 12:5-28. 1987

Research Grants

  1. Development of a mouse model of obesity in pregnancy
    Thomas Jansson; Fiscal Year: 2009
  2. METHYLMERCURY TRANSPORT ACROSS CELL MEMBRANES
    Nazzareno Ballatori; Fiscal Year: 2005
  3. Acetylcysteine: An Antidote for Methylmercury Poisoning
    TRACEY SIMMONS WILLIS; Fiscal Year: 2003
  4. Adaptor molecules in lymphocyte signaling
    Weiguo Zhang; Fiscal Year: 2007
  5. ESTROGEN BIOSYNTHESIS AND UTERINE LEIOMYOMATA
    Serdar Bulun; Fiscal Year: 2007
  6. MECHANISMS OF ESTROGEN BIOSYNTHESIS IN ENDOMETRIOSIS
    Serdar Bulun; Fiscal Year: 2008
  7. Breast Cancer-Proximal Stroma Interaction & Aromatase
    Serdar E Bulun; Fiscal Year: 2010

Scientific Experts

Detail Information

Publications173 found, 100 shown here

  1. ncbi Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients
    L R Osborne
    Department of Genetics, The Hospital for Sick Children, Toronto, Ontario, Canada
    Genomics 36:328-36. 1996
    ..LIMK1 and WSCR1 may be particularly relevant when explaining cognitive defects observed in WS patients...
  2. ncbi Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23
    D W Martindale
    Department of Biology, Centre for Environmental Health, P O Box 3020, University of Victoria, Victoria, British Columbia, V8W 3N5 Canada
    Mamm Genome 11:890-8. 2000
    ..Evidence was also found for WBSCR5 in this region, but not the previously proposed genes WSCR2 and WSCR6...
  3. ncbi Effects of corn oil, time-related changes, and inter-laboratory variability on tumor occurrence in control Fischer 344 (F344/N) rats
    J K Haseman
    Division of Biometry and Risk Assessment, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709
    Toxicol Pathol 20:52-60. 1992
    ..control data are to be utilized in the interpretation of experimental results, primary emphasis should be given to lab and route of administration-specific tumor rates for studies that are contemporary to the study under evaluation...
  4. ncbi [Rapid detection of Escherichia coli 0157:H7 in feces by latex agglutination and immunochromatographic assay]
    M Komatsu
    Department of Clinical Pathology, Tenri Hospital
    Kansenshogaku Zasshi 71:1124-30. 1997
    The rapid detection method of Escherichia coli O157 in feces by using the latex agglutination test kit (Prolex; Pro Lab Diagnostics) and the immunochromatic assay kit (NOW EH. E. coli; Binax) was studied...
  5. ncbi Intra-articular fractures of the distal end of the radius treated with an adjustable fixator system
    R M Zanotti
    Section of Orthopaedic Surgery, University of Michigan Hospitals, Ann Arbor 48109 0328, USA
    J Hand Surg Am 22:428-40. 1997
    ..in 16 adults (mean age, 34 years) were treated with the Wrist Jack external fixator system (Hand Biomechanics Lab, Sacramento, CA) and evaluated at a mean follow-up period of 25 months...
  6. ncbi Nightcap: a home-based sleep monitoring system
    A Mamelak
    Laboratory of Neurophysiology, Harvard Medical School, Boston, Massachusetts 02115
    Sleep 12:157-66. 1989
    ..Four subjects were monitored in the sleep lab with both our headgear and standard polysomnography...
  7. ncbi Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters
    Ellappan Babu
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181 8611, Japan
    J Biol Chem 278:43838-45. 2003
    ..Distinct from already known system L transporters LAT1 and LAT2, which form heterodimeric complex with 4F2 heavy chain, LAT3 was functional by itself in Xenopus oocytes...
  8. ncbi [Little known activity of the Czestochowa typhus Institute in 1943 and 1944]
    P Aramowicz
    Katedra Historii Medycyny i Farmacji, Wierzbowa
    Arch Hist Filoz Med 59:85-90. 1996
    ..plant employed there being no data left but according to employees still alive there must have been about a hundred lab. staff and two hundred feeders. The plant was divided into "breeding", "preparatory" and "liofilisation" sections...
  9. ncbi Identification and characterization of a Na(+)-independent neutral amino acid transporter that associates with the 4F2 heavy chain and exhibits substrate selectivity for small neutral D- and L-amino acids
    Y Fukasawa
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181 8611, Japan
    J Biol Chem 275:9690-8. 2000
    ..homology (66% identity at the amino acid level) to the Na(+)-independent broad scope neutral amino acid transporter LAT2 (Segawa, H., Fukasawa, Y., Miyamoto, K., Takeda, E., Endou, H., and Kanai, Y. (1999) J. Biol. Chem...
  10. ncbi The rape exam: beyond the hospital emergency room
    P Y Martin
    Florida State University School of Social Work, Tallahassee 32306
    Women Health 12:5-28. 1987
    ..2), a nonhospital-based SATC, a proprietary OB/GYN clinic, a medical examiner's office, and a law enforcement crime lab. Open-ended interviews indicate that major problems with hospitals as exam sites stem from physicians' dislike of ..
  11. ncbi Sleep in the laboratory and sleep at home: comparisons of older insomniacs and normal sleepers
    J D Edinger
    Veterans Affairs Medical Center, Durham, North Carolina 27705, USA
    Sleep 20:1119-26. 1997
    ..e. lab and home)...
  12. ncbi Characterization of the system L amino acid transporter in T24 human bladder carcinoma cells
    Do Kyung Kim
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Tokyo 181 8611, Mitaka, Japan
    Biochim Biophys Acta 1565:112-21. 2002
    ..membrane together with its associating protein 4F2hc, whereas T24 cells do not express the other system L isoform LAT2. The uptake of [14C]L-leucine by T24 cells is Na(+)-independent and almost completely inhibited by system L ..
  13. ncbi Full polysomnography in the home
    J M Fry
    Hahnemann School of Medicine, Allegheny University of the Health Sciences, Philadelphia, Pa. 19129, USA
    Sleep 21:635-42. 1998
    ..However, patients reported more sleep time and a better overall test experience in the lab. Assessments of sleep quality and morning alertness compared to usual were rated higher in the lab...
  14. ncbi Functional characterization of two S-nitroso-L-cysteine transporters, which mediate movement of NO equivalents into vascular cells
    Sheng Li
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Physiol Cell Physiol 292:C1263-71. 2007
    ..that uptake increased only when both 4F2 heavy chain (4F2HC) and either L-type amino acid transporter 1 (LAT1) or LAT2 light chain were coexpressed...
  15. ncbi [Diagnostic focus on the child with epilepsy and neuropsychological deterioration]
    A C Rodríguez-Barrionuevo
    Hospital Materno Infantil, Unidad de Neuropediatria, Carlos Haya, Malaga, Espana
    Rev Neurol 26:322-30. 1998
    ..the diagnosis of the hereditary metabolic and heredodegeneratives diseases can be made by the characteristics of the seizures but in most cases the diagnosis will be established by the symptoms of the basic disease and the lab data.
  16. doi Involvement of LAT1 and LAT2 in the high- and low-affinity transport of L-leucine in human retinal pigment epithelial cells (ARPE-19 cells)
    Atsushi Yamamoto
    Department of Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    J Pharm Sci 99:2475-82. 2010
    System L, which is encoded by LAT1 and LAT2, is an amino acid transport system that transports neutral amino acids, including several essential amino acids in an Na+-independent manner...
  17. ncbi Identification of stereoselective transporters for S-nitroso-L-cysteine: role of LAT1 and LAT2 in biological activity of S-nitrosothiols
    Sheng Li
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 280:20102-10. 2005
    ..To show that system L family members mediate uptake, we expressed two members, LAT1 and LAT2, in Xenopus oocytes...
  18. ncbi A study of L-leucine, L-phenylalanine and L-alanine transport in the perfused rat mammary gland: possible involvement of LAT1 and LAT2
    D B Shennan
    Hannah Research Institute, Ayr Scotland, UK
    Biochim Biophys Acta 1564:133-9. 2002
    ..Lactating rat mammary tissue was found to express both LAT1 and LAT2 mRNA...
  19. ncbi High- and low-affinity transport of L-leucine and L-DOPA by the hetero amino acid exchangers LAT1 and LAT2 in LLC-PK1 renal cells
    Patricio Soares-da-Silva
    Institute of Pharmacology and Therapeutics, Faculty of Medicine, 4200 319 Porto, Portugal
    Am J Physiol Renal Physiol 287:F252-61. 2004
    ..05) by L-cysteine, L-leucine, BCH, and L-DOPA but not by L-arginine. RT-PCR detected LAT1 and LAT2 transcripts in LLC-PK1 cells...
  20. ncbi Basolateral aromatic amino acid transporter TAT1 (Slc16a10) functions as an efflux pathway
    Tamara Ramadan
    Institute of Physiology and Centre for Integrative Human Physiology ZIHP, University of Zurich, Winterthurerstrasse, Zurich, Switzerland
    J Cell Physiol 206:771-9. 2006
    ..The best characterized basolateral amino acid transporters are y+LAT1-4F2hc and LAT2-4F2hc that function as obligatory exchangers and thus, do not contribute to net amino acid (re)absorption...
  21. ncbi Cloning and gene silencing of LAT2, the L-3,4-dihydroxyphenylalanine (L-DOPA) transporter, in pig renal LLC-PK1 epithelial cells
    Patricio Soares-da-Silva
    Institute of Pharmacology and Therapeutics, Faculty of Medicine, 4200 Porto, Portugal
    FASEB J 18:1489-98. 2004
    Organ-specific overexpression of type 2 L-amino acid transporter (LAT2) in the kidney of the spontaneous hypertensive rat (SHR), accompanied by an enhanced ability to take up L-DOPA, may constitute the basis for the enhanced renal ..
  22. ncbi [Randomized, comparative study on the treatment of moderate arterial hypertension during pregnancy: methyldopa, acebutolol, labetalol]
    H Lardoux
    Service de cardiologie, , Corbeil-Essonnes
    Arch Mal Coeur Vaiss 81:137-40. 1988
    ..antihypertensive sequence was to compare a betablocker with sympathomimetic activity (ACE) and an alphabetablocker (LAB) to the gold standard treatment (MD) in moderate HDP (BP greater than 90 mmHg)...
  23. ncbi System L-amino acid transporters are differently expressed in rat astrocyte and C6 glioma cells
    Do Kyung Kim
    Department of Oral Physiology, Chosun University College of Dentistry, 375 Seosuk dong, Dong Gu, Gwangju, 501 759, South Korea
    Neurosci Res 50:437-46. 2004
    ..The rat astrocyte cultures expressed the l-type amino acid transporter 2 (LAT2) with its subunit 4F2hc, whereas the l-type amino acid transporter 1 (LAT1) was not expressed in these cells...
  24. doi Hyperammonemia increases the expression and activity of the glutamine/arginine transporter y+ LAT2 in rat cerebral cortex: implications for the nitric oxide/cGMP pathway
    Magdalena Zielinska
    Department of Neurotoxicology, Mossakowski Medical Research Centre, Polish Academy of Sciences, Pawinskiego 5 Str, 02 106 Warsaw, Poland
    Neurochem Int 58:190-5. 2011
    ..study we demonstrate that a 3-day HA in the ammonium acetate model increases the expression in the brain of y(+)LAT2, the heteromeric transporter which preferentially stimulates Arg efflux from the cells in exchange for Gln...
  25. ncbi L-leucine transport in human breast cancer cells (MCF-7 and MDA-MB-231): kinetics, regulation by estrogen and molecular identity of the transporter
    D B Shennan
    Hannah Research Institute, Ayr, Scotland, KA6 5HL, UK
    Biochim Biophys Acta 1664:206-16. 2004
    ..Quantitative real-time PCR revealed that LAT1 mRNA was approximately 200 times more abundant than LAT2 mRNA in MCF-7 cells and confirmed that MDA-MB-231 cells express LAT1 but not LAT2 mRNA...
  26. ncbi Alanine metabolism, transport, and cycling in the brain
    Stefan Broer
    School of Biochemistry and Molecular Biology, Australian National University, Acton, Canberra ACT, Australia
    J Neurochem 102:1758-70. 2007
    ..Alanine uptake into astrocytes was largely mediated by system L isoform LAT2, whereas alanine uptake into neurons was mediated by Na(+)-dependent transporters with properties similar to system ..
  27. ncbi Nocturnal cluster headache associated with sleep apnea. A case report
    P Buckle
    Section of Respiratory Diseases, University of Manitoba, Winnipeg, Canada
    Sleep 16:487-9. 1993
    ..Following investigation in the sleep lab he was found to have obstructive sleep apnea (OSA) with associated oxygen desaturations during rapid eye movement (..
  28. ncbi Functional and molecular characteristics of system L in human breast cancer cells
    D B Shennan
    Hannah Research Institute, Ayr, Scotland KA6 5HL, UK
    Biochim Biophys Acta 1611:81-90. 2003
    ..MDA-MB-231 and MCF-7 cells expressed LAT1 and CD98 mRNA. MCF-7 cells also expressed LAT2 mRNA...
  29. ncbi The dopamine precursor L-dihydroxyphenylalanine is transported by the amino acid transporters rBAT and LAT2 in renal cortex
    HENRY QUINONES
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 8856, USA
    Am J Physiol Renal Physiol 287:F74-80. 2004
    ..yielded l-DOPA uptake significantly above water-injected controls the rBAT/b(0,+)AT dimer (rBAT) and the LAT2/4F2 dimer (LAT2)...
  30. ncbi Reabsorption of neutral amino acids mediated by amino acid transporter LAT2 and TAT1 in the basolateral membrane of proximal tubule
    Sun Young Park
    Department of Pediatrics, Kwangju Christian Hospital, Gwangju 503 715, Korea
    Arch Pharm Res 28:421-32. 2005
    ..Therefore, LAT2 and TAT1 play essential roles in the reabsorption of neutral amino acids from the epithelial cells to the blood ..
  31. ncbi Recycling of aromatic amino acids via TAT1 allows efflux of neutral amino acids via LAT2-4F2hc exchanger
    Tamara Ramadan
    Zurich Centre for Integrative Human Physiology, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland
    Pflugers Arch 454:507-16. 2007
    ..Because LAT2-4F2hc (Slc7a8-Slc3a2), the best known basolateral neutral amino acid transporter of these epithelial cells, ..
  32. ncbi Dietary protein quality and feed restriction influence abundance of nutrient transporter mRNA in the small intestine of broiler chicks
    Elizabeth R Gilbert
    Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    J Nutr 138:262-71. 2008
    ..amino acid transporter 3 (EAAT3), Na+-independent cationic and Na+-dependent neutral amino acid transporter (y+ LAT2), and Na+-independent cationic amino acid transporter 2 (CAT2)], glucose transporter [Na+-dependent glucose and ..
  33. pmc Regulation of system x(c)(-)activity and expression in astrocytes by interleukin-1β: implications for hypoxic neuronal injury
    Nicole A Jackman
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030 3401, USA
    Glia 58:1806-15. 2010
    ..IL-1β does not regulate the light chain of the amino acid transporter, LAT2, or the expression and function of astrocytic excitatory amino acid transporters (EAATs), demonstrating some target ..
  34. ncbi [Actigraphy: methodological limits for evaluation of sleep stages and sleep structure of healthy probands]
    R Conradt
    Schlafmedizinisches Labor der Medizinischen Poliklinik,
    Pneumologie 51:721-4. 1997
    ..6 +/- 3.3 kg/m2 participated in the study. All subjects were recorded in the sleep lab via cardiorespiratory polysomnography and wrist actigraphy (Ambulatory Monitoring, Ardsley, USA) worn on the non-..
  35. ncbi CD98 and intracellular adhesion molecule I regulate the activity of amino acid transporter LAT-2 in polarized intestinal epithelia
    Xia Liu
    Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 278:23672-7. 2003
    ..L. (2001) J. Biol. Chem. 276, 39282-39289). In the present study we examined the interaction of CD98/LAT2 with intracellular adhesion molecule I (ICAM-1) and the potential of such interaction on the activation of ..
  36. ncbi Establishment and characterization of mammalian cell lines stably expressing human L-type amino acid transporters
    Emiko Morimoto
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Japan
    J Pharmacol Sci 108:505-16. 2008
    ..Previously, we identified two isoforms of transporters: L-type amino acid transporter 1 (LAT1) and 2 (LAT2) and revealed their distinct substrate selectivity and transport properties...
  37. doi Vacuolin-1-modulated exocytosis and cell resealing in mast cells
    Gouse M Shaik
    Laboratory of Signal Transduction, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Cell Signal 21:1337-45. 2009
    ..Furthermore, our results support the concept that lysosomal exocytosis is involved in the repair of injured plasma membranes...
  38. ncbi Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins
    Iain C Macaulay
    Department of Haematology, University of Cambridge, Cambridge, UK
    Blood 109:3260-9. 2007
    ..Many of these transcripts, including G6b, G6f, LRRC32, LAT2, and the G protein-coupled receptor SUCNR1, encode proteins with structural features or functions that suggest they ..
  39. ncbi Functional activity of a large neutral amino acid transporter (LAT) in rabbit retina: a study involving the in vivo retinal uptake and vitreal pharmacokinetics of L-phenyl alanine
    Harisha Atluri
    Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri Kansas City, 5005 Rockhill Road, Kansas City, MO 64110 2499, USA
    Int J Pharm 347:23-30. 2008
    ..The purpose of this study is to elucidate the functional activity of large neutral amino acid transporter (LAT) in rabbit retina and to delineate its role in the retinal uptake and intravitreal pharmacokinetics of L-phenylalanine (L-Phe)...
  40. doi Properties of L-type amino acid transporter 1 in epidermal ovarian cancer
    Masahiko Kaji
    Department of Obstetrics and Gynecology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan
    Int J Gynecol Cancer 20:329-36. 2010
    ....
  41. ncbi An introduction to computerised speech lab
    K Van Lierde
    Department of Otorhinolaryngology, University Hospital, Ghent, Belgium
    Acta Otorhinolaryngol Belg 50:309-14. 1996
    ..This can be provided by a computerised technique, the computerised speech lab (CLS), which performs an acoustic analysis of the voice samples and gives objective figures of multiple parameters.
  42. ncbi Multiple pathways for cationic amino acid transport in rat thyroid epithelial cell line PC Cl3
    Tiziano Verri
    Laboratory of General Physiology, Department of Biological and Environmental Sciences and Technologies, University of Lecce, Lecce, Italy
    Am J Physiol Cell Physiol 288:C290-303. 2005
    ..Uptake data correlate to expression of the genes encoding for CAT-1, CAT-2B, 4F2hc, y(+)LAT1, y(+)LAT2, rBAT, and b(0,+)AT, an expression profile that is also shown by the rat thyroid gland...
  43. ncbi Fc gamma RII activation induces cell surface ceramide production which participates in the assembly of the receptor signaling complex
    Marek Korzeniowski
    The Nencki Institute of Experimental Biology, Department of Cell Biology, Warsaw, Poland
    Cell Physiol Biochem 20:347-56. 2007
    ..The effects of the drugs on the phosphorylation of Fc gamma RII and NTAL were prominent and correlated with a reduction of the cell surface ceramide production by imipramine and an ..
  44. pmc Drosophila expresses a CD98 transporter with an evolutionarily conserved structure and amino acid-transport properties
    Bruno Reynolds
    Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, U K
    Biochem J 420:363-72. 2009
    ..The heterodimeric complexes of CD98hc and the light chains LAT1 (L-type amino acid transporter 1) or LAT2 specifically promote sodium-independent System L exchange of neutral amino acids, including leucine...
  45. ncbi [Amino acid transporter molecule as a drug target]
    H Endou
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo, Japan
    Nihon Yakurigaku Zasshi 114:11P-16P. 1999
    ..As a homolog of LAT1, we also cloned LAT2 which is expressed in various normal tissues...
  46. doi LAT1 regulates growth of uterine leiomyoma smooth muscle cells
    - Xia Luo
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Reprod Sci 17:791-7. 2010
    L-type amino acid transporter 1 (LAT1) and LAT2 were shown to encode system L, which mediates the Na(+)-independent transport of branched-chain and aromatic amino acids...
  47. ncbi [Is SnorEx also ApneaEx? A study with a new intra-oral prosthesis as a form of therapy of obstructive sleep apnea syndrome]
    B Schonhofer
    Krankenhaus Kloster Grafschaft, Zentrum fur Pneumologie und Allergologie, Schmallenberg Grafschaft
    Pneumologie 51:804-8. 1997
    ..We performed the study to test the effectiveness of the device in reducing the number of obstructive events...
  48. doi Non-T cell activation linker (NTAL) proteolytic cleavage as a terminator of activatory intracellular signals
    Mikel M Arbulo-Echevarria
    Core Research Facility for Health Sciences, University of Cadiz and Puerto Real University Hospital Research Unit, Department of Biomedicine, Biotechnology and Public Health Immunology, Cadiz, Spain
    J Leukoc Biol 100:351-60. 2016
    ..Altogether, our results suggest that cleavage of transmembrane adaptors constitutes a general mechanism for signal termination of immune receptors. ..
  49. ncbi Evaluation of EEG cyclic alternating pattern during sleep in insomniacs and controls under placebo and acute treatment with zolpidem
    M G Terzano
    Department of Neurology, University of Parma, Italy
    Sleep 15:64-70. 1992
    ..After adaptation to the sleep lab, 18 subjects (12 with persistent psychophysiological insomnia and 6 without sleep complaints), all aged 40-60 years,..
  50. ncbi Assessment of accuracy and analysis time of a novel device to monitor sleep and breathing in the home
    D P White
    National Jewish Center, Denver V.A. Medical Center, CO 80220, USA
    Sleep 18:115-26. 1995
    ..Two separate studies were completed. NW was compared to a simultaneously obtained PSG in 30 patients (IN-LAB study)...
  51. pmc Association of 4F2hc with light chains LAT1, LAT2 or y+LAT2 requires different domains
    A Bröer
    Division of Biochemistry and Molecular Biology, Faculty of Science, Australian National University, Canberra, ACT 0200, Australia
    Biochem J 355:725-31. 2001
    ..light chains, C-terminally truncated mutants of 4F2hc were constructed and co-expressed with the light chains LAT1, LAT2 and y(+)LAT2...
  52. ncbi Function and structure of heterodimeric amino acid transporters
    C A Wagner
    Department of Cellular and Molecular Physiology, School of Medicine, Yale University, New Haven, Connecticut 06520, USA
    Am J Physiol Cell Physiol 281:C1077-93. 2001
    ..whereas the homologous heavy chain 4F2hc interacts with several light chains to form system L (with LAT1 and LAT2), system y(+)L (with y(+)LAT1 and y(+)LAT2), system x (with xAT), or system asc (with asc1)...
  53. ncbi Sleep in the laboratory and sleep at home II: comparisons of middle-aged insomnia sufferers and normal sleepers
    J D Edinger
    VA and Duke University Medical Centers, Durham, NC 27705, USA
    Sleep 24:761-70. 2001
    ..compared adaptation responses and sleep pattern differences shown by normal sleepers and insomnia sufferers during lab (LPSG) and home (HPSG) polysomnography. DESIGN: A counter-balanced, matched-group design was used...
  54. ncbi Two-way arginine transport in human endothelial cells: TNF-alpha stimulation is restricted to system y(+)
    Roberto Sala
    Dipartimento di Medicina Sperimentale, Sezione di Patologia Generale e Clinica, Universita degli Studi di Parma, 43100 Parma, Italy
    Am J Physiol Cell Physiol 282:C134-43. 2002
    ..NEM), inhibited by L-leucine in the presence of Na(+), and referable to the expression of SLC7A6/y(+)LAT2, SLC7A7/y(+)LAT1, and SLC3A2/4F2hc. System y(+) is referable to the expression of SLC7A1/CAT1 and SLC7A2/CAT2B...
  55. ncbi Relationship of slow and rapid EEG components of CAP to ASDA arousals in normal sleep
    L Parrino
    , Parma, Italia
    Sleep 24:881-5. 2001
    ..SETTING: 40 sleep-lab accomplished recordings. PARTICIPANTS: Healthy subjects belonging to a wide age range (38 +/- 20 yrs.)...
  56. ncbi Protein kinase activity is central to rat germ cell apoptosis induced by methoxyacetic acid
    T Jindo
    Reproductive Toxicology Group, National Toxicology Program, NIEHS, Research Triangle Park, North Carolina, USA
    Toxicol Pathol 29:607-16. 2001
    ..Preliminary data from this lab suggested the involvement of protein kinase activity in the development of this lesion, a hypothesis explored in ..
  57. ncbi System L: heteromeric exchangers of large, neutral amino acids involved in directional transport
    Francois Verrey
    University of Zurich, Institute of Physiology, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Pflugers Arch 445:529-33. 2003
    ..The corresponding transporters are hetero(di)mers composed of a catalytic subunit (LAT1 or LAT2=light chain=glycoprotein-associated amino acid transporter) associated covalently with the glycoprotein 4F2hc/CD98 (..
  58. ncbi Adaptors and linkers in T and B cells
    Luca Simeoni
    Institute of Immunology, Otto von Guericke University Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Curr Opin Immunol 16:304-13. 2004
    ..Additional transmembrane adaptors, such as NTAL/LAB and LIME, have been identified and partially characterized...
  59. pmc Expression of heteromeric amino acid transporters along the murine intestine
    Mital H Dave
    Institute of Physiology, University of Zurich, Winterthurerstr 190, CH 8057 Zurich, Switzerland
    J Physiol 558:597-610. 2004
    ..Immunohistochemistry demonstrated basolateral coexpression of 4F2hc, LAT2 and y(+)-LAT1 in stomach and small intestine, whereas rBAT and b degrees (,+)AT were found colocalizing on the ..
  60. pmc Positive and negative regulation of FcepsilonRI-mediated signaling by the adaptor protein LAB/NTAL
    Minghua Zhu
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Exp Med 200:991-1000. 2004
    b>Linker for activation of B cells (LAB, also called NTAL; a product of wbscr5 gene) is a newly identified transmembrane adaptor protein that is expressed in B cells, NK cells, and mast cells...
  61. ncbi Expression and function of glutamine transporters SN1 (SNAT3) and SN2 (SNAT5) in retinal Müller cells
    Nagavedi S Umapathy
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, 30912, USA
    Invest Ophthalmol Vis Sci 46:3980-7. 2005
    ..the glutamine transporters ATA1 and ATA2 (isoforms of system A), SN1 and SN2 (isoforms of system N), and LAT1 and LAT2 (isoforms of system L) were investigated in Müller cells in a rat Müller cell line (rMC1) and primary cultures of ..
  62. ncbi Expression and adaptive regulation of amino acid transport system A in a placental cell line under amino acid restriction
    H N Jones
    Maternal Fetal Physiology, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
    Reproduction 131:951-60. 2006
    ..014) decrease in the expression of SNAT1 mRNA. System L type amino acid transporter 2 (LAT2) expression was not changed by amino acid restriction, indicating that the responses seen in the system A ..
  63. ncbi Negative regulation of T cell activation and autoimmunity by the transmembrane adaptor protein LAB
    Minghua Zhu
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Immunity 25:757-68. 2006
    LAB (linker for activation of B cells), also known as NTAL (non-T cell activation linker), is a LAT (linker for activation of T cells)-like adaptor protein that is expressed in B, NK, and mast cells...
  64. ncbi Ornithine transport via cationic amino acid transporter-1 is involved in ornithine cytotoxicity in retinal pigment epithelial cells
    Shiho Kaneko
    Department of Ophthalmology, Kansai Medical University, Osaka, Japan
    Invest Ophthalmol Vis Sci 48:464-71. 2007
    ..This study was intended to clarify the mechanism of ornithine cytotoxicity and to determine the responsible amino acid transporters...
  65. ncbi Non-T cell activation linker promotes mast cell survival by dampening the recruitment of SHIP1 by linker for activation of T cells
    Karine Roget
    Institut Pasteur, Departement d Immunologie, Unité d Allergologie Moléculaire et Cellulaire, Paris, France
    J Immunol 180:3689-98. 2008
    The linker for activation of T cells (LAT) and the non-T cell activation linker (NTAL) are two transmembrane adapters which organize IgE receptor (FcepsilonRI) signaling complexes in mast cells...
  66. doi Glutamine inhibits ammonia-induced accumulation of cGMP in rat striatum limiting arginine supply for NO synthesis
    Wojciech Hilgier
    Department of Neurotoxicology, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
    Neurobiol Dis 35:75-81. 2009
    ..The L-arginine co-substrates of y(+)LAT2 transport system, L-leucine and cyclo-leucine, mimicked the effect of exogenous Gln, suggesting that Gln limits Arg ..
  67. pmc Progesterone and mifepristone regulate L-type amino acid transporter 2 and 4F2 heavy chain expression in uterine leiomyoma cells
    Xia Luo
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Clin Endocrinol Metab 94:4533-9. 2009
    ..Previously, using chromatin immunoprecipitation-based cloning, we uncovered L-type amino acid transporter 2 (LAT2) as a novel PR target gene...
  68. pmc The linker for activation of B cells (LAB)/non-T cell activation linker (NTAL) regulates triggering receptor expressed on myeloid cells (TREM)-2 signaling and macrophage inflammatory responses independently of the linker for activation of T cells
    Gillian C Whittaker
    Cancer and Inflammation Program, Center for Cancer Research, NCI Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
    J Biol Chem 285:2976-85. 2010
    ..is severely reduced as monocytes differentiate into macrophages and that TREM-2 exclusively uses the linker for activation of B cells (LAB encoded by the gene Lat2(-/-)) to mediate downstream signaling...
  69. pmc LAB/NTAL/Lat2: a force to be reckoned with in all leukocytes?
    Selinda J Orr
    Cancer and Inflammation Program, National Cancer Institute Frederick, Frederick, MD 21702, USA
    J Leukoc Biol 89:11-9. 2011
    LAB/NTAL/Lat2 is a transmembrane adaptor protein closely related to LAT. It is expressed in various myeloid and lymphoid cells, many of which also express LAT...
  70. pmc The expression of thyroid hormone transporters in the human fetal cerebral cortex during early development and in N-Tera-2 neurodifferentiation
    S Y Chan
    School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Floor 3, Birmingham Women s Hospital, Edgbaston, Birmingham B15 2TG, UK
    J Physiol 589:2827-45. 2011
    ..Compared with adult cortex, mRNAs encoding OATP1A2, OATP1C1, OATP3A1 variant 2, OATP4A1, LAT2 and CD98 were reduced in fetal cortex at different gestational ages, whilst mRNAs encoding MCT8, MCT10, OATP3A1 ..
  71. doi Aminoaciduria, but normal thyroid hormone levels and signalling, in mice lacking the amino acid and thyroid hormone transporter Slc7a8
    Doreen Braun
    Institut für Experimentelle Endokrinologie, Charite Universitatsmedizin Berlin, Berlin, Germany
    Biochem J 439:249-55. 2011
    b>LAT2 (system L amino acid transporter 2) is composed of the subunits Slc7a8/Lat2 and Slc3a2/4F2hc...
  72. doi Psychosocial consequences and severity of disclosed incidental findings from whole-body MRI in a general population study
    Carsten Oliver Schmidt
    Study of Health in Pomerania KEF, University Medicine of Greifswald, Institute for Community Medicine, Walther Rathenau Str 48, 17475 Greifswald, Germany
    Eur Radiol 23:1343-51. 2013
    Little is known about the psychosocial impact and subjective interpretation of communicated incide ntal findings from whole-body magnetic resonance imaging (wb-MRI). This was addressed with this general population study.
  73. doi Transport of gabapentin by LAT1 (SLC7A5)
    David Dickens
    Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK
    Biochem Pharmacol 85:1672-83. 2013
    ..Gabapentin was negative for OCT like transport and LAT2 activity in the hCMEC/D3 and OCT1 transfected cells...
  74. pmc The AML1/ETO target gene LAT2 interferes with differentiation of normal hematopoietic precursor cells
    Aitomi Essig
    Department of Hematology and Oncology, University of Freiburg, Medical Center, Freiburg, Germany Electronic address
    Leuk Res 38:340-5. 2014
    The adaptor protein linker activator of T-cells 2 (LAT2) is a known AML1/ETO target gene whose function during normal hematopoiesis is unknown...
  75. pmc Structural bases for the interaction and stabilization of the human amino acid transporter LAT2 with its ancillary protein 4F2hc
    Albert Rosell
    Institute for Research in Biomedicine IRB Barcelona, E 08028 Barcelona, Spain
    Proc Natl Acad Sci U S A 111:2966-71. 2014
    ..electron microscopy and single-particle analysis of purified human 4F2hc/L-type amino acid transporter 2 (LAT2) heterodimers overexpressed in the yeast Pichia pastoris, together with docking analysis and crosslinking ..
  76. pmc Cerebral cortex hyperthyroidism of newborn mct8-deficient mice transiently suppressed by lat2 inactivation
    Bárbara Núñez
    Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Cientificas CSIC and Universidad Autonoma de Madrid UAM, Madrid, Spain
    PLoS ONE 9:e96915. 2014
    ..We have analyzed the role of the heterodimeric aminoacid transporter Lat2 (Slc7a8), in the presence or absence of Mct8, on thyroid hormone concentrations and on expression of thyroid ..
  77. doi Amino acid ester prodrugs conjugated to the α-carboxylic acid group do not display affinity for the L-type amino acid transporter 1 (LAT1)
    Jarkko Rautio
    School of Pharmacy, University of Eastern Finland, P O Box 1627, FI 70211 Kuopio, Finland Electronic address
    Eur J Pharm Sci 66:36-40. 2015
    ..1 showed no affinity for LAT1 in either model nor did it show any affinity for LAT2 in an in vitro study. Our results confirm the earlier reported requirements for LAT1 substrates...
  78. pmc Characterization of novel markers of senescence and their prognostic potential in cancer
    M Althubiti
    1 Department of Biochemistry, University of Leicester, Leicester, UK 2 Department of Biochemistry, Faculty of Medicine, Umm Al Qura University, Mecca, Saudi Arabia
    Cell Death Dis 5:e1528. 2014
    ..We identified 107 proteins that could be potential markers of senescence and validated 10 of them (DEP1, NTAL, EBP50, STX4, VAMP3, ARMX3, B2MG, LANCL1, VPS26A and PLD3)...
  79. pmc Tespa1 negatively regulates FcεRI-mediated signaling and the mast cell-mediated allergic response
    Di Wang
    Institute of Immunology, Program in Molecular and Cellular Biology, Department of Pathology and Pathophysiology, and Department of Biochemistry and Molecular Biology, Zhejiang University School of Medicine, Hangzhou 310058, China Institute of Immunology, Program in Molecular and Cellular Biology, Department of Pathology and Pathophysiology, and Department of Biochemistry and Molecular Biology, Zhejiang University School of Medicine, Hangzhou 310058, China
    J Exp Med 211:2635-49. 2014
    ..signaling within the LAT1 (linker for activation of T cells family, member 1) signalosome versus the LAT2 signalosome...
  80. ncbi Impairment of glutamine/glutamate-γ-aminobutyric acid cycle in manganese toxicity in the central nervous system
    M Sidoryk-Węgrzynowicz
    Marta Sidoryk Wegrzynowicz, PhD, Department of Clinical Neurosciences, The Clifford Allbutt Building CAB, University of Cambridge, Hills Road, Cambridge CB2 0QH, UK, E mail
    Folia Neuropathol 52:377-82. 2014
    ..Manganese added directly to astrocytes induces deregulation in the expression of SNAT3, SNAT2, ASCT2 and LAT2 transporters and significantly decreases in Gln uptake mediated by the transporting Systems N and ASC, and a ..
  81. pmc Microarray Determination of the Expression of Drug Transporters in Humans and Animal Species Used for the Investigation of Nasal Absorption
    Manar Al-Ghabeish
    Division of Pharmaceutics and Translational Therapeutics, University of Iowa, Iowa City, Iowa 52242, United States
    Mol Pharm 12:2742-54. 2015
    ..Several transporters were highly expressed in all the species, including MRP1, OCTN2, PEPT2, and y+LAT2. While some differences in transporter mRNA and protein expression were observed, the transporter expression ..
  82. doi Transport of Iodothyronines by Human L-Type Amino Acid Transporters
    Chantal Zevenbergen
    Department of Internal Medicine and Rotterdam Thyroid Center C Z, M E M, E C L d S, R P P, W E V, T J V, Erasmus University Medical Center, 3015 CN, Rotterdam, The Netherlands and Department of Nuclear Magnetic Resonance Supported Structural Biology A K, G K, Leibniz Institut fur Molekulare Pharmakologie, 13125 Berlin, Germany
    Endocrinology 156:4345-55. 2015
    ..The L-type amino acid transporters LAT1 and LAT2 are known to facilitate TH transport. However, the role of LAT3, LAT4, and LAT5 is still unclear...
  83. doi Induction of inducible nitric oxide synthase expression in ammonia-exposed cultured astrocytes is coupled to increased arginine transport by upregulated y(+)LAT2 transporter
    Magdalena Zielinska
    Department of Neurotoxicology, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
    J Neurochem 135:1272-81. 2015
    ..astrocytes specifically via y(+)L amino acid transport system, by activation of its member, a heteromeric y(+)LAT2 transporter...
  84. pmc Overexpression of L-Type Amino Acid Transporter 1 (LAT1) and 2 (LAT2): Novel Markers of Neuroendocrine Tumors
    Susi Barollo
    Endocrinology Unit, Department of Medicine, University Hospital of Padua, Padua, Italy
    PLoS ONE 11:e0156044. 2016
    ..18F-FDOPA is a large neutral amino acid biochemically resembling endogenous L-DOPA and taken up by the L-type amino acid transporters (LAT1 and LAT2). This study was conducted to examine the expression of the LAT system in PHEO and MTC.
  85. doi Don't trust an(t)ybody - Pitfalls during investigation of candidate proteins for methylmercury transport at the placental interface
    Isabella Ellinger
    Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria Electronic address
    Placenta 43:13-6. 2016
    ..of commercial antibodies against four candidate transporters (Large neutral amino acids transporter (LAT)1, LAT2, 4F2 cell-surface antigen heavy chain (4F2hc), and multidrug resistance-associated protein (MRP)2) by ..
  86. doi Evaluation of the mRNA and Protein Expressions of Nutritional Biomarkers in the Gastrointestinal Mucosa of Patients with Small Intestinal Disorders
    Masanao Nakamura
    Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Japan
    Intern Med 55:2145-52. 2016
    ..The mRNA expression of specific biomarkers (SGLT1, SGLT5, GIP, GLP, LAT1, LAT2, and NPC1L1) in the mucosa was compared among three patient groups: Inflammation, Tumor, and Control...
  87. pmc Down-Regulation of Placental Transport of Amino Acids Precedes the Development of Intrauterine Growth Restriction in Maternal Nutrient Restricted Baboons
    Priyadarshini Pantham
    Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado
    Biol Reprod 95:98. 2016
    ..MVM amino acid transporter isoform expression (SNAT1, SNAT2, and SNAT4 and LAT1 and LAT2) was measured using Western blots. LAT1 and LAT2 expression were also determined in BM...
  88. doi Gastrointestinal methionine shuttle: Priority handling of precious goods
    Lucia Mastrototaro
    Institute of Veterinary Physiology, Department of Veterinary Medicine, Free University of Berlin, Berlin, Germany
    IUBMB Life 68:924-934. 2016
    ..LAT4 is defective, basolateral Met exit may be compensated to a certain degree by the Met exchange proteins 4F2hc/LAT2 or 4F2hc/LAT1; while carriers 4F2hc/y+ LAT1, 4F2hc/y+ LAT2, SNAT1 and SNAT2, may serve ..
  89. doi Dissecting thyroid hormone transport and metabolism in dendritic cells
    Nicolás Gigena
    N Gigena, Bioquímica Clínica, Centro de Investigaciones en Bioquímica Clínica e Inmunología CIBICI CONICET Facultad de Ciencias Químicas Universidad Nacional de Córdoba, Cordoba, Argentina
    J Endocrinol . 2017
    ..Besides, DCs express MCT10 and LAT2 TH transporters and these cells mainly transport T3 with a favored involvement of MCT10, since its inhibition ..
  90. pmc Limnanthes douglasii lysophosphatidic acid acyltransferases: immunological quantification, acyl selectivity and functional replacement of the Escherichia coli plsC gene
    Adrian P Brown
    Department of Biological Sciences, University of Durham, South Road, Durham DH1 3LE, UK
    Biochem J 364:795-805. 2002
    ..lysophosphatidic acid acyltransferase (LPAAT) enzymes from Limnanthes douglasii (meadowfoam), LAT1 and LAT2, using the predicted soluble portion of each protein as recombinant protein antigens...
  91. ncbi Functional cooperation of epithelial heteromeric amino acid transporters expressed in madin-darby canine kidney cells
    Christian Bauch
    Institute of Physiology and Institute of Anatomy, University of Zurich, Winterthurerstrasse 190, Switzerland
    J Biol Chem 278:1316-22. 2003
    The heteromeric amino acid transporters b(0,+)AT-rBAT (apical), y(+)LAT1-4F2hc, and possibly LAT2-4F2hc (basolateral) participate to the (re)absorption of cationic and neutral amino acids in the small intestine and kidney proximal tubule...
  92. ncbi Involvement of the system L amino acid transporter on uptake of S-nitroso-L-cysteine, an endogenous S-nitrosothiol, in PC12 cells
    Takanori Nemoto
    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, 263 8522, Chiba, Japan
    Eur J Pharmacol 458:17-24. 2003
    ..System L is composed of the 4F2 light chains (LAT1 or LAT2) and the heavy chain, and the transcripts of these components were detected in RNA from PC12 cells...
  93. ncbi Construction of recombinant pseudorabies viruses optimized for labeling and neurochemical characterization of neural circuitry
    Zsolt Boldogkoi
    Laboratory of Neuromorphology, Department of Anatomy, Semmelweis University, Budapest, Hungary
    Brain Res Mol Brain Res 109:105-18. 2002
    ..fluorescent protein) genes into the genomic loci containing the putative latency-associated transcript promoter (P(LAT2)), resulting in the disruption of the promoter function...
  94. ncbi Glutamine efflux from astrocytes is mediated by multiple pathways
    Joachim W Deitmer
    School of Biochemistry and Molecular Biology, Australian National University, Canberra, Australia
    J Neurochem 87:127-35. 2003
    ..the expression of glutamine transporter mRNAs in cultured astrocytes it appeared likely that glutamine efflux was mediated by SN1, LAT2, ASCT2 and an additional, yet unidentified, transporter that mediates about 40% of the basal efflux.
  95. ncbi Characterization of cationic amino acid transporters and expression of endothelial nitric oxide synthase in human placental microvascular endothelial cells
    J F Dye
    Leukocyte Biology, Division of Biomedical Sciences, Imperial College School of Medicine, London SW7 2AZ
    FASEB J 18:125-7. 2004
    ..RT-PCR amplification products for eNOS, CAT1, CAT2A, CAT2B, CAT4, 4F2hc (CD98), rBAT and the light chains y+LAT1, y+LAT2, and b0+T1 were detected in HPMEC, but not B0+...
  96. ncbi An amino acid transporter involved in gastric acid secretion
    Philipp Kirchhoff
    Institute of Physiology and Center for Integrative Human Physiology CIHP, University of Zurich, Winterthurerstr 190, 8057 Zurich, Switzerland
    Pflugers Arch 451:738-48. 2006
    ..in mouse stomach parietal cells the expression of the system L heteromeric amino acid transporter comprised of the LAT2-4F2hc dimer...
  97. doi Effect of amino acids supply in reduced crude protein diets on performance, efficiency of mammary uptake, and transporter gene expression in lactating sows
    R Manjarin
    Department of Animal Science, Michigan State University, East Lansing 48824, USA
    J Anim Sci 90:3088-100. 2012
    ..Transcript abundance of AA transporters b(0,+)AT (SLC7A9), y(+)LAT2 (SLC7A6), ATB(0,+) (SLC6A14), CAT-1 (SLC7A1), and CAT-2b (SLC7A2) and milk protein β-casein (CSN2) and LALBA (α-..
  98. pmc Linker for activation of T-cell family member2 (LAT2) a lipid raft adaptor protein for AKT signaling, is an early mediator of alkylphospholipid anti-leukemic activity
    Carolina H Thomé
    Instituto Nacional de Ciência e Tecnologia em Células Tronco e Terapia Celular, Fundação Hemocentro de Ribeirão Preto, 14051 140, Ribeirao Preto, SP, Brazil
    Mol Cell Proteomics 11:1898-912. 2012
    ..One, the linker for activation of T-cell family member 2 (LAT2), is an adaptor protein associated with lipid rafts in its palmitoylated form and is specifically expressed in B ..
  99. ncbi The involvement of L-type amino acid transporters in theanine transport
    Sachiko Yamamoto
    Department of Chemistry, Kyorin University School of Medicine, Tokyo, Japan
    Biosci Biotechnol Biochem 76:2230-5. 2012
    ..Additionally, in experiments using cells stably expressing two system L isoforms, LAT1 and LAT2, we found that the two isoforms mediated L-theanine transport to similar extents...
  100. doi Functional characterization and molecular expression of large neutral amino acid transporter (LAT1) in human prostate cancer cells
    Mitesh Patel
    Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri Kansas City, 2464 Charlotte Street, Kansas City, MO 64108, USA
    Int J Pharm 443:245-53. 2013
    ..RT-PCR analysis provided a product band at 658 and 840 bp, specific to LAT1 and LAT2, respectively...
  101. doi Cooperative immunoregulatory function of the transmembrane adaptor proteins SIT and LAX
    Börge Arndt
    Institutes of Molecular and Clinical Immunology, Otto von Guericke University Magdeburg, Magdeburg, Germany
    J Leukoc Biol 93:353-62. 2013
    ..However, more recent in vivo studies have demonstrated that with the exception of LAT, TRAPs, such as SIT, NTAL, and LAX, only minimally affect immune cell functions...

Research Grants7

  1. Development of a mouse model of obesity in pregnancy
    Thomas Jansson; Fiscal Year: 2009
    ..transporter isoforms 1 and 3, System A isoforms SNAT 1, 2 and 4 and L-system amino acid transporter isoforms LAT 1, LAT2 and 4F2hc...
  2. METHYLMERCURY TRANSPORT ACROSS CELL MEMBRANES
    Nazzareno Ballatori; Fiscal Year: 2005
    ..the mechanism by which the MeHg-L-cysteine complex is transported on the L-type amino acid transporters LAT1 and LAT2. II...
  3. Acetylcysteine: An Antidote for Methylmercury Poisoning
    TRACEY SIMMONS WILLIS; Fiscal Year: 2003
    ..Our recent work has shown that MeHg-L-cysteine is a substrate for the human amino acid transporters, LAT1 and LAT2, facilitating MeHg's rapid distribution in the body (Simmons-Willis et al. Biochem. Journal, in press)...
  4. Adaptor molecules in lymphocyte signaling
    Weiguo Zhang; Fiscal Year: 2007
    ..We named this gene, LAB (Linker for activation of B cells). Our preliminary data showed that LAB shares many characteristics with LAT...
  5. ESTROGEN BIOSYNTHESIS AND UTERINE LEIOMYOMATA
    Serdar Bulun; Fiscal Year: 2007
    ..We predict that these studies will establish the critical role of P450arom in uterine leiomyomata and lead to identification of novel therapeutic targets. ..
  6. MECHANISMS OF ESTROGEN BIOSYNTHESIS IN ENDOMETRIOSIS
    Serdar Bulun; Fiscal Year: 2008
    ..Investigation of local feedback mechanisms responsible for interactions between estrogen biosynthesis, tissue growth, and inflammation will lead to the rational design of novel drug treatments. ..
  7. Breast Cancer-Proximal Stroma Interaction & Aromatase
    Serdar E Bulun; Fiscal Year: 2010
    ..noncarrier controls. Proposed studies may lead to new pilot trials of treatment and prevention using p38/JNK inhibitors in BRCA1 mutation carriers. ..