LARS2

Summary

Gene Symbol: LARS2
Description: leucyl-tRNA synthetase 2, mitochondrial
Alias: HLASA, LEURS, PRLTS4, mtLeuRS, leucine tRNA ligase 2, mitochondrial, leucine tRNA ligase 2, mitocondrial, leucine translase
Species: human

Top Publications

  1. ncbi A novel gene containing LIM domains (LIMD1) is located within the common eliminated region 1 (C3CER1) in 3p21.3
    H Kiss
    Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden
    Hum Genet 105:552-9. 1999
  2. ncbi Expression and characterization of the human mitochondrial leucyl-tRNA synthetase
    J M Bullard
    Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599 3290, USA
    Biochim Biophys Acta 1490:245-58. 2000
  3. ncbi Evidence that the mitochondrial leucyl tRNA synthetase (LARS2) gene represents a novel type 2 diabetes susceptibility gene
    Leen M 't Hart
    Leiden University Medical Center, Department of Molecular Cell Biology, Wassenaarseweg 72, 2333 AL Leiden, Netherlands
    Diabetes 54:1892-5. 2005
  4. pmc Overexpressed mitochondrial leucyl-tRNA synthetase suppresses the A3243G mutation in the mitochondrial tRNA(Leu(UUR)) gene
    Hyejeong Park
    Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    RNA 14:2407-16. 2008
  5. pmc Peptides from aminoacyl-tRNA synthetases can cure the defects due to mutations in mt tRNA genes
    Silvia Francisci
    Department of Biology and Biotechnologies Charles Darwin, Pasteur Institute Cenci Bolognetti Foundation and Sapienza University of Rome, Piazzale A Moro 5, 00185 Rome, Italy
    Mitochondrion 11:919-23. 2011
  6. pmc Human mitochondrial leucyl-tRNA synthetase corrects mitochondrial dysfunctions due to the tRNALeu(UUR) A3243G mutation, associated with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like symptoms and diabetes
    Ronghua Li
    Division of Human Genetics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Mol Cell Biol 30:2147-54. 2010
  7. pmc How does poverty beget poverty?
    Linda S Pagani
    Ecole de Psychoéducation, Centre de Recherche de l Hôpital Sainte Justine, Universite de Montreal, Montreal, Quebec
    Paediatr Child Health 12:693-7. 2007
  8. ncbi Crystal structure of leucyl-tRNA synthetase from the archaeon Pyrococcus horikoshii reveals a novel editing domain orientation
    Ryuya Fukunaga
    Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Japan
    J Mol Biol 346:57-71. 2005
  9. pmc Isolated CP1 domain of Escherichia coli leucyl-tRNA synthetase is dependent on flanking hinge motifs for amino acid editing activity
    Aswini K Betha
    Department of Biology and Biochemistry, 369 Science and Research Building II, University of Houston, Houston, Texas 77204 5001, USA
    Biochemistry 46:6258-67. 2007
  10. pmc A single residue in leucyl-tRNA synthetase affecting amino acid specificity and tRNA aminoacylation
    Stanley W Lue
    Eugene F Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, USA
    Biochemistry 46:4466-72. 2007

Research Grants

  1. Mechanism of proofreading by class I aminoacyl-tRNA synthetases
    John J Perona; Fiscal Year: 2010
  2. Susan A Martinis; Fiscal Year: 2014
  3. Philip Jon Rosenthal; Fiscal Year: 2016

Detail Information

Publications170 found, 100 shown here

  1. ncbi A novel gene containing LIM domains (LIMD1) is located within the common eliminated region 1 (C3CER1) in 3p21.3
    H Kiss
    Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden
    Hum Genet 105:552-9. 1999
    ..The human C3CER1-located LIMD1 gene should therefore be further studied for its possible role in tumor suppression...
  2. ncbi Expression and characterization of the human mitochondrial leucyl-tRNA synthetase
    J M Bullard
    Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599 3290, USA
    Biochim Biophys Acta 1490:245-58. 2000
    A cDNA clone encoding the human mitochondrial leucyl-tRNA synthetase (mtLeuRS) has been identified from the EST databases...
  3. ncbi Evidence that the mitochondrial leucyl tRNA synthetase (LARS2) gene represents a novel type 2 diabetes susceptibility gene
    Leen M 't Hart
    Leiden University Medical Center, Department of Molecular Cell Biology, Wassenaarseweg 72, 2333 AL Leiden, Netherlands
    Diabetes 54:1892-5. 2005
    ..In this study, we have examined whether variants in the leucyl tRNA synthetase gene (LARS2), involved in aminoacylation of tRNA(Leu(UUR)), associate with type 2 diabetes...
  4. pmc Overexpressed mitochondrial leucyl-tRNA synthetase suppresses the A3243G mutation in the mitochondrial tRNA(Leu(UUR)) gene
    Hyejeong Park
    Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    RNA 14:2407-16. 2008
    ..This suppression of a tRNA gene mutation by increasing the steady-state levels of its cognate aminoacyl-tRNA synthetase is a model for potential therapies for human pathogenic tRNA mutations...
  5. pmc Peptides from aminoacyl-tRNA synthetases can cure the defects due to mutations in mt tRNA genes
    Silvia Francisci
    Department of Biology and Biotechnologies Charles Darwin, Pasteur Institute Cenci Bolognetti Foundation and Sapienza University of Rome, Piazzale A Moro 5, 00185 Rome, Italy
    Mitochondrion 11:919-23. 2011
    ..In this report we show that this effect cannot be ascribed to the catalytic activity per se and that isolated domains of aminoacyl-tRNA synthetases and even short peptides thereof have suppressing effects...
  6. pmc Human mitochondrial leucyl-tRNA synthetase corrects mitochondrial dysfunctions due to the tRNALeu(UUR) A3243G mutation, associated with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like symptoms and diabetes
    Ronghua Li
    Division of Human Genetics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Mol Cell Biol 30:2147-54. 2010
    ..mechanism of the A3243G mutation and whether the overexpression of human mitochondrial leucyl-tRNA synthetase (LARS2) in the cytoplasmic hybrid (cybrid) cells carrying the A3243G mutation corrects the mitochondrial dysfunctions...
  7. pmc How does poverty beget poverty?
    Linda S Pagani
    Ecole de Psychoéducation, Centre de Recherche de l Hôpital Sainte Justine, Universite de Montreal, Montreal, Quebec
    Paediatr Child Health 12:693-7. 2007
    ..Puisque leur rendement n'équivaut pas à celui de leurs camarades des classes moyennes, ces enfants sont plus vulnérables à l'échec scolaire et aux troubles de ..
  8. ncbi Crystal structure of leucyl-tRNA synthetase from the archaeon Pyrococcus horikoshii reveals a novel editing domain orientation
    Ryuya Fukunaga
    Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Japan
    J Mol Biol 346:57-71. 2005
    The editing domains of the closely homologous leucyl, isoleucyl, and valyl-tRNA synthetases (LeuRS, IleRS, and ValRS, respectively) contribute to accurate aminoacylation, by hydrolyzing misformed non-cognate aminoacyl-tRNAs...
  9. pmc Isolated CP1 domain of Escherichia coli leucyl-tRNA synthetase is dependent on flanking hinge motifs for amino acid editing activity
    Aswini K Betha
    Department of Biology and Biochemistry, 369 Science and Research Building II, University of Houston, Houston, Texas 77204 5001, USA
    Biochemistry 46:6258-67. 2007
    Protein synthesis and its fidelity rely upon the aminoacyl-tRNA synthetases. Leucyl-tRNA synthetase (LeuRS), isoleucyl-tRNA synthetase (IleRS), and valyl-tRNA synthetase (ValRS) have evolved a discrete editing domain called CP1 that ..
  10. pmc A single residue in leucyl-tRNA synthetase affecting amino acid specificity and tRNA aminoacylation
    Stanley W Lue
    Eugene F Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, USA
    Biochemistry 46:4466-72. 2007
    Human mitochondrial leucyl-tRNA synthetase (hs mt LeuRS) achieves high aminoacylation fidelity without a functional editing active site, representing a rare example of a class I aminoacyl-tRNA synthetase (aaRS) that does not proofread ..
  11. pmc A Flexible peptide tether controls accessibility of a unique C-terminal RNA-binding domain in leucyl-tRNA synthetases
    Jennifer L Hsu
    Department of Biochemistry, University of Illinois at Urbana Champaign, 419 Roger Adams Laboratory, Box B 4, 600 S Mathews Ave, Urbana, IL 61801 3732, USA
    J Mol Biol 376:482-91. 2008
    A unique C-terminal domain extension is required by most leucyl-tRNA synthetases (LeuRS) for aminoacylation. In one exception, the enzymatic activity of yeast mitochondrial LeuRS is actually impeded by its own C-terminal domain...
  12. pmc Cross-species aminoacylation of tRNA with a long variable arm between Escherichia coli and Saccharomyces cerevisiae
    A Soma
    Department of Biology, Faculty of Science, Hirosaki University, Hirosaki 036 8561, Japan Biochemistry and Biotechnology, Faculty of
    Nucleic Acids Res 26:4374-81. 1998
    ..Both SerRS and LeuRS from E...
  13. ncbi Functional association between three archaeal aminoacyl-tRNA synthetases
    Mette Praetorius-Ibba
    Department of Microbiology, The Ohio State University, Columbus, Ohio 43210 1292, USA
    J Biol Chem 282:3680-7. 2007
    ..aaRSs have also been reported in archaea, including a complex between prolyl-(ProRS) and leucyl-tRNA synthetases (LeuRS) in Methanothermobacter thermautotrophicus that enhances tRNA(Pro) aminoacylation...
  14. ncbi Mutational analysis of the antagonist-binding site of the histamine H(1) receptor
    K Wieland
    Leiden Amsterdam Center for Drug Research, Department of Pharmacochemistry, Division of Medicinal Chemistry, Faculty of Chemistry, Vrije Universiteit, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands
    J Biol Chem 274:29994-30000. 1999
    ..M., Timmerman, H., Leurs, H., Nederkoorn, P. H. J., Smit, M. J., and Donne-Op den Kelder, G. M. (1995) J. Comp. Aid. Mol. Design...
  15. pmc An aminoacyl-tRNA synthetase:elongation factor complex for substrate channeling in archaeal translation
    Corinne D Hausmann
    Department of Microbiology, Ohio State Biochemistry Program, and Ohio State RNA Group, The Ohio State University, Columbus, Ohio 43210 1292, USA
    Nucleic Acids Res 35:6094-102. 2007
    ..EF-1alpha was found to form a stable complex with leucyl-tRNA synthetase (LeuRS; K(D) = 0.7 microM)...
  16. pmc An inserted region of leucyl-tRNA synthetase plays a critical role in group I intron splicing
    Seung Bae Rho
    Department of Biology and Biochemistry, University of Houston, Houston, TX 77204 5001, USA
    EMBO J 21:6874-81. 2002
    Yeast mitochondrial leucyl-tRNA synthetase (LeuRS) binds to the bI4 intron and collaborates with the bI4 maturase to aid excision of the group I intron...
  17. pmc Association between Archaeal prolyl- and leucyl-tRNA synthetases enhances tRNA(Pro) aminoacylation
    Mette Praetorius-Ibba
    Department of Microbiology, The Ohio State University, Columbus, Ohio 43210 1292, USA
    J Biol Chem 280:26099-104. 2005
    ..proteins identified included components of methanogenesis, protein-modifying factors, and leucyl-tRNA synthetase (LeuRS)...
  18. doi A unique insertion in the CP1 domain of Giardia lamblia leucyl-tRNA synthetase
    Xiao Long Zhou
    State Key Laboratory of Molecular Biology, Graduate School of the Chinese Academy of Sciences, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, The Chinese Academy of Sciences, People s Republic of China
    Biochemistry 48:1340-7. 2009
    Leucyl-tRNA synthetase (LeuRS) catalyzes the esterification of the tRNA(Leu) isoacceptor with leucine. It contains a large insertion domain, connective peptide 1 (CP1), for amino acid editing...
  19. pmc Dynamical networks in tRNA:protein complexes
    Anurag Sethi
    Department of Chemistry, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 106:6620-5. 2009
    ..pathways in a bacterial glutamyl-tRNA synthetase (GluRS):tRNA(Glu) and an archaeal leucyl-tRNA synthetase (LeuRS):tRNA(Leu) complex...
  20. doi Roughness analysis of the skin as a secondary evaluation criterion in addition to visual scoring is sufficient to evaluate ethnic differences in wrinkles
    T Fujimura
    Biological Science Laboratories, Kao Corporation, Ichikai machi, Haga gun, Tochigi 321 3497, Japan
    Int J Cosmet Sci 31:361-7. 2009
    ..We conclude that roughness analysis of the skin is an important secondary evaluation criterion to visual scoring necessary to evaluate ethnic differences of wrinkles...
  21. pmc Recognition of tRNALeu by Aquifex aeolicus leucyl-tRNA synthetase during the aminoacylation and editing steps
    Peng Yao
    State Key Laboratory of Molecular Biology Graduate School of the Chinese Academy of Sciences, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, The Chinese Academy of Sciences, Shanghai, People s Republic of China
    Nucleic Acids Res 36:2728-38. 2008
    ..tRNA(Leu) recognition sets and their evolution, the recognition of tRNA(Leu) by the leucyl-tRNA synthetase (LeuRS) from the primitive hyperthermophilic bacterium Aquifex aeolicus was studied by RNA probing and mutagenesis...
  22. doi [Neuroplasticity: from physiological adaptation to the concept of therapeutic plasticity]
    Brigitte Onteniente
    INSERM, UMR 894, Centre de Recherches en Psychiatrie et Neurosciences, 2ter rue d Alesia, 75014 Paris, France
    J Soc Biol 203:107-11. 2009
    ....
  23. pmc Molecular cloning and nucleotide sequence of the gene for Escherichia coli leucyl-tRNA synthetase
    M Hartlein
    European Molecular Biology Laboratory, Grenoble, France
    Nucleic Acids Res 15:10199-210. 1987
    ..coli gene bank DNA. The resulting clones overexpress leucyl-tRNA synthetase (LeuRS) by a factor greater than 50. The DNA sequence of the complete coding regions was determined...
  24. pmc Structural and functional mapping of the archaeal multi-aminoacyl-tRNA synthetase complex
    Corinne D Hausmann
    Department of Microbiology, The Ohio State University, 484 West 12th Avenue, Columbus, OH 43210 1292, USA
    FEBS Lett 582:2178-82. 2008
    Methanothermobacter thermautotrophicus contains a multi-aminoacyl-tRNA synthetase complex (MSC) of LysRS, LeuRS and ProRS. Elongation factor (EF) 1A also associates to the MSC, with LeuRS possibly acting as a core protein...
  25. ncbi [In Process Citation]
    Mathieu Molimard
    , CHU de Bordeaux, Bordeaux, France
    Therapie 64:203-7. 2009
    ..b>Leurs données sont utilisées notamment lors d'une réévaluation anticipée ou lors du renouvellement d'..
  26. doi Functional characterization of leucine-specific domain 1 from eukaryal and archaeal leucyl-tRNA synthetases
    Xiao Long Zhou
    Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, People s Republic of China
    Biochem J 429:505-13. 2010
    b>LeuRS (leucyl-tRNA synthetase) catalyses the esterification of tRNAsLeu with leucine...
  27. pmc Modular pathways for editing non-cognate amino acids by human cytoplasmic leucyl-tRNA synthetase
    Xin Chen
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, The Chinese Academy of Sciences, Shanghai 200031, China
    Nucleic Acids Res 39:235-47. 2011
    ..Class Ia leucyl-tRNA synthetase (LeuRS) may misactivate various natural and non-protein amino acids and then mischarge tRNA(Leu)...
  28. pmc tRNA-dependent pre-transfer editing by prokaryotic leucyl-tRNA synthetase
    Min Tan
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, The Chinese Academy of Sciences, Shanghai 200031, China
    J Biol Chem 285:3235-44. 2010
    ..In this work we studied the different editing pathways of class Ia leucyl-tRNA synthetase (LeuRS)...
  29. ncbi Human/mouse microcell hybrid based elimination test reduces the putative tumor suppressor region at 3p21.3 to 1.6 cM
    A Szeles
    Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden
    Genes Chromosomes Cancer 20:329-36. 1997
    ..We have defined a common eliminated region of approximately 1.6 cM (designated as CER1) inside the 7 cM CER described earlier. CER1 is flanked distally by D3S1029 and proximally by D3S643...
  30. ncbi A Strong Promoter Provided with the Gene Encoding Arginyl-tRNA Synthetase(argS) from Escherichia coli
    Mo Fang Liu
    State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry, The Chinese Academy of Sciences, Shanghai 200031, China
    Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 32:435-440. 2000
    ..coli transformant TG1/pUC-argS, while the gene leuS, encoding the leucyl-tRNA synthetase(LeuRS) from E.coli, was only overproduced 35-fold in the same case...
  31. ncbi High-level expression and single-step purification of leucyl-tRNA synthetase from Aquifex aeolicus
    Chen Ling
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, The Chinese Academy of Sciences, 320 Yue Yang Road, 200031, PR China
    Protein Expr Purif 36:146-9. 2004
    Aquifex aeolicus leucyl-tRNA synthetase is the only known heterodimeric LeuRS, consisting of two subunits with molecular masses of 74.0 and 33.5 kDa, and named alphabeta-LeuRS...
  32. ncbi Aminoacylation complex structures of leucyl-tRNA synthetase and tRNALeu reveal two modes of discriminator-base recognition
    Ryuya Fukunaga
    Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Tokyo, Japan
    Nat Struct Mol Biol 12:915-22. 2005
    Leucyl-tRNA synthetase (LeuRS) specifically recognizes the characteristic long variable arm and the discriminator base, A73, of tRNA(Leu) in archaea and eukarya. The LeuRS 'editing domain' hydrolyzes misformed noncognate aminoacyl-tRNA...
  33. ncbi Split leucine-specific domain of leucyl-tRNA synthetase from the hyperthermophilic bacterium Aquifex aeolicus
    Jing Jing Ma
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Graduate School of the Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, People s Republic of China
    Biochemistry 45:14809-16. 2006
    Leucyl-tRNA synthetase (LeuRS) from Aquifex aeolicus is the only known heterodimer synthetase. It is named LeuRS alphabeta;, and its alpha and beta subunits contain 634 and 289 residues, respectively...
  34. doi Unique residues crucial for optimal editing in yeast cytoplasmic Leucyl-tRNA synthetase are revealed by using a novel knockout yeast strain
    Peng Yao
    State Key Laboratory of Molecular Biology, Graduate School of the Chinese Academy of Sciences, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, The Chinese Academy of Sciences, Shanghai, China
    J Biol Chem 283:22591-600. 2008
    Leucyl-tRNA synthetase (LeuRS) contains an editing domain that discriminates leucine from noncognate amino acids to ensure translational fidelity...
  35. pmc The CP2 domain of leucyl-tRNA synthetase is crucial for amino acid activation and post-transfer editing
    Xiao Long Zhou
    State Key Laboratory of Molecular Biology and Graduate School of the Chinese Academy of Sciences, Institute of Biochemistry and Cell Biology, The Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
    J Biol Chem 283:36608-16. 2008
    Leucyl-tRNA synthetase (LeuRS) has an insertion domain, called connective peptide 2 (CP2), either directly preceding or following the editing domain (CP1 domain), depending on the species...
  36. doi Interdomain communication modulates the tRNA-dependent pre-transfer editing of leucyl-tRNA synthetase
    Min Tan
    State Key Laboratory of Molecular Biology, Center for RNA Research, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
    Biochem J 449:123-31. 2013
    EcLeuRS [Escherichia coli LeuRS (leucyl-tRNA synthetase)] has evolved both tRNA-dependent pre- and post-transfer editing capabilities to ensure catalytic specificity...
  37. pmc Mutations in LARS2, encoding mitochondrial leucyl-tRNA synthetase, lead to premature ovarian failure and hearing loss in Perrault syndrome
    Sarah B Pierce
    Division of Medical Genetics, Department of Medicine, University of Washington, Seattle WA 98195, USA
    Am J Hum Genet 92:614-20. 2013
    ..by hearing loss (together, these symptoms compose Perrault syndrome), exome sequencing revealed mutations in LARS2, encoding mitochondrial leucyl-tRNA synthetase: homozygous c.1565C>A (p...
  38. pmc The Yin and Yang of tRNA: proper binding of acceptor end determines the catalytic balance of editing and aminoacylation
    Min Tan
    Center for RNA Research, State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, The Chinese Academy of Sciences, Shanghai 200031, PR China
    Nucleic Acids Res 41:5513-23. 2013
    ..The fidelity of leucyl-tRNA synthetase (LeuRS) depends mainly on proofreading at the pre- and post-transfer levels...
  39. doi Discovery of N-(4-sulfamoylphenyl)thioureas as Trypanosoma brucei leucyl-tRNA synthetase inhibitors
    Fenglong Zhang
    School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China
    Org Biomol Chem 11:5310-24. 2013
    ..There is an urgent need for new therapeutics, especially those in new chemical classes. Leucyl-tRNA synthetase (LeuRS) has been paid much attention as a recently clinically validated antimicrobial target...
  40. pmc Human mitochondrial leucyl tRNA synthetase can suppress non cognate pathogenic mt-tRNA mutations
    Hue Tran Hornig-Do
    The Wellcome Trust Centre for Mitochondrial Research Institute for Ageing and Health The Medical School, Newcastle University, Newcastle upon Tyne, UK
    EMBO Mol Med 6:183-93. 2014
    ..These data support the possibility that a small peptide could correct at least the biochemical defect associated with many mt-tRNA mutations, inferring a novel therapy for these disorders. ..
  41. pmc Coexistence of bacterial leucyl-tRNA synthetases with archaeal tRNA binding domains that distinguish tRNA(Leu) in the archaeal mode
    Zhi Peng Fang
    Center for RNA Research, State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, The Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
    Nucleic Acids Res 42:5109-24. 2014
    Leucyl-tRNA (transfer RNA) synthetase (LeuRS) is a multi-domain enzyme, which is divided into bacterial and archaeal/eukaryotic types...
  42. ncbi Elements pour l'elaboration et la mise en place d'un programme de promotion de la sante cardiovasculaire en Communaute francaise de Belgique
    Yves Coppieters
    Centre d Education du Patient ASBL, Rue Fond de la Biche 4, 5530 Godinne, Belgique
    Glob Health Promot 18:37-46. 2011
    ..proximité, la mobilisation des responsables politiques et institutionnels et le soutien des professionnels dans leurs actions envers les patients et la population...
  43. ncbi [Solutions for the better integration of public health ethical considerations]
    Michel Désy
    Institut National de Sante Publique du Quebec
    Can J Public Health 105:e142-5. 2014
    ....
  44. pmc The physiological target for LeuRS translational quality control is norvaline
    Nevena Cvetesic
    Department of Chemistry, Faculty of Science University of Zagreb, Zagreb, Croatia
    EMBO J 33:1639-53. 2014
    ..Rather, as shown by kinetic, structural and in vivo approaches, the prime biological function of LeuRS editing is to prevent mis-incorporation of the non-standard amino acid norvaline...
  45. pmc A bridge between the aminoacylation and editing domains of leucyl-tRNA synthetase is crucial for its synthetic activity
    Qian Huang
    Center for RNA Research, State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, The Chinese Academy of Sciences, Shanghai 200031, China
    RNA 20:1440-50. 2014
    Leucyl-tRNA synthetases (LeuRSs) catalyze the linkage of leucine with tRNA(Leu). LeuRS contains a catalysis domain (aminoacylation) and a CP1 domain (editing). CP1 is inserted 35 Å from the aminoacylation domain...
  46. pmc Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment of complicated urinary tract infections
    Karen O'Dwyer
    Antibacterial Discovery Performance Unit, GlaxoSmithKline R and D, Collegeville, Pennsylvania, USA
    Antimicrob Agents Chemother 59:289-98. 2015
    GSK2251052, a novel leucyl-tRNA synthetase (LeuRS) inhibitor, was in development for the treatment of infections caused by multidrug-resistant Gram-negative pathogens...
  47. ncbi Mutuelles de santé en Afrique : caractéristiques et relations contractuelles avec les prestataires de soins pour la prise en charge de la qualité des soins
    Pascal Ndiaye
    Santé Publique, Institut de médecine tropicale Prince Léopold, Anvers, Belgique Financement de la santé, AEDES, Bruxelles, Belgique
    Glob Health Promot . 2015
    ..Les mutuelles de santé (MS) sont mises en place pour réduire la barrière financière et assurer à leurs membres un accès à des soins de qualité...
  48. doi The Enduring Influence of Parent's Voluntary Involvement on Their Children's Volunteering in Later Life
    Thomas A Perks
    University of Lethbridge
    Can Rev Sociol 52:89-101. 2015
    ..The implications of these findings for volunteering in Canada are discussed...
  49. pmc Modulation of Aminoacylation and Editing Properties of Leucyl-tRNA Synthetase by a Conserved Structural Module
    Wei Yan
    From The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
    J Biol Chem 290:12256-67. 2015
    ..Mutation of highly conserved basic residues on the third α-helix of this domain impairs the affinity of LeuRS for the anticodon stem of tRNA(Leu), which decreases both aminoacylation and editing activities...
  50. doi Political pugilists: recuperative gender strategies in canadian electoral politics
    Elise Maiolino
    University of Toronto
    Can Rev Sociol 52:115-33. 2015
    ..de récupération des sexes pour décrire et expliquer comment des dirigeants politiques travaillent à rétablir leurs identités sexuelles publiques...
  51. doi Exposé sur les conséquences éthiques des tests aléatoires de dépistage des drogues en milieu de travail
    Timothy Christie
    Département de bioéthique, Faculte de Medecine, Université Dalhousie, Halifax Nouvelle Écosse Canada Services éthiques, Réseau de santé Horizon, Miramichi Nouveau Brunswick Canada
    Healthc Manage Forum 28:175-8. 2015
    ..Les employeurs doivent s'assurer que chaque aspect de leurs politiques repose sur des données scientifiques, est lié rationnellement à l'objectif de la sécurité en ..
  52. doi Economic Benefits of Self-Employment for Canadian Immigrants
    Reza Nakhaie
    University of Windsor
    Can Rev Sociol 52:377-401. 2015
    ..I also show that the economic benefits of self-employment depend on the ethno-racial groups and the industrial mix of their self-employment...
  53. ncbi Not Too Old, Not Too Young: Older Women's Perceptions of Physicians
    Hazel Macrae
    Mount Saint Vincent University, Nova Scotia
    Can J Aging 34:545-560. 2015
    ..plus souvent que les hommes âgés et les personnes plus jeunes; pourtant, la connaissance et la compréhension de leurs expériences avec les médecins sont limitées...
  54. pmc First independent replication of the involvement of LARS2 in Perrault syndrome by whole-exome sequencing of an Italian family
    Giulia Soldà
    Department of Biomedical Sciences, Humanitas University, Milan, Italy
    J Hum Genet 61:295-300. 2016
    ..Recently, mutations in five genes (HSD17B4, HARS2, CLPP, LARS2 and C10ORF2) were found to be responsible for Perrault syndrome, although they do not account for all cases of ..
  55. doi Discovery of potent anti-tuberculosis agents targeting leucyl-tRNA synthetase
    Olga I Gudzera
    Institute of Molecular Biology and Genetics, NAS of Ukraine, 150 Zabolotnogo St, 03680 Kyiv, Ukraine
    Bioorg Med Chem 24:1023-31. 2016
    ..Leucyl-tRNA synthetase (LeuRS) has been recently clinically validated as antimicrobial target...
  56. doi P3-26: Prevalence of true resistant hypertension among uncontrolled hypertensive patients referred to a tertiary health care center
    N Henine
    CHU de Tizi Ouzou, Cardiologie, Tizi Ouzou, Algerie
    Ann Cardiol Angeiol (Paris) 64:S31-2. 2015
    ..vraie » et étaient éligibles à une intensification du traitement antihypertenseur (4 molécules ou plus) ; leurs caractéristiques cliniques étaient : diabète (27.2 %) ; tabagisme (39.3 %) ; BMI moyen à 30.6±4...
  57. doi P-180: The dry weight of the ceaseless quest for chronic he modialysis in controlling blood pressure, what strategy adopted?
    L Azouaou
    Chu Parnet Nefissa Hamoud H Dey, Alger, Algerie
    Ann Cardiol Angeiol (Paris) 64:S83. 2015
    ..Nous avons corrigé le poids sec des patients selon le poids déterminé par les 3 méthodes et au bout de 2 mois on a noté une équilibration de l'état d'hydratation des patients ainsi que leurs pressions artérielles.
  58. doi P-189: Determination of oxidant/antioxidant status in hypertensive patients with chronic renal failure
    S Bouanane
    Service de cardiologie, CHU de Tlemcen, Tlemcen, Algerie
    Ann Cardiol Angeiol (Paris) 64:S86-7. 2015
    ..comme un déséquilibre prononcé entre les éléments antioxydants et oxydants en faveur de ces derniers et de leurs effets potentiellement néfastes...
  59. doi [Not Available]
    Chantal Lavergne
    Can J Public Health 106:eS38-44. 2016
    ..The article describes the positive outcomes of this initiative for the women, based on the experiences and perception of the participants and social workers involved...
  60. pmc A Novel Missense Mutation in the CLPP Gene Causing Perrault Syndrome Type 3 in a Turkish Family
    Fatma Dursun
    Umraniye Training and Research Hospital, Clinic of Pediatric Endocrinology, Istanbul, Turkey, Phone 90 216 632 18 18 E mail
    J Clin Res Pediatr Endocrinol 8:472-477. 2016
    ..Mutations in five genes, i.e. HSD17B4, HARS2, CLPP, LARS2, and C10orf2, have been reported in five subtypes of PRLTS...
  61. ncbi Identification of Mycobacterium tuberculosis leucyl-tRNA synthetase (LeuRS) inhibitors among the derivatives of 5-phenylamino-2H-[1,2,4]triazin-3-one
    Olga I Gudzera
    a Institute of Molecular Biology and Genetics, NAS of Ukraine, Kyiv, Ukraine and
    J Enzyme Inhib Med Chem 31:201-207. 2016
    ..We have identified inhibitors of M. tuberculosis leucyl-tRNA synthetase (LeuRS) among the derivatives of 5-phenylamino-2H-[1,2,4]triazin-3-one...
  62. pmc Cryptosporidium and Toxoplasma Parasites Are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase
    Andres Palencia
    European Molecular Biology Laboratory, Grenoble Outstation, Grenoble, France, and University Grenoble Alpes CNRS EMBL International Unit UMI 3265 for Virus Host Cell Interactions, UMI 3265, Grenoble, France Institute for Advanced Biosciences, Team Host Pathogen Interactions and Immunity to Infection, INSERM U1209, CNRS UMR5309, Université Grenoble Alpes, Grenoble, France
    Antimicrob Agents Chemother 60:5817-27. 2016
    ..of affinity and crystal structures of complexes with the editing domain of Cryptosporidium leucyl-tRNA synthetase (LeuRS)...
  63. pmc Structural characterization of antibiotic self-immunity tRNA synthetase in plant tumour biocontrol agent
    Shaileja Chopra
    Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7090, USA
    Nat Commun 7:12928. 2016
    ..We previously showed that TM84 employs a unique tRNA-dependent mechanism to inhibit leucyl-tRNA synthetase (LeuRS), while the TM84-producer prevents self-poisoning by expressing a resistant LeuRS AgnB2...
  64. ncbi Leucyl-tRNA synthetase consisting of two subunits from hyperthermophilic bacteria Aquifex aeolicus
    Min Gang Xu
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China
    J Biol Chem 277:41590-6. 2002
    In a hyperthermophilic bacterium, Aquifex aeolicus, leucyl-tRNA synthetase (LeuRS) consists of two non-identical polypeptide subunits (alpha and beta), different from the canonical LeuRS, which has a single polypeptide chain...
  65. pmc RNA and protein requirements for incorporation of the Pol protein into foamy virus particles
    Katrin Peters
    Institut fur Virologie und Immunbiologie, Universitat Wurzburg, Versbacher Str 7, 97078 Wurzburg, Germany
    J Virol 79:7005-13. 2005
    ..We previously showed that the packaging of (pre)genomic RNA is essential for Pol encapsidation (M. Heinkelein, C. Leurs, M. Rammling, K. Peters, H. Hanenberg, and A. Rethwilm, J. Virol. 76:10069-10073, 2002)...
  66. ncbi Leucyl-tRNA synthetase from the extreme thermophile Aquifex aeolicus has a heterodimeric quaternary structure
    Masaki Gouda
    Department of Biomolecular Science, Faculty of Engineering, Gifu University, Yanagido 1 1, 501 1193, Gifu, Japan
    FEBS Lett 518:139-43. 2002
    ..genome sequence of a hyper thermophile Aquifex aeolicus suggests that the gene for leucyl-tRNA synthetases (LeuRS) is probably split into two pieces (leuS and leuS')...
  67. ncbi Towards a phosphoproteome map of Corynebacterium glutamicum
    Anne K Bendt
    Institut fur Biochemie, Universitat zu Koln, Zulpicher Strasse 47, D 50674 Köln, Germany
    Proteomics 3:1637-46. 2003
    ..Both detection techniques were used to create a phosphoproteome map. Additionally, the influence of nitrogen deprivation on the phosphoproteome of C. glutamicum was investigated...
  68. ncbi Leucyl-tRNA synthetase from the hyperthermophilic bacterium Aquifex aeolicus recognizes minihelices
    Min Gang Xu
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, The Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
    J Biol Chem 279:32151-8. 2004
    ..Although Escherichia coli or Homo sapiens cytoplasmic leucyl-tRNA synthetase (LeuRS) is unable to charge the cognate minihelix or microhelix, we show here that minihelix(Leu) is efficiently charged ..
  69. pmc Two distinct domains of the beta subunit of Aquifex aeolicus leucyl-tRNA synthetase are involved in tRNA binding as revealed by a three-hybrid selection
    Yong Gang Zheng
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China
    Nucleic Acids Res 32:3294-303. 2004
    The Aquifex aeolicus alphabeta-LeuRS is the only known heterodimeric class Ia aminoacyl-tRNA synthetase. In this study, we investigated the function of the beta subunit which is believed to bind tRNA(Leu)...
  70. pmc Leucyl-tRNA synthetase from the ancestral bacterium Aquifex aeolicus contains relics of synthetase evolution
    Ming Wei Zhao
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, The Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, PR China
    EMBO J 24:1430-9. 2005
    ..the isolated editing domain of leucyl-tRNA synthetase from the deep-rooted bacterium Aquifex aeolicus (alphabeta-LeuRS) catalyzes the hydrolytic editing of both mischarged tRNA(Leu) and minihelix(Leu)...
  71. ncbi Major biocontrol of plant tumors targets tRNA synthetase
    John S Reader
    Skaggs Institute for Chemical Biology, Scripps Research Institute, La Jolla, CA 92037, USA
    Science 309:1533. 2005
    ..We demonstrate that this biocontrol agent targets A. tumefaciens leucyl-tRNA synthetase (LeuRS), an essential enzyme for cell viability, while the agent itself survives by having a second, self-protective copy ..
  72. ncbi [Relations between maternal food practices and diet of preschool age Quebec children]
    Geneviève Dulude
    Universite de Montreal
    Can J Diet Pract Res 74:119-23. 2013
    ..The goal of this study is to examine the relationships between mothers' food practices and the diets of their preschool children...
  73. pmc Discovery of a novel class of boron-based antibacterials with activity against gram-negative bacteria
    Vincent Hernandez
    Anacor Pharmaceuticals Inc, Palo Alto, CA, USA
    Antimicrob Agents Chemother 57:1394-403. 2013
    ..We have previously identified a new a way to inhibit an aminoacyl-tRNA synthetase, leucyl-tRNA synthetase (LeuRS), in fungi via the oxaborole tRNA trapping (OBORT) mechanism...
  74. pmc Leucyl-tRNA synthetase editing domain functions as a molecular rheostat to control codon ambiguity in Mycoplasma pathogens
    Li Li
    Center for Biophysics and Computational Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 110:3817-22. 2013
    ..A high-resolution X-ray crystal structure shows that M. mobile LeuRS structurally overlaps with other LeuRS cores...
  75. pmc Leucine-specific domain modulates the aminoacylation and proofreading functional cycle of bacterial leucyl-tRNA synthetase
    Wei Yan
    State Key Laboratory of Molecular Biology, Center for RNA Research, Institute of Biochemistry and Cell Biology, The Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, PR China
    Nucleic Acids Res 41:4988-98. 2013
    ..However, the LeuRS from Mycoplasma mobile (MmLeuRS) has a tetrapeptide GKDG instead of the LSD...
  76. pmc Discovery of a potent benzoxaborole-based anti-pneumococcal agent targeting leucyl-tRNA synthetase
    Qing Hua Hu
    1 State Key Laboratory of Molecular Biology, Center for RNA Research, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, The Chinese Academy of Sciences, Shanghai 200031, China 2
    Sci Rep 3:2475. 2013
    ..The emergency of multidrug-resistant bacteria threatens the treatment of the disease. Leucyl-tRNA synthetase (LeuRS) plays an essential role in cellular translation and is an attractive drug target for antimicrobial development...
  77. ncbi Mechanism of the activation step of the aminoacylation reaction: a significant difference between class I and class II synthetases
    Sindrila Dutta Banik
    Department of Chemistry, University of Kalyani, Kalyani, Nadia, West Bengal, 741235, India
    J Biomol Struct Dyn 30:701-15. 2012
    ..The class I aaRSs investigated are GluRS, GlnRS, TyrRS, TrpRS, LeuRS, ValRS, IleRS, CysRS, and MetRS and class II aaRSs investigated are HisRS, LysRS, ProRS, AspRS, AsnRS, AlaRS, ..
  78. pmc [Primitive peritonitis: real entity but difficult to diagnose]
    Rajae Yamou
    Service des urgences chirurgicales viscérales, Hopital Ibn Sina, Rabat, Maroc
    Pan Afr Med J 12:83. 2012
    ..Elles simulent les péritonites secondaires. C'est pourquoi leur diagnostic ne peut être que peropératoire. Nous rapportons deux cas de péritonites primitives dans le but de discuter leurs aspects diagnostique et thérapeutiques.
  79. doi 3,5-Dicaffeoylquinic acid isolated from Artemisia argyi and its ester derivatives exert anti-leucyl-tRNA synthetase of Giardia lamblia (GlLeuRS) and potential anti-giardial effects
    Yan Hong Zhang
    Shanghai Key Laboratory of Functional Materials Chemistry, and Research Center of Analysis and Test, East China University of Science and Technology, Shanghai 200237, PR China
    Fitoterapia 83:1281-5. 2012
    An aqueous ethanol extract of Artemisia argyi inhibited the aminoacylation activity of LeuRS from Giardia lamblia (GlLeuRS)...
  80. pmc [[Study of factors related to adherence to antiretroviral therapy among patients followed at HIV/AIDS Unit in the District Hospital of Dschang, Cameroon]]
    Francois Xavier Mbopi-Keou
    Laboratoire National de Santé Hygiène Mobile, Ministere de la Sante Publique, Yaounde, Cameroun et Faculté de Médecine et des Sciences Biomédicales, Universite de Yaounde I, Yaounde, Cameroun
    Pan Afr Med J 12:55. 2012
    ..a été évaluée sur la base des déclarations des patients et sur la régularité du renouvellement de leurs ordonnances (observance calculée)...
  81. ncbi Partition of tRNA synthetases into two classes based on mutually exclusive sets of sequence motifs
    G Eriani
    Laboratoires de Biochimie, IBMC du CNRS, Strasbourg, France
    Nature 347:203-6. 1990
    ..of the 18 known aaRS, only 9 referred to as class I synthetases (GlnRS, TyrRS, MetRS, GluRS, ArgRS, ValRS, IleRS, LeuRS, TrpRS), display two short common consensus sequences ('HIGH' and 'KMSKS') which indicate, as observed in three ..
  82. pmc Amino acid toxicities of Escherichia coli that are prevented by leucyl-tRNA synthetase amino acid editing
    Vrajesh A Karkhanis
    Department of Biochemistry, University of Illinois at Urbana Champaign, 600 S Mathews Ave, 419 Roger Adams Laboratory, Box B 4, Urbana, Illinois 61801 3732, USA
    J Bacteriol 189:8765-8. 2007
    Leucyl-tRNA synthetase (LeuRS) has evolved an editing function to clear misactivated amino acids. An Escherichia coli-based assay was established to identify amino acids that compromise the fidelity of LeuRS and translation...
  83. doi Two tyrosine residues outside the editing active site in Giardia lamblia leucyl-tRNA synthetase are essential for the post-transfer editing
    Xiao Long Zhou
    State Key Laboratory of Molecular Biology and Graduate School of the Chinese Academy of Sciences, Institute of Biochemistry and Cell Biology, Shanghai 200031, People s Republic of China
    Biochem Biophys Res Commun 386:510-5. 2009
    Leucyl-tRNA synthetase (LeuRS) is responsible for the Leu-tRNA(Leu) synthesis...
  84. doi Protein signatures (molecular synapomorphies) that are distinctive characteristics of the major cyanobacterial clades
    Radhey S Gupta
    Department of Biochemistry, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    Int J Syst Evol Microbiol 59:2510-26. 2009
    ..and 1 aa deletion in the RpoC protein); a clade of the low-B/A ecotype Prochlorococcus strains (5 aa deletion in LeuRS and 1 aa insert in the Ffh protein); a clade consisting of the Nostocales species/strains (subclass ..
  85. doi [Misuse of psychotropic medications in a population of subjects held for custody in the city of Paris]
    Isabelle Sec
    Urgences Médico Judiciaires, Hotel Dieu, faculté Paris Descartes, Universite Paris V, Paris, France
    Therapie 64:129-34. 2009
    ..Identify which psychotropic medications are misused and peddled in a population of subjects held for custody in the city of Paris...
  86. pmc A paradigm shift for the amino acid editing mechanism of human cytoplasmic leucyl-tRNA synthetase
    Yan Ling Joy Pang
    Department of Biochemistry, University of Illinois, 419 Roger Adams Laboratory, Box B 4, 600 South Matthews Avenue, Urbana, Illinois 61801, USA
    Biochemistry 48:8958-64. 2009
    Leucyl-tRNA synthetase (LeuRS) has been identified as a target for a novel class of boron-containing small molecules that bind to its editing active site...
  87. doi [Optimizing the relational aspects of orthodontics: the foundations of successful cooperation]
    Edmond Binhas
    Institut Binhas, BP 20057, 5 rue de Copenhague, 13742 Vitrolles Cedex, France
    Orthod Fr 80:279-90. 2009
    ..As a consequence, there can be repercussions affecting the proper economic growth of the practice. In order to find the most appropriate solutions to this problem, orthodontists must first have a solid understanding of just what it is...
  88. pmc Relationship between tap water hardness, magnesium, and calcium concentration and mortality due to ischemic heart disease or stroke in The Netherlands
    Lina J Leurs
    Maastricht University, GROW School for Oncology and Developmental Biology, Department of Epidemiology, Maastricht, The Netherlands
    Environ Health Perspect 118:414-20. 2010
    ..Conflicting results on the relationship between the hardness of drinking water and mortality related to ischemic heart disease (IHD) or stroke have been reported...
  89. doi Editing mechanism of aminoacyl-tRNA synthetases operates by a hybrid ribozyme/protein catalyst
    Yohsuke Hagiwara
    Center for Computational Sciences, University of Tsukuba, Tennodai 1 1 1, Tsukuba Science City, Ibaraki 305 8577, Japan
    J Am Chem Soc 132:2751-8. 2010
    ..We investigated theoretically the mechanism of the editing reaction for a class I enzyme, leucyl-tRNA synthetase (LeuRS), complexed with a misaminoacylated tRNA(Leu), employing ab initio hybrid quantum mechanical/molecular mechanical ..
  90. ncbi La création d'une Section étudiante dans le CIM
    Sagar Dugani
    Clin Invest Med 33:E3. 2010
    ..de communication et c'est donc par le biais de la Section étudiante du CIM que les étudiants MD+, leurs superviseurs ainsi que les responsables de programmes MD+ seront en mesure de mettre en valeur des sujets touchant ..
  91. doi Post-transfer editing by a eukaryotic leucyl-tRNA synthetase resistant to the broad-spectrum drug AN2690
    Xiao Long Zhou
    State Key Laboratory of Molecular Biology and Graduate School of the Chinese Academy of Sciences, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, The Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai, People s Republic of China
    Biochem J 430:325-33. 2010
    ..The CP1 (connective peptide 1) domain of LeuRS (leucyl-tRNA synthetase) contains the editing active site, which is the proven target for the broad-spectrum drug ..
  92. doi Promoter methylation of cyclin A1 is associated with human papillomavirus 16 induced head and neck squamous cell carcinoma independently of p53 mutation
    Daniel Weiss
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Muenster, Germany
    Mol Carcinog 50:680-8. 2011
    ..genes (TIMP3, CDH1, CDKN2A, DAPK1, transcription factor 21 (TCF21), CD44, MLH1, MGMT, RASSF1, cyclin A1 (CCNA1), LARS2, and CEBPA) was evaluated by methylation-specific polymerase chain reaction in 55 primary HNSCC and 31 controls...
  93. pmc Structural and functional role of bases 32 and 33 in the anticodon loop of yeast mitochondrial tRNAIle
    Arianna Montanari
    Department of Biology and Biotechnology, Pasteur Institute, Cenci Bolognetti Foundation, Sapienza University of Rome, 00185 Rome, Italy
    RNA 17:1983-96. 2011
    ..On the contrary, both the cognate IleRS and the noncognate LeuRS and ValRS are endowed with suppressing activities toward both mutations...
  94. doi The importance of values in predicting Turkish youth's opinions about the European Union in light of the Copenhagen Political Criteria
    M Ersin Kuşdil
    Uludag University, Bursa, Turkey
    Int J Psychol 43:988-96. 2008
    ..As for nationalism, the results showed that this variable was related negatively to reduction of the military influence, improvement of human rights and liberties, improvement of minority rights; and positively to scepticism...
  95. doi Long-term immigrant adaptation: eight-year follow-up study among immigrants from Russia and Estonia living in Finland
    Inga Jasinskaja-Lahti
    Department of Social Psychology, University of Helsinki, Helsinki, Finland
    Int J Psychol 43:6-18. 2008
    ..En huit ans, les répondants avaient amélioré leurs habiletés en finlandais sur le marché de travail...
  96. doi A comparison of fathers' and mothers' contributions in the prediction of academic performance of school-age children in Hong Kong
    Vicky C W Tam
    Department of Education Studies, Hong Kong Baptist University, Hong Kong
    Int J Psychol 44:147-56. 2009
    ..Investigations should also explore other cognitive and noncognitive domains of child outcome, different child age groups, as well as Chinese populations in various geographical regions...
  97. doi Acculturation and its determinants among adult immigrants in France
    Hisham Motkal Abu-Rayya
    School of Psychology, University of Sydney, Sydney, Australia
    Int J Psychol 44:195-203. 2009
    ..Findings revealed also that those identifying with their home country/ethnic group recorded relatively higher degrees of maladjustment than those asserting a French identification...
  98. doi The willingness to relocate to another country: the impact of cultural similarity, destination safety, and financial incentive
    Michael R Wagner
    Department of Organization and Leadership, Teachers College, Columbia University, New York, NY 10027, USA
    Int J Psychol 44:257-65. 2009
    ..Against expectations, there was no interaction between financial incentives and safety. Destination safety perceptions were relatively strong determinants of willingness to relocate...
  99. doi Human and peoples' rights: social representations among Cameroonian students
    Anna Maija Pirttilä-Backman
    University of Helsinki, Helsinki, Finland
    Int J Psychol 44:459-67. 2009
    ..Men may feel frustrated in the context of political liberalization because the freedoms are more theoretical than fulfilled; the economic crises and cultural changes have hindered their economic domination and their prerogatives...
  100. doi Effects of country size and language similarity on international attitudes: a six-nation study
    Jan Pieter van Oudenhoven
    University of Groningen, The Netherlands
    Int J Psychol 45:48-55. 2010
    ..Les nations voisines linguistiquement similaires qui diffèrent en taille sont souvent asymétriques dans leurs relations attitudinales l'une envers l'autre: les citoyens des nations plus petites tendent à voir les nations ..
  101. doi Parent-child conflict and psychological maladjustment: a mediational analysis with reciprocal filial belief and perceived threat
    Kuang Hui Yeh
    Academia Sinica, Taipei, Taiwan
    Int J Psychol 45:131-9. 2010
    ..le conflit parent-enfant nuit aux peceptions des adolescents de leur relation avec les parents ainsi que de leurs auto-perceptions dans le cadre de leur évaluation cognitive...

Research Grants3

  1. Mechanism of proofreading by class I aminoacyl-tRNA synthetases
    John J Perona; Fiscal Year: 2010
    ..sites of class I editing synthetases such as isoleucyl-, valyl- and leucyl-tRNA synthetases (IleRS, ValRS and LeuRS, respectively)...
  2. Susan A Martinis; Fiscal Year: 2014
    ..New models for leucyl-tRNA synthetase (LeuRS) have been developed to isolate pre-transfer editing activities for detailed mechanistic investigations...
  3. Philip Jon Rosenthal; Fiscal Year: 2016
    ..we will test the hypothesis that antimalarial oxaboroles inhibit a plasmodial leucyl tRNA synthetase (LeuRS). This hypothesis is based on specific activity of other oxaboroles against fungal or bacterial LeuRS...