L

Summary

Gene Symbol: L
Description: L
Alias: polymerase
Species: Human respiratory syncytial virus

Top Publications

  1. doi Mapping of CD8 T cell epitopes in human respiratory syncytial virus L protein
    Yordanka Medina-Armenteros
    Departamento de Microbiologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, Brazil
    Intervirology 57:55-64. 2014
  2. pmc Interactome analysis of the human respiratory syncytial virus RNA polymerase complex identifies protein chaperones as important cofactors that promote L-protein stability and RNA synthesis
    Diane C Munday
    Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom
    J Virol 89:917-30. 2015
  3. pmc Respiratory syncytial virus (RSV) SH and G proteins are not essential for viral replication in vitro: clinical evaluation and molecular characterization of a cold-passaged, attenuated RSV subgroup B mutant
    R A Karron
    Center for Immunization Research, Department of International Health, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 94:13961-6. 1997
  4. ncbi Intracellular localization of human respiratory syncytial virus L protein
    C Carromeu
    Departamento de Microbiologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, Brazil
    Arch Virol 152:2259-63. 2007

Scientific Experts

  • Ruth A Karron
  • Diane C Munday
  • Armando M Ventura
  • Yordanka Medina-Armenteros
  • C Carromeu
  • Sarah Louise Noton
  • Jean François Eléouët
  • Nikki Smith
  • Fernando M Simabuco
  • Marie Galloux
  • Andrew J Easton
  • Stuart D Armstrong
  • Jenna Fix
  • John N Barr
  • Olivier Touzelet
  • Julian A Hiscox
  • Paul Digard
  • David J Hughes
  • Marie Anne Rameix-Welti
  • Rachel Fearns
  • Waleed Aljabr
  • Andressa Peres de Oliveira
  • Weining Wu
  • Jenna M Dawson
  • Cassiano Carromeu
  • Catarina J M Braga
  • Luis E Farinha-Arcieri
  • Rodrigo E Tamura
  • L E Farinha Arcieri
  • F M Simabuco
  • R E Tamura
  • A M Ventura

Detail Information

Publications4

  1. doi Mapping of CD8 T cell epitopes in human respiratory syncytial virus L protein
    Yordanka Medina-Armenteros
    Departamento de Microbiologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, Brazil
    Intervirology 57:55-64. 2014
    ..human respiratory syncytial virus (hRSV)-specific cytotoxic T lymphocytes and symptom reduction, and that the polymerase (structural L protein) is highly conserved among different strains, this work aimed to identify the CD8 T cell ..
  2. pmc Interactome analysis of the human respiratory syncytial virus RNA polymerase complex identifies protein chaperones as important cofactors that promote L-protein stability and RNA synthesis
    Diane C Munday
    Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom
    J Virol 89:917-30. 2015
    The human respiratory syncytial virus (HRSV) core viral RNA polymerase comprises the large polymerase protein (L) and its cofactor, the phosphoprotein (P), which associate with the viral ribonucleoprotein complex to replicate the genome ..
  3. pmc Respiratory syncytial virus (RSV) SH and G proteins are not essential for viral replication in vitro: clinical evaluation and molecular characterization of a cold-passaged, attenuated RSV subgroup B mutant
    R A Karron
    Center for Immunization Research, Department of International Health, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 94:13961-6. 1997
    ..The requirement of SH and G for efficient replication in vivo suggests that selective deletion of one or both of these RSV genes may provide an alternative or additive strategy for developing an optimally attenuated vaccine candidate...
  4. ncbi Intracellular localization of human respiratory syncytial virus L protein
    C Carromeu
    Departamento de Microbiologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, Brazil
    Arch Virol 152:2259-63. 2007
    ..syncytial virus (hRSV) genome is carried out by the ribonucleocapsid complex (RNA together with N, P, M2-1 and L proteins), with the L protein being responsible for all enzymatic activities...