Kv4.3

Summary

Gene Symbol: Kv4.3
Description: potassium voltage-gated channel subfamily D member 3
Alias: BRGDA9, KCND3L, KCND3S, KSHIVB, KV4.3, SCA19, SCA22, potassium voltage-gated channel subfamily D member 3, potassium channel, voltage gated Shal related subfamily D, member 3, potassium ionic channel Kv4.3, potassium voltage-gated channel long, potassium voltage-gated channel, Shal-related subfamily, member 3, sha1-related potassium channel Kv4.3, voltage-gated K+ channel, voltage-gated potassium channel subunit Kv4.3
Species: human

Top Publications

  1. ncbi Voltage-gated potassium channel Kv1.3 regulates GLUT4 trafficking to the plasma membrane via a Ca2+-dependent mechanism
    Yanyan Li
    Department of Medicine, Yale University School of Medicine, New Haven, CT 06520 8029, USA
    Am J Physiol Cell Physiol 290:C345-51. 2006
  2. ncbi Characteristics of IA currents in adult rabbit cerebellar Purkinje cells
    Desheng Wang
    Department of Physiology and Pharmacology and Blanchette Rockefeller Neurosciences Institute, West Virginia University School of Medicine, Morgantown, 26506, USA
    Brain Res 1096:85-96. 2006
  3. ncbi KCNE3 is an inhibitory subunit of the Kv4.3 potassium channel
    Alicia Lundby
    The Danish National Research Foundation Centre for Cardiac Arrhythmia, Department of Medical Physiology, University of Copenhagen, The Panum Institute, 3 Blegdamsvej, DK 2200 Copenhagen N, Denmark
    Biochem Biophys Res Commun 346:958-67. 2006
  4. doi Nitric oxide inhibits Kv4.3 and human cardiac transient outward potassium current (Ito1)
    Ricardo Gomez
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Cardiovasc Res 80:375-84. 2008
  5. pmc Transient outward current (I(to)) gain-of-function mutations in the KCND3-encoded Kv4.3 potassium channel and Brugada syndrome
    John R Giudicessi
    Department of Medicine Division of Cardiovascular Diseases, Department of Pediatrics Division of Pediatric Cardiology, and Department of Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Rochester, Minnesota, USA
    Heart Rhythm 8:1024-32. 2011
  6. pmc Expression and function of dipeptidyl-aminopeptidase-like protein 6 as a putative beta-subunit of human cardiac transient outward current encoded by Kv4.3
    Susanne Radicke
    Department of Pharmacology and Toxicology, Medical Faculty, Dresden University of Technology, Fetscherstr 74, Dresden, 01307 Germany
    J Physiol 565:751-6. 2005
  7. ncbi Cloning and expression of the human kv4.3 potassium channel
    D Dilks
    CNS Research, Wyeth Ayerst Research, Princeton, New Jersey 08543, USA
    J Neurophysiol 81:1974-7. 1999
  8. ncbi Modulation of Kv4.3 current by accessory subunits
    Isabelle Deschenes
    Department of Medicine, Institute of Molecular Cardiobiology, Division of Cardiology, Johns Hopkins University, Baltimore, MD 21205, USA
    FEBS Lett 528:183-8. 2002
  9. ncbi Effect of mitochondrial KATP channel on voltage-gated K+ channel in 24 hour-hypoxic human pulmonary artery smooth muscle cells
    Tao Wang
    Department of Respiratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Chin Med J (Engl) 118:12-9. 2005
  10. ncbi Nicotine is a potent blocker of the cardiac A-type K(+) channels. Effects on cloned Kv4.3 channels and native transient outward current
    H Wang
    Department of Medicine and Research Center, Montreal Heart Institute, University of Montreal, Quebec, Canada
    Circulation 102:1165-71. 2000

Detail Information

Publications237 found, 100 shown here

  1. ncbi Voltage-gated potassium channel Kv1.3 regulates GLUT4 trafficking to the plasma membrane via a Ca2+-dependent mechanism
    Yanyan Li
    Department of Medicine, Yale University School of Medicine, New Haven, CT 06520 8029, USA
    Am J Physiol Cell Physiol 290:C345-51. 2006
    ..3 channel activity is mediated by an increase in GLUT4 protein at the plasma membrane, which occurs largely through a Ca(2+)-dependent process...
  2. ncbi Characteristics of IA currents in adult rabbit cerebellar Purkinje cells
    Desheng Wang
    Department of Physiology and Pharmacology and Blanchette Rockefeller Neurosciences Institute, West Virginia University School of Medicine, Morgantown, 26506, USA
    Brain Res 1096:85-96. 2006
    ....
  3. ncbi KCNE3 is an inhibitory subunit of the Kv4.3 potassium channel
    Alicia Lundby
    The Danish National Research Foundation Centre for Cardiac Arrhythmia, Department of Medical Physiology, University of Copenhagen, The Panum Institute, 3 Blegdamsvej, DK 2200 Copenhagen N, Denmark
    Biochem Biophys Res Commun 346:958-67. 2006
    ..3 within the Kv4 channel family. Kv4.3 has previously been shown to interact with a number of beta-subunits, but none of the described subunit-interactions exert an inhibitory effect on the Kv4.3 current...
  4. doi Nitric oxide inhibits Kv4.3 and human cardiac transient outward potassium current (Ito1)
    Ricardo Gomez
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Cardiovasc Res 80:375-84. 2008
    ..3 (I(Kv4.3)) and on human transient outward K(+) (I(to1)) currents as well as the signalling pathways responsible for them. We also analysed the expression of NO synthase 3 (NOS3) in patients with CAF...
  5. pmc Transient outward current (I(to)) gain-of-function mutations in the KCND3-encoded Kv4.3 potassium channel and Brugada syndrome
    John R Giudicessi
    Department of Medicine Division of Cardiovascular Diseases, Department of Pediatrics Division of Pediatric Cardiology, and Department of Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Rochester, Minnesota, USA
    Heart Rhythm 8:1024-32. 2011
    ..Given the prominent role of the transient outward current (I(to)) in BrS pathogenesis, we hypothesized that rare gain-of-function mutations in KCND3 may serve as a pathogenic substrate for BrS...
  6. pmc Expression and function of dipeptidyl-aminopeptidase-like protein 6 as a putative beta-subunit of human cardiac transient outward current encoded by Kv4.3
    Susanne Radicke
    Department of Pharmacology and Toxicology, Medical Faculty, Dresden University of Technology, Fetscherstr 74, Dresden, 01307 Germany
    J Physiol 565:751-6. 2005
    ..3 and KChIP2a produced similar current kinetics as in human ventricular myocytes. We therefore propose that DPPX is an essential component of the native cardiac I(to) channel complex in human heart...
  7. ncbi Cloning and expression of the human kv4.3 potassium channel
    D Dilks
    CNS Research, Wyeth Ayerst Research, Princeton, New Jersey 08543, USA
    J Neurophysiol 81:1974-7. 1999
    ..There was little difference in the recovery from inactivation or in the kinetics of inactivation between the two isoforms of the channel...
  8. ncbi Modulation of Kv4.3 current by accessory subunits
    Isabelle Deschenes
    Department of Medicine, Institute of Molecular Cardiobiology, Division of Cardiology, Johns Hopkins University, Baltimore, MD 21205, USA
    FEBS Lett 528:183-8. 2002
    ..3 current. hKv4.3 promiscuously assembles with ancillary subunits in vitro, functionally modifying the encoded currents; however, the physiological significance is uncertain...
  9. ncbi Effect of mitochondrial KATP channel on voltage-gated K+ channel in 24 hour-hypoxic human pulmonary artery smooth muscle cells
    Tao Wang
    Department of Respiratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Chin Med J (Engl) 118:12-9. 2005
    ..This study investigated the changes of cell membrane potential and Kv channel in cultured human pulmonary artery smooth muscle cell (hPASMC) exposed to 24 hour-hypoxia, and explored the role of MitoKATP and DeltaPsim in this condition...
  10. ncbi Nicotine is a potent blocker of the cardiac A-type K(+) channels. Effects on cloned Kv4.3 channels and native transient outward current
    H Wang
    Department of Medicine and Research Center, Montreal Heart Institute, University of Montreal, Quebec, Canada
    Circulation 102:1165-71. 2000
    ..Nicotine is a main constituent of cigarette smoke and smokeless tobacco, known to increase the risk of sudden cardiac death. This study aimed at establishing ionic mechanisms underlying potential electrophysiological effects of nicotine...
  11. ncbi Na(+) entry through AMPA receptors results in voltage-gated k(+) channel blockade in cultured rat spinal cord motoneurons
    P Van Damme
    Laboratory for Neurobiology, Department of Neuroscience, University of Leuven, Belgium
    J Neurophysiol 88:965-72. 2002
    ..These findings demonstrate that Na(+) influx through AMPA receptors results in blockade of voltage-gated K(+) channels...
  12. pmc Role of potassium channels in the antinociception induced by agonists of alpha2-adrenoceptors
    N Galeotti
    Department of Preclinical and Clinical Pharmacology, Florence, Italy
    Br J Pharmacol 126:1214-20. 1999
    ..7. The present data demonstrate that both K(ATP) and mKv1.1 K+ channels represent an important step in the transduction mechanism underlying central antinociception induced by activation of alpha2 adrenoceptors...
  13. ncbi Expression of voltage-gated K+ channels in human atrium
    Federica Bertaso
    Cell Signalling Group, Department of Renal Medicine, Guy s, King s and St Thomas School of Medicine, King s College London, Bessemer Road, London, SE5 7PJ, United Kingdom
    Basic Res Cardiol 97:424-33. 2002
    ..2 and Kv2.1 is consistent with the major contribution of Kv1.5 to this current. The physiological significance of the expression of KvLQT1 and Kv1.4 mRNA in the human atrium warrants further investigation...
  14. pmc The role of voltage-gated potassium channels in the regulation of mouse uterine contractility
    Ryan C Smith
    epartment of Pharmacology, Creighton University Medical Center, Omaha, USA, NE 68178, USA
    Reprod Biol Endocrinol 5:41. 2007
    ....
  15. doi Voltage-gated potassium channels in IB4-positive colonic sensory neurons mediate visceral hypersensitivity in the rat
    Ai Hua Qian
    Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
    Am J Gastroenterol 104:2014-27. 2009
    ..This study was designed to examine changes in the excitability and alterations of voltage-gated K+ currents in subpopulations of colonic dorsal root ganglion (DRG) neurons in a rat model of IBS-like visceral hypersensitivity...
  16. ncbi Effects of voltage-gated ion channel modulators on rat prostatic cancer cell proliferation: comparison of strongly and weakly metastatic cell lines
    S P Fraser
    Neurobiology Group, Department of Biology, Imperial College of Science, Technology and Medicine, London, UK
    Prostate 44:61-76. 2000
    ..In the present study, the possible contribution of voltage-gated ion channel activity to the proliferation of these cell lines was investigated, in a comparative approach...
  17. ncbi Comparison of ion-channel subunit expression in canine cardiac Purkinje fibers and ventricular muscle
    Wei Han
    Department of Medicine and Research Center, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada
    Circ Res 91:790-7. 2002
    ..We conclude that ion-channel subunit expression in PFs differs from that in VM in ways that are consistent with, and shed light on the molecular basis of, well-recognized fundamental PF ionic properties...
  18. ncbi Light and electron microscopic analysis of KChIP and Kv4 localization in rat cerebellar granule cells
    Brian W Strassle
    Neuroscience Division, Wyeth Research, Princeton, New Jersey 08543, USA
    J Comp Neurol 484:144-55. 2005
    ..2 and KChIP1, and perhaps also KChIP3 and 4, play a critical role in regulating postsynaptic excitability at the cerebellar mossy-fiber/granule cell synapse...
  19. ncbi Immunoisolation of a K+ channel from basolateral membranes of Necturus enterocytes
    W P Dubinsky
    Department of Physiology and Cell Biology, University of Texas Medical School, Houston 77225
    Am J Physiol 265:C548-55. 1993
    ....
  20. pmc Distinct modes of channel gating underlie inactivation of somatic K+ current in rat hippocampal pyramidal cells in vitro
    J L Bossu
    Brain Research Institute, University of Zurich, Switzerland
    J Physiol 495:383-97. 1996
    ..These gating modes are probably under the control of intracellular factors that remain to be identified...
  21. ncbi Genomic organization of the KCNQ1 K+ channel gene and identification of C-terminal mutations in the long-QT syndrome
    N Neyroud
    INSERM U153, Institut de Myologie, Hopital Pitie Salpetriere, Paris, France
    Circ Res 84:290-7. 1999
    ..Such mutations in the C-terminal domain of the gene may be more frequent than previously expected, because this region has not been analyzed so far. This could explain the low percentage of mutations found in large LQTS cohorts...
  22. pmc KChIP2 attenuates cardiac hypertrophy through regulation of Ito and intracellular calcium signaling
    Hongwei Jin
    Cardiovascular Research Center, Mount Sinai School of Medicine, Atran Building AB5 10, One Gustave L Levy Place, Box 1030, New York, NY 10029 6574, USA
    J Mol Cell Cardiol 48:1169-79. 2010
    ..4. Altogether, these data show that KChIP2 can attenuate cardiac hypertrophy possibly through modulation of intracellular calcium concentration and calcineurin/NFAT pathway...
  23. ncbi Temporomandibular joint inflammation decreases the voltage-gated K+ channel subtype 1.4-immunoreactivity of trigeminal ganglion neurons in rats
    Mamoru Takeda
    Department of Physiology, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo 102 8159, Japan
    Eur J Pain 12:189-95. 2008
    ..These results lead us to suggest that Kv channel openers may be a potential therapeutic agents for prevention of mechanical allodynia...
  24. doi Hypoxia sensing in the fetal chicken femoral artery is mediated by the mitochondrial electron transport chain
    Bea Zoer
    University Hospital Maastricht, P Debyelaan 25, AZ Maastricht, The Netherlands
    Am J Physiol Regul Integr Comp Physiol 298:R1026-34. 2010
    ..In conclusion, our experiments suggest that the mETC plays a critical role in O(2) sensing in fetal chicken femoral arteries. In contrast, hypoxia-induced relaxation appears not to be mediated by ROS or K(+) channels...
  25. pmc Downregulated Kv4.3 expression in the RVLM as a potential mechanism for sympathoexcitation in rats with chronic heart failure
    Lie Gao
    Dept of Cellular and Integrative Physiology, Univ of Nebraska Medical Center, Omaha, 68198 5850, USA
    Am J Physiol Heart Circ Physiol 298:H945-55. 2010
    ..3 expression and subsequent decrease in K(+) current, thereby increasing the excitability of neurons in the RVLM. The ANG II-induced inhibition of Kv4.3 mRNA expression was mediated by ANG II-AT(1)R-ROS-p38 MAPK signaling...
  26. pmc Spironolactone and its main metabolite canrenoic acid block hKv1.5, Kv4.3 and Kv7.1 + minK channels
    Ricardo Gomez
    Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain
    Br J Pharmacol 146:146-61. 2005
    ..Blockade of these cardiac K(+) currents, together with the antagonism of the aldosterone proarrhythmic effects produced by SP, might be highly desirable for the treatment of supraventricular arrhythmias...
  27. doi Ion channel subunit expression changes in cardiac Purkinje fibers: a potential role in conduction abnormalities associated with congestive heart failure
    Ange Maguy
    Department of Medicine, Montreal Heart Institute and Universite de Montreal, Quebec, Canada
    Circ Res 104:1113-22. 2009
    ....
  28. pmc Psychotomimetic sigma-ligands, dexoxadrol and phencyclidine block the same presynaptic potassium channel in rat brain
    D K Bartschat
    Department of Physiology, University of Maryland School of Medicine, Baltimore 21201
    J Physiol 403:341-53. 1988
    ..Our findings are also consistent with the view that some of the behavioural manifestations of PCP intoxication are mediated by block of presynaptic K+ channels...
  29. pmc Comparison of K+-channel genes within the genomes of Anopheles gambiae and Drosophila melanogaster
    Thomas J McCormack
    Department of Chemistry, University of Florida, Gainesville, FL 32611, USA, Present address Department of Pharmacology and Therapeutics, University of Florida, Gainesville, FL 32610 0267, USA
    Genome Biol 4:R58. 2003
    ....
  30. pmc Altered expression and localization of hippocampal A-type potassium channel subunits in the pilocarpine-induced model of temporal lobe epilepsy
    M M Monaghan
    Neuroscience, Wyeth Discovery Research, CN8000, Princeton, NJ 08543, USA
    Neuroscience 156:550-62. 2008
    ..These changes in A-type Kv channel expression may contribute to hyperexcitability of dendrites in the associated hippocampal circuits as observed in previous studies of the effects of pilocarpine-induced SE...
  31. pmc Targeting the voltage sensor of Kv7.2 voltage-gated K+ channels with a new gating-modifier
    Asher Peretz
    Department of Physiology and Pharmacology, The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Proc Natl Acad Sci U S A 107:15637-42. 2010
    ..Our data provide a structural framework for designing unique gating-modifiers targeted to the VSD of voltage-gated cation channels and used for the treatment of hyperexcitability disorders...
  32. doi Effects of lobeline, a nicotinic receptor ligand, on the cloned Kv1.5
    Imju Jeong
    Department of Physiology, Medical Research Center, College of Medicine, The Catholic University of Korea, 505 Banpo Dong, Socho gu, Seoul, 137 701, South Korea
    Pflugers Arch 460:851-62. 2010
    ..7, 28.2, and 0.34 μM, respectively. These results indicate that lobeline produces a concentration-, time-, voltage-, and use-dependent inhibition of Kv1.5, which can be interpreted as an open-channel block mechanism...
  33. pmc Regional and tissue specific transcript signatures of ion channel genes in the non-diseased human heart
    Nathalie Gaborit
    INSERM U533, Nantes, France
    J Physiol 582:675-93. 2007
    ..Concordance with previous functional studies suggests that regional regulation of cardiac ion-current expression may be primarily transcriptional...
  34. pmc Post-transcriptional gene silencing of KChIP2 and Navbeta1 in neonatal rat cardiac myocytes reveals a functional association between Na and Ito currents
    Isabelle Deschenes
    Department of Medicine, Division of Cardiology, Johns Hopkins University, 720 N Rutland Avenue, Ross 844, Baltimore, MD 21205, USA
    J Mol Cell Cardiol 45:336-46. 2008
    ..x proteins resulting in remarkably decreased I(Na) and I(to). These data are consistent with a novel structural and functional association of I(Na) and I(to) in NRVMs...
  35. pmc Estrogen contributes to gender differences in mouse ventricular repolarization
    Tomoaki Saito
    Department of Anesthesiology, Division of Molecular Medicine, David Geffen School of Medicine at University of California Los Angeles, CA 90095 7115, USA
    Circ Res 105:343-52. 2009
    ..Fast-transient outward K(+) (I(to,f)) and ultrarapid delayed rectifier K(+) currents (I(K,slow), also known as I(Kur)) contribute to mouse cardiac repolarization. Gender studies on these currents have reported conflicting results...
  36. ncbi Oxygen dilation in fetal pulmonary arterioles: role of K(+) channels
    J R Gosche
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Surg Res 97:159-63. 2001
    ..We have examined the effect of potassium channel blockers on oxygen-induced vasodilation in isolated pulmonary arterioles from fetal rats at term...
  37. ncbi A method for the simultaneous analysis of mRNA levels of multiple cardiac ion channels with a multi-probe RNase protection assay
    Yu Ki Iwasaki
    The First Department of Internal Medicine, Nippon Medical School, 1 1 5, Sendagi, Bunkyo ku, Tokyo 1138603, Japan
    Europace 8:1011-5. 2006
    ..To investigate the underlying mechanisms of the latter, electrophysiological alterations would require a simultaneous and comprehensive analysis of the mRNA level of the ion channel genes...
  38. pmc Characterization of a voltage-gated K+ channel beta subunit expressed in human heart
    S K England
    Department of Molecular Physiology, Vanderbilt University of Medicine, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 92:6309-13. 1995
    ..These data confirm the presence of functionally important K+ channel beta subunits in human heart and indicate that beta-subunit composition must be accounted for when comparing cloned channels with endogenous cardiac currents...
  39. ncbi Activity of voltage-gated K+ channels is associated with cell proliferation and Ca2+ influx in carcinoma cells of colon cancer
    X Yao
    Department of Physiology, Faculty of Medicine, Chinese University of Hong Kong, Shatin
    Life Sci 65:55-62. 1999
    ..Therefore, it is likely that K+ channel activity may modulate Ca2+ influx into colon cancer cells, and subsequently modulate the proliferation of these cells...
  40. ncbi Regulation of the voltage gated K+ channel Kv1.3 by the ubiquitin ligase Nedd4-2 and the serum and glucocorticoid inducible kinase SGK1
    G Henke
    Department of Physiology, University of Tubingen, Tubingen, Germany
    J Cell Physiol 199:194-9. 2004
    ..3 in both, presence and absence of Nedd4-2. It is concluded that Kv1.3 is downregulated by Nedd4-2 and stimulates by SGK1, SGK2, and SGK3. The data thus disclose a novel mechanism of Kv1.3 channel regulation...
  41. pmc Effect of S5P alpha-helix charge mutants on inactivation of hERG K+ channels
    C E Clarke
    Department of Medicine, University of New South Wales, St Vincent s Clinical School, Darlinghurst, NSW 2010, Australia
    J Physiol 573:291-304. 2006
    ..We suggest that inactivation of hERG involves the interaction of this face of the S5P alpha-helix with a charged residue on the remainder of the outer pore domain of the channel...
  42. pmc Reduction in voltage-gated K+ channel activity in primary sensory neurons in painful diabetic neuropathy: role of brain-derived neurotrophic factor
    Xue Hong Cao
    Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Neurochem 114:1460-75. 2010
    ..Increased BDNF activity in these neurons likely contributes to the reduction in Kv channel function through TrkB receptor stimulation in painful diabetic neuropathy...
  43. ncbi Images of purified Shaker potassium channels
    M Li
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco 94143 0724
    Curr Biol 4:110-5. 1994
    ..Until now, however, no K+ channel, nor any other member of the superfamily of voltage-gated ion channels, has been characterized by electron microscopy or other structural analysis...
  44. ncbi Voltage-activated potassium channels in mammalian neurons and their block by novel pharmacological agents
    A Mathie
    Department of Pharmacology, Royal Free Hospital, School of Medicine, London, UK
    Gen Pharmacol 30:13-24. 1998
    ..These compounds are weak bases and it appears that their uncharged form is required for activity. These compounds may provide a useful starting point for the rational design of novel selective K channel blocking agents...
  45. ncbi High glucose impairs voltage-gated K(+) channel current in rat small coronary arteries
    Y Liu
    Department of Internal Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Circ Res 89:146-52. 2001
    ..We speculate that this O(2)(.-)-induced impairment may reduce vasodilator responsiveness in the coronary circulation of subjects with coronary disease or its risk factors...
  46. pmc Coupling between voltage sensors and activation gate in voltage-gated K+ channels
    Zhe Lu
    Department of Physiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Gen Physiol 120:663-76. 2002
    ..One sequence is the so called S4-S5 linker distal to the voltage-sensing S4, while the other is around the COOH-terminal end of S6, a region containing the actual gate-forming residues...
  47. ncbi Complex expression and localization of inactivating Kv channels in cultured hippocampal astrocytes
    Lane K Bekar
    Department of Physiology, University of Saskatchewan, Rm B39 Health Sciences Bldg, Saskatoon, SK, S7N 5E5, Canada
    J Neurophysiol 93:1699-709. 2005
    ..However, this study suggests that they enable astrocytes to respond rapidly with membrane voltage oscillations to high-frequency incoming signals, possibly synchronizing astrocyte function to neuronal activity...
  48. pmc Effects of MiRP1 and DPP6 beta-subunits on the blockade induced by flecainide of Kv4.3/KChIP2 channels
    S Radicke
    Department of Pharmacology, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain
    Br J Pharmacol 154:774-86. 2008
    ..beta-Subunits can alter the pharmacological response of Ito; therefore, we analysed the effects of flecainide on Kv4.3/KChIP2 channels coassembled with MiRP1 and/or DPP6 beta-subunits...
  49. ncbi Characterization of the transcription unit of mouse Kv1.4, a voltage-gated potassium channel gene
    R S Wymore
    Department of Physiology, University of California, Irvine, California 92717, USA
    J Biol Chem 271:15629-34. 1996
    ..One region enhances activity of this promoter. Thus, transcriptional and post-transcriptional regulation of mKv1.4, coupled with selective usage of the two alternate Kv1.4 mRNAs, may modulate the levels of functional Kv1.4 channels...
  50. ncbi Developmental differences in Ca2+-activated K+ channel activity in ovine basilar artery
    Mike T Lin
    Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
    Am J Physiol Heart Circ Physiol 285:H701-9. 2003
    ..e., the calcium set points) at 0 mV were 8.8 and 4.7 microM for adult and fetal myocytes, respectively. Thus the increased BKCa current density in fetal myocytes appears to result from a lower calcium set point...
  51. ncbi The effects of putative K+ channel blockers on volume regulation of murine spermatozoa
    J P Barfield
    Institute of Reproductive Medicine of the University, D 48129 Munster, Germany
    Biol Reprod 72:1275-81. 2005
    ..Volume regulation of spermatozoa may involve novel voltage-gated and pH-sensitive potassium channels, which could be valuable targets for the development of a posttesticular male contraceptive...
  52. ncbi A family of K+ channel ancillary subunits regulate taste sensitivity in Caenorhabditis elegans
    Ki Ho Park
    Department of Physiology and Biophysics, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 683 Hoes Lane, Piscataway, NJ 08854, USA
    J Biol Chem 280:21893-9. 2005
    ..Thus, it appears that the chemosensory apparatus of C. elegans uses sensory thresholds and that a voltage-gated K(+) channel is specifically required for this mechanism...
  53. ncbi Electrophysiological characterization of three non-synonymous single nucleotide polymorphisms (R87Q, A251T, and P307S) found in hKv1.5
    Isabelle Plante
    Quebec Heart Institute, Laval Hospital Research Centre, and Faculty of Pharmacy, Laval University, Sainte Foy, Quebec, G1V 4G5, Canada
    Pflugers Arch 452:316-23. 2006
    ..SNPs properties were not reproduced when expressed in the HEK293 cell line, suggesting that the regulatory beta-subunit present in CHO cells (and the human heart) is essential for the SNPs effects that we have observed...
  54. ncbi Functional antagonism of voltage-gated K+ channel α-subunits in the developing brain ventricular system
    Hongyuan Shen
    Institute of Molecular and Cell Biology, Singapore
    Development 143:4249-4260. 2016
    ..This demonstrates the dynamic interplay between potassium channel subunits in the neuroepithelium as a novel and crucial regulator of ventricular development in the vertebrate brain...
  55. ncbi Molecular cloning and characterization of two voltage-gated K+ channel cDNAs from human ventricle
    M M Tamkun
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37205
    FASEB J 5:331-7. 1991
    ..Both channel transcripts are present in ventricle at levels equivalent to voltage-gated Na+ channels. Analysis of the gene encoding HK1 suggests the coding sequence is intronless and is represented once in the human genome...
  56. ncbi A novel beta subunit increases rate of inactivation of specific voltage-gated potassium channel alpha subunits
    M J Morales
    Department of Pharmacology, Duke University Medical Center, Durham, North Carolina 27710
    J Biol Chem 270:6272-7. 1995
    ..This study shows that voltage-gated K+ channel beta subunits are present outside the central nervous system, and that at least one member of this family selectively modulates inactivation of K+ channel alpha subunits...
  57. ncbi Localization of Kv1.1 and Kv1.2, two K channel proteins, to synaptic terminals, somata, and dendrites in the mouse brain
    H Wang
    Geriatric Research Education and Clinical Center, VA Medical Center, Seattle, Washington 98108
    J Neurosci 14:4588-99. 1994
    ..This overlapping yet differential pattern of expression and specific subcellular localization may contribute to the unique profile of excitability displayed by a particular neuron...
  58. ncbi Mapping the receptor site for hanatoxin, a gating modifier of voltage-dependent K+ channels
    K J Swartz
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Neuron 18:675-82. 1997
    ..These results suggest that residues near the outer edges of S3 and S4 form the HaTx binding sites and are eccentrically located at least 15 A from the central pore axis on the surface of voltage-gated K+ channels...
  59. ncbi Ion channels: a first view of K+ channels in atomic glory
    M S Sansom
    Laboratory of Molecular Biophysics, University of Oxford, UK
    Curr Biol 8:R450-2. 1998
    ..These provide our first real structural insights into possible mechanisms of ion selectivity and permeation for K+ channels...
  60. pmc Elimination of the transient outward current and action potential prolongation in mouse atrial myocytes expressing a dominant negative Kv4 alpha subunit
    H Xu
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, MO 63110, USA
    J Physiol 519:11-21. 1999
    ..2W362F-expressing animals...
  61. ncbi Voltage-gated K(+)Channel, Kv4.2, localizes predominantly to the transverse-axial tubular system of the rat myocyte
    S Takeuchi
    Department of Circulation, Nagoya University, Nagoya, Japan
    J Mol Cell Cardiol 32:1361-9. 2000
    ..The extensive distribution of Kv4.2 on the entire cell membrane of myocytes would provide rat myocardial cells with a large capability for the transport of K(+)ions through the channels in the repolarization phase...
  62. pmc Heterogeneous expression of repolarizing, voltage-gated K+ currents in adult mouse ventricles
    Sylvain Brunet
    Department of Molecular Biology and Pharmacology, Washington University Medical School, 660 South Euclid Avenue, Box 8103, St Louis, MO 63110 1093, USA
    J Physiol 559:103-20. 2004
    ....
  63. ncbi Blockers of the Kv1.5 channel for the treatment of atrial arrhythmias
    Joachim Brendel
    Aventis Pharma Deutschland GmbH, Medicinal Chemistry, G878, D 65926 Frankfurt Main, Germany
    Curr Med Chem Cardiovasc Hematol Agents 1:273-87. 2003
    ..5 blocker. Significant block of IK1, HERG or sodium channels, however, clearly leads to loss of atrial selectivity and increases the risk of lethal ventricular proarrhythmia...
  64. ncbi Insulin-activated, K+-channel-sensitive Akt pathway is primary mediator of ML-1 cell proliferation
    Taylor B Guo
    Health Science Center, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai Second Medical University, Shanghai, China
    Am J Physiol Cell Physiol 289:C257-63. 2005
    ..Our results strongly suggest that a 4-AP-sensitive K(+) channel activity plays an important role in controlling proliferation of ML-1 cells by affecting the activation of multiple signal transduction processes induced by insulin...
  65. ncbi Blockers of the delayed-rectifier potassium current in pancreatic beta-cells enhance glucose-dependent insulin secretion
    James Herrington
    Department of Ion Channels, Merck Research Laboratories, RY80N C31, P O Box 2000, Rahway, NJ 07065 0900, USA
    Diabetes 55:1034-42. 2006
    ..These data point to a mechanism for specific enhancement of glucose-dependent insulin secretion by applying blockers of the beta-cell I(DR), which may provide advantages over currently used therapies for the treatment of type 2 diabetes...
  66. ncbi Differential calcineurin/NFATc3 activity contributes to the Ito transmural gradient in the mouse heart
    Charles F Rossow
    Department of Physiology and Biophysics, University of Washington, Seattle, WA 98118, USA
    Circ Res 98:1306-13. 2006
    ..2. Based on these data, we conclude that calcineurin and NFATc3 constitute a Ca(2+)-driven signaling module that contributes to the nonuniform distribution of Kv4 expression, and hence Ito function, in the mouse left ventricle...
  67. ncbi Block of neural Kv1.1 potassium channels for neuroinflammatory disease therapy
    Evelyne Beraud
    Service d Immunologie, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
    Ann Neurol 60:586-96. 2006
    ..We asked whether blockade of voltage-gated K+ channel Kv1.1, whose altered axonal localization during myelin insult and remyelination may disturb nerve conduction, treats experimental autoimmune encephalomyelitis (EAE)...
  68. ncbi Differential expression of I(A) channel subunits Kv4.2 and Kv4.3 in mouse visual cortical neurons and synapses
    Andreas Burkhalter
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 26:12274-82. 2006
    ..Thus, the synapse-specific distribution of Kv4 channels functions to optimize dendritic excitation and the association between presynaptic and postsynaptic activity...
  69. ncbi Electrophysiological properties of human adipose tissue-derived stem cells
    Xiaowen Bai
    Department of Molecular Pathology, University of Texas, MD Anderson Cancer Center, Houston, Texas 77054, USA
    Am J Physiol Cell Physiol 293:C1539-50. 2007
    ..TTX) are present in undifferentiated hASCs and their potential physiological function in these cells as a basic understanding for future in vitro experiments and in vivo clinical investigations...
  70. ncbi [Effects of rapid atrial pacing on L-type calcium channel subunits and potassium channel Kv4.3 expressions in rabbits]
    Rui Yan Ma
    Department of Cardiovascular Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China
    Zhonghua Xin Xue Guan Bing Za Zhi 35:1111-5. 2007
    ..To investigate rapid atrial pacing (RAP) induced atrial ultrastructural changes and mRNA and protein expression changes of L-type calcium channel subunits and potassium channel Kv4.3 in a rabbit model...
  71. pmc Regulation of Kv4 channel expression in failing rat heart by the thioredoxin system
    Xun Li
    Dept of Cellular and Integrative Physiology, Univ of Nebraska Medical Ctr, Omaha, NE 68198 5850, USA
    Am J Physiol Heart Circ Physiol 295:H416-24. 2008
    ..These data suggest that the expression of Kv4.x channels is redox-regulated by the thioredoxin system, which may be a novel therapeutic target to reverse or limit electrical remodeling of the failing heart...
  72. pmc Distribution of voltage-gated potassium and hyperpolarization-activated channels in sensory afferent fibers in the rat carotid body
    Maria Buniel
    Rammelkamp Center for Education and Research, MetroHealth Campus of Case Western Reserve University, Cleveland, Ohio 44109 1998, USA
    J Comp Neurol 510:367-77. 2008
    ..4, Kv1.5, Kv4.3, and K(Ca) (BK). The role of these channels should be considered in interpretation of the fiber discharge in response to perturbation of the carotid body environment...
  73. ncbi [Influence of 4-aminopyridine on human ovarian luteinized granulosa cell proliferation, production, and apoptosis through inhibiting voltage-gated K+ channel]
    Zhi Ming Zhao
    Department of Reproductive Medicine, The Second Hospital, Hebei Medical University, Shijiazhuang 050000, China
    Zhonghua Fu Chan Ke Za Zhi 43:918-22. 2008
    ..To study the influence of 4-aminopyridine (4-AP) on proliferation, production, and apoptosis through inhibiting voltage-gated K(+) channel (Kv) in ovarian luteinized granulosa cells...
  74. pmc Auto-phosphorylation of a voltage-gated K+ channel controls non-associative learning
    Shi Qing Cai
    Department of Physiology and Biophysics, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ, USA
    EMBO J 28:1601-11. 2009
    ..In the auto-phosphorylated state the channel acts to induce neuronal adaptation to mechanical stimulation. Taken together, these data establish a new mechanism of dynamic regulation of electrical signalling in the nervous system...
  75. ncbi [Atrial myocytes KChIP2 mRNA expression in rheumatic heart disease patients with atrial fibrillation]
    Xiao qiu Tan
    Department of Myocardium Electrophysiology, Institute of Cardiovasology, Luzhou Medical College, Luzhou 646000, China
    Zhonghua Xin Xue Guan Bing Za Zhi 37:509-13. 2009
    ..To detect the KChIP2 mRNA level in rheumatic heart disease patients with or without atrial fibrillation (AF) by real-time PCR...
  76. pmc A folding zone in the ribosomal exit tunnel for Kv1.3 helix formation
    Li Wei Tu
    Department of Physiology, University of Pennsylvania, Philadelphia, PA 19104 6085, USA
    J Mol Biol 396:1346-60. 2010
    ..These findings emerge from accessibility studies of a diversity of native transmembrane and linker sequences and may therefore be applicable to protein biogenesis in general...
  77. pmc Functional rescue of Kv4.3 channel tetramerization mutants by KChIP4a
    Ping Liang
    Department of Neurobiology, Neuroscience Research Institute, Peking University Health Science Center, Beijing, China
    Biophys J 98:2867-76. 2010
    ....
  78. pmc Structure of the gating ring from the human large-conductance Ca(2+)-gated K(+) channel
    Yunkun Wu
    Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9040, USA
    Nature 466:393-7. 2010
    ....
  79. pmc Effect of the I(to) activator NS5806 on cloned K(V)4 channels depends on the accessory protein KChIP2
    A Lundby
    The Danish National Research Foundation Centre for Cardiac Arrhythmia, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
    Br J Pharmacol 160:2028-44. 2010
    ..3 and various ancillary proteins, yet, the exact subunit composition of I(to) channels is still debated. Here we characterize the effect of NS5806 on heterologously expressed putative I(to) channel subunits and other potassium channels...
  80. pmc 2-Aminoethoxydiphenyl borate blocks electrical coupling and inhibits voltage-gated K+ channels in guinea pig arteriole cells
    Ke tao Ma
    Oregon Hearing Research Center, Oregon Health and Science University, Portland, Oregon 97239, USA
    Am J Physiol Heart Circ Physiol 300:H335-46. 2011
    ..They could be gap junction blockers superior to 18β-GA only when Ca(2+)-actived K(+) channel inhibition by the latter is a concern but inositol 1,4,5-trisphosphate receptor and voltage-gated K(+) channel inhibitions are not...
  81. doi Activation of voltage gated K⁺ channel Kv1.5 by β-catenin
    Carlos Munoz
    Department of Physiology, University of Tubingen, Gmelinstr 5, D 72076 Tubingen, Germany
    Biochem Biophys Res Commun 417:692-6. 2012
    ..5 requires the same protein domains that are required for association of β-catenin with cadherin. The experiments disclose a completely novel function of β-catenin, i.e. the regulation of Kv1.5 channel activity...
  82. doi Block of cloned Kv4.3 potassium channels by dapoxetine
    Imju Jeong
    Department of Physiology, Medical Research Center, College of Medicine, The Catholic University of Korea, 505 Banpo Dong, Socho gu, Seoul 137 701, Republic of Korea
    Neuropharmacology 62:2261-6. 2012
    ..3 currents by both preferentially binding to the open state of the channels and accelerating the closed-state inactivation. These data could provide insight into the mechanism underlying some of the therapeutic actions of this drug...
  83. pmc Delayed endosome-dependent CamKII and p38 kinase signaling in cardiomyocytes destabilizes Kv4.3 mRNA
    Chaoming Zhou
    Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Mol Cell Cardiol 52:971-7. 2012
    ..Hence, in addition to participating in channel traffic, cardiomyocyte endosomes control channel mRNA expression by mediating delayed oxidative CamKII-p38K signaling...
  84. doi Differential expression of potassium channels and abnormal conduction in experimental tachycardia-induced heart failure
    Christoph Birner
    Klinik und Poliklinik fur Innere Medizin II, Universitatsklinikum Regensburg, Franz Josef Strauss Allee 11, D 93055, Regensburg, Germany
    Naunyn Schmiedebergs Arch Pharmacol 385:473-80. 2012
    ..These molecular changes occur together with changes in cardiac function, geometry, conduction, and BNP expression and provide a functional basis for electrical vulnerability in heart failure...
  85. pmc Contribution of EAG to excitability and potassium currents in Drosophila larval motoneurons
    Subhashini Srinivasan
    Dept of Neuroscience, Univ of Arizona, Tucson, AZ 85721 0077, USA
    J Neurophysiol 107:2660-71. 2012
    ..Thus our results provide evidence that EAG represents a unique K(+) channel contributing to multiple K(+) currents in motoneurons helping to regulate excitability, consistent with previous observations in the Drosophila larval muscle...
  86. doi A novel KCND3 gain-of-function mutation associated with early-onset of persistent lone atrial fibrillation
    Morten Salling Olesen
    The Danish National Research Foundation Centre for Cardiac Arrhythmia, Copenhagen, Denmark
    Cardiovasc Res 98:488-95. 2013
    ..Here we aim to determine if mutations in KV4.3 or in the auxiliary subunit K(+) Channel-Interacting Protein (KChIP) 2 are associated with early-onset lone AF...
  87. doi Downregulation of KCNQ4 by Janus kinase 2
    Zohreh Hosseinzadeh
    Department of Physiology I, University of Tubingen, Tubingen, Germany
    J Membr Biol 246:335-41. 2013
    ..Thus, JAK2 apparently does not accelerate channel protein retrieval from the cell membrane. In conclusion, JAK2 downregulates KCNQ4 activity and thus counteracts K(+) exit, an effect which may contribute to cell volume regulation...
  88. doi A genome wide association study (GWAS) providing evidence of an association between common genetic variants and late radiotherapy toxicity
    Gillian C Barnett
    Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, UK University of Cambridge, Department of Oncology, Oncology Centre, Cambridge University Hospitals NHS Foundation Trust, UK Electronic address
    Radiother Oncol 111:178-85. 2014
    ..This study was designed to identify common single nucleotide polymorphisms (SNPs) associated with toxicity 2years after radiotherapy...
  89. pmc Pathogenesis of arrhythmias in a model of CKD
    Chia Hsiang Hsueh
    Krannert Institute of Cardiology and Division of Cardiology
    J Am Soc Nephrol 25:2812-21. 2014
    ..We conclude that cardiac ion channel and calcium handling are abnormal in CKD rats, leading to increased vulnerability to early afterdepolarization, triggered activity, and ventricular arrhythmias...
  90. pmc Effects of voltage-gated K+ channel on cell proliferation in multiple myeloma
    Wei Wang
    Department of Hematology, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Nangang District, Harbin 150001, China
    ScientificWorldJournal 2014:785140. 2014
    ..To study the effects and underlying mechanisms of voltage-gated K(+) channels on the proliferation of multiple myeloma cells...
  91. pmc Binding modes of two scorpion toxins to the voltage-gated potassium channel kv1.3 revealed from molecular dynamics
    Rong Chen
    Research School of Biology, Australian National University, Canberra, ACT 0200, Australia
    Toxins (Basel) 6:2149-61. 2014
    ..The dissociation constants calculated from the two binding modes of HgTx-Kv1.3 differ by approximately 20 fold, suggesting that the two modes are of similar energetics. ..
  92. doi Raloxifene inhibits cloned Kv4.3 channels in an estrogen receptor-independent manner
    Yun Ju Chae
    Department of Physiology, College of Medicine, The Catholic University of Korea, 222 Banpo daero, Seocho Gu, Seoul, 137 701, South Korea
    Pflugers Arch 467:1663-76. 2015
    ..Raloxifene inhibited Kv4.3 channels by interacting with their open state during depolarization and with the closed state at subthreshold potentials. This effect was not mediated via an estrogen receptor...
  93. pmc Amyloid-β(25-35) Modulates the Expression of GirK and KCNQ Channel Genes in the Hippocampus
    Jennifer Mayordomo-Cava
    University of Castilla La Mancha, Neurophysiology and Behavior Lab, CRIB, School of Medicine of Ciudad Real, Ciudad Real, Spain
    PLoS ONE 10:e0134385. 2015
    ..Our results provide evidence that Aβ can modulate the expression of these channels which could affect the hippocampal activity balance underlying learning and memory processes impaired in AD. ..
  94. doi Spontaneous inward currents reflecting oscillatory activation of Na⁺/Ca²⁺ exchangers in human embryonic stem cell-derived cardiomyocytes
    Seong Woo Choi
    Department of Physiology, Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Republic of Korea
    Pflugers Arch 468:609-22. 2016
    ..Since the hESC-CMs without SICs still showed spontaneous APs, the putative "Ca(2+) clock" would provide a redundant pacemaker or augmenting mechanism in hESC-CMs...
  95. pmc Role of Kv4.3 in Vibration-Induced Muscle Pain in the Rat
    Lindsay B Conner
    Department of Oral and Maxillofacial Surgery, University of California San Francisco, San Francisco, California
    J Pain 17:444-50. 2016
    ..3 messenger RNA itself induces muscle hyperalgesia in the rat. Our results suggest that attenuation in the expression of Kv4.3 may contribute to neuropathic pain in people affected by hand-arm vibration syndrome...
  96. pmc A peptide from the Drosophila Shaker K+ channel inhibits a voltage-gated K+ channel in basolateral membranes of Necturus enterocytes
    W P Dubinsky
    Department of Physiology and Cell Biology, University of Texas Medical School, Houston 77225
    Proc Natl Acad Sci U S A 89:1770-4. 1992
    ..BD and suggest that the molecular anatomy of the receptor at the inner face of the Necturus K+ channel with which the peptide interacts to bring about inhibition of that channel may be similar to that of the Shaker K+ channel...
  97. ncbi Regional contributions of Kv1.4, Kv4.2, and Kv4.3 to transient outward K+ current in rat ventricle
    A D Wickenden
    Department of Medicine, Centre for Cardiovascular Research, and The Toronto Hospital, University of Toronto, Toronto, Canada M5G 2C4
    Am J Physiol 276:H1599-607. 1999
    ..In conclusion, expression of Kv1.4, Kv4.2, and Kv4.3 differs between regions in rat hearts. Regionally specific differences in the genetic composition of Ito can account for the region-specific properties of this current...
  98. ncbi KChAP as a chaperone for specific K(+) channels
    Y A Kuryshev
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44109 1998, USA
    Am J Physiol Cell Physiol 278:C931-41. 2000
    ..1 and Kv4.3 from heart. We propose that KChAP is a chaperone for specific Kv channels and may have this function in cardiomyocytes where Kv4.3 produces the transient outward current, I(to)...
  99. pmc Molecular basis of functional voltage-gated K+ channel diversity in the mammalian myocardium
    J M Nerbonne
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, MO 63110, USA
    J Physiol 525:285-98. 2000
    ..e. Ito,f, Ito,s, IKr, IKs, IKur, IK,slow, etc.) in myocyardial cells...
  100. ncbi Localization of voltage-gated K(+) channels in squid giant axons
    J R Clay
    Laboratory of Neurophysiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurobiol 45:172-84. 2000
    ..We have also isolated an axoplasmic fraction containing approximately 150-nm-diameter vesicles that may transport K(+) channels back to the cell body...
  101. ncbi Alterations in potassium channel gene expression in atria of patients with persistent and paroxysmal atrial fibrillation: differential regulation of protein and mRNA levels for K+ channels
    B J Brundel
    Department of Cardiology, Thoraxcenter University Hospital Groningen, The Netherlands
    J Am Coll Cardiol 37:926-32. 2001
    ..Our purpose was to determine whether patients with persistent atrial fibrillation (AF) and patients with paroxysmal AF show alterations in potassium channel expression...

Research Grants59

  1. K and Ca Channels in Cardiac Hypertrophy and Failure
    Roger Hajjar; Fiscal Year: 2006
    ..abstract_text> ..
  2. Towards understanding the role of sumoylation in ion channel regulation
    Sindhu Rajan; Fiscal Year: 2011
    ..The Departments of Pediatrics, Neurobiology, Pharmacology and Physiology at the University of Chicago include an internationally recognized cadre of ion channel researchers. ..
  3. A New Family of Voltage-gated Potassium Channel Regulaory Subunits
    Steve A N Goldstein; Fiscal Year: 2011
    ..This revised application seeks to address concerns raised in the first review cycle. ..
  4. Functional Coupling between Ito and ICa in Cardiomyocytes
    Yanggan Wang; Fiscal Year: 2010
    ..The proposed study implicates a cell membrane potassium channel (Ito) in regulating the cellular calcium influx channel (ICa) function, which may decipher a new mechanism for this morbid disease. ..
  5. Markov Models of Potassium Channel Gating
    Randall L Rasmusson; Fiscal Year: 2012
    ..The long term goal is to predict clinical phenotype directly from channel defect. ..
  6. Voltage-gated K channels, microglia and HIV Dementia
    HUANGUI HANK XIONG; Fiscal Year: 2010
    ..If successful, these studies will provide a proper roadmap for expected efficacy of Kv channel antagonists in ameliorating brain injury. ..
  7. Seizure-Induced Plasticity of the Ia Current in the Entorhinal Cortex
    STEPHANIE CARLSON; Fiscal Year: 2010
    ..Also, Alzheimer's and schizophrenia affect EC neurons, so characterizing intrinsic currents in the neurons might be useful in the study of the diseases as well. ..
  8. SPERM PROGESTERONE RECEPTOR, K+ CHANNEL & PB EXPOSURE
    Asha Jacob; Fiscal Year: 1999
    ..They will determine the stage-specific expression of the human sperm K+ channel by in situ RT/PCR on human testes biopsy sections. ..
  9. MOLECULAR DETERMINANTS OF POTASSIUM CHANNEL DRUG BLOCK
    Dirk Snyders; Fiscal Year: 2003
    ....
  10. Kv4.3 Gating Current: Mechanisms Underlying Closed State Inactivation
    DONALD LEROY CAMPBELL; Fiscal Year: 2010
    ..The proposed research will provide new molecular and biophysical insights into basic mechanisms regulating Kv4 channels, and may thus provide the basis for development of more effective therapeutic treatments. ..
  11. The study of HERG-interacting proteins in C. elgans
    Christina Petersen; Fiscal Year: 2003
    ..elegans unc-103 gf background. These studies will improve our understanding of HERG and HERG/accessory protein interactions, and will facilitate drug design and aid in the prevention of life-threatening arrythmias. ..
  12. Reduced expression of 2 voltage-gated potassium ion-channels in prostate cancer.
    Naseema Hoosein; Fiscal Year: 2009
    ..The proposed studies will provide an understanding of Kv1.3 and HERG channel activity in human prostate cells and in prostate cancer progression, which is essential for their development as clinically useful tumor markers. ..
  13. Regulation of Cardiac Kv Channel Expression
    Edwin S Levitan; Fiscal Year: 2013
    ..Elucidating this pathway and its downstream effects on channels and other cardiac targets may lead to new therapies for treating heart failure. ..
  14. MOLECULAR BASIS FOR DRUG INDUCED CARDIOTOXICITY IN AIDS
    CRAIG CLARKSON; Fiscal Year: 2001
    ....
  15. Robert W Nickells; Fiscal Year: 2016
    ..Since we postulate that reversal of gene silencing is a critical component to reactivate ganglion cells, a complete understanding of the types of epigenetic changes associate with this phenomenon is essential. ..
  16. John R Giudicessi; Fiscal Year: 2014
    ..Further, it offers the possibility of unveiling novel biology through the exploration of still enigmatic pathology. ..
  17. Cardiac KCNE2 (MIRP1) Regulation by Estrogen and Cardiac Stress
    Mansoureh Eghbali; Fiscal Year: 2012
    ..The goal of this project is to gain insight in how estrogen may induce cardioprotection by regulating the activity of a gene that is exquisitely modulated by estrogen and that modifies cardiac excitability. ..
  18. Timothy J Jegla; Fiscal Year: 2014
    ..The research will provide valuable new insights into the control of neuronal firing and will provide a critical assessment of the value of Kv12.2 as a therapeutic target for antiepileptic drugs. ..
  19. Yuan Xiang Tao; Fiscal Year: 2014
    ..The proposed studies will provide major conceptual advances to our understanding of the molecular mechanism of neuropathic pain and might open a door for developing new strategies for treating neuropathic pain. ..
  20. MAURICIO S MONTAL; Fiscal Year: 2016
    ..The thrust of our program aims to establish structure-function relationships with a primary emphasis on the modular design of the transmembrane domain in voltage-gated channel proteins. ..
  21. Gary A Lorigan; Fiscal Year: 2016
    ..KCNE1 bind to the cytoplasmic domain of the KCNQ1 K+ channel? Which proposed structural model is correct for the E1/Q1 complex? Do disease-causing E1 or Q1 LQTS mutations alter the structure or binding mechanism of the E1/Q1 complex?! ..
  22. Diane M Papazian; Fiscal Year: 2014
    ....
  23. The Molecular Mechanisms of the GDNF-mediated Decrease in Alcohol Consumption
    Somayeh Ahmadiantehrani; Fiscal Year: 2010
    ..This research will contribute to the current knowledge base for the understanding and treatment of this and other drug addictions. ..
  24. Delayed Rectifier K Channel Biogenesis is Unveiled in Models of Long QT Syndrome
    Brian P Delisle; Fiscal Year: 2012
    ..1 and Kv11.1 traffic in distinct vesicular transport pathways. We anticipate that we will identify novel ways to increase the functional expression for trafficking deficient LQT1 and LQT2 mutations. ..
  25. Francis Valiyaveetil; Fiscal Year: 2016
    ..Further, the research is important as it will establish chemical synthesis as an important tool for understanding ion channel structure and function. ..
  26. STRUCTURE/FUNCTION STUDY OF A VOLTAGE GATED K CHANNEL
    Rolf Joho; Fiscal Year: 2000
    ..coli suitable for purification, functional characterization and reconstitution, and structural studies including X-ray crystallography and NMR spectroscopy. ..
  27. THYROID HORMONE AND CARDIAC SURGERY
    Irwin Klein; Fiscal Year: 2000
    ....
  28. Molecular Pathways of Heart K Channel Regulation
    Enrico Stefani; Fiscal Year: 2006
    ..abstract_text> ..
  29. REGULATION OF CARDIAC ION CHANNEL EXPRESSION
    EDWIN LEVITAN; Fiscal Year: 2004
    ..The understanding of such mechanisms may aid in the development of drugs to regulate channel expression with the goal of reducing the incidence of arrhythmias and sudden death. ..
  30. HORMONAL REGULATION OF MYOMETRIUM ION CHANNELS
    Enrico Stefani; Fiscal Year: 2003
    ..These studies will be relevant to design or improve therapeutic treatment(s) for pathological situations such as premature labor and dysmenorrhea. ..
  31. Potassium Channel Gene Therapy to Prevent Neuron Death
    Angela Lee; Fiscal Year: 2004
    ..Finally, we will examine the activity of these channels in healthy neurons and, if they are active, test their effects on normal learning and memory. ..
  32. ITO IN DOGS WITH INHERITED VENTRICULAR ARRHYTHMIAS
    Bruce Kornreich; Fiscal Year: 2005
    ..abstract_text> ..
  33. ASSEMBLY OF INWARD RECTIFIER K CHANNELS
    Kevin Ho; Fiscal Year: 1999
    ..Oligomerization and localization will be studied by sucrose gradient centrifugation, immunoprecipitation, immunoblotting, confocal microscopy, and functional expression in Xenopus oocytes and baculovirus-infected Sf-9 cells. ..
  34. K CHANNELS: STRUCTURE-FUNCTION RELATION AND MODULATION
    Gea Ny Tseng; Fiscal Year: 2006
    ..This structural information will be useful for the design and development of therapeutic agents targeting HERG and KCNE. ..
  35. ELECTRICAL INJURY--ELECTRO CONFORMATIONAL MEM PROTEINS
    Wei Chen; Fiscal Year: 1999
    ..It may be possible to design biochemical treatments and physical therapy to facilitate cell function recovery. ..
  36. Ion Channels in Motoneurons and Neuromuscular Synapses
    Enrico Stefani; Fiscal Year: 2003
    ..Specific antibodies for the a subunits and their regulatory b subunits will be used to determine their expression. These studies will provide basic information on synaptic physiology which is a key point to understand NMJ disorders ..
  37. Structure, Function and Regulation of Renal K Channels
    Gary Desir; Fiscal Year: 2005
    ..These studies should provide important information regarding the molecular structure of KCNA10 and its role in renal solute homeostasis. ..
  38. Protein interacting with Slo Family K+ Channels
    XIAOMING XIA; Fiscal Year: 2007
    ..A successful reverse RRS protocol can be widely applied to analyze signal transduction across cell membrane, as well as to study the mechanisms of diseases of public interests. [unreadable] [unreadable] [unreadable]..
  39. HYPERTENSION: CONTRIBUTION OF ARTERIAL WALL CHANGES
    Robert Cox; Fiscal Year: 2007
    ..These studies will define a novel therapeutic target for antihypertensive drug development based upon the mechanism(s) of Ca2+-Kv channel modulation. ..
  40. Regulation of Kv Channels by Anorexigens
    Bruce Pitt; Fiscal Year: 2007
    ..1 proteins, inhibition of Kv1.5 gene transcription and blockade of Kv currents at plasma membrane. ..
  41. REGULATION OF CARDIAC POTASSIUM CHANNEL GENE EXPRESSION
    Koichi Takimoto; Fiscal Year: 2002
    ..x gene expression independently of hypertrophy. Hence, this proposal is to test these possibilities using hypertension animal models and neonatal myocyte cultures. ..
  42. ION CHANNELS IN THE FUNCTIONING OF CORTICAL NEURONS
    JEANNE NERBONNE; Fiscal Year: 2005
    ..abstract_text> ..
  43. NEURONAL ELECTROPHYSIOLOGY IN HIV DEMENTIA
    HOWARD GENDELMAN; Fiscal Year: 2001
    ....
  44. CARDIAC GROWTH REGULATION
    Kaie Ojamaa; Fiscal Year: 2002
    ..End of Abstract) ..
  45. MECHANISMS OF PERMEATION IN INWARD RECTIFIER K+ CHANNELS
    Zhe Lu; Fiscal Year: 2002
    ..For example, G-protein gated inward-rectifier K+ channels mediate the regulation of heart rate by vagal nerve, and ATP-sensitive inward-rectifier K+ channels are important during cardiac ischemia. (End of Abstract) ..
  46. Molecular Dissection of Neuronal K+ Channel Function
    JEANNE NERBONNE; Fiscal Year: 2005
    ..Importantly, it seems likely that the multifaceted experimental approach developed here can also be applied to determine the molecular compositions and functional roles of voltage-gated (and other) K+ channels in other cells. ..
  47. Regulation of Kv2.1 Trafficking
    KRISTEN O CONNELL; Fiscal Year: 2005
    ..Therefore understanding of this process will contribute to our knowledge of how membrane excitability is regulated. ..
  48. Development of a new approach to study 3D structure of the sodium channel
    Isabelle Deschenes; Fiscal Year: 2008
    ..This information on the structure of the channel will be of tremendous help to understand how mutations in this channel are responsible for arrhythmias. [unreadable] [unreadable] [unreadable]..
  49. Molecular Biology of Calcuim Channel Gamma Subunits
    Daniel Burgess; Fiscal Year: 2006
    ....
  50. Thyroid Hormone Receptor Function in Cardiac Hypertrophy
    Kaie Ojamaa; Fiscal Year: 2006
    ..abstract_text> ..
  51. Training Program in Neurovirology
    HOWARD GENDELMAN; Fiscal Year: 2006
    ....
  52. Blood Brain Barrier Physiology and HIV Dementia
    HOWARD GENDELMAN; Fiscal Year: 2007
    ..The data acquired could provide new insights and therapeutic intervention strategies for monocyte BBB trafficking during progressive HIV-1 infection in brain tissue. ..
  53. Cell Biology of Cardiac Kv Channels
    KRISTEN O CONNELL; Fiscal Year: 2008
    ..Therefore, defects in ion channel localization may be an as-yet unrecognized cause of human cardiac disease, emphasizing the importance of understanding how these proteins are trafficked and localized in the heart. ..
  54. Advances in Renal Research: Human Diseases of Protein Processing
    David Ellison; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  55. Development and study of specific Kir channel inhibitors
    Zhe Lu; Fiscal Year: 2009
    ..abstract_text> ..
  56. REPOLARIZATION AND REMODELING IN THE MAMMALIAN HEART
    JEANNE NERBONNE; Fiscal Year: 2008
    ..In the long term, these insights should translate into more effective treatment strategies to reduce the risk of sudden death and the mortality and morbidity associated with myocardial hypertrophy and failure. ..