Genomes and Genes
Gene Symbol: Kv1.1
Description: potassium voltage-gated channel subfamily A member 1
Alias: AEMK, EA1, HBK1, HUK1, KV1.1, MBK1, MK1, RBK1, potassium voltage-gated channel subfamily A member 1, potassium channel, voltage gated shaker related subfamily A, member 1, potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia), voltage-gated K(+) channel HuKI, voltage-gated potassium channel HBK1, voltage-gated potassium channel subunit Kv1.1
Publications240 found, 100 shown here
- Voltage-gated K+ channels in rat small cerebral arteries: molecular identity of the functional channelsSulayma Albarwani
Department of Physiology, College of Medicine, Sultan Qaboos University, Al Khod, Sultanate of Oman
J Physiol 551:751-63. 2003..The findings of this study suggest that KV1.2/1.5 heterotetramers are preferentially expressed in rat cerebral VSMCs, and that these channels contribute to the resting membrane potential and diameter of rat small cerebral arteries...
- Functional coupling of intracellular calcium and inactivation of voltage-gated Kv1.1/Kvbeta1.1 A-type K+ channelsFlora Jow
Neuroscience Discovery Research, Wyeth Research, CN 8000, Princeton, NJ 08543, USA
Proc Natl Acad Sci U S A 101:15535-40. 2004....
- The human Kv1.1 channel is palmitoylated, modulating voltage sensing: Identification of a palmitoylation consensus sequenceRose A Gubitosi-Klug
Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 102:5964-8. 2005....
- Episodic ataxia/myokymia syndrome is associated with point mutations in the human potassium channel gene, KCNA1D L Browne
Department of Biochemistry and Molecular Biology, Oregon Health Sciences University, Portland 97201
Nat Genet 8:136-40. 1994..Mutation analysis of the KCNA1 coding region in these families identified four different missense point mutations present in the heterozygous state, indicating that EA/myokymia can result from mutations in this gene...
- A novel mutation in the human voltage-gated potassium channel gene (Kv1.1) associates with episodic ataxia type 1 and sometimes with partial epilepsyS M Zuberi
Department of Neurology and Child Development, Royal Hospital for Sick Children, Glasgow, UK
Brain 122:817-25. 1999Episodic ataxia type 1 (EA1) is a rare autosomal dominant disorder characterized by brief episodes of ataxia associated with continuous interattack myokymia. Point mutations in the human voltage-gated potassium channel (Kv1...
- Clinical, genetic, and expression studies of mutations in the potassium channel gene KCNA1 reveal new phenotypic variabilityL H Eunson
University Department of Clinical Neurology, Institute of Neurology University College of London, Queen Square, UK
Ann Neurol 48:647-56. 2000Episodic ataxia type 1 (EA1) is an autosomal dominant central nervous system potassium channelopathy characterized by brief attacks of cerebellar ataxia and continuous interictal myokymia...
- Nervous system targets of RNA editing identified by comparative genomicsBarry Hoopengardner
Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
Science 301:832-6. 2003..These results point to a pivotal role for RNA editing in nervous system function...
- Expanding the phenotype of potassium channelopathy: severe neuromyotonia and skeletal deformities without prominent Episodic AtaxiaM Kinali
Dubowitz Neuromuscular Centre, Hammersmith Hospital, Imperial College School of Medicine, London, UK
Neuromuscul Disord 14:689-93. 2004..His mother presented some years later with typical features of Episodic Ataxia type 1 (EA1), with episodes of ataxia lasting a few minutes provoked by exercise...
- Nongenetic factors influence severity of episodic ataxia type 1 in monozygotic twinsT D Graves
MRC Centre for Neuromuscular Diseases, UCL Institute of Neurology, University College London, Queen Square, London, United Kingdom
Neurology 75:367-72. 2010Episodic ataxia type 1 (EA1) is a monogenic channelopathy caused by mutations of the potassium channel gene KCNA1...
- Nerve excitability studies characterize Kv1.1 fast potassium channel dysfunction in patients with episodic ataxia type 1Susan E Tomlinson
Institute of Neurology, University College London, London WC1N 3BG, UK
Brain 133:3530-40. 2010..1 dysfunction in patients with episodic ataxia type 1. The simple 15 min test may be useful in diagnosis, since it can differentiate patients with episodic ataxia type 1 from normal controls with high sensitivity and specificity...
- Episodic ataxia and myokymia syndrome: a new mutation of potassium channel gene Kv1.1S Comu
Department of Pediatrics, University of Pittsburgh, PA, USA
Ann Neurol 40:684-7. 1996..This disease has been associated with point mutations in the potassium channel gene Kv1.1 (KCNA1), located at chromosome 12p13. Here, we describe a novel mutation within this gene in a newly diagnosed family...
- Three novel KCNA1 mutations in episodic ataxia type I familiesH Scheffer
Department of Medical Genetics, University of Groningen, The Netherlands
Hum Genet 102:464-6. 1998..By direct sequence analysis, a different missense mutation of the potassium channel gene (KCNA1) has been identified in three families with EA...
- Characterization of the outer pore region of the apamin-sensitive Ca2+-activated K+ channel rSK2Heike Jäger
Department of Applied Physiology, University of Ulm, Albert Einstein Allee 11, 89081 Ulm, Germany
Toxicon 43:951-60. 2004..From mutant cycle analysis of KTX position H34 and SK2 position V342G, S344E, and G348D we could deduce that KTX binds in a similar way to SK2 channel mutant pore than to the Kv1.1 pore...
- In vivo selection of Enterobacter aerogenes with reduced susceptibility to cefepime and carbapenems associated with decreased expression of a 40 kDa outer membrane protein and hyperproduction of AmpC beta-lactamaseFelipe Fernandez-Cuenca
Department of Microbiology, University of Seville, and University Hospital Virgen Macarena, Seville, Spain
Int J Antimicrob Agents 27:549-52. 2006..susceptibility to cefepime (FEP) and/or imipenem (IMP) in three consecutive isolates of Enterobacter aerogenes (Ea1, Ea2 and Ea3) cultured from bronchial aspirates of the same patient after treatment with ceftriaxone and FEP were ..
- Ataxias with autosomal, X-chromosomal or maternal inheritanceJosef Finsterer
Krankenanstalt Rudolfstiftung, Vienna, Austria, Europe
Can J Neurol Sci 36:409-28. 2009..spinocerebellar ataxias (SCA1-8, 10-15, 17-23, 25-30, and dentato-rubro-pallido-luysian atrophy), episodic ataxias (EA1-7), and autosomal dominant mitochondrial heredoataxias (Leigh syndrome, MIRAS, ADOAD, and AD-CPEO)...
- The abnormal occurrence and the differentiation-dependent distribution of N-acetyl and N-glycolyl species of the ganglioside GM2 in human germ cell tumors. A study with specific monoclonal antibodiesM Miyake
Department of Laboratory Medicine and Clinical Science, School of Medicine, Kyoto University, Japan
Cancer 65:499-505. 1990..specific monoclonal antibodies which can distinguish the molecular species of the sialic acid moiety: the antibody MK1-16 is specific for N-acetyl GM2, MK2-34 is specific for N-glycolyl GM2, and MK1-17 detects both N-acetyl and N-..
- Identification of mK1, a true tissue (glandular) kallikrein of mouse submandibular gland: tissue distribution and a comparison of kinin-releasing activity with other submandibular kallikreinsK Hosoi
Department of Oral Physiology, Meikai University School of Dentistry, Saitama
J Biochem 115:137-43. 1994..The present results revealed that the former proteinase F is identical to mK1, tissue/renal kallikrein, and confirmed its characteristics as a true kallikrein on the basis of its kinin-..
- Differences in substrate and inhibitor sequence specificity of human, mouse and rat tissue kallikreinsSandro E Fogaça
Department of Biophysics, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Rua Tres de Maio 100, São Paulo 04044 20, Brazil
Biochem J 380:775-81. 2004The kininogenase activities of mouse (mK1), rat (rK1) and human (hK1) tissue kallikreins were assayed with the bradykinin-containing synthetic peptides Abz-MTEMARRPPGFSPFRSVTVQNH2 (where Abz stands for o-aminobenzoyl) and Abz-..
- Methylamine and benzylamine induced hypophagia in mice: modulation by semicarbazide-sensitive benzylamine oxidase inhibitors and aODN towards Kv1.1 channelsR Pirisino
Department of Preclinical and Clinical Pharmacology, Viale Pieraccini, 6, 50134 Florence, Italy
Br J Pharmacol 134:880-6. 2001..1 blocking activity. Through a reduction of the endogenous breakdown of MET, Bz-SSAO inhibitors enhance the central pharmacological activity of this amine...
- The role of Kv1.2-containing potassium channels in serotonin-induced glutamate release from thalamocortical terminals in rat frontal cortexE K Lambe
Interdepartmental Neuroscience Program and Departments of Psychiatry and Pharmacology, Yale University School of Medicine, New Haven Connecticut 06508, USA
J Neurosci 21:9955-63. 2001..These results indicate that blockade of Kv1.2-containing potassium channels is part of the mechanism underlying 5-HT-induced glutamate release from thalamocortical terminals...
- Presynaptic rat Kv1.2 channels suppress synaptic terminal hyperexcitability following action potential invasionPaul D Dodson
Department of Cell Physiology and Pharmacology, University of Leicester, PO Box 138, Leicester LE1 9HN, UK
J Physiol 550:27-33. 2003..We conclude that Kv1.2 channels have a general presynaptic function in suppressing terminal hyperexcitability during the depolarising after-potential...
- Engineering-specific pharmacological binding sites for peptidyl inhibitors of potassium channels into KcsAChristian Legros
Institut für Neurale Signalverarbeitung, ZMNH, Universitat Hamburg, Martinistrasse 52, D 20246 Hamburg, Germany
Biochemistry 41:15369-75. 2002..X chimeras containing the subregion I of the corresponding mammalian Kv1.X channels. This innovative approach may facilitate the high-throughput screening of ligand libraries aimed at the discovery of novel potassium channel modulators...
- Role of disulfide bonds in the structure and potassium channel blocking activity of ShK toxinM W Pennington
Bachem Bioscience Inc, 3700 Horizon Drive, King of Prussia, Pennsylvania 19406, USA
Biochemistry 38:14549-58. 1999..The possible interactions of this analogue with the channel and the distinction between native secondary and tertiary structure on one hand and global topology imposed by the disulfide bridges on the other are discussed...
- New roles for renal potassium channelsCarsten A Wagner
Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
J Nephrol 23:5-8. 2010..Moreover, defects of 2 different potassium channels expressed on opposing membrane domains of the same cells cause distinct symptoms...
- A homeobox gene with potential developmental control function in the meristem of the conifer Picea abiesA Sundås-Larsson
Department of Physiological Botany, Uppsala University, Villavagen 6, S 752 36, Uppsala, Sweden
Proc Natl Acad Sci U S A 95:15118-22. 1998..In this report, we describe the first cDNA corresponding to a homeobox gene isolated from a gymnosperm, the HBK1 gene from the conifer Picea abies (L.) Karst (Norway spruce)...
- Involvement of kv1 potassium channels in spreading acidification and depression in the cerebellar cortexGang Chen
Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA
J Neurophysiol 94:1287-98. 2005..The dramatic effects of DTX-K suggest a possible connection between SAD and episodic ataxia type 1 (EA1), a Kv1.1 potassium channelopathy. The threshold for evoking SAD was significantly lowered in the Kv1...
- [Expression and properties of potassium channels in human mammary epithelial cell line MCF10A and its possible role in proliferation]Jia Liu
College of Life Science, Liaoning Normal University, Dalian, China
Sheng Li Xue Bao 62:203-9. 2010....
- Contribution of Kv1.2 voltage-gated potassium channel to D2 autoreceptor regulation of axonal dopamine overflowStephanie Fulton
Department of Pharmacology and Groupe de Recherche sur le Système Nerveux Central, Universite de Montreal, Quebec H3C 3J7, Canada
J Biol Chem 286:9360-72. 2011..2-containing channels in striatal tissue. These findings underline the contribution of Kv1.2 in the regulation of nigrostriatal DA release by the D2-AR and thereby offer a novel mechanism by which DA release is regulated...
- Differential distribution of Shaker-like and Shab-like K+-channel subunits in goldfish retina and retinal bipolar cellsS Yazulla
Department of Neurobiology and Behavior, University at Stony Brook, New York 11794 5230, USA
J Comp Neurol 396:131-40. 1998....
- Structure-activity relationships of the Kvbeta1 inactivation domain and its putative receptor probed using peptide analogs of voltage-gated potassium channel alpha- and beta-subunitsS J Lombardi
Wyeth Ayerst Research, CNS Disorders, Princeton, New Jersey 08543 8000, USA
J Biol Chem 273:30092-6. 1998..1 alpha subunit is the likely acceptor for the Kvbeta1 inactivation domain and provide information about residues that may underlie the protein-protein interactions responsible for beta-subunit mediated Kv channel inactivation...
- Additive and/or synergistic action (downregulation) of androgens and thyroid hormones on the cellular distribution and localization of a true tissue kallikrein, mK1, in the mouse submandibular glandShingo Kurabuchi
Dept of Histology, Nippon Dental University School of Dentistry at Tokyo, Fujimi 1 9 20, Chiyoda ku, Tokyo 102 8159, Japan
J Histochem Cytochem 52:1437-46. 2004..5alpha-dihydrotestosterone (DHT), 3,5,3'-triiodo-l-thyronine (T(3)), and dexamethasone (Dex) on the expression of mK1 in the granular convoluted tubule (GCT) cells of the submandibular gland (SMG) of hypophysectomized (Hypox) male ..
- Phylogenomic analyses of KCNA gene clusters in vertebrates: why do gene clusters stay intact?Simone Hoegg
Lehrstuhl fur Zoologie und Evolutionsbiologie, Department of Biology, University of Konstanz, 78457 Konstanz, Germany
BMC Evol Biol 7:139. 2007..Interestingly, this hypothesis does not appear to apply to the KCNA clusters, as too few conserved putative regulatory elements are retained...
- Kv1.1/1.2 channels are downstream effectors of nitric oxide on synaptic GABA release to preautonomic neurons in the paraventricular nucleusQ Yang
Department of Anesthesiology and Pain Medicine, Unit 110, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Neuroscience 149:315-27. 2007..These findings suggest that NO increases GABAergic input to PVN presympathetic neurons through a downstream mechanism involving the Kv1.1 and Kv1.2 channels at the nerve terminals...
- Recent advances in the genetics of recurrent vertigo and vestibulopathyJoanna C Jen
Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095 1769, USA
Curr Opin Neurol 21:3-7. 2008..To focus on recent advances in the genetics of recurrent vertigo, with an overview on episodic ataxia, benign recurrent vertigo (mainly migraine-associated vertigo), bilateral vestibulopathy, and Ménière's disease...
- Sensitivity of native and cloned hippocampal delayed-rectifier potassium channels to verapamilM Madeja
Institut fur Physiologie, Munster, Germany
Neuropharmacology 39:202-10. 2000..1 channel, 98 micromol/l for the Kv1.2 channel, 12 micromol/l for the Kv1.3 channel, 226 micromol/l for the Kv2.1 channel, 6 micromol/l for the Kv3.1 channel and 11 micromol/l for the Kv3.2 channel...
- Truncation of the Shaker-like voltage-gated potassium channel, Kv1.1, causes megencephalySusanna Petersson
Neurogenetic Unit, Department of Molecular Medicine, CMM, L8 00, Karolinska Institutet, 171 76 Stockholm, Sweden
Eur J Neurosci 18:3231-40. 2003..However, in contrast to the commonly demonstrated epilepsy-induced neurodegeneration, we find that the mceph mutation leads to seizures with a concomitant increase in brain size, without overt neural atrophy...
- A novel beta subunit increases rate of inactivation of specific voltage-gated potassium channel alpha subunitsM J Morales
Department of Pharmacology, Duke University Medical Center, Durham, North Carolina 27710
J Biol Chem 270:6272-7. 1995..This study shows that voltage-gated K+ channel beta subunits are present outside the central nervous system, and that at least one member of this family selectively modulates inactivation of K+ channel alpha subunits...
- Glycosylation affects rat Kv1.1 potassium channel gating by a combined surface potential and cooperative subunit interaction mechanismItaru Watanabe
Department of Biological Sciences, Fordham University, Bronx, NY 10458, USA
J Physiol 550:51-66. 2003..Differences in glycosylation pattern among closely related channels may contribute to their functional differences and affect their physiological roles...
- Lack of potassium channel induces proliferation and survival causing increased neurogenesis and two-fold hippocampus enlargementMalin Almgren
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
Hippocampus 17:292-304. 2007..This phenotype is a result, at least in DG, from increased proliferation, neurogenesis, and enhanced general hippocampal cell survival...
- The investigation of interactions of kappa-Hefutoxin1 with the voltage-gated potassium channels: a computational simulationM Zarrabi
Department of Biophysics, Faculty of Science, Tarbiat Modares University, Tehran, Iran
Proteins 71:1441-9. 2008....
- Arrangement of Kv1 alpha subunits dictates sensitivity to tetraethylammoniumAhmed Al-Sabi
International Centre for Neurotherapeutics, Dublin City University, Dublin 9, Ireland
J Gen Physiol 136:273-82. 2010..These collective findings indicate that assembly of alpha subunits can be directed by this optimized concatenation, and that subunit arrangement in heteromeric Kv channels affects TEA affinity...
- Differences in androgen-dependent induction of mk1, true tissue kallikrein in C3H/HeN and ICR mouse submandibular glandK Kurihara
Department of Oral Physiology, Meikai University School of Dentistry, Sakado, Saitama, Japan
Horm Metab Res 31:370-4. 1999Androgen-dependent induction of mk1, true tissue kallikrein, in submandibular gland was studied in C3H/HeN and ICR mice and their F1 progeny...
- Amino-terminal determinants of U-type inactivation of voltage-gated K+ channelsHarley T Kurata
Department of Physiology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
J Biol Chem 277:29045-53. 2002..1. These data suggest that intersubunit T1 domain interactions influence U-type inactivation in Kv1 channels, and suggest a generalized influence of the T1 domain on U-type inactivation between Kv channel subfamilies...
- Respiratory syncytial virus, human bocavirus and rhinovirus bronchiolitis in infantsF Midulla
Department of Pediatrics, Sapienza University of Rome, Viale Regina Elena 324, 00165 Rome, Italy
Arch Dis Child 95:35-41. 2010..To investigate the prevalence of 14 viruses in infants with bronchiolitis and to study demographic and clinical differences in those with respiratory syncytial virus (RSV), human bocavirus (hBoV) and rhinovirus (RV) infection...
- The distribution of ganglioside-like moieties in peripheral nervesK A Sheikh
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Brain 122:449-60. 1999..1 and Kv1.5 and are thus not likely carried by these ion channels. In contrast with Gal(beta1-3)GalNAc, GT1b-like moieties are restricted to the axolemma...
- Estrogen-dependent expression of the tissue kallikrein gene (Klk1) in the mouse uterus and its implications for endometrial tissue growthSanath Rajapakse
Division of Biological Sciences, Graduate School of Science, Hokkaido University, Sapporo, Japan
Mol Reprod Dev 74:1053-63. 2007Tissue kallikrein mK1 is a serine protease involved in the generation of bioactive kinins for normal cardiac and arterial function in the mouse...
- Identification of amino acids in the pore region of Kv1.2 potassium channel that regulate its glycosylation and cell surface expressionIku Utsunomiya
Department of Pharmacotherapeutics, Showa Pharmaceutical University, Tokyo, Japan
J Neurochem 112:913-23. 2010..2 is regulated by specific amino acids in the pore region in a similar manner to Kv1.1 and Kv1.4, and that the cell surface expression of Kv1.2, a channel intermediate between Kv1.1 and Kv1.4, can be attributed to these specific residues...
- A family of three mouse potassium channel genes with intronless coding regionsK G Chandy
Department of Medicine, University of California, Irvine 92717
Science 247:973-5. 1990..channels in mammalian cells, mouse genomic clones have been isolated with a potassium channel complementary DNA, MBK1, that is homologous to the Drosophila potassium channel gene, Shaker...
- Deranged Kv channel regulation in fibroblasts from mice lacking the serum and glucocorticoid inducible kinase SGK1Ekaterina Shumilina
Department of Physiology, University of Tuebingen, Germany
J Cell Physiol 204:87-98. 2005..In conclusion, lack of SGK1 does not abrogate Kv channel activity but abolishes regulation of those channels by serum, glucocorticoids and IGF-1, an effect influencing capacitative Ca(2+) entry...
- Fast apoptosis and erythroid differentiation induced by imatinib mesylate in JURL-MK1 cellsKaterina Kuzelova
Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20 Prague 2, Czech Republic
J Cell Biochem 95:268-80. 2005We compare the effects of Imatinib mesylate (Glivec) on chronic myeloid leukemia derived cell lines K562 and JURL-MK1. In both cell lines, the cell cycle arrests in G(1)/G(0) phase within 24 h after the addition of 1 microM Imatinib...
- Neuromyotonia and limbic encephalitis sera target mature Shaker-type K+ channels: subunit specificity correlates with clinical manifestationsKleopas A Kleopa
Department of Clinical Neurosciences, Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus, PA, USA
Brain 129:1570-84. 2006..Although more than one type of antibody is often detectable in individual sera, higher affinity for certain subunits or subunit combinations may determine the range of clinical manifestations...
- Real time detection of anthrax spores using highly specific anti-EA1 recombinant antibodies produced by competitive panningTracey E Love
Detection Department, Dstl Porton Down, Salisbury, Wiltshire, SP4 OJQ, United Kingdom
J Immunol Methods 334:1-10. 2008..The aim was to produce single chain antibodies (scFvs) to EA1, a Bacillus anthracis S-layer protein that is also present, although not identical, in related to Bacillus species...
- Kv1.1 and Kv1.3 channels contribute to the delayed-rectifying K+ conductance in rat choroid plexus epithelial cellsTracey Speake
School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
Am J Physiol Cell Physiol 286:C611-20. 2004..In conclusion, Kv1.1 and Kv1.3 channels make a significant contribution to K+ efflux at the apical membrane of the choroid plexus...
- Kv1.1 and Kv1.3 channels contribute to the degeneration of retinal ganglion cells after optic nerve transection in vivoP D Koeberle
Division of Anatomy, Department of Surgery, University of Toronto, Ontario, Canada
Cell Death Differ 17:134-44. 2010..Kv1.1 depletion increased the antiapoptotic gene, Bcl-X(L), whereas Kv1.3 depletion reduced the proapoptotic genes, caspase-3, caspase-9 and Bad...
- Both N- and C-terminal regions contribute to the assembly and functional expression of homo- and heteromultimeric voltage-gated K+ channelsW F Hopkins
Geriatric Research Education and Clinical Center, Veterans Affairs Medical Center, Seattle, Washington 98108
J Neurosci 14:1385-93. 1994..1 (MBK1), a mouse Shaker-like K+ channel...
- Immunological identification of the Shaker-related Kv1.3 potassium channel protein in T and B lymphocytes, and detection of related proteins in files and yeastR H Spencer
Department of Microbiology and Molecular Genetics, University of California, Irvine 92717
Biochem Biophys Res Commun 191:201-6. 1993..Abs which recognize these shared epitopes could serve for the identification and biochemical characterization of Shaker-related proteins in diverse organisms...
- Peptidyl inhibitors of shaker-type Kv1 channels elicit twitches in guinea pig ileum by blocking kv1.1 at enteric nervous system and enhancing acetylcholine releaseG Suarez-Kurtz
Coordenação de Pesquisa, Instituto Nacional de Cancer, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
J Pharmacol Exp Ther 289:1517-22. 1999..1. The data taken together suggest that high-affinity blockade of Kv1.1 underlies the ability of MgTX, kaliotoxin, agitoxin-1, agitoxin-2, alpha-dendrotoxin, and stichodactylatoxin to elicit TTX-sensitive twitches in guinea pig ileum...
- Maurotoxin and the Kv1.1 channel: voltage-dependent binding upon enantiomerization of the scorpion toxin disulfide bridge Cys31-Cys34C Lecomte
Laboratoire de Biochimie, CNRS UMR 6560, IFR Jean Roche, Faculte de Medecine Nord, Marseille, France
J Pept Res 55:246-54. 2000..3, and to a lesser extent, Kv1.2 channels and it may contribute to the stabilization and strength of the interaction between the toxin and the Kv1.1 channel...
- Subunit composition and novel localization of K+ channels in spinal cordM N Rasband
Department of Biochemistry and Cell Biology and Institute for Cell and Developmental Biology, State University of New York, Stony Brook, NY 11794, USA
J Comp Neurol 429:166-76. 2001..Moreover, the conservation of these characteristics between human, rat, and bovine nodes of Ranvier suggests an essential role for this defined channel complex in spinal cord function...
- Comparison of exhaust emissions from Swedish environmental classified diesel fuel (MK1) and European Program on Emissions, Fuels and Engine Technologies (EPEFE) reference fuel: a chemical and biological characterization, with viewpoints on cancer riskR Westerholm
Department of Analytical Chemistry, Arrhenius Laboratory, Stockholm University, S 106 91 Stockholm, Sweden
Environ Sci Technol 35:1748-54. 2001..of the present investigation was to compare the most stringent, environmentally classified Swedish diesel fuel (MK1) to the reference diesel fuel used in the "European Program on Emissions, Fuels and Engine Technologies" (EPEFE) ..
- Interleukin-4 downregulates nuclear factor-erythroid 2 (NF-E2) expression in primary megakaryocytes and in megakaryoblastic cell linesL Catani
Istituto di Ematologia e Oncologia Medica L e A Seragnoli, University of Bologna Italy
Stem Cells 19:339-47. 2001..factor-beta1 (TGF-beta1) on the expression of NF-E2 transcription factor in megakaryoblastic cell lines (Hel and MK1) and in normal CD34-derived megakaryocytic cells...
- Differential Ca(2+)responses induced by thrombin and thrombin-receptor agonist peptides in HSY-EA1 cellsAkihiko Tanimura
Department of Dental Pharmacology, School of Dentistry, Health Sciences University of Hokkaido, Ishikari Tobetsu, Hokkaido 061 0293, Japan
Cell Biol Int 27:1017-23. 2003..desensitized by comparing the effect of thrombin and the soluble agonist peptide SFLLRN on Ca(2+)responses in HSY-EA1 cells...
- Molecular docking of the scorpion toxin Tc1 to the structural model of the voltage-gated potassium channel Kv1.1 from human Homo sapiensHsuan Liang Liu
Department of Chemical Engineering, Graduate Institute of Biotechnology, National Taipei University of Technology, No 1 Sec 3 Chung Hsiao E Rd, Taipei, Taiwan 10608
J Biomol Struct Dyn 21:639-50. 2004..1. Furthermore, surface complementarity of the outer vestibules of the channels to the Tc1 spatial conformations also plays an important role in stabilizing both the Tc1/KcsA and Tc1/Kv1.1 complexes...
- Age-related changes in the distribution of Kv1.1 and Kv3.1 in rat cochlear nucleiDo Kwang Jung
Department of Otolaryngology Head and Neck Surgery, College of Medicine, Chung Ang University, 221 Heukseok dong, Dongjak Gu, Seoul 156 756, Korea
Neurol Res 27:436-40. 2005..1 and Kv3.1 in the auditory brainstem of adult and aged rats...
- The D-diastereomer of ShK toxin selectively blocks voltage-gated K+ channels and inhibits T lymphocyte proliferationChristine Beeton
Department of Physiology and Biophysics, University of California, California, Irvine, 92697 4560, USA
J Biol Chem 283:988-97. 2008..Being resistant to proteolysis and nonantigenic, this analogue should be useful in K(+) channel studies; all-d analogues with improved Kv1.3 potency and specificity may have therapeutic advantages...
- Determination of editors at the novel A-to-I editing positionsYoshinori Nishimoto
Department of Neurology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Neurosci Res 61:201-6. 2008..Because ADAR2 underactivity may be a causative molecular change of death of motor neurons in sporadic amyotrophic lateral sclerosis (ALS), this newly identified ADAR2-mediated editing position may become a useful tool for ALS research...
- Regulation of intrinsic excitability in hippocampal neurons by activity-dependent modulation of the KV2.1 potassium channelDurga P Mohapatra
Department of Neurobiology, Physiology and Behavior, College of Biological Sciences, University of California, Davis, CA 95616 8519, USA
Channels (Austin) 3:46-56. 2009..1-containing channels. These studies together demonstrate a specific contribution of modulation of KV2.1 channels in the activity-dependent regulation of intrinsic neuronal excitability...
- Down-regulation of delayed rectifier K+ channels in the hippocampus of seizure sensitive gerbilsSang Moo Lee
Department of Neurology, College of Medicine, Hallym University, Chunchon 200 702, Kangwon Do, South Korea
Brain Res Bull 80:433-42. 2009..1, Kv1.2, Kv1.5, Kv1.6, Kv2.1 and Kv3.1-2), not A-type K(+) channels (Kv1.4, Kv3.4 and Kv4.x), may be down-regulated in the SS gerbil hippocampus, as compared to SR gerbils...
- Clinical neurophysiology of the episodic ataxias: insights into ion channel dysfunction in vivoSusan E Tomlinson
Institute of Clinical Neurosciences, Royal Prince Alfred Hospital and University of Sydney, Sydney, Australia
Clin Neurophysiol 120:1768-76. 2009..The clinical, genetic and electrophysiological features of EA1 and EA2 are outlined, and a protocol for the assessment of these patients is proposed.
- Increase of Kv3.1b expression in avian auditory brainstem neurons correlates with synaptogenesis in vivo and in vitroThomas Kuenzel
Institute of Biology 2, RWTH Aachen University, Aachen, Germany
Brain Res 1302:64-75. 2009....
- Molecular remodeling of potassium channels in fibroblasts from centenarians: a marker of longevity?Isabella Zironi
Department of Physics, University of Bologna, 40127 Bologna, Italy
Mech Ageing Dev 131:674-81. 2010..The maintenance of "young" K(+) currents and the peculiar age-related remodeling of K(+) channel subtypes in centenarian's DF is likely associated with successful aging and might provide a predictive marker of longevity...
- Protein 4.1B contributes to the organization of peripheral myelinated axonsCarmen Cifuentes-Diaz
INSERM, UMR S 839, Paris, France
PLoS ONE 6:e25043. 2011..Thus, our results show that in myelinated axons 4.1B contributes to the stabilization of membrane proteins at paranodes, to the clustering of juxtaparanodal proteins, and to the regulation of the internodal axon caliber...
- A-to-I RNA editing modulates the pharmacology of neuronal ion channels and receptorsA K Streit
Institute for Physiology and Pathophysiology, Vegetative Physiology, Philipps University Marburg, Marburg, 35037, Germany
Biochemistry (Mosc) 76:890-9. 2011..1 channel, and the 5-HT(2C) receptor. Our review summarizes that RNA editing of these proteins does not only change protein function, but also the pharmacology and presumably the drug therapy in human diseases...
- Mechanism of accelerated current decay caused by an episodic ataxia type-1-associated mutant in a potassium channel poreChristian J Peters
Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
J Neurosci 31:17449-59. 2011....
- Affinity and selectivity of ShK toxin for the Kv1 potassium channels from free energy simulationsM Harunur Rashid
School of Physics, University of Sydney, New South Wales 2006, Australia
J Phys Chem B 116:4812-22. 2012..The insights gained on Kv1.x-ShK binding modes will be valuable in the development of new ShK analogues with better selectivity properties. ..
- Secretion genes as determinants of Bacillus anthracis chain lengthSao Mai Nguyen-Mau
Howard Taylor Ricketts Laboratory, Argonne National Laboratory, Argonne, Illinois, USA
J Bacteriol 194:3841-50. 2012..Both secA2 and slaP are required for the efficient secretion of Sap and EA1 (Eag), the two S-layer proteins of B...
- Expression of the voltage-gated potassium channel subunit Kv1.1 in embryonic zebrafish Mauthner cellsDaniel L Brewster
Department of Biological Sciences, Biological Sciences Building, University of Alberta, Edmonton, Alberta, Canada T6G 2E9
Neurosci Lett 539:54-9. 2013..Together, these results suggest that Mauthner cells express potassium channels that contain Kv1.1 subunits, which might contribute to cell firing...
- Spatio-temporal patterns of genetic change amongst populations of cassava Bemisia tabaci whiteflies driving virus pandemics in East and Central AfricaJames P Legg
International Institute of Tropical Agriculture IITA, PO Box 34441, Dar es Salaam, Tanzania Electronic address
Virus Res 186:61-75. 2014..Eight phylogenetically distinct groups were identified, including one, designated herein as 'East Africa 1' (EA1), not previously described. The three most frequently occurring groups comprised >95% of all samples...
- [The reasons why 13 MK1 attachment were re-fabricated and some methods for improvement]Zhi hong Wu
Department of Prosthodontics, Affiliated Stomatological Hospital of Jiujiang University Jiujiang 332000, Jiangxi
Shanghai Kou Qiang Yi Xue 22:715-7. 2013To investigate the reasons why 13 MK1 attachment were re-fabricated and to suggest some improvement methods.
- Using constellation pharmacology to define comprehensively a somatosensory neuronal subclassRussell W Teichert
Department of Biology, University of Utah, Salt Lake City, UT 84112
Proc Natl Acad Sci U S A 111:2319-24. 2014..The broad implications of this study are that it is now feasible to track changes in receptor and ion-channel expression in individual neuronal subclasses as a function of development, learning, disease, or aging. ..
- Selective Loss of Presynaptic Potassium Channel Clusters at the Cerebellar Basket Cell Terminal Pinceau in Adam11 Mutants Reveals Their Role in Ephaptic Control of Purkinje Cell FiringMatthew J Kole
Developmental Neurogenetics Laboratory, Department of Neurology
J Neurosci 35:11433-44. 2015..Our findings identify a critical role for presynaptic K(+) channels at the pinceau in ephaptic control over the speed and stability of spike rate coding at the Purkinje cell AIS in mice...
- Scorpion Potassium Channel-blocking Defensin Highlights a Functional Link with NeurotoxinLanxia Meng
From the State Key Laboratory of Virology, College of Life Sciences and
J Biol Chem 291:7097-106. 2016..These findings not only demonstrate that defensins from invertebrate animals are a novel type of potassium channel blockers but also provide evidence of a functional link between defensins and neurotoxins...
- Pore size matters for potassium channel conductanceDavid Naranjo
Centro Interdisciplinario de Neurociencia de Valparaíso, Universidad de Valparaiso, Playa Ancha, Valparaíso 2360103, Chile
J Gen Physiol 148:277-91. 2016..Here we raise the idea that the physical dimensions of the hydrophobic internal vestibule limit ion transport in K(+) channels, accounting for their diversity in unitary conductance. ..
- Genomic organization, nucleotide sequence, biophysical properties, and localization of the voltage-gated K+ channel gene KCNA4/Kv1.4 to mouse chromosome 2/human 11p14 and mapping of KCNC1/Kv3.1 to mouse 7/human 11p14.3-p15.2 and KCNA1/Kv1.1 to human 12p13R S Wymore
Department of Physiology, University of California, Irvine 92717
Genomics 20:191-202. 1994..1, lies approximately 1.8 cM from the Myod-1 gene on mouse chromosome 7, and in situ hybridization localizes KCNC1/hKv3.1 to the homologous region on human chromosome 11p14.3-p15.2. A third gene, KCNA1/hKv1.1, was mapped to human 12p13...
- Nodes, paranodes, and incisures: from form to functionS S Scherer
Department of Neurology, University of Pennsylvania Medical Center, Philadelphia 19104, USA
Ann N Y Acad Sci 883:131-42. 1999..Reflexive gap junctions, comprising connexin32 and at least one other connexin protein, form a radial pathway for the diffusion of ions and small molecules directly across the myelin sheath...
- KChAP as a chaperone for specific K(+) channelsY A Kuryshev
Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44109 1998, USA
Am J Physiol Cell Physiol 278:C931-41. 2000..1 and Kv4.3 from heart. We propose that KChAP is a chaperone for specific Kv channels and may have this function in cardiomyocytes where Kv4.3 produces the transient outward current, I(to)...
- Heteromeric Kv1 potassium channel expression: amino acid determinants involved in processing and trafficking to the cell surfaceJing Zhu
Department of Biological Sciences, Fordham University, Bronx, New York 10458, USA
J Biol Chem 278:25558-67. 2003..Thus a neuron may regulate its cell surface K+ channel protein levels by different Kv1 subfamily homomeric and heteromeric combinations that affect intracellular retention characteristics and protein stability...
- Structural and functional alterations of spinal cord axons in adult Long Evans Shaker (LES) dysmyelinated ratsEftekhar Eftekharpour
Division of Cell and Molecular Biology, Toronto Western Research Institute, Krembil Neuroscience Center, McMaster University, Hamilton, Canada
Exp Neurol 193:334-49. 2005..Further understanding of these issues in this model could provide critical insights for neurological disorders characterized by demyelination...
- Episodic ataxia type 1 mutations in the KCNA1 gene impair the fast inactivation properties of the human potassium channels Kv1.4-1.1/Kvbeta1.1 and Kv1.4-1.1/Kvbeta1.2Paola Imbrici
University of Perugia School of Medicine, Department of Internal Medicine, Section of Human Physiology, Via del Giochetto, I 06126 Perugia, Italy
Eur J Neurosci 24:3073-83. 2006Episodic ataxia type 1 (EA1) is an autosomal dominant neurological disorder characterized by constant muscle rippling movements (myokymia) and episodic attacks of ataxia...
- The voltage-gated K+ channel subunit Kv1.1 links kidney and brainDavid H Ellison
Division of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
J Clin Invest 119:763-6. 2009..Mechanisms by which the apical voltage is generated and howKv1.1 fits within this context are discussed herein...
- Mutually exclusive distribution of the sap and eag S-layer genes and the lytB/lytA cell wall hydrolase genes in Bacillus thuringiensisBrahim Soufiane
Agriculture and Agri Food Canada, Research and Development Centre, 430 Gouin Blvd, Saint Jean sur Richelieu, QC, Canada
Antonie Van Leeuwenhoek 100:349-64. 2011..not of the expected crystal (Cry) proteins but rather of the surface layer proteins (SLP) Sap (encoded by sap) and EA1 (encoded by eag), respectively. Whether the presence of the sap and eag genes is restricted to these two B...
- Clinical, genetic, neurophysiological and functional study of new mutations in episodic ataxia type 1Susan Elizabeth Tomlinson
MRC Centre for Neuromuscular Disease, National Hospital for Neurology and Neurosurgery, London, UK
J Neurol Neurosurg Psychiatry 84:1107-12. 2013Heterozygous mutations in KCNA1 cause episodic ataxia type 1 (EA1), an ion channel disorder characterised by brief paroxysms of cerebellar dysfunction and persistent neuromyotonia...
- Real-time analysis of imatinib- and dasatinib-induced effects on chronic myelogenous leukemia cell interaction with fibronectinAdam Obr
Department of Cellular Biochemistry, Institute of Hematology and Blood Transfusion, Prague, Czech Republic Department of Cell Biology, Faculty of Science, Charles University in Prague, Prague, Czech Republic
PLoS ONE 9:e107367. 2014..real-time monitoring of microimpedance, we studied in detail the kinetics of interaction of human CML cells (JURL-MK1, MOLM-7) and of control BCR-ABL-negative leukemia cells (HEL, JURKAT) with fibronectin-coated surface...
- Advances on genetic rat models of epilepsyTadao Serikawa
Graduate School of Medicine, Kyoto University, Sakyo ku 606 8501 Laboratory of Pharmacology, Osaka University of Pharmaceutical Sciences, Takatsuki 569 1094, Japan
Exp Anim 64:1-7. 2015..In addition, we have established episodic ataxia type 1 (EA1) model rats with a Kcna1 missense mutation derived from the ENU-induced rat mutant stock, and identified a Cacna1a ..
- Production and cell surface display of recombinant anthrax protective antigen on the surface layer of attenuated Bacillus anthracisYan Chun Wang
State Key Laboratory of Pathogens and Biosecurity, Beijing Institute of Biotechnology, 20 Dongdajie Street, Fengtai District, Beijing, 100071, China
World J Microbiol Biotechnol 31:345-52. 2015..a translational fusion harboring the DNA fragments encoding the cell wall-targeting domain of the S-layer protein EA1 and the anthrax PA. Crerecombinase action at the loxP sites excised the antibiotic marker...
- Assembly of juxtaparanodes in myelinating DRG culture: Differential clustering of the Kv1/Caspr2 complex and scaffolding protein 4.1BBruno Hivert
Aix Marseille Universite, CNRS, Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille UMR7286, Marseille, France
Glia 64:840-52. 2016..Thus, developing an adapted culture paradigm, we provide new insights into the dynamic and differential distribution of Kv1 channels and associated proteins during myelination...
- Expression and chromosomal localization of a lymphocyte K+ channel geneS Grissmer
Department of Physiology and Biophysics, University of California, Irvine 92715
Proc Natl Acad Sci U S A 87:9411-5. 1990We recently isolated a family of three closely related mouse K+ channel genes (MK1, MK2, and MK3) with coding regions contained in single uninterrupted exons...
- The brain Kv1.1 potassium channel: in vitro and in vivo studies on subunit assembly and posttranslational processingK K Deal
Department of Pharmacology, Vanderbilt Medical School, Nashville, Tennessee 37232
J Neurosci 14:1666-76. 1994..Together these results suggest (1) heteromeric assembly of Shaker-like channels is cotranslational, and (2) N207 glycosylation of Kv1.1 occurs but is not required for subunit assembly, transport, or function...
- Molecular cloning of a glibenclamide-sensitive, voltage-gated potassium channel expressed in rabbit kidneyX Yao
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA
J Clin Invest 97:2525-33. 1996..We conclude that rabKv1.3 is a novel member of the Shaker superfamily that may play an important role in renal potassium transport...
- A gene for autosomal dominant paroxysmal choreoathetosis/spasticity (CSE) maps to the vicinity of a potassium channel gene cluster on chromosome 1p, probably within 2 cM between D1S443 and D1S197G Auburger
Department of Neurology, University Hospital, Dusseldorf, Germany
Genomics 31:90-4. 1996..2 at a recombination fraction theta = 0 to D1S451/421/447/GGAT4C11. Crossing-over events in 9 patients and 4 unaffected offspring suggested a probable assignment of the gene to a region of 2 cM between D1S443 and D1S197...
- Association and colocalization of the Kvbeta1 and Kvbeta2 beta-subunits with Kv1 alpha-subunits in mammalian brain K+ channel complexesK J Rhodes
Central Nervous System Disorders, Wyeth Ayerst Research, Princeton, New Jersey 08543, USA
J Neurosci 17:8246-58. 1997....
- Role of glycosylation in voltage-gated potassium channelsDesiree A Thayer; Fiscal Year: 2010....
- KEITH ALAN VOSSEL; Fiscal Year: 2015..The mentoring and research experience described in this proposal will facilitate the candidate's goal of developing a strong independent research career. ..
- Behavioral Measures of Temporal Resolution in Mice With or Without Kv1.1 SubunitsMicheal L Dent; Fiscal Year: 2010..It is unknown, however, how this affects the 'real world'listening situation of these animals, so this will be determined here. ..
- DIFFERENTIATION OF NEURONAL SIGNALING MECHANISMSMICHAEL BARISH; Fiscal Year: 2000....
- Excitability mechanisms of neurocardiac regulationALBERT E GLASSCOCK; Fiscal Year: 2012....
- ALBERT E GLASSCOCK; Fiscal Year: 2015..abstract_text> ..
- Functional roles of Kv1 channels in inhibitory cortical interneuronsBrian D Clark; Fiscal Year: 2010..This research focuses on the role of these proteins in inhibitory cells in the cortex and is a contribution to understanding the pathophysiology of epilepsy in humans. ..
- Targeting of Voltage-gated K+ Channels to Lipid RaftsMichael Tamkun; Fiscal Year: 2004..1-containing lipid rafts from brain. This proposed research examines a new area in Kv channel research that will have important implications in multiple tissue systems. ..
- A Mouse Model of Mammalian Shaker Channel RNA EditingTarun Bhalla; Fiscal Year: 2006..Episodic Ataxia / Myokymia Syndrome Type 1 (EA1) is the only human ataxia known to be caused by dysfunction of a K+ channel...
- REGULATORY MECHANISMS OF CARDIAC REPOLARIZATIONMichael Tamkun; Fiscal Year: 2005..Given the role that both Kv channels and connexins play in cardiac and vascular smooth muscle, the proposed research will significantly advance our understanding of electrical excitability in the cardiovascular system. ..
- Biosynthesis & Function of a Bacillus anthracis-specific cell wall polysaccharideRussell W Carlson; Fiscal Year: 2010..fluoride (HF), and was previously reported to function in anchoring/exporting the S-layer proteins, Sap and EA1, to the cell surface. Our work strongly supports that the HF-PS is structurally specific to B...
- Jason X J Yuan; Fiscal Year: 2016..The long-term goal of this study is to define the mechanism underlying the inhibition of Kv channels in IPAH- PASMC and to explore the possibility to target miRNA for developing therapeutic approaches for IPAH. ..
- MOLECULAR AND CELLULAR PHYSIOLOGY OF EPISODIC ATAXIAJames Maylie; Fiscal Year: 2006Episodic Ataxia / Myokymia Syndrome Type 1 (EA1) is an inherited autosomal dominant human neurological disorder...
- ANGELES RIBERA; Fiscal Year: 2014....
- Mechanisms of Limbic EpileptogenesisJames O McNamara; Fiscal Year: 2010..We seek to determine whether inhibiting TrkB signaling prevents other types of epileptogenesis in animal models. This information will guide efforts aimed at exploiting TrkB as a molecular target for anti-epileptogenic therapies. ..
- MECHANISMS OF REPOLARIZATION-INDUCED ARRHYTHMIASGuy Salama; Fiscal Year: 2002..abstract_text> ..
- Nervous System Channelopathies: Pathogenesis & TreatmentROBERT GRIGGS; Fiscal Year: 2005..there is no established treatment and there have been no well-designed clinical trials; (3) the episodic ataxias EA1 and EA2 for which treatment is not yet defined...
- Gene therapy against conditioned fearRobert Sapolsky; Fiscal Year: 2005....
- AUDITORY SIGNALING, THE FUNCTIONAL ROLE OF KV CHANNELSBRUCE TEMPEL; Fiscal Year: 2003..The proposed studies and models based on the Kvl.1 knockout mouse mutants should also be informative regarding the neuronal dysfunction that underlies this human disease. ..
- PEPTIDOMIMETIC DRUG DESIGN BASED ON SHK TOXINWilliam Kem; Fiscal Year: 1999..3 channel block. Kv1.3 blockers which do not affect other K channels should be useful in treating a variety of immune disorders. ..
- ROLE OF PLEIOTROPHIN IN BREAST CANCERTHOMAS DEUEL; Fiscal Year: 2004..Both MK and MK1-3, 59-121 promote more aggressive tumor growth and perhaps tumor angiogenesis (in progress) when they are ..
- GABAergic Inhibition and the Ketogenic DietJONG RHO; Fiscal Year: 2007..It is expected that the results of these investigations will shed light on the potential role of the KD in epileptogenesis, especially as it relates to effects on GABAergic inhibition ..
- Development of a Novel Retrogen Vaccine for AnthraxAugustine Lin; Fiscal Year: 2004..Various B. anthracis toxin subunits (PA, EF, and LF) and spore surface antigens (EA1, Sap, CapA, CapB, CapC, and Dep) will be tested in conjunction with Retrovax, a proprietary vaccine technology ..
- Ion Channel Disorder MechanismsWILLIAM THORNHILL; Fiscal Year: 2009..This research should also be relevant to other disorders caused by mutations in channel genes. ..
- IONIC CHANNELS IN MAMMALIAN MYELINATED NERVESSHING CHIU; Fiscal Year: 2004..Relatedly, the role of Kvbeta subunits, which colocalize with Kv1.1 and are thought to promote efficient surface expression, will be examined in Kvbeta mutant mice (also generated in our laboratory). ..
- MODULATION OF KV ALPHA POTASSIUM CHANNELSWILLIAM THORNHILL; Fiscal Year: 2000..These experiments form the bases for hypothesizing that channel glycosylation represents an important mechanism of postranslational modulation of ion channel function. ..
- International Conference on Episodic Ataxia SyndromesJoanna Jen; Fiscal Year: 2005..abstract_text> ..
- THE GENETIC & FUNCTIONAL ANATOMICAL BASIS OF HGPPSJoanna Jen; Fiscal Year: 2009..Understanding the anatomical and molecular basis of HGPPS will provide insight into the genetically programmed neurodevelopment of the conjugate horizontal gaze center and other cranial nuclei in the brainstem. ..
- Genetics of Familial Episodic AtaxiaJoanna C Jen; Fiscal Year: 2010Familial episodic ataxia (EA) syndromes are rare and heterogeneous (EA1-EA7 to date) monogenic disorders, the study of which has illuminated previously unrecognized but important roles of ion channels and transporters in neuronal and ..
- MUTATIONS IN CALCIUM CHANNELS CAUSING VERTIGO AND ATAXIAJoanna Jen; Fiscal Year: 2002..The further relevance of this work to the more common basilar migraine and Meniere's syndrome is emphasized by the overlapping symptoms of vertigo and ataxia in the group of patients that we propose to study. ..
- Pathobiology of Retinal Vasculopathy with Cerebal Leukodystrophy (RVCL)Joanna C Jen; Fiscal Year: 2010..abstract_text> ..
- Diseases of the Vestibular SystemRobert Baloh; Fiscal Year: 2006..abstract_text> ..
- DIZZINESS IN OLDER PEOPLERobert Baloh; Fiscal Year: 2006..By continuing this longitudinal study of carefully studied older patients and controls, our multidisciplinary research team is in a good position to achieve our goals. ..
- DEVELOPMENT OF VESTIBULAR NUCLEI NEURONSKENNA PEUSNER; Fiscal Year: 2005..abstract_text> ..
- Neural Analysis of Maternal AggressionSTEPHEN GAMMIE; Fiscal Year: 2006..Basic research into sex differences in aggression, then, is important to understanding the biological underpinnings of sex and gender differences in social behavior, health, and disease. ..
- Genetics of Seizure Resistance: A Mutagenesis StrategySCOTT BARABAN; Fiscal Year: 2004..The results of this unique collaboration promise to provide new insights into the genetic factors that influence epilepsy, and will, perhaps, lead to a cure for this devastating neurological disorder. ..
- MEMBRANE MECHANISMS MEDIATING ALCOHOL INDUCED PATHOLOGYRichard Gross; Fiscal Year: 2001..Collectively, the proposed research represents a multidisciplinary approach designed to dissect the biochemical mechanisms underlying these novel effects of ethanol and ethanol metabolites on hippocampal function. ..
- Axonal alterations in demyelinating diseasesSTEVEN SIMON SCHERER; Fiscal Year: 2011..Aim #3: What Na,K-ATPase isoforms are expressed by myelinated axons and demyelinated axons? we will localize alpha1-3 by immunoelectron microscopy in CMSand PNS myelinated axons, along with their beta subunits. ..
- Molecular mechanisms of dendritic K channel functionLilian Yuan; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- SYNAPTIC TRANSMISSION DURING NEURONAL DIFFERENTIATIONKenna D Peusner; Fiscal Year: 2010..As we learn more about the pathology induced by vestibular deafferentation at the level of vestibular nuclei neurons, effective therapies can be targeted selectively to improve the clinical management of patients with balance disorders. ..
- IONIC CONDUCTANCES AND CD4 LYMPHOCYTE DIFFERENTIATIONBruce Freedman; Fiscal Year: 2001..The central hypothesis of this proposal is that the TCR-mediated calcium response regulates CD4plus lymphocyte differentiation, and that Kv channel regulate the secondary responses of differentiated cells to antigen. ..
- CHRONIC CORONARY OCCLUSION, EXERCISE TRAINING AND NOCristine L Heaps; Fiscal Year: 2010....
- HIV ENV & MACROPHAGE CHEMOKINE RECEPTOR IONIC SIGNALINGBruce Freedman; Fiscal Year: 2004....
- TRINUCLEOTIDE REPEATS AND NEUROLOGIC DISEASERussell Margolis; Fiscal Year: 2004..Overall, the proposed experiments will enable a systematic test for CAG/CTG expansion mutations in a variety of devastating neurodegenerative diseases. ..
- The Role of Connexin32 in the Pathogenesis of CMTXSteven Scherer; Fiscal Year: 2006....
- Advances in Renal Research: Human Diseases of Protein ProcessingDavid Ellison; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Seizure resistance in zebrafishSCOTT BARABAN; Fiscal Year: 2009..The results promise to provide new information about the genetics of seizure resistance and may lead to the design of novel anticonvulsant treatments designed to prevent epilepsy. ..
- Dendritic ion channel trafficking in plasticityLilian Yuan; Fiscal Year: 2008..Moreover, the studies proposed above represent our efforts to define the precise dendritic mechanisms involved in an animal model for human neurological diseases. [unreadable] [unreadable]..
- PHOSPHOLIPASE ACTIVATION AND MEMBRANE DYSFUNCTION IN DIABETIC CARDIOMYOPATHYRichard Gross; Fiscal Year: 2008..More specifically, the proposed studies identify the chemical changes in hearts of diabetic patients that lead to altered heart function and ultimately to heart failure. [unreadable] [unreadable] [unreadable]..
- A Mouse Model of RNA-induced NeurotoxcityRussell Margolis; Fiscal Year: 2008..Finding the points of pathogenic convergence in these diseases may provide novel leads for the development of rational therapeutics. ..
- MGE Progenitor Cell Grafts and EpilepsySCOTT BARABAN; Fiscal Year: 2008..abstract_text> ..