Kv1.1

Summary

Gene Symbol: Kv1.1
Description: potassium voltage-gated channel subfamily A member 1
Alias: AEMK, EA1, HBK1, HUK1, KV1.1, MBK1, MK1, RBK1, potassium voltage-gated channel subfamily A member 1, potassium channel, voltage gated shaker related subfamily A, member 1, potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia), voltage-gated K(+) channel HuKI, voltage-gated potassium channel HBK1, voltage-gated potassium channel subunit Kv1.1
Species: human

Top Publications

  1. pmc Voltage-gated K+ channels in rat small cerebral arteries: molecular identity of the functional channels
    Sulayma Albarwani
    Department of Physiology, College of Medicine, Sultan Qaboos University, Al Khod, Sultanate of Oman
    J Physiol 551:751-63. 2003
  2. pmc Functional coupling of intracellular calcium and inactivation of voltage-gated Kv1.1/Kvbeta1.1 A-type K+ channels
    Flora Jow
    Neuroscience Discovery Research, Wyeth Research, CN 8000, Princeton, NJ 08543, USA
    Proc Natl Acad Sci U S A 101:15535-40. 2004
  3. pmc The human Kv1.1 channel is palmitoylated, modulating voltage sensing: Identification of a palmitoylation consensus sequence
    Rose A Gubitosi-Klug
    Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 102:5964-8. 2005
  4. ncbi Episodic ataxia/myokymia syndrome is associated with point mutations in the human potassium channel gene, KCNA1
    D L Browne
    Department of Biochemistry and Molecular Biology, Oregon Health Sciences University, Portland 97201
    Nat Genet 8:136-40. 1994
  5. ncbi A novel mutation in the human voltage-gated potassium channel gene (Kv1.1) associates with episodic ataxia type 1 and sometimes with partial epilepsy
    S M Zuberi
    Department of Neurology and Child Development, Royal Hospital for Sick Children, Glasgow, UK
    Brain 122:817-25. 1999
  6. ncbi Clinical, genetic, and expression studies of mutations in the potassium channel gene KCNA1 reveal new phenotypic variability
    L H Eunson
    University Department of Clinical Neurology, Institute of Neurology University College of London, Queen Square, UK
    Ann Neurol 48:647-56. 2000
  7. ncbi Nervous system targets of RNA editing identified by comparative genomics
    Barry Hoopengardner
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    Science 301:832-6. 2003
  8. ncbi Expanding the phenotype of potassium channelopathy: severe neuromyotonia and skeletal deformities without prominent Episodic Ataxia
    M Kinali
    Dubowitz Neuromuscular Centre, Hammersmith Hospital, Imperial College School of Medicine, London, UK
    Neuromuscul Disord 14:689-93. 2004
  9. pmc Nongenetic factors influence severity of episodic ataxia type 1 in monozygotic twins
    T D Graves
    MRC Centre for Neuromuscular Diseases, UCL Institute of Neurology, University College London, Queen Square, London, United Kingdom
    Neurology 75:367-72. 2010
  10. pmc Nerve excitability studies characterize Kv1.1 fast potassium channel dysfunction in patients with episodic ataxia type 1
    Susan E Tomlinson
    Institute of Neurology, University College London, London WC1N 3BG, UK
    Brain 133:3530-40. 2010

Research Grants

  1. Role of glycosylation in voltage-gated potassium channels
    Desiree A Thayer; Fiscal Year: 2010
  2. KEITH ALAN VOSSEL; Fiscal Year: 2015
  3. Behavioral Measures of Temporal Resolution in Mice With or Without Kv1.1 Subunits
    Micheal L Dent; Fiscal Year: 2010
  4. DIFFERENTIATION OF NEURONAL SIGNALING MECHANISMS
    MICHAEL BARISH; Fiscal Year: 2000
  5. Excitability mechanisms of neurocardiac regulation
    ALBERT E GLASSCOCK; Fiscal Year: 2012
  6. ALBERT E GLASSCOCK; Fiscal Year: 2015
  7. Functional roles of Kv1 channels in inhibitory cortical interneurons
    Brian D Clark; Fiscal Year: 2010
  8. Targeting of Voltage-gated K+ Channels to Lipid Rafts
    Michael Tamkun; Fiscal Year: 2004
  9. A Mouse Model of Mammalian Shaker Channel RNA Editing
    Tarun Bhalla; Fiscal Year: 2006
  10. REGULATORY MECHANISMS OF CARDIAC REPOLARIZATION
    Michael Tamkun; Fiscal Year: 2005

Detail Information

Publications240 found, 100 shown here

  1. pmc Voltage-gated K+ channels in rat small cerebral arteries: molecular identity of the functional channels
    Sulayma Albarwani
    Department of Physiology, College of Medicine, Sultan Qaboos University, Al Khod, Sultanate of Oman
    J Physiol 551:751-63. 2003
    ..The findings of this study suggest that KV1.2/1.5 heterotetramers are preferentially expressed in rat cerebral VSMCs, and that these channels contribute to the resting membrane potential and diameter of rat small cerebral arteries...
  2. pmc Functional coupling of intracellular calcium and inactivation of voltage-gated Kv1.1/Kvbeta1.1 A-type K+ channels
    Flora Jow
    Neuroscience Discovery Research, Wyeth Research, CN 8000, Princeton, NJ 08543, USA
    Proc Natl Acad Sci U S A 101:15535-40. 2004
    ....
  3. pmc The human Kv1.1 channel is palmitoylated, modulating voltage sensing: Identification of a palmitoylation consensus sequence
    Rose A Gubitosi-Klug
    Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 102:5964-8. 2005
    ....
  4. ncbi Episodic ataxia/myokymia syndrome is associated with point mutations in the human potassium channel gene, KCNA1
    D L Browne
    Department of Biochemistry and Molecular Biology, Oregon Health Sciences University, Portland 97201
    Nat Genet 8:136-40. 1994
    ..Mutation analysis of the KCNA1 coding region in these families identified four different missense point mutations present in the heterozygous state, indicating that EA/myokymia can result from mutations in this gene...
  5. ncbi A novel mutation in the human voltage-gated potassium channel gene (Kv1.1) associates with episodic ataxia type 1 and sometimes with partial epilepsy
    S M Zuberi
    Department of Neurology and Child Development, Royal Hospital for Sick Children, Glasgow, UK
    Brain 122:817-25. 1999
    Episodic ataxia type 1 (EA1) is a rare autosomal dominant disorder characterized by brief episodes of ataxia associated with continuous interattack myokymia. Point mutations in the human voltage-gated potassium channel (Kv1...
  6. ncbi Clinical, genetic, and expression studies of mutations in the potassium channel gene KCNA1 reveal new phenotypic variability
    L H Eunson
    University Department of Clinical Neurology, Institute of Neurology University College of London, Queen Square, UK
    Ann Neurol 48:647-56. 2000
    Episodic ataxia type 1 (EA1) is an autosomal dominant central nervous system potassium channelopathy characterized by brief attacks of cerebellar ataxia and continuous interictal myokymia...
  7. ncbi Nervous system targets of RNA editing identified by comparative genomics
    Barry Hoopengardner
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    Science 301:832-6. 2003
    ..These results point to a pivotal role for RNA editing in nervous system function...
  8. ncbi Expanding the phenotype of potassium channelopathy: severe neuromyotonia and skeletal deformities without prominent Episodic Ataxia
    M Kinali
    Dubowitz Neuromuscular Centre, Hammersmith Hospital, Imperial College School of Medicine, London, UK
    Neuromuscul Disord 14:689-93. 2004
    ..His mother presented some years later with typical features of Episodic Ataxia type 1 (EA1), with episodes of ataxia lasting a few minutes provoked by exercise...
  9. pmc Nongenetic factors influence severity of episodic ataxia type 1 in monozygotic twins
    T D Graves
    MRC Centre for Neuromuscular Diseases, UCL Institute of Neurology, University College London, Queen Square, London, United Kingdom
    Neurology 75:367-72. 2010
    Episodic ataxia type 1 (EA1) is a monogenic channelopathy caused by mutations of the potassium channel gene KCNA1...
  10. pmc Nerve excitability studies characterize Kv1.1 fast potassium channel dysfunction in patients with episodic ataxia type 1
    Susan E Tomlinson
    Institute of Neurology, University College London, London WC1N 3BG, UK
    Brain 133:3530-40. 2010
    ..1 dysfunction in patients with episodic ataxia type 1. The simple 15 min test may be useful in diagnosis, since it can differentiate patients with episodic ataxia type 1 from normal controls with high sensitivity and specificity...
  11. ncbi Episodic ataxia and myokymia syndrome: a new mutation of potassium channel gene Kv1.1
    S Comu
    Department of Pediatrics, University of Pittsburgh, PA, USA
    Ann Neurol 40:684-7. 1996
    ..This disease has been associated with point mutations in the potassium channel gene Kv1.1 (KCNA1), located at chromosome 12p13. Here, we describe a novel mutation within this gene in a newly diagnosed family...
  12. ncbi Three novel KCNA1 mutations in episodic ataxia type I families
    H Scheffer
    Department of Medical Genetics, University of Groningen, The Netherlands
    Hum Genet 102:464-6. 1998
    ..By direct sequence analysis, a different missense mutation of the potassium channel gene (KCNA1) has been identified in three families with EA...
  13. ncbi Characterization of the outer pore region of the apamin-sensitive Ca2+-activated K+ channel rSK2
    Heike Jäger
    Department of Applied Physiology, University of Ulm, Albert Einstein Allee 11, 89081 Ulm, Germany
    Toxicon 43:951-60. 2004
    ..From mutant cycle analysis of KTX position H34 and SK2 position V342G, S344E, and G348D we could deduce that KTX binds in a similar way to SK2 channel mutant pore than to the Kv1.1 pore...
  14. ncbi In vivo selection of Enterobacter aerogenes with reduced susceptibility to cefepime and carbapenems associated with decreased expression of a 40 kDa outer membrane protein and hyperproduction of AmpC beta-lactamase
    Felipe Fernandez-Cuenca
    Department of Microbiology, University of Seville, and University Hospital Virgen Macarena, Seville, Spain
    Int J Antimicrob Agents 27:549-52. 2006
    ..susceptibility to cefepime (FEP) and/or imipenem (IMP) in three consecutive isolates of Enterobacter aerogenes (Ea1, Ea2 and Ea3) cultured from bronchial aspirates of the same patient after treatment with ceftriaxone and FEP were ..
  15. ncbi Ataxias with autosomal, X-chromosomal or maternal inheritance
    Josef Finsterer
    Krankenanstalt Rudolfstiftung, Vienna, Austria, Europe
    Can J Neurol Sci 36:409-28. 2009
    ..spinocerebellar ataxias (SCA1-8, 10-15, 17-23, 25-30, and dentato-rubro-pallido-luysian atrophy), episodic ataxias (EA1-7), and autosomal dominant mitochondrial heredoataxias (Leigh syndrome, MIRAS, ADOAD, and AD-CPEO)...
  16. ncbi The abnormal occurrence and the differentiation-dependent distribution of N-acetyl and N-glycolyl species of the ganglioside GM2 in human germ cell tumors. A study with specific monoclonal antibodies
    M Miyake
    Department of Laboratory Medicine and Clinical Science, School of Medicine, Kyoto University, Japan
    Cancer 65:499-505. 1990
    ..specific monoclonal antibodies which can distinguish the molecular species of the sialic acid moiety: the antibody MK1-16 is specific for N-acetyl GM2, MK2-34 is specific for N-glycolyl GM2, and MK1-17 detects both N-acetyl and N-..
  17. ncbi Identification of mK1, a true tissue (glandular) kallikrein of mouse submandibular gland: tissue distribution and a comparison of kinin-releasing activity with other submandibular kallikreins
    K Hosoi
    Department of Oral Physiology, Meikai University School of Dentistry, Saitama
    J Biochem 115:137-43. 1994
    ..The present results revealed that the former proteinase F is identical to mK1, tissue/renal kallikrein, and confirmed its characteristics as a true kallikrein on the basis of its kinin-..
  18. pmc Differences in substrate and inhibitor sequence specificity of human, mouse and rat tissue kallikreins
    Sandro E Fogaça
    Department of Biophysics, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Rua Tres de Maio 100, São Paulo 04044 20, Brazil
    Biochem J 380:775-81. 2004
    The kininogenase activities of mouse (mK1), rat (rK1) and human (hK1) tissue kallikreins were assayed with the bradykinin-containing synthetic peptides Abz-MTEMARRPPGFSPFRSVTVQNH2 (where Abz stands for o-aminobenzoyl) and Abz-..
  19. pmc Methylamine and benzylamine induced hypophagia in mice: modulation by semicarbazide-sensitive benzylamine oxidase inhibitors and aODN towards Kv1.1 channels
    R Pirisino
    Department of Preclinical and Clinical Pharmacology, Viale Pieraccini, 6, 50134 Florence, Italy
    Br J Pharmacol 134:880-6. 2001
    ..1 blocking activity. Through a reduction of the endogenous breakdown of MET, Bz-SSAO inhibitors enhance the central pharmacological activity of this amine...
  20. ncbi The role of Kv1.2-containing potassium channels in serotonin-induced glutamate release from thalamocortical terminals in rat frontal cortex
    E K Lambe
    Interdepartmental Neuroscience Program and Departments of Psychiatry and Pharmacology, Yale University School of Medicine, New Haven Connecticut 06508, USA
    J Neurosci 21:9955-63. 2001
    ..These results indicate that blockade of Kv1.2-containing potassium channels is part of the mechanism underlying 5-HT-induced glutamate release from thalamocortical terminals...
  21. pmc Presynaptic rat Kv1.2 channels suppress synaptic terminal hyperexcitability following action potential invasion
    Paul D Dodson
    Department of Cell Physiology and Pharmacology, University of Leicester, PO Box 138, Leicester LE1 9HN, UK
    J Physiol 550:27-33. 2003
    ..We conclude that Kv1.2 channels have a general presynaptic function in suppressing terminal hyperexcitability during the depolarising after-potential...
  22. ncbi Engineering-specific pharmacological binding sites for peptidyl inhibitors of potassium channels into KcsA
    Christian Legros
    Institut für Neurale Signalverarbeitung, ZMNH, Universitat Hamburg, Martinistrasse 52, D 20246 Hamburg, Germany
    Biochemistry 41:15369-75. 2002
    ..X chimeras containing the subregion I of the corresponding mammalian Kv1.X channels. This innovative approach may facilitate the high-throughput screening of ligand libraries aimed at the discovery of novel potassium channel modulators...
  23. ncbi Role of disulfide bonds in the structure and potassium channel blocking activity of ShK toxin
    M W Pennington
    Bachem Bioscience Inc, 3700 Horizon Drive, King of Prussia, Pennsylvania 19406, USA
    Biochemistry 38:14549-58. 1999
    ..The possible interactions of this analogue with the channel and the distinction between native secondary and tertiary structure on one hand and global topology imposed by the disulfide bridges on the other are discussed...
  24. ncbi New roles for renal potassium channels
    Carsten A Wagner
    Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    J Nephrol 23:5-8. 2010
    ..Moreover, defects of 2 different potassium channels expressed on opposing membrane domains of the same cells cause distinct symptoms...
  25. pmc A homeobox gene with potential developmental control function in the meristem of the conifer Picea abies
    A Sundås-Larsson
    Department of Physiological Botany, Uppsala University, Villavagen 6, S 752 36, Uppsala, Sweden
    Proc Natl Acad Sci U S A 95:15118-22. 1998
    ..In this report, we describe the first cDNA corresponding to a homeobox gene isolated from a gymnosperm, the HBK1 gene from the conifer Picea abies (L.) Karst (Norway spruce)...
  26. ncbi Involvement of kv1 potassium channels in spreading acidification and depression in the cerebellar cortex
    Gang Chen
    Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA
    J Neurophysiol 94:1287-98. 2005
    ..The dramatic effects of DTX-K suggest a possible connection between SAD and episodic ataxia type 1 (EA1), a Kv1.1 potassium channelopathy. The threshold for evoking SAD was significantly lowered in the Kv1...
  27. ncbi [Expression and properties of potassium channels in human mammary epithelial cell line MCF10A and its possible role in proliferation]
    Jia Liu
    College of Life Science, Liaoning Normal University, Dalian, China
    Sheng Li Xue Bao 62:203-9. 2010
    ....
  28. pmc Contribution of Kv1.2 voltage-gated potassium channel to D2 autoreceptor regulation of axonal dopamine overflow
    Stephanie Fulton
    Department of Pharmacology and Groupe de Recherche sur le Système Nerveux Central, Universite de Montreal, Quebec H3C 3J7, Canada
    J Biol Chem 286:9360-72. 2011
    ..2-containing channels in striatal tissue. These findings underline the contribution of Kv1.2 in the regulation of nigrostriatal DA release by the D2-AR and thereby offer a novel mechanism by which DA release is regulated...
  29. ncbi Differential distribution of Shaker-like and Shab-like K+-channel subunits in goldfish retina and retinal bipolar cells
    S Yazulla
    Department of Neurobiology and Behavior, University at Stony Brook, New York 11794 5230, USA
    J Comp Neurol 396:131-40. 1998
    ....
  30. ncbi Structure-activity relationships of the Kvbeta1 inactivation domain and its putative receptor probed using peptide analogs of voltage-gated potassium channel alpha- and beta-subunits
    S J Lombardi
    Wyeth Ayerst Research, CNS Disorders, Princeton, New Jersey 08543 8000, USA
    J Biol Chem 273:30092-6. 1998
    ..1 alpha subunit is the likely acceptor for the Kvbeta1 inactivation domain and provide information about residues that may underlie the protein-protein interactions responsible for beta-subunit mediated Kv channel inactivation...
  31. pmc Additive and/or synergistic action (downregulation) of androgens and thyroid hormones on the cellular distribution and localization of a true tissue kallikrein, mK1, in the mouse submandibular gland
    Shingo Kurabuchi
    Dept of Histology, Nippon Dental University School of Dentistry at Tokyo, Fujimi 1 9 20, Chiyoda ku, Tokyo 102 8159, Japan
    J Histochem Cytochem 52:1437-46. 2004
    ..5alpha-dihydrotestosterone (DHT), 3,5,3'-triiodo-l-thyronine (T(3)), and dexamethasone (Dex) on the expression of mK1 in the granular convoluted tubule (GCT) cells of the submandibular gland (SMG) of hypophysectomized (Hypox) male ..
  32. pmc Phylogenomic analyses of KCNA gene clusters in vertebrates: why do gene clusters stay intact?
    Simone Hoegg
    Lehrstuhl fur Zoologie und Evolutionsbiologie, Department of Biology, University of Konstanz, 78457 Konstanz, Germany
    BMC Evol Biol 7:139. 2007
    ..Interestingly, this hypothesis does not appear to apply to the KCNA clusters, as too few conserved putative regulatory elements are retained...
  33. ncbi Kv1.1/1.2 channels are downstream effectors of nitric oxide on synaptic GABA release to preautonomic neurons in the paraventricular nucleus
    Q Yang
    Department of Anesthesiology and Pain Medicine, Unit 110, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Neuroscience 149:315-27. 2007
    ..These findings suggest that NO increases GABAergic input to PVN presympathetic neurons through a downstream mechanism involving the Kv1.1 and Kv1.2 channels at the nerve terminals...
  34. doi Recent advances in the genetics of recurrent vertigo and vestibulopathy
    Joanna C Jen
    Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095 1769, USA
    Curr Opin Neurol 21:3-7. 2008
    ..To focus on recent advances in the genetics of recurrent vertigo, with an overview on episodic ataxia, benign recurrent vertigo (mainly migraine-associated vertigo), bilateral vestibulopathy, and Ménière's disease...
  35. ncbi Sensitivity of native and cloned hippocampal delayed-rectifier potassium channels to verapamil
    M Madeja
    Institut fur Physiologie, Munster, Germany
    Neuropharmacology 39:202-10. 2000
    ..1 channel, 98 micromol/l for the Kv1.2 channel, 12 micromol/l for the Kv1.3 channel, 226 micromol/l for the Kv2.1 channel, 6 micromol/l for the Kv3.1 channel and 11 micromol/l for the Kv3.2 channel...
  36. ncbi Truncation of the Shaker-like voltage-gated potassium channel, Kv1.1, causes megencephaly
    Susanna Petersson
    Neurogenetic Unit, Department of Molecular Medicine, CMM, L8 00, Karolinska Institutet, 171 76 Stockholm, Sweden
    Eur J Neurosci 18:3231-40. 2003
    ..However, in contrast to the commonly demonstrated epilepsy-induced neurodegeneration, we find that the mceph mutation leads to seizures with a concomitant increase in brain size, without overt neural atrophy...
  37. ncbi A novel beta subunit increases rate of inactivation of specific voltage-gated potassium channel alpha subunits
    M J Morales
    Department of Pharmacology, Duke University Medical Center, Durham, North Carolina 27710
    J Biol Chem 270:6272-7. 1995
    ..This study shows that voltage-gated K+ channel beta subunits are present outside the central nervous system, and that at least one member of this family selectively modulates inactivation of K+ channel alpha subunits...
  38. pmc Glycosylation affects rat Kv1.1 potassium channel gating by a combined surface potential and cooperative subunit interaction mechanism
    Itaru Watanabe
    Department of Biological Sciences, Fordham University, Bronx, NY 10458, USA
    J Physiol 550:51-66. 2003
    ..Differences in glycosylation pattern among closely related channels may contribute to their functional differences and affect their physiological roles...
  39. ncbi Lack of potassium channel induces proliferation and survival causing increased neurogenesis and two-fold hippocampus enlargement
    Malin Almgren
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Hippocampus 17:292-304. 2007
    ..This phenotype is a result, at least in DG, from increased proliferation, neurogenesis, and enhanced general hippocampal cell survival...
  40. ncbi The investigation of interactions of kappa-Hefutoxin1 with the voltage-gated potassium channels: a computational simulation
    M Zarrabi
    Department of Biophysics, Faculty of Science, Tarbiat Modares University, Tehran, Iran
    Proteins 71:1441-9. 2008
    ....
  41. pmc Arrangement of Kv1 alpha subunits dictates sensitivity to tetraethylammonium
    Ahmed Al-Sabi
    International Centre for Neurotherapeutics, Dublin City University, Dublin 9, Ireland
    J Gen Physiol 136:273-82. 2010
    ..These collective findings indicate that assembly of alpha subunits can be directed by this optimized concatenation, and that subunit arrangement in heteromeric Kv channels affects TEA affinity...
  42. ncbi Differences in androgen-dependent induction of mk1, true tissue kallikrein in C3H/HeN and ICR mouse submandibular gland
    K Kurihara
    Department of Oral Physiology, Meikai University School of Dentistry, Sakado, Saitama, Japan
    Horm Metab Res 31:370-4. 1999
    Androgen-dependent induction of mk1, true tissue kallikrein, in submandibular gland was studied in C3H/HeN and ICR mice and their F1 progeny...
  43. ncbi Amino-terminal determinants of U-type inactivation of voltage-gated K+ channels
    Harley T Kurata
    Department of Physiology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    J Biol Chem 277:29045-53. 2002
    ..1. These data suggest that intersubunit T1 domain interactions influence U-type inactivation in Kv1 channels, and suggest a generalized influence of the T1 domain on U-type inactivation between Kv channel subfamilies...
  44. doi Respiratory syncytial virus, human bocavirus and rhinovirus bronchiolitis in infants
    F Midulla
    Department of Pediatrics, Sapienza University of Rome, Viale Regina Elena 324, 00165 Rome, Italy
    Arch Dis Child 95:35-41. 2010
    ..To investigate the prevalence of 14 viruses in infants with bronchiolitis and to study demographic and clinical differences in those with respiratory syncytial virus (RSV), human bocavirus (hBoV) and rhinovirus (RV) infection...
  45. ncbi The distribution of ganglioside-like moieties in peripheral nerves
    K A Sheikh
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Brain 122:449-60. 1999
    ..1 and Kv1.5 and are thus not likely carried by these ion channels. In contrast with Gal(beta1-3)GalNAc, GT1b-like moieties are restricted to the axolemma...
  46. ncbi Estrogen-dependent expression of the tissue kallikrein gene (Klk1) in the mouse uterus and its implications for endometrial tissue growth
    Sanath Rajapakse
    Division of Biological Sciences, Graduate School of Science, Hokkaido University, Sapporo, Japan
    Mol Reprod Dev 74:1053-63. 2007
    Tissue kallikrein mK1 is a serine protease involved in the generation of bioactive kinins for normal cardiac and arterial function in the mouse...
  47. doi Identification of amino acids in the pore region of Kv1.2 potassium channel that regulate its glycosylation and cell surface expression
    Iku Utsunomiya
    Department of Pharmacotherapeutics, Showa Pharmaceutical University, Tokyo, Japan
    J Neurochem 112:913-23. 2010
    ..2 is regulated by specific amino acids in the pore region in a similar manner to Kv1.1 and Kv1.4, and that the cell surface expression of Kv1.2, a channel intermediate between Kv1.1 and Kv1.4, can be attributed to these specific residues...
  48. ncbi A family of three mouse potassium channel genes with intronless coding regions
    K G Chandy
    Department of Medicine, University of California, Irvine 92717
    Science 247:973-5. 1990
    ..channels in mammalian cells, mouse genomic clones have been isolated with a potassium channel complementary DNA, MBK1, that is homologous to the Drosophila potassium channel gene, Shaker...
  49. ncbi Deranged Kv channel regulation in fibroblasts from mice lacking the serum and glucocorticoid inducible kinase SGK1
    Ekaterina Shumilina
    Department of Physiology, University of Tuebingen, Germany
    J Cell Physiol 204:87-98. 2005
    ..In conclusion, lack of SGK1 does not abrogate Kv channel activity but abolishes regulation of those channels by serum, glucocorticoids and IGF-1, an effect influencing capacitative Ca(2+) entry...
  50. ncbi Fast apoptosis and erythroid differentiation induced by imatinib mesylate in JURL-MK1 cells
    Katerina Kuzelova
    Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20 Prague 2, Czech Republic
    J Cell Biochem 95:268-80. 2005
    We compare the effects of Imatinib mesylate (Glivec) on chronic myeloid leukemia derived cell lines K562 and JURL-MK1. In both cell lines, the cell cycle arrests in G(1)/G(0) phase within 24 h after the addition of 1 microM Imatinib...
  51. ncbi Neuromyotonia and limbic encephalitis sera target mature Shaker-type K+ channels: subunit specificity correlates with clinical manifestations
    Kleopas A Kleopa
    Department of Clinical Neurosciences, Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus, PA, USA
    Brain 129:1570-84. 2006
    ..Although more than one type of antibody is often detectable in individual sera, higher affinity for certain subunits or subunit combinations may determine the range of clinical manifestations...
  52. doi Real time detection of anthrax spores using highly specific anti-EA1 recombinant antibodies produced by competitive panning
    Tracey E Love
    Detection Department, Dstl Porton Down, Salisbury, Wiltshire, SP4 OJQ, United Kingdom
    J Immunol Methods 334:1-10. 2008
    ..The aim was to produce single chain antibodies (scFvs) to EA1, a Bacillus anthracis S-layer protein that is also present, although not identical, in related to Bacillus species...
  53. ncbi Kv1.1 and Kv1.3 channels contribute to the delayed-rectifying K+ conductance in rat choroid plexus epithelial cells
    Tracey Speake
    School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    Am J Physiol Cell Physiol 286:C611-20. 2004
    ..In conclusion, Kv1.1 and Kv1.3 channels make a significant contribution to K+ efflux at the apical membrane of the choroid plexus...
  54. doi Kv1.1 and Kv1.3 channels contribute to the degeneration of retinal ganglion cells after optic nerve transection in vivo
    P D Koeberle
    Division of Anatomy, Department of Surgery, University of Toronto, Ontario, Canada
    Cell Death Differ 17:134-44. 2010
    ..Kv1.1 depletion increased the antiapoptotic gene, Bcl-X(L), whereas Kv1.3 depletion reduced the proapoptotic genes, caspase-3, caspase-9 and Bad...
  55. ncbi Both N- and C-terminal regions contribute to the assembly and functional expression of homo- and heteromultimeric voltage-gated K+ channels
    W F Hopkins
    Geriatric Research Education and Clinical Center, Veterans Affairs Medical Center, Seattle, Washington 98108
    J Neurosci 14:1385-93. 1994
    ..1 (MBK1), a mouse Shaker-like K+ channel...
  56. ncbi Immunological identification of the Shaker-related Kv1.3 potassium channel protein in T and B lymphocytes, and detection of related proteins in files and yeast
    R H Spencer
    Department of Microbiology and Molecular Genetics, University of California, Irvine 92717
    Biochem Biophys Res Commun 191:201-6. 1993
    ..Abs which recognize these shared epitopes could serve for the identification and biochemical characterization of Shaker-related proteins in diverse organisms...
  57. ncbi Peptidyl inhibitors of shaker-type Kv1 channels elicit twitches in guinea pig ileum by blocking kv1.1 at enteric nervous system and enhancing acetylcholine release
    G Suarez-Kurtz
    Coordenação de Pesquisa, Instituto Nacional de Cancer, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    J Pharmacol Exp Ther 289:1517-22. 1999
    ..1. The data taken together suggest that high-affinity blockade of Kv1.1 underlies the ability of MgTX, kaliotoxin, agitoxin-1, agitoxin-2, alpha-dendrotoxin, and stichodactylatoxin to elicit TTX-sensitive twitches in guinea pig ileum...
  58. ncbi Maurotoxin and the Kv1.1 channel: voltage-dependent binding upon enantiomerization of the scorpion toxin disulfide bridge Cys31-Cys34
    C Lecomte
    Laboratoire de Biochimie, CNRS UMR 6560, IFR Jean Roche, Faculte de Medecine Nord, Marseille, France
    J Pept Res 55:246-54. 2000
    ..3, and to a lesser extent, Kv1.2 channels and it may contribute to the stabilization and strength of the interaction between the toxin and the Kv1.1 channel...
  59. ncbi Subunit composition and novel localization of K+ channels in spinal cord
    M N Rasband
    Department of Biochemistry and Cell Biology and Institute for Cell and Developmental Biology, State University of New York, Stony Brook, NY 11794, USA
    J Comp Neurol 429:166-76. 2001
    ..Moreover, the conservation of these characteristics between human, rat, and bovine nodes of Ranvier suggests an essential role for this defined channel complex in spinal cord function...
  60. ncbi Comparison of exhaust emissions from Swedish environmental classified diesel fuel (MK1) and European Program on Emissions, Fuels and Engine Technologies (EPEFE) reference fuel: a chemical and biological characterization, with viewpoints on cancer risk
    R Westerholm
    Department of Analytical Chemistry, Arrhenius Laboratory, Stockholm University, S 106 91 Stockholm, Sweden
    Environ Sci Technol 35:1748-54. 2001
    ..of the present investigation was to compare the most stringent, environmentally classified Swedish diesel fuel (MK1) to the reference diesel fuel used in the "European Program on Emissions, Fuels and Engine Technologies" (EPEFE) ..
  61. ncbi Interleukin-4 downregulates nuclear factor-erythroid 2 (NF-E2) expression in primary megakaryocytes and in megakaryoblastic cell lines
    L Catani
    Istituto di Ematologia e Oncologia Medica L e A Seragnoli, University of Bologna Italy
    Stem Cells 19:339-47. 2001
    ..factor-beta1 (TGF-beta1) on the expression of NF-E2 transcription factor in megakaryoblastic cell lines (Hel and MK1) and in normal CD34-derived megakaryocytic cells...
  62. ncbi Differential Ca(2+)responses induced by thrombin and thrombin-receptor agonist peptides in HSY-EA1 cells
    Akihiko Tanimura
    Department of Dental Pharmacology, School of Dentistry, Health Sciences University of Hokkaido, Ishikari Tobetsu, Hokkaido 061 0293, Japan
    Cell Biol Int 27:1017-23. 2003
    ..desensitized by comparing the effect of thrombin and the soluble agonist peptide SFLLRN on Ca(2+)responses in HSY-EA1 cells...
  63. ncbi Molecular docking of the scorpion toxin Tc1 to the structural model of the voltage-gated potassium channel Kv1.1 from human Homo sapiens
    Hsuan Liang Liu
    Department of Chemical Engineering, Graduate Institute of Biotechnology, National Taipei University of Technology, No 1 Sec 3 Chung Hsiao E Rd, Taipei, Taiwan 10608
    J Biomol Struct Dyn 21:639-50. 2004
    ..1. Furthermore, surface complementarity of the outer vestibules of the channels to the Tc1 spatial conformations also plays an important role in stabilizing both the Tc1/KcsA and Tc1/Kv1.1 complexes...
  64. ncbi Age-related changes in the distribution of Kv1.1 and Kv3.1 in rat cochlear nuclei
    Do Kwang Jung
    Department of Otolaryngology Head and Neck Surgery, College of Medicine, Chung Ang University, 221 Heukseok dong, Dongjak Gu, Seoul 156 756, Korea
    Neurol Res 27:436-40. 2005
    ..1 and Kv3.1 in the auditory brainstem of adult and aged rats...
  65. ncbi The D-diastereomer of ShK toxin selectively blocks voltage-gated K+ channels and inhibits T lymphocyte proliferation
    Christine Beeton
    Department of Physiology and Biophysics, University of California, California, Irvine, 92697 4560, USA
    J Biol Chem 283:988-97. 2008
    ..Being resistant to proteolysis and nonantigenic, this analogue should be useful in K(+) channel studies; all-d analogues with improved Kv1.3 potency and specificity may have therapeutic advantages...
  66. doi Determination of editors at the novel A-to-I editing positions
    Yoshinori Nishimoto
    Department of Neurology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Neurosci Res 61:201-6. 2008
    ..Because ADAR2 underactivity may be a causative molecular change of death of motor neurons in sporadic amyotrophic lateral sclerosis (ALS), this newly identified ADAR2-mediated editing position may become a useful tool for ALS research...
  67. pmc Regulation of intrinsic excitability in hippocampal neurons by activity-dependent modulation of the KV2.1 potassium channel
    Durga P Mohapatra
    Department of Neurobiology, Physiology and Behavior, College of Biological Sciences, University of California, Davis, CA 95616 8519, USA
    Channels (Austin) 3:46-56. 2009
    ..1-containing channels. These studies together demonstrate a specific contribution of modulation of KV2.1 channels in the activity-dependent regulation of intrinsic neuronal excitability...
  68. doi Down-regulation of delayed rectifier K+ channels in the hippocampus of seizure sensitive gerbils
    Sang Moo Lee
    Department of Neurology, College of Medicine, Hallym University, Chunchon 200 702, Kangwon Do, South Korea
    Brain Res Bull 80:433-42. 2009
    ..1, Kv1.2, Kv1.5, Kv1.6, Kv2.1 and Kv3.1-2), not A-type K(+) channels (Kv1.4, Kv3.4 and Kv4.x), may be down-regulated in the SS gerbil hippocampus, as compared to SR gerbils...
  69. doi Clinical neurophysiology of the episodic ataxias: insights into ion channel dysfunction in vivo
    Susan E Tomlinson
    Institute of Clinical Neurosciences, Royal Prince Alfred Hospital and University of Sydney, Sydney, Australia
    Clin Neurophysiol 120:1768-76. 2009
    ..The clinical, genetic and electrophysiological features of EA1 and EA2 are outlined, and a protocol for the assessment of these patients is proposed.
  70. doi Increase of Kv3.1b expression in avian auditory brainstem neurons correlates with synaptogenesis in vivo and in vitro
    Thomas Kuenzel
    Institute of Biology 2, RWTH Aachen University, Aachen, Germany
    Brain Res 1302:64-75. 2009
    ....
  71. doi Molecular remodeling of potassium channels in fibroblasts from centenarians: a marker of longevity?
    Isabella Zironi
    Department of Physics, University of Bologna, 40127 Bologna, Italy
    Mech Ageing Dev 131:674-81. 2010
    ..The maintenance of "young" K(+) currents and the peculiar age-related remodeling of K(+) channel subtypes in centenarian's DF is likely associated with successful aging and might provide a predictive marker of longevity...
  72. pmc Protein 4.1B contributes to the organization of peripheral myelinated axons
    Carmen Cifuentes-Diaz
    INSERM, UMR S 839, Paris, France
    PLoS ONE 6:e25043. 2011
    ..Thus, our results show that in myelinated axons 4.1B contributes to the stabilization of membrane proteins at paranodes, to the clustering of juxtaparanodal proteins, and to the regulation of the internodal axon caliber...
  73. doi A-to-I RNA editing modulates the pharmacology of neuronal ion channels and receptors
    A K Streit
    Institute for Physiology and Pathophysiology, Vegetative Physiology, Philipps University Marburg, Marburg, 35037, Germany
    Biochemistry (Mosc) 76:890-9. 2011
    ..1 channel, and the 5-HT(2C) receptor. Our review summarizes that RNA editing of these proteins does not only change protein function, but also the pharmacology and presumably the drug therapy in human diseases...
  74. doi Mechanism of accelerated current decay caused by an episodic ataxia type-1-associated mutant in a potassium channel pore
    Christian J Peters
    Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
    J Neurosci 31:17449-59. 2011
    ....
  75. doi Affinity and selectivity of ShK toxin for the Kv1 potassium channels from free energy simulations
    M Harunur Rashid
    School of Physics, University of Sydney, New South Wales 2006, Australia
    J Phys Chem B 116:4812-22. 2012
    ..The insights gained on Kv1.x-ShK binding modes will be valuable in the development of new ShK analogues with better selectivity properties. ..
  76. pmc Secretion genes as determinants of Bacillus anthracis chain length
    Sao Mai Nguyen-Mau
    Howard Taylor Ricketts Laboratory, Argonne National Laboratory, Argonne, Illinois, USA
    J Bacteriol 194:3841-50. 2012
    ..Both secA2 and slaP are required for the efficient secretion of Sap and EA1 (Eag), the two S-layer proteins of B...
  77. doi Expression of the voltage-gated potassium channel subunit Kv1.1 in embryonic zebrafish Mauthner cells
    Daniel L Brewster
    Department of Biological Sciences, Biological Sciences Building, University of Alberta, Edmonton, Alberta, Canada T6G 2E9
    Neurosci Lett 539:54-9. 2013
    ..Together, these results suggest that Mauthner cells express potassium channels that contain Kv1.1 subunits, which might contribute to cell firing...
  78. doi Spatio-temporal patterns of genetic change amongst populations of cassava Bemisia tabaci whiteflies driving virus pandemics in East and Central Africa
    James P Legg
    International Institute of Tropical Agriculture IITA, PO Box 34441, Dar es Salaam, Tanzania Electronic address
    Virus Res 186:61-75. 2014
    ..Eight phylogenetically distinct groups were identified, including one, designated herein as 'East Africa 1' (EA1), not previously described. The three most frequently occurring groups comprised >95% of all samples...
  79. ncbi [The reasons why 13 MK1 attachment were re-fabricated and some methods for improvement]
    Zhi hong Wu
    Department of Prosthodontics, Affiliated Stomatological Hospital of Jiujiang University Jiujiang 332000, Jiangxi
    Shanghai Kou Qiang Yi Xue 22:715-7. 2013
    To investigate the reasons why 13 MK1 attachment were re-fabricated and to suggest some improvement methods.
  80. pmc Using constellation pharmacology to define comprehensively a somatosensory neuronal subclass
    Russell W Teichert
    Department of Biology, University of Utah, Salt Lake City, UT 84112
    Proc Natl Acad Sci U S A 111:2319-24. 2014
    ..The broad implications of this study are that it is now feasible to track changes in receptor and ion-channel expression in individual neuronal subclasses as a function of development, learning, disease, or aging. ..
  81. pmc Selective Loss of Presynaptic Potassium Channel Clusters at the Cerebellar Basket Cell Terminal Pinceau in Adam11 Mutants Reveals Their Role in Ephaptic Control of Purkinje Cell Firing
    Matthew J Kole
    Developmental Neurogenetics Laboratory, Department of Neurology
    J Neurosci 35:11433-44. 2015
    ..Our findings identify a critical role for presynaptic K(+) channels at the pinceau in ephaptic control over the speed and stability of spike rate coding at the Purkinje cell AIS in mice...
  82. pmc Scorpion Potassium Channel-blocking Defensin Highlights a Functional Link with Neurotoxin
    Lanxia Meng
    From the State Key Laboratory of Virology, College of Life Sciences and
    J Biol Chem 291:7097-106. 2016
    ..These findings not only demonstrate that defensins from invertebrate animals are a novel type of potassium channel blockers but also provide evidence of a functional link between defensins and neurotoxins...
  83. pmc Pore size matters for potassium channel conductance
    David Naranjo
    Centro Interdisciplinario de Neurociencia de Valparaíso, Universidad de Valparaiso, Playa Ancha, Valparaíso 2360103, Chile
    J Gen Physiol 148:277-91. 2016
    ..Here we raise the idea that the physical dimensions of the hydrophobic internal vestibule limit ion transport in K(+) channels, accounting for their diversity in unitary conductance. ..
  84. ncbi Genomic organization, nucleotide sequence, biophysical properties, and localization of the voltage-gated K+ channel gene KCNA4/Kv1.4 to mouse chromosome 2/human 11p14 and mapping of KCNC1/Kv3.1 to mouse 7/human 11p14.3-p15.2 and KCNA1/Kv1.1 to human 12p13
    R S Wymore
    Department of Physiology, University of California, Irvine 92717
    Genomics 20:191-202. 1994
    ..1, lies approximately 1.8 cM from the Myod-1 gene on mouse chromosome 7, and in situ hybridization localizes KCNC1/hKv3.1 to the homologous region on human chromosome 11p14.3-p15.2. A third gene, KCNA1/hKv1.1, was mapped to human 12p13...
  85. ncbi Nodes, paranodes, and incisures: from form to function
    S S Scherer
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    Ann N Y Acad Sci 883:131-42. 1999
    ..Reflexive gap junctions, comprising connexin32 and at least one other connexin protein, form a radial pathway for the diffusion of ions and small molecules directly across the myelin sheath...
  86. ncbi KChAP as a chaperone for specific K(+) channels
    Y A Kuryshev
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44109 1998, USA
    Am J Physiol Cell Physiol 278:C931-41. 2000
    ..1 and Kv4.3 from heart. We propose that KChAP is a chaperone for specific Kv channels and may have this function in cardiomyocytes where Kv4.3 produces the transient outward current, I(to)...
  87. ncbi Heteromeric Kv1 potassium channel expression: amino acid determinants involved in processing and trafficking to the cell surface
    Jing Zhu
    Department of Biological Sciences, Fordham University, Bronx, New York 10458, USA
    J Biol Chem 278:25558-67. 2003
    ..Thus a neuron may regulate its cell surface K+ channel protein levels by different Kv1 subfamily homomeric and heteromeric combinations that affect intracellular retention characteristics and protein stability...
  88. ncbi Structural and functional alterations of spinal cord axons in adult Long Evans Shaker (LES) dysmyelinated rats
    Eftekhar Eftekharpour
    Division of Cell and Molecular Biology, Toronto Western Research Institute, Krembil Neuroscience Center, McMaster University, Hamilton, Canada
    Exp Neurol 193:334-49. 2005
    ..Further understanding of these issues in this model could provide critical insights for neurological disorders characterized by demyelination...
  89. ncbi Episodic ataxia type 1 mutations in the KCNA1 gene impair the fast inactivation properties of the human potassium channels Kv1.4-1.1/Kvbeta1.1 and Kv1.4-1.1/Kvbeta1.2
    Paola Imbrici
    University of Perugia School of Medicine, Department of Internal Medicine, Section of Human Physiology, Via del Giochetto, I 06126 Perugia, Italy
    Eur J Neurosci 24:3073-83. 2006
    Episodic ataxia type 1 (EA1) is an autosomal dominant neurological disorder characterized by constant muscle rippling movements (myokymia) and episodic attacks of ataxia...
  90. pmc The voltage-gated K+ channel subunit Kv1.1 links kidney and brain
    David H Ellison
    Division of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Clin Invest 119:763-6. 2009
    ..Mechanisms by which the apical voltage is generated and howKv1.1 fits within this context are discussed herein...
  91. doi Mutually exclusive distribution of the sap and eag S-layer genes and the lytB/lytA cell wall hydrolase genes in Bacillus thuringiensis
    Brahim Soufiane
    Agriculture and Agri Food Canada, Research and Development Centre, 430 Gouin Blvd, Saint Jean sur Richelieu, QC, Canada
    Antonie Van Leeuwenhoek 100:349-64. 2011
    ..not of the expected crystal (Cry) proteins but rather of the surface layer proteins (SLP) Sap (encoded by sap) and EA1 (encoded by eag), respectively. Whether the presence of the sap and eag genes is restricted to these two B...
  92. pmc Clinical, genetic, neurophysiological and functional study of new mutations in episodic ataxia type 1
    Susan Elizabeth Tomlinson
    MRC Centre for Neuromuscular Disease, National Hospital for Neurology and Neurosurgery, London, UK
    J Neurol Neurosurg Psychiatry 84:1107-12. 2013
    Heterozygous mutations in KCNA1 cause episodic ataxia type 1 (EA1), an ion channel disorder characterised by brief paroxysms of cerebellar dysfunction and persistent neuromyotonia...
  93. pmc Real-time analysis of imatinib- and dasatinib-induced effects on chronic myelogenous leukemia cell interaction with fibronectin
    Adam Obr
    Department of Cellular Biochemistry, Institute of Hematology and Blood Transfusion, Prague, Czech Republic Department of Cell Biology, Faculty of Science, Charles University in Prague, Prague, Czech Republic
    PLoS ONE 9:e107367. 2014
    ..real-time monitoring of microimpedance, we studied in detail the kinetics of interaction of human CML cells (JURL-MK1, MOLM-7) and of control BCR-ABL-negative leukemia cells (HEL, JURKAT) with fibronectin-coated surface...
  94. pmc Advances on genetic rat models of epilepsy
    Tadao Serikawa
    Graduate School of Medicine, Kyoto University, Sakyo ku 606 8501 Laboratory of Pharmacology, Osaka University of Pharmaceutical Sciences, Takatsuki 569 1094, Japan
    Exp Anim 64:1-7. 2015
    ..In addition, we have established episodic ataxia type 1 (EA1) model rats with a Kcna1 missense mutation derived from the ENU-induced rat mutant stock, and identified a Cacna1a ..
  95. doi Production and cell surface display of recombinant anthrax protective antigen on the surface layer of attenuated Bacillus anthracis
    Yan Chun Wang
    State Key Laboratory of Pathogens and Biosecurity, Beijing Institute of Biotechnology, 20 Dongdajie Street, Fengtai District, Beijing, 100071, China
    World J Microbiol Biotechnol 31:345-52. 2015
    ..a translational fusion harboring the DNA fragments encoding the cell wall-targeting domain of the S-layer protein EA1 and the anthrax PA. Crerecombinase action at the loxP sites excised the antibiotic marker...
  96. doi Assembly of juxtaparanodes in myelinating DRG culture: Differential clustering of the Kv1/Caspr2 complex and scaffolding protein 4.1B
    Bruno Hivert
    Aix Marseille Universite, CNRS, Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille UMR7286, Marseille, France
    Glia 64:840-52. 2016
    ..Thus, developing an adapted culture paradigm, we provide new insights into the dynamic and differential distribution of Kv1 channels and associated proteins during myelination...
  97. pmc Expression and chromosomal localization of a lymphocyte K+ channel gene
    S Grissmer
    Department of Physiology and Biophysics, University of California, Irvine 92715
    Proc Natl Acad Sci U S A 87:9411-5. 1990
    We recently isolated a family of three closely related mouse K+ channel genes (MK1, MK2, and MK3) with coding regions contained in single uninterrupted exons...
  98. ncbi The brain Kv1.1 potassium channel: in vitro and in vivo studies on subunit assembly and posttranslational processing
    K K Deal
    Department of Pharmacology, Vanderbilt Medical School, Nashville, Tennessee 37232
    J Neurosci 14:1666-76. 1994
    ..Together these results suggest (1) heteromeric assembly of Shaker-like channels is cotranslational, and (2) N207 glycosylation of Kv1.1 occurs but is not required for subunit assembly, transport, or function...
  99. pmc Molecular cloning of a glibenclamide-sensitive, voltage-gated potassium channel expressed in rabbit kidney
    X Yao
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Clin Invest 97:2525-33. 1996
    ..We conclude that rabKv1.3 is a novel member of the Shaker superfamily that may play an important role in renal potassium transport...
  100. ncbi A gene for autosomal dominant paroxysmal choreoathetosis/spasticity (CSE) maps to the vicinity of a potassium channel gene cluster on chromosome 1p, probably within 2 cM between D1S443 and D1S197
    G Auburger
    Department of Neurology, University Hospital, Dusseldorf, Germany
    Genomics 31:90-4. 1996
    ..2 at a recombination fraction theta = 0 to D1S451/421/447/GGAT4C11. Crossing-over events in 9 patients and 4 unaffected offspring suggested a probable assignment of the gene to a region of 2 cM between D1S443 and D1S197...
  101. ncbi Association and colocalization of the Kvbeta1 and Kvbeta2 beta-subunits with Kv1 alpha-subunits in mammalian brain K+ channel complexes
    K J Rhodes
    Central Nervous System Disorders, Wyeth Ayerst Research, Princeton, New Jersey 08543, USA
    J Neurosci 17:8246-58. 1997
    ....

Research Grants52

  1. Role of glycosylation in voltage-gated potassium channels
    Desiree A Thayer; Fiscal Year: 2010
    ....
  2. KEITH ALAN VOSSEL; Fiscal Year: 2015
    ..The mentoring and research experience described in this proposal will facilitate the candidate's goal of developing a strong independent research career. ..
  3. Behavioral Measures of Temporal Resolution in Mice With or Without Kv1.1 Subunits
    Micheal L Dent; Fiscal Year: 2010
    ..It is unknown, however, how this affects the 'real world'listening situation of these animals, so this will be determined here. ..
  4. DIFFERENTIATION OF NEURONAL SIGNALING MECHANISMS
    MICHAEL BARISH; Fiscal Year: 2000
    ....
  5. Excitability mechanisms of neurocardiac regulation
    ALBERT E GLASSCOCK; Fiscal Year: 2012
    ....
  6. ALBERT E GLASSCOCK; Fiscal Year: 2015
    ..abstract_text> ..
  7. Functional roles of Kv1 channels in inhibitory cortical interneurons
    Brian D Clark; Fiscal Year: 2010
    ..This research focuses on the role of these proteins in inhibitory cells in the cortex and is a contribution to understanding the pathophysiology of epilepsy in humans. ..
  8. Targeting of Voltage-gated K+ Channels to Lipid Rafts
    Michael Tamkun; Fiscal Year: 2004
    ..1-containing lipid rafts from brain. This proposed research examines a new area in Kv channel research that will have important implications in multiple tissue systems. ..
  9. A Mouse Model of Mammalian Shaker Channel RNA Editing
    Tarun Bhalla; Fiscal Year: 2006
    ..Episodic Ataxia / Myokymia Syndrome Type 1 (EA1) is the only human ataxia known to be caused by dysfunction of a K+ channel...
  10. REGULATORY MECHANISMS OF CARDIAC REPOLARIZATION
    Michael Tamkun; Fiscal Year: 2005
    ..Given the role that both Kv channels and connexins play in cardiac and vascular smooth muscle, the proposed research will significantly advance our understanding of electrical excitability in the cardiovascular system. ..
  11. Biosynthesis & Function of a Bacillus anthracis-specific cell wall polysaccharide
    Russell W Carlson; Fiscal Year: 2010
    ..fluoride (HF), and was previously reported to function in anchoring/exporting the S-layer proteins, Sap and EA1, to the cell surface. Our work strongly supports that the HF-PS is structurally specific to B...
  12. Jason X J Yuan; Fiscal Year: 2016
    ..The long-term goal of this study is to define the mechanism underlying the inhibition of Kv channels in IPAH- PASMC and to explore the possibility to target miRNA for developing therapeutic approaches for IPAH. ..
  13. MOLECULAR AND CELLULAR PHYSIOLOGY OF EPISODIC ATAXIA
    James Maylie; Fiscal Year: 2006
    Episodic Ataxia / Myokymia Syndrome Type 1 (EA1) is an inherited autosomal dominant human neurological disorder...
  14. ANGELES RIBERA; Fiscal Year: 2014
    ....
  15. Mechanisms of Limbic Epileptogenesis
    James O McNamara; Fiscal Year: 2010
    ..We seek to determine whether inhibiting TrkB signaling prevents other types of epileptogenesis in animal models. This information will guide efforts aimed at exploiting TrkB as a molecular target for anti-epileptogenic therapies. ..
  16. MECHANISMS OF REPOLARIZATION-INDUCED ARRHYTHMIAS
    Guy Salama; Fiscal Year: 2002
    ..abstract_text> ..
  17. Nervous System Channelopathies: Pathogenesis & Treatment
    ROBERT GRIGGS; Fiscal Year: 2005
    ..there is no established treatment and there have been no well-designed clinical trials; (3) the episodic ataxias EA1 and EA2 for which treatment is not yet defined...
  18. Gene therapy against conditioned fear
    Robert Sapolsky; Fiscal Year: 2005
    ....
  19. AUDITORY SIGNALING, THE FUNCTIONAL ROLE OF KV CHANNELS
    BRUCE TEMPEL; Fiscal Year: 2003
    ..The proposed studies and models based on the Kvl.1 knockout mouse mutants should also be informative regarding the neuronal dysfunction that underlies this human disease. ..
  20. PEPTIDOMIMETIC DRUG DESIGN BASED ON SHK TOXIN
    William Kem; Fiscal Year: 1999
    ..3 channel block. Kv1.3 blockers which do not affect other K channels should be useful in treating a variety of immune disorders. ..
  21. ROLE OF PLEIOTROPHIN IN BREAST CANCER
    THOMAS DEUEL; Fiscal Year: 2004
    ..Both MK and MK1-3, 59-121 promote more aggressive tumor growth and perhaps tumor angiogenesis (in progress) when they are ..
  22. GABAergic Inhibition and the Ketogenic Diet
    JONG RHO; Fiscal Year: 2007
    ..It is expected that the results of these investigations will shed light on the potential role of the KD in epileptogenesis, especially as it relates to effects on GABAergic inhibition ..
  23. Development of a Novel Retrogen Vaccine for Anthrax
    Augustine Lin; Fiscal Year: 2004
    ..Various B. anthracis toxin subunits (PA, EF, and LF) and spore surface antigens (EA1, Sap, CapA, CapB, CapC, and Dep) will be tested in conjunction with Retrovax, a proprietary vaccine technology ..
  24. Ion Channel Disorder Mechanisms
    WILLIAM THORNHILL; Fiscal Year: 2009
    ..This research should also be relevant to other disorders caused by mutations in channel genes. ..
  25. IONIC CHANNELS IN MAMMALIAN MYELINATED NERVES
    SHING CHIU; Fiscal Year: 2004
    ..Relatedly, the role of Kvbeta subunits, which colocalize with Kv1.1 and are thought to promote efficient surface expression, will be examined in Kvbeta mutant mice (also generated in our laboratory). ..
  26. MODULATION OF KV ALPHA POTASSIUM CHANNELS
    WILLIAM THORNHILL; Fiscal Year: 2000
    ..These experiments form the bases for hypothesizing that channel glycosylation represents an important mechanism of postranslational modulation of ion channel function. ..
  27. International Conference on Episodic Ataxia Syndromes
    Joanna Jen; Fiscal Year: 2005
    ..abstract_text> ..
  28. THE GENETIC & FUNCTIONAL ANATOMICAL BASIS OF HGPPS
    Joanna Jen; Fiscal Year: 2009
    ..Understanding the anatomical and molecular basis of HGPPS will provide insight into the genetically programmed neurodevelopment of the conjugate horizontal gaze center and other cranial nuclei in the brainstem. ..
  29. Genetics of Familial Episodic Ataxia
    Joanna C Jen; Fiscal Year: 2010
    Familial episodic ataxia (EA) syndromes are rare and heterogeneous (EA1-EA7 to date) monogenic disorders, the study of which has illuminated previously unrecognized but important roles of ion channels and transporters in neuronal and ..
  30. MUTATIONS IN CALCIUM CHANNELS CAUSING VERTIGO AND ATAXIA
    Joanna Jen; Fiscal Year: 2002
    ..The further relevance of this work to the more common basilar migraine and Meniere's syndrome is emphasized by the overlapping symptoms of vertigo and ataxia in the group of patients that we propose to study. ..
  31. Pathobiology of Retinal Vasculopathy with Cerebal Leukodystrophy (RVCL)
    Joanna C Jen; Fiscal Year: 2010
    ..abstract_text> ..
  32. Diseases of the Vestibular System
    Robert Baloh; Fiscal Year: 2006
    ..abstract_text> ..
  33. DIZZINESS IN OLDER PEOPLE
    Robert Baloh; Fiscal Year: 2006
    ..By continuing this longitudinal study of carefully studied older patients and controls, our multidisciplinary research team is in a good position to achieve our goals. ..
  34. DEVELOPMENT OF VESTIBULAR NUCLEI NEURONS
    KENNA PEUSNER; Fiscal Year: 2005
    ..abstract_text> ..
  35. Neural Analysis of Maternal Aggression
    STEPHEN GAMMIE; Fiscal Year: 2006
    ..Basic research into sex differences in aggression, then, is important to understanding the biological underpinnings of sex and gender differences in social behavior, health, and disease. ..
  36. Genetics of Seizure Resistance: A Mutagenesis Strategy
    SCOTT BARABAN; Fiscal Year: 2004
    ..The results of this unique collaboration promise to provide new insights into the genetic factors that influence epilepsy, and will, perhaps, lead to a cure for this devastating neurological disorder. ..
  37. MEMBRANE MECHANISMS MEDIATING ALCOHOL INDUCED PATHOLOGY
    Richard Gross; Fiscal Year: 2001
    ..Collectively, the proposed research represents a multidisciplinary approach designed to dissect the biochemical mechanisms underlying these novel effects of ethanol and ethanol metabolites on hippocampal function. ..
  38. Axonal alterations in demyelinating diseases
    STEVEN SIMON SCHERER; Fiscal Year: 2011
    ..Aim #3: What Na,K-ATPase isoforms are expressed by myelinated axons and demyelinated axons? we will localize alpha1-3 by immunoelectron microscopy in CMSand PNS myelinated axons, along with their beta subunits. ..
  39. Molecular mechanisms of dendritic K channel function
    Lilian Yuan; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  40. SYNAPTIC TRANSMISSION DURING NEURONAL DIFFERENTIATION
    Kenna D Peusner; Fiscal Year: 2010
    ..As we learn more about the pathology induced by vestibular deafferentation at the level of vestibular nuclei neurons, effective therapies can be targeted selectively to improve the clinical management of patients with balance disorders. ..
  41. IONIC CONDUCTANCES AND CD4 LYMPHOCYTE DIFFERENTIATION
    Bruce Freedman; Fiscal Year: 2001
    ..The central hypothesis of this proposal is that the TCR-mediated calcium response regulates CD4plus lymphocyte differentiation, and that Kv channel regulate the secondary responses of differentiated cells to antigen. ..
  42. CHRONIC CORONARY OCCLUSION, EXERCISE TRAINING AND NO
    Cristine L Heaps; Fiscal Year: 2010
    ....
  43. HIV ENV & MACROPHAGE CHEMOKINE RECEPTOR IONIC SIGNALING
    Bruce Freedman; Fiscal Year: 2004
    ....
  44. TRINUCLEOTIDE REPEATS AND NEUROLOGIC DISEASE
    Russell Margolis; Fiscal Year: 2004
    ..Overall, the proposed experiments will enable a systematic test for CAG/CTG expansion mutations in a variety of devastating neurodegenerative diseases. ..
  45. The Role of Connexin32 in the Pathogenesis of CMTX
    Steven Scherer; Fiscal Year: 2006
    ....
  46. Advances in Renal Research: Human Diseases of Protein Processing
    David Ellison; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  47. Seizure resistance in zebrafish
    SCOTT BARABAN; Fiscal Year: 2009
    ..The results promise to provide new information about the genetics of seizure resistance and may lead to the design of novel anticonvulsant treatments designed to prevent epilepsy. ..
  48. Dendritic ion channel trafficking in plasticity
    Lilian Yuan; Fiscal Year: 2008
    ..Moreover, the studies proposed above represent our efforts to define the precise dendritic mechanisms involved in an animal model for human neurological diseases. [unreadable] [unreadable]..
  49. PHOSPHOLIPASE ACTIVATION AND MEMBRANE DYSFUNCTION IN DIABETIC CARDIOMYOPATHY
    Richard Gross; Fiscal Year: 2008
    ..More specifically, the proposed studies identify the chemical changes in hearts of diabetic patients that lead to altered heart function and ultimately to heart failure. [unreadable] [unreadable] [unreadable]..
  50. A Mouse Model of RNA-induced Neurotoxcity
    Russell Margolis; Fiscal Year: 2008
    ..Finding the points of pathogenic convergence in these diseases may provide novel leads for the development of rational therapeutics. ..
  51. MGE Progenitor Cell Grafts and Epilepsy
    SCOTT BARABAN; Fiscal Year: 2008
    ..abstract_text> ..