KRT8

Summary

Gene Symbol: KRT8
Description: keratin 8
Alias: CARD2, CK-8, CK8, CYK8, K2C8, keratin, type II cytoskeletal 8, cytokeratin-8, keratin 8, type II, type-II keratin Kb8
Species: human

Top Publications

  1. pmc APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process
    Carlo Vascotto
    Department of Biomedical Sciences and Technologies, University of Udine, P le Kolbe 4, 33100 Udine, Italy
    Mol Cell Biol 29:1834-54. 2009
  2. pmc Raf-1 activation disrupts its binding to keratins during cell stress
    Nam On Ku
    Department of Medicine, VA Palo Alto Medical Center, 3801 Miranda Ave, 154J, Palo Alto, CA 94304, USA
    J Cell Biol 166:479-85. 2004
  3. doi eIF3k regulates apoptosis in epithelial cells by releasing caspase 3 from keratin-containing inclusions
    Yu Min Lin
    Institute of Biochemical Sciences, National Taiwan University, Taiwan
    J Cell Sci 121:2382-93. 2008
  4. ncbi The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells
    R Moll
    Cell 31:11-24. 1982
  5. ncbi Identification of Mrj, a DnaJ/Hsp40 family protein, as a keratin 8/18 filament regulatory protein
    I Izawa
    Division of Biochemistry, Aichi Cancer Center Research Institute, Chikusa ku, Nagoya, Aichi 464 8681, Japan
    J Biol Chem 275:34521-7. 2000
  6. ncbi Keratin 8 mutations in patients with cryptogenic liver disease
    N O Ku
    Gastroenterology Section, Palo Alto Veterans Affairs Medical Center and Stanford University School of Medicine, Calif 94304, USA
    N Engl J Med 344:1580-7. 2001
  7. pmc Keratin attenuates tumor necrosis factor-induced cytotoxicity through association with TRADD
    H Inada
    Division of Biochemistry, Aichi Cancer Center Research Institute, Aichi 464 8681, Japan
    J Cell Biol 155:415-26. 2001
  8. ncbi Keratin 8 phosphorylation by p38 kinase regulates cellular keratin filament reorganization: modulation by a keratin 1-like disease causing mutation
    Nam On Ku
    Department of Medicine, and Geriatric Research, Education and Clinical Center, Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA
    J Biol Chem 277:10775-82. 2002
  9. ncbi Human keratin 8 mutations that disturb filament assembly observed in inflammatory bowel disease patients
    D W Owens
    Cancer Research UK Cell Structure Research Group, School of Life Science, University of Dundee, Dundee, DD1 5EH, UK
    J Cell Sci 117:1989-99. 2004
  10. ncbi Keratin 8 Y54H and G62C mutations are not associated with inflammatory bowel disease
    C Buning
    Department of Gastroenterology, Hepatology and Endocrinology, Universitatsmedizin Berlin, Charite, Campus Mitte, Schumannstrasse 20 21, D 10117 Berlin, Germany
    Dig Liver Dis 36:388-91. 2004

Research Grants

Detail Information

Publications305 found, 100 shown here

  1. pmc APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process
    Carlo Vascotto
    Department of Biomedical Sciences and Technologies, University of Udine, P le Kolbe 4, 33100 Udine, Italy
    Mol Cell Biol 29:1834-54. 2009
    ..Our data demonstrate that APE1 affects cell growth by directly acting on RNA quality control mechanisms, thus affecting gene expression through posttranscriptional mechanisms...
  2. pmc Raf-1 activation disrupts its binding to keratins during cell stress
    Nam On Ku
    Department of Medicine, VA Palo Alto Medical Center, 3801 Miranda Ave, 154J, Palo Alto, CA 94304, USA
    J Cell Biol 166:479-85. 2004
    ..Keratin-bound Raf kinase is released upon Raf hyperphosphorylation and activation during oxidative and other stresses...
  3. doi eIF3k regulates apoptosis in epithelial cells by releasing caspase 3 from keratin-containing inclusions
    Yu Min Lin
    Institute of Biochemical Sciences, National Taiwan University, Taiwan
    J Cell Sci 121:2382-93. 2008
    ....
  4. ncbi The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells
    R Moll
    Cell 31:11-24. 1982
  5. ncbi Identification of Mrj, a DnaJ/Hsp40 family protein, as a keratin 8/18 filament regulatory protein
    I Izawa
    Division of Biochemistry, Aichi Cancer Center Research Institute, Chikusa ku, Nagoya, Aichi 464 8681, Japan
    J Biol Chem 275:34521-7. 2000
    ..Taken together, these results suggest that Mrj may play an important role in the regulation of K8/18 filament organization as a K18-specific co-chaperone working together with Hsp/c70...
  6. ncbi Keratin 8 mutations in patients with cryptogenic liver disease
    N O Ku
    Gastroenterology Section, Palo Alto Veterans Affairs Medical Center and Stanford University School of Medicine, Calif 94304, USA
    N Engl J Med 344:1580-7. 2001
    ..We have previously described a mutation in the keratin 18 gene in a patient with cryptogenic cirrhosis, but the importance of mutations in the keratin 8 and keratin 18 genes in such patients is unclear...
  7. pmc Keratin attenuates tumor necrosis factor-induced cytotoxicity through association with TRADD
    H Inada
    Division of Biochemistry, Aichi Cancer Center Research Institute, Aichi 464 8681, Japan
    J Cell Biol 155:415-26. 2001
    ..These results indicate that K18 may sequester TRADD to attenuate interactions between TRADD and activated TNFR1 and moderate TNF-induced apoptosis in simple epithelial cells...
  8. ncbi Keratin 8 phosphorylation by p38 kinase regulates cellular keratin filament reorganization: modulation by a keratin 1-like disease causing mutation
    Nam On Ku
    Department of Medicine, and Geriatric Research, Education and Clinical Center, Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA
    J Biol Chem 277:10775-82. 2002
    ..Also, disease-causing keratin mutations can modulate keratin phosphorylation and organization, which may affect disease pathogenesis...
  9. ncbi Human keratin 8 mutations that disturb filament assembly observed in inflammatory bowel disease patients
    D W Owens
    Cancer Research UK Cell Structure Research Group, School of Life Science, University of Dundee, Dundee, DD1 5EH, UK
    J Cell Sci 117:1989-99. 2004
    ..Simple epithelial keratins may thus be considered as candidates for genes contributing to a risk of inflammatory bowel disease...
  10. ncbi Keratin 8 Y54H and G62C mutations are not associated with inflammatory bowel disease
    C Buning
    Department of Gastroenterology, Hepatology and Endocrinology, Universitatsmedizin Berlin, Charite, Campus Mitte, Schumannstrasse 20 21, D 10117 Berlin, Germany
    Dig Liver Dis 36:388-91. 2004
    ..Keratin 8 deficient mice display signs of colitis and diarrhoea characteristic for inflammatory bowel disease. Very recently, two keratin 8 mutations, Y54H and G62C, were identified...
  11. ncbi Epidermal abnormalities and increased malignancy of skin tumors in human epidermal keratin 8-expressing transgenic mice
    M Llanos Casanova
    Epithelial Damage, Repair and Tissue Engineering, CIEMAT, Avenida Complutense 22, 28040 Madrid, Spain
    FASEB J 18:1556-8. 2004
    ....
  12. ncbi Keratin 8 and 18 hyperphosphorylation is a marker of progression of human liver disease
    Diana M Toivola
    Department of Medicine, Palo Alto VA Medical Center, Stanford University School of Medicine Digestive Disease Center, Palo Alto, CA 94304, USA
    Hepatology 40:459-66. 2004
    ..In conclusion, site-specific keratin phosphorylation in liver disease is a progression marker when increased and a likely regression marker when decreased...
  13. pmc A disease- and phosphorylation-related nonmechanical function for keratin 8
    Nam On Ku
    Department of Medicine, Palo Alto VA Medical Center and Stanford University School of Medicine, Palo Alto, CA 94304, USA
    J Cell Biol 174:115-25. 2006
    ....
  14. ncbi Keratin 8 modulation of desmoplakin deposition at desmosomes in hepatocytes
    Anne Loranger
    Centre de Recherche en Cancerologie, QC, Canada G1R 2J6
    Exp Cell Res 312:4108-19. 2006
    ..Together, the data indicate that a proper alignment/deposition of desmoplakin with keratins and desmoglein in hepatocytes requires keratin 8, through a reciprocal phosphoserine-dependent process...
  15. ncbi Analysis of keratin polypeptides 8 and 19 variants in inflammatory bowel disease
    Guo Zhong Tao
    Department of Medicine, Palo Alto Veterans Affairs Medical Center and Stanford University Digestive Disease Center, Palo Alto, California 94304, USA
    Clin Gastroenterol Hepatol 5:857-64. 2007
    Keratin-8 (KRT8)-null mice develop spontaneous colitis and predisposition to liver injury...
  16. pmc Overexpression of cell surface cytokeratin 8 in multidrug-resistant MCF-7/MX cells enhances cell adhesion to the extracellular matrix
    Fang Liu
    State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, PR China
    Neoplasia 10:1275-84. 2008
    ..The molecular target of 9C6 was identified as cytokeratin 8 (CK8), which was found to be overexpressed on the cell surface of MCF-7/MX cells...
  17. doi Down-modulation of keratin 8 phosphorylation levels by PRL-3 contributes to colorectal carcinoma progression
    Eri Mizuuchi
    Department of Pathology, Division of Pathology, Kobe University Graduate School of Medicine, Kobe, Japan
    Int J Cancer 124:1802-10. 2009
    ..in wild type and C104S mutant PRL-3-transfected SW480 cells; the cytoskeletal intermediate filament keratin 8 (KRT8) was identified as a physiological PRL-3-interacting protein...
  18. pmc Keratin variants are overrepresented in primary biliary cirrhosis and associate with disease severity
    Bihui Zhong
    Division of Gastroenterology, First Affiliated Hospital of Sun Yat sen University, Guangzhou, China
    Hepatology 50:546-54. 2009
    ..Notably, keratin variants associated with disease severity (12.4% variants in Ludwig stage III/IV versus 4.2% in stages I/II; P < 0.04, odds ratio = 3.25, 95% confidence interval = 1.02-10.40), but not with the presence of AMA...
  19. pmc Keratin variants predispose to acute liver failure and adverse outcome: race and ethnic associations
    Pavel Strnad
    Department of Internal Medicine I, University Medical Center Ulm, Ulm, Germany
    Gastroenterology 139:828-35, 835.e1-3. 2010
    ..However, K8/K18 variant-associated susceptibility to acute liver injury, which is well-described in animal models, has not been studied in humans...
  20. pmc Keratin 8 phosphorylation regulates keratin reorganization and migration of epithelial tumor cells
    Tobias Busch
    Department of Internal Medicine I, University of Ulm, Ulm, Germany
    J Cell Sci 125:2148-59. 2012
    ....
  21. ncbi Phosphorylation of human keratin 8 in vivo at conserved head domain serine 23 and at epidermal growth factor-stimulated tail domain serine 431
    N O Ku
    Department of Medicine, Veterans Administration Palo Alto Health Care System, Palo Alto, California 94304, USA
    J Biol Chem 272:7556-64. 1997
    ..Furthermore, K8 Ser-431 phosphorylation occurs after EGF stimulation and during mitotic arrest and is likely to be mediated by mitogen-activated protein and cdc2 kinases, respectively...
  22. ncbi Stress, apoptosis, and mitosis induce phosphorylation of human keratin 8 at Ser-73 in tissues and cultured cells
    J Liao
    Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA
    J Biol Chem 272:17565-73. 1997
    ..The low steady state levels of HK8 during mitosis, in contrast to stress and apoptosis, suggest that accumulation of HK8 may represent a physiologic stress marker for simple epithelia...
  23. pmc Keratin 8 Y54H and G62C mutations are not associated with liver disease
    J Halangk
    J Med Genet 41:e92. 2004
  24. ncbi Implications of cytokeratin 8/18 filament formation in stratified epithelial cells: induction of transformed phenotype
    Ujwala Raul
    Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Cancer Research Institute, Kharghar, Navi Mumbai, India
    Int J Cancer 111:662-8. 2004
    ..human foetal buccal mucosa (FBM) cell line that expresses significantly higher amounts of CK18 compared to CK8. FBM cells were transfected with the full-length CK8 gene to study the role of CKs 8 and 18 in malignant ..
  25. ncbi Global proteomic approach unmasks involvement of keratins 8 and 18 in the delivery of cystic fibrosis transmembrane conductance regulator (CFTR)/deltaF508-CFTR to the plasma membrane
    Noélie Davezac
    INSERM U467, Faculte de Medecine Necker Enfants Malades, Paris, France
    Proteomics 4:3833-44. 2004
    ..A functional assay for CFTR revealed that specifically lowering K18 expression or changing its distribution leads to the delivery of functional deltaF508-CFTR to the plasma membrane. This work suggests a novel function of K18 in CF...
  26. pmc Negative regulation of the expressions of cytokeratins 8 and 19 by SLUG repressor protein in human breast cells
    Manish Kumar Tripathi
    Division of Cancer Biology, Department of Basic Sciences, Meharry Medical College, Nashville, TN 37208, USA
    Biochem Biophys Res Commun 329:508-15. 2005
    ..Inducible expression of SLUG in MDA-MB-468 cells inhibited the expressions of the cytokeratin 8 and 19 but not others as was revealed by microarray analysis...
  27. ncbi Keratins as susceptibility genes for end-stage liver disease
    Nam On Ku
    Department of Medicine, Palo Alto VA Medical Center, Palo Alto, California 94304, USA
    Gastroenterology 129:885-93. 2005
    ..Keratin 8 and 18 variants in 17 of 467 liver disease explants and 2 of 349 blood bank controls were previously reported in 5 analyzed exonic regions. We asked whether mutations were present in the remaining 10 exons of keratins 8 and 18...
  28. ncbi Keratin 8 sequence variants in patients with pancreatitis and pancreatic cancer
    Matthias Treiber
    Department of Hepatology and Gastroenterology, Charite, Campus Virchow Klinikum, Universitatsmedizin Berlin, Berlin, Germany
    J Mol Med (Berl) 84:1015-22. 2006
    Keratin 8 (KRT8) is one of the major intermediate filament proteins expressed in single-layered epithelia of the gastrointestinal tract...
  29. doi Cytokeratin 8 interacts with clumping factor B: a new possible virulence factor target
    M Haim
    Division of Molecular Dermatology, Department of Dermatology, University Hospital, Paracelsus Medical University, 5020 Salzburg, Austria
    Microbiology 156:3710-21. 2010
    ..We show that clumping factor B is capable of binding cytokeratin 8 (CK8), a type II cytokeratin...
  30. pmc Keratin hypersumoylation alters filament dynamics and is a marker for human liver disease and keratin mutation
    Natasha T Snider
    Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan 48109 5622, USA
    J Biol Chem 286:2273-84. 2011
    ..Hence, conformational changes induced by keratin natural mutations and extensive tissue injury result in K8/K18/K19 hypersumoylation, which retains keratins in an insoluble compartment, thereby limiting their cytoprotective function...
  31. pmc Non-coding keratin variants associate with liver fibrosis progression in patients with hemochromatosis
    Pavel Strnad
    Department of Internal Medicine I, University Medical Center Ulm, Ulm, Germany
    PLoS ONE 7:e32669. 2012
    ..Given the association of K8/K18 variants with end-stage liver disease and progression in several chronic liver disorders, we studied the importance of keratin variants in patients with hemochromatosis...
  32. ncbi Characterization of the binding sites for plasminogen and tissue-type plasminogen activator in cytokeratin 8 and cytokeratin 18
    K R Kralovich
    Department of Biochemistry and Molecular Genetics, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    J Protein Chem 17:845-54. 1998
    b>Cytokeratin 8 (CK8) is an intermediate filament protein that penetrates to the external surfaces of breast cancer cells and is released from cells in the form of soluble heteropolymers...
  33. ncbi The intermediate filament protein keratin 8 is a novel cytoplasmic substrate for c-Jun N-terminal kinase
    Tao He
    Turku Centre for Biotechnology, University of Turku and Abo Akademi University, the Department of Biochemistry and Pharmacy, Abo Akademi University, FIN 20521, Turku, Finland
    J Biol Chem 277:10767-74. 2002
    ..Taken together, K8 is a new cytoplasmic target for JNK in Fas receptor-mediated signaling. The functional significance of this phosphorylation could relate to regulation of JNK signaling and/or regulation of keratin dynamics...
  34. ncbi Interaction of zonula occludens-1 (ZO-1) with alpha-actinin-4: application of functional proteomics for identification of PDZ domain-associated proteins
    Vincent C Chen
    Department of Chemistry, University of Manitoba, Winnipeg, MB, R3T 2N2, Canada
    J Proteome Res 5:2123-34. 2006
    ....
  35. ncbi In vitro production of Mallory bodies and intracellular hyaline bodies: the central role of sequestosome 1/p62
    Conny Stumptner
    Institute of Pathology, Medical University of Graz, Graz, Austria
    Hepatology 46:851-60. 2007
    ....
  36. ncbi Organization and sequence of the human gene encoding cytokeratin 8
    S Krauss
    Institute of Cell and Tumor Biology, German Cancer Research Center, Heidelberg, F R G
    Gene 86:241-9. 1990
    Among the various intermediate filament (IF) proteins, cytokeratin 8 (CK8) is especially remarkable as it is produced early in embryogenesis, is the only type-II CK occurring in many simple epithelial cells, and can also be synthesized ..
  37. ncbi Immunotargeting with monoclonal cytokeratin 8 antibodies of human urothelial cancer transplanted to nude mice
    H Letocha
    Department of Oncology, University Hospital, Uppsala, Sweden
    Acta Oncol 32:793-800. 1993
    ..A monoclonal murine IgG antibody was raised against cytokeratin 8 and labelled with iodine-125; normal murine IgG was used for control purposes...
  38. ncbi Characterization of distinct early assembly units of different intermediate filament proteins
    H Herrmann
    German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, D 69120, Germany
    J Mol Biol 286:1403-20. 1999
    ..The number of molecules per filament cross-section, as deduced from the MPL values, was lowest for CK8/18, i.e. 16 and 25 at two seconds compared to 16 and 21 at one hour...
  39. ncbi Comparative analysis of alternative and traditional immunohistochemical markers for the distinction of ovarian sertoli cell tumor from endometrioid tumors and carcinoid tumor: A study of 160 cases
    Chengquan Zhao
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington, DC, USA
    Am J Surg Pathol 31:255-66. 2007
    ..Because traditional immunohistochemical markers [pan-cytokeratin (pan-CK), low molecular weight cytokeratin (CK8/18), epithelial membrane antigen (EMA), inhibin, calretinin, CD99, chromogranin, and synaptophysin] can ..
  40. doi Clinical, histopathologic, and immunohistochemical features of microglandular adenosis and transition into in situ and invasive carcinoma
    Ibrahim M Khalifeh
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Surg Pathol 32:544-52. 2008
    ..All tumors had strong and diffuse CK8/18 and EGFR expression but no estrogen receptor, progesterone receptor, HER2 (ie, triple negative), or CK5/6 ..
  41. ncbi Expression of the O-linked N-acetylglucosamine containing epitope H in normal myometrium and uterine smooth muscle cell tumors
    Markos N Sgantzos
    Department of Anatomy Histology Embryology, University of Thessaly Medical School, 22 Papakyriazi Street, Larissa 41222, Greece
    Pathol Res Pract 203:31-7. 2007
    ..The indirect immunoperoxidase method was applied using the mAbH and the monoclonal anti-cytokeratin 8 antibody (AbCK8) in 50 cases of typical uterine leiomyomas and in five cases of uterine leiomyosarcomas, with ..
  42. ncbi The possible role of cytokeratin 8 in cadmium-induced adaptation and carcinogenesis
    Andy T Y Lau
    Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, People s Republic of China
    Cancer Res 67:2107-13. 2007
    ..Interestingly, we showed that two intermediate filament proteins, cytokeratin 8 (CK8) and cytokeratin 14 (CK14), were increased significantly and stably maintained only in the adapted cells ..
  43. ncbi Expression of p53-related protein p63 in the gastrointestinal tract and in esophageal metaplastic and neoplastic disorders
    J N Glickman
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Hum Pathol 32:1157-65. 2001
    ..p63-positive cells in multilayered epithelium and in the mucosal gland duct epithelium were positive for CK8/18 (100%) and CK13 (67% and 30%, respectively) and negative for CK14 (0%), in contrast to p63-positive cells in ..
  44. ncbi Parachordoma: a case report
    R Separovic
    University Hospital for Tumors, Zagreb, Croatia
    Tumori 87:207-10. 2001
    ..Immunohistochemistry showed positive staining of the tumor cells with cytokeratin 8/18, S-100 protein and vimentin. The patient is well and without recurrence 20 months after surgery.
  45. doi Expression and distribution of intermediate-filament proteins and laminin during the development of the bovine Müllerian duct
    R A M Kenngott
    Lehrstuhl für Tieranatomie II, University of Munich, D 80539 Munich, Germany
    Anat Histol Embryol 37:223-30. 2008
    The expression pattern of several intermediate-filament proteins (vimentin, cytokeratin 8, 18 and 19) and the basal lamina component laminin was investigated in the Wolffian and the Müllerian ducts of bovine embryos and fetuses...
  46. ncbi Expression and distribution of cytokeratin 8/18 intermediate filaments in bovine antral follicles and corpus luteum: an intrinsic mechanism of resistance to apoptosis?
    David H Townson
    University of New Hampshire, Department of Molecular, Cellular and Biomedical Sciences, Durham, NH 03824, USA
    Histol Histopathol 25:889-900. 2010
    ..Specifically, cytokeratin 8/18 (CK8/18) filaments are thought to impart resistance to apoptosis...
  47. ncbi Small guanosine triphospatase RhoA and Rho-associated kinase as regulators of trophoblast migration
    Shigetatsu Shiokawa
    Department of Obstetrics and Gynecology, Kyorin University School of Medicine, Mitaka, Tokyo 181 8611, Japan
    J Clin Endocrinol Metab 87:5808-16. 2002
    ..The colocalization of RhoA, cytokeratin 8/18, and cytokeratin 7 in some cells located in the decidual stromal region indicated that extravillous ..
  48. ncbi Anomalous apical plasma membrane phenotype in CK8-deficient mice indicates a novel role for intermediate filaments in the polarization of simple epithelia
    N A Ameen
    Deptartment of Pediatrics, University of Miami School of Medicine, Miami, FL 33136, USA
    J Cell Sci 114:563-75. 2001
    ..In this work localization with anti-CK antibodies indicated that many Ck8-/- epithelia still form IF in CK8-deficient mice, perhaps because of the expression of the promiscuous CK7...
  49. ncbi Immunohistochemical study of basaloid squamous cell carcinoma, adenoid cystic and mucoepidermoid carcinoma in the upper aerodigestive tract
    H Tsubochi
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Anticancer Res 20:1205-11. 2000
    ..ACC and mucoepidermoid carcinoma were immunopositive for CK8, CK14 and CK17 and for CK8, CK14, CK17 and CK19, respectively...
  50. pmc Fungiform taste bud degeneration in C57BL/6J mice following chorda-lingual nerve transection
    Nick A Guagliardo
    Department of Psychology, University of Virginia, Charlottesville, Virginia 22904 4400, USA
    J Comp Neurol 504:206-16. 2007
    ..Fungiform taste buds were visualized and measured with the aid of cytokeratin 8. In control mice, taste buds were smaller and more abundant on the anterior tip (<1 mm) of the tongue...
  51. ncbi Isolation of genes differentially expressed between the Yoshida sarcoma and long-survival Yoshida sarcoma variants: origin of Yoshida sarcoma revisited
    H Tsuchiya
    Department of Experimental Pathology, Cancer Institute, Tokyo
    Jpn J Cancer Res 85:1099-104. 1994
    ..The mRNAs of the other six genes (those encoding for cytokeratin 8, cytokeratin18 (Endo B), TIMP2 and three unknown sequences) were not found in YS, but were present in LYs...
  52. ncbi Cytokeratin expression patterns in normal and malignant urothelium: a review of the biological and diagnostic implications
    J Southgate
    ICRF Cancer Medicine Research Unit, Research School of Medicine, St James s University Hospital, Leeds, UK
    Histol Histopathol 14:657-64. 1999
    ..The intensification of immunolabelling with some CK8 and CK18 antibodies may underly an active role in tumour invasion and foci of CK17-positive cells may represent ..
  53. ncbi Endolymphatic sac tumor associated with a von Hippel-Lindau disease patient: an immunohistochemical study
    H Horiguchi
    Department of Pathology, University of Tokushima School of Medicine, Kuramoto, Tokushima, Japan
    Mod Pathol 14:727-32. 2001
    ..2, 34betaE-12, CK7, CK8 and CK19), but not for CK10/13 or CK20...
  54. ncbi Characterization of epithelial cells derived from periodontal ligament by gene expression patterns of bone-related and enamel proteins
    Noriyoshi Mizuno
    Department of Periodontal Medicine, Division of Frontier Medical Science, Programs for Biomedical Research, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3, Kasumi, Minami Ku, Hiroshima 734 8553, Japan
    Cell Biol Int 29:111-7. 2005
    ..The mRNA expression patterns were determined by the reverse-transcription polymerase chain reaction (RT-PCR). Cytokeratin 8 mRNA was expressed by oral epithelial cells but not oral mesenchymal cells...
  55. doi Proteomic analyses of intermediate filaments reveals cytokeratin8 is highly acetylated--implications for colorectal epithelial homeostasis
    Siân H Leech
    Human Nutrition Unit, Division of Clinical Sciences North, University of Sheffield, Royal Hallamshire Hospital, Sheffield, UK
    Proteomics 8:279-88. 2008
    ..We report that CKs are highly acetylated in a colon cancer cell line, with five acetylation sites characterised on CK8 and a further one on CK18. Acetylation of CK8 is responsive to butyrate...
  56. doi Identification of six novel CC chemokines in gilthead seabream (Sparus aurata) implicated in the antiviral immune response
    A Cuesta
    Centro de Investigación en Sanidad Animal CISA INIA, Madrid, Spain
    Mol Immunol 47:1235-43. 2010
    ..have the highest identity, therefore we have designated the novel seabream CC chemokines as CK1, CK3, CK5, CK7, CK8 and CK10...
  57. ncbi [Clinicopathologic features of gallbladder adenocarcinoma with marked stromal fibrosis--a report of 19 cases]
    Yang Kun Wang
    Department of Pathology, The 150th Hospital of PLA, Luoyang, Henan, 471031, P R China
    Ai Zheng 25:896-900. 2006
    ..This research was to explore the clinicopathologic features of gallbladder adenocarcinoma with marked stromal fibrosis...
  58. ncbi Compensation of type I and type II cytokeratin pools in lung cancer
    Nobuhiro Kanaji
    First Department of Internal Medicine, Kagawa University, Kagawa, Japan
    Lung Cancer 55:295-302. 2007
    ..the largest family of intermediate filament proteins, and are subdivided into type I (CK9-CK23) and type II (CK1-CK8) subclasses...
  59. ncbi Diagnostic performance of the urinary bladder carcinoma antigen ELISA test and multiparametric DNA/cytokeratin flow cytometry in urine voided samples from patients with bladder carcinoma
    M Sanchez-Carbayo
    Servicio de Bioquimica, Hospital Universitario de Salamanca, Centro de Investigacion del Cancer Instituto mixto de Biologia Molecular y Celular del Cancer, Salamanca, Spain
    Cancer 92:2811-9. 2001
    ..of the current study was to comparatively analyze the sensitivity and specificity of flow cytometric DNA/cytokeratin 8/18 measurements and the urinary bladder carcinoma antigen (UBC) enzyme linked immunoabsorbent assay (ELISA) ..
  60. ncbi An immunohistochemical profile of giant cell carcinoma of the larynx
    Yesim Gurbuz
    Kocaeli University, Medical Faculty, Pathology Department, Kocaeli, Turkey
    Auris Nasus Larynx 34:413-6. 2007
    ..This report describes a case of a 62-year-old male with giant cell carcinoma of the larynx that presented as a neck mass and hoarseness...
  61. ncbi Cytokeratin 8/18 is a useful immunohistochemical marker for hepatocellular proliferative lesions in mice
    Masaomi Kawai
    Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, Tokyo 183 8509, Japan
    J Vet Med Sci 72:263-9. 2010
    ..and the livers were subjected to histological examinations on hematoxylin and eosin (HE) stained sections, CK8/18 immunohistochemistry and gamma-glutamyl transpeptidase (GGT) histochemistry...
  62. ncbi Immunohistochemical profile of common epithelial neoplasms arising in the kidney
    Mi Kyung Kim
    Department of Diagnostic Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Appl Immunohistochem Mol Morphol 10:332-8. 2002
    ..Both CD10 and VIM were predominantly expressed in CC and PC; E-CD in CPC, OC, and UC; CK7 in PC, CPC, and UC; CK8 and CK19 in CDC and UC; CK20 in UC; HCK in CDC and UC; and PL in CDC...
  63. ncbi P63 and cytokeratin8/18 expression in breast, atypical ductal hyperplasia, ductal carcinoma in situ and invasive duct carcinoma
    Maha M Shamloula
    The Department of Pathology, Faculty of Medicine, Tanta University
    J Egypt Natl Canc Inst 19:202-10. 2007
    ..This work was designed to study and compare the expression of p63 and cytokeratin 8/18 (CK8/18) in some cases of ADH, DCIS and IDC...
  64. ncbi Analysis of sensitivity and specificity of cytokeratin 19 reverse transcriptase/polymerase chain reaction for detection of occult breast cancer in bone marrow and leukapheresis products
    X Y Zhong
    Department of Obstetrics and Gynaecology, University Hospital, Heidelberg, Germany
    J Cancer Res Clin Oncol 125:286-91. 1999
    ..The work aimed to evaluate the sensitivity and specificity of the cytokeratin (CK) 19 reverse transcriptase/polymerase chain reaction (RT-PCR) for the detection of occult breast cancer in bone marrow and leukapheresis products...
  65. ncbi Expression patterns of ER-alpha, PR, HER-2/neu, and EGFR in different cell origin subtypes of high grade and non-high grade ductal carcinoma in situ
    Ping Tang
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Ave, Box 626, Rochester, New York 14642 USA
    Ann Clin Lab Sci 36:137-43. 2006
    ..Using a panel of antibodies to ER-alpha, PR, HER-2/neu, and EGFR, along with cytokeratin (CK) markers (CK5/6, CK8, CK14, CK17, and CK18), we found that all 3 cell origin subtypes can express ER-alpha and PR, and their expression ..
  66. pmc Genomic profiling of breast tumours in relation to BRCA abnormalities and phenotypes
    Olafur Andri Stefansson
    Faculty of Medicine, University of Iceland, Vatnsmyrarvegur 16, Reykjavik, Iceland
    Breast Cancer Res 11:R47. 2009
    ..Somatic mutations in BRCA1 and BRCA2 have not been found and the involvement of these genes in sporadic tumour development therefore remains unclear...
  67. ncbi Differential expression of cytokeratins 8 and 20 distinguishes craniopharyngioma from rathke cleft cyst
    Wei Xin
    Department of Pathology and the Comprehensive Cancer Center, University of Michigan Medical Center, Ann Arbor 48109, USA
    Arch Pathol Lab Med 126:1174-8. 2002
    ..Distinguishing craniopharyngioma from Rathke cleft cyst is sometimes difficult, and the distinction is clinically significant because Rathke cleft cysts have a better prognosis than craniopharyngiomas...
  68. ncbi [Expression of cytokeratins and ret in thyroid papillary carcinoma]
    Wei Xun Zhou
    Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
    Zhonghua Bing Li Xue Za Zhi 32:530-3. 2003
    ..To investigate the expression of cytokeratins and ret in thyroid papillary carcinoma (TPC) and their diagnostic value...
  69. ncbi Active Wnt signalling is associated with low differentiation and high proliferation in human biliary tract cancer in vitro and in vivo and is sensitive to pharmacological inhibition
    Tobias Kiesslich
    Department of Internal Medicine I, Paracelsus Medical University Salzburger Landeskliniken SALK, Muellner Hauptstrasse 48, 5020 Salzburg, Austria
    Int J Oncol 36:49-58. 2010
    ..Further investigation of the mechanism(s) of Wnt pathway activation and its inhibition may provide new molecular treatment strategies for biliary tract cancer...
  70. ncbi Histopathologic classification of lung cancer: Relevance of cytokeratin and TTF-1 immunophenotyping
    Leif Johansson
    Department of Pathology, University Hospital, Lund, Sweden
    Ann Diagn Pathol 8:259-67. 2004
    ..tumors had the "lung-specific" phenotype CK5-/TTF-1+; all small cell carcinomas had the phenotype CK5-/CK8+/TTF-1+, all adenocarcinomas CK5-/CK7+/TTF-1+ and (more than 50%) of LCC CK5-/CK7+/TTF-1+...
  71. pmc Posterior Hox gene expression and differential androgen regulation in the developing and adult rat prostate lobes
    Liwei Huang
    Department of Urology, University of Illinois at Chicago, 820 South Wood Street, Chicago, IL 60612, USA
    Endocrinology 148:1235-45. 2007
    ..expressing the Hoxb13 gene, NRP-152 cells cultured under nondifferentiating conditions exhibited robust cytokeratin 8 immunostain indicating that Hoxb13 expression drives luminal cell differentiation in the rat epithelium...
  72. doi Proteomic analysis of the major cellular proteins of bovine trophectoderm cell lines derived from IVP, parthenogenetic and nuclear transfer embryos: Reduced expression of annexins I and II in nuclear transfer-derived cell lines
    Neil C Talbot
    U S Department of Agriculture, Agricultural Research Service USDA, ARS, Animal and Natural Resources Institute, Animal Biosciences and Biotechnology Laboratory, Beltsville Agricultural Research Center, Beltsville, MD 20705 2350, United States
    Anim Reprod Sci 120:187-202. 2010
    ....
  73. doi Proteomic assays for the detection of urothelial cancer
    Kris E Gaston
    Department of Urology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit1373, Houston, TX 77030, USA
    Methods Mol Biol 641:303-23. 2010
    ..literature include bladder tumor antigen, nuclear matrix protein 22, BLCA-4, hyaluronic acid, hyaluronidase, cytokeratin 8, cytokeratin 18, cytokeratin 19, tissue polypeptide antigen, and tissue polypeptide-specific antigen...
  74. ncbi Primary intradural chordoma: report on three cases and review of the literature
    M Bergmann
    Department of Neuropathology, Klinikum Bremen Mitte, Bremen, Germany
    Clin Neuropathol 29:169-76. 2010
    ..Even rarer, intradural chordomas with a better biological behavior have also been reported. We present 3 further primary intradural extraosseous chordomas with a favorable clinical outcome...
  75. ncbi Cytokeratin expression patterns in the rat respiratory tract as markers of epithelial differentiation in inhalation toxicology. I. Determination of normal cytokeratin expression patterns in nose, larynx, trachea, and lung
    W K Schlage
    INBIFO Institut für biologische Forschung GmbH, Koln, Germany
    Toxicol Pathol 26:324-43. 1998
    ..Larynx: CK14, CK15 (basal, ciliated, nonciliated cells), CK8, CK18, CK19 (not in basal cells), CK4, and CK13 (cuboidal and squamoid cells of ventral half)...
  76. ncbi Identification of 5-fluorouracil response proteins in colorectal carcinoma cell line SW480 by two-dimensional electrophoresis and MALDI-TOF mass spectrometry
    Cesar Sze Chuen Wong
    Department of Clinical Oncology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, P R China
    Oncol Rep 20:89-98. 2008
    ..Protein identification indicated that cyclophilin A, cytokeratin 19 (CK19), cytokeratin 8 (CK8), ras-related nuclear protein, heat shock protein 27 (hsp27) and peroxiredoxin 6 (Prx 6) were upregulated ..
  77. ncbi Phenotypic evaluation of the basal-like subtype of invasive breast carcinoma
    Chad A Livasy
    Department of Pathology and Lab Medicine, University of North Carolina, Chapel Hill, NC 27599 7525, USA
    Mod Pathol 19:264-71. 2006
    ..for estrogen receptor (ER), HER2, EGFR, smooth muscle actin (SMA), p63, CD10, cytokeratin 5/6, cytokeratin 8/18, and vimentin was performed on 18 basal-like, 16 luminal, and 12 HER2+ tumors...
  78. ncbi [A new way for isolation and cultivation of sweat gland ductal cells from human split-thickness skin in vitro]
    Yong hong Lei
    Key Research Laboratory for Wound Repair and Regeneration, First Hospital Affiliated to the General Hospital of the People s Liberation Army, Beijing 100048, China
    Zhonghua Wai Ke Za Zhi 47:1574-7. 2009
    ..To explore a new method of isolation and culture of eccrine sweat gland ductal cells from human split-thickness skin graft in vitro...
  79. ncbi Expression of cytokeratins (CKs) 8, 13 and 18 and their mRNA in epithelial linings of radicular cysts: implication for the same CK profiles as nasal columnar epithelium in squamous epithelial lining
    D P Lu
    Department of Oral Surgery, Kochi Medical School, Kohasu, Japan
    Oral Dis 8:30-6. 2002
    ..Our objective was to specify cytokeratin (CK) patterns in lining epithelia of radicular cysts which are sometime lined with ciliated columnar epithelia as seen in the nasal epithelia...
  80. ncbi Cytokeratin 8 and 18 expression in imprint smears of chronic viral hepatitis, autoimmune hepatitis and hepatocellular carcinoma. A preliminary study
    Pauline Athanassiadou
    Cytology Unit, Pathology Laboratory, Medical School, Athens University, Greece
    Acta Cytol 51:61-5. 2007
    ..To investigate whether the expression of cytokeratin (CK) 8 and 18 is altered in chronic active viral hepatitis, autoimmune hepatitis and hepatocellular carcinoma...
  81. doi Immunohistochemical profiling of cytokeratin expression by endometrial stroma sarcoma
    Patrick A Adegboyega
    Department of Pathology and Feist Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    Hum Pathol 39:1459-64. 2008
    ..2 (CK8), CK19, CK20, and 34Ebeta12 (CK1, 5, 10, and 14)...
  82. doi Histopathological and molecular analysis of gastrectomy specimens from hereditary diffuse gastric cancer patients has implications for endoscopic surveillance of individuals at risk
    M E Barber
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge, UK
    J Pathol 216:286-94. 2008
    ..and evidence of epithelial-mesenchymal transition (EMT) was sought by immunohistochemistry for vimentin and cytokeratin 8/18. Four of eight patients had lesions detected at endoscopic surveillance. A median of 20...
  83. doi Cytokeratins 8 and 18 in adult human corneal endothelium
    Stanislava Merjava
    Laboratory of the Biology and Pathology of the Eye, Institute of Inherited Metabolic Disorders, General Teaching Hospital and First Faculty of Medicine, Charles University, Prague, Czech Republic
    Exp Eye Res 89:426-31. 2009
    ..were applied before indirect immunofluorescent or enzymatic staining was performed with antibodies against CK8 (Chemicon), CK18 (Dako and Sigma) and CK8/18 (Novocastra)...
  84. ncbi Immunocytochemical comparison of cultured normal epithelial prostatic cells with prostatic tissue sections
    O Cussenot
    Département de Recherche en Urologie, Hopital Saint Louis, Paris, France
    Exp Cell Res 214:83-92. 1994
    ..This cell type is the likely origin of prostatic neoplasia, with expression of CK8, 18, and 19 but not CK14...
  85. ncbi Cytokeratin expression patterns in the rat respiratory tract as markers of epithelial differentiation in inhalation toxicology. II. Changes in cytokeratin expression patterns following 8-day exposure to room-aged cigarette sidestream smoke
    W K Schlage
    INBIFO Institut für biologische Forschung GmbH, Koln, Germany
    Toxicol Pathol 26:344-60. 1998
    ..In the trachea only CK7 expression changed, and in the lung expression of CK7 (bronchioli) and CK8 (bronchus) changed; the expression of other CK polypeptides did not change...
  86. pmc Localization of a binding site for herpes simplex virus glycoprotein D on herpesvirus entry mediator C by using antireceptor monoclonal antibodies
    C Krummenacher
    Department of Microbiology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Virol 74:10863-72. 2000
    ..The anti-HveC V-domain MAbs CK6, CK8, and CK41, as well as the previously described MAb R1.302, blocked HSV entry...
  87. ncbi Cytokeratin 8 functions as a major plasminogen receptor in select epithelial and carcinoma cells
    S L Gonias
    Department of Pathology, University of Virginia School of Medicine, Charlottesville VA 22908, USA
    Front Biosci 6:D1403-11. 2001
    b>Cytokeratin 8 (K8) is a member of the intermediate filament (IF) gene family expressed by simple epithelial cells and by some carcinoma cells...
  88. ncbi Evaluation of multiparameter flow cytometry for the detection of breast cancer tumor cells in blood samples
    Ignacio Cruz
    Cytometry Service, University of Salamanca, Spain
    Am J Clin Pathol 123:66-74. 2005
    ..reactivity for up to 6 different anti-CK reagents using multiparameter FCM: anti-CK7, anti-CK20, anti-pan-CK, anti-CK8/CK18, anti-CK8, and anti-CK18...
  89. ncbi Antibodies against cytokeratin 8/18 in a patient with de novo autoimmune hepatitis after living-donor liver transplantation
    Ayano Inui
    Department of Pediatrics, International University of Health and Welfare, Atami Hospital, Japan
    Liver Transpl 11:504-7. 2005
    ..In conclusion, the changes in cytokeratin 8/18 in hepatocytes might be one of the sources of pathogenesis of de novo autoimmune hepatitis after liver ..
  90. ncbi Characterization of humanized liver from chimeric mice using coumarin as a human CYP2A6 and mouse CYP2A5 probe
    Kimiko Aoki
    Faculty of Pharmaceutical Sciences, Showa University, Tokyo, Japan
    Drug Metab Pharmacokinet 21:277-85. 2006
    ..The replacement % to human hepatocytes designated as replacement index (RI) was calculated from human specific cytokeratin 8/18 expression in the liver section. The COH activities correlated well with RIs in CM2 (R(2)=0...
  91. doi Eyelid multiple cysts of the apocrine gland of Moll in Persian cats
    Chiara Giudice
    Section of Veterinary Pathology, Department of Veterinary Pathology, Hygiene and Public Health, University of Milan, Via Celoria 10, 20133 Milan, Italy
    J Feline Med Surg 11:487-91. 2009
    ..Immunostaining was consistent with apocrine gland epithelium (cytokeratin 8/18; 19 and 14 positive). Ki67 immunolabelled nuclei ranged from 5.3 to 20.83%...
  92. doi Malignant adenomyoepithelioma of the breast combined with invasive lobular carcinoma
    Yumi Honda
    Department of Surgical Pathology, Kumamoto University Hospital, Kumamoto, Japan
    Pathol Int 59:179-84. 2009
    ..of cytokeratin (CK) 8/18-positive/CK5/6-positive/smooth muscle actin (SMA)-negative inner carcinoma cells and CK8/18-positive/CK5/6-positive/SMA-positive outer carcinoma cells...
  93. doi Isolation of genes involved in pancreas regeneration by subtractive hybridization
    Jong Ho Choi
    College of Medicine, CHA University, CHA General Hospital, Seoul 135 081, Korea
    Biol Chem 391:1019-29. 2010
    ..Twelve genes (adipsin, Aplp2, Clu, Col1a2, Glul, Krt8, Lgmn, LOC299907, LOC502894, Pla2g1b, Reg3α and Xbp1) were identified, and RT-PCR and real-time PCR analyses were ..
  94. doi Enhanced hepatic differentiation of mesenchymal stem cells after pretreatment with injured liver tissue
    Sadia Mohsin
    National Center of Excellence in Molecular Biology, 87 West Canal Bank Road, University of the Punjab, Lahore, Pakistan
    Differentiation 81:42-8. 2011
    ..were pretreated with injured liver tissue in an in-vitro model, which resulted in high expression of albumin, cytokeratin 8, 18, TAT and HNF1α as compared to untreated MSCs...
  95. doi Immunocytochemical localization of cytoplasmic and nuclear intermediate filaments in the bovine ovary during folliculogenesis
    J Wendl
    Lehrstuhl für Anatomie, Histologie und Embryologie, Department of Veterinary Sciences, LMU Munchen, Munich, Germany
    Anat Histol Embryol 41:190-201. 2012
    ..Using RT-PCR, specific transcripts for all intermediate proteins studied (CK8, CK18, desmin, vimentin, lamin A/C and lamin B1) were detected...
  96. pmc Circulating fibroblast-like cells in men with metastatic prostate cancer
    Michelle L Jones
    Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Prostate 73:176-81. 2013
    ..Based on this idea, we hypothesized that fibroblast-like cells, defined here as cytokeratin 8/18/19(-) /DAPI(+) /CD45(-) /vimentin(+) cells, are present in the blood of men with metastatic prostate cancer.
  97. pmc Generation of a novel MMTV-tTA transgenic mouse strain for the targeted expression of genes in the embryonic and postnatal mammary gland
    Kazuhito Sakamoto
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 7:e43778. 2012
    ..We show here that the MMTV-tTA can be used in combination with GFP reporter strains to visualize CK8/CK14-dual positive progenitors in newborn females and their derived basal and luminal epithelial cell lineages in ..
  98. pmc Primary cutaneous small cell carcinoma; a case report with differential diagnosis
    Tadashi Terada
    Department of Pathology, Shizuoka City Shimizu Hospital, Shimizu, Shizuoka, Japan
    Int J Clin Exp Pathol 6:1164-8. 2013
    ..Immunohistochemically, the tumor cells were positive for cytokeratin (CK) AE1/3, CK CAM5.2, CK34BE12, CD5, CD6, CK8, p63, NSE, NCAM, synaptophysin (focal), chromogranin (focal), p53, KIT, PDGFRA and Ki-67 (labeling index (LI)=86%)...
  99. doi In vitro hepatic differentiation of human endometrial stromal stem cells
    Xin Yuan Yang
    Departments of Gynecology and Obstetrics, First Affiliated Hospital, School of Medicine, Xi an Jiaotong University, Xi an, 710061, China
    In Vitro Cell Dev Biol Anim 50:162-70. 2014
    ..identified by their epithelial-like shape characteristics and expression of specific biomarkers albumin and cytokeratin 8 accompanied with a reduction of alpha-fetoprotein and alpha-smooth muscle actin expression...
  100. ncbi [Construction of a GFP/Puro double-labeled lentiviral vector containing CK8 interfering RNA and its effect on cell apoptosis in vitro]
    Yanchao Jin
    Department of Pharmaceutical Engineering, Tianjin University, Tianjin 300072, China E mail
    Nan Fang Yi Ke Da Xue Xue Bao 33:1761-5. 2013
    To construct a GFP/Puro double-labeled lentiviral expression vector for CK8 silencing and assess the effects of CK8 silencing on cell apoptosis.
  101. pmc Role of ursolic acid chalcone, a synthetic analogue of ursolic acid, in inhibiting the properties of CD133(+) sphere-forming cells in liver stem cells
    Rui xin Lin
    Department of Hepato Biliary Pancreatic Surgery, The Second Hospital of Jilin University Changchun 130041, China
    Int J Clin Exp Pathol 8:1427-34. 2015
    ..In addition it also decreased number of CK19-positive cells and increased number of CK8/18-positive cells...

Research Grants12

  1. Stem Cell Therapy for Hemophilia A
    Catherine Verfaillie; Fiscal Year: 2004
    ..Specific Aim 4: We will characterize the immune rejection fVIII following transplantation hfVIII transduced mMAPC in hemophilic mice. ..
  2. EARLY DETECT/CHARACTERIZATION OF TUMOR CELLS IN BLOOD
    Jonathan Uhr; Fiscal Year: 2001
    ....
  3. ANTIBODIES IN PATHOGENESIS OF AUTOIMMUNE NEUTROPENIA
    Henrik Ditzel; Fiscal Year: 2002
    ..3) Determine the pathogenesis of the cloned antibodies by generating intact human IgG1 antibodies from the cloned Fab fragments and testing for their ability to sensitize neutrophils by promoting ingestion by macrophages in vitro. ..
  4. ANTIBODIES IN PATHOGENESIS OF HIV-1 TROMBOCYTOPENIA
    Henrik Ditzel; Fiscal Year: 2003
    ..He will also look for molecular mimicry with foreign Ag's. ..
  5. Retinoids, RAMBAs, and Histone Deacetylase Inhibitors
    Vincent Njar; Fiscal Year: 2006
    ..The following specific aims that are proposed should enable us obtain substantial data that may support our hypothesis. ..
  6. THERAPEUTIC MODULATION OF BREAST CANCER ONCOGENES
    Christopher Benz; Fiscal Year: 2007
    ..tumor-targeted uptake of selected candidates by encapsulation into anti-ErbB2 immunoliposomes (ILs), and these ErbB2 receptor- and promoter-targeted ILs agents will be evaluated in vivo for further clinical development ..
  7. Biology of Breast Cancers Arising in Older Women
    Christopher Benz; Fiscal Year: 2007
    ..abstract_text> ..
  8. GENETIC ANALYSIS OF GBS ADHERENCE TO FIBRONECTIN
    GLEN TAMURA; Fiscal Year: 2002
    ..These studies will allow for identification of the structural gene(s) for fibronectin adhesin(s). ..
  9. Interactions of herpes simplex virus with nectin-1 at cell junctions
    Claude Krummenacher; Fiscal Year: 2008
    ..By identifying new requirements for virus entry in the host, this study will provide targets for novel therapeutic approaches to interfere with this process. [unreadable] [unreadable] [unreadable]..
  10. Targeting Nanoparticle DNA Delivery to Prostate Tumors
    Janet A Sawicki; Fiscal Year: 2010
    ....