KRIT1

Summary

Gene Symbol: KRIT1
Description: KRIT1, ankyrin repeat containing
Alias: CAM, CCM1, krev interaction trapped protein 1, ankyrin repeat-containing protein Krit1, cerebral cavernous malformations 1 protein, krev interaction trapped 1
Species: human

Top Publications

  1. ncbi Truncating mutations in CCM1, encoding KRIT1, cause hereditary cavernous angiomas
    S Laberge-le Couteulx
    INSERM U25, Faculte de Medecine Necker, 156 rue de Vaugirard, 75730 Paris Cedex 15, France
    Nat Genet 23:189-93. 1999
  2. ncbi Mutations in the gene encoding KRIT1, a Krev-1/rap1a binding protein, cause cerebral cavernous malformations (CCM1)
    T Sahoo
    Department of Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Hum Mol Genet 8:2325-33. 1999
  3. ncbi A novel KRIT1/CCM1 truncating mutation in a patient with cerebral and retinal cavernous angiomas
    Sophie Laberge Le Couteulx
    Faculté de Médecine Lariboisiere, Laboratoire de Génétique des Maladies Vasculaires, 10 Avenue de Verdun, EPI 99 21, 75010 Paris, Cedex, France
    Arch Ophthalmol 120:217-8. 2002
  4. ncbi Cerebral cavernous malformations: mutations in Krit1
    D J Verlaan
    Center for Research in Neurosciences, Montreal General Hospital, McGill University, Montreal, Quebec, Canada
    Neurology 58:853-7. 2002
  5. pmc Krit1 missense mutations lead to splicing errors in cerebral cavernous malformation
    Dominique J Verlaan
    Center for Research in Neurosciences, Montreal General Hospital, McGill University, 1650 Cedar Avenue, Montreal, Quebec, H3G 1A4, Canada
    Am J Hum Genet 70:1564-7. 2002
  6. pmc KRIT1, a gene mutated in cerebral cavernous malformation, encodes a microtubule-associated protein
    Murat Gunel
    Department of Neurosurgery, Yale Neurovascular Surgery Program, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 99:10677-82. 2002
  7. ncbi Mutation and expression analysis of the KRIT1 gene associated with cerebral cavernous malformations (CCM1)
    Hildegard Kehrer-Sawatzki
    Department of Human Genetics, University of Ulm, Albert Einstein Allee 11, 89081 Ulm, Germany
    Acta Neuropathol 104:231-40. 2002
  8. ncbi Krit1/cerebral cavernous malformation 1 mRNA is preferentially expressed in neurons and epithelial cells in embryo and adult
    C Denier
    INSERM EMI 99 21, Faculté de Médecine Lariboisiere, 10, avenue de Verdun, 75010 Paris, France
    Mech Dev 117:363-7. 2002
  9. ncbi CCM1 and CCM2 protein interactions in cell signaling: implications for cerebral cavernous malformations pathogenesis
    Jon S Zawistowski
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
    Hum Mol Genet 14:2521-31. 2005
  10. ncbi CCM2 expression parallels that of CCM1
    Askin Seker
    Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06510, USA
    Stroke 37:518-23. 2006

Research Grants

  1. Oregon CAM Course
    Edward Keenan; Fiscal Year: 2006
  2. Connective Tissue Mechanotransduction
    Helene M Langevin; Fiscal Year: 2012
  3. Use of Complementary and Alternative Medicine in Patient Management of Diabetes
    Robin R Whitebird; Fiscal Year: 2012
  4. Computer-based Patient Provider Communication about CAM Use
    WILLIAM Z TAN; Fiscal Year: 2011
  5. Isoform specific effects of the autoinhibitory element and the C-terminus of nitr
    JOHN SALERNO; Fiscal Year: 2009
  6. Jessica Casciano; Fiscal Year: 2014
  7. Paco S Herson; Fiscal Year: 2016
  8. Madeline A Shea; Fiscal Year: 2015
  9. RAZVAN LIVIU CORNEA; Fiscal Year: 2016
  10. Functional Consequences of FHC-linked RLC Mutations.
    Danuta Szczesna-Cordary; Fiscal Year: 2012

Detail Information

Publications420 found, 100 shown here

  1. ncbi Truncating mutations in CCM1, encoding KRIT1, cause hereditary cavernous angiomas
    S Laberge-le Couteulx
    INSERM U25, Faculte de Medecine Necker, 156 rue de Vaugirard, 75730 Paris Cedex 15, France
    Nat Genet 23:189-93. 1999
    ..Here we report a physical and transcriptional map of this interval and that CCM1, a gene whose protein product, KRIT1, interacts with RAP1A (also known as KREV1; ref...
  2. ncbi Mutations in the gene encoding KRIT1, a Krev-1/rap1a binding protein, cause cerebral cavernous malformations (CCM1)
    T Sahoo
    Department of Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Hum Mol Genet 8:2325-33. 1999
    ..Using a genomic sequence-based positional cloning strategy, we have identified KRIT1, encoding a protein that interacts with the Krev-1/rap1a tumor suppressor, as the CCM1 gene...
  3. ncbi A novel KRIT1/CCM1 truncating mutation in a patient with cerebral and retinal cavernous angiomas
    Sophie Laberge Le Couteulx
    Faculté de Médecine Lariboisiere, Laboratoire de Génétique des Maladies Vasculaires, 10 Avenue de Verdun, EPI 99 21, 75010 Paris, Cedex, France
    Arch Ophthalmol 120:217-8. 2002
  4. ncbi Cerebral cavernous malformations: mutations in Krit1
    D J Verlaan
    Center for Research in Neurosciences, Montreal General Hospital, McGill University, Montreal, Quebec, Canada
    Neurology 58:853-7. 2002
    To find mutations in the recently identified additional exons of the Krit1 gene that causes CCM1, a disease characterized by the formation of cerebral cavernous malformations (CCM)...
  5. pmc Krit1 missense mutations lead to splicing errors in cerebral cavernous malformation
    Dominique J Verlaan
    Center for Research in Neurosciences, Montreal General Hospital, McGill University, 1650 Cedar Avenue, Montreal, Quebec, H3G 1A4, Canada
    Am J Hum Genet 70:1564-7. 2002
    At least 40% of families affected with cerebral cavernous malformation have a mutation in Krit1. We previously identified two point mutations in Krit1 leading to changes in amino acids (D137G and Q210E) in two different families...
  6. pmc KRIT1, a gene mutated in cerebral cavernous malformation, encodes a microtubule-associated protein
    Murat Gunel
    Department of Neurosurgery, Yale Neurovascular Surgery Program, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 99:10677-82. 2002
    Mutations in Krev1 interaction trapped gene 1 (KRIT1) cause cerebral cavernous malformation, an autosomal dominant disease featuring malformation of cerebral capillaries resulting in cerebral hemorrhage, strokes, and seizures...
  7. ncbi Mutation and expression analysis of the KRIT1 gene associated with cerebral cavernous malformations (CCM1)
    Hildegard Kehrer-Sawatzki
    Department of Human Genetics, University of Ulm, Albert Einstein Allee 11, 89081 Ulm, Germany
    Acta Neuropathol 104:231-40. 2002
    ..In patients with cavernomas, constitutional mutations of the KRIT1 gene have been identified...
  8. ncbi Krit1/cerebral cavernous malformation 1 mRNA is preferentially expressed in neurons and epithelial cells in embryo and adult
    C Denier
    INSERM EMI 99 21, Faculté de Médecine Lariboisiere, 10, avenue de Verdun, 75010 Paris, France
    Mech Dev 117:363-7. 2002
    ..Three CCM loci have been mapped, and the sole gene identified so far, CCM1, has been shown to encode KRIT1, a protein of unknown function...
  9. ncbi CCM1 and CCM2 protein interactions in cell signaling: implications for cerebral cavernous malformations pathogenesis
    Jon S Zawistowski
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
    Hum Mol Genet 14:2521-31. 2005
    ..Familial CCM is caused by mutations in KRIT1 (CCM1) or in malcavernin (CCM2), the murine ortholog of which was concurrently characterized as osmosensing ..
  10. ncbi CCM2 expression parallels that of CCM1
    Askin Seker
    Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06510, USA
    Stroke 37:518-23. 2006
    ..Mutations in CCM2 (MGC4607 or malcavernin) cause familial cerebral cavernous malformation (CCM), an autosomal dominant neurovascular disease. Both the function of this molecule and the pathogenesis of the disease remain elusive...
  11. ncbi Identification of two novel mutations and of a novel critical region in the KRIT1 gene
    Vito Guarnieri
    Medical Genetics Service, Poliambulatorio Giovanni Paolo II, IRCCS Casa Sollievo della Sofferenza Hospital, Viale Cappuccini, 71013, San Giovanni Rotondo FG, Italy
    Neurogenetics 8:29-37. 2007
    ..Mutations in three genes (KRIT1, MGC4607, and PDCD10) have been associated with CCMs...
  12. ncbi Highly variable penetrance in subjects affected with cavernous cerebral angiomas (CCM) carrying novel CCM1 and CCM2 mutations
    Fernando Gianfrancesco
    Institute of Genetics and Biophysics, Italian National Research Council, Naples, Italy
    Am J Med Genet B Neuropsychiatr Genet 144:691-5. 2007
    ..origin and investigating the genetic basis of the disorder we disclosed two novel molecular variations in the KRIT1 and MGC4607 genes...
  13. ncbi CCM3 interacts with CCM2 indicating common pathogenesis for cerebral cavernous malformations
    Katrin Voss
    Department of Human Genetics, University of Wurzburg, Biozentrum, Am Hubland, 97074 Wurzburg, Germany
    Neurogenetics 8:249-56. 2007
    Individuals carrying a mutation in one of the three cerebral cavernous malformation genes (CCM1/KRIT1, CCM2, CCM3) cannot be clinically distinguished, raising the possibility that they act within common molecular pathways...
  14. pmc Krit 1 interactions with microtubules and membranes are regulated by Rap1 and integrin cytoplasmic domain associated protein-1
    Sophie Béraud-Dufour
    UMR 6097 CNRS UNSA, Institut de Pharmacologie Moleculaire et Cellulaire, Vabonne, France
    FEBS J 274:5518-32. 2007
    ..b>Krev interaction trapped 1 (Krit1), a protein with FERM (band four-point-one/ezrin/radixin/moesin) domain, was identified as a Rap1 ..
  15. pmc KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell cell junctions
    Angela Glading
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Cell Biol 179:247-54. 2007
    ..malformation (CCM), a disease associated with defective endothelial junctions, result from autosomal dominant CCM1 mutations that cause loss of KRIT-1 protein function, though how the loss of KRIT-1 leads to CCM is obscure...
  16. doi Novel CCM1, CCM2, and CCM3 mutations in patients with cerebral cavernous malformations: in-frame deletion in CCM2 prevents formation of a CCM1/CCM2/CCM3 protein complex
    Sonja Stahl
    Department of Human Genetics, University of Wurzburg, Wurzburg, Germany
    Hum Mutat 29:709-17. 2008
    ..a combination of direct sequencing and MLPA analyses, we identified 15 novel and eight previously published CCM1 (KRIT1), CCM2, and CCM3 (PDCD10) mutations...
  17. doi Krit1 modulates beta 1-integrin-mediated endothelial cell proliferation
    Jun Zhang
    Department of Neurosurgery, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    Neurosurgery 63:571-8; discussion 578. 2008
    Using ribonucleic acid interference on cultured cell lines, we examined the role of Krev interaction trapped 1 (krit1) and integrin cytoplasmic domain-associated protein-1 alpha (icap1alpha) in beta1-integrin-mediated cell proliferation.
  18. pmc Biallelic somatic and germline mutations in cerebral cavernous malformations (CCMs): evidence for a two-hit mechanism of CCM pathogenesis
    Amy L Akers
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
    Hum Mol Genet 18:919-30. 2009
    ..Familial cases follow autosomal-dominant inheritance due to mutations in one of three genes, CCM1/KRIT1, CCM2/malcavernin or CCM3/PDCD10...
  19. pmc A two-hit mechanism causes cerebral cavernous malformations: complete inactivation of CCM1, CCM2 or CCM3 in affected endothelial cells
    Axel Pagenstecher
    Department of Neuropathology, University of Marburg, Germany
    Hum Mol Genet 18:911-8. 2009
    ..Familial cerebral cavernous malformations (CCMs) have been associated with germline mutations in CCM1/KRIT1, CCM2 or CCM3/PDCD10...
  20. doi Molecular screening test in familial forms of cerebral cavernous malformation: the impact of the Multiplex Ligation-dependent Probe Amplification approach
    Silvana Penco
    Department of Laboratory Medicine, Medical Genetics, Niguarda Ca Granda Hospital Milano, Piazza Ospedale Maggiore 3, 20162 Milan, Italy
    J Neurosurg 110:929-34. 2009
    ..Ligation-dependent Probe Amplification analysis integrates the consecutive sequence analysis of the 3 genes (Krit1/CCM1, MGC4607/CCM2, and PDCD10/CCM3) known to be responsible for cerebral cavernous malformation lesions...
  21. doi Frequency and phenotypes of cutaneous vascular malformations in a consecutive series of 417 patients with familial cerebral cavernous malformations
    J Sirvente
    Department of Neurology CHU Caremeau, Nimes, France
    J Eur Acad Dermatol Venereol 23:1066-72. 2009
    ..Three genes (KRIT1/CCM1, MGC4607/CCM2, PDCD10/CCM3) have been identified so far...
  22. doi CCM1 regulates vascular-lumen organization by inducing endothelial polarity
    Maria Grazia Lampugnani
    IFOM, FIRC Institute of Molecular Oncology Foundation, 20139 Milan, Italy
    J Cell Sci 123:1073-80. 2010
    ..b>CCM1 is encoded by the CCM1 gene, which is mutated in 60% of patients affected by cerebral cavernous malformation (CCM)...
  23. pmc KRIT1 regulates the homeostasis of intracellular reactive oxygen species
    Luca Goitre
    Molecular Biotechnology Centre, Department of Genetics, Biology and Biochemistry, University of Torino, Torino, Italy
    PLoS ONE 5:e11786. 2010
    b>KRIT1 is a gene responsible for Cerebral Cavernous Malformations (CCM), a major cerebrovascular disease characterized by abnormally enlarged and leaky capillaries that predispose to seizures, focal neurological deficits, and fatal ..
  24. doi Mutation analysis of CCM1, CCM2 and CCM3 genes in a cohort of Italian patients with cerebral cavernous malformation
    Rosalia D'Angelo
    Department of Biomorphology and Biotechnologies, University of Messina, Italy
    Brain Pathol 21:215-24. 2011
    ..Familial cases are associated with mutations in CCM1[K-Rev interaction trapped 1 (KRIT1)], CCM2 (MGC4607) and CCM3 (PDCD10) genes...
  25. pmc A mechanism of Rap1-induced stabilization of endothelial cell--cell junctions
    Jian J Liu
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Mol Biol Cell 22:2509-19. 2011
    ..of Rap1 small GTPases stabilizes cell--cell junctions, and this activity requires Krev Interaction Trapped gene 1 (KRIT1)...
  26. ncbi Association of Krev-1/rap1a with Krit1, a novel ankyrin repeat-containing protein encoded by a gene mapping to 7q21-22
    I Serebriiskii
    Division of Basic Sciences, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Oncogene 15:1043-9. 1997
    ..multiple isolates coding for a previously undescribed protein which we have designated Kritl (for Krev Interaction Trapped 1)...
  27. ncbi KRIT1 is mutated in hyperkeratotic cutaneous capillary-venous malformation associated with cerebral capillary malformation
    I Eerola
    Laboratory of Human Molecular Genetics, Institute of Cellular Pathology ICP and Université Catholique de Louvain UCL, Avenue Hippocrate 75 4, B 1200 Brussels, Belgium
    Hum Mol Genet 9:1351-5. 2000
    ..The first mutations were identified in the CCM1 gene (located on 7q21-22), which encodes KRIT1 protein (KREV1 interaction trapped 1), presumably a membrane-bound protein with signalling activity...
  28. ncbi Computational and experimental analyses reveal previously undetected coding exons of the KRIT1 (CCM1) gene
    T Sahoo
    Department of Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genomics 71:123-6. 2001
    ..An important such case has been found with KRIT1, the cerebral cavernous malformation type 1 (CCM1) gene...
  29. ncbi Interaction between krit1 and icap1alpha infers perturbation of integrin beta1-mediated angiogenesis in the pathogenesis of cerebral cavernous malformation
    J Zhang
    Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Hum Mol Genet 10:2953-60. 2001
    ..b>Krev Interaction Trapped 1 (krit1) was originally identified through its interaction with the Ras-family GTPase krev1/rap1a in a ..
  30. ncbi KRIT1 association with the integrin-binding protein ICAP-1: a new direction in the elucidation of cerebral cavernous malformations (CCM1) pathogenesis
    Jon S Zawistowski
    Department of Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Hum Mol Genet 11:389-96. 2002
    Mutations in KRIT1, a protein initially identified based on a yeast two-hybrid interaction with the RAS-family GTPase RAP1A, are responsible for the development of the inherited vascular disorder cerebral cavernous malformations (CCM1)...
  31. ncbi Molecular genetic investigations in the CCM1 gene in sporadic cerebral cavernomas
    P Reich
    Neurooncological Laboratory of the Department of Neurosurgery, Klinikum Grosshadern Ludwig Maximilians University, Munich, Germany
    Neurology 60:1135-8. 2003
    ..Mutations in Krit1, a gene located at the CCM1 locus on chromosome 7q21, account for the majority of familial CCM cases...
  32. ncbi KRIT1/cerebral cavernous malformation 1 protein localizes to vascular endothelium, astrocytes, and pyramidal cells of the adult human cerebral cortex
    Ozlem Guzeloglu-Kayisli
    Neurovascular Surgery Program, Department of Neurosurgery, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Neurosurgery 54:943-9; discussion 949. 2004
    Mutations in KRIT1 cause familial cerebral cavernous malformation, an autosomal dominant disorder affecting primarily the central nervous system vasculature...
  33. ncbi CCM1 mutation screen of sporadic cases with cerebral cavernous malformations
    D J Verlaan
    Center for Research in Neurosciences and Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
    Neurology 62:1213-5. 2004
    ..The CCM1 gene was screened in 35 sporadic cases with either single or multiple CCM...
  34. ncbi Biallelic somatic and germ line CCM1 truncating mutations in a cerebral cavernous malformation lesion
    Judith Gault
    Department of Neurosurgery, University of Colorado Health Sciences Center, Denver, Colo, USA
    Stroke 36:872-4. 2005
    ..CCMs are sporadic or inherited and 3 genes (CCM1, CCM2, and CCM3) have been identified. However, the role of somatic mutation in CCM genesis has been disputed...
  35. ncbi Frequency of retinal cavernomas in 60 patients with familial cerebral cavernomas: a clinical and genetic study
    Pierre Labauge
    Department of Neurology, Centre Hospitalo Universitaire de Montpellier Nîmes, Montpellier, France
    Arch Ophthalmol 124:885-6. 2006
    ..To define the frequency of retinal lesions in a large panel of patients with familial cerebral cavernomas and to screen the cerebral cavernous malformation genes in patients with cerebral and retinal lesions...
  36. ncbi A splice-site mutation in CCM1/KRIT1 is associated with retinal and cerebral cavernous hemangioma
    Anna S Kitzmann
    Department of Ophthalmology, Mayo Clinic, Rochester, MN 55905, USA
    Ophthalmic Genet 27:157-9. 2006
    To report a case of a unilateral retinal cavernous hemangioma associated with a novel splice-site mutation in CCM1/KRIT1.
  37. ncbi Interaction between krit1 and malcavernin: implications for the pathogenesis of cerebral cavernous malformations
    Jun Zhang
    Department of Neurological Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Neurosurgery 60:353-9; discussion 359. 2007
    ..Mutations in krit1 and malcavernin, the proteins encoded by the genes at the CCM1 and CCM2 loci, respectively, are responsible for ..
  38. pmc Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity
    Rebecca A Stockton
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Exp Med 207:881-96. 2010
    ..malformations (CCMs) in humans result from mutations of CCM2 (malcavernin, OSM, MGC4607), PDCD10 (CCM3), or KRIT1 (CCM1), a Rap1 effector which stabilizes endothelial cell-cell junctions...
  39. pmc Cerebral cavernous malformation protein CCM1 inhibits sprouting angiogenesis by activating DELTA-NOTCH signaling
    Joycelyn Wüstehube
    Vascular Biology and Tumor Angiogenesis, Medical Faculty Mannheim, Heidelberg University, D 68167 Mannheim, Germany
    Proc Natl Acad Sci U S A 107:12640-5. 2010
    ..CCM1 (also known as KRIT1) stabilizes endothelial junctions and is essential for vascular morphogenesis in mouse embryos...
  40. doi Genomic causes of multiple cerebral cavernous malformations in a Japanese population
    Satoshi Tsutsumi
    Department of Neurological Surgery, Juntendo University Urayasu Hospital, 2 1 1 Tomioka, Urayasu, Chiba 279 0021, Japan
    J Clin Neurosci 20:667-9. 2013
    ..of CCM are thought to arise in association with genomic mutations in the cerebral cavernous malformation 1 (CCM1) (KRIT1), CCM2 (MGC4607), and CCM3 (PDCD10) genes...
  41. ncbi Cloning of the murine Krit1 cDNA reveals novel mammalian 5' coding exons
    J Zhang
    Howard Hughes Medical Institute and The Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Genomics 70:392-5. 2000
    Human KRIT1 (Krev interaction trapped 1), a defective gene product in cerebral cavernous malformation, was cloned from a HeLa cell cDNA library by virtue of its interaction with Krev/rap1A, a small ras-family GTPase...
  42. ncbi [Clinical and bacteriological studies on hospital outbreak of Salmonella enteritidis food poisoning]
    Y Dohtsu
    Department of Medicine, Nagasaki Municipal Hospital
    Kansenshogaku Zasshi 75:110-5. 2001
    ..In vitro, S. Enteritidis were sensitive to OFLX, TFLX, FOM, most of PCs, CEPs, AGs but resistant to MPIPC, CAM, CLDM, VCM...
  43. ncbi [Inhibition of biofilm formation by clarithromycin (CAM) in an experimental model of complicated bladder infection--in vitro study using automated simulation of urinary antimicrobial concentration]
    M Sano
    Department of Urology, Sapporo Medical University, School of Medicine
    Kansenshogaku Zasshi 68:1306-17. 1994
    The role of clarithromycin (CAM) in biofilm formation has recently been reported...
  44. ncbi Adhesion molecules and their role in vascular disease
    C F Krieglstein
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, USA
    Am J Hypertens 14:44S-54S. 2001
    ..These cell adhesion molecules (CAM) are known to mediate blood cell (leukocyte, platelet)-endothelial cell interactions that can occur in all segments ..
  45. pmc Evidence that nitric oxide is an endogenous antiangiogenic mediator
    E Pipili Synetos
    Department of Pharmacology, Medical School, University of Patras, Greece
    Br J Pharmacol 111:894-902. 1994
    ..oxide (NO) in the regulation of angiogenesis was examined in the in vivo system of the chorioallantoic membrane (CAM) of the chick embryo and in the matrigel tube formation assay. 2. Sodium nitroprusside (SNP) (0...
  46. pmc Investigations of the dual contractile/relaxant properties showed by antioquine in rat aorta
    M D Ivorra
    Departamento de Farmacologia, Facultad de Farmacia, Universidad de Valencia, Spain
    Br J Pharmacol 109:502-9. 1993
    ..6. Antioquine weakly inhibited some PDE forms isolated from bovine aorta: a CaM-PDE (PDE I)which preferentially hydrolyzes cyclic GMP and is activated by calmodulin, and a rolipram-sensitive ..
  47. ncbi [Tumor markers in the diagnosis of pancreatic cancer]
    G Cappelli
    U.O. Medicina Nucleare, Azienda Ospedaliera Careggi, Firenze, Italia
    Tumori 85:S19-21. 1999
    ..Recently other two mucines are emploied CA 242 and CAM 17.1 but they are not better than CA 19-9...
  48. ncbi Capacity of enzymes of the euphorbiacea Aleurites montana involved in CO2-fixation, compared to plants having C3-, C4- and Crassulacean acid metabolism
    N Grotjohann
    , , , Bundesrepublik Deutschland
    Z Naturforsch C 55:383-91. 2000
    ..For comparison Bryophyllum daigremontiana (CAM). Saccharum officinarum (C4) and Capsicum frutescens (C3) were treated in the same way...
  49. ncbi Myoepithelial carcinoma arising in a benign myoepithelioma: immunohistochemical, ultrastructural, and flow-cytometrical study
    J A Bombi
    Department of Pathology, Universitat de Barcelona, Spain
    Ultrastruct Pathol 20:145-54. 1996
    ..were similar for the benign and malignant tumors, with positivity for S-100 protein, vimentin, cytokeratins, and CAM 5.2, and were negative for GFAP, muscle-specific actin, CEA, and desmin...
  50. ncbi Pleural mesothelioma presenting as an axillary lymph node metastasis with anemone cell appearance
    J Lloreta
    Servei de Patologia, Hospital Universitari del Mar, Barcelona, Spain
    Ultrastruct Pathol 18:293-8. 1994
    ..Tumor cells in the present case were positive for cytokeratins (Cam 5...
  51. ncbi Molecular pharmacology of calcium, calmodulin-dependent myosin phosphorylation in vascular smooth muscle
    T Ishikawa
    Department of Pharmacology, Nagoya University School of Medicine, Japan
    Am J Hypertens 3:231S-234S. 1990
    The Ca2+, calmodulin (CaM)-dependent phosphorylation of the 20 kDa myosin light chain (LC20) is accepted as an important component of the regulatory mechanism in smooth muscle contraction...
  52. ncbi Immunohistochemical features of giant cell carcinoma of the lung: patterns of expression of cytokeratins, vimentin, and the mucinous glycoprotein recognized by monoclonal antibody A-80
    G Chejfec
    Department of Pathology, Hines VA Hospital Loyola University School of Medicine, Maywood, Illinois
    Ultrastruct Pathol 15:131-8. 1991
    ..of monoclonal antibodies (Mabs) recognizing different cytokeratin polypeptides (AE1, AE3, AE1/AE3 cocktail, and CAM 5...
  53. ncbi [Effect of macrolide antibiotics on human serum-bactericidal sensitivity of Pseudomonas aeruginosa S-6]
    K Tateda
    Department of Microbiology, Toho University School of Medicine
    Kansenshogaku Zasshi 65:1337-43. 1991
    ..01). Of other macrolide antibiotics used, clarithromycin (CAM) also increased the serum-bactericidal sensitivity of P...
  54. ncbi Bacterial biofilm in chronic airway infection
    N Ohgaki
    First Department of Internal Medicine, Kyorin University, School of Medicine
    Kansenshogaku Zasshi 68:138-51. 1994
    ..aeruginosa. Additionally, the effects of clarithromycin (CAM) on biofilm bacteria were studied in order to investigate new therapeutic maneuvers against a bacterial biofilm...
  55. ncbi [Pathogenesis of the neuronal migration disorder, with special reference to the animal model of prenatal exposure to low-dose ionizing radiation]
    S Fushiki
    Department of Dynamic Pathology, Kyoto Prefectural University of Medicine
    No To Hattatsu 29:102-7. 1997
    ..of cortical neurons during the embryonic period together with a changed pattern of cell adhesion molecule, N-CAM. In addition, the effect of radiation remained at least up until 3-week postnatal as disorganized neuronal ..
  56. ncbi A CAD-CAM methodology to produce bone-remodelled composite femurs for preclinical investigations
    V Waide
    Laboratorio di Tecnologia Medica, Istituti Ortopedici Rizzoli, Bologna, Italy
    Proc Inst Mech Eng H 215:459-69. 2001
    ..This work describes the use of computer aided design/manufacturing methods (CAD-CAM) to produce these specimens, based on modifying commercially available composite femurs...
  57. ncbi Erythrocyte adducin differential properties in the normotensive and hypertensive rats of the Milan strain. Characterization of spleen adducin m-RNA
    S Salardi
    Farmitalia Carlo Erba Istituto Richerche, Nerviano, Italy
    Am J Hypertens 2:229-37. 1989
    ..with the recently described cytoskeletal protein adducin on the following bases: the protein binds calmodulin (CaM) and protein kinase C (PKc) in a Ca2+ dependent way...
  58. ncbi Increase of calmodulin activator in hypertension. Modulation by dietary sodium and calcium
    E Chang
    Clinical Research Institute of Montreal, Quebec, Canada
    Am J Hypertens 3:210S-215S. 1990
    ..BP) in normotensive rats (Wistar, WKY), spontaneously hypertensive rats (SHR) and Dahl rats and on calmodulin (CaM) activator, a newly-discovered hydrophobic compound that increases CaM activity in SHR and spontaneously ..
  59. ncbi Atypical carcinoid tumor of the larynx: an immunohistochemical, ultrastructural, and flow cytometric analysis
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    Ultrastruct Pathol 21:431-8. 1997
    ..revealed focal intracytoplasmic mucin accumulation, and immunohistochemistry showed the tumors to be positive for CAM 5.2, CEA, chromogranin A, and calcitonin...
  60. pmc Spin-labeling studies of the conformation of the Ca(2+)-regulatory protein calmodulin in solution and bound to the membrane skeleton in erythrocyte ghosts: implications to transmembrane signaling
    M A Yacko
    Department of Chemistry, University of Kentucky, Lexington 40506 0055
    Biophys J 63:317-22. 1992
    Electron paramagnetic resonance (EPR) studies of the Ca(2+)-regulatory protein calmodulin (CaM) have been performed...
  61. ncbi Atypical tumor of the mediastinum: epithelioid hemangioendothelioma containing metaplastic bone and osteoclastlike giant cells
    N Weidner
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115
    Ultrastruct Pathol 15:481-8. 1991
    ..epithelioid cells also stained for muscle-specific actin (HHF-35), yet were negative for desmin and cytokeratins (CAM 5.2 and AE1/3). The findings were most consistent with those reported to occur in epithelioid hemangioendothelioma.
  62. ncbi [Adaptation study for biofilm of the urinary tract via highly complicated bladder model (biofilm model of the urinary tract)--experimental study using automatic simulator of the urinary antimicrobial agent concentration]
    M Sano
    Department of Urology, Sapporo Medical University, School of Medicine
    Kansenshogaku Zasshi 68:894-904. 1994
    ..Clarithromycin (CAM), which is reported to have an anti-biofilm action, was examined at urinary levels approximating clinical ..
  63. ncbi Pioglitazone and metformin reverse insulin resistance induced by tumor necrosis factor-alpha in liver cells
    S S Solomon
    Research Service, VAMC, Memphis, USA
    Horm Metab Res 29:379-82. 1997
    ..E cells with graded doses of TNF-alpha and measured the ability of insulin (INS) to stimulate both calmodulin (CaM) mRNA and glucose utilization...
  64. ncbi [Therapeutic study on biofilm of the urinary tract using a severely complicated bladder model (biofilm model of the urinary tract)--experimental study using an automatic simulator of urinary antimicrobial agent concentration, and clinical study]
    M Nishimura
    Department of Urology, School of Medicine, Sapporo Medical University
    Kansenshogaku Zasshi 68:386-98. 1994
    ..Using this model, we investigated clarithromycin (CAM), which has been reported to have anti-biofilm action, at concentrations close to its urinary levels at the time of ..
  65. ncbi [Suppressive effect of clarithromycin on the production of verotoxin by E. coli O157]
    K Nakata
    Laboratory of Culture Collection, University of Tokyo
    Kansenshogaku Zasshi 71:437-42. 1997
    Effects of low concentration of clarithromycin (CAM) on the production of Verotoxin (VT) by Escherichia coli O157 was investigated in vitro. The production of VT1 was suppressed up to 10 hours when bacteria was incubated with 0...
  66. ncbi [A mechanism of clarithromycin resistance in Helicobacter pylori]
    T Saika
    Chemotherapy Division, Mitsubishi Kagaku Bio Clinical Laboratories
    Kansenshogaku Zasshi 72:918-23. 1998
    The aim of this study was to elucidate the mechanism of clarithromycin (CAM) resistance in laboratory strains and clinical isolates of Helicobacter pylori. The CAM resistance in laboratory strains was induced in vitro by CAM exposure...
  67. ncbi N-cadherin and integrins: two receptor systems that mediate neuronal process outgrowth on astrocyte surfaces
    K J Tomaselli
    Department of Physiology, University of California, San Francisco 94143-0724
    Neuron 1:33-43. 1988
    ..N-CAM appeared not to be required for neurite outgrowth by either E8 or E14 neurons...
  68. ncbi Sequence determinants of modified cobra venom neurotoxin which induce immune resistance to experimental allergic encephalomyelitis: molecular mechanisms for immunologic action
    C L Hinman
    Department of Medicinal and Biological Chemistry, University of Toledo, Ohio 43606, USA
    Immunopharmacol Immunotoxicol 21:483-506. 1999
    A nontoxic, iodoacetamide-modified cobratoxin derivative (CAM-NTX) induced resistance to experimental allergic encephalomyelitis (EAE) in guinea pigs...
  69. ncbi [Long-term chemotherapy using erythromycin (EM) for chronic lower airway infection: effectiveness of clarithromycin in EM ineffective cases--the fourth report]
    K Mikasa
    Second Department of Internal Medicine, Nara Medical University
    Kansenshogaku Zasshi 66:1097-104. 1992
    ..In the present study was administered Clarithromycin (CAM) to such cases and found that CAM was effective in alleviating symptoms in some of them...
  70. ncbi Subepithelial basement membrane deposition and intermediate filament expression in choroid plexus neoplasms and ependymomas
    P N Furness
    Department of Histopathology, University Hospital, Nottingham, UK
    Histopathology 16:251-5. 1990
    ..In contrast, GFAP was present in all the types of tumour examined. Cytokeratin (as detected by CAM 5.2) was present in all the choroid plexus lesions and also in the ependymomas arising in the spinal canal...
  71. ncbi N-CAM, 43K-rapsyn, and S-laminin mRNAs are concentrated at synaptic sites in muscle fibers
    L M Moscoso
    Department of Anatomy, Washington University School of Medicine, St. Louis, Missouri 63110, USA
    Mol Cell Neurosci 6:80-9. 1995
    ..We found preferential synaptic accumulation of mRNAs for a membrane-associated cell adhesion molecule (N-CAM) and for an acetylcholine receptor-associated cytoskeletal protein (43K-rapsyn)...
  72. pmc Structure of a new nervous system glycoprotein, Nr-CAM, and its relationship to subgroups of neural cell adhesion molecules
    M Grumet
    Rockefeller University, New York, New York 10021
    J Cell Biol 113:1399-412. 1991
    ..revealed that this protein is very similar in structure to the chicken neuron-glia cell adhesion molecule, Ng-CAM, and to mouse L1...
  73. pmc The neuronal chondroitin sulfate proteoglycan neurocan binds to the neural cell adhesion molecules Ng-CAM/L1/NILE and N-CAM, and inhibits neuronal adhesion and neurite outgrowth
    D R Friedlander
    Department of Pharmacology, New York University Medical Center, New York 10016
    J Cell Biol 125:669-80. 1994
    We have previously shown that aggregation of microbeads coated with N-CAM and Ng-CAM is inhibited by incubation with soluble neurocan, a chondroitin sulfate proteoglycan of brain, suggesting that neurocan binds to these cell adhesion ..
  74. ncbi CR 2945: a novel CCKB receptor antagonist with anxiolytic-like activity
    L Revel
    Rotta Research Laboratorium SpA, Monza, Italy
    Behav Pharmacol 9:183-94. 1998
    ..acid derivative member of a novel family of non-peptide CCKB receptor antagonists, have been compared with those of CAM-1028, an analogue of the CCKB receptor antagonist CI-988, L-365,260 a benzodiazepine derivative CCKB antagonist, CR ..
  75. ncbi A review of the use of CAM therapy and the sources of accurate and reliable information
    Mary McHughes
    Department of Pharmacotherapy, College of Pharmacy, University of Utah, 30 South 2000 East Rm 258, Salt Lake City, UT 84112 5820, USA
    J Manag Care Pharm 11:695-703. 2005
    ..IOM) of the National Academies to become more involved in evaluating complementary and alternative medicine (CAM) and to suggest resources pharmacists can access to be better prepared to advise their patients about these ..
  76. ncbi [Sensitivity of Helicobacter pylori to amoxicillin and clarythromycin with special reference to eradication therapy]
    H Tsuneoka
    Department of Clinical Laboratory, Yamaguchi-ken Kouseiren Nagato General Hospital
    Kansenshogaku Zasshi 72:335-41. 1998
    ..ulcer before and after eradication therapy, and studied their sensitivity to amoxicillin (AMPC) and clarythromycin (CAM). Of 85 strains of H. pylori isolated before therapy, MIC90 was 0...
  77. pmc Brain tissue energy dependence of CaM kinase IV cascade activation during hypoxia in the cerebral cortex of newborn piglets
    Maria Delivoria-Papadopoulos
    Department of Pediatrics, Drexel University College of Medicine and St Christopher s, Hospital for Children, Philadelphia, PA 19102, USA
    Neurosci Lett 491:113-7. 2011
    The present study aims to investigate the dependence of CaM kinase IV cascade activation during hypoxia and tests the hypothesis that hypoxia-induced tyrosine phosphorylation of CaM and CaM kinase IV, activation of CaM kinase IV and ..
  78. ncbi Serum-soluble E-cadherin fragments in lung cancer
    M Cioffi
    Istituto di Patologia Generale e Oncologia, , Naples, Italy
    Tumori 85:32-4. 1999
    AIMS AND BACKGROUND: E-cadherin, also known as uvomorulin or cell-CAM 120/80, is one of the subclasses of cadherins, CA(2+)-dependent cell adhesion molecules...
  79. ncbi Effect of neuronal nitric oxide synthase inhibition on CA2+/calmodulin kinase kinase and CA2+/calmodulin kinase IV activity during hypoxia in cortical nuclei of newborn piglets
    A B Zubrow
    Department of Pediatrics, Drexel University College of Medicine and St Christopher s Hospital for Children, Front Street at Erie Avenue, Philadelphia, PA 19134, USA
    Neuroscience 125:937-45. 2004
    The present study tests the hypothesis that cerebral tissue hypoxia results in increased Ca(2+)/calmodulin (CaM) kinase kinase activity and that the administration of nitric oxide synthase inhibitors (N-nitro-l-arginine [NNLA], or 7-..
  80. ncbi Calcium/calmodulin-dependent protein kinase IIalpha mediates activation of mitogen-activated protein kinase and cytosolic phospholipase A2 in norepinephrine-induced arachidonic acid release in rabbit aortic smooth muscle cells
    M M Muthalif
    Department of Pharmacology, College of Medicine, The University of Tennessee Center for Health Sciences, Memphis, Tennessee 38163, USA
    J Biol Chem 271:30149-57. 1996
    We have investigated the contribution of Ca2+/calmodulin-dependent protein kinase II (CaM kinase II) and mitogen-activated protein kinase (MAP kinase) in norepinephrine (NE)-induced arachidonic acid (AA) release in rabbit aortic vascular ..
  81. ncbi [A study to clarify the mechanism of the usefulness of the macrolides--the influence of clarithromycin to biofilm with P. aeruginosa]
    H Takeda
    First Department of Internal Medicine, School of Medicine, Kyorin University
    Kansenshogaku Zasshi 66:1454-61. 1992
    Clarithromycin (CAM) was administered long-term to patients with diffuse panbronchiolitis (DPB) to clarify the mechanism of the usefulness of the macrolides (MLs). 1...
  82. ncbi Characterization of molecular aggregates of alpha 1 beta 1-integrin and other rat liver membrane proteins by combination of size-exclusion chromatography and chemical cross-linking
    K Loster
    Institut fur Molekularbiologie und Biochemie, Freie Universitat Berlin, Dahlem, Germany
    J Chromatogr A 711:187-99. 1995
    ..characterized rat liver membrane proteins, alpha 1 beta 1-integrin, dipeptidyl aminopeptidase IV (DPP IV) and cell-CAM 105 (CAM = cell adhesion molecule), in aggregates could be demonstrated when investigated by size-exclusion ..
  83. ncbi Phosphoenolpyruvate carboxylase genes in C3, crassulacean acid metabolism (CAM) and C3/CAM intermediate species of the genus Clusia: rapid reversible C3/CAM switches are based on the C3 housekeeping gene
    Anja Vaasen
    Physiological Ecology of Plants, Botanical Institute, University of Tubingen, Tubingen, Germany
    Plant Cell Environ 29:2113-23. 2006
    The genus Clusia includes species that exhibit either the C3 or crassulacean acid metabolism (CAM) mode of photosynthesis, or those that are able to switch between both modes according to water availability...
  84. doi Expression of calmodulin genes in wild type and calmodulin mutants of Arabidopsis thaliana under heat stress
    Nisreen A Al-Quraan
    Department of Biological Sciences, Auburn University, Auburn, AL 36849, USA
    Plant Physiol Biochem 48:697-702. 2010
    Calmodulin (CaM), a calcium-regulated protein, regulates the activity of a number of key enzymes and plays important roles in cellular responses to environmental changes...
  85. ncbi Comparative effects of vinpocetine and 8-Br-cyclic GMP on the contraction and 45Ca-fluxes in the rabbit aorta
    P J Chiu
    Department of Pharmacology, Schering-Plough Corporation, Bloomfield, NJ 07003
    Am J Hypertens 1:262-8. 1988
    Vinpocetine is a highly specific inhibitor of calmodulin-dependent phosphodiesterase (CaM-PDE) with an IC50 of 19 microM and produces a significant accumulation of cyclic GMP but not cyclic AMP in rabbit aorta...
  86. ncbi Calmodulin-mediated reversible immobilization of enzymes
    Sylvia Daunert
    Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA
    Colloids Surf B Biointerfaces 58:20-7. 2007
    This work demonstrates the use of the protein calmodulin, CaM, as an affinity tag for the reversible immobilization of enzymes on surfaces...
  87. ncbi [Use of complementary and alternative medicine among the patients in primary health care]
    Tomislav Cizmesija
    National Railroad Health Center, University of Zagreb, Zagreb, Croatia
    Acta Med Croatica 62:15-22. 2008
    Use of complementary and alternative medicine (CAM) is widespread in western countries despite its unconfirmed effectiveness. The aim of the study was to show the use of CAM by patients in primary health care.
  88. ncbi [Role and mechanism of nuclear factor kappa B in angiogenesis of human ovarian carcinoma]
    Li Hua Yang
    Department of Obstetric and Gynecology, Second Affiliated Hospital, Kunming Medical College, Kunming, Yunnan, 650101, PR China
    Ai Zheng 23:531-4. 2004
    ..The objective of this paper was to investigate the role and the mechanism of NF kappa B in HOC angiogenesis in chick chorioallantcic membrane (CAM).
  89. ncbi Calcium occupancy of N-terminal sites within calmodulin induces inhibition of the ryanodine receptor calcium release channel
    Curt B Boschek
    Cell Biology and Biochemistry Group, Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352, USA
    Biochemistry 46:10621-8. 2007
    Calmodulin (CaM) regulates calcium release from intracellular stores in skeletal muscle through its association with the ryanodine receptor (RyR1) calcium release channel, where CaM association enhances channel opening at resting calcium ..
  90. doi Predicting clinical efficacy of photoangiolytic and cutting/ablating lasers using the chick chorioallantoic membrane model: implications for endoscopic voice surgery
    James A Burns
    Department of Surgery, Harvard Medical School, Center for Laryngeal Surgery and Voice Rehabilitation, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Laryngoscope 118:1109-24. 2008
    ..The chick chorioallantoic membrane (CAM) simulates the microvasculature of the human vocal fold and is, therefore, useful for testing effects of laser ..
  91. ncbi Evidence for calcineurin-mediated regulation of SERCA 2a activity in human myocardium
    Götz Münch
    Laboratory of Muscle Research and Molecular Cardiology, Klinik III fur Innere Medizin, University of Cologne, Germany
    J Mol Cell Cardiol 34:321-34. 2002
    ..SERCA 2a activity is regulated by the Ca(2+)/calmodulin-dependent protein kinase (CaM-kinase) but alterations of the CaM-kinase pathway regarding SERCA 2a in heart failure are unresolved...
  92. ncbi [Inhibitory effect of macrolide antibiotics on biofilm formation by Pseudomonas aeruginosa]
    K Kondoh
    Department of Otorhinolaryngology, Nagoya City University Medical School
    Nihon Jibiinkoka Gakkai Kaiho 101:25-36. 1998
    ..a Teflon sheet in minimal medium containing various concentrations of the macrolide antibiotics clarithromycin (CAM), erythromycin (EM) and midecamycin (MDM), at 37 degrees C for 7 days...
  93. ncbi [A child with iritis due to Chlamydia pneumoniae infection]
    S Yamada
    Department of Pediatrics, Kurume University School of Medicine
    Kansenshogaku Zasshi 68:1543-7. 1994
    ..The symptoms subsided with administration of clarithromycin (CAM: 300 mg/day) for 2 weeks. Because of the simultaneous alleviation of iritis, C...
  94. ncbi A device for improved reduction of tibial fractures treated with external fixation
    C I Moorcroft
    Bionics Laboratory, North Staffordshire Hospital, Stoke on Trent, UK
    Proc Inst Mech Eng H 214:449-57. 2000
    ..In each case the fixator has been applied in alignment with the bone, improving dynamization and reducing the likelihood of malunion due to fixator cam slippage.
  95. ncbi Pancreatic endocrine tumor with signet ring cell features: a case report with novel ultrastructural observations
    M B Stokes
    Department of Pathology, New York University Medical Center, New York 10016, USA
    Ultrastruct Pathol 22:147-52. 1998
    ..by numerous mucin-negative, signet ring cells, which were argyrophilic and immunoreactive for cytokeratin (CAM 5.2), chromogranin, synaptophysin, neuron specific enolase, and gastrin...
  96. ncbi Cell adhesion molecules (CAMs) in adrenal medulla in situ and in vitro: enhancement of chromaffin cell L1/Ng-CAM expression by NGF
    M Poltorak
    Preclinical Neurosciences Section, NIMH Neuroscience Center at St Elizabeths, Washington, D C 20032
    Exp Neurol 110:52-72. 1990
    We have studied the expression of the cell adhesion molecules (CAMs) L1/Ng-CAM, N-CAM, J1/tenascin, and myelin-associated glycoprotein and their common carbohydrate L2/HNK-1 epitope in normal rat adrenal gland sections as well as in ..
  97. ncbi Phosphorylation of calmodulin by Ca2+/calmodulin-dependent protein kinase IV
    Atsuhiko Ishida
    Department of Biochemistry, Asahikawa Medical College, Asahikawa, Japan
    Arch Biochem Biophys 407:72-82. 2002
    Calmodulin-dependent protein kinase IV (CaM-kinase IV) phosphorylated calmodulin (CaM), which is its own activator, in a poly-L-Lys [poly(Lys)]-dependent manner...
  98. ncbi Roles of CaM kinase II and phospholamban in SNP-induced relaxation of murine gastric fundus smooth muscles
    Minkyung Kim
    Dept of Physiology and Cell Biology, Univ of Nevada School of Medicine, Anderson Bldg MS352, Reno, NV 89557, USA
    Am J Physiol Cell Physiol 291:C337-47. 2006
    ..murine gastric fundus smooth muscles and increases phospholamban (PLB) phosphorylation by Ca2+/calmodulin (CaM)-dependent protein kinase II (CaM kinase II) suggest that PLB phosphorylation by CaM kinase II participates in ..
  99. doi Evolutionary physiology: the extent of C4 and CAM photosynthesis in the genera Anacampseros and Grahamia of the Portulacaceae
    Lonnie J Guralnick
    Division of Natural Science and Mathematics, Western Oregon University, Monmouth, OR 97361, USA
    J Exp Bot 59:1735-42. 2008
    ..is one of the few terrestrial plant families known to have both C(4) and Crassulacean acid metabolism (CAM) species...
  100. ncbi Nr-CAM expression in the developing mouse nervous system: ventral midline structures, specific fiber tracts, and neuropilar regions
    M Lustig
    Department of Pharmacology, New York University Medical Center, New York, New York 10016, USA
    J Comp Neurol 434:13-28. 2001
    Nr-CAM is a member of the L1 subfamily of cell adhesion molecules (CAMs) that belong to the immunoglobulin superfamily...
  101. doi A comparative study on the regulation of C(3) and C (4) carboxylation processes in the constitutive crassulacean acid metabolism (CAM) plant Kalanchoë daigremontiana and the C(3)-CAM intermediate Clusia minor
    A M Borland
    Department of Agricultural and Environmental Science, Ridley Building, The University, NE1 7RU, Newcastle upon Tyne, UK
    Planta 201:368-78. 1997
    A comparison of carbon metabolism in the constitutive crassulacean acid metabolism (CAM) plant Kalanchoë daigremontiana Hamet et Perr. and the C(3)-CAM intermediate Clusia minor L...

Research Grants80

  1. Oregon CAM Course
    Edward Keenan; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): The proposed Oregon Complementary and Alternative Medicine (CAM) COURSE is a collaborative project between key educators from Oregon Health & Science University (OHSU), Oregon College of Oriental ..
  2. Connective Tissue Mechanotransduction
    Helene M Langevin; Fiscal Year: 2012
    An important goal of physical therapy, sports medicine and many complementary and alternative (CAM) therapies is the prevention of injuries through promotion and maintenance of optimal musculoskeletal function...
  3. Use of Complementary and Alternative Medicine in Patient Management of Diabetes
    Robin R Whitebird; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): In the past decade, complementary and alternative medicine (CAM) has been widely used by patients to help manage a variety of health problems...
  4. Computer-based Patient Provider Communication about CAM Use
    WILLIAM Z TAN; Fiscal Year: 2011
    ..limited English proficiency (LEP) to input information about their use of complementary and alternative medicine (CAM) in their own language so that the data can be relayed to healthcare providers in English...
  5. Isoform specific effects of the autoinhibitory element and the C-terminus of nitr
    JOHN SALERNO; Fiscal Year: 2009
    ..The most important of several inputs is calcium/calmodulin (Ca+2/CaM), but NO synthesis is also influenced by phosphorylation and protein-protein interactions...
  6. Jessica Casciano; Fiscal Year: 2014
    ..has been shown to play a critical role in many aspects of cancer development;the Ca2+-binding protein calmodulin (CaM) is thought to be a major contributor to cancer development and is required for cell proliferation...
  7. Paco S Herson; Fiscal Year: 2016
    ..Stimulated activity is induced by Ca2+/CaM to CaMKII, and prolonged autonomous (Ca2+-independent) activity is induced by autophosphorylation of residue T286 ..
  8. Madeline A Shea; Fiscal Year: 2015
    ..Most members of the NaV family of channels respond to calcium via regulation by calmodulin (CaM), an essential eukaryotic calcium sensor that is comprised of two highly homologous domains (N and C) connected by ..
  9. RAZVAN LIVIU CORNEA; Fiscal Year: 2016
    ..6-CaM conformational changes induced by physiological RyR modulation using novel optical probes...
  10. Functional Consequences of FHC-linked RLC Mutations.
    Danuta Szczesna-Cordary; Fiscal Year: 2012
    ..RLC Ca2+-Mg2+ binding site during muscle contraction? SPECIFIC AIM 2: Is RLC phosphorylation by Ca2+-calmodulin (CaM) activated myosin light chain kinase (MLCK) affected by FHC-linked RLC mutations? Can MLCK phosphorylation rescue a ..
  11. Calcium Sensing Proteins in Depression
    Yogesh Dwivedi; Fiscal Year: 2013
    ..varied effects of Ca2+ are mediated through Ca2+ sensing proteins;one highly characterized member is calmodulin (CaM). Recently, two different subfamilies of Ca2+ sensing proteins have been identified, i.e...
  12. David D Thomas; Fiscal Year: 2016
    ..The present proposal focuses on the effect of methionine oxidation in two key muscle proteins - calmodulin (CaM), in its role as regulator of the calcium release channel (ryanodine receptor, RyR) and myosin, in its role as ..
  13. AKAP Regulation of Neuronal L-type Calcium Channel Signaling to the Nucleus
    MARK L DELL'ACQUA; Fiscal Year: 2013
    ..a modified leucine zipper (LZ) motif and anchors the cAMP-dependent protein kinase (PKA) and Ca2+-calmodulin (CaM)-activated protein phosphatase-2B (calcineurin;CaN), as an essential regulator of neuronal LTCC currents and NFAT ..
  14. Calcium regulation of flagellar motility
    Elizabeth F Smith; Fiscal Year: 2012
    ..The discovery that calmodulin (CaM) is a key calcium sensor and that highly conserved CaM-binding proteins are localized to axonemal structures known ..
  15. CaM Kinase Cascades in Endocrine Cells
    Anthony R Means; Fiscal Year: 2010
    ..The primary Ca2+ receptor is calmodulin (CaM) and Ca2+/CaM activates several CaM kinases in endocrine cells...
  16. Richard Aldrich; Fiscal Year: 2015
    ..demonstrates that, by isolating the binding signals from a small subset of ligated configurations of the SK/CaM complex, conditional binding measurements are both necessary and sufficient for estimating microscopic, site-..
  17. Calmodulin Regulates Fas-Mediated Apoptosis: A Target for Cancer Therapy
    Jay M McDonald; Fiscal Year: 2013
    ..We have found that antagonists of calmodulin (CaM) induce apoptosis of cholangiocarcinoma cells via a mechanism related to the Fas-mediated apoptosis pathways and ..
  18. Transcriptional Regulation by the HTLV-1 Tax Protein
    Jennifer K Nyborg; Fiscal Year: 2013
    ..We propose to biochemically dissect the interconnection between Tax, pCREB, the CaM-kinases and cyclin D1, and investigate the molecular mechanisms of Tax deregulation of these critical cellular ..
  19. Isoform-Specific Regulation of Skeletal Muscle Calcium Channel by Calmodulin
    Naohiro Yamaguchi; Fiscal Year: 2013
    ..underlying regulation of the skeletal muscle Ca2+ release channel (type 1 ryanodine receptor, RyR1) by calmodulin (CaM), a cytoplasmic Ca2+ binding protein...
  20. Role of neuroligins in long-term plasticity at excitatory and inhibitory synapses
    Holly Sue Engelman; Fiscal Year: 2010
    ..the activated form of Protein Kinase B/Akt, which mediates the effect of insulin, or calcium/calmodulin to activate CaM Kinase II, the effector of the NMDA response, while monitoring elPSCs in WT and NL2-KO slices...
  21. William A Catterall; Fiscal Year: 2016
    ..behavioral levels using a recently developed knock-in mouse line in which the IQ-like motif that is required for CaM-dependent facilitation of Cav2.1 channels has been mutated to prevent facilitation of channel activity (Cav2...
  22. JOHN ANTHONY PUTKEY; Fiscal Year: 2016
    ..of intracellular Ca2+ control the activity of the ubiquitous and essential signaling protein, calmodulin (CaM)...
  23. PAUL ROBERT EVANS; Fiscal Year: 2015
    ..New data shows that RGS14 interacts with the key intracellular calcium sensor calmodulin (CaM) in a calcium-dependent manner...
  24. Role of Neurogranin in Hippocampal Synaptic Plasticity
    Nashaat Z Gerges; Fiscal Year: 2013
    ..Thus, through its regulation of CaM availability, neurogranin may play an important role in synaptic plasticity...
  25. D1 Dopamine Receptor Signaling and Cocaine Reinstatement
    ROBERT CHRISTOPHER PIERCE; Fiscal Year: 2012
    ..between accumbal shell dopamine and glutamate that are mediated by calcium/calmodulin-dependent protein kinase II (CaM-KII). Stimulation of D1-like (i.e...
  26. Andy Hudmon; Fiscal Year: 2015
    ..Calcium-calmodulin (CaM)-dependent protein kinase II (CaMKII) is a multifunctional Ser/Thr protein kinase that is essential for normal ..
  27. GAP JUNCTIONS AND IONIC CURRENTS IN DEVELOPING HEART
    Jenny J Yang; Fiscal Year: 2013
    ..a new final aim of this proposal, we demonstrate the functional significance of recently predicted Cx43 calmodulin (CaM) binding domain to the calcium regulation of myocardial gap junctions formed predominantly by Cx43 and Cx40...
  28. Developing Ca2+/CaM Kinase II Inhibitors to Treat Arrhythmias in Heart Failure
    Howard Schulman; Fiscal Year: 2012
    ....
  29. Structural rearrangements in SK channels during CaM-mediated gating
    RIINA MAIE LUIK; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Calmodulin (CaM) acts as the primary cytosolic [Ca2+] sensor for Ca2+ signaling processes as diverse as secretion, motility, transcription, and proliferation...
  30. Pancreatic beta-cell CAMKII signaling under physiological and diabetic conditions
    DAVID AARON JACOBSON; Fiscal Year: 2013
    ..The calcium/calmodulin-dependent kinase II (CaM kinase II) serves as a signaling intermediate between glucose induced calcium entry and insulin secretion...
  31. Christopher N Johnson; Fiscal Year: 2015
    ..5. This process is known to involve the intracellular calcium sensing protein calmodulin (CaM), specific elements of the channel located near the C terminus, and the linker region between domains 3 and 4 (D3D4 ..
  32. JAMIL SUBHI SAAD; Fiscal Year: 2014
    ..HIV-1 Gag was shown to interact and co-localize with calmodulin (CaM) in the cytoplasm...
  33. Donald M Bers; Fiscal Year: 2015
    ..Ubiquitous Ca regulatory systems, Ca-calmodulin (CaM) dependent protein kinase II (CaMKll), calcineurin and inositol (1,4,5)P3 receptors (InsP3R) in myocytes have been ..
  34. State Dependent Affinity of Calmodulin for SK2
    DAVID BRENT HALLING; Fiscal Year: 2012
    ..The rapid activation of SK2 requires a ubiquitous Ca2+ sensing protein, calmodulin (CaM)...
  35. Regulation of Calcium Channel Function by the Rem GTPase
    Jonathan Satin; Fiscal Year: 2013
    ..Two of the most physiologically relevant controls of I(Ca) are PKA-modulation and calmodulin (CaM)-modulation. Our most recent studies suggest that Rem modulates I(Ca) responses to each of these signaling pathways...
  36. Daniel R Storm; Fiscal Year: 2015
    ..Calmodulin (CaM)-stimulated adenylyl cyclases, and Erk/MAP kinase (MAPK) plays a major role in calcium activation of CRE-mediated ..
  37. TRE17 links actin remodeling & vesicle trafficking
    Margaret Chou; Fiscal Year: 2009
    ..Our preliminary data further identifies calcium/calmodulin (Ca2+/CaM) as an allosteric regulator of TRE17...
  38. Geoffrey S Pitt; Fiscal Year: 2016
    ..2 current;and (c) whether calmodulin (CaM) associated with the C-terminus of [unreadable]1C regulates channel biosynthesis in cardiomyocytes in a Ca2+-..
  39. Mechanisms of Ca2+ and voltage-dependent inactivation Ca channels
    MANU B JOHNY; Fiscal Year: 2013
    ..overall goal of this proposal is to identify the intermediate events that follow depolarization or Ca binding to CaM and to elucidate the final conformations of CDI and VDI through 3 aims: (1) Does Calmodulin(CalVI) induce CDI by ..
  40. The Effect Of Deafness Associated Mutations on MyosinVIIA Function
    Eva Forgacs; Fiscal Year: 2010
    ..In the single molecule motility measurements, fluorescently labeled CaM light chain will be added to the myosin VIIA and the movement of the molecule will be measured by Total Internal ..
  41. Mechanism and functional role of AKAP79/150 in M current control
    Mark S Shapiro; Fiscal Year: 2012
    ..One such AKAP, AKAP79/150 interacts with protein kinase A, protein kinase C (PKC), calmodulin (CaM), calcineurin (CaN), ion channels such as M-type (KCNQ, Kv7) K+ channels, L-type Ca2+ channels and G protein-..
  42. Ryanodine receptor in cardiac hypertrophy and heart failure
    GERHARD W MEISSNER; Fiscal Year: 2013
    ..The RyR2 ion channel is composed of four RyR2 560 kDa subunits that bind calmodulin (CaM), and four small 12.6 kDa FK506 binding proteins...
  43. Martin F Schneider; Fiscal Year: 2016
    ..activation are poorly understood, and the roles of various modulatory molecules, including S100A1 and calmodulin (CaM) are not clear...
  44. James T Stull; Fiscal Year: 2016
    ..These movements respond to increased cytosolic Ca2+ concentrations ([Ca2+]i) and activation of Ca2+/calmodulin (CaM)-dependent myosin light chain kinase (MLCK)...
  45. DAPK1 regulation of NMDA receptors in ischemic neuronal death
    NICOLAS GUILLERMO BAZAN; Fiscal Year: 2012
    ..DAPK1 is one member of Ca2+/calmodulin (CaM)-dependent serine/threonine kinase family and functions as a critical mediator of cell death...
  46. Regulation of GPER-mediated Signaling in the Vasculature by Calmodulin
    Kim Tran; Fiscal Year: 2012
    ..Calmodulin (CaM) is involved in virtually all aspects of cell functions but is not expressed sufficiently for all its targets...
  47. ROLE OF CASPASE-2 IN OSTEOCOLAST APOPTOSIS AGE-EePENDENT OSTEOPOROSIS
    Brian A Herman; Fiscal Year: 2011
    ..Calmodulin (CaM) dependent kinase II (CaMK II) can phosphorylate procaspase-2 and prevent its activation...
  48. Mark S Shapiro; Fiscal Year: 2014
    ..We hypothesize PIP2 and CaM to act on overlapping domains on the channels, providing for allosteric "cross-talk...
  49. COURTNEY BLAKE NICHOLS; Fiscal Year: 2014
    ..During the increase in [Ca2+]i Ca2+ bound calmodulin (Ca-CaM) binds to and activates CaMKII and CaN;thereby phosphorylating or dephosphorylating several important Ca2+ handling ..
  50. Richard S Lewis; Fiscal Year: 2016
    ..Recent findings have revealed required roles for STIM1, calmodulin (CaM) and the intracellular II-III loop of Orai1 in the CDI mechanism...
  51. Molecular Studies of the Roles and Regulations of the v-ATPase V0 Sector
    Florante A Quiocho; Fiscal Year: 2010
    ..We discovered, through biochemical and structural analysis, that V100 is a target of Ca2+.calmodulin (Ca2+.CaM)...
  52. NEPALLI RAMA KRISHNA; Fiscal Year: 2014
    ..we hypothesize that small molecule compounds that inhibit the interaction of the c-Src-SH2 domain with cellular CaM will also effectively inhibit the signaling pathway through which the pancreatic cancer cells escape apoptosis...
  53. CRCNS: Modeling Activation of CaMKII in Spines
    Terrence J Sejnowski; Fiscal Year: 2013
    ..to build an accurate dynamic model of activation and autophosphorylation of the signaling protein Ca2+/calmodulin (CaM)-dependent protein kinase II (CaMKII) during influx of Ca2+ into the postsynaptic spine through NMDA receptors...
  54. Roger J Colbran; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): The activity and subcellular localization of Ca2+/calmodulin(CaM)-dependent protein kinase II (CaMKII) are regulated by Ca2+/CaM binding, autophosphorylation at Thr286 and Thr305/306, and ..
  55. Structural and biochemical characterization of redox reactions within nitric oxid
    SARAH C HOKANSON; Fiscal Year: 2012
    ..Crosstalk between the two domains is regulated by a calmodulin (CaM)-binding interface...
  56. SK2-associated protein kinase CK2: molecular basis and physiological roles
    John P Adelman; Fiscal Year: 2010
    ..Ca2+-activated K+ channels (SK channels) are gated directly by Ca2+ ions, via constitutively associated calmodulin (CaM)...
  57. Transmembrane Regulation of Ectodomain Shedding
    Renhao Li; Fiscal Year: 2012
    ..The best characterized example is the calmodulin (CaM) association with L-selectin to inhibit shedding of L-selectin...
  58. Regulation of 5-HT1A Receptor by Calmodulin
    Sonya D Coaxum; Fiscal Year: 2012
    ..In that regard, previous studies have reported that the 5-HT1A receptor has calmodulin (CaM) binding domains in the third intracellular loop (i3L) of the receptor (2)...
  59. The Role of the Activity-Regulated GTPase Rem2 in Dendrite Development
    AMY ELIZABETH GHIRETTI; Fiscal Year: 2013
    ..Additionally, the ability of Rem2 to mediate dendritic morphology is dependent on Rem2 binding to calmodulin (CaM)...
  60. Marc Jan Gubbels; Fiscal Year: 2014
    ..Two small, Ca2+-binding proteins, calmodulin (CaM;4 EF-hands) and the calcineurin phosphatase (the regulatory [unreadable]-subunit has 4 EF hands), have been ..
  61. Gating of Connexin-Based Gap Junction Channels and Hemichannels
    Feliksas Bukauskas; Fiscal Year: 2013
    ..In Sp. Aims 1 and 3, we will test whether Vj- and pH-dependent gating is associated with a change in calmodulin (CaM) co-localization with GJs and whether CaM influences the interaction between H+ ions and gating elements of slow ..
  62. Subcellular Localization of Cav1.2 by alpha-actinin
    Johannes W Hell; Fiscal Year: 2011
    ..2. We will define residues on Cav1.2 that are critical for a-actinin but not CaM binding and vice versa. We will inhibit the interactions between a-actinin and Cav1...
  63. Geoffrey S Pitt; Fiscal Year: 2016
    ..Among these auxiliary CTD-interacting proteins, the ubiquitous Ca2+ sensor calmodulin (CaM) and fibroblast growth factor homologous factors (FHFs;FGF11-FGF14) are of particular interest: many disease- ..
  64. William N Zagotta; Fiscal Year: 2015
    ..Ca2+/Calmodulin (Ca2+/CaM) and ATP may modulate its activity as well...
  65. CAM Curriculum Project
    Mary Jo Kreitzer; Fiscal Year: 2004
    ..The Center for Spirituality and Healing provides the infrastructure for drawing together CAM practitioners and AHC faculty to engage in collaborative education, research and practice...
  66. CALMODULIN KINASE II AND ION TRANSPORT IN THE KIDNEY
    Rochelle Hanley; Fiscal Year: 1992
    Calcium-calmodulin dependent protein kinase II) (CaM-KII) is a widely distributed enzyme with a broad substrate specificity...
  67. CALMODULIN IN ANDROGEN REGULATION OF PROSTATE CANCER
    Prem Veer Reddy; Fiscal Year: 2003
    ..Progression of cells from G1 into S phase is dependent on events regulated by calcium ion and calmodulin (CaM). Inhibition of CaM at G1/S boundary, prevents cells from entering into S phase...
  68. MD Study of Anthrax Edema Factor:Calmodulin Complexes
    Shuanghong Huo; Fiscal Year: 2003
    ..is to understand the precise conformational and dynamic requirements for both effective binding of calmodulin (CAM) to the anthrax edema factor (EF) and the generation of a fully functional adenylyl cyclase active site...
  69. Switching Kinetics in Calmodulin-IQ Domain Complexes
    Anthony Persechini; Fiscal Year: 2009
    An extensive class of proteins binds the Ca2+-binding protein calmodulin (CaM) through what are termed "IQ domains"...
  70. SINGLE-MOLECULE DYNAMICS OF TARGET BINDING BY CALMODULIN
    CAREY JOHNSON; Fiscal Year: 2003
    ..Verbatim from the Applicant's Abstract) The overall goal of this project is to detect single calmodulin(CaM) molecules as they function. Key questions need to be answered about how CaM recognizes and binds to a target...
  71. CALMODULIN FUNCTION IN THE CELL
    Anthony Persechini; Fiscal Year: 2002
    When it binds Ca2+, calmodulin (CaM) activates an enormous array of different enzymes with critical functions in the cell...
  72. URINALYSIS FOR PATIENT COMPLIANCE TO CAM THERAPY
    Rama Ramanujam; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): URINALYSIS FOR PATIENT COMPLIANCE TO CAM THERAPY: In recent years, with increasing dissatisfaction with modern medicines coupled with a desire for healthy living, there has been a ..
  73. Morgan State University-Public Health Program-CAM Research Training Program (Inst
    YVONNE LAFAYETTE BRONNER; Fiscal Year: 2010
    ..recruit and train Post and Pre doctoral fellows and short-term trainees in research related to the epidemiology of CAM practices (especially among minorities), botanical content standardization, safety and efficacy of using botanicals/..
  74. Academic Career Development in CAM Research and Education
    ROBERT SAPER; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Despite the popularity of complementary and alternative medicine (CAM), little is known about the feasibility and effectiveness of CAM for low income minority populations...
  75. Mind-Body E-Portal: A Practice-to-Research Platform for Consumer-Driven Wellness
    Joel B Bennett; Fiscal Year: 2010
    ..holistic wellness and a practice-based research community for the study of complementary and alternative medicine (CAM)...
  76. Comparison of the Effectiveness of CAM Therapies in Pediatric Patients Undergoing
    AMBIKA contact MATHUR; Fiscal Year: 2010
    ..Non-invasive complementary and alternative medicine (CAM) therapies, including passive music therapy, active music therapy, and distraction procedures have been reported in ..
  77. Complementary & Alternative Care Behavior in HIV+ Latinos in the US-Mexico
    MARIA LUISA ZUNIGA DE NUNCIO; Fiscal Year: 2010
    ..participatory research study is to identify the nature and extent of complementary and alternative medicine (CAM) use among HIV-positive Latinos in the United States (US) - Mexico border region...
  78. NR/CAM AND FORMATION OF NODE OF RANVIER
    Martin Grumet; Fiscal Year: 2002
    ..Recent studies demonstrated that a subset of cell adhesion molecules (CAMs) in the Ig Superfamily (i.e., Nr-CAM and neurofascin) are specifically localized to the node at early stages of its formation...