KLLN

Summary

Gene Symbol: KLLN
Description: killin, p53-regulated DNA replication inhibitor
Alias: CWS4, KILLIN, killin
Species: human

Top Publications

  1. pmc Germline epigenetic regulation of KILLIN in Cowden and Cowden-like syndrome
    Kristi L Bennett
    Genomic Medicine Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
    JAMA 304:2724-31. 2010
  2. doi Activation of AR sensitizes breast carcinomas to NVP-BEZ235's therapeutic effect mediated by PTEN and KLLN upregulation
    Yu Wang
    Corresponding Author Charis Eng, Cleveland Clinic, 9500 Euclid Avenue, NE 50, Cleveland, OH 44195
    Mol Cancer Ther 13:517-27. 2014
  3. ncbi Upregulated microRNA-224 promotes ovarian cancer cell proliferation by targeting KLLN
    Ke Hu
    Department of Life Sciences, Bengbu Medical College, Bengbu, People s Republic of China
    In Vitro Cell Dev Biol Anim . 2016
  4. pmc XTEN as Biological Alternative to PEGylation Allows Complete Expression of a Protease-Activatable Killin-Based Cytostatic
    Akvile Haeckel
    Department of Radiology, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS ONE 11:e0157193. 2016
  5. pmc Role of DNA methylation in renal cell carcinoma
    Niraj Shenoy
    Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10467, USA
    J Hematol Oncol 8:88. 2015
  6. pmc Cell cycle specific distribution of killin: evidence for negative regulation of both DNA and RNA synthesis
    Man Qiao
    a Center for Growth, Metabolism and Aging Department of Biochemistry and Molecular Biology School of Life Sciences Sichuan University Chengdu, China
    Cell Cycle 14:1823-9. 2015
  7. pmc KLLN epigenotype-phenotype associations in Cowden syndrome
    Emily A Nizialek
    Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH, USA
    Eur J Hum Genet 23:1538-43. 2015
  8. pmc Germline PTEN, SDHB-D, and KLLN alterations in endometrial cancer patients with Cowden and Cowden-like syndromes: an international, multicenter, prospective study
    Haider Mahdi
    Section of Gynecologic Oncology ObGyn and Women s Health Institute, Cleveland Clinic, Cleveland, Ohio
    Cancer 121:688-96. 2015
  9. doi Nuclear KLLN expression associates with improved relapse-free survival for prostate carcinoma
    Yu Wang
    Genomic Medicine InstituteDepartment of Anatomic PathologyCleveland Clinic, Cleveland, Ohio 44195, USADepartment of UrologyStanford University School of Medicine, Stanford, California 94305, USATaussig Cancer InstituteStanley Shalom Zielony Institute for Nursing ExcellenceCleveland Clinic, Cleveland, Ohio 44195, USADepartment of Genetics and Genome SciencesCASE Comprehensive Cancer CenterCase Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Endocr Relat Cancer 21:579-86. 2014
  10. doi pKILLIN: a versatile positive-selection cloning vector based on the toxicity of Killin in Escherichia coli
    Zelong Ma
    Center for Growth, Metabolism and Aging, School of Life Sciences, Sichuan University, Chengdu 610064, China
    Gene 544:228-35. 2014

Research Grants

  1. EMILY ALISON NIZIALEK; Fiscal Year: 2015
  2. CHRISTOPHER EDWARD MASON; Fiscal Year: 2014
  3. GARY JAY BRENNER; Fiscal Year: 2016
  4. Genetic Etiologies of Esophageal Barrett's and Cancer
    Charis Eng; Fiscal Year: 2003
  5. RET RECEPTOR POLYMORPHISMS & HIRSCHSPRUNG DISEASE
    Charis Eng; Fiscal Year: 2004

Scientific Experts

  • Charis Eng
  • Niraj Shenoy
  • Yong Jig Cho
  • Yu Wang
  • Emily A Nizialek
  • EMILY ALISON NIZIALEK
  • CHRISTOPHER EDWARD MASON
  • GARY JAY BRENNER
  • Kristi L Bennett
  • Jessica L Mester
  • Xin He
  • Joanne Ngeow
  • Akvile Haeckel
  • Ke Hu
  • Man Qiao
  • Haider Mahdi
  • Dan Luo
  • Peng Liang
  • Zelong Ma
  • Donna M Peehl
  • Qi Yu
  • Ella R Thompson
  • Jessica Mester
  • Angela Ariza de Schellenberger
  • Franziska Appler
  • Eyk Schellenberger
  • Meng Liang
  • Guangping Luo
  • Haiyan Feng
  • Dominic J Smiraglia
  • Vineet K Dhiman
  • Chad Michener
  • Yi Kuang
  • Yuquan Wei
  • Todd Romigh
  • Yunxiao Wang
  • AnLiang Huang
  • Andres Roma
  • Jessica Altemus
  • Rosalie Nolley
  • Fadi Abdul-Karim
  • Yang Xu
  • Charissa Peterson
  • Erinn Downes-Kelly
  • Deepa Radhakrishnan
  • Kylie L Gorringe
  • Diana M Eccles
  • Gillian Mitchell
  • Ian G Campbell
  • David Y H Choong
  • Mira Milas
  • Lisa A Rybicki
  • Ming Zhou
  • Shireen Ganapathi
  • Ram Ganapathi
  • Hartmut P H Neumann
  • Brian Rini
  • Rebecca Campbell
  • Ying Ni

Detail Information

Publications18

  1. pmc Germline epigenetic regulation of KILLIN in Cowden and Cowden-like syndrome
    Kristi L Bennett
    Genomic Medicine Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
    JAMA 304:2724-31. 2010
    ..mechanisms of loss of function such as hypermethylation, which should result in underexpression of PTEN or of KILLIN, a novel tumor suppressor transcribed in the opposite direction, may account for the remainder of Cowden syndrome ..
  2. doi Activation of AR sensitizes breast carcinomas to NVP-BEZ235's therapeutic effect mediated by PTEN and KLLN upregulation
    Yu Wang
    Corresponding Author Charis Eng, Cleveland Clinic, 9500 Euclid Avenue, NE 50, Cleveland, OH 44195
    Mol Cancer Ther 13:517-27. 2014
    ..This beneficial effect was mediated by dihydrotestosterone (DHT)-induced PTEN and KLLN expression. Furthermore, DHT could also reverse NVP-BEZ235-induced side effects such as skin rash and weight loss...
  3. ncbi Upregulated microRNA-224 promotes ovarian cancer cell proliferation by targeting KLLN
    Ke Hu
    Department of Life Sciences, Bengbu Medical College, Bengbu, People s Republic of China
    In Vitro Cell Dev Biol Anim . 2016
    ..Furthermore, microRNA-224 was confirmed to target KLLN in HO8910 and HO8910PM...
  4. pmc XTEN as Biological Alternative to PEGylation Allows Complete Expression of a Protease-Activatable Killin-Based Cytostatic
    Akvile Haeckel
    Department of Radiology, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS ONE 11:e0157193. 2016
    ..coli, is less immunogenic, and is biodegradable. We tested constructs containing a fragment of Killin as cytostatic/cytotoxic element, a cell-penetrating peptide, an MMP-2 cleavage site for specific activation, and ..
  5. pmc Role of DNA methylation in renal cell carcinoma
    Niraj Shenoy
    Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10467, USA
    J Hematol Oncol 8:88. 2015
    ..of the Wnt and TGF-beta pathways, pro-apoptotic genes such as APAF-1 and negative cell-cycle regulators such as KILLIN have been shown to be epigenetically silenced in numerous studies in ccRCC...
  6. pmc Cell cycle specific distribution of killin: evidence for negative regulation of both DNA and RNA synthesis
    Man Qiao
    a Center for Growth, Metabolism and Aging Department of Biochemistry and Molecular Biology School of Life Sciences Sichuan University Chengdu, China
    Cell Cycle 14:1823-9. 2015
    p53 tumor-suppressor gene is a master transcription factor which controls cell cycle progression and apoptosis. killin was discovered as one of the p53 target genes implicated in S-phase control coupled to cell death...
  7. pmc KLLN epigenotype-phenotype associations in Cowden syndrome
    Emily A Nizialek
    Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH, USA
    Eur J Hum Genet 23:1538-43. 2015
    Germline KLLN promoter hypermethylation was recently identified as a potential genetic etiology of the cancer predisposition syndrome, Cowden syndrome (CS), when no causal PTEN gene mutation was found...
  8. pmc Germline PTEN, SDHB-D, and KLLN alterations in endometrial cancer patients with Cowden and Cowden-like syndromes: an international, multicenter, prospective study
    Haider Mahdi
    Section of Gynecologic Oncology ObGyn and Women s Health Institute, Cleveland Clinic, Cleveland, Ohio
    Cancer 121:688-96. 2015
    ..in phosphatase and tensin homolog (PTEN; PTEN_mut+), succinate dehydrogenase B/C/D (SDHB-D; SDHx_var+), and killin (KLLN_Me+) cause CS and Cowden syndrome-like (CSL) phenotypes...
  9. doi Nuclear KLLN expression associates with improved relapse-free survival for prostate carcinoma
    Yu Wang
    Genomic Medicine InstituteDepartment of Anatomic PathologyCleveland Clinic, Cleveland, Ohio 44195, USADepartment of UrologyStanford University School of Medicine, Stanford, California 94305, USATaussig Cancer InstituteStanley Shalom Zielony Institute for Nursing ExcellenceCleveland Clinic, Cleveland, Ohio 44195, USADepartment of Genetics and Genome SciencesCASE Comprehensive Cancer CenterCase Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Endocr Relat Cancer 21:579-86. 2014
    ..Additional prognostic markers are needed to predict the outcome of these patients. KLLN is a transcription factor that regulates the cell cycle and induces apoptosis in cancer cells...
  10. doi pKILLIN: a versatile positive-selection cloning vector based on the toxicity of Killin in Escherichia coli
    Zelong Ma
    Center for Growth, Metabolism and Aging, School of Life Sciences, Sichuan University, Chengdu 610064, China
    Gene 544:228-35. 2014
    ..The essence behind its high cloning efficiency is the extreme toxicity and small size of the toxic domain of killin, a recently discovered p53 target gene...
  11. pmc Germline and somatic KLLN alterations in breast cancer dysregulate G2 arrest
    Emily A Nizialek
    Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Hum Mol Genet 22:2451-61. 2013
    ..b>KLLN, which shares a bidirectional promoter with PTEN, causes cell cycle arrest and apoptosis...
  12. doi Androgen receptor-induced tumor suppressor, KLLN, inhibits breast cancer growth and transcriptionally activates p53/p73-mediated apoptosis in breast carcinomas
    Yu Wang
    Genomic Medicine Institute, Cleveland, OH 44195, USA
    Hum Mol Genet 22:2263-72. 2013
    ..b>KLLN, encoding KLLN protein, is a newly identified gene, which shares a bidirectional promoter with PTEN and is ..
  13. pmc Transcription factor KLLN inhibits tumor growth by AR suppression, induces apoptosis by TP53/TP73 stimulation in prostate carcinomas, and correlates with cellular differentiation
    Yu Wang
    Genomic Medicine Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Clin Endocrinol Metab 98:E586-94. 2013
    b>KLLN is a newly identified gene with unknown function and shares a bidirectional promoter with PTEN.
  14. doi Analysis of KLLN as a high-penetrance breast cancer predisposition gene
    Ella R Thompson
    VBCRC Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett St, East Melbourne, VIC 8006, Australia
    Breast Cancer Res Treat 134:543-7. 2012
    b>KLLN is a p53 target gene with DNA binding function and represents a highly plausible candidate breast cancer predisposition gene...
  15. pmc Incidence and clinical characteristics of thyroid cancer in prospective series of individuals with Cowden and Cowden-like syndrome characterized by germline PTEN, SDH, or KLLN alterations
    Joanne Ngeow
    Genomic Medicine Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    J Clin Endocrinol Metab 96:E2063-71. 2011
    ..Thyroid cancer is believed to be an important component of Cowden syndrome (CS). Germline PTEN and SDHx mutations and KLLN epimutation cause CS and CS-like phenotypes...
  16. pmc Killin is a p53-regulated nuclear inhibitor of DNA synthesis
    Yong Jig Cho
    Department of Cancer Biology, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 105:5396-401. 2008
    ..Here, we report the discovery of a p53 target gene dubbed killin, which lies in close proximity to pten on human chromosome 10 and encodes a 20-kDa nuclear protein...
  17. pmc Germline and somatic DNA methylation and epigenetic regulation of KILLIN in renal cell carcinoma
    Kristi L Bennett
    Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Genes Chromosomes Cancer 50:654-61. 2011
    We recently identified germline methylation of KILLIN, a novel p53-regulated tumor suppressor proximal to PTEN, in >1/3 Cowden or Cowden syndrome-like (CS/CSL) individuals who are PTEN mutation negative...
  18. doi S-phase-coupled apoptosis in tumor suppression
    Yong Jig Cho
    Department of Cancer Biology, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Cell Mol Life Sci 68:1883-96. 2011
    ..This review focuses on accumulating evidence, with the emphasis on recently discovered Killin, that S-phase checkpoint control is crucial for a mammalian cell to make a life and death decision in order to ..

Research Grants5

  1. EMILY ALISON NIZIALEK; Fiscal Year: 2015
    ..Recently, our lab identified germline hypermethylation of the gene KILLIN (KLLN) which is located 5'to PTEN and the two genes share a bidirectional promoter...
  2. CHRISTOPHER EDWARD MASON; Fiscal Year: 2014
    ..we have developed a novel strategy to both control the cell cycle in tumor cells and sensitize them to cytotoxic killin. We have demonstrated, for the first time, that 1) selective inhibition of CDK4/CDK6 leads to early G1 arrest and, ..
  3. GARY JAY BRENNER; Fiscal Year: 2016
    ..It is hypothesize that this bystander killin is mediated by both tumor- and host-specific mechanisms that involve humoral- and cell-mediated pathways...
  4. Genetic Etiologies of Esophageal Barrett's and Cancer
    Charis Eng; Fiscal Year: 2003
    ..This might facilitate molecular diagnostics and early prediction as well as targeted surveillance and prophylaxis. ..
  5. RET RECEPTOR POLYMORPHISMS & HIRSCHSPRUNG DISEASE
    Charis Eng; Fiscal Year: 2004
    ..Finally variants found to be associated with disease status will be tested functionally at the transcript, protein and cell biological level. ..