KLKB1

Summary

Gene Symbol: KLKB1
Description: kallikrein B1
Alias: KLK3, PKK, PKKD, PPK, plasma kallikrein, kallikrein B, plasma (Fletcher factor) 1, kininogenin, plasma prekallikrein
Species: human

Top Publications

  1. ncbi Keratin 9 mutations in the coil 1A region in epidermolytic palmoplantar keratoderma
    S Szalai
    Department of Dermatology, , Budapest, Hungary
    Pediatr Dermatol 16:430-5. 1999
  2. ncbi Fine mapping of the H-kininogen binding site in plasma prekallikrein apple domain 2
    Thomas Renne
    Institute of Clinical Biochemistry and Pathobiochemistry, Julius Maximilians University at Würzburg, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
    Int Immunopharmacol 2:1867-73. 2002
  3. ncbi Distribution of 15 human kallikreins in tissues and biological fluids
    Julie L V Shaw
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    Clin Chem 53:1423-32. 2007
  4. ncbi Identification of putative serum glycoprotein biomarkers for human lung adenocarcinoma by multilectin affinity chromatography and LC-MS/MS
    Sun Hee Heo
    Department of Biochemistry, School of Dentistry, Kyungpook National University, Daegu, Korea
    Proteomics 7:4292-302. 2007
  5. ncbi Kallikrein gene expression in human pituitary tissues
    J A Clements
    Prince Henry s Institute of Medical Research, St Vincent s Hospital, Victoria, Australia
    Clin Endocrinol (Oxf) 44:223-31. 1996
  6. ncbi Mal de Meleda (MDM) caused by mutations in the gene for SLURP-1 in patients from Germany, Turkey, Palestine, and the United Arab Emirates
    Katja Martina Eckl
    Gene Mapping Centre and Department of Molecular Genetics, Max Delbrück Centre Moecular Medicine, Berlin, Germany
    Hum Genet 112:50-6. 2003
  7. ncbi A novel mutation and large size polymorphism affecting the V2 domain of keratin 1 in an African-American family with severe, diffuse palmoplantar keratoderma of the ichthyosis hystrix Curth-Macklin type
    Elizabeth S Richardson
    Department of Dermatology and Cutaneous Biology, The Jefferson Institute of Molecular Medicine, Jefferson Medical College, Philadelphia, Pennsylvania, USA
    J Invest Dermatol 126:79-84. 2006
  8. ncbi Characterization of androgen receptor and nuclear receptor co-regulator expression in human breast cancer cell lines exhibiting differential regulation of kallikreins 2 and 3
    Angeliki Magklara
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    Int J Cancer 100:507-14. 2002
  9. pmc The phosphoinositide kinase PIKfyve/Fab1p regulates terminal lysosome maturation in Caenorhabditis elegans
    Anne Sophie Nicot
    Department of Molecular Pathology, Institut National de la Santé et de la Recherche Médicale U596, Centre National de la Recherche Scientifique Unité Mixte de Recherche 7104, Universite Louis Pasteur de Strasbourg, Illkirch, France
    Mol Biol Cell 17:3062-74. 2006
  10. pmc Circulating prostate tumor cells detected by reverse transcription-PCR in men with localized or castration-refractory prostate cancer: concordance with CellSearch assay and association with bone metastases and with survival
    Pauliina Helo
    Departments of Surgery Urology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Clin Chem 55:765-73. 2009

Research Grants

  1. Thomas W White; Fiscal Year: 2014
  2. PPK Dependent Acidocalcisome-like Granules, Polyphosphates and Helicobacter
    Manfredo J Seufferheld; Fiscal Year: 2010
  3. The role of ppk ion channels in sensory detection
    KRISTIN E SCOTT; Fiscal Year: 2010
  4. Integrated Cheminformatics Resource for Orphan Neurodegenerative Diseases
    Weifan Zheng; Fiscal Year: 2012
  5. PRORENIN: PHYSIOLOGICAL AND BIOCHEMICAL ANALYSIS
    JEAN SEALEY; Fiscal Year: 1980
  6. PPK: Radiation Response and Cell Proliferation
    Peter Stambrook; Fiscal Year: 2006
  7. GENETICS OF POLYPHOSPHATE METABOLISM IN H. PYLORI
    Douglas Berg; Fiscal Year: 2005
  8. CONNEXIN MUTATIONS IN HUMAN SKIN DISEASE
    Thomas White; Fiscal Year: 2001
  9. Crystallographic Studies of Polyphosphate Kinase
    Wenqing Xu; Fiscal Year: 2007
  10. Individual Propensity to Venous Thrombosis
    John Heit; Fiscal Year: 2009

Detail Information

Publications278 found, 100 shown here

  1. ncbi Keratin 9 mutations in the coil 1A region in epidermolytic palmoplantar keratoderma
    S Szalai
    Department of Dermatology, , Budapest, Hungary
    Pediatr Dermatol 16:430-5. 1999
    The palmoplantar keratodermas (PPK) are a heterogeneous group of conditions, most frequently inherited in autosomal dominant fashion...
  2. ncbi Fine mapping of the H-kininogen binding site in plasma prekallikrein apple domain 2
    Thomas Renne
    Institute of Clinical Biochemistry and Pathobiochemistry, Julius Maximilians University at Würzburg, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
    Int Immunopharmacol 2:1867-73. 2002
    b>Plasma prekallikrein (PPK), the zymogen of the contact phase protease plasma kallikrein, forms a non-covalent complex with its substrate H-kininogen (HK)...
  3. ncbi Distribution of 15 human kallikreins in tissues and biological fluids
    Julie L V Shaw
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    Clin Chem 53:1423-32. 2007
    ..We characterized the protein and mRNA abundance patterns of all 15 KLKs in multiple panels of human tissues and biological fluids...
  4. ncbi Identification of putative serum glycoprotein biomarkers for human lung adenocarcinoma by multilectin affinity chromatography and LC-MS/MS
    Sun Hee Heo
    Department of Biochemistry, School of Dentistry, Kyungpook National University, Daegu, Korea
    Proteomics 7:4292-302. 2007
    ..In addition, plasma kallikrein (KLKB1) and inter-alpha-trypsin inhibitor heavy chain 3 (ITI-H3) were identified as being potentially ..
  5. ncbi Kallikrein gene expression in human pituitary tissues
    J A Clements
    Prince Henry s Institute of Medical Research, St Vincent s Hospital, Victoria, Australia
    Clin Endocrinol (Oxf) 44:223-31. 1996
    ..characterized in the human: glandular kallikrein (KLK1) and two genes expressed in the prostate, KLK2 or hGK1 and KLK3 or prostate specific antigen (PSA)...
  6. ncbi Mal de Meleda (MDM) caused by mutations in the gene for SLURP-1 in patients from Germany, Turkey, Palestine, and the United Arab Emirates
    Katja Martina Eckl
    Gene Mapping Centre and Department of Molecular Genetics, Max Delbrück Centre Moecular Medicine, Berlin, Germany
    Hum Genet 112:50-6. 2003
    ..transgrediens of Siemens is an autosomal recessive skin disorder characterized by diffuse palmoplantar keratoderma (PPK) and transgressive keratosis with an onset in early infancy...
  7. ncbi A novel mutation and large size polymorphism affecting the V2 domain of keratin 1 in an African-American family with severe, diffuse palmoplantar keratoderma of the ichthyosis hystrix Curth-Macklin type
    Elizabeth S Richardson
    Department of Dermatology and Cutaneous Biology, The Jefferson Institute of Molecular Medicine, Jefferson Medical College, Philadelphia, Pennsylvania, USA
    J Invest Dermatol 126:79-84. 2006
    ..circinate erythema (frameshift mutation c1649delG in the V2 domain of keratin 5), striate palmoplantar keratoderma (PPK), and ichthyosis hystrix Curth-Macklin (different frameshift mutations in the V2 domain of keratin 1 (K1))...
  8. ncbi Characterization of androgen receptor and nuclear receptor co-regulator expression in human breast cancer cell lines exhibiting differential regulation of kallikreins 2 and 3
    Angeliki Magklara
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    Int J Cancer 100:507-14. 2002
    ..We examined previously the steroid hormone regulation of 2 known androgen-regulated kallikreins, KLK3 (encoding PSA) and KLK2 (encoding human kallikrein 2 or hK2) in BT-474, T-47D, ZR75-1, MCF-7, MFM-223 and BT-20 ..
  9. pmc The phosphoinositide kinase PIKfyve/Fab1p regulates terminal lysosome maturation in Caenorhabditis elegans
    Anne Sophie Nicot
    Department of Molecular Pathology, Institut National de la Santé et de la Recherche Médicale U596, Centre National de la Recherche Scientifique Unité Mixte de Recherche 7104, Universite Louis Pasteur de Strasbourg, Illkirch, France
    Mol Biol Cell 17:3062-74. 2006
    ..We studied the roles of phosphatidylinositol phosphate kinase 3 (PPK-3), the orthologue of PIKfyve/Fab1p, in a multicellular organism, Caenorhabditis elegans...
  10. pmc Circulating prostate tumor cells detected by reverse transcription-PCR in men with localized or castration-refractory prostate cancer: concordance with CellSearch assay and association with bone metastases and with survival
    Pauliina Helo
    Departments of Surgery Urology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Clin Chem 55:765-73. 2009
    ..localized prostate cancer or castration-refractory prostate cancer (CRPC) for CTCs via real-time RT-PCR assays for KLK3 [kallikrein-related peptidase 3; i.e., prostate-specific antigen (PSA)] and KLK2 mRNAs...
  11. doi Kallikreins on steroids: structure, function, and hormonal regulation of prostate-specific antigen and the extended kallikrein locus
    Mitchell G Lawrence
    Australian Prostate Cancer Research Centre Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
    Endocr Rev 31:407-46. 2010
    ..The kallikrein family is also emerging as a rich source of disease biomarkers with KLK3, commonly known as prostate-specific antigen, being the current serum biomarker for prostate cancer...
  12. pmc Evolutionary history of tissue kallikreins
    Athanasia Pavlopoulou
    Department of Pharmacy, School of Health Sciences, University of Patras, Rion Patras, Greece
    PLoS ONE 5:e13781. 2010
    ..Currently, the most widely known KLK is KLK3 or prostate-specific antigen (PSA) that has applications in clinical diagnosis and monitoring of prostate cancer...
  13. ncbi Palmoplantar keratoderma and leukokeratosis anogenitalis: the second case of a new disease
    S Lautenschlager
    Outpatient Clinic of Dermatology, Triemli Hospital Zurich, Switzerland
    Dermatology 197:300-2. 1998
    An increasing number of syndromes with palmoplantar keratoderma (PPK) with associated diseases are being identified, representing a wide spectrum of distinct entities...
  14. ncbi Identification of Brucella melitensis 16M genes required for bacterial survival in the caprine host
    Michel S Zygmunt
    UR 1282, Unité de recherche Infectiologie Animale et Santé Publique, Institut National de la Recherche Agronomique, 3738 Nouzilly, France
    Microbes Infect 8:2849-54. 2006
    ..coding for the basal-body rod of the flagellar apparatus, and another with a disruption in a gene homologous to ppk which is involved in the biosynthesis of inorganic polyphosphate (PolyP) from ATP...
  15. ncbi [Severe prekallikrein deficiency due to a compound heterozygosis in the KLKB1-gene]
    Bernhard Maak
    Praxis für Kinder und Jugendmedizin im MVZ der Thüringen Kliniken Saalfeld, Pössneck
    Hamostaseologie 29:187-9. 2009
    ..There are two brothers of the propositus, one with normal prekallikrein activity and no mutations in the KLKB1-gene, the other showed the same constellation as the propositus.
  16. ncbi Down-regulation of the human kallikrein gene 5 (KLK5) in prostate cancer tissues
    George M Yousef
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    Prostate 51:126-32. 2002
    ..genes are differentially expressed in various malignancies and prostate specific antigen (PSA; encoded by the KLK3 gene) is the best tumor marker for prostate cancer...
  17. ncbi Molecular cloning of the human kallikrein 15 gene (KLK15). Up-regulation in prostate cancer
    G M Yousef
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    J Biol Chem 276:53-61. 2001
    ..This new gene maps to chromosome 19q13.4 and is located between the KLK1 and KLK3 genes...
  18. ncbi Kallikrein 4 is a predominantly nuclear protein and is overexpressed in prostate cancer
    Zhijun Xi
    Department of Biology, University of Oslo, Oslo, Norway
    Cancer Res 64:2365-70. 2004
    ..For example, prostate-specific antigen (or KLK3) is a secreted protein that is widely used as a diagnostic marker for prostate cancer...
  19. doi Kallikreins as microRNA targets: an in silico and experimental-based analysis
    Tsz fung F Chow
    Department of Laboratory Medicine, and the Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto M5B 1W8, Canada
    Biol Chem 389:731-8. 2008
    ..KLK10 is the most frequently targeted kallikrein, followed by KLK5 and KLK13. KLK1, KLK3, KLK8 and KLK12 do not have strongly predicted miRNA/KLK interactions...
  20. ncbi Identification of novel human kallikrein-like genes on chromosome 19q13.3-q13.4
    G M Yousef
    Department of Pathology, Mount Sinai Hospital, Toronto, Ontario, Canada
    Anticancer Res 19:2843-52. 1999
    ..4 and currently includes three members: KLK1 or pancreatic/renal kallikrein, KLK2 or human glandular kallikrein and KLK3 or prostate-specific antigen (PSA)...
  21. ncbi Keratin 9 gene mutational heterogeneity in patients with epidermolytic palmoplantar keratoderma
    H C Hennies
    Institut fur Humangenetik, Freie Universitat Berlin, Germany
    Hum Genet 93:649-54. 1994
    ..in the human keratin 9 gene have recently been shown to be involved in the etiology of palmoplantar keratoderma (PPK)...
  22. pmc Identification of a locus for type I punctate palmoplantar keratoderma on chromosome 15q22-q24
    A Martinez-Mir
    Department of Dermatology, Columbia University, New York, NY 10032, USA
    J Med Genet 40:872-8. 2003
    ..Among these disorders, there is an extraordinarily heterogeneous group known as palmoplantar keratodermas (PPK), for which only a few molecular defects have been described...
  23. ncbi The phylogenetic significance of peptidoglycan types: Molecular analysis of the genera Microbacterium and Aureobacterium based upon sequence comparison of gyrB, rpoB, recA and ppk and 16SrRNA genes
    Kathrin Richert
    DSMZ Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH, Mascheroder Weg 1b, 38124 Braunschweig, Germany
    Syst Appl Microbiol 30:102-8. 2007
    ..Analysis of the pkk gene and protein as well as of a concatenate tree, combining sequences of all five genes (total of 3...
  24. ncbi Acquired palmoplantar keratoderma
    Shaily Patel
    Department of Dermatology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Am J Clin Dermatol 8:1-11. 2007
    ..Given the numerous possible underlying causes for acquired PPKs, evaluation of patients presenting with acquired PPK can be a perplexing task...
  25. ncbi [Detection of low-level microorganism by concomitant use of ATP amplification and bioluminescence assay]
    Ying Chen
    School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China
    Wei Sheng Wu Xue Bao 49:826-30. 2009
    ..by bioluminescence assay, the reaction of ATP amplification catalyzed by ADK (adenylate kinase) combined with PPK (polyphosphate kinase) can be employed...
  26. doi The interaction of CYP3A5 polymorphisms along the androgen metabolism pathway in prostate cancer
    Markku H Vaarala
    Department of Pathology, University of Oulu, Oulu, Finland
    Int J Cancer 122:2511-6. 2008
    ..14, 95% confidence interval (CI) 1.35-3.40. Patients with CYP3A5*3/*3 and KLK3 I179T CC/TC genotypes had increased OR 2.30, 95% CI 1.16-4.58 for metastatic disease...
  27. ncbi Polyphosphate kinase affects oxidative stress response by modulating cAMP receptor protein and rpoS expression in Salmonella typhimurium
    Yuanyuan Cheng
    Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, China
    J Microbiol Biotechnol 19:1527-35. 2009
    ..Here, we show that deletion of polyphosphate kinase (PPK), the principal enzyme responsible for synthesis of polyP, resulted in augmented expression of cAMP receptor ..
  28. pmc Repression of antibiotic production and sporulation in Streptomyces coelicolor by overexpression of a TetR family transcriptional regulator
    Delin Xu
    Group Métabolisme Energétique des Streptomyces, Institut de Genetique et Microbiologie, UMR CNRS 8621, Universite Paris Sud 11, 91405 Orsay Cedex, France
    Appl Environ Microbiol 76:7741-53. 2010
    ..coelicolor and of the ppk mutant strain of S. lividans...
  29. pmc Multiple kallikrein (KLK 5, 7, 8, and 10) expression in squamous cell carcinoma of the oral cavity
    Jason R Pettus
    Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, MO 65212, USA
    Histol Histopathol 24:197-207. 2009
    ..Control experiments show lack of reactivity against KLK3 (prostate specific antigen)...
  30. doi Robust microRNA stability in degraded RNA preparations from human tissue and cell samples
    Monika Jung
    Department of Urology, University Hospital Charite, Berlin, Germany
    Clin Chem 56:998-1006. 2010
    ..We evaluated this issue by comparative analysis of the dependence of miRNA and mRNA measurements on RNA integrity in renal and prostate samples, under both model and clinical conditions...
  31. ncbi The polyphosphate kinase gene of Escherichia coli. Isolation and sequence of the ppk gene and membrane location of the protein
    M Akiyama
    Department of Biochemistry, Stanford University School of Medicine, California 94305 5307
    J Biol Chem 267:22556-61. 1992
    Polyphosphate kinase (PPK) catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (Ahn, K., and Kornberg, A. (1990) J. Biol. Chem. 265, 11734-11739)...
  32. ncbi An exopolyphosphatase of Escherichia coli. The enzyme and its ppx gene in a polyphosphate operon
    M Akiyama
    Department of Biochemistry, Stanford University School of Medicine, California 94305 5307
    J Biol Chem 268:633-9. 1993
    ..novel exopolyphosphatase of 513 amino acids (58,133 Da) was found downstream of the gene for polyphosphate kinase, ppk. Transcription of the ppx gene depends on the ppk promoters, indicating a polyphosphate (polyP) operon of ppk and ..
  33. ncbi Polyphosphate kinase is a component of the Escherichia coli RNA degradosome
    E Blum
    Nuffield Department of Clinical Biochemistry, Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, UK
    Mol Microbiol 26:387-98. 1997
    ..In this work, we identify an additional component of the degradosome, polyphosphate kinase (PPK), which catalyses the reversible polymerization of the gamma-phosphate of ATP into polyphosphate (poly(P)). An E...
  34. ncbi Localization of a new prostate-specific antigen-related serine protease gene, KLK4, is evidence for an expanded human kallikrein gene family cluster on chromosome 19q13.3-13.4
    S A Stephenson
    Centre for Molecular Biotechnology, School of Life Sciences, Queensland University of Technology, Brisbane, Australia 4001
    J Biol Chem 274:23210-4. 1999
    ..events, currently consists of just three genes-tissue kallikrein (KLK1), KLK2, and prostate-specific antigen (PSA) (KLK3)-clustered at chromosome 19q13. 3-13.4...
  35. ncbi Identification and characterization of KLK14, a novel kallikrein serine protease gene located on human chromosome 19q13.4 and expressed in prostate and skeletal muscle
    J D Hooper
    Centre for Molecular Biotechnology, Queensland University of Technology, Brisbane, Queensland, 4001, Australia
    Genomics 73:117-22. 2001
    ..is expressed by both benign and malignant glandular epithelial cells, thus exhibiting an expression pattern similar to that of two other prostatic kallikreins, KLK2 and KLK3, which encode K2 and prostate-specific antigen, respectively.
  36. ncbi Pharmacokinetic modeling of disposition and time-course studies with [14C]atrazine
    Tami S McMullin
    Department of Environmental and Radiological Health Sciences, Colorado State University, Ft Collins, CO 80523, USA
    J Toxicol Environ Health A 66:941-64. 2003
    A physiological pharmacokinetic (PPK) model, with blood, body, and brain compartments, was developed to estimate total plasma chlorotriazine (CI-TRI) time courses (i.e...
  37. ncbi Role of androgen metabolism genes CYP1B1, PSA/KLK3, and CYP11alpha in prostate cancer risk and aggressiveness
    Mine S Cicek
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Lerner School of Medicine, Ohio, USA
    Cancer Epidemiol Biomarkers Prev 14:2173-7. 2005
    ..metabolism: CYP1B1 (two single nucleotide polymorphisms: 355G/T and 4326C/G), prostate-specific antigen (PSA/KLK3 (three single nucleotide polymorphisms: -158A/G, -4643G/A, and -5412C/T), and CYP11alpha [(tttta)(n) repeat], using ..
  38. ncbi The transcriptional regulatory strategy of the rat tissue kallikrein gene family
    E Kroon
    Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75235 9140, USA
    Genes Funct 1:309-19. 1997
    ..Rat (r) genes KLK1, KLK2, KLK3, KLK7, KLK8, KLK9 and KLK10 on four different P1 clones were all correctly expressed at high levels in the ..
  39. ncbi [Dermatomyositis and punctate porokeratotic keratoderma as paraneoplastic syndrome of ovarian carcinoma]
    R Valverde
    Servicio de Dermatologia, Hospital Universitario 12 de Octubre, Madrid
    Actas Dermosifiliogr 98:358-60. 2007
    ..Punctate porokeratotic keratoderma (PPK) is a type of punctate keratoderma mainly defined by its peculiar histological features, including the presence of ..
  40. doi Novel splice variants of prostate-specific antigen and applications in diagnosis of prostate cancer
    Georgios Pampalakis
    Department of Pharmacy, University of Patras, Rion Patras 26500, Greece
    Clin Biochem 41:591-7. 2008
    We aimed to identify novel splice variants of prostate-specific antigen/or human kallikrein 3 (PSA/KLK3), the most widely used serum biomarker for case-finding, screening and monitoring of prostate cancer.
  41. doi Major role of human KLK14 in seminal clot liquefaction
    Nashmil Emami
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5G 1L5, Canada
    J Biol Chem 283:19561-9. 2008
    ..Among these, KLK3 (also known as prostate-specific antigen) is the main executor enzyme responsible for processing of the primary ..
  42. doi Meropenem pharmacokinetics, pharmacodynamics, and Monte Carlo simulation in the neonate
    John S Bradley
    Division of Infectious Diseases, Children s Hospital and Health Center, San Diego, CA 92123, USA
    Pediatr Infect Dis J 27:794-9. 2008
    ..Hospitalized neonates are exposed to antibiotic-resistant bacterial pathogens and develop nosocomial infections. Limited data are available regarding the neonatal pharmacokinetics of meropenem, a broad spectrum carbapenem antibiotic...
  43. pmc Control of the postmating behavioral switch in Drosophila females by internal sensory neurons
    Chung Hui Yang
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuron 61:519-26. 2009
    ..to produce behavioral changes, we found that six to eight sensory neurons on the reproductive tract labeled by both ppk-GAL4 and fruitless-GAL4 can sense sex peptide to control the induction of postmating behaviors...
  44. doi Genetic variants associated with deep vein thrombosis: the F11 locus
    Y Li
    Celera, Alameda, CA, USA
    J Thromb Haemost 7:1802-8. 2009
    ..2 locus that contains genes encoding factor XI (F11), a cytochrome P450 family member (CYP4V2), and prekallikrein (KLKB1).
  45. pmc Novel biomarkers for prostate cancer including noncoding transcripts
    Tammy L Romanuik
    Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, Canada
    Am J Pathol 175:2264-76. 2009
    ..Expression of GLO1, DHCR24, NGFRAP1, KLK3, and RAMP1 were significantly decreased in metastatic castration-recurrent disease compared with androgen-dependent ..
  46. doi Activation of the plasma kallikrein-kinin system on human lung epithelial cells
    Julius F Varano della Vergiliana
    School of Biomedical, Biomolecular and Chemical Sciences, University of Western Australia, 35 Stirling Highway, Perth 6009, Western Australia, Australia
    Biol Chem 391:1067-77. 2010
    ..Plasma KKS involves assembly and activation of high molecular weight kininogen (HK) and plasma prekallikrein (PPK) on cell surfaces, resulting in the liberation of the inflammatory peptide, bradykinin (BK), from HK ..
  47. pmc Phacomatosis pigmentokeratotica without extracutaneous abnormalities: a case study involving a preterm baby
    Ga Na Oh
    Department of Dermatology, Korea University College of Medicine, Seoul, Korea
    J Korean Med Sci 27:1444-6. 2012
    Phacomatosis pigmentokeratotica (PPK) is a rare syndrome defined by the association of an organoid nevus occasionally with sebaceous differentiation, a speckled lentiginous nevus, and other extracutaneous anomalies...
  48. doi Verification of enzymes deterioration due to Cu(II) presence in an enhanced biological phosphorus removal system
    Yung Pin Tsai
    Department of Civil Engineering, National Chi Nan University, Puli, Nantou 545, Taiwan
    Chemosphere 91:602-7. 2013
    ..presence was due to the inhibition of enzyme activities of acetyl-CoA synthases (ACS) and polyphosphate kinase (PPK), respectively...
  49. pmc Possible nagashima-type palmoplantar keratosis in two siblings
    Kio Park
    Department of Dermatology, Yamato Takada Municipal Hospital, Nara, Kyoto, Japan
    Case Rep Dermatol 5:58-60. 2013
    Nagashima-type palmoplantar keratosis (PPK) is an autosomal recessive, transgressive and non-progressive form of PPK. It was once described as a mild form of mal de Meleda, but it is now proposed as a novel entity of PPK...
  50. doi Sexually dimorphic octopaminergic neurons modulate female postmating behaviors in Drosophila
    Carolina Rezaval
    Department of Physiology, Anatomy, and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford OX1 3PT, UK Electronic address
    Curr Biol 24:725-30. 2014
    ..3-6] via SP sensory neurons in the uterus defined by coexpression of the proprioceptive neuronal marker pickpocket (ppk) and the sex-determination genes doublesex (dsx) and fruitless (fru) [7-9]...
  51. pmc Enhancer RNAs participate in androgen receptor-driven looping that selectively enhances gene activation
    Chen Lin Hsieh
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 111:7319-24. 2014
    ..Kallikrein-related peptidase 3 (KLK3), which codes for prostate-specific antigen (PSA), is a well-known AR-regulated gene and its upstream enhancers ..
  52. pmc Structure-function analyses of human kallikrein-related peptidase 2 establish the 99-loop as master regulator of activity
    Wolfgang Skala
    From the Division of Structural Biology, Department of Molecular Biology, University of Salzburg, A 5020 Salzburg, Austria
    J Biol Chem 289:34267-83. 2014
    ..Most likely it activates and complements chymotryptic KLK3 (prostate-specific antigen) in cleaving seminal clotting proteins, resulting in sperm liquefaction...
  53. pmc Population pharmacokinetics of high-dose methotrexate after intravenous administration in Chinese osteosarcoma patients from a single institution
    Wei Zhang
    Department of Clinical Pharmacology, Beijing Jishuitan Hospital, Beijing 100035, China
    Chin Med J (Engl) 128:111-8. 2015
    ..The goals of this study were to establish the population pharmacokinetics (PPK) of HD-MTX treatment in Chinese osteosarcoma patients, and to explore the influence of patient covariates and ..
  54. pmc Associations of prostate cancer risk variants with disease aggressiveness: results of the NCI-SPORE Genetics Working Group analysis of 18,343 cases
    Brian T Helfand
    Department of Surgery, Division of Urology, John and Carol Walter Center for Urological Health, NorthShore University Health System, Evanston, IL, USA
    Hum Genet 134:439-50. 2015
    ..Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC...
  55. doi miRSNP-Based Approach Identifies a miRNA That Regulates Prostate-Specific Antigen in an Allele-Specific Manner
    George M Yousef
    Department of Laboratory Medicine, and the Keenan Research Centre for Biomedical Science at the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Cancer Discov 5:351-2. 2015
    ..The authors also undertook functional validation studies and were able to demonstrate that overexpression of miR-3162-5p resulted in a 20% decrease in expression of the KLK3 rs1058205 SNP T-allele.
  56. doi An integrative population pharmacokinetics approach to the characterization of the effect of hepatic impairment on clobazam pharmacokinetics
    Dwain Tolbert
    Lundbeck LLC, Deerfield, IL, USA
    J Clin Pharmacol 56:213-22. 2016
    An integrative population pharmacokinetics (PPK)-based approach was used to characterize the effect of hepatic impairment on clobazam PK and its major metabolite in systemic circulation, N-desmethylclobazam (N-CLB)...
  57. pmc Involvement of polyphosphate kinase in virulence and stress tolerance of uropathogenic Proteus mirabilis
    Liang Peng
    Department of Clinical Laboratory, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China
    Med Microbiol Immunol 205:97-109. 2016
    ..However, the functions of polyphosphate kinase (PPK), which are related to the pathogenicity of many bacteria, remain entirely unknown in P. mirabilis...
  58. doi The kallikrein-related peptidase family: Dysregulation and functions during cancer progression
    T Kryza
    Australian Prostate Cancer Research Centre Queensland, Translational Research Institute, 37 Kent Street, Woolloongabba, QLD 4102, Brisbane, Australia Institute of Health and Biomedical Innovation, Translational Research Institute, Queensland University of Technology, Brisbane, Australia
    Biochimie 122:283-99. 2016
    ..The potential of KLKs as cancer biomarkers is well established since the demonstration of the association between KLK3/PSA (prostate specific antigen) levels and prostate cancer progression...
  59. doi Population pharmacokinetics of vancomycin in adult Chinese patients with post-craniotomy meningitis and its application in individualised dosage regimens
    Wei Wei Lin
    Department of Pharmacy, The First Affiliated Hospital, Fujian Medical University, 20 Cha Zhong M Rd, Taijiang, Fuzhou, 350005, People s Republic of China
    Eur J Clin Pharmacol 72:29-37. 2016
    ..Although VCM population pharmacokinetics (PPK) has been reported, changes in VCM PPK in adult Chinese PCM patients remain unknown...
  60. pmc Incorporating Known Genetic Variants Does Not Improve the Accuracy of PSA Testing to Identify High Risk Prostate Cancer on Biopsy
    Rebecca Gilbert
    School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
    PLoS ONE 10:e0136735. 2015
    ..circulating PSA levels rather than with prostate cancer risk (TERT rs2736098, FGFR2 rs10788160, TBX3 rs11067228, KLK3 rs17632542)...
  61. pmc Utilization of Whole-Cell MALDI-TOF Mass Spectrometry to Differentiate Burkholderia pseudomallei Wild-Type and Constructed Mutants
    Suthamat Niyompanich
    Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok, Thailand
    PLoS ONE 10:e0144128. 2015
    ..Candidate biomarkers for the B. pseudomallei mutants, including rpoS, ppk, and bpsI isolates, were determined. Taxon-specific and clinical isolate-specific biomarkers of B...
  62. doi Mono-2-ethyhexyl phthalate advancing the progression of prostate cancer through activating the hedgehog pathway in LNCaP cells
    Wang Yong
    WHO Collaborating Center for Research in Human Reproduction, Shanghai Institute of Planned Parenthood Research, Shanghai 200030, China
    Toxicol In Vitro 32:86-91. 2016
    ..Results showed that the expression of the critical gene of Hh pathway PTCH and androgen-regulated gene KLK3 was significantly decreased on 3, 6 and 9 days with Hh pathway inhibitor cyclopamine's treatment...
  63. doi Optimal dosing regimen of biapenem in Chinese patients with lower respiratory tract infections based on population pharmacokinetic/pharmacodynamic modelling and Monte Carlo simulation
    Jing Dong
    Department of Pharmacy, Gongli Hospital of Pudong New Area in Shanghai, Shanghai, China Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China
    Int J Antimicrob Agents 47:202-9. 2016
    In this study, a population pharmacokinetic (PPK) model of biapenem in Chinese patients with lower respiratory tract infections (LRTIs) was developed and optimal dosage regimens based on Monte Carlo simulation were proposed...
  64. doi Hereditary palmoplantar keratoderma "clinical and genetic differential diagnosis"
    Tomo Sakiyama
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Dermatol 43:264-74. 2016
    Hereditary palmoplantar keratoderma (PPK) is a heterogeneous group of disorders characterized by hyperkeratosis of the palm and the sole skin...
  65. pmc A Cross-sectional Study of KLKB1 and PRCP Polymorphisms in Patient Samples with Cardiovascular Disease
    Haley R Gittleman
    Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA
    Front Med (Lausanne) 3:17. 2016
    b>Plasma kallikrein formed from prekallikrein (PK) produces bradykinin from kininogens and activates factor XII. Plasma PK is activated by factors αXIIa, βXIIa, or prolylcarboxypeptidase (PRCP)...
  66. pmc Huriez syndrome with superadded dermatophyte infection
    Trupti Surana
    Department of Dermatology, GMERS Medical College, Civil Hospital, Gandhinagar, Gujarat, India
    Indian Dermatol Online J 7:288-9. 2016
    ..Huriez syndrome is a rare autosomal dominant transgradient type of PPK with high frequency of squamous cell carcinoma in the affected skin...
  67. pmc Montelukast in the treatment of perennial allergic rhinitis in paediatric Japanese patients; an open-label clinical trial
    Kimihiro Okubo
    Department of Otorhinolaryngology, Nippon Medical School Hospital, Tokyo, Japan
    J Drug Assess 5:6-14. 2016
    ..b>Background: This study was conducted to evaluate the safety and tolerability, and population pharmacokinetics (PPK) of montelukast as well as efficacy in the treatment of perennial allergic rhinitis (PAR) in paediatric Japanese ..
  68. pmc The Hematologic Definition of Monoclonal Gammopathy of Undetermined Significance in Relation to Paraproteinemic Keratopathy (An American Ophthalmological Society Thesis)
    Walter Lisch
    Department of Ophthalmology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany Dr W Lisch, Dr Wasielica Poslednik the Department of Ophthalmology, Helsinki University Central Hospital, Helsinki, Finland Dr Kivelä the Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany Dr Schlötzer Schrehardt the Department of Ophthalmology, Eberhard Karls University of Tubingen, Tubingen, Germany Dr Rohrbach the Department of Ophthalmology, University of Marburg, Marburg, Germany Dr Sekundo the Department of Ophthalmology, Campus Virchow Klinikum, Charite Universitaetsmedizin Berlin, Berlin, Germany Dr Pleyer the private practice of ophthalmology Hanau, Hanau, Germany Dr C Lisch the Department of Internal Medicine III, Johannes Gutenberg University Mainz, Mainz, Germany Dr Desuki the Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Mainz, Mainz, Germany Dr Rossmann and the Department of Ophthalmology, Louisiana State University Health Sciences Center, School of Medicine, New Orleans, Louisiana Dr Weiss
    Trans Am Ophthalmol Soc 114:T7. 2016
    To determine if paraproteinemic keratopathy (PPK) in the setting of monoclonal gammopathy of undetermined significance (MGUS) causes distinct patterns of corneal opacification that can be distinguished from hereditary, immunologic, or ..
  69. doi Population pharmacokinetic models of lamotrigine in different age groups of Chinese children with epilepsy
    Zhong Bin Zhang
    Department of Pediatrics, Peking University First Hospital, No 1 Xi An Men Street, West District, Beijing, 100034, China
    Eur J Clin Pharmacol . 2017
    The study aims to establish population pharmacokinetic (PPK) models of lamotrigine (LTG) in different age groups of epileptic children by nonlinear mixed effect modelling(NONMEM), and provide essential tools and theoretical basis for ..
  70. ncbi Polyphosphate kinase from Escherichia coli. Purification and demonstration of a phosphoenzyme intermediate
    K Ahn
    Department of Biochemistry, Stanford University School of Medicine, California 94305 5307
    J Biol Chem 265:11734-9. 1990
    Polyphosphate kinase (PPK) polymerizes the terminal phosphate of ATP to a long chain polyphosphate (poly(P) or (Pi)n) in a freely reversible reaction (Kornberg, S. R. (1957) Biochim. Biophys...
  71. pmc Ripped pocket and pickpocket, novel Drosophila DEG/ENaC subunits expressed in early development and in mechanosensory neurons
    C M Adams
    Howard Hughes Medical Institute, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Cell Biol 140:143-52. 1998
    ..We identified two novel Drosophila DEG/ ENaC proteins, Pickpocket (PPK) and Ripped Pocket (RPK). Both appear to be ion channel subunits...
  72. ncbi Low-copy plasmids can perform as well as or better than high-copy plasmids for metabolic engineering of bacteria
    K L Jones
    Department of Chemical Engineering, University of California, Berkeley, California 94720 1462, USA
    Metab Eng 2:328-38. 2000
    ..80% when either high- or low-copy plasmids were used, from 120 micromol/g DCW without augmented polyP kinase (PPK) activity to approximately 220 micromol/g DCW...
  73. ncbi Non-small-cell lung cancer with nonfamilial diffuse palmoplantar keratoderma
    H Engin
    Dept of Medical Oncology, Hacettepe University, Institute of Oncology, Ankara, Turkey
    J Exp Clin Cancer Res 21:45-7. 2002
    Palmoplantar keratoderma (PPK) is a congenital or acquired disorder characterized by the abnormal thickening of the skin of the palms and soles. The thickening can present as a diffuse, focal or punctate pattern...
  74. ncbi Crystallization and characterization of polyphosphate kinase from Escherichia coli
    Ye Zhu
    Department of Biological Structure, University of Washington, Seattle, WA 98195, USA
    Biochem Biophys Res Commun 305:997-1001. 2003
    ..Polyphosphate kinase (PPK) is a critical enzyme responsible for polyphosphate synthesis in bacteria...
  75. ncbi Model appropriateness and population pharmacokinetic modeling
    Ene I Ette
    Vertex Pharmaceutical, Inc, Cambridge, Massachusetts, USA
    J Clin Pharmacol 43:610-23. 2003
    ..and to set out a framework within which model appropriateness could be determined for population pharmacokinetic (PPK) models...
  76. ncbi Relative concentrations of hK2/PSA mRNA in benign and malignant prostatic tissue
    Susanna Lintula
    Department of Clinical Chemistry, Helsinki University Central Hospital, Helsinki, Finland
    Prostate 63:324-9. 2005
    Prostate-specific antigen (PSA/KLK3) and human kallikrein 2 (hK2/KLK2) belong to the human kallikrein gene family. These two highly homologous genes are specifically expressed in the prostate under androgen control...
  77. ncbi Polyphosphate kinase: a new colonization factor of Helicobacter pylori
    Sarah Ayraud
    EA3807, Laboratoire de Microbiologie A, CHU La Milétrie and UFR de Médecine et Pharmacie, Universite de Poitiers, BP 577, 86021 Poitiers Cedex, France
    FEMS Microbiol Lett 243:45-50. 2005
    In order to elucidate the role of polyphosphate kinase (PPK) during the course of an infection by Helicobacter pylori, PPK deficient mutants were constructed using two genetic backgrounds: Hp141v and X47-2AL...
  78. pmc Polyphosphate kinase protects Salmonella enterica from weak organic acid stress
    Marian Price-Carter
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    J Bacteriol 187:3088-99. 2005
    Mutants of Salmonella enterica lacking polyphosphate kinase (ppk) grow poorly in the presence of the weak organic acids acetate, propionate, and benzoate...
  79. pmc Sequence-based typing of genetic targets encoded outside of the O-antigen gene cluster is indicative of Shiga toxin-producing Escherichia coli serogroup lineages
    Matthew W Gilmour
    National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington Street, Winnipeg, Manitoba R3E 3R2, Canada
    J Med Microbiol 56:620-8. 2007
    ..Segments of the core bacterial loci mdh, gnd, gcl, ppk, metA, ftsZ, relA and metG for 30 O26 STEC strains have previously been sequenced, and comparative analyses to O157 ..
  80. doi "Nagashima-type" keratosis as a novel entity in the palmoplantar keratoderma category
    Kenji Kabashima
    Department of Dermatology, University of Environmental and Occupational Health, 1 1 Iseigaka Yahatanishi ku, Kitakyushu, Fu 807 8555, Japan
    Arch Dermatol 144:375-9. 2008
    Nagashima-type" keratosis is characterized by transgressive and nonprogressive palmoplantar keratoderma (PPK) with an autosomal recessive trait...
  81. ncbi [Population pharmacokinetics of lamotrigine in Chinese children with epilepsy]
    Shen Zhang
    Department of Pediatrics, Peking University First Hospital, Beijing 100034, China
    Zhongguo Dang Dai Er Ke Za Zhi 10:105-9. 2008
    To establish a population pharmacokinetics (PPK) model of lamotrigine, an antiepileptic drug, in Chinese children with epilepsy to formulate an individualized dosage guideline.
  82. pmc Active plasma kallikrein localizes to mast cells and regulates epithelial cell apoptosis, adipocyte differentiation, and stromal remodeling during mammary gland involution
    Jennifer N Lilla
    Department of Anatomy, University of California, San Francisco, California 94143 0452, USA
    J Biol Chem 284:13792-803. 2009
    ..to plasmin by urokinase-type plasminogen activator (uPA), tissue-type plasminogen activator (tPA), and plasma kallikrein (PKal)...
  83. ncbi [Integration and expression of polyphosphate kinase gene in Pseudomonas putida]
    Hong wei Du
    State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210093, China
    Huan Jing Ke Xue 30:3011-5. 2009
    In order to construct high accumulating-phosphate microorganism, the ppk gene from E. coli was inserted to the broad-host-range plasmid pBBR1MCS-2 to form plasmid pBBR1MCS-2-ppk...
  84. doi Dehydroepiandrosterone-induced proliferation of prostatic epithelial cell is mediated by NFKB via PI3K/AKT signaling pathway
    Hong Zhi Sun
    Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, School of Medicine, Xi an Jiaotong University, Xi an, People s Republic of China
    J Endocrinol 204:311-8. 2010
    ..cells were used to determine whether DHEA-modulated proliferation and prostate-specific antigen (PSA listed as KLKB1 in the MGI Database) production were mediated via the androgen receptor (AR) and its potential mechanism...
  85. doi Kallikrein-related peptidase genes as promising biomarkers for prognosis and monitoring of human malignancies
    Margaritis Avgeris
    Department of Biochemistry and Molecular Biology, University of Athens, Greece
    Biol Chem 391:505-11. 2010
    ..diagnosis, prognosis and monitoring of cancer patients, as it is strongly emphasized by the routine use of PSA (KLK3) for prostate cancer management...
  86. pmc Susceptibility loci associated with prostate cancer progression and mortality
    David J Gallagher
    Department of Medicine, Clinical Genetics Service, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Albert Einstein College of Medicine, New York, New York 10065, USA
    Clin Cancer Res 16:2819-32. 2010
    ..Prostate cancer is a heterogeneous disease with a variable natural history that is not accurately predicted by currently used prognostic tools...
  87. doi Mapping of a novel locus for an autosomal recessive form of palmoplantar keratoderma on chromosome 3q27.2-q29
    S Khan
    Department of Biochemistry, Faculty of Biological Sciences, Quaid i Azam University, Islamabad, Pakistan
    Br J Dermatol 163:711-8. 2010
    ..The present study describes clinical and molecular genetic analysis of a consanguineous Pakistani family showing a severe form of PPK inherited in an autosomal recessive manner.
  88. pmc Plasma prekallikrein levels are positively associated with circulating lipid levels and the metabolic syndrome in children
    James A MacKenzie
    Department of Biological Sciences, State University of New York College at Oswego, Oswego, NY 13126, USA
    Appl Physiol Nutr Metab 35:518-25. 2010
    b>Plasma prekallikrein (PK) has been shown to be associated with cardiovascular disease (CVD) and its risk factors, but these associations have not been investigated in children...
  89. doi Population pharmacokinetic analysis of glimepiride with CYP2C9 genetic polymorphism in healthy Korean subjects
    Hee Doo Yoo
    College of Pharmacy and Institute of Bioequivalence and Bridging Study, Chonnam National University, 300 Yongbong Dong, Buk Gu, Gwangju, 500 757, South Korea
    Eur J Clin Pharmacol 67:889-98. 2011
    The purpose of this study was to develop a population pharmacokinetic (PPK) model of glimepiride and to investigate the influence of genetic polymorphisms in CYP2C9 on the PPK of glimepiride in healthy Korean subjects.
  90. ncbi [Experimental effect of a shot caused by 4.5 mm cartridges fired from a Norica Dragon air-rifle and a Walther PPK/S air-pistol]
    Anna Smedra-Kaźmirska
    Zakładu Medycyny Sadowej, Uniwersytetu Medycznego w Łodzi
    Arch Med Sadowej Kryminol 60:77-82. 2010
    ..In this study we presented experimental effects of shooting pneumatic weapons (Norica Dragon air-rifle and Walther PPK/S air-pistol) which had kinetic energy of fired projectiles below 17 J...
  91. pmc Effects of the demethylating agent, 5-azacytidine, on expression of the kallikrein-kinin genes in carcinoma cells of the lung and pleura
    Joshua Wong
    Lung Institute of Western Australia and Centre for Asthma, Allergy and Respiratory Research, The University of Western Australia, Ground Floor, E Block, Sir Charles Gairdner Hospital, Perth, WA 6009, Australia
    Patholog Res Int 2011:167046. 2011
    Tissue kallikrein (KLK1) and plasma kallikrein (KLKB1) may regulate the growth and proliferation of tumours of the lung and pleura, through the generation of kinin peptides that signal through the kinin B(1) (BDKRB1) and B(2) (BDKRB2) ..
  92. pmc Dynamic nucleosome-depleted regions at androgen receptor enhancers in the absence of ligand in prostate cancer cells
    Claudia Andreu-Vieyra
    Department of Urology, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
    Mol Cell Biol 31:4648-62. 2011
    ..We investigated nucleosome positioning at the androgen receptor (AR) enhancers of TMPRSS2, KLK2, and KLK3/PSA in prostate cancer cells...
  93. doi Improved hydrogen production under microaerophilic conditions by overexpression of polyphosphate kinase in Enterobacter aerogenes
    Yuan Lu
    Institute of Biochemical Engineering, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China
    Enzyme Microb Technol 48:187-92. 2011
    ..hydrogen production and cellular metabolism of wild Enterobacter aerogenes strain and polyphosphate kinase (PPK) overexpressing strain were systematically studied in this paper, using NaH(2)PO(4) as the phosphate sources...
  94. doi Population pharmacokinetics of cyclosporine A based on NONMEM in Chinese allogeneic hematopoietic stem cell transplantation recipients
    Hui Zhou
    Department of Clinical Pharmacy, General Hospital of Air Force, PLA, 30 Fucheng Road, Beijing 100142, China
    Eur J Drug Metab Pharmacokinet 37:271-8. 2012
    To set up a population pharmacokinetic (PPK) model of cyclosporine A (CsA) in Chinese allogeneic hematopoietic stem cell transplantation (allo-HSCT) patients to provide reference for individualized medication in clinical practice...
  95. ncbi Assembly of trinuclear and tetranuclear building units of Cu2+ towards two 1D magnetic systems: synthesis and magneto-structural correlations
    Anindita Chakraborty
    Molecular Materials Laboratory, Chemistry and Physics of Materials Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore 560 064, India
    Dalton Trans 41:5879-88. 2012
    Two new 1D coordination polymers, [Cu(3)(μ(3)-OH)(ppk)(3)(μ-N(CN)(2))(OAc)](n) (1) and {[Cu(4)(pdmH)(2)(pdm)(2)(μ(2)-OH)(H(2)O)]·ClO(4)}(n) (2) based on two different blocking ligands phenyl-2-pyridylketoxime (ppk) and pyridine-2,6-..
  96. pmc Polyphosphate degradation in stationary phase triggers biofilm formation via LuxS quorum sensing system in Escherichia coli
    Mariana Grillo-Puertas
    Instituto Superior de Investigaciones Biológicas Consejo Nacional de Investigaciones Científicas y Técnicas Universidad Nacional de Tucumán, and Instituto de Química Biológica Dr Bernabé Bloj Universidad Nacional de Tucumán, San Miguel de Tucuman, Tucuman, Argentina
    PLoS ONE 7:e50368. 2012
    ..No biofilm formation was observed in ppk(-)ppx(-) or ppk(-)ppx(-)/ppk(+) strains, deficient in polyP synthesis and hydrolysis, respectively...
  97. doi Phacomatosis pigmentokeratotica is caused by a postzygotic HRAS mutation in a multipotent progenitor cell
    Leopold Groesser
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    J Invest Dermatol 133:1998-2003. 2013
    Phacomatosis pigmentokeratotica (PPK) is a rare epidermal nevus syndrome characterized by the co-occurrence of a sebaceous nevus and a speckled lentiginous nevus...
  98. doi High level of antibiotic production in a double polyphosphate kinase and phosphate-binding protein mutant of Streptomyces lividans
    Margarita Diaz
    Instituto de Biología Funcional y Genómica Departamento de Microbiología y Genética, Consejo Superior de Investigaciones Científicas CSIC Universidad de Salamanca, Salamanca, Spain
    FEMS Microbiol Lett 342:123-9. 2013
    ..In the present work we obtained and studied a Streptomyces lividans ppk/pstS double mutant, which lacks polyphosphate kinase (PPK) and the high-affinity phosphate-binding protein (PstS), ..
  99. pmc Role of polyphosphate in thermophilic Synechococcus sp. from microbial mats
    María R Gómez-García
    Carnegie Institution for Science, Department of Plant Biology, Stanford University, Stanford, California, USA
    J Bacteriol 195:3309-19. 2013
    ..First, we developed a transformation protocol to create mutants in the polyphosphate kinase (ppk), the major enzyme responsible for the synthesis of poly P...
  100. doi Population pharmacokinetics of ceftaroline in patients with acute bacterial skin and skin structure infections or community-acquired bacterial pneumonia
    Scott A Van Wart
    Institute for Clinical Pharmacodynamics, Latham, NY, USA
    J Clin Pharmacol 53:1155-67. 2013
    ..A population pharmacokinetic (PPK) model for ceftaroline was developed in NONMEM® using data from 185 healthy subjects and 92 patients with acute ..
  101. ncbi [Expert consensus on population pharmacokinetics of Chinese medicine ( draft version for comments)]
    Yan Ming Xie
    Institute of Basic Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China
    Zhongguo Zhong Yao Za Zhi 38:2937-42. 2013
    In population pharmacokinetic (PPK) research of Chinese medicines with narrow therapeutic windows of toxicity, or when the target population is not homogeneous, or when there are frequent adverse reactions to parenterally administered ..

Research Grants25

  1. Thomas W White; Fiscal Year: 2014
    ..deafness, or syndromic deafness associated with a variety of skin disorders including palmoplantar keratoderma (PPK), keratitis- ichthyosis-deafness syndrome (KID), and Vohwinkel syndrome (VS)...
  2. PPK Dependent Acidocalcisome-like Granules, Polyphosphates and Helicobacter
    Manfredo J Seufferheld; Fiscal Year: 2010
    ....
  3. The role of ppk ion channels in sensory detection
    KRISTIN E SCOTT; Fiscal Year: 2010
    ..In Drosophila, there are 29 members of this gene family called pickpocket genes (ppk)...
  4. Integrated Cheminformatics Resource for Orphan Neurodegenerative Diseases
    Weifan Zheng; Fiscal Year: 2012
    ..The second tool (SB-PPK) generates structure-based descriptors for organic molecules...
  5. PRORENIN: PHYSIOLOGICAL AND BIOCHEMICAL ANALYSIS
    JEAN SEALEY; Fiscal Year: 1980
    ..shown that plasma prorenin can be converted to active renin following incubation with urinary kallikrein, plasma kallikrein or plasmin...
  6. PPK: Radiation Response and Cell Proliferation
    Peter Stambrook; Fiscal Year: 2006
    ..abstract_text> ..
  7. GENETICS OF POLYPHOSPHATE METABOLISM IN H. PYLORI
    Douglas Berg; Fiscal Year: 2005
    ..for traits such as stress resistance, motility and virulence; and that polyP is made by polyphosphate kinases (PPK), and consumed by PPK or an exopolyphosphatase (PPX)...
  8. CONNEXIN MUTATIONS IN HUMAN SKIN DISEASE
    Thomas White; Fiscal Year: 2001
    ..have been elucidated by the discovery of mutations in human connexin genes underlying palmoplantar keratodoma (PPK) and erythrokeratodermia variabilis (EKV)...
  9. Crystallographic Studies of Polyphosphate Kinase
    Wenqing Xu; Fiscal Year: 2007
    ..Polyphosphate kinase (PPK) is an enzyme responsible for the reversible synthesis of poly(P) from ATP...
  10. Individual Propensity to Venous Thrombosis
    John Heit; Fiscal Year: 2009
    ..However, the incidence of VTE has remained relatively constant at about 1 per 1000 since 1980. Clearly, better methods of targeting VTE prophylaxis are needed. ..
  11. KALLIKREINS AS DIAGNOSTIC MARKERS OF OVARIAN CARCINOMA
    Eleftherios Diamandis; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  12. Thrombostatin-A Thrombin Receptor Inhibitor
    Alvin Schmaier; Fiscal Year: 2006
    ..Second, the preparation of an IND application for its human use for one indication will be achieved. Thrombostatin(tm) has the opportunity to be a first-in-its-class thrombin receptor activation antagonist. [unreadable] [unreadable]..
  13. PLASMA PROTEIN PHENOTYPING OF PROTHROMBOTIC MICE
    Alvin Schmaier; Fiscal Year: 2003
    ..These studies could serve as a basis for the development of a global assay(s) to predict the prothrombotic state in man. (End of Abstract.) ..
  14. Human Kallikrein 4 (hK4): A New Prostatic Biomarker?
    Eleftherios Diamandis; Fiscal Year: 2003
    ..If successful, our research will contribute to the development of new prostatic biomarkers and possibly, to better diagnosis which may lead to better clinical outcomes and reduced healthcare costs. ..
  15. Axima-CFR MALDI TOF Mass Spectrometer
    EDWARD FEENER; Fiscal Year: 2003
    ....
  16. Regulation of angiotensin-induced PAI-1 expression
    EDWARD FEENER; Fiscal Year: 2006
    ..51B6.g7g7 mice). The long-term objective is to identify novel targets and approaches to control the blood pressure independent effects of Ang II on PAI-1 expression. ..
  17. Long-term prediction of prostate cancer death from kallikreins measured in blood
    Hans Lilja; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  18. Novel Pathways of Polyphosphate Synthesis
    Arthur Kornberg; Fiscal Year: 2005
    ..research will focus on three areas: 1) Novel pathways of poly P synthesis in addition to that of poly P kinase (PPK 1) already characterized in Escherichia coli and other bacteria...
  19. Biochemical Mechanisms of Polyphosphate in Metabolism
    Arthur Kornberg; Fiscal Year: 2005
    ..The widespread conservation of the enzyme, poly P kinase (PPK), responsible for poiy P synthesis in bacteria, including many of the major pathogens, has led us to knockout ppk ..
  20. Protocadherin-PC and Prostate Cancer
    Ralph Buttyan; Fiscal Year: 2009
    ....
  21. ANDROGEN RECEPTOR AND PROSTATE CANCER RISK IN CHINESE
    Gerhard Coetzee; Fiscal Year: 2003
    ..abstract_text> ..
  22. MOLECULAR MODELING OF DIAGNOSIS AND PROGNOSIS IN HNSCC
    Maria Worsham; Fiscal Year: 2009
    ..abstract_text> ..
  23. A New Biomarker for Ovarian Cancer Detection
    Eleftherios Diamandis; Fiscal Year: 2003
    ..In this grant proposal, we describe further studies, which will examine in greater detail, the ability of a test for the amount of this protein in blood to correctly diagnose the presence of ovarian cancer. ..
  24. BENIGN BREAST DISEASE--MOLECULAR DIFFERENTIATION OF RISK
    Maria Worsham; Fiscal Year: 2001
    ....