KLK5

Summary

Gene Symbol: KLK5
Description: kallikrein related peptidase 5
Alias: KLK-L2, KLKL2, SCTE, kallikrein-5, kallikrein-like protein 2, stratum corneum tryptic enzyme
Species: human

Top Publications

  1. pmc Human kallikrein gene 5 (KLK5) expression is an indicator of poor prognosis in ovarian cancer
    H Kim
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Ave, Toronto, M5G 1X5, Canada
    Br J Cancer 84:643-50. 2001
  2. ncbi Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity
    Pascal Descargues
    INSERM U563, Paul Sabatier University, Place du Dr Baylac, 31059 Toulouse, Cedex 3, France
    Nat Genet 37:56-65. 2005
  3. ncbi Human tissue kallikreins: the cancer biomarker family
    Miltiadis Paliouras
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
    Cancer Lett 249:61-79. 2007
  4. pmc Kallikrein-5 promotes cleavage of desmoglein-1 and loss of cell-cell cohesion in oral squamous cell carcinoma
    Rong Jiang
    Department of Pathology and Anatomical Science, University of Missouri School of Medicine, Columbia, Missouri 65212, USA
    J Biol Chem 286:9127-35. 2011
  5. doi Activation of hepatocyte growth factor activator zymogen (pro-HGFA) by human kallikrein 1-related peptidases
    Shoichiro Mukai
    Section of Oncopathology and Regenerative Biology, Department of Pathology, Faculty of Medicine, University of Miyazaki, Japan
    FEBS J 275:1003-17. 2008
  6. ncbi Purification, molecular cloning, and expression of a human stratum corneum trypsin-like serine protease with possible function in desquamation
    M Brattsand
    Department of Public Health, Umea University, SE 901 85 Umea, Sweden
    J Biol Chem 274:30033-40. 1999
  7. ncbi Degradation of corneodesmosome proteins by two serine proteases of the kallikrein family, SCTE/KLK5/hK5 and SCCE/KLK7/hK7
    Cecile Caubet
    UMR5165 Epidermis Differentiation and Rheumatoid Autoimmunity, CNRS P Sabatier University Institut Fédératif de Recherche 30 and INSERM CNRS Université P Sabatier Centre Hospitalier Universitaire, Toulouse, France
    J Invest Dermatol 122:1235-44. 2004
  8. ncbi A proteolytic cascade of kallikreins in the stratum corneum
    Maria Brattsand
    Department of Public Health and Clinical Medicine, Dermatology and Venereology, Umea University, Umea, Sweden
    J Invest Dermatol 124:198-203. 2005
  9. ncbi Biochemical and enzymatic characterization of human kallikrein 5 (hK5), a novel serine protease potentially involved in cancer progression
    Iacovos P Michael
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    J Biol Chem 280:14628-35. 2005
  10. ncbi Human tissue kallikrein 5 is a member of a proteolytic cascade pathway involved in seminal clot liquefaction and potentially in prostate cancer progression
    Iacovos P Michael
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    J Biol Chem 281:12743-50. 2006

Research Grants

  1. Richard L Gallo; Fiscal Year: 2015
  2. CANDIDATE NEW BIOMARKER FOR BREAST CANCER DIAGNOSIS
    Eleftherios Diamandis; Fiscal Year: 2001
  3. Human Kallikrein 4 (hK4): A New Prostatic Biomarker?
    Eleftherios Diamandis; Fiscal Year: 2003
  4. A New Biomarker for Ovarian Cancer Detection
    Eleftherios Diamandis; Fiscal Year: 2003
  5. Potential Role of pp72syk in Pancreatic Adenocarcinoma
    STEVEN SILLETTI; Fiscal Year: 2005
  6. KALLIKREINS AS DIAGNOSTIC MARKERS OF OVARIAN CARCINOMA
    Eleftherios Diamandis; Fiscal Year: 2008
  7. Traget-Driven Identification of Diagnostic Patterns in Pancreatic Adenocarcinoma
    STEVEN SILLETTI; Fiscal Year: 2008

Scientific Experts

Detail Information

Publications129 found, 100 shown here

  1. pmc Human kallikrein gene 5 (KLK5) expression is an indicator of poor prognosis in ovarian cancer
    H Kim
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Ave, Toronto, M5G 1X5, Canada
    Br J Cancer 84:643-50. 2001
    Kallikrein gene 5 (KLK5, also known as KLK-L2), located on chromosome 19q13.4, is one of the newly identified members of the kallikrein gene family, which is a subgroup of the serine protease enzyme family...
  2. ncbi Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity
    Pascal Descargues
    INSERM U563, Paul Sabatier University, Place du Dr Baylac, 31059 Toulouse, Cedex 3, France
    Nat Genet 37:56-65. 2005
    ..abnormal desmosome cleavage in the upper granular layer through degradation of desmoglein 1 due to stratum corneum tryptic enzyme and stratum corneum chymotryptic enzyme-like hyperactivity...
  3. ncbi Human tissue kallikreins: the cancer biomarker family
    Miltiadis Paliouras
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
    Cancer Lett 249:61-79. 2007
    ..Along with these kallikreins, several others have been implicated in the other cancers. For example, KLK5, 6, 7, 10, 11, and 14 are emerging biomarkers for ovarian cancer...
  4. pmc Kallikrein-5 promotes cleavage of desmoglein-1 and loss of cell-cell cohesion in oral squamous cell carcinoma
    Rong Jiang
    Department of Pathology and Anatomical Science, University of Missouri School of Medicine, Columbia, Missouri 65212, USA
    J Biol Chem 286:9127-35. 2011
    ..Current studies focus on understanding the potential role of KLK5 in OSCC progression...
  5. doi Activation of hepatocyte growth factor activator zymogen (pro-HGFA) by human kallikrein 1-related peptidases
    Shoichiro Mukai
    Section of Oncopathology and Regenerative Biology, Department of Pathology, Faculty of Medicine, University of Miyazaki, Japan
    FEBS J 275:1003-17. 2008
    ..Among the KLKs examined (KLK2, KLK3, KLK4 and KLK5), we identified KLK4 and KLK5 as novel activators of pro-HGFA...
  6. ncbi Purification, molecular cloning, and expression of a human stratum corneum trypsin-like serine protease with possible function in desquamation
    M Brattsand
    Department of Public Health, Umea University, SE 901 85 Umea, Sweden
    J Biol Chem 274:30033-40. 1999
    ..The function of this new protease, tentatively named stratum corneum tryptic enzyme, may be related to stratum corneum turnover and desquamation in the epidermis.
  7. ncbi Degradation of corneodesmosome proteins by two serine proteases of the kallikrein family, SCTE/KLK5/hK5 and SCCE/KLK7/hK7
    Cecile Caubet
    UMR5165 Epidermis Differentiation and Rheumatoid Autoimmunity, CNRS P Sabatier University Institut Fédératif de Recherche 30 and INSERM CNRS Université P Sabatier Centre Hospitalier Universitaire, Toulouse, France
    J Invest Dermatol 122:1235-44. 2004
    ..have been implicated in this process: the stratum corneum chymotryptic enzyme (SCCE/KLK7/hK7) and the stratum corneum tryptic enzyme (SCTE/KLK5/hK5)...
  8. ncbi A proteolytic cascade of kallikreins in the stratum corneum
    Maria Brattsand
    Department of Public Health and Clinical Medicine, Dermatology and Venereology, Umea University, Umea, Sweden
    J Invest Dermatol 124:198-203. 2005
    ..We conclude that the enzymes studied may be part of a protease cascade in the stratum corneum, and that the observed pH effects may have physiological relevance...
  9. ncbi Biochemical and enzymatic characterization of human kallikrein 5 (hK5), a novel serine protease potentially involved in cancer progression
    Iacovos P Michael
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    J Biol Chem 280:14628-35. 2005
    Human kallikrein 5 (KLK5) is a member of the human kallikrein gene family of serine proteases. Preliminary results indicate that the protein, hK5, may be a potential serological marker for breast and ovarian cancer...
  10. ncbi Human tissue kallikrein 5 is a member of a proteolytic cascade pathway involved in seminal clot liquefaction and potentially in prostate cancer progression
    Iacovos P Michael
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    J Biol Chem 281:12743-50. 2006
    ..Several lines of evidence suggest that hKs participate in proteolytic cascade pathways. Human kallikrein 5 (hK5) has trypsin-like activity, is able to self-activate, and is co-expressed in various tissues with other ..
  11. ncbi Corneodesmosomal cadherins are preferential targets of stratum corneum trypsin- and chymotrypsin-like hyperactivity in Netherton syndrome
    Pascal Descargues
    Department of Functional Genetics of Epithelial Diseases, INSERM U563, Toulouse Cedex, France
    J Invest Dermatol 126:1622-32. 2006
    ..These defects were associated with premature degradation of corneodesmosomes. Stratum corneum tryptic enzyme (SCTE)-like and stratum corneum chymotryptic enzyme (SCCE)-like activities were increased, suggesting ..
  12. ncbi Proteinase-activated receptors, targets for kallikrein signaling
    Katerina Oikonomopoulou
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5G 1L5, Canada
    J Biol Chem 281:32095-112. 2006
    ..Our data indicate that in physiological settings, hKs may represent important endogenous regulators of the PARs and that different hKs can have differential actions on PAR(1), PAR(2), and PAR(4)...
  13. ncbi Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin
    Kenshi Yamasaki
    Division of Dermatology, University of California, San Diego, and VA San Diego Health Care System, San Diego, California, USA
    FASEB J 20:2068-80. 2006
    ..Through the use of selective inhibitors, SELDI-TOF-MS, Western blot, and siRNA, the serine proteases stratum corneum tryptic enzyme (SCTE, kallikrein 5) and stratum corneum chymotryptic protease (SCCE, kallikrein 7) were shown to ..
  14. ncbi Activation of proteinase-activated receptor-2 by human kallikrein-related peptidases
    Kristina Stefansson
    Department of Public Health and Clinical Medicine, Dermatology and Venereology, Umea University, Umea, Sweden
    J Invest Dermatol 128:18-25. 2008
    ..We found that KLK5 and KLK14, but neither KLK7 nor KLK8, induced PAR2 signalling...
  15. doi Parallel underexpression of kallikrein 5 and kallikrein 7 mRNA in breast malignancies
    Xiaoqing Li
    Department of Biochemistry and Molecular Biology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, 300060 China
    Cancer Sci 100:601-7. 2009
    ..However, the expression levels of KLK5 and KLK7 in benign breast tissues and metastases, and the relationship between KLK5 and KLK7, have not been ..
  16. doi Human kallikrein 5: an interesting novel biomarker in ovarian cancer patients that elicits humoral response
    Elisabetta Bandiera
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Laboratorio di Medicina Molecolare Angelo Nocivelli, University of Brescia, Piazzale Spedali Civili 1, Brescia, Italy
    Int J Gynecol Cancer 19:1015-21. 2009
    ..A recent study demonstrated that kallikrein-related peptidase 5 (KLK5) concentration is elevated in serum of patients with ovarian carcinoma...
  17. doi Circulating biomarker tissue kallikrein-related peptidase KLK5 impacts ovarian cancer patients' survival
    J Dorn
    Department of Obstetrics and Gynecology, Technical University of Munich, Munich, Germany
    Ann Oncol 22:1783-90. 2011
    ..Kallikrein-related peptidases, including KLK5, have been reported to play an important role in the course of the disease.
  18. pmc Kallikreins 5, 6 and 10 differentially alter pathophysiology and overall survival in an ovarian cancer xenograft model
    David Pépin
    Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada
    PLoS ONE 6:e26075. 2011
    ..In ovarian cancer, 12 KLKs are upregulated, and of those KLK5, 6 and 10 have been the focus of investigations into new diagnostic and prognostic biomarkers...
  19. pmc Kallikrein-related peptidase 5 functions in proteolytic processing of profilaggrin in cultured human keratinocytes
    Jun Ichi Sakabe
    Department of Dermatology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Higashi ku, Hamamatsu 431 3192, Japan
    J Biol Chem 288:17179-89. 2013
    ..Kallikrein-related peptidase 5 (KLK5) is a major serine protease found in the skin, which is secreted from lamellar granules following its expression in ..
  20. ncbi Skin barrier disruption by sodium lauryl sulfate-exposure alters the expressions of involucrin, transglutaminase 1, profilaggrin, and kallikreins during the repair phase in human skin in vivo
    Hans Torma
    Dermatology and Venereology Section, Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    J Invest Dermatol 128:1212-9. 2008
    ..Changes in protein expression of KLK-5 were also found. In conclusion, SLS-induced skin barrier defects induce altered mRNA expression of keratinocyte differentiation markers and enzymes degrading corneodesmosomes...
  21. pmc LEKTI fragments specifically inhibit KLK5, KLK7, and KLK14 and control desquamation through a pH-dependent interaction
    Celine Deraison
    Institut National de la Sante et de la Recherche Medicale, U563, Toulouse, F 31300 France
    Mol Biol Cell 18:3607-19. 2007
    ..The strongest inhibition was observed with D8-D11, toward KLK5. Kinetics analysis revealed that this interaction is rapid and irreversible, reflecting an extremely tight binding ..
  22. pmc Premature terminal differentiation and a reduction in specific proteases associated with loss of ABCA12 in Harlequin ichthyosis
    Anna C Thomas
    Queen Mary University of London, Barts and the London School of Medicine and Dentistry, London, E1 2AT, UK
    Am J Pathol 174:970-8. 2009
    ..Expression of the proteases kallikrein 5 and cathepsin D was dramatically reduced in both HI epidermis and the OTCC model...
  23. doi Trapping efficiencies of cultivated and natural riparian vegetation of northern Laos
    Olga Vigiak
    International Water Management Institute, IWMI Laos, Vientiane, Lao PDR
    J Environ Qual 37:889-97. 2008
    ..Water trapping efficiency (WTE) and sediment concentration trapping efficiency (SCTE) were calculated on an event basis; means and 95% confidence intervals (CIs) were estimated with a bootstrapping ..
  24. doi Alternative splicing variant of kallikrein-related peptidase 8 as an independent predictor of unfavorable prognosis in lung cancer
    Chris Planque
    Universite Francois Rabelais de Tours, Tours, France
    Clin Chem 56:987-97. 2010
    ..We undertook this study to evaluate the usefulness of mRNA isoforms encoded by the KLK8 (kallikrein-related peptidase 8) gene as prognostic markers for lung cancer...
  25. doi A heterozygous null mutation combined with the G1258A polymorphism of SPINK5 causes impaired LEKTI function and abnormal expression of skin barrier proteins
    W L Di
    Immunobiology Unit, UCL Institute of Child Health, 30 Guilford Street, London, UK
    Br J Dermatol 161:404-12. 2009
    ..G1258A polymorphism in SPINK5 may be associated with atopic dermatitis, which shares several clinical features with NS...
  26. ncbi Human kallikrein gene 5 (KLK5) expression by quantitative PCR: an independent indicator of poor prognosis in breast cancer
    George M Yousef
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Ave, Toronto, Ontario, M5G 1X5 Canada
    Clin Chem 48:1241-50. 2002
    b>KLK5 is a newly discovered human kallikrein gene...
  27. ncbi In silico identification and Bayesian phylogenetic analysis of multiple new mammalian kallikrein gene families
    Marc B Elliott
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada M5G 1L5
    Genomics 88:591-9. 2006
    ..from the pig (Sus scrofa) genome, which lacked homologues to KLK2 and KLK3, and 11 genes, orthologous to human KLK5 through KLK15, were found in the opossum (Monodelphis domestica) genome...
  28. ncbi Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea
    Kenshi Yamasaki
    Division of Dermatology, University of California, San Diego, and VA San Diego Health Care System, 3350 La Jolla Village Drive, San Diego, California 92161, USA
    Nat Med 13:975-80. 2007
    ..peptides are a result of a post-translational processing abnormality associated with an increase in stratum corneum tryptic enzyme (SCTE) in the epidermis...
  29. doi Glutathione peroxidase 2 and aquaporin 8 as new markers for colonic inflammation in experimental colitis and inflammatory bowel diseases: an important role for H2O2?
    Anje A te Velde
    Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Eur J Gastroenterol Hepatol 20:555-60. 2008
    ..We looked for overlapping gene expression profiles in three different mouse models of experimental colitis and analysed whether these overlapping genes are of help to find new genes that could be used as general markers in human IBD...
  30. doi High-throughput screening identifies cardiac glycosides as potent inhibitors of human tissue kallikrein expression: implications for cancer therapies
    Ioannis Prassas
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Clin Cancer Res 14:5778-84. 2008
    ..Therefore, the identification of compounds that would modulate expression of KLKs might be of considerable therapeutic value...
  31. doi Expression of bleomycin hydrolase in keratinization disorders
    Yayoi Kamata
    Department of Regulation Biochemistry, Graduate School of Medical Sciences, Kitasato University, Minami Ku, Sagamihara, Kanagawa, Japan
    Arch Dermatol Res 304:31-8. 2012
    ..On the other hand, cells positive for serine proteases kallikrein 5 and 7 were increased in parakeratotic and inflammatory skin diseases, such as psoriasis...
  32. doi Non-combinatorial library screening reveals subsite cooperativity and identifies new high-efficiency substrates for kallikrein-related peptidase 14
    Simon J de Veer
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
    Biol Chem 393:331-41. 2012
    ..structural rationale for the divergent subsite preferences evident between KLK14 and closely related KLKs, KLK4 and KLK5. Collectively, these findings highlight the importance of binding site cooperativity in protease substrate ..
  33. doi Influence of niacinamide containing formulations on the molecular and biophysical properties of the stratum corneum
    D Mohammed
    Department of Pharmaceutics, UCL School of Pharmacy, 29 39 Brunswick Square, London WC1N 1AX, United Kingdom
    Int J Pharm 441:192-201. 2013
    ..In addition, activity of the desquamatory kallikrein (KLK) protease enzymes KLK5 and KLK7, and tryptase and plasmin (implicated in inflammatory process) were measured using a fluorogenic probe ..
  34. pmc Transgenic kallikrein 5 mice reproduce major cutaneous and systemic hallmarks of Netherton syndrome
    Laetitia Furio
    Université Paris Descartes Sorbonne Paris Cité, 75006 Paris, France
    J Exp Med 211:499-513. 2014
    ..KLK) 5, KLK7, and elastase-2 (ELA2), which are suggested to be part of a proteolytic cascade initiated by KLK5. To address the role of KLK5 in NS, we have generated a new transgenic murine model expressing human KLK5 in the ..
  35. doi Toward the first class of suicide inhibitors of kallikreins involved in skin diseases
    Xiao Tan
    Sorbonne Universités, UPMC University Paris 06, UMR 8256, B2A, Biological Adaptation and Ageing, Integrated Cellular Ageing and Inflammation, Molecular and Functional Enzymology, Institut de Biologie Paris Seine, 7 quai St Bernard, F 75005 Paris, France
    J Med Chem 58:598-612. 2015
    ..In situ zymography investigations on skin sections from human kallikrein 5 transgenic mouse revealed significant reduction of the global proteolytic activity by several compounds.
  36. doi Effect of different alcohols on stratum corneum kallikrein 5 and phospholipase A2 together with epidermal keratinocytes and skin irritation
    T Cartner
    GOJO Industries, Inc, PO Box 991, Akron, OH, 44309 0991, USA
    Int J Cosmet Sci . 2016
    ..The aim of this exploratory study was to investigate the effect of ethanol, isopropanol and n-propanol on stratum corneum (SC) enzymes and keratinocytes in vitro together with their effects on skin condition and function...
  37. ncbi Aberrant human tissue kallikrein levels in the stratum corneum and serum of patients with psoriasis: dependence on phenotype, severity and therapy
    N Komatsu
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    Br J Dermatol 156:875-83. 2007
    ..Multiple KLKs have been quantitatively identified in normal stratum corneum (SC) and sweat as candidate desquamation-related proteases...
  38. pmc Kallikrein 5 induces atopic dermatitis-like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndrome
    Anaïs Briot
    Institut National de la Sante et de la Recherche Medicale, U563, Toulouse F 31300, France
    J Exp Med 206:1135-47. 2009
    ..Collectively, these data establish that uncontrolled KLK5 activity in NS epidermis can trigger atopic dermatitis (AD)-like lesions, independently of the environment and the ..
  39. doi Increased mass levels of certain serine proteases in the stratum corneum in acute eczematous atopic skin
    R Voegeli
    DSM Nutritional Products Ltd, Basel, Switzerland
    Int J Cosmet Sci 33:560-5. 2011
    ..The mass levels of KLK5 and KLK14 together with urokinase were not elevated in the SC in atopic skin...
  40. ncbi Evaluation of kallikrein-related peptidase 5 expression and its significance for breast cancer patients: association with kallikrein-related peptidase 7 expression
    Maroulio Talieri
    Department of Cellular Physiology, G Papanicolaou Research Center of Oncology, Saint Savvas Hospital, 171 Alexandras Avenue, Athens 11522, Greece
    Anticancer Res 31:3093-100. 2011
    Kallikrein-related peptidases (KLKs) have been proposed as potential cancer biomarkers. Contradictions in literature led us to clarify the role of KLK5 as a breast cancer predictor, as well as its association with KLK7 expression.
  41. doi Transcriptional gene silencing of kallikrein 5 and kallikrein 7 using siRNA prevents epithelial cell detachment induced by alkaline shock in an in vitro model of eczema
    Stephen Britland
    School of Pharmacy and Centre for Skin Sciences, University of Bradford, Bradford BD71DP, UK
    Biotechnol Prog 28:485-9. 2012
    ..At least two serine proteases, stratum corneum chymotryptic enzyme (kallikrein 7 [KLK7]) and stratum corneum tryptic enzyme (kallikrien 5 [KLK5]), have increased activity levels in eczematous lesions and both have been ..
  42. pmc Doxycycline indirectly inhibits proteolytic activation of tryptic kallikrein-related peptidases and activation of cathelicidin
    Kimberly N Kanada
    Division of Dermatology, Department of Medicine, University of California, San Diego, San Diego, California 92093, USA
    J Invest Dermatol 132:1435-42. 2012
    The increased abundance and activity of cathelicidin and kallikrein 5 (KLK5), a predominant trypsin-like serine protease (TLSP) in the stratum corneum, have been implicated in the pathogenesis of rosacea, a disorder treated by the use of ..
  43. doi Fructose 1, 6-diphosphate regulates desmosomal proteins and collagen fibres in human skin equivalents
    Hyun Choi
    Bioscience Research Institute, AmorePacific Corporation R and D Center, Yongin, Gyeonggi Do, Korea
    Exp Dermatol 22:847-9. 2013
    ..as desmoglein 1 (DSG1), desmocollin 1 (DSC1) and corneodesmosin (CDSN), and desquamation-related proteases, kallikrein 5 (KLK 5) and kallikrein 7 (KLK7) in normal human epidermal keratinocytes (NHEKs)...
  44. doi Subantimicrobial-dose doxycycline monohydrate in dermatology
    Uwe Wollina
    Department of Dermatology and Allergology, Academic Teaching Hospital Dresden Friedrichstadt, Friedrichstrasse 41, 01067, Dresden, Germany
    Wien Med Wochenschr 165:499-503. 2015
    Subantimicrobial doxycycline is an anti-inflammatory drug that decreases cathelicidin, kallikrein 5, reactive oxygen species, nitric oxide, and matrix metalloproteinases...
  45. doi Synthesis, antiproliferative activities, and computational evaluation of novel isocoumarin and 3,4-dihydroisocoumarin derivatives
    Keller G Guimarães
    Laboratório de Síntese Orgânica Labsinto, Departamento de Quimica, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270 901, Brazil
    Eur J Med Chem 111:103-13. 2016
    ..Furthermore, docking calculations were performed for the kallikrein 5 (KLK5) active site to predict the possible mechanism of action of this series of compounds...
  46. pmc KLK5 and KLK7 Ablation Fully Rescues Lethality of Netherton Syndrome-like Phenotype
    Petr Kaspárek
    Laboratory of Transgenic Models of Diseases, Division BIOCEV, Institute of Molecular Genetics of the ASCR, Vestec, Czech Republic
    PLoS Genet 13:e1006566. 2017
    ..b>KLK5 was proposed as a major protease in NS pathology, however its inactivation is not sufficient to rescue the lethal ..
  47. ncbi Human kallikrein 3 (prostate specific antigen) and human kallikrein 5 expression in salivary gland tumors
    M R Darling
    Division of Oral Pathology, Department of Pathology, University of Western Ontario, London, Ontario N6A 5C1, Canada
    Int J Biol Markers 21:201-5. 2006
    The human kallikrein 5 protein (hK5) is expressed in many normal tissues, most notably in skin, breast, salivary gland and esophagus. It has also been shown to be a potential biomarker for breast, ovarian and testicular cancer...
  48. pmc Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development
    Kristopher R Schwab
    Division of Developmental Biology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    BMC Biol 5:15. 2007
    ..To better understand the functions of Pygopus-mediated canonical Wnt signaling in kidney development, targeted mutations were made in the two mammalian orthologs, Pygo1 and Pygo2...
  49. ncbi Human tissue kallikrein expression in the stratum corneum and serum of atopic dermatitis patients
    Nahoko Komatsu
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada
    Exp Dermatol 16:513-9. 2007
    ..We report quantification by enzyme-linked immunosorbent assay (ELISA) of KLK5, KLK6, KLK7, KLK8, KLK10, KLK11, KLK13 and KLK14 in the SC and serum of atopic dermatitis (AD) patients by ELISA, ..
  50. ncbi Defining the extended substrate specificity of kallikrein 1-related peptidases
    Carla A Borgono
    Department of Laboratory Medicine and Pathobiology, University of Toronto and Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada
    Biol Chem 388:1215-25. 2007
    ..recognition motifs based on optimal subsite occupancy were as follows: VI-QSAV-QL-R for KLK4; YFWGPV-RK-NSFAM-R for KLK5; VY-R-LFM-R for KLK13; and YW-KRSAM-HNSPA-R for KLK14...
  51. doi Human tissue kallikreins as promiscuous modulators of homeostatic skin barrier functions
    Azza Eissa
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto M5G 1L5, ON, Canada
    Biol Chem 389:669-80. 2008
    ..Until recently, kallikrein proteolytic activity in the skin was exclusively attributed to KLK5 and KLK7...
  52. pmc Acute skin eruptions that are positive for herpes simplex virus DNA polymerase in patients with stem cell transplantation: a new manifestation within the erythema multiforme reactive dermatoses
    Joseph W Burnett
    Department of Dermatology, University of Maryland, 4401 Roland Ave, Baltimore, MD 21210, USA
    Arch Dermatol 144:902-7. 2008
    Patients with stem cell transplantation (SCT) develop erythematous eruptions (SCTE) that are often misdiagnosed and poorly treated. Latent herpes simplex virus (HSV) is likely to be reactivated by SCT-associated immunosuppression...
  53. pmc Prediction of ovarian cancer prognosis and response to chemotherapy by a serum-based multiparametric biomarker panel
    K Oikonomopoulou
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G1L5, Canada
    Br J Cancer 99:1103-13. 2008
    ..A multiparametric model (c(0) of CA125, KLK5, KLK7 and rc(1) of CA125) provided predictive accuracy with area under the ROC curve (AUC) of 0.82 (0...
  54. doi Long-term treatment with moisturizers affects the mRNA levels of genes involved in keratinocyte differentiation and desquamation
    Izabela Buraczewska
    Department of Medical Sciences, Dermatology and Venereology, University Hospital, 751 85 Uppsala, Sweden
    Arch Dermatol Res 301:175-81. 2009
    ..Treatment with one test moisturizer increased gene expression of involucrin, transglutaminase 1, kallikrein 5, and kallikrein 7, while the other moisturizer affected only expression of cyclin-dependent kinase inhibitor 1A...
  55. ncbi The protein therapy of kallikrein in cerebral ischemic reperfusion injury
    Yuping Tang
    Department of Neurology, Huashan Hospital, Fudan University, Number 12 Wulumuqi Mid Road, Shanghai, PR China
    Curr Med Chem 16:4502-10. 2009
    ..We constructed the Protein Transduction Domain-Kallikrein (PTD-Kallikrein), checked its function of penetration and biotoxicity, and observed its influence on neurons and ischemic brain tissues...
  56. doi Analyzing the protease web in skin: meprin metalloproteases are activated specifically by KLK4, 5 and 8 vice versa leading to processing of proKLK7 thereby triggering its activation
    Anke Ohler
    Institute of Zoology, Cell and Matrix Biology, Johannes Gutenberg University, Mainz, Germany
    Biol Chem 391:455-60. 2010
    ..Here, we identify human kallikrein-related peptidases (KLKs) 4, 5, and 8 to be specific activators of meprins. KLK5 is capable of activating both metalloproteases...
  57. pmc Sleep loss and cytokines levels in an experimental model of psoriasis
    Camila Hirotsu
    Departamento de Psicobiologia, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    PLoS ONE 7:e51183. 2012
    ..Thus, sleep loss should be considered a risk factor for the development of psoriasis...
  58. ncbi Prognostic value of quantitatively assessed KLK7 expression in ovarian cancer
    Lianna G Kyriakopoulou
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, M5G 1X5 Canada
    Clin Biochem 36:135-43. 2003
    ..of the kallikrein family are involved in various malignancies such as prostate (PSA, KLK2, KLK15), ovarian (KLK4, KLK5, KLK6, KLK8, KLK10), and breast cancer (KLK10, KLK13, KLK14)...
  59. ncbi Human tissue kallikreins and testicular cancer
    Liu Ying Luo
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada
    APMIS 111:225-32; discussion 232-3. 2003
    ..In testicular germ cell tumors, some tissue kallikrein genes, including KLK5, KLK10, KLK13 and KLK14, were found to be significantly down-regulated...
  60. pmc Cleavage activation of human-adapted influenza virus subtypes by kallikrein-related peptidases 5 and 12
    Brian S Hamilton
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 288:17399-407. 2013
    ..Each peptidase appears to have a preference for particular influenza subtypes, with kallikrein 5 cleaving the H1 and H3 subtypes most efficiently and kallikrein 12 cleaving the H1 and H2 subtypes most ..
  61. pmc Cathelicidin, kallikrein 5, and serine protease activity is inhibited during treatment of rosacea with azelaic acid 15% gel
    Alvin B Coda
    Division of Dermatology, Department of Medicine, University of California San Diego, San Diego, California
    J Am Acad Dermatol 69:570-7. 2013
    Excess cathelicidin and kallikrein 5 (KLK5) have been hypothesized to play a role in the pathophysiology of rosacea.
  62. pmc Kallikrein cascades in traumatic spinal cord injury: in vitro evidence for roles in axonopathy and neuron degeneration
    Maja Radulovic
    From the Neurobiology of Disease Program MR, JEB, IAS and Departments of Physical Medicine and Rehabilitation HY, NL, JW, RL, IAS and Neurology IAS, Mayo Medical and Graduate School, Rochester, Minnesota Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada EPD Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, Florida SIB, MB and Department of Surgery, Toronto Western Research Institute, Toronto, Ontario, Canada MGF
    J Neuropathol Exp Neurol 72:1072-89. 2013
    ..injury (SCI), we evaluated acute through chronic changes in the immunohistochemical appearance of 6 KLKs (KLK1, KLK5, KLK6, KLK7, KLK8, and KLK9) in postmortem human traumatic SCI cases, quantified their RNA expression levels in ..
  63. doi Common variation in Kallikrein genes KLK5, KLK6, KLK12, and KLK13 and risk of prostate cancer and tumor aggressiveness
    Felicity Lose
    Molecular Cancer Epidemiology Group, Genetics and Population Health Division, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Urol Oncol 31:635-43. 2013
    ..We sought to elucidate the role of common genetic variation in four of the Kallikrein genes, KLK5, KLK6, KLK12, and KLK13, in prostate cancer risk and tumor aggressiveness...
  64. doi The 420K LEKTI variant alters LEKTI proteolytic activation and results in protease deregulation: implications for atopic dermatitis
    Paola Fortugno
    Dermatology Unit, Bambino Gesu Children s Hospital IRCCS, Rome 00165, Italy
    Hum Mol Genet 21:4187-200. 2012
    ..zymographies, we show that the modification of the subtle balance in LEKTI inhibitory fragments leads to enhanced KLK5, KLK7 and elastase-2 (ELA-2) activities in 420KK epidermis...
  65. doi Combined expression of KLK4, KLK5, KLK6, and KLK7 by ovarian cancer cells leads to decreased adhesion and paclitaxel-induced chemoresistance
    Daniela Loessner
    Cancer Program, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, Queensland 4059, Australia
    Gynecol Oncol 127:569-78. 2012
    ..We have previously shown that four kallikrein-related (KLK) peptidases, KLK4, KLK5, KLK6 and KLK7 (KLK4-7), are implicated in peritoneal invasion and tumour growth, but underlying mechanisms were ..
  66. doi Significant alterations in the expression pattern of kallikrein-related peptidase genes KLK4, KLK5 and KLK14 after treatment of breast cancer cells with the chemotherapeutic agents epirubicin, docetaxel and methotrexate
    Georgia Papachristopoulou
    Department of Biochemistry and Molecular Biology, University of Athens, 15701, Panepistimiopolis, Athens, Greece
    Tumour Biol 34:369-78. 2013
    ..Recently, our group has depicted that KLK4, KLK5, and KLK14 are differentially expressed in breast carcinoma...
  67. pmc A water extract of Samchulkunbi-tang attenuates airway inflammation by inhibiting inos and MMP-9 activities in an ovalbumin-induced murine asthma model
    Mee Young Lee
    Basic Herbal Medicine Research Group, Korea Institute of Oriental Medicine, 483 Expo ro, Yusung Gu, Daejeon, 305 811, Republic of Korea
    BMC Complement Altern Med 12:257. 2012
    In this study, we investigated the effect of Samchulkunbi-tang water extract (SCTE) in an established mouse model of ovalbumin (OVA)-induced allergic asthma...
  68. ncbi Temporal and tissue-specific expression of kallikrein (Klk) genes and identification of a novel Klk messenger ribonucleic acid transcript during early development in the mouse
    C S Chan
    Centre for Molecular Biotechnology, School of Life Sciences, Queensland University of Technology, Brisbane, Queensland 4001, Australia
    Biol Reprod 61:621-8. 1999
    ..to elucidate the temporal and tissue-specific expression patterns of the mouse kallikreins Klk1, Klk3, Klk5, Klk9, and Klk21 during early development in the embryo, uterus, and decidua...
  69. ncbi Stratum corneum tryptic enzyme in normal epidermis: a missing link in the desquamation process?
    I E Ekholm
    Department of Public Health and Clinical Medicine, Dermatology and Venereology, Umea University, Sweden
    J Invest Dermatol 114:56-63. 2000
    ..It has also been suggested that other proteases, especially stratum corneum tryptic enzyme, may be involved. Stratum corneum tryptic enzyme has been purified and its cDNA has been cloned...
  70. ncbi Identification of novel human kallikrein-like genes on chromosome 19q13.3-q13.4
    G M Yousef
    Department of Pathology, Mount Sinai Hospital, Toronto, Ontario, Canada
    Anticancer Res 19:2843-52. 1999
    ..These new genes, like the already known kallikreins, may have utility for diagnosis, monitoring and therapeutics of various cancers including those of the breast, prostate and testis...
  71. ncbi The new human kallikrein gene family: implications in carcinogenesis
    E P Diamandis
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    Trends Endocrinol Metab 11:54-60. 2000
    ..This brief review summarizes recent developments and possible applications of the newly defined and expanded human kallikrein gene locus...
  72. ncbi Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region
    L Gan
    Chiroscience R and D Inc 1631 220th St SE Bothell, WA 98021, USA
    Gene 257:119-30. 2000
    ..The proteases, excluding the kallikrein genes, share approximately 40% of their sequences suggesting that the serine protease gene cluster on chromosome 19q13 arose from ancient gene duplications...
  73. ncbi Differential splicing of KLK5 and KLK7 in epithelial ovarian cancer produces novel variants with potential as cancer biomarkers
    Ying Dong
    The Center of Molecular Biotechnology, School of Life Sciences, Queensland University of Technology, Brisbane, Australia
    Clin Cancer Res 9:1710-20. 2003
    ..Two of these KLK genes (KLK5 and KLK7) and their proteins (hK5 and hK7) were first identified in the skin epidermis, where hK5 may be the ..
  74. ncbi Expression and localization of tissue kallikrein mRNAs in human epidermis and appendages
    Nahoko Komatsu
    Department of Dermatology, Graduate School of Medical Science, School of Medicine, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8641, Japan
    J Invest Dermatol 121:542-9. 2003
    ..Quantitative RT-PCR analysis showed abundant expression of KLK1 and KLK11 mRNA, moderate expression of KLK4, KLK5, KLK6, KLK7, and KLK13 mRNA, and low expression of KLK8 mRNA in normal human skin...
  75. pmc Kallikrein gene downregulation in breast cancer
    G M Yousef
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    Br J Cancer 90:167-72. 2004
    ..Our results indicate that at least four kallikrein genes (KLK5, 6, 8, 10) are downregulated in breast cancer...
  76. ncbi Immunofluorometric quantification of human kallikrein 5 expression in ovarian cancer cytosols and its association with unfavorable patient prognosis
    Eleftherios P Diamandis
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada
    Tumour Biol 24:299-309. 2003
    Human kallikrein 5 (hK5; encoded by the KLK5 gene) is a secreted serine protease expressed in hormonally regulated tissues, including the breast and ovary...
  77. ncbi LEKTI is localized in lamellar granules, separated from KLK5 and KLK7, and is secreted in the extracellular spaces of the superficial stratum granulosum
    Akemi Ishida-Yamamoto
    Department of Dermatology, Asahikawa Medical College, Midorigaoka Higashi 2 1 1 1, Asahikawa 078 8510, Japan
    J Invest Dermatol 124:360-6. 2005
    ..understand the functional role of LEKTI, we examined the localization of LEKTI together with kallikrein (KLK)7 and KLK5, possible targets of LEKTI, in the human epidermis, by confocal laser scanning microscopy and immunoelectron ..
  78. ncbi KLK5 and KLK7, two members of the human tissue kallikrein family, are differentially expressed in lung cancer
    Chris Planque
    INSERM, U618, Protéases et Vectorisation Pulmonaires, Universite Francois Rabelais, Tours 37032, France
    Biochem Biophys Res Commun 329:1260-6. 2005
    ..Using RT-PCR and Western blotting, we demonstrated the expression of both KLK5 and KLK7, and their respective proteins (hK5 and hK7) in tumoral and nontumoral lung tissues...
  79. ncbi Identification of murine uterine genes regulated in a ligand-dependent manner by the progesterone receptor
    Jae Wook Jeong
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Endocrinology 146:3490-505. 2005
    ..P 450 26a1 (Cyp26a1), alcohol dehydrogenase 5, and aldehyde dehydrogenase 1a1 (Aldh1a1); kallikrein genes, Klk5 and Klk6; and specific transcription factors, GATA-2 and Cited2 [cAMP-corticosterone-binding protein/p300-..
  80. ncbi Expression analysis and prognostic significance of human kallikrein 11 in prostate cancer
    Panagiota Stavropoulou
    Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, 157 01 Athens, Greece
    Clin Chim Acta 357:190-5. 2005
    ..KLK11 has two alternative splicing isoforms, known as the brain type and prostate type. Many members of the human kallikrein gene family are differentially expressed in cancer and a few have potential as diagnostic/prognostic markers...
  81. ncbi Kallikrein-related peptidase 14 may be a major contributor to trypsin-like proteolytic activity in human stratum corneum
    Kristina Stefansson
    Department of Public Health and Clinical Medicine, Dermatology and Venereology, Umea University, S 901 85 Umea, Sweden
    Biol Chem 387:761-8. 2006
    We have previously presented evidence that two human kallikrein-related peptidases, KLK5 (hK5, stratum corneum tryptic enzyme, SCTE) and KLK7 (hK7, stratum corneum chymotryptic enzyme, SCCE), which are abundant in the stratum corneum, may ..
  82. ncbi A potential role for multiple tissue kallikrein serine proteases in epidermal desquamation
    Carla A Borgono
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Ontario M5G 1X5, Canada
    J Biol Chem 282:3640-52. 2007
    ..Two members of the human tissue kallikrein (KLK) family of (chymo)tryptic-like serine proteases, KLK5 and KLK7, are implicated in desquamation by digestion of (corneo)desmosomes and inhibition by desquamation-related ..
  83. ncbi Characterization of mouse tissue kallikrein 5
    Sanath Rajapakse
    Laboratory of Molecular and Cellular Interactions, Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan
    Zoolog Sci 23:963-8. 2006
    ..Mouse tissue kallikrein 5 (Klk5) has long been thought to be one of these functional genes, but the gene product, mK5, has not been ..
  84. ncbi Association of KLK5 overexpression with invasiveness of urinary bladder carcinoma cells
    Yasuo Shinoda
    Department of Molecular Cytogenetics, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan
    Cancer Sci 98:1078-86. 2007
    ..Expression levels of KLK5, -6, -8 and -9 were significantly increased in three cell lines with copy number gains of these KLK genes...
  85. ncbi Distribution of 15 human kallikreins in tissues and biological fluids
    Julie L V Shaw
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    Clin Chem 53:1423-32. 2007
    ..We characterized the protein and mRNA abundance patterns of all 15 KLKs in multiple panels of human tissues and biological fluids...
  86. ncbi Proteomics analysis of conditioned media from three breast cancer cell lines: a mine for biomarkers and therapeutic targets
    Vathany Kulasingam
    Department of Laboratory Medicine and Pathobiology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario M5G 1X5, Canada
    Mol Cell Proteomics 6:1997-2011. 2007
    ..a protease inhibitor, identified in the conditioned media of BT474 and MDA-MB-468 and the three kallikreins (KLK5, KLK6, and KLK10) were validated using an immunoassay on various serum and biological samples...
  87. ncbi Association of kallikrein gene polymorphisms with intracranial aneurysms
    Shantel Weinsheimer
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, 3309 Gordon H Scott Hall of Basic Medical Sciences, 540 East Canfield Avenue, Detroit, MI 48201, USA
    Stroke 38:2670-6. 2007
    ..We investigated the association of single nucleotide polymorphisms (SNPs) in the kallikrein gene cluster with IA in the Finnish population...
  88. doi Tissue-specific promoter utilisation of the kallikrein-related peptidase genes, KLK5 and KLK7, and cellular localisation of the encoded proteins suggest roles in exocrine pancreatic function
    Ying Dong
    Hormone Dependent Cancer Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia
    Biol Chem 389:99-109. 2008
    ..for expression of KLK4 to KLK15 identified pancreas as a common expression site for the gene cluster spanning KLK5 to KLK13, as well as for KLK15 which is located adjacent to KLK1...
  89. doi A multiparametric serum kallikrein panel for diagnosis of non-small cell lung carcinoma
    Chris Planque
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Clin Cancer Res 14:1355-62. 2008
    ..Here, we examined the clinical value of 11 members of the tissue kallikrein family as potential biomarkers for lung cancer diagnosis...
  90. doi Kallikreins as microRNA targets: an in silico and experimental-based analysis
    Tsz fung F Chow
    Department of Laboratory Medicine, and the Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto M5B 1W8, Canada
    Biol Chem 389:731-8. 2008
    ..KLK10 is the most frequently targeted kallikrein, followed by KLK5 and KLK13. KLK1, KLK3, KLK8 and KLK12 do not have strongly predicted miRNA/KLK interactions...
  91. doi Structures and specificity of the human kallikrein-related peptidases KLK 4, 5, 6, and 7
    Mekdes Debela
    Max Planck Institut fur Biochemie, Proteinase Research Group, Am Klopferspitz 18, D 82152 Martinsried, Germany
    Biol Chem 389:623-32. 2008
    ..advances in the purification of 'new type' recombinant KLKs allowed solution of the crystal structures of KLK4, KLK5, KLK6, and KLK7...
  92. doi Molecular signatures associated with transformation and progression to breast cancer in the isogenic MCF10 model
    Dong Keun Rhee
    Department of Biology, College of Life Science and Biotechnology, Yonsei University, Seoul 120 749, Republic of Korea
    Genomics 92:419-28. 2008
    ..The data presented here may facilitate the identification and functional analyses of prognostic biomarkers for breast cancer...
  93. doi Role of tissue kallikrein-related peptidases in cervical mucus remodeling and host defense
    Julie L V Shaw
    Department of Pathology and Laboratory Medicine and Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto M5T 3L9, ON, Canada and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto M5G 1L5, ON, Canada
    Biol Chem 389:1513-22. 2008
    ..b>KLK5 can digest defensin-1alpha, suggesting it may aid in cervico-vaginal host defense...
  94. pmc Multiple kallikrein (KLK 5, 7, 8, and 10) expression in squamous cell carcinoma of the oral cavity
    Jason R Pettus
    Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, MO 65212, USA
    Histol Histopathol 24:197-207. 2009
    ..qPCR analysis revealed 2.8-, 5.3-, 4.0-, and 3.5-fold increases in gene expression for KLK5, 7, 8, and 10, respectively, in SCC25-uPAR+ versus SCC25-uPAR-KD...
  95. doi Dichotomous effect of ultraviolet B on the expression of corneodesmosomal enzymes in human epidermal keratinocytes
    Megumi Nin
    Department of Dermatology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    J Dermatol Sci 54:17-24. 2009
    The stratum corneum chymotryptic enzyme (SCCE) and the stratum corneum tryptic enzyme (SCTE) are serine proteases of the kallikrein family that are encoded by the KLK7 and KLK5 genes, respectively...
  96. pmc Identification of lympho-epithelial Kazal-type inhibitor 2 in human skin as a kallikrein-related peptidase 5-specific protease inhibitor
    Ulf Meyer-Hoffert
    Department of Dermatology, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    PLoS ONE 4:e4372. 2009
    ..Since many KLKs are expressed in human skin with KLK5 being considered as one of the most important KLKs in skin desquamation, we proposed that more inhibitors are ..
  97. doi SPINK9: a selective, skin-specific Kazal-type serine protease inhibitor
    Maria Brattsand
    Department of Dermatology and Venereology, Public Health and Clinical Medicine, Umea University, Umea, Sweden
    J Invest Dermatol 129:1656-65. 2009
    ..KLKs) 5, 7, 8, and 14, thrombin, trypsin, and chymotrypsin, inhibition with recombinant SPINK9 was seen only for KLK5 using low molecular weight substrates, with an apparent K(i) of 65 nM...
  98. doi Quantitative analysis of human kallikrein 5 (KLK5) expression in prostate needle biopsies: an independent cancer biomarker
    Dimitrios Korbakis
    Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, Athens, Greece
    Clin Chem 55:904-13. 2009
    b>Kallikrein 5 (KLK5), a recently cloned member of the kallikrein family, codes for the secreted protein KLK5. Active KLK5 protein has a trypsin activity, and the expression of KLK5 gene seems to be regulated by steroid hormones...
  99. pmc The use of kallikrein-related peptidases as adjuvant prognostic markers in colorectal cancer
    M Talieri
    Department of Cellular Physiology, G Papanicolaou Research Center of Oncology, Saint Savvas Hospital, Athens, Greece
    Br J Cancer 100:1659-65. 2009
    ..Nine KLKs (KLK5-8, KLK10, KLK11, KLK13-15) were measured using ELISA assays in cytosolic extracts of 122 colon cancer tissues and ..
  100. doi Impact of cytogenetic and genomic aberrations of the kallikrein locus in ovarian cancer
    Jane Bayani
    Department of Applied Molecular Oncology, Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, Ontario, M5G 2M9, Canada
    Mol Oncol 2:250-60. 2008
    ..In this initial study, we introduce the potential for long-range chromosomal effects and copy number as a mechanism for the previously reported aberrant expression of many KLK genes in ovarian cancers...
  101. doi Association between kallikrein-related peptidases (KLKs) and macroscopic indicators of semen analysis: their relation to sperm motility
    Nashmil Emami
    Department of Laboratory Medicine and Pathobiology, University of Toronto, ON, Canada
    Biol Chem 390:921-9. 2009
    ..In conclusion, the expression level of several seminal plasma KLKs correlates with liquefaction and viscosity indicators of semen quality and may aid in their differential diagnosis and etiology...

Research Grants7

  1. Richard L Gallo; Fiscal Year: 2015
    ..have shown that activation of cathelicidin antimicrobial peptides is dependent on serine proteases including Kallikrein 5 and 7...
  2. CANDIDATE NEW BIOMARKER FOR BREAST CANCER DIAGNOSIS
    Eleftherios Diamandis; Fiscal Year: 2001
    ..abstract_text> ..
  3. Human Kallikrein 4 (hK4): A New Prostatic Biomarker?
    Eleftherios Diamandis; Fiscal Year: 2003
    ..If successful, our research will contribute to the development of new prostatic biomarkers and possibly, to better diagnosis which may lead to better clinical outcomes and reduced healthcare costs. ..
  4. A New Biomarker for Ovarian Cancer Detection
    Eleftherios Diamandis; Fiscal Year: 2003
    ..In this grant proposal, we describe further studies, which will examine in greater detail, the ability of a test for the amount of this protein in blood to correctly diagnose the presence of ovarian cancer. ..
  5. Potential Role of pp72syk in Pancreatic Adenocarcinoma
    STEVEN SILLETTI; Fiscal Year: 2005
    ..These studies should validate syk as a player in the biology of pancreatic adenocarcinoma, and should provide the basis for further investigations into the role of this kinase in this devastating disease. ..
  6. KALLIKREINS AS DIAGNOSTIC MARKERS OF OVARIAN CARCINOMA
    Eleftherios Diamandis; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  7. Traget-Driven Identification of Diagnostic Patterns in Pancreatic Adenocarcinoma
    STEVEN SILLETTI; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..