KLF6

Summary

Gene Symbol: KLF6
Description: Kruppel like factor 6
Alias: BCD1, CBA1, COPEB, CPBP, GBF, PAC1, ST12, ZF9, Krueppel-like factor 6, B-cell-derived protein 1, GC-rich binding factor, GC-rich sites-binding factor GBF, Kruppel-like zinc finger protein Zf9, core promoter element-binding protein, proto-oncogene BCD1, protooncogene B-cell derived 1, suppression of tumorigenicity 12 (prostate), suppressor of tumorigenicity 12 protein, transcription factor Zf9
Species: human

Top Publications

  1. doi HIV-1 infects macrophages by exploiting an endocytic route dependent on dynamin, Rac1 and Pak1
    Gemma C Carter
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Virology 409:234-50. 2011
  2. doi KLF6/Sp1 initiates transcription of the tmsg-1 gene in human prostate carcinoma cells: an exon involved mechanism
    Miaozi Gong
    Department of Pathology, Peking University Health Science Center, Beijing 100191, China
    J Cell Biochem 113:329-39. 2012
  3. ncbi Isolation and initial characterization of GBF, a novel DNA-binding zinc finger protein that binds to the GC-rich binding sites of the HIV-1 promoter
    T Suzuki
    Departments of Developmental Biology and Cellular Biology, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo ku, Tokyo, 113 0032, Japan
    J Biochem 124:389-95. 1998
  4. ncbi KLF6, a candidate tumor suppressor gene mutated in prostate cancer
    G Narla
    Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, 1425 Madison Avenue, Room 1170F, Box 1123, New York, NY, 10029, USA
    Science 294:2563-6. 2001
  5. ncbi Transcriptional activation of the human inducible nitric-oxide synthase promoter by Kruppel-like factor 6
    Vishal G Warke
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
    J Biol Chem 278:14812-9. 2003
  6. ncbi Cyclin-dependent kinase inhibition by the KLF6 tumor suppressor protein through interaction with cyclin D1
    Sharon Benzeno
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Cancer Res 64:3885-91. 2004
  7. ncbi A new role for the Kruppel-like transcription factor KLF6 as an inhibitor of c-Jun proto-oncoprotein function
    Daniela A Slavin
    Centro de Investigaciones en Bioquímica Clínica e Inmunología CIBICI CONICET Departamento de Bioquímica Clínica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Cordoba, Argentina
    Oncogene 23:8196-205. 2004
  8. ncbi Frequent inactivation of the tumor suppressor Kruppel-like factor 6 (KLF6) in hepatocellular carcinoma
    Sigal Kremer-Tal
    Division of Liver Diseases, Mount Sinai School of Medicine, New York, NY 10029, USA
    Hepatology 40:1047-52. 2004
  9. ncbi Genomic organization and functional analysis of the gene encoding the Krüppel-like transcription factor KLF6
    Ricardo C Gehrau
    Centro de Investigaciones en Bioquimica Clinica e Inmunologia, Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Haya de la Torre y Medina Allende, Ciudad Universitaria, 5000 Cordoba, Argentina
    Biochim Biophys Acta 1730:137-46. 2005
  10. ncbi KLF6: mutational analysis and effect on cancer cell proliferation
    Dong Yin
    Division of Hematology and Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA 90048, USA
    Int J Oncol 30:65-72. 2007

Research Grants

  1. Valentina Sabino; Fiscal Year: 2016
  2. MARGARET ANN VIZZARD; Fiscal Year: 2016
  3. Bradford B Lowell; Fiscal Year: 2014
  4. James A Waschek; Fiscal Year: 2014
  5. REGULATION OF PEPTIDE EXPRESSION IN NEURONAL CELLS
    Victor May; Fiscal Year: 2005
  6. Kerry J Ressler; Fiscal Year: 2016
  7. Biomarkers for Posttraumatic Stress in Women Following a Campus Mass Shooting
    Holly K Orcutt; Fiscal Year: 2012
  8. MAVIS AMITY IRWIN; Fiscal Year: 2014
  9. PACAP signaling in stress and anxiety
    William A Carlezon; Fiscal Year: 2012
  10. William A Carlezon; Fiscal Year: 2016

Detail Information

Publications187 found, 100 shown here

  1. doi HIV-1 infects macrophages by exploiting an endocytic route dependent on dynamin, Rac1 and Pak1
    Gemma C Carter
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Virology 409:234-50. 2011
    ..Because of the limitations of a purely pharmacological study such as this, the final elucidation of this pathway awaits the development of reliable forward genetic approaches in authentic macrophages...
  2. doi KLF6/Sp1 initiates transcription of the tmsg-1 gene in human prostate carcinoma cells: an exon involved mechanism
    Miaozi Gong
    Department of Pathology, Peking University Health Science Center, Beijing 100191, China
    J Cell Biochem 113:329-39. 2012
    ..Further analysis showed that transcription factors KLF6 and Sp1 are able to interact with each other and bind to their elements in this region...
  3. ncbi Isolation and initial characterization of GBF, a novel DNA-binding zinc finger protein that binds to the GC-rich binding sites of the HIV-1 promoter
    T Suzuki
    Departments of Developmental Biology and Cellular Biology, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo ku, Tokyo, 113 0032, Japan
    J Biochem 124:389-95. 1998
    ..A cDNA encoding a novel zinc finger protein named GBF, GC-rich sites binding factor, was isolated from a human peripheral blood leukocyte library...
  4. ncbi KLF6, a candidate tumor suppressor gene mutated in prostate cancer
    G Narla
    Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, 1425 Madison Avenue, Room 1170F, Box 1123, New York, NY, 10029, USA
    Science 294:2563-6. 2001
    Kruppel-like factor 6 (KLF6) is a zinc finger transcription factor of unknown function. Here, we show that the KLF6 gene is mutated in a subset of human prostate cancer...
  5. ncbi Transcriptional activation of the human inducible nitric-oxide synthase promoter by Kruppel-like factor 6
    Vishal G Warke
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
    J Biol Chem 278:14812-9. 2003
    ..have explored the transcriptional regulation of inducible nitric-oxide synthase (iNOS) by Krüppel-like factor 6 (KLF6), an Sp1-like zinc finger transcription factor...
  6. ncbi Cyclin-dependent kinase inhibition by the KLF6 tumor suppressor protein through interaction with cyclin D1
    Sharon Benzeno
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Cancer Res 64:3885-91. 2004
    Kruppel-like factor 6 (KLF6) is a tumor suppressor gene inactivated in prostate and colon cancers, as well as in astrocytic gliomas...
  7. ncbi A new role for the Kruppel-like transcription factor KLF6 as an inhibitor of c-Jun proto-oncoprotein function
    Daniela A Slavin
    Centro de Investigaciones en Bioquímica Clínica e Inmunología CIBICI CONICET Departamento de Bioquímica Clínica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Cordoba, Argentina
    Oncogene 23:8196-205. 2004
    ..Here, we demonstrate that KLF6 behaves as a functional antagonist of the c-Jun proto-oncoprotein...
  8. ncbi Frequent inactivation of the tumor suppressor Kruppel-like factor 6 (KLF6) in hepatocellular carcinoma
    Sigal Kremer-Tal
    Division of Liver Diseases, Mount Sinai School of Medicine, New York, NY 10029, USA
    Hepatology 40:1047-52. 2004
    ..Kruppel-like factor 6 (KLF6) is a ubiquitously expressed zinc finger transcription factor that is deregulated in multiple cancers through loss ..
  9. ncbi Genomic organization and functional analysis of the gene encoding the Krüppel-like transcription factor KLF6
    Ricardo C Gehrau
    Centro de Investigaciones en Bioquimica Clinica e Inmunologia, Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Haya de la Torre y Medina Allende, Ciudad Universitaria, 5000 Cordoba, Argentina
    Biochim Biophys Acta 1730:137-46. 2005
    The Krüppel-like transcription Factor 6 (KLF6) is regulated during cell proliferation and differentiation events like mammalian development and tissue regeneration, while its aberrant expression is associated with tumor formation...
  10. ncbi KLF6: mutational analysis and effect on cancer cell proliferation
    Dong Yin
    Division of Hematology and Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA 90048, USA
    Int J Oncol 30:65-72. 2007
    Kruppel-like factor 6 (KLF6/Zf9/CPBP), a member of the Kruppel-like family of zinc finger transcription factors, has recently been suggested to be a mutated tumor suppressor in selected human cancers...
  11. ncbi KLF6 transcription factor protects hepatocellular carcinoma-derived cells from apoptosis
    E Sirach
    INSERM U858, I2MR, Toulouse, France
    Cell Death Differ 14:1202-10. 2007
    ..Kruppel-like factor (KLF) family members, such as KLF6, are involved in cell proliferation and differentiation...
  12. doi Insulin-like growth factor-i regulates Kruppel-like factor-6 gene expression in a p53-dependent manner
    Itay Bentov
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Endocrinology 149:1890-7. 2008
    ..Krüppel-like factor-6 (KLF6) is a zinc finger tumor suppressor inactivated in prostate and other types of cancer...
  13. pmc Role of Kruppel-like factor 6 in transforming growth factor-beta1-induced epithelial-mesenchymal transition of proximal tubule cells
    John Holian
    Kolling Institute, Department of Medicine, Royal North Shore Hospital, Sydney
    Am J Physiol Renal Physiol 295:F1388-96. 2008
    Krüppel-like factor 6 (KLF6) is a DNA-binding protein containing a triple zinc-fingered motif and plays a key role in the regulation of cell proliferation, differentiation, and development...
  14. pmc KLF6-SV1 is a novel antiapoptotic protein that targets the BH3-only protein NOXA for degradation and whose inhibition extends survival in an ovarian cancer model
    Analisa Difeo
    Departments of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, USA
    Cancer Res 69:4733-41. 2009
    ..Here, we show that KLF6-SV1, whose overexpression is associated with poor survival in several different cancers and is an alternatively ..
  15. pmc Tumor suppressor activity of KLF6 mediated by downregulation of the PTTG1 oncogene
    Ursula E Lee
    Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    FEBS Lett 584:1006-10. 2010
    The tumor suppressor Kruppel-like factor 6 (KLF6) is frequently inactivated in hepatocellular carcinoma (HCC)...
  16. pmc Nuclear expression of KLF6 tumor suppressor factor is highly associated with overexpression of ERBB2 oncoprotein in ductal breast carcinomas
    Ricardo C Gehrau
    Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Centro de Investigaciones en Bioquímica Clínica e Inmunología CIBICI CONICET, Cordoba, Argentina
    PLoS ONE 5:e8929. 2010
    Krüppel-like factor 6 (KLF6) is an evolutionarily conserved and ubiquitously expressed protein that belongs to the mammalian Sp1/KLF family of transcriptional regulators...
  17. pmc Nucleo-cytoplasmic localization domains regulate Krüppel-like factor 6 (KLF6) protein stability and tumor suppressor function
    Estefania Rodriguez
    Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS ONE 5:. 2010
    The tumor suppressor KLF6 and its oncogenic cytoplasmic splice variant KLF6-SV1 represent a paradigm in cancer biology in that their antagonistic cancer functions are encoded within the same gene...
  18. ncbi A novel human zinc finger protein that interacts with the core promoter element of a TATA box-less gene
    N P Koritschoner
    Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Cordoba, Argentina
    J Biol Chem 272:9573-80. 1997
    ..The cDNA encoded a predicted protein of 290 amino acids, designated core promoter-binding protein (CPBP), which has three zinc fingers (type Cys2-His2) at the end of its C-terminal domain, a serine/threonine-rich ..
  19. pmc Zf9, a Kruppel-like transcription factor up-regulated in vivo during early hepatic fibrosis
    V Ratziu
    University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 95:9500-5. 1998
    ..A zinc finger transcription factor cDNA, zf9, was cloned from rat stellate cells activated in vivo...
  20. ncbi Transcriptional activation of endoglin and transforming growth factor-beta signaling components by cooperative interaction between Sp1 and KLF6: their potential role in the response to vascular injury
    Luisa M Botella
    Centro de Investigaciones Biologicas, Consejo Superior Investigaciones Cientificas CSIC, Madrid, Spain
    Blood 100:4001-10. 2002
    ..The transcription factor KLF6, an immediate-early response gene induced in endothelial cells during vascular injury, transactivates TGF-beta, TGF-..
  21. pmc Deletion, mutation, and loss of expression of KLF6 in human prostate cancer
    Ceshi Chen
    Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA
    Am J Pathol 162:1349-54. 2003
    ..In a recent study, KLF6 was reported as a tumor suppressor gene in prostate cancer because of its frequent loss of heterozygosity (LOH) and ..
  22. ncbi A germline DNA polymorphism enhances alternative splicing of the KLF6 tumor suppressor gene and is associated with increased prostate cancer risk
    Goutham Narla
    Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA
    Cancer Res 65:1213-22. 2005
    ..We first showed that KLF6 is a tumor suppressor somatically inactivated in prostate cancer and since then, its functional loss has been ..
  23. ncbi Krüppel-like factor-6 promotes preadipocyte differentiation through histone deacetylase 3-dependent repression of DLK1
    Dan Li
    Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 280:26941-52. 2005
    ..We have identified Krüppel-like factor-6 (KLF6), a recently described tumor suppressor gene, as a repressor of the proto-oncogene Delta-like 1 (Dlk1), a gene ..
  24. ncbi Absence of mutation in the putative tumor-suppressor gene KLF6 in colorectal cancers
    Astrid Lievre
    1INSERM U490 Laboratoire de Toxicologie Moléculairei, Universite Rene Descartes, 75006 Paris, France
    Oncogene 24:7253-6. 2005
    The KLF6 gene encodes the Krüppel-like factor 6, a transcription factor that has been individualized as a tumor-suppressor gene involved in the regulation of cell proliferation and differentiation...
  25. ncbi Roles of KLF6 and KLF6-SV1 in ovarian cancer progression and intraperitoneal dissemination
    Analisa Difeo
    Department of Human Genetics, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, New York 10029, USA
    Clin Cancer Res 12:3730-9. 2006
    We investigated the role of the KLF6 tumor suppressor gene and its alternatively spliced isoform KLF6-SV1 in epithelial ovarian cancer (EOC).
  26. ncbi KLF6 degradation after apoptotic DNA damage
    Michaela S Banck
    Department of Medicine, Division of Hematology Oncology, P O Box 1079, Mount Sinai School of Medicine, One Gustave Levy Place, Room 24 42A, New York, NY 10029, USA
    FEBS Lett 580:6981-6. 2006
    Krüppel-like factor 6 (KLF6) is a cancer gene ()...
  27. ncbi Difference in the role of loss of heterozygosity at 10p15 (KLF6 locus) in colorectal carcinogenesis between sporadic and familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer patients
    Michiko Miyaki
    Hereditary Tumor Research Project, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan
    Oncology 71:131-5. 2006
    To clarify the role of the KLF6 (Kruppel-like factor 6) locus in multistep colorectal carcinogenesis, we analyzed loss of heterozygosity (LOH) at 10p15 (KLF6 locus) and mutations of the KLF6gene in 298 colorectal tumors at various ..
  28. ncbi Functional inactivation of the KLF6 tumor suppressor gene by loss of heterozygosity and increased alternative splicing in glioblastoma
    Olga Camacho-Vanegas
    Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA
    Int J Cancer 121:1390-5. 2007
    ..The KLF6 (Kruppel-like transcription factor) tumor suppressor gene on 10p15 is inactivated by loss of heterozygosity (LOH) ..
  29. ncbi KLF6 allelic loss is associated with tumor recurrence and markedly decreased survival in head and neck squamous cell carcinoma
    Miriam S Teixeira
    Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA
    Int J Cancer 121:1976-83. 2007
    The Krüppel-like transcription factor (KLF6) gene is a tumor suppressor gene (TSG) reported to be dysregulated and inactivated through loss of heterozygosity (LOH) and/or somatic mutation in a number of major human cancers...
  30. pmc Tissue factor pathway inhibitor-2 was repressed by CpG hypermethylation through inhibition of KLF6 binding in highly invasive breast cancer cells
    Hongshen Guo
    Key Laboratory of Molecular Medicine, Ministry of Education, Yixueyuan Road 138, Shanghai Medical College, Fudan University, Shanghai 200032, China
    BMC Mol Biol 8:110. 2007
    ..Here, we have investigated the mechanism of DNA methylation on the repression of TFPI-2 in breast cancer cell lines...
  31. ncbi KLF6 IVS1 -27G/A polymorphism with susceptibility to gastric cancers in Korean
    Y G Cho
    Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Neoplasma 55:47-50. 2008
    b>KLF6 is a key cell cycle regulator that is downregulated in several kinds of human cancers, including gastric cancer...
  32. pmc A functional role for KLF6-SV1 in lung adenocarcinoma prognosis and chemotherapy response
    Analisa Difeo
    Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York 10029, USA
    Cancer Res 68:965-70. 2008
    Kruppel-like factor 6 (KLF6) is a tumor suppressor gene that is functionally inactivated in human cancer by loss of heterozygosity, somatic mutation, decreased expression, and increased alternative splicing into an oncogenic splice ..
  33. pmc KLF6-SV1 overexpression accelerates human and mouse prostate cancer progression and metastasis
    Goutham Narla
    Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Invest 118:2711-21. 2008
    ..Here we demonstrated that increased expression of a splice variant of the Kruppel-like factor 6 (KLF6) tumor suppressor gene, known as KLF6-SV1, in tumors from men after prostatectomy predicted markedly poorer ..
  34. doi Increased alternative splicing of the KLF6 tumour suppressor gene correlates with prognosis and tumour grade in patients with pancreatic cancer
    Mark Hartel
    Department of Surgery, University of Heidelberg, Germany Department of Surgery, Technische Universitat Munchen, Munich, Ismaninger Strasse 22, D 81675 Munich, Germany
    Eur J Cancer 44:1895-903. 2008
    The aim of this study was to correlate the status of the KLF6 tumour suppressor gene including loss of heterozygosity (LOH), mutation and alternative splicing in human pancreatic cancer with tumour grade and survival...
  35. doi KLF6 and TP53 mutations are a rare event in prostate cancer: distinguishing between Taq polymerase artifacts and true mutations
    Laia Agell
    Department of Pathology, Hospital del Mar, Barcelona, Spain
    Mod Pathol 21:1470-8. 2008
    Krüppel-like factor 6 (KLF6) has been reported to act as a tumor suppressor gene involved in the regulation of the cell cycle by activating p21 in a p53-independent manner...
  36. doi The role of KLF6 and its splice variants in cancer therapy
    Analisa Difeo
    Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA
    Drug Resist Updat 12:1-7. 2009
    The Krüppel-like zinc finger transcription factor (KLF6) gene encodes a family of proteins generated through alternative splicing involved in the regulation of cancer development and progression...
  37. pmc Functional role of the KLF6 tumour suppressor gene in gastric cancer
    Jaya Sangodkar
    Department of Medicine, Mount Sinai School of Medicine, New York, NY, United States
    Eur J Cancer 45:666-76. 2009
    ..The Kruppel-like factor 6 (KLF6) tumour suppressor gene had been previously shown to be inactivated in a number of human cancers through loss of ..
  38. ncbi Activation of protein kinase C by phorbol 12-myristate 13-acetate suppresses the growth of lung cancer cells through KLF6 induction
    Eiji Tahara
    Department of Thoracic Head and Neck Medical Oncology, University of Texas, M D Anderson Cancer Center, Houston, TX, USA
    Cancer Biol Ther 8:801-7. 2009
    ..Kruppel-like transcription factor 6 (KLF6), which is associated with negative control of cell proliferation, is downregulated in many cancers, including ..
  39. doi Biology of Krüppel-like factor 6 transcriptional regulator in cell life and death
    Verónica Andreoli
    Centro de Investigaciones en Bioquímica Clínica e Inmunología CIBICI CONICET, Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Cordoba, Argentina
    IUBMB Life 62:896-905. 2010
    ..A member of this group, Krüppel-like factor 6 (KLF6), identified on the basis of its ability to regulate a group of genes belonging to the carcinoembryonic antigen ..
  40. doi Deregulated expression of Kruppel-like factors in acute myeloid leukemia
    Magali Humbert
    Department of Clinicial Research, Experimental Oncology and Hematology, University of Bern, and Department of Hematology, Inselspital, Bern University Hospital, Bern, Switzerland
    Leuk Res 35:909-13. 2011
    ..We found that KLF2, KLF3, KLF5 and KLF6 are significantly lower expressed in AML blast and CD34+ progenitor cells as compared to normal granulocytes...
  41. pmc Krüppel-like factor 6 regulates transforming growth factor-β gene expression during human respiratory syncytial virus infection
    Victoria Mgbemena
    Department of Microbiology and Immunology, The University of Texas Health Science Center at San Antonio, USA
    Virol J 8:409. 2011
    ..Previous studies have shown that Kruppel-like factor 6 (KLF6) could function as a trans-activator of TGF gene; however, whether KLF members play a role during infection is ..
  42. ncbi KLF6, a putative tumor suppressor gene, is mutated in astrocytic gliomas
    Yung Ming Jeng
    Department of Pathology, National Taiwan University Hospital, No 7 Chung Shan Road, Taipei 100, Taiwan
    Int J Cancer 105:625-9. 2003
    ..Recently, a candidate tumor suppressor gene, KLF6, which is mapped to chromosome 10p, was found to be frequently mutated in prostate cancer...
  43. ncbi Kruppel-like factor 6 (KLF6) is a tumor-suppressor gene frequently inactivated in colorectal cancer
    Helen L Reeves
    Division of Liver Diseases, Mount Sinai School of Medicine, New York, NY 10029, USA
    Gastroenterology 126:1090-103. 2004
    Kruppel-like factor 6 (KLF6) is a ubiquitous zinc finger tumor suppressor that is often mutated in prostate cancer...
  44. ncbi Genetic alterations of the KLF6 gene in gastric cancer
    Yong Gu Cho
    Department of Pathology, College of Medicine, The Catholic University of Korea, 505 Banpo Dong, Seocho Gu, Seoul 137 701, Korea
    Oncogene 24:4588-90. 2005
    The KLF6 is a zinc-finger tumor suppressor that is frequently mutated in several human cancers and broadly involved in differentiation and development, growth-related signal transduction, cell proliferation, apoptosis, and angiogenesis...
  45. ncbi E-cadherin is a novel transcriptional target of the KLF6 tumor suppressor
    A Difeo
    Department of Human Genetics, The Mount Sinai School of Medicine, New York, NY 10029, USA
    Oncogene 25:6026-31. 2006
    The tumor suppressor KLF6 is a member of the Krüppel-like family of transcription factors, which has been implicated in the pathogenesis of several human carcinomas...
  46. ncbi Genome-wide single nucleotide polymorphism analysis of lung cancer risk detects the KLF6 gene
    Monica Spinola
    Department of Experimental Oncology and Laboratories, Istituto Nazionale Tumori, Via G Venezian 1, 20133 Milan, Italy
    Cancer Lett 251:311-6. 2007
    ..DNA pooling analysis identified rs10508266 SNP, located approximately 12.5kb from the 5'-end of the KLF6 gene, as a marker showing significant association with lung cancer risk...
  47. pmc Ras promotes growth by alternative splicing-mediated inactivation of the KLF6 tumor suppressor in hepatocellular carcinoma
    Steven Yea
    Division of Liver Diseases and Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA
    Gastroenterology 134:1521-31. 2008
    ..The Krüppel-like factor 6 (KLF6) gene is a zinc finger transcription factor that inhibits cellular growth in part by transcriptional activation of ..
  48. ncbi [Mutation analysis of KLF6 gene in human nasopharyngeal carcinomas]
    Han Kui Chen
    Cancer Center, Sun Yat Sen University, Guangzhou 510060, P R China
    Ai Zheng 21:1047-50. 2002
    ..However, the molecular pathology of NPC is unclear yet. Kruppel-like factor 6(KLF6) is a ubiquitously expressed nuclear transcription factor, which is deleted and/or mutated with high frequency in a ..
  49. ncbi Role of circadian rhythm and endogenous melatonin in pathogenesis of acute gastric bleeding erosions induced by stress
    T Brzozowski
    Department of Physiology, Jagiellonian University Medical College, 16 Grzegorzecka Street, Cracow, Poland
    J Physiol Pharmacol 58:53-64. 2007
    ..promoting mucosal damage and the gastric mucosal defense mechanisms including predominantly gastric blood flow (GBF), biosynthesis of gastroprotective prostaglandins (PG) and enhanced mucus/bicarbonate secretion...
  50. ncbi Helicobacter pylori infection delays healing of ischaemia-reperfusion induced gastric ulcerations: new animal model for studying pathogenesis and therapy of H. pylori infection
    S J Konturek
    Department of Physiology and Pathomorphology, Jagiellonian University School of Medicine, Cracow, Poland
    Eur J Gastroenterol Hepatol 12:1299-313. 2000
    ..In this study we developed the new model of gastric Hp infection in rat gastric mucosa, with acute gastric erosions progressing into ulcers in animals subjected initially to ischaemia-reperfusion (I/R)...
  51. ncbi Pituitary adenylyl cyclase-activating polypeptide (PACAP) and its receptor (PAC1-R) are positioned to modulate afferent signaling in the cochlea
    M J Drescher
    Laboratory of Bio Otology, Department of Otolaryngology, Wayne State University School of Medicine, 261 Lande Medical Research Building, 540 East Canfield Avenue, Detroit, MI 48201, USA
    Neuroscience 142:139-64. 2006
    ..polypeptide (PACAP), via its specific receptor pituitary adenylyl cyclase-activating polypeptide receptor 1 (PAC1-R), is known to have roles in neuromodulation and neuroprotection associated with glutamatergic and cholinergic ..
  52. ncbi Pituitary adenylate cyclase-activating polypeptide (PACAP) and PACAP-receptor type 1 expression in rat and human placenta
    M L Scaldaferri
    Department of Internal Medicine, University of TorVergata, Rome, Italy
    Endocrinology 141:1158-67. 2000
    ..family of neuropeptides, exerts its biological action by interacting with both PACAP-selective type I receptors (PAC1) and type II receptors (VPAC1), which bind both PACAP and VIP...
  53. ncbi Healing of chronic gastric ulcers in diabetic rats treated with native aspirin, nitric oxide (NO)-derivative of aspirin and cyclooxygenase (COX)-2 inhibitor
    I Brzozowska
    Department of Physiology, Jagiellonian University Medical College, 31 531 Cracow, ul Grzegorzecka 16, Poland
    J Physiol Pharmacol 55:773-90. 2004
    ..g.). Ten days after the induction of the ulcers, the healing rate and the gastric blood flow (GBF) were measured by planimetry and hydrogen (H(2))-gas clearance method, respectively and the plasma cytokine such as ..
  54. ncbi Pituitary adenylyl cyclase-activating polypeptide (PACAP) and its receptor (PAC1-R) in the cochlea: evidence for specific transcript expression of PAC1-R splice variants in rat microdissected cochlear subfractions
    M D Abu-Hamdan
    Laboratory of Bio Otology, Department of Otolaryngology, Wayne State University School of Medicine, 261 Lande Medical Research Building, 540 East Canfield Avenue, Detroit, MI 48201, USA
    Neuroscience 140:147-61. 2006
    ..PACAP acts through the specific receptor PAC1-R to modulate the action of neurotransmitters, and additionally, to regulate cell viability via autocrine/..
  55. ncbi Importance of luminal and mucosal zinc in the mechanism of experimental gastric ulcer healing
    W Opoka
    Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Cracow, Poland
    J Physiol Pharmacol 61:581-91. 2010
    ..the termination of each treatment, the area of gastric ulcers were examined by planimetry, the gastric blood flow (GBF) at ulcer margin was assessed by laser Doppler flowmetry and H(2)-gas clearance methods...
  56. doi Distribution and functional characterization of pituitary adenylate cyclase-activating polypeptide receptors in the brain of non-human primates
    V Jolivel
    Institut National de la Santé et de la Recherche Médicale U413, EA 4310, Neuronal and Neuroendocrine Differentiation and Communication, European Institute for Peptide Research IFRMP23, University of Rouen, 76821 Mont Saint Aignan, France
    Neuroscience 160:434-51. 2009
    ..encoding the short and hop-1 variants of pituitary adenylate cyclase-activating polypeptide-specific receptor (PAC1-R) in the cortex of both marmoset and macaque, whereas vasoactive intestinal polypeptide/pituitary adenylate ..
  57. ncbi The Kruppel-like factor Zf9 and proteins in the Sp1 family regulate the expression of HSP47, a collagen-specific molecular chaperone
    Kunihiko Yasuda
    Department of Molecular and Cellular Biology, Institute for Frontier Medical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8397, Japan
    J Biol Chem 277:44613-22. 2002
    ..One of these proteins, KLF-6/Zf9, binds to the BS5-B element and activates expression of the reporter construct when transfected into cells...
  58. doi MMM-QSAR recognition of ribonucleases without alignment: comparison with an HMM model and isolation from Schizosaccharomyces pombe, prediction, and experimental assay of a new sequence
    Guillermin Agüero-Chapin
    Dipartimento Farmaco Chimico Tecnologico, Universita degli Studi di Cagliari, Cagliari, 09124, Italy
    J Chem Inf Model 48:434-48. 2008
    The study of type III RNases constitutes an important area in molecular biology. It is known that the pac1+ gene encodes a particular RNase III that shares low amino acid similarity with other genes despite having a double-stranded ..
  59. ncbi Effect of local injection with basic fibroblast growth factor (BFGF) and neutralizing antibody to BFGF on gastric ulcer healing, gastric secretion, angiogenesis and gastric blood flow
    H Ernst
    Department of Medicine I, University of Erlangen Nuremberg, Germany
    J Physiol Pharmacol 52:377-90. 2001
    ..without neutralizing antibody (NA) to bFGF and 2) to determine the role of gastric secretion, gastric blood flow (GBF) at the ulcer margin and angiogenesis during gastric ulcer healing with or without local application of NA, bFGF or ..
  60. ncbi Platelet activation in patients with obstructive sleep apnea syndrome and effects of nasal-continuous positive airway pressure
    Mie Shimizu
    Department of Laboratory Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Tokai J Exp Clin Med 27:107-12. 2002
    ....
  61. ncbi Characterisation of the promoter which regulates expression of a phosphoglucomutase-related protein, a component of the dystrophin/utrophin cytoskeleton predominantly expressed in smooth muscle
    E P Moiseeva
    Department of Biochemistry, University of Leicester, UK
    Eur J Biochem 248:634-43. 1997
    ..Here we show that the adult vascular smooth muscle cell line PAC1, which retains the capacity to synthesise metavinculin (a marker of the contractile phenotype) also expressed PGM-..
  62. doi The presence and distribution of pituitary adenylate cyclase activating polypeptide and its receptor in the snail Helix pomatia
    L Hernadi
    Department of Experimental Zoology, Balaton Limnological Research Institute, Hungarian Academy of Sciences, P O Box 35, H 8237 Tihany, Hungary
    Neuroscience 155:387-402. 2008
    ..PACAP-like and pituitary adenylate cyclase activating polypeptide receptor (PAC1-R)-like immunoreactivity was abundant both in the CNS and the peripheral nervous system of the snail...
  63. ncbi Influence of bacterial lipopolysaccharide on healing of chronic experimental ulcer in rat
    P C Konturek
    First Dept of Medicine, University Erlangen Nuremberg, Germany
    Scand J Gastroenterol 36:1239-47. 2001
    ..The aim of the present study was to examine the effect of parenteral injection of LPS at different doses on the course of ulcer healing in rats...
  64. ncbi Gut blood flow in fish during exercise and severe hypercapnia
    A P Farrell
    Department of Biological Sciences, Simon Fraser University, V5A 1S6, Burnaby, BC, Canada
    Comp Biochem Physiol A Mol Integr Physiol 128:551-63. 2001
    ..Brief struggling behaviours are known to decrease blood flow to the gut (GBF)...
  65. ncbi Are probiotics effective in the treatment of fungal colonization of the gastrointestinal tract? Experimental and clinical studies
    M Zwolińska-Wcisło
    Department of Gastroenterology, Hepatology and Infectious Diseases, Jagiellonian University Medical College, Cracow, Poland
    J Physiol Pharmacol 57:35-49. 2006
    ..g.). At 0, 4, 15 and 25 day after ulcer induction. Weight, damage area, gastric blood flow (GBF) (H2 clearance), expression of mRNA for cytokines IL-beta, TNF-alpha (ELISA) were evaluated...
  66. doi PACAP induces signaling and stimulation of 5-hydroxytryptamine release and growth in neuroendocrine tumor cells
    Patrizia M Germano
    Department of Medicine, University of California, CURE Digestive Diseases Research Center, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    J Mol Neurosci 39:391-401. 2009
    ..PACAP), released from the enteric neurons in the gastrointestinal tract by binding to its high affinity receptor PAC1, has been previously shown to regulate the secretory activity and growth of the neuroendocrine-derived ..
  67. ncbi Modification of intestinal flora in the treatment of inflammatory bowel disease
    Osamu Kanauchi
    Nutrient Food and Feed Division, Kirin Brewery Co Ltd, 10 1 2 Shinkawa Chuo ku, Tokyo, 104 8288, Japan
    Curr Pharm Des 9:333-46. 2003
    ..Prebiotics for IBD include lactosucrose, oligofructose, inulin, bran, psyllium, and germinated barley foodstuff (GBF)...
  68. ncbi Gastro-bronchial fistula after laparoscopic nissen fundoplication
    Walid Faraj
    Department of Surgery, American University of Beirut Medical Center, AUBMC, Beirut, Lebanon
    Surg Laparosc Endosc Percutan Tech 17:430-3. 2007
    Gastro-bronchial fistula (GBF) is an unusual complication of Nissen fundoplication, particularly when performed via a transabdominal approach...
  69. pmc A maize protein associated with the G-box binding complex has homology to brain regulatory proteins
    N C de Vetten
    Horticultural Sciences Department, University of Florida, Gainesville 32611
    Plant Cell 4:1295-307. 1992
    ..We used monoclonal antibodies generated against partially purified G-box binding factor (GBF) activity to characterize maize proteins that are part of the DNA binding complex...
  70. ncbi Dietary fiber fraction of germinated barley foodstuff attenuated mucosal damage and diarrhea, and accelerated the repair of the colonic mucosa in an experimental colitis
    O Kanauchi
    Applied Bioresearch Center, Corporate Research and Development Division, Kirin Brewery Co Ltd, Takasaki, Gunma, Japan
    J Gastroenterol Hepatol 16:160-8. 2001
    Germinated barley foodstuff (GBF) contains protein and insoluble dietary fiber. We have previously shown in ulcerative colitis patients and a colitis model that GBF feeding attenuates mucosal damage by increasing luminal butyrate levels...
  71. ncbi Agonist of peroxisome proliferator-activated receptor gamma (PPAR-gamma): a new compound with potent gastroprotective and ulcer healing properties
    Tomasz Brzozowski
    Department of Physiology, Jagiellonian University Medical College, 16 Grzegorzecka Street, 31 531 Cracow, Poland
    Inflammopharmacology 13:317-30. 2005
    ..ulcer induction, and the number and area of gastric lesions were measured by planimetry, the gastric blood flow (GBF) was determined by H2-gas clearance technique and the mucosal PGE2 generation and gene expression and plasma ..
  72. ncbi A constitutively active pituitary adenylate cyclase activating polypeptide (PACAP) type I receptor shows enhanced photoaffinity labeling of its highly glycosylated form
    Y Cao
    Institute of Biochemistry, Johannes Gutenberg University of Mainz, Becherweg 30, D 55099 Mainz, Germany
    Biochim Biophys Acta 1548:139-51. 2001
    ..a previously identified constitutively active pituitary adenylate cyclase activating polypeptide (PACAP) type I (PAC1) receptor with a deletion of the single amino acid residue Glu(261) (Y.-J. Cao, G. Gimpl, F...
  73. pmc PACAP-mediated ATP release from rat urothelium and regulation of PACAP/VIP and receptor mRNA in micturition pathways after cyclophosphamide (CYP)-induced cystitis
    Beatrice M Girard
    Department of Anatomy and Neurobiology, University of Vermont, Burlington, VT 05405, USA
    J Mol Neurosci 36:310-20. 2008
    ..studies have demonstrated roles for PACAP27 and PACAP38 in detrusor smooth muscle (DSM) contraction and a PAC1 receptor antagonist reduced cyclophosphamide (CYP)-induced bladder hyperreflexia...
  74. ncbi Tryptophan free diet delays healing of chronic gastric ulcers in rat
    P C Konturek
    First Department of Medicine, University Erlangen Nuremberg, Erlangen, Germany
    J Physiol Pharmacol 59:53-65. 2008
    ..effect of MT and L-Trp on healing of chronic gastric ulcer and accompanying changes in gastric mucosal blood flow (GBF); 2) to study the effect of MT and L-Trp on expression of iNOS...
  75. ncbi Expression of PACAP receptors in the frog brain during development
    Monica Ciarlo
    Department of Biology, University of Genova, V le Benedetto XV, 5, 16132 Genova, Italy
    Ann N Y Acad Sci 1070:201-4. 2006
    This study describes the expression of PAC1 and VPAC1 receptor (PAC1-R and VPAC1-R) mRNAs in the brain of frog (Rana esculenta) during development...
  76. ncbi An enzyme-linked immunosorbent assay to identify inhibitors of activation of platelet integrin alpha IIb beta 3
    J Gao
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    J Immunol Methods 181:55-64. 1995
    ..After the addition of biotin-PAC1, a fibrinogen-mimetic monoclonal antibody, the activation state of alpha IIb beta 3 was measured by sedimenting the ..
  77. ncbi Immunosuppressive therapy regimen and platelet activation in renal transplant patients
    Jochen Graff
    Pharmazentrum Frankfurt, Institute of Clinical Pharmacology, Funktionsbereich Nephrologie, Medizinische Klinik IV, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Clin Pharmacol Ther 72:411-8. 2002
    ..Cyclosporine (INN, ciclosporin) and azathioprine are reported to activate platelets, but data are rare and controversial for tacrolimus and mycophenolate mofetil...
  78. ncbi Smooth muscle--specific expression of CYP4A1 induces endothelial sprouting in renal arterial microvessels
    Miao Jiang
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Circ Res 94:167-74. 2004
    ..Beta-galactosidase expression was detected in Ad-SM22-nLacZ-transduced vascular smooth muscle A7r5 and PAC1 cells, but not in Ad-SM22-nLacZ-transduced 3T3 fibroblasts or vascular endothelial cells...
  79. ncbi Ageing and the diurnal expression of mRNAs for vasoactive intestinal peptide and for the VPAC2 and PAC1 receptors in the suprachiasmatic nucleus of male rats
    I Kallo
    Centre for Neuroscience Research, King s College London, London, UK
    J Neuroendocrinol 16:758-66. 2004
    ..These actions involve members of a distinct family of receptors; mRNAs for two such receptors, VPAC2 and PAC1, are present in the SCN...
  80. ncbi VIP enhances synaptic transmission to hippocampal CA1 pyramidal cells through activation of both VPAC1 and VPAC2 receptors
    Diana Cunha-Reis
    Institute of Pharmacology and Neurosciences, Faculty of Medicine, University of Lisbon, Av Prof Egas Moniz, 1649 028 Lisbon, Portugal
    Brain Res 1049:52-60. 2005
    ..cells at concentrations known to activate VIP-selective receptors (VPAC1 and VPAC2) but not the PACAP-selective PAC1 receptor...
  81. pmc Dynamics of platelet glycoprotein IIb-IIIa receptor expression and fibrinogen binding. I. Quantal activation of platelet subpopulations varies with adenosine diphosphate concentration
    M M Frojmovic
    Department of Physiology, McGill University, Montreal, Quebec, Canada
    Biophys J 67:2060-8. 1994
    ..causes rapid expression of all GPIIb-IIIa receptors for fibrinogen (FgR) (< 1-3 s), measured with FITC-labeled PAC1 by flow cytometry...
  82. ncbi Vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide receptor subtypes in human tumors and their tissues of origin
    J C Reubi
    Division of Cell Biology and Experimental Cancer Research, Institute of Pathology, University of Berne, Switzerland
    Cancer Res 60:3105-12. 2000
    ..The VIP/PACAP receptor subtypes VPAC1, VPAC2, and PAC1 were evaluated in these tissues by determining the rank order of potencies of VIP and PACAP as well as VPAC1- and ..
  83. ncbi The Sclerotinia sclerotiorum pac1 gene is required for sclerotial development and virulence
    Jeffrey A Rollins
    Department of Plant Pathology, 1453 Fifield Hall, University of Florida, Gainesville, FL 32611 0680, USA
    Mol Plant Microbe Interact 16:785-95. 2003
    ..by the PacC transcription factor in Aspergillus nidulans, we functionally characterized a pacC gene homolog, pac1, from S. sclerotiorum...
  84. ncbi Oxidative stress, KLF6 and transforming growth factor-beta up-regulation differentiate non-alcoholic steatohepatitis progressing to fibrosis from uncomplicated steatosis in rats
    Peter Starkel
    Laboratory of Gastroenterology, St Luc University Hospital, Universite Catholique de Louvain, Avenue Hippocrate 10, 1200 Brussels, Belgium
    J Hepatol 39:538-46. 2003
    ..The aim was to determine the potential implication of these factors in the progression from uncomplicated steatosis to steatohepatitis with progressive fibrosis...
  85. ncbi Importance of brain-gut axis in the gastroprotection induced by gastric and remote preconditioning
    T Brzozowski
    Department of Physiology, Jagiellonian University Medical College, Cracow, Poland
    J Physiol Pharmacol 55:165-77. 2004
    ..The area of gastric lesions was determined by planimetry, gastric blood flow (GBF) was measured by H(2)-gas clearance method and mucosal biopsy samples were taken for the assessment of calcitonin ..
  86. ncbi Ghrelin-a new gastroprotective factor in gastric mucosa
    P C Konturek
    Department of Medicine I, University Erlangen Nuremberg, Erlangen, Germany
    J Physiol Pharmacol 55:325-36. 2004
    ..At the end of experiments, the rats were anesthetized, the stomach was exposed to measure gastric blood flow (GBF), to determine the area of gastric lesions and to take biopsy samples from the oxyntic mucosa for determination of ..
  87. ncbi Developmentally regulated expression of KLF6 in the mouse cornea and lens
    Hiroshi Nakamura
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago College of Medicine, 1855 W Taylor Street, Chicago, IL 60612, USA
    Invest Ophthalmol Vis Sci 45:4327-32. 2004
    To examine the expression of transcription factor Kruppel-like factor-6 (KLF6) in the cornea and lens of mouse eyes throughout developmental stages.
  88. ncbi Immunocytochemical identification of VPAC1, VPAC2, and PAC1 receptors in normal and neoplastic human tissues with subtype-specific antibodies
    Solveig Schulz
    Department of Obstetrics and Gynecology, Otto von Guericke University, Magdeburg, Germany
    Clin Cancer Res 10:8235-42. 2004
    ..VPAC1, VPAC2, and PAC1 receptors were clearly located at the plasma membrane of the tumor cells in a variety of human neoplasms...
  89. ncbi [Function of glial G-protein coupled receptors]
    Akiko Furuta
    Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Brain Nerve 59:717-24. 2007
    ..Application of a Ntsr2 agonist modified the behavior of wild type mice. In NPCs, PACAP receptor (PAC1) was identified as one of the highly expressed GPCRs...
  90. pmc Vasoactive intestinal peptide acts via multiple signal pathways to regulate hippocampal NMDA receptors and synaptic transmission
    Kai Yang
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Hippocampus 19:779-89. 2009
    ..At least three receptors for VIP have been identified including the PACAP receptor (PAC1-R) and the two VIP receptors (VPAC receptors)...
  91. pmc PACAP/VIP and receptor characterization in micturition pathways in mice with overexpression of NGF in urothelium
    Beatrice M Girard
    Department of Anatomy and Neurobiology, University of Vermont, Burlington, VT 05405, USA
    J Mol Neurosci 42:378-89. 2010
    ..adenylate cyclase activating polypeptide (PACAP), vasoactive intestinal polypeptide (VIP), and associated receptor (PAC1, VPAC1, VPAC2) transcripts or protein expression in urothelium and detrusor smooth muscle and lumbosacral dorsal ..
  92. ncbi Activation of genes for spasmolytic peptide, transforming growth factor alpha and for cyclooxygenase (COX)-1 and COX-2 during gastric adaptation to aspirin damage in rats
    P C Konturek
    Department of Medicine I, University Erlangen Nuremberg, Germany
    Aliment Pharmacol Ther 12:767-77. 1998
    ..The mechanism of the gastric adaptation to the damage induced by ASA has not been fully explained...
  93. pmc Increased platelet count and leucocyte-platelet complex formation in acute symptomatic compared with asymptomatic severe carotid stenosis
    D J H McCabe
    University Department of Clinical Neurosciences, Royal Free and University College Medical School, The Royal Free Hospital Hampstead, Pond St, London NW3 2PF, England
    J Neurol Neurosurg Psychiatry 76:1249-54. 2005
    ..In the present study it was hypothesised that excessive platelet activation might partly contribute to this difference...
  94. doi Modulation of AMPA receptor-mediated ion current by pituitary adenylate cyclase-activating polypeptide (PACAP) in CA1 pyramidal neurons from rat hippocampus
    L Costa
    Dipartimento di Scienze Fisiologiche, Universita di Catania, Viale Andrea Doria 6, 95125 Catania, Italy
    Hippocampus 19:99-109. 2009
    ..5 nM dose, PACAP increased AMPA-mediated current; such effect was blocked by PACAP 6-38, a selective antagonist of PAC1 receptors. The enhancement of AMPA-mediated current by PACAP 0...
  95. ncbi Effects of angiotensin II, arginine vasopressin and tromboxane A2 in renal vascular bed: role of rho-kinase
    Alessandro Cavarape
    Department of Experimental and Clinical Pathology and Medicine, Chair of Internal Medicine, University of Udine, Udine, Italy
    Nephrol Dial Transplant 18:1764-9. 2003
    ..The aim of this study was to determine their sites of action in the renal vascular bed and the corresponding role of ROK at the microvascular level...
  96. ncbi Blood flow and interstitial fluid pressure in the rat submandibular gland during changes in perfusion
    E Berggreen
    Department of Physiology, Jonas Lies vei 91, University of Bergen, N 5009 Bergen, Norway
    J Dent Res 82:899-902. 2003
    ..To test this hypothesis, we measured IFP with micropipettes and glandular blood flow (GBF) with a laser-Doppler flowmeter during changes in perfusion...
  97. pmc Mutations in the pale aleurone color1 regulatory gene of the Zea mays anthocyanin pathway have distinct phenotypes relative to the functionally similar TRANSPARENT TESTA GLABRA1 gene in Arabidopsis thaliana
    Charles C Carey
    Department of Plant Sciences, University of Arizona, Tucson, Arizona 85721, USA
    Plant Cell 16:450-64. 2004
    The pale aleurone color1 (pac1) locus, required for anthocyanin pigment in the aleurone and scutellum of the Zea mays (maize) seed, was cloned using Mutator transposon tagging...
  98. ncbi PACAP regulation of secretion and proliferation of pure populations of gastric ECL cells
    David S Oh
    Division of Gastroenterology and Hepatology, Dept of Research and Development, VA Greater Los Angeles Healthcare System and CURE VA UCLA Digestive Disease Research Center, Dept of Medicine, David Geffen School of Medicine at UCLA, CA 90073, USA
    J Mol Neurosci 26:85-97. 2005
    ..Polypeptide (PACAP) is present on myenteric neurons in the rat and colocalizes with its high-affinity receptor, PAC1, expressed on the surface of gastric ECL cells...
  99. ncbi Neural aspects of ghrelin-induced gastroprotection against mucosal injury induced by noxious agents
    T Brzozowski
    Department of Physiology, Jagiellonian University Medical College, Cracow, Poland
    J Physiol Pharmacol 57:63-76. 2006
    ..The number and the area of gastric lesions was measured by planimetry, the GBF was assessed by H(2)-gas clearance method and blood was withdrawn for the determination of the plasma ghrelin and ..
  100. ncbi Expression localisation and functional activity of pituitary adenylate cyclase-activating polypeptide, vasoactive intestinal polypeptide and their receptors in mouse ovary
    Marzia Barberi
    Department of Histology and Medical Embriology, La Sapienza University of Rome, Via A Scarpa, 14, Rome 00161, Italy
    Reproduction 134:281-92. 2007
    ..These two peptides act by interacting with three types of receptors: PACAP type I receptor (PAC1-R), which binds with higher affinity to PACAP, and two VIP receptors (VPAC1-R and VPAC2-R), which bind to PACAP and ..
  101. ncbi Pharmacological evidence for both neuronal and smooth muscular PAC1 receptors and a VIP-specific receptor in rat colon
    E Ekblad
    Department of Physiological Sciences, Lund University Hospital, Sweden
    Regul Pept 85:87-92. 1999
    ..Tetraethylammonium (TEA) reduced VIP- but not PACAP-27-induced relaxations, while charybdotoxin was ineffective. Cross-desensitisation between PACAP-27, PACAP-38 and VIP could be revealed to some extent...

Research Grants51

  1. Valentina Sabino; Fiscal Year: 2016
    ..is that the endogenous PACAP system in the extended amygdala is recruited following exposure to stress and that PAC1 receptor antagonists exert an anxiolytic-like action...
  2. MARGARET ANN VIZZARD; Fiscal Year: 2016
    ..These studies examine the contributions of and interactions between the neuropeptide, PACAP, and receptor PAC1 and TRPV4 to increased voiding frequency and somatic sensitivity in NGF-OE mice...
  3. Bradford B Lowell; Fiscal Year: 2014
    ..neuropeptide, PACAP) (Aim 1), 2) the receptor and neuron immediately downstream of SF1 neurons (we propose that the PAC1-receptor - the high affinity PACAP receptor - on POMC neurons is important) (Aim 2), and 3) on the afferent side of ..
  4. James A Waschek; Fiscal Year: 2014
    ..In this regard, it was recently reported that the neuropeptide PACAP and its plasma membrane receptor PAC1 are linked to PTSD at both genetic and epigenetic levels...
  5. REGULATION OF PEPTIDE EXPRESSION IN NEURONAL CELLS
    Victor May; Fiscal Year: 2005
    ..production and secretion, established the preferential high expressior of only the PACAP-selective PAC1(short)HOP1 receptor splice variant in SCG neurons and demonstrated the unique coupling of PAC1 (short)HOP1 receptor ..
  6. Kerry J Ressler; Fiscal Year: 2016
    ..We have recently shown that PACAP and its PAC1 receptor (PAC1R) may be critical mediators of abnormal processes following psychological trauma, such as with ..
  7. Biomarkers for Posttraumatic Stress in Women Following a Campus Mass Shooting
    Holly K Orcutt; Fiscal Year: 2012
    ..To examine the impact of estrogen on PACAP-PAC1 gene expression, it is hypothesized that ADCYAP1R1 methylation levels will be most strongly related to PTSS among ..
  8. MAVIS AMITY IRWIN; Fiscal Year: 2014
    ..Both PACAP and its G-protein coupled receptor (PAC1) are highly expressed in the olfactory bulb (OB) throughout life suggesting PACAP plays an important role in the ..
  9. PACAP signaling in stress and anxiety
    William A Carlezon; Fiscal Year: 2012
    ..We will examine PACAP antagonists, which are highly selective for PACAP (PAC1) receptors but not previously tested in stress studies, and kappa-opioid receptor (KOR) antagonists, which have ..
  10. William A Carlezon; Fiscal Year: 2016
    ..We will examine classes of agents that are selective for PACAP (PAC1) receptors and VIP/PACAP (VPAC1) receptors, neither of which has been previously tested in stress studies, as well ..
  11. Sayamwong E Hammack; Fiscal Year: 2016
    ..we have also recently shown that circulating PACAP levels and a unique single nucleotide polymorphism in the PAC1 receptor predict PTSD symptoms and diagnosis in women, suggesting that PACAP systems are indeed altered in anxiety ..
  12. Caffeine regulates splicing of cancer-related genes: dissecting the mechanism
    Kathleen W Scotto; Fiscal Year: 2011
    ..human diet, induces alternative splicing of a large subset of cancer-related genes including the tumor suppressor KLF6. Using KLF6 as a prototype, we have shown that this induction is rapid and reversible and occurs at the level of ..
  13. FUNCTIONS OF PACAP IN OLFACTORY NEURONS
    Mary Lucero; Fiscal Year: 2009
    ..In three specific aims, we will determine: (1) the expression profiles of PACAP and isoforms of its receptor (PAC1) in the developing and adult OE of wild-type and PACAP ko mice with and without bulb ablation;(2) the contributions ..
  14. Structure and function of proteasome biogenesis associated proteins 1 and 2
    Erik Kish-Trier; Fiscal Year: 2013
    ..Recently, a heterodimeric Proteasome Associated Biogenesis factor (Pba1/2 in yeast;PAC1/2 in mammals) has been discovered that acts as a 20S assembly chaperone...
  15. Understanding the biological activity of Cthrc1 cleavage fragments
    RENEE LECLAIR; Fiscal Year: 2010
    ..be assessed in vitro using a collagen deposition assay in smooth muscle cells and luciferase reporter assay using PAC1 cells stably transfected with the TGF-B sensitive (CAGA) 12-Luc reporter...
  16. Programs in Clinical Effectiveness of Cancer Pharmacogenomics
    Geoffrey S Ginsburg; Fiscal Year: 2010
    ..at Duke - the Duke Institute for Genome Sciences &Policy Cancer Pharmacogenomic Biomarkers Program (IGSP-CPBP), the IGSP Clinical Genomics Studies Unit (IGSP-CGSU), and the Duke Health Services, Effectiveness and Outcomes ..
  17. The Role of KLF6 Tumor Suppressor in Hepatocellular Cancer
    SCOTT LAURENCE FRIEDMAN; Fiscal Year: 2010
    ..challenge in investigative hepatology The overall goal of this application is to elucidate the role of the KLF6 tumor suppressor in hepatocellular homeostasis, injury and cancer...
  18. Oxidant Stress and Fibrosis in Alcoholic Liver Injury
    SCOTT LAURENCE FRIEDMAN; Fiscal Year: 2012
    ..disease by studying the roles of oxidant stress, cell-cell interactions and a novel transcriptional regulator, KLF6, in mediating liver injury and fibrogenesis;2) Define novel models of alcoholic liver injury, non-alcoholic ..
  19. PLATELET SUFACE ACTIVATION IN HEMOSTASIS AND THROMBOSIS
    SANFORD SHATTIL; Fiscal Year: 1993
    ..Third, an antigen-antibody interaction will be studies as a model for integrin-fibrinogen interactions. PAC1 is an antibody specific for activated GP IIb-IIIa and its antibody-combining site mimics GP IIb-IIIa recognition ..
  20. Neuroprotection by PACAP in Stroke
    Akira Arimura; Fiscal Year: 2003
    ..of PACAP requires activation of astrocytes, and possibly microglia, which express the specific PACAP receptor (PAC1-R)...
  21. PACAP REGULATION OF NEUROGENESIS AND SURVIVAL
    Emanuel Dicicco Bloom; Fiscal Year: 2009
    ..2) Characterize the roles of PACAP anti-mitogenic pathway components, specifically PAC1 receptor and CDK inhibitor p57, in promoting cell cycle exit and determining cell fate using deletion mutants...
  22. HERPES SIMPLEX VIRUS TERMINASES
    Joel Baines; Fiscal Year: 2007
    ..The UL28 protein has been shown in vitro to bind Pac1 DNA (a sequence that is necessary for formation of the terminus of the short component of viral DNA)...
  23. STRUCTURE/FUNCTION OF THE MAPK PHOSPHATASE--PAC1
    Ming Ming Zhou; Fiscal Year: 2003
    ..To achieve these goals, we will study PAC1 as a model enzyme because it functions as the physiologically relevant MKP and plays an important role in the ..
  24. Cellular and Molecular Mechanisms of Mammalian Ovulation
    Ok Kyong Park Sarge; Fiscal Year: 2002
    ..system for pituitary adenylate cyclase activating polypeptide (PACAP): PACAP and its receptor type 1 (PAC1)...
  25. REGULATION OF THE HUMAN INOS GENE IN SEPSIS AND TRAUMA
    David Geller; Fiscal Year: 2007
    ..Further functional roles have been demonstrated for AP-1, C/EBPbeta (LAP), and KLF6. Importantly, we have identified mechanisms for hiNOS repression that involve NF-kappaB repressing factor (NRF), ..
  26. KLF6 Gene and Clinical Correlates in Prostate Cancer
    Anna Ferrari; Fiscal Year: 2005
    After successful local control, 35% of patients with prostate cancer (PC) experience progression. KLF6 is a transcription factor with growth inhibitory activity through induction of p21 (Waf1/Cip1)...
  27. The Function of Dynein in Budding Yeast
    John Cooper; Fiscal Year: 2009
    ..We discovered that LIS1/Pac1 is necessary for targeting dynein to plus ends and for dynein function...
  28. Role of IFI 16 in Cellular Senescence and Aging
    Divaker Choubey; Fiscal Year: 2003
    ..We will test whether the transcription factor KLF6, a candidate for tumor suppressor, activates transcription of the IFI 16 gene...
  29. Regulation of Neural Precursors: Role of Neuropeptides
    James Waschek; Fiscal Year: 2006
    ..The work may lead to new strategies for the diagnosis and treatment of diseases of brain development, degenerative diseases and brain tumors. ..
  30. Gene Targeting to Study Light-induced Circadian Changes
    James Waschek; Fiscal Year: 2003
    ..Moreover, the same targeting system should have utility in investigating individual components of the clock, such as PER, CRY, BMAL and CLOCK proteins. ..
  31. PKA modulation of hedgehog: a mouse medulloblastoma model
    James Waschek; Fiscal Year: 2009
    ..abstract_text> ..
  32. PAC1 in Signaling Apoptosis and Tumor Suppression
    Yuxin Yin; Fiscal Year: 2008
    ..We have recently reported that p53 is a direct transcriptional regulator of PAC1, a dual-specific threonine and tyrosine phosphatase with stringent substrate specificity for MAP kinase...
  33. MECHANISMS OF CUTANEOUS ACTIVE VASODILATION
    Dean Kellogg; Fiscal Year: 2008
    ..2) To determine whether activation of VPAC1 and/or PAC1 receptors mediate cutaneous active vasodilation during hyperthermia...
  34. Role of Nonclassical Transmitters in Cardiac Ganglia
    Donald Hoover; Fiscal Year: 2004
    ..abstract_text> ..
  35. Traffic of catecholamine storage vesicle proteins
    Laurent Taupenot; Fiscal Year: 2005
    ..The results of these studies will enhance our knowledge of catecholamine/granins storage and release during sympathetic stimulation, leading to a better understanding of neuroendocrine secretory granule biogenesis . ..
  36. Adenylyl Cyclase Signaling in Ear Sensory Eipthelia
    MARIAN DRESCHER; Fiscal Year: 2009
    ..The elucidation of these AC-mediated signal transduction pathways in inner ear sensory epithelia may allow eventual pharmacological amelioration of tinnitus, sensorinetiral deafness and vertigo. ..
  37. UTEROFERRIN GENE EXPRESSION DURING DEVELOPMENT
    ROSALIA SIMMEN; Fiscal Year: 2008
    ..This research will provide novel mechanistic insights into PR signaling involving PR coregulators that have relevance to human subfertility and hormone-dependent gynecological diseases. ..
  38. MOLECULAR NETWORKS THAT COORDINATE DIFFERENTIATION
    William Loomis; Fiscal Year: 2003
    ..Together these studies will help to establish a signal transduction pathway that can serve as a model for studies in other systems. ..
  39. A PR-Induced Autocrine/Paracrine Pathway in Female Brain
    EDE APOSTOLAKIS; Fiscal Year: 2004
    ..the steroid-induced mechanism(s) and its major components (VMN expression pattern of membrane-bound receptors [PAC1, VPAC, VPAC2]; signaling pathway [cAMP, MAPK] by which PACAP mediates isoform-specific PR- facilitated behavior...
  40. The MDR1 enhancesome--its activation and inhibition
    KATHLEEN SCOTTO; Fiscal Year: 2004
    ....
  41. Intercellular signaling during terminal differentiation
    William Loomis; Fiscal Year: 2009
    ..Together these studies will add to the foundation for improvements in the diagnosis and treatment of neurological diseases. ..
  42. Novel mode of p53 mediated repression the mdri paradigm
    KATHLEEN SCOTTO; Fiscal Year: 2004
    ..abstract_text> ..
  43. Functional Genomics of Dictyostelium Development
    William Loomis; Fiscal Year: 2005
    ..3) The full developmental roles of the transcription factors MybB, GBF, STAT1, and MybC will be assessed by comparing cluster profiles in mutant strains lacking these factors to those in ..
  44. In vivo Regulation of Cytoplasmic Dynein
    Xin Xiang; Fiscal Year: 2009
    ..Our third aim is to create null-mutants of several proteins in the dynein complex to study their functions in dynein regulation, and identify novel dynein regulators by cloning additional nud genes. ..
  45. TRANSCRIPTOME OF METASTATIC PROSTATE CANCER
    Gennadi Glinsky; Fiscal Year: 2005
    ..Subsequently the expression profile of these protein products will be studied in human prostate tumor samples by immunofluorescence analysis and immunohistochemistry to better correlate gene expression changes with phenotype. ..
  46. Mechanisms of Response to GnRH Receptor Signaling
    MARK LAWSON; Fiscal Year: 2005
    ..Isolation of actively translated and total mRNA from treated and control cells will allow identification and quantification of global changes in gene expression. ..
  47. Redox-Active Agents for Pancreatic Cancer
    Robert Dorr; Fiscal Year: 2009
    ..The underlying clinical trial is underway and has already produced objective evidence of efficacy for this drug combination. ..
  48. Insulin Signaling in the Anterior Pituitary
    MARK LAWSON; Fiscal Year: 2006
    ....
  49. Role of KLF6 in the DNA damage response and apoptosis
    Michaela Banck; Fiscal Year: 2008
    unreadable] DESCRIPTION (provided by applicant): [unreadable] KLF6 is a tumor suppressor gene that is frequently altered in ganstrointestinal tumors (colon, liver, stomach)...
  50. Synaptic Plasticity and Extinction of Fear
    Kerry Ressler; Fiscal Year: 2007
    ..Emory University and the Center for Behavioral Neuroscience provide an excellent environment for career development and training in the field of behavioral neuroscience. ..
  51. Molecular Regulation of GABA(A) Receptor Function in Amygdala
    Kerry J Ressler; Fiscal Year: 2010
    ..Understanding the mechanisms shared by stress and drug response is critical for understanding pathophysiology and proposing new treatments for these highly comorbid disorders. ..