KLF4

Summary

Gene Symbol: KLF4
Description: Kruppel like factor 4
Alias: EZF, GKLF, Krueppel-like factor 4, Kruppel-like factor 4 (gut), endothelial Kruppel-like zinc finger protein, epithelial zinc finger protein EZF, gut Kruppel-like factor, gut-enriched krueppel-like factor
Species: human

Top Publications

  1. pmc MicroRNA-10b promotes migration and invasion through KLF4 in human esophageal cancer cell lines
    Yanyan Tian
    Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
    J Biol Chem 285:7986-94. 2010
  2. doi KLF4 is a tumor suppressor in B-cell non-Hodgkin lymphoma and in classic Hodgkin lymphoma
    Hanfeng Guan
    Institute of Physiological Chemistry, University of Ulm, Germany
    Blood 116:1469-78. 2010
  3. pmc Krüppel-like factor 4, a tumor suppressor in hepatocellular carcinoma cells reverts epithelial mesenchymal transition by suppressing slug expression
    Ze Shiang Lin
    National Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan
    PLoS ONE 7:e43593. 2012
  4. pmc Haploinsufficiency of Krüppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesis
    Amr M Ghaleb
    Division of Digestive Diseases, Department of Medicine, and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30033, USA
    Cancer Res 67:7147-54. 2007
  5. pmc Opposing effects of Krüppel-like factor 4 (gut-enriched Krüppel-like factor) and Krüppel-like factor 5 (intestinal-enriched Krüppel-like factor) on the promoter of the Krüppel-like factor 4 gene
    Duyen T Dang
    Division of Gastroenterology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Nucleic Acids Res 30:2736-41. 2002
  6. pmc Overexpression of Krüppel-like factor 4 in the human colon cancer cell line RKO leads to reduced tumorigenecity
    Duyen T Dang
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Oncogene 22:3424-30. 2003
  7. ncbi Nuclear localization of KLF4 is associated with an aggressive phenotype in early-stage breast cancer
    Ashka Y Pandya
    Department of Cell Biology, University of Alabama at Birmingham, 35294, USA
    Clin Cancer Res 10:2709-19. 2004
  8. pmc Putative tumor-suppressive function of Kruppel-like factor 4 in primary lung carcinoma
    Wenxian Hu
    Sir Run Run Shaw Hospital, Zhejiang University, Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, People s Republic of China
    Clin Cancer Res 15:5688-95. 2009
  9. pmc Notch inhibits expression of the Krüppel-like factor 4 tumor suppressor in the intestinal epithelium
    Amr M Ghaleb
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
    Mol Cancer Res 6:1920-7. 2008
  10. pmc KLF4 is a novel candidate tumor suppressor gene in pancreatic ductal carcinoma
    Francesca Zammarchi
    Department of Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Am J Pathol 178:361-72. 2011

Research Grants

  1. TSHR and thyrocyte development
    Reigh Yi Lin; Fiscal Year: 2013
  2. Generation of Human iPS Cells via Non-integrating Vectors
    Wen Shu Wu; Fiscal Year: 2010
  3. Function of KLF4-expressing stem cells in mouse cutaneous wound healing
    Walden Ai; Fiscal Year: 2013
  4. Cardiovascular and Therapeutic Potential of Reprogrammed Human Fibroblasts
    WILLIAM ROBB MACLELLAN; Fiscal Year: 2010
  5. Role of Kruppel-Like Factor 4 in Wnt and Notch Signaling in the Intestinal Tract
    Amr Ghaleb; Fiscal Year: 2010
  6. Aging and Reprogramming of Somatic Cells to Pluripotency
    Peter J Hornsby; Fiscal Year: 2010
  7. Role of miR-145 in Vascular Smooth Muscle Cell BiologyRole of
    Chunxiang Zhang; Fiscal Year: 2013
  8. Mana M Parast; Fiscal Year: 2014
  9. Ming Ming Zhou; Fiscal Year: 2014
  10. Nuclear Reprogramming and Phenotype in Cloned Embryos
    Keith E Latham; Fiscal Year: 2013

Detail Information

Publications219 found, 100 shown here

  1. pmc MicroRNA-10b promotes migration and invasion through KLF4 in human esophageal cancer cell lines
    Yanyan Tian
    Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
    J Biol Chem 285:7986-94. 2010
    ..Additionally, we identified KLF4, a known tumor suppressor gene that has been reported to suppress esophageal cancer cell migration and invasion, as ..
  2. doi KLF4 is a tumor suppressor in B-cell non-Hodgkin lymphoma and in classic Hodgkin lymphoma
    Hanfeng Guan
    Institute of Physiological Chemistry, University of Ulm, Germany
    Blood 116:1469-78. 2010
    The transcription factor KLF4 may act both as an oncogene and a tumor suppressor in a tissue-depending manner. In T- and pre-B-cell lymphoma, KLF4 was found to act as tumor suppressor...
  3. pmc Krüppel-like factor 4, a tumor suppressor in hepatocellular carcinoma cells reverts epithelial mesenchymal transition by suppressing slug expression
    Ze Shiang Lin
    National Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan
    PLoS ONE 7:e43593. 2012
    Krüppel-like factor 4 (KLF4) is a zinc-finger transcription factor that plays an important role in differentiation and pathogenesis. KLF4 has been suggested to act as an oncogene or tumor suppressor in different tumor types...
  4. pmc Haploinsufficiency of Krüppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesis
    Amr M Ghaleb
    Division of Digestive Diseases, Department of Medicine, and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30033, USA
    Cancer Res 67:7147-54. 2007
    The zinc finger transcription factor Krüppel-like factor 4 (KLF4) is frequently down-regulated in colorectal cancer...
  5. pmc Opposing effects of Krüppel-like factor 4 (gut-enriched Krüppel-like factor) and Krüppel-like factor 5 (intestinal-enriched Krüppel-like factor) on the promoter of the Krüppel-like factor 4 gene
    Duyen T Dang
    Division of Gastroenterology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Nucleic Acids Res 30:2736-41. 2002
    b>KLF4 (Krüppel-like factor 4 or gut-enriched Krüppel-like factor, GKLF) and KLF5 (Krüppel-like factor 5 or intestinal-enriched Krüppel-like factor, IKLF) are two closely related members of the zinc finger-containing Krüppel-like ..
  6. pmc Overexpression of Krüppel-like factor 4 in the human colon cancer cell line RKO leads to reduced tumorigenecity
    Duyen T Dang
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Oncogene 22:3424-30. 2003
    Krüppel-like factor 4 (KLF4) is a zinc-finger-containing transcription factor, the expression of which is enriched in the postmitotic cells of the intestinal epithelium...
  7. ncbi Nuclear localization of KLF4 is associated with an aggressive phenotype in early-stage breast cancer
    Ashka Y Pandya
    Department of Cell Biology, University of Alabama at Birmingham, 35294, USA
    Clin Cancer Res 10:2709-19. 2004
    The Krüppel-like transcription factor KLF4/GKLF induces both malignant transformation and a slow-growth phenotype in vitro...
  8. pmc Putative tumor-suppressive function of Kruppel-like factor 4 in primary lung carcinoma
    Wenxian Hu
    Sir Run Run Shaw Hospital, Zhejiang University, Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, People s Republic of China
    Clin Cancer Res 15:5688-95. 2009
    Krüppel-like factor 4 (KLF4) is a zinc-finger protein that plays important roles in stem cells and the development of gastric cancers. However, the role of KLF4 in primary lung cancer is unknown...
  9. pmc Notch inhibits expression of the Krüppel-like factor 4 tumor suppressor in the intestinal epithelium
    Amr M Ghaleb
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
    Mol Cancer Res 6:1920-7. 2008
    The zinc finger-containing transcription factor, Krüppel-like factor 4 (KLF4), inhibits cell proliferation...
  10. pmc KLF4 is a novel candidate tumor suppressor gene in pancreatic ductal carcinoma
    Francesca Zammarchi
    Department of Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Am J Pathol 178:361-72. 2011
    ..Two genes, RSG3 and KLF4, mapped to 9q31.1 through 9q32, were further investigated...
  11. pmc Characterization of the structure and regulation of the murine gene encoding gut-enriched Krüppel-like factor (Krüppel-like factor 4)
    C S Mahatan
    Department of Medicine, The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Nucleic Acids Res 27:4562-9. 1999
    Gut-enriched Krüppel-like factor (GKLF, KLF4) is an epithelial-specific transcription factor whose expression is associated with growth arrest...
  12. ncbi The Kruppel-like KLF4 transcription factor, a novel regulator of urokinase receptor expression, drives synthesis of this binding site in colonic crypt luminal surface epithelial cells
    Heng Wang
    Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 279:22674-83. 2004
    ..sequences to the Kruppel-like family of transcription factors and showing partial homology with one of the members, KLF4. Like u-PAR, KLF4 expression is predominant in the luminal surface epithelial cells of the colonic crypt, and we ..
  13. doi Loss of nuclear expression of Krüppel-like factor 4 is associated with poor prognosis in patients with oral cancer
    Chih Jung Chen
    Institute of Medicine, Chung Shan Medical University, Taichuang, 402 Taiwan
    Hum Pathol 43:1119-25. 2012
    ..006) was an independent prognostic factor. Our results revealed that the loss of nuclear expression of Krüppel-like factor 4 is significantly associated with aggressive clinical manifestations and might be an adverse survival factor...
  14. doi Loss of cytoplasmic KLF4 expression is correlated with the progression and poor prognosis of nasopharyngeal carcinoma
    Zhen Liu
    Department of Pathology, Basic School of Guangzhou Medical University, Guangzhou, China Cancer Research Institute, Southern Medical University, Guangzhou, China
    Histopathology 63:362-70. 2013
    To examine, in nasopharyngeal carcinoma (NPC), the correlation of Krüppel-like factor 4 (KLF4) expression with clinicopathological features including patient prognosis.
  15. pmc Induction of KLF4 in basal keratinocytes blocks the proliferation-differentiation switch and initiates squamous epithelial dysplasia
    K Wade Foster
    Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Oncogene 24:1491-500. 2005
    b>KLF4/GKLF normally functions in differentiating epithelial cells, but also acts as a transforming oncogene in vitro...
  16. pmc Requirement of Krüppel-like factor 4 in preventing entry into mitosis following DNA damage
    Hong S Yoon
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 279:5035-41. 2004
    Previous studies indicate that Krüppel-like factor 4 (KLF4 or GKLF) controls the G1/S cell cycle checkpoint upon DNA damage...
  17. pmc Krüppel-like factor 4 prevents centrosome amplification following gamma-irradiation-induced DNA damage
    Hong S Yoon
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Oncogene 24:4017-25. 2005
    ..Here, we present evidence for the involvement of the mammalian Krüppel-like transcription factor, KLF4, in preventing centrosome amplification following DNA damage caused by gamma-irradiation...
  18. pmc Kruppel-like factor 4 (Klf4) prevents embryonic stem (ES) cell differentiation by regulating Nanog gene expression
    Peilin Zhang
    Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Biol Chem 285:9180-9. 2010
    Transcription factor Kruppel-like factor 4 (Klf4) is essential for somatic cell reprogramming. In addition, Klf4 seems to play a redundant role along with other Klf family proteins in embryonic stem (ES) cell self-renewal...
  19. pmc Expression of the tumor suppressor Krüppel-like factor 4 as a prognostic predictor for colon cancer
    Nilesh V Patel
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    Cancer Epidemiol Biomarkers Prev 19:2631-8. 2010
    The zinc finger transcription factor Krüppel-like factor 4 (KLF4) regulates numerous physiologic processes, including proliferation, differentiation, and development...
  20. ncbi Human EZF, a Krüppel-like zinc finger protein, is expressed in vascular endothelial cells and contains transcriptional activation and repression domains
    S F Yet
    Cardiovascular Biology Laboratory, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Biol Chem 273:1026-31. 1998
    ..Sequence analysis indicated that our clone, hEZF, is the human homologue of the recently reported mouse EZF and GKLF. hEZF is a single-copy gene that maps to chromosome 9q31...
  21. pmc Krüppel-like factor 4 exhibits antiapoptotic activity following gamma-radiation-induced DNA damage
    A M Ghaleb
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Oncogene 26:2365-73. 2007
    ..The zinc-finger-containing transcription factor, Krüppel-like factor 4 (KLF4), is a crucial mediator for the checkpoint functions of p53 after gamma-irradiation and does so by inhibiting the ..
  22. pmc Synergistic activation of the rat laminin gamma1 chain promoter by the gut-enriched Kruppel-like factor (GKLF/KLF4) and Sp1
    Yuji Higaki
    Department of Medicine, Box 356521, University of Washington, Seattle, WA 98195, USA
    Nucleic Acids Res 30:2270-9. 2002
    ..Using the bcn-1 element as a bait in the yeast one-hybrid screen, we cloned the gut-enriched Kruppel-like factor (GKLF or KLF4) from a rat mesangial cell library...
  23. pmc Identification and characterization of a gene encoding a gut-enriched Krüppel-like factor expressed during growth arrest
    J M Shields
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 271:20009-17. 1996
    A cDNA clone, named gut-enriched Krüppel-like factor (GKLF), was isolated from an NIH 3T3 library using a probe encoding the zinc finger region of the immediate-early transcription factor zif/268...
  24. ncbi A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells
    L A Garrett-Sinha
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 271:31384-90. 1996
    ..The chromosomal location of the gene was mapped using mouse interspecific backcrosses and was shown to localize to mouse chromosome 4 and to cosegregate with the thioredoxin gene...
  25. pmc Expression of the gut-enriched Krüppel-like factor gene during development and intestinal tumorigenesis
    H Ton-That
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    FEBS Lett 419:239-43. 1997
    We examined the expression of GKLF (gut-enriched Krüppel-like factor), a recently identified zinc finger-containing transcription factor, in mice during development using the ribonuclease protection assay...
  26. pmc Identification of the DNA sequence that interacts with the gut-enriched Krüppel-like factor
    J M Shields
    Department of Medicine and Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Nucleic Acids Res 26:796-802. 1998
    The gut-enriched Krüppel-like factor (GKLF) is a recently identified eukaryotic transcription factor that contains three C2H2zinc fingers...
  27. ncbi Oncogene expression cloning by retroviral transduction of adenovirus E1A-immortalized rat kidney RK3E cells: transformation of a host with epithelial features by c-MYC and the zinc finger protein GKLF
    K W Foster
    Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, 35294 3300, USA
    Cell Growth Differ 10:423-34. 1999
    ..in squamous cell carcinoma cell lines as c-MYC and the zinc finger protein gut-enriched Kruppel-like factor (GKLF)/epithelial zinc finger...
  28. ncbi Klf4 is a transcription factor required for establishing the barrier function of the skin
    J A Segre
    Howard Hughes Medical Institute, Department of Molecular Genetics and Cell Biology, The University of Chicago, Illinois 60637, USA
    Nat Genet 22:356-60. 1999
    ..We show here that Kruppel-like factor 4 (Klf4, encoded by the gene Klf4), highly expressed in the differentiating layers of epidermis, is both vital to and ..
  29. pmc The gut-enriched Kruppel-like factor (Kruppel-like factor 4) mediates the transactivating effect of p53 on the p21WAF1/Cip1 promoter
    W Zhang
    Departments of Medicine and Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 275:18391-8. 2000
    ..We show that the gene encoding the gut-enriched Krüppel-like factor (GKLF, KLF4) is concurrently induced with p21(WAF1/Cip1) during serum deprivation and DNA damage elicited by methyl ..
  30. pmc Expression of the gut-enriched Krüppel-like factor (Krüppel-like factor 4) gene in the human colon cancer cell line RKO is dependent on CDX2
    D T Dang
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, MD 21205, USA
    Oncogene 20:4884-90. 2001
    Gut-enriched Krüppel-like factor (GKLF or KLF4) is a zinc finger-containing, epithelial-specific transcription factor, that functions as a suppressor of cell proliferation...
  31. ncbi Gut-enriched Kruppel-like factor represses ornithine decarboxylase gene expression and functions as checkpoint regulator in colonic cancer cells
    Zhi Y Chen
    Section of Gastroenterology, Veterans Affairs Boston Healthcare System and Boston University School of Medicine, Boston, Massachusetts, 02118, USA
    J Biol Chem 277:46831-9. 2002
    Gut-enriched Krüppel-like factor (GKLF, KLF4) is an epithelial-specific transcription factor that expresses in the gastrointestinal tract and mediates growth arrest of colonic epithelium...
  32. pmc Kruppel-like factor 4 mediates p53-dependent G1/S cell cycle arrest in response to DNA damage
    Hong S Yoon
    Division of Digestive Diseases, Department of Medicine and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 278:2101-5. 2003
    ..Previous studies indicate that the Krüppel-like factor 4 (KLF4) gene is activated following DNA damage and that such activation depends on p53...
  33. pmc Down-regulation of gut-enriched Kruppel-like factor expression in esophageal cancer
    Nan Wang
    National Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences, Beijing 100021, China
    World J Gastroenterol 8:966-70. 2002
    ..But the molecular mechanisms of esophageal carcinoma remains unclear. Gut-enriched Kruppel-like factor (GKLF) is a newly identified transcription factor which is expressed abandantly in the epithelial cells of the ..
  34. pmc Transcriptional profiling of Krüppel-like factor 4 reveals a function in cell cycle regulation and epithelial differentiation
    Xinming Chen
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, 2101 Whitehead Research Building, Atlanta, GA 30322, USA
    J Mol Biol 326:665-77. 2003
    Krüppel-like factor 4 (KLF4) is an epithelially enriched, zinc finger-containing transcription factor, the expression of which is associated with growth arrest...
  35. ncbi Downregulation and growth inhibitory effect of epithelial-type Krüppel-like transcription factor KLF4, but not KLF5, in bladder cancer
    Shunsuke Ohnishi
    Genetics Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Biochem Biophys Res Commun 308:251-6. 2003
    ..Among the KLF family, the expression of KLF4 (GKLF) and KLF5 (IKLF) is highly restricted in the epithelial cells of several organs such as the gut and skin, and it ..
  36. ncbi Enterocyte differentiation marker intestinal alkaline phosphatase is a target gene of the gut-enriched Kruppel-like factor
    Brian F Hinnebusch
    Deptartment of Surgery, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    Am J Physiol Gastrointest Liver Physiol 286:G23-30. 2004
    We have examined the role that the transcription factor gut-enriched Krüppel-like factor (KLF4 or GKLF) plays in activating the enterocyte differentiation marker gene intestinal alkaline phosphatase (IAP)...
  37. ncbi Kruppel-like factor 4 (KLF4) represses histidine decarboxylase gene expression through an upstream Sp1 site and downstream gastrin responsive elements
    Wandong Ai
    Division of Gastroenterology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 279:8684-93. 2004
    ..Among eight positives from the one-hybrid screen, we identified Kruppel-like factor 4 (KLF4) (previously known as gut-enriched Kruppel-like factor (GKLF)) as one factor that binds to the gastrin responsive ..
  38. pmc Identification of Krüppel-like factor 4 as a potential tumor suppressor gene in colorectal cancer
    Weidong Zhao
    Department of Medicine, Division of Digestive Diseases, Emory University School of Medicine, Atlanta, GA 30322, USA
    Oncogene 23:395-402. 2004
    Krüppel-like factor 4 (KLF4 or GKLF) is an inhibitor of the cell cycle. The gene encoding KLF4 is localized on chromosome 9q, previously shown to exhibit allelic loss in colorectal cancer (CRC)...
  39. ncbi Krüppel-like factor 4 is transactivated by butyrate in colon cancer cells
    Zhi Yi Chen
    Section of Gastroenterology, VA Boston Healthcare System and Boston University School of Medicine, Boston, MA 02118, USA
    J Nutr 134:792-8. 2004
    ..The mediators of these effects remain poorly defined. Krüppel-like factor-4 (KLF4/GKLF) is a zinc-finger transcription factor that exhibits some physiologic properties similar to those of SCFA in the ..
  40. pmc Krüppel-like factors 4 and 5: the yin and yang regulators of cellular proliferation
    Amr M Ghaleb
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    Cell Res 15:92-6. 2005
    ..b>KLF4 and KLF5 are two closely related members of the KLF family that have a similar tissue distribution in embryos and ..
  41. ncbi Drastic down-regulation of Krüppel-like factor 4 expression is critical in human gastric cancer development and progression
    Daoyan Wei
    Department of Gastrointestinal Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 65:2746-54. 2005
    Krüppel-like factor 4 (KLF4) is highly expressed in epithelial tissues such as the gut and skin. However, the role of KLF4 in human gastric cancer development and progression is unknown...
  42. ncbi Single nucleotide polymorphisms in the gene encoding Krüppel-like factor 7 are associated with type 2 diabetes
    A Kanazawa
    Laboratory for Diabetic Nephropathy, SNP Research Centre, Institute of Physical and Chemical Research, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa, 230 0045, Japan
    Diabetologia 48:1315-22. 2005
    ..The present study aimed to examine the associations of single nucleotide polymorphisms (SNPs) in genes encoding members of the Krüppel-like-factor (KLF) family with type 2 diabetes in a large cohort of Japanese subjects...
  43. pmc Novel cross talk of Kruppel-like factor 4 and beta-catenin regulates normal intestinal homeostasis and tumor repression
    Wen Zhang
    Sealy Center for Cancer Cell Biology, University of Texas Medical Branch, Galveston, TX 77555 1048, USA
    Mol Cell Biol 26:2055-64. 2006
    ..Mutations in the Wnt pathway, however, are associated with colorectal cancers. Krüppel-like factor 4 (KLF4) is an epithelial transcriptional factor that is down-regulated in many colorectal cancers...
  44. ncbi Kruppel-like factor 4 regulates endothelial inflammation
    Anne Hamik
    Cardiovascular Research Institute, Case Western Reserve University, Cleveland, Ohio 44106 7290, USA
    J Biol Chem 282:13769-79. 2007
    ..These data implicate Kruppel-like factor 4 as a novel regulator of endothelial activation in response to pro-inflammatory stimuli...
  45. pmc The diverse functions of Krüppel-like factors 4 and 5 in epithelial biology and pathobiology
    Beth B McConnell
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
    Bioessays 29:549-57. 2007
    ..b>KLF4 and KLF5 are two closely related members of this family and are both highly expressed in epithelial tissues...
  46. ncbi Genetic and epigenetic analysis of the KLF4 gene in gastric cancer
    Yong Gu Cho
    Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea
    APMIS 115:802-8. 2007
    b>KLF4, which is also known as the gut-enriched Kruppel-like factor, plays important roles during the proliferation and differentiation of gastrointestinal epithelial cells...
  47. ncbi Kruppel-like factor 4 is acetylated by p300 and regulates gene transcription via modulation of histone acetylation
    Paul M Evans
    Department of Biochemistry and Molecular Biology, Sealy Center for Cancer Cell Biology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, USA
    J Biol Chem 282:33994-4002. 2007
    Colon cancer is the second leading cause of cancer death in the United States. Krüppel-like factor 4 (KLF4) is a transcription factor involved in both proliferation and differentiation in the colon...
  48. ncbi Reprogramming of human somatic cells to pluripotency with defined factors
    In Hyun Park
    Division of Pediatric Hematology Oncology, Children s Hospital Boston and Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nature 451:141-6. 2008
    ..have been reprogrammed directly to pluripotency by ectopic expression of four transcription factors (Oct4, Sox2, Klf4 and Myc) to yield induced pluripotent stem (iPS) cells...
  49. doi Dynamic down-regulation of Krüppel-like factor 4 in colorectal adenoma-carcinoma sequence
    Jing Xu
    Department of Pathology, School of Medicine, Zhejiang University, Hangzhou, 310058, People s Republic of China
    J Cancer Res Clin Oncol 134:891-8. 2008
    To explore the clinical significance of Krüppel-like factors 4 (KLF4) expression in colorectal cancer initiation and progression.
  50. ncbi Nuclear Krüppel-like factor 4 expression is associated with human skin squamous cell carcinoma progression and metastasis
    Yi Ju Chen
    Department of Dermatology, Taichung Veterans General Hospital, Taiwan
    Cancer Biol Ther 7:777-82. 2008
    Krüppel-like factor 4 (KLF4) is a transcription factor regulating cell growth and differentiation...
  51. pmc KLF4 regulation in intestinal epithelial cell maturation
    M Flandez
    Department of Oncology, Albert Einstein Cancer Center, Montefiore Medical Center, 111 East 210th St Bronx, NY 10467, USA
    Exp Cell Res 314:3712-23. 2008
    The Krüppel-like factor 4 (KLF4) transcription factor suppresses tumorigenesis in gastrointestinal epithelium. Thus, its expression is decreased in gastric and colon cancers...
  52. doi Krüppel-like factor 4 represses transcription of the survivin gene in esophageal cancer cell lines
    Guo Zhang
    Laboratory of Cell and Molecular Biology, National Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences, Beijing 100021, PR China
    Biol Chem 390:463-9. 2009
    ..In this study, we demonstrate that there are six putative binding sites of Krüppel-like factor 4 (KLF4) within the 2000-bp region upstream of the transcription start site of the human survivin gene...
  53. doi MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells
    Na Xu
    Neuroscience Research Institute, Department of Molecular, Cellular, and Developmental Biology, The University of California, Santa Barbara, Santa Barbara, CA 93106, USA
    Cell 137:647-58. 2009
    ..We identify the pluripotency factors OCT4, SOX2, and KLF4 as direct targets of miR-145 and show that endogenous miR-145 represses the 3' untranslated regions of OCT4, SOX2, ..
  54. doi All-trans retinoic acid increases KLF4 acetylation by inducing HDAC2 phosphorylation and its dissociation from KLF4 in vascular smooth muscle cells
    Fang Meng
    Department of Biochemistry and Molecular Biology, Hebei Medical University, Shijiazhuang, PR China
    Biochem Biophys Res Commun 387:13-8. 2009
    The zinc finger transcription factor Krüppel-like factor 4 (KLF4) has been implicated in vascular smooth muscle cell differentiation induced by all-trans retinoic acid (ATRA)...
  55. doi KLF4 suppresses estrogen-dependent breast cancer growth by inhibiting the transcriptional activity of ERalpha
    K Akaogi
    Graduate School of Life and Environmental Sciences, University of Tsukuba, Ibaraki, Japan
    Oncogene 28:2894-902. 2009
    Kruppel-like factor 4 (KLF4) is a transcription factor that participates in both tumor suppression and oncogenesis...
  56. doi KLF4 suppresses HDACi induced caspase activation and the SAPK pathway by targeting p57(Kip2)
    Nung Ky
    Nanyang Technological University, Singapore, Singapore
    Apoptosis 14:1095-107. 2009
    Kruppel-like factor 4 (KLF4) belongs to a family of evolutionarily conserved zinc finger-containing transcription factors...
  57. pmc Epithelial transformation by KLF4 requires Notch1 but not canonical Notch1 signaling
    Zhaoli Liu
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL, USA
    Cancer Biol Ther 8:1840-51. 2009
    The transcription factors Notch1 and KLF4 specify epithelial cell fates and confer stem cell properties...
  58. pmc Defining the regulation of KLF4 expression and its downstream transcriptional targets in vascular endothelial cells
    Guadalupe Villarreal
    Laboratory for Systems Biology, Center for Excellence in Vascular Biology, Department of Pathology, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    Biochem Biophys Res Commun 391:984-9. 2010
    The Kruppel-like factor 2 (KLF2) and Kruppel-like factor 4 (KLF4) transcription factors have recently been shown to act as critical regulators of endothelial homeostasis...
  59. pmc Genetic and epigenetic inactivation of Kruppel-like factor 4 in medulloblastoma
    Yukiko Nakahara
    Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, Toronto, Ontario, Canada
    Neoplasia 12:20-7. 2010
    ..We have identified rare, recurrent homozygous deletions of Kruppel-like Factor 4 (KLF4) in medulloblastoma using high-resolution single nucleotide polymorphism arrays, digital karyotyping, and genomic ..
  60. pmc KLF4 inhibition of lung cancer cell invasion by suppression of SPARC expression
    Yanbin Zhou
    Department of Pulmonary Medicine, First Affiliated Hospital of Sun Yat sen University, Guangzhou, China
    Cancer Biol Ther 9:507-13. 2010
    Krüppel-Like Factor 4 (KLF4) functions as a tumor suppressor in some cancers, but its molecular mechanism is not clear. Our recent study also showed that the expression of KLF4 is dramatically reduced in primary lung cancer tissues...
  61. pmc Kruppel-like factor 4 inhibits epithelial-to-mesenchymal transition through regulation of E-cadherin gene expression
    Jennifer L Yori
    Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 285:16854-63. 2010
    The Krüppel-like factor 4 (KLF4) is a transcriptional regulator of proliferation and differentiation in epithelial cells, both during development and tumorigenesis...
  62. pmc Differential control of Notch1 gene transcription by Klf4 and Sp3 transcription factors in normal versus cancer-derived keratinocytes
    Chiara Lambertini
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    PLoS ONE 5:e10369. 2010
    ..This GC rich region lacks p53 binding sites, but binds Klf4 and Sp3...
  63. pmc KLF4α up-regulation promotes cell cycle progression and reduces survival time of patients with pancreatic cancer
    Daoyan Wei
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Gastroenterology 139:2135-45. 2010
    Krüppel-like factor 4 (KLF4) is a transcription factor associated with tumor suppression and oncogenesis...
  64. doi Gene profiling of bone marrow- and adipose tissue-derived stromal cells: a key role of Kruppel-like factor 4 in cell fate regulation
    Nathalie Saulnier
    Department of Internal Medicine and Gastroenterology, Gemelli University Hospital, Catholic University of Sacred Heart, Rome, Italy
    Cytotherapy 13:329-40. 2011
    ..The aim of this study was to compare the genome-wide expression profiles of bone marrow-and adipose tissue-derived MSC, in order to identify a common molecular stemness core...
  65. pmc Prognostic value and function of KLF4 in prostate cancer: RNAa and vector-mediated overexpression identify KLF4 as an inhibitor of tumor cell growth and migration
    Ji Wang
    Department of Urology and Helen Diller Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California, USA
    Cancer Res 70:10182-91. 2010
    b>KLF4/GLKF4 is a transcription factor that can have divergent functions in different malignancies. The role of KLF4 in prostate cancer etiology remains unclear...
  66. doi Persistent Krüppel-like factor 4 expression predicts progression and poor prognosis of head and neck squamous cell carcinoma
    Shyh Kuan Tai
    Department of Otolaryngology, Taipei Veterans General Hospital, Taipei, Taiwan
    Cancer Sci 102:895-902. 2011
    ..No molecular markers are presently used for predicting prognosis in HNSCC. Krüppel-like factor 4 (KLF4) is a transcription factor with diverse physiological functions, and possesses opposing roles in different human ..
  67. pmc Kruppel-like factor 4 (KLF4) is required for maintenance of breast cancer stem cells and for cell migration and invasion
    F Yu
    Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, SC, USA
    Oncogene 30:2161-72. 2011
    Kruppel-like factor 4 (KLF4) is highly expressed in more than 70% of breast cancers and functions as an oncogene. However, an exact mechanism by which KLF4 enhances tumorigenesis of breast cancer remains unknown...
  68. doi Oxidized phosphatidylcholine induces migration of bone marrow-derived mesenchymal stem cells through Krüppel-like factor 4-dependent mechanism
    Sang Hun Shin
    Medical Research Center for Ischemic Tissue Regeneration, Pusan National University, Gyeongsangnam do, Yangsan, Republic of Korea
    Mol Cell Biochem 352:109-15. 2011
    ..Both PAF and POVPC induced expression of Krüppel-like factor 4 (KLF4) in hBMSCs...
  69. pmc KLF4-mediated negative regulation of IFITM3 expression plays a critical role in colon cancer pathogenesis
    Dawei Li
    Departments of General Surgery and Pathology, Shanghai Jiaotong University Affiliated First People s Hospital, Shanghai, PR China
    Clin Cancer Res 17:3558-68. 2011
    ..In this study, we sought to determine the clinical significance and underlying mechanisms of its dysregulated expression in human colon tumor specimens and murine models of this disease...
  70. pmc down-regulation of Kruppel-like factor-4 (KLF4) by microRNA-143/145 is critical for modulation of vascular smooth muscle cell phenotype by transforming growth factor-beta and bone morphogenetic protein 4
    Brandi N Davis-Dusenbery
    Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Biol Chem 286:28097-110. 2011
    ..Krüppel-like factor-4 (KLF4) is known to inhibit activation of the CArG box...
  71. pmc Regulation of the potential marker for intestinal cells, Bmi1, by β-catenin and the zinc finger protein KLF4: implications for colon cancer
    Tianxin Yu
    Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky 40506, USA
    J Biol Chem 287:3760-8. 2012
    ..Krüppel-like factor 4 (KLF4) is a zinc finger protein highly expressed in the gut and skin...
  72. doi Krüppel-like factor 4 functions as a tumor suppressor in cervical carcinoma
    Wen Ting Yang
    Department of Reproductive Medicine, First Affiliated Hospital, Xi an Jiaotong University of Medical School, Xi an, People s Republic of China
    Cancer 118:3691-702. 2012
    The Krüppel-like factor 4 (KLF4) protein, a zinc finger transcription factor that is highly expressed in epithelial tissues such as the gut and skin, has been implicated in both tumor suppression and progression...
  73. pmc Site-specific microRNA-92a regulation of Kruppel-like factors 4 and 2 in atherosusceptible endothelium
    Yun Fang
    Institute for Medicine and Engineering, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA
    Arterioscler Thromb Vasc Biol 32:979-87. 2012
    Endothelial transcription factors Krüppel-like factor 4 (KLF4) and KLF2 are implicated in protection against atherogenesis...
  74. pmc Regulation of KLF4 turnover reveals an unexpected tissue-specific role of pVHL in tumorigenesis
    Armin M Gamper
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Mol Cell 45:233-43. 2012
    The transcription factor Krüppel-like factor 4 (KLF4) is an important regulator of cell-fate decision, including cell-cycle regulation, apoptosis, and stem cell renewal, and plays an ambivalent role in tumorigenesis as a tissue-specific ..
  75. pmc ZNF750 is a p63 target gene that induces KLF4 to drive terminal epidermal differentiation
    George L Sen
    Department of Medicine Cellular and Molecular Medicine, University of California San Diego School of Medicine, La Jolla, CA 92093, USA
    Dev Cell 22:669-77. 2012
    ..A search for functionally important ZNF750 targets via analysis of ZNF750-regulated genes identified KLF4, a transcription factor that activates late epidermal differentiation...
  76. doi Krüppel-like factor 4 negatively regulates β-catenin expression and inhibits the proliferation, invasion and metastasis of gastric cancer
    Neng Zhang
    Department of General Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P R China
    Int J Oncol 40:2038-48. 2012
    Krüppel-like factor 4 (KLF4) is a zinc-finger protein that plays an important role in the progression of gastric carcinoma...
  77. pmc Deficiency of the Kruppel-like factor KLF4 correlates with increased cell proliferation and enhanced skin tumorigenesis
    Juan Li
    Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, 29208, USA
    Carcinogenesis 33:1239-46. 2012
    Kruppel-like factor 4 (KLF4) is a transcription factor that is highly expressed in differentiated epithelial cells including that of the skin. It is critical for specification or function of differentiated epithelial cells...
  78. doi KLF4 translation level is associated with differentiation stage of different pediatric leukemias in both cell lines and primary samples
    Xiaoping Guo
    Division of Hematology Oncology, Zhejiang Key Laboratory for Neonatal Diseases, Children s Hospital of Zhejiang University School of Medicine, 57 Zhuganxiang Road, Yan an Street, Hangzhou, 310003, People s Republic of China
    Clin Exp Med 13:99-107. 2013
    Biomarkers on malignant cells may confer prognostic significance. Krüppel-like factor 4 (KLF4) has been reported to be expressed variably on leukemia cells, but its expression patterns in leukemias with different differentiation stages ..
  79. pmc Dysregulated Krüppel-like factor 4 and vitamin D receptor signaling contribute to progression of hepatocellular carcinoma
    Qi Li
    Tumor Institute, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, People s Republic of China
    Gastroenterology 143:799-810.e1-2. 2012
    Krüppel-like factor 4 (KLF4) is a transcription factor and putative tumor suppressor. However, little is known about its effects in hepatocellular carcinogenesis...
  80. doi Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells
    Katrin Hoffmeyer
    Department of Molecular Embryology, Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany
    Science 336:1549-54. 2012
    ..We show that β-catenin regulates Tert expression through the interaction with Klf4, a core component of the pluripotency transcriptional network...
  81. doi Klf4 transcription factor is expressed in the cytoplasm of prostate cancer cells
    Clémentine Le Magnen
    Institute for Surgical Research and Hospital Management, Department of Biomedicine, Basel University Hospital, Basel, Switzerland
    Eur J Cancer 49:955-63. 2013
    ..Here we comparatively addressed the expression of genes encoding putative stemness regulators including c-Myc, Klf4, Nanog, Oct4A and Sox2 genes in benign prostatic hyperplasia (BPH) and prostate cancer (PCA).
  82. pmc Krüppel-like factor 4 acts as an oncogene in colon cancer stem cell-enriched spheroid cells
    Zhengwei Leng
    Department of General Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People s Republic of China
    PLoS ONE 8:e56082. 2013
    ..Krüppel-like factor 4 (KLF4) is essential factor for maintaining self-renewal of adult and embryonic stem cells...
  83. doi Epigenetic alterations of Krüppel-like factor 4 and its tumor suppressor function in renal cell carcinoma
    Heng Li
    Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Carcinogenesis 34:2262-70. 2013
    Krüppel-like factor 4 (KLF4) is a transcription factor that can have divergent functions in different malignancies. The expression and role of KLF4 in renal cell cancer remain unclear...
  84. ncbi KLF4, p21 and context-dependent opposing forces in cancer
    Benjamin D Rowland
    Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Nat Rev Cancer 6:11-23. 2006
    ..Recent studies have shown that one family member, KLF4, can function both as a tumour suppressor and an oncogene...
  85. pmc Sequence of the 5'-flanking region and promoter activity of the human mucin gene MUC5B in different phenotypes of colon cancer cells
    I Van Seuningen
    Unite INSERM 377, Place de Verdun, 59045 Lille Cedex, France
    Biochem J 348:675-86. 2000
    ..protein (CREB)-, hepatocyte nuclear factor (HNF)-1-, HNF-3-, TGT3-, gut-enriched Krüppel factor (GKLF)-, thyroid transcription factor (TTF)-1- and glucocorticoid receptor element (GRE)-binding sites...
  86. doi Differences in goblet cell differentiation between Crohn's disease and ulcerative colitis
    Michael Gersemann
    Department of Internal Medicine I, Robert Bosch Hospital, Stuttgart, Germany
    Differentiation 77:84-94. 2009
    ..experimental animals, colonic goblet cell differentiation is regulated by interacting transcription factors Hath1, KLF4 and the Notch, as well as Wnt pathways, whereas data in humans are limited...
  87. pmc Histone deacetylase inhibitors stimulate histone H3 lysine 4 methylation in part via transcriptional repression of histone H3 lysine 4 demethylases
    Po Hsien Huang
    Division of Medicinal Chemistry, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA
    Mol Pharmacol 79:197-206. 2011
    ..the H3K4 demethylase RBP2 at the promoter of genes associated with tumor suppression and differentiation, including KLF4 and E-cadherin...
  88. doi Epidermal neural crest stem cells (EPI-NCSC) and pluripotency
    Maya Sieber-Blum
    Institute of Human Genetics and North East England Stem Cell Institute, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne NE13BZ, UK
    Stem Cell Rev 4:256-60. 2008
    ..Here we have corroborated this notion by real-time PCR. Our results show similarities in the expression of Myc, Klf4, Sox2 and Lin28 genes between EPI-NCSC and embryonic stem cells (ESC)...
  89. doi Multipotential ability of primitive germ cells from neonatal pig testis cultured in vitro
    Sandeep Goel
    Laboratory of Reproductive Biology, Graduate School of Agriculture, Kyoto University, Kyoto 606 8502, Japan
    Reprod Fertil Dev 21:696-708. 2009
    ..the expression of these transcription factors, as well as other vital transcription factors, such as NANOG, KLF4 and DAZL, were markedly upregulated in cultured cells...
  90. doi KLF4 promotes the expression, translocation, and releas eof HMGB1 in RAW264.7 macrophages in response to LPS
    Junwen Liu
    Laboratory of Shock, Department of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, People s Republic of China
    Shock 30:260-6. 2008
    Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing transcription factor with diverse regulatory functions in cell growth, proliferation, differentiation, and embryogenesis...
  91. doi Generation of human induced pluripotent stem cells from a Bombay individual: moving towards "universal-donor" red blood cells
    Ali Seifinejad
    Department of Stem Cells and Developmental Biology, Royan Institute for Stem Cell Biology and Technology, PO Box 19395 4644, ACECR, Tehran, Iran
    Biochem Biophys Res Commun 391:329-34. 2010
    ..dermal fibroblasts of a Bombay blood-type individual by the ectopic expression of established transcription factors Klf4, Oct4, Sox2, and c-Myc...
  92. ncbi The mouse Krüppel-like Factor 4 (Klf4) gene: four functional polyadenylation sites which are used in a cell-specific manner as revealed by testicular transcript analysis and multiple processed pseudogenes
    Maren Godmann
    Institute of Anatomy, Developmental Biology, Hufelandstrasse 55, University of Duisburg Essen Medical School, 45122 Essen, Germany
    Gene 361:149-56. 2005
    The transcription factor Krüppel-like factor 4 (Klf4) is involved in cell cycle arrest and terminal differentiation of many epithelial cell types...
  93. pmc Krüppel-like factor 4 regulates adaptive expression of the zinc transporter Zip4 in mouse small intestine
    Juan P Liuzzi
    Center for Nutritional Sciences and Food Science and Human Nutrition Department, University of Florida, Gainesville, FL 32611, USA
    Am J Physiol Gastrointest Liver Physiol 296:G517-23. 2009
    ..With the present experiments, we show that the zinc finger transcription factor Krüppel-like factor 4 (KLF4), produced in high abundance in the intestine, is expressed at elevated levels in mice fed a low-zinc diet...
  94. pmc Adult palatum as a novel source of neural crest-related stem cells
    Darius Widera
    Institute of Cell Biology, Faculty of Biology, University of Bielefeld, Bielefeld, Germany
    Stem Cells 27:1899-910. 2009
    ..to the expression of neural crest stem cell markers such as Nestin, Sox2, and p75, we detected the expression of Klf4, Oct4, and c-Myc. pNC-SCs differentiated efficiently into neuronal and glial cells...
  95. pmc Regeneration and reprogramming compared
    Bea Christen
    Center for Regenerative Medicine of Barcelona, 08003 Barcelona, Spain
    BMC Biol 8:5. 2010
    ..Dedifferentiation also occurs in the induction of pluripotent stem cells when a set of transcription factors (Oct4, Sox2, Klf4 and c-Myc) is over expressed in mature cell types.
  96. pmc Platelet factor 4 regulation of monocyte KLF4 in experimental cerebral malaria
    Kalyan Srivastava
    Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America
    PLoS ONE 5:e10413. 2010
    ..We now show that PF4 drives monocyte cytokine production in a Kruppel like factor 4 (KLF4) dependent manner...
  97. doi Generation of human-induced pluripotent stem cells from gut mesentery-derived cells by ectopic expression of OCT4/SOX2/NANOG
    Yang Li
    Peking University Stem Cell Research Center, Beijing, People s Republic of China
    Cell Reprogram 12:237-47. 2010
    ..However, traditional methods of reprogramming in human somatic cells involve the use of oncogenes c-MYC and KLF4, which are not applicable to clinical translation...
  98. pmc Gene function in early mouse embryonic stem cell differentiation
    Kagnew Hailesellasse Sene
    Ontario Genomics Innovation Centre, Ottawa Health Research Institute, Ottawa, ON, Canada
    BMC Genomics 8:85. 2007
    ..5) undergoing undirected differentiation into embryoid bodies (EBs) over a period of two weeks...
  99. ncbi Cell growth inhibition by okadaic acid involves gut-enriched Kruppel-like factor mediated enhanced expression of c-Myc
    Liyue Zhang
    John D Dingell V A Medical Center and Department of Internal Medicine, Wayne State University, Detroit, Michigan 48201, USA
    Cancer Res 67:10198-206. 2007
    ..Database search revealed presence of a consensus sequence for zinc finger protein gut-enriched Kruppel-like factor (GKLF) in OA-responsive region of the c-myc promoter...
  100. ncbi Identification of signaling pathways in macrophage exposed to Porphyromonas gingivalis or to its purified cell wall components
    Qingde Zhou
    Department of Periodontology and Oral Biology, School of Dental Medicine, Boston University, Boston, MA 02118, USA
    J Immunol 179:7777-90. 2007
    ..four putative transcriptional regulation models that associate with transcription factors NFkappaB, IRF7, and KLF4. Using gene knockout mice and siRNA to silence mouse genes, we showed that both TLR2 and TLR7 are essential for the ..
  101. pmc Novel sequential ChIP and simplified basic ChIP protocols for promoter co-occupancy and target gene identification in human embryonic stem cells
    Ricardo B Medeiros
    Dept, Antibody Applications and Stem Cells, R and D Systems, Inc, Minneapolis MN, USA
    BMC Biotechnol 9:59. 2009
    ..Advances in this field will greatly benefit from the development and use of simple, fast, sensitive and straightforward ChIP assay and analysis methodologies...

Research Grants66

  1. TSHR and thyrocyte development
    Reigh Yi Lin; Fiscal Year: 2013
    ..ES cell-like state using the retrovirus-mediated transfection of four transcription factors (Oct4, Sox2, c-Myc, and Klf4)...
  2. Generation of Human iPS Cells via Non-integrating Vectors
    Wen Shu Wu; Fiscal Year: 2010
    ..stem (iPS) cells by reprogramming of somatic cells via the defined transcription factors (Oct3/4 and Sox2 with Klf4 and c-Myc or Nanog and Lin28)...
  3. Function of KLF4-expressing stem cells in mouse cutaneous wound healing
    Walden Ai; Fiscal Year: 2013
    ..of our laboratory is to examine the expression and function of a nuclear protein, named Kruppel-like factor 4 (KLF4), in tissue stem cells...
  4. Cardiovascular and Therapeutic Potential of Reprogrammed Human Fibroblasts
    WILLIAM ROBB MACLELLAN; Fiscal Year: 2010
    ..factor 1 (Oct3/4), SRY-box containing gene 2 (Sox2), proto-oncogene myc (c-Myc), and Kruppel-like factor 4 (Klf4) led to the generation of induced pluripotent stem (iPS) cells that exhibited morphology and growth properties ..
  5. Role of Kruppel-Like Factor 4 in Wnt and Notch Signaling in the Intestinal Tract
    Amr Ghaleb; Fiscal Year: 2010
    ..Kr[unreadable]ppel-like factor 4 [KLF4;also called gut-enriched Kr[unreadable]ppel-like factor (GKLF)] was previously identified by our group as a zinc finger-containing transcription factor expressed in the ..
  6. Aging and Reprogramming of Somatic Cells to Pluripotency
    Peter J Hornsby; Fiscal Year: 2010
    ..This will be tested by the retroviral introduction of reprogramming genes (Oct4, Sox2, Klf4, with or without c-Myc) into skin fibroblasts from marmosets of a range of ages, newborn to very old (~13 years)...
  7. Role of miR-145 in Vascular Smooth Muscle Cell BiologyRole of
    Chunxiang Zhang; Fiscal Year: 2013
    ..and atherosclerotic lesion formation via its target genes, kruppel-like factor 5 (KLF5) and kruppel-like factor 4 (KLF4). Our hypothesis is supported by our preliminary studies...
  8. Mana M Parast; Fiscal Year: 2014
    ..fibroblast from these molar placentas and reprogram them into iPS cells using lenti- or Sendai virus expressing Klf4, Sox2, Oct4, and c-Myc...
  9. Ming Ming Zhou; Fiscal Year: 2014
    ..reprogramming of somatic cells to induced pluripotent stem cells using four transcription factors Oct3/4, Sox2, Klf4 and c-Myc (OSKM) highlights the ultimate control of cell fate by gene transcription...
  10. Nuclear Reprogramming and Phenotype in Cloned Embryos
    Keith E Latham; Fiscal Year: 2013
    ..In Aim 2, we will manipulate the expression and activities of two TFs (KLF4, CBX4) in cloned embryos and monitor effects on gene expression in order to test this hypothesis...
  11. Recapitulating developmental pathways to improve iPSC-RPE derivation protocols
    PETER DWAYNE WESTENSKOW; Fiscal Year: 2013
    ..We have derived RPE from hESCs and iPSCs induced to pluripotency using all 4 Thomson factors and with only two (Klf4 and Oct4) and biomicking small molecules...
  12. Vincent W Yang; Fiscal Year: 2016
    ..group previously identified a zinc finger- containing transcription factor called Kr[unreadable]ppel-like factor 4 (KLF4;also named gut-enriched Kr[unreadable]ppel-like factor or GKLF), the expression of which is enriched in the ..
  13. Role of OCT4 in reprogramming human skin keratinocytes
    Jackie R Bickenbach; Fiscal Year: 2012
    ..with a retroviral vector carrying a cocktail of two embryonic genes, Oct4 and Sox2, and two cancer genes, Klf4 and c-myc...
  14. A Myc-centered network in embryonic stem cells and somatic cell reprogramming
    Jonghwan Kim; Fiscal Year: 2013
    ..Myc is one of the four transcription factors (Oct4, Sox2, Klf4, and Myc) used in generation of IPS cells and is a protein of interest due to its dual roles in the reprogramming ..
  15. Neurons from pluripotent stem cells derived from schizophrenia patient fibroblast
    Russell L Margolis; Fiscal Year: 2010
    ..will generate fibroblast cell lines form the skin biopsies, and then use retroviruses containing human Oc3/4, Sox2, Klf4, and c-Myc to generate pluripotent stem cells from the fibroblasts...
  16. Generation of pluripotent cells by reprogramming of the somatic epigenome.
    GORDON GRANT WELSTEAD; Fiscal Year: 2010
    ..The recent discovery that four transcription factors: Oct4, Sox2, c-Myc and Klf4, can reprogram somatic fibroblasts into an embryonic-like pluripotent state has provided a potential alternative to ..
  17. Generation of hPSCs Using Reprogramming Proteins-Encapsulated Nanoparticles
    Hsian Rong Tseng; Fiscal Year: 2012
    ..These NPs are capable of delivering reprogramming transcription factors (TFs), namely OCT4, SOX2, KLF4 and c-MYC...
  18. Optimal Generation and Characterization of iPS Cell Lines from Healthy and ADHD S
    Kwang Soo Kim; Fiscal Year: 2010
    ..e., Oct4, Sox2, Klf4 and c-Myc)...
  19. Optimal Generation and Characterization of iPS Cell Lines from Healthy and ADHD S
    Kwang Soo Kim; Fiscal Year: 2012
    ..e., Oct4, Sox2, Klf4 and c-Myc)...
  20. ROBERT MICHAEL ROBERTS; Fiscal Year: 2016
    ..additional lines of LIF-dependent ICM-derived porcine (p) iPSC (pICM-iPSC) by upregulating human POU5F1 and KLF4 transgenes assembled on "tet-on" bicistronic lentiviral vectors, which offer the advantage of effective transgene ..
  21. TNF-a and vascular smooth muscle cell phenotypic modulation in cerebral aneurysms
    Aaron S Dumont; Fiscal Year: 2013
    ..in the development and progression of cerebral aneurysms in vivo by focusing on the critical transcription factor, KLF4. This work will have direct translational applications to stroke, which lingers as the third leading cause of ..
  22. David L Spector; Fiscal Year: 2016
    ..The nuclear position of a series of 4 genes encoding the transcription factors Oct4, Nanog, Sox2, and Klf4 will be examined, as transcriptional silencing of these genes serves as a trigger for the initiation of the ..
  23. Development of a cell replacement therapy to treat retinal degenerative blindness
    BUDD ALBERT TUCKER; Fiscal Year: 2010
    ..via genetic reprogramming of dermal fibroblasts to pluripotency using the 4 transcription factors Oct4, Sox2, KLF4, and c-Myc, is of interest...
  24. Small molecules that induce/promote generation of iPS cells
    Sheng Ding; Fiscal Year: 2010
    ..e. Oct4, cMyc, Sox2 and Klf4) together [5]...
  25. ELAINE LYNETTE WILSON; Fiscal Year: 2016
    ..Of 6 genes we found to be uniquely over expressed in APSCs, two transcription factors, KLF4 and JUNB, and an enzyme, peptidylarginine deiminase type IV (PADI4), all with previously suggested context-..
  26. Jeffrey H Kordower; Fiscal Year: 2016
    ..e., Oct4, Sox2, Klf4 and c-Myc)(Takahashi and Yamanaka, 2006)...
  27. MicroRNAs in small intestinal epithelial cell proliferation and differentiation
    ANNE MATHEA HUTSON; Fiscal Year: 2012
    ..Also, I found that the crypt-enriched miR-152 is predicted to target Klf4, a transcription factor expressed in differentiated intestinal epithelial cells...
  28. Eva Hernando; Fiscal Year: 2016
    ..Furthermore, our preliminary studies indicate that histone acetylation and Krupple-like factor-4 (KLF4), a canonical pluripotency transcription factor, govern miR-183-96-182 expression in both hESCs and melanoma cells...
  29. SHIVALINGAPPA KOTTUR SWAMYNATHAN; Fiscal Year: 2016
    ..Simplex Virus type-1 (HSV-1) infection concurrent with neutrophil infiltration, (iii) decreased in the inflamed Klf4-conditional null (Klf4CN) corneas, and (iv) suppressed by pro-inflammatory interleukins IL-4 and IL-13...
  30. Jordan S Pober; Fiscal Year: 2015
    ..of proteins that directly form TJs or that control TJ organization through the actin cytoskeleton;and (c) that KLF4, a transcription factor induced in capillary ECs by laminar shear stress, can regulate the pathological effects of ..
  31. A novel protein transduction method to generate induced pluripotent stem cells wi
    JAMES FREDERICK ELIASON; Fiscal Year: 2010
    ..The initial methods for reprogramming focused on delivery of four genes (Oct4, Sox2, and either Klf4 plus c-Myc, or NANOG plus Lin 28) using genetic transduction methods that potentially can create mutations and/or ..
  32. KLF4 , the endothelium, and vascular inflammation
    MUKESH KUMAR JAIN; Fiscal Year: 2013
    ..b>KLF4 is a member of the Kruppel-like family of zinc-finger transcription factors that regulate critical processes such ..
  33. MUKESH KUMAR JAIN; Fiscal Year: 2014
    ..Although previous studies by our group and others implicated KLF4 in myeloid cell biology, the in vivo physiological relevance has not been elucidated...
  34. Role of KLF4 and KLF5 in mouse cornea development
    SHIVALINGAPPA KOTTUR SWAMYNATHAN; Fiscal Year: 2010
    This research proposal aims at understanding the role of Kruppel-like zinc-finger transcription factors KLF4 and KLF5, two of the most abundant transcription factors in the mouse cornea, in regulating the normal development and ..
  35. Development of Pluripotent Amniotic Stem Cell Banks for Disease Modeling
    JAMES FREDERICK ELIASON; Fiscal Year: 2011
    ..applicant): Direct reprogramming of somatic cells with the transcription factors Oct4 (also called Pou5f1), Sox2, Klf4 and Myc1 yields induced Pluripotent Stem (iPS) cells with marked similarity to Embryonic Stem (ES) cells...
  36. Hedgehog Signaling in the Adventitia
    Mark W Majesky; Fiscal Year: 2012
    ..SMCs, however, AdvSca1 cells express potent co-repressors of SRF-dependent transcription in vivo including Msx1 and KLF4 that may play key roles in maintaining SMC progenitors in the vessel wall...
  37. Mouse Genes that Regulate Hemostasis and/or Thrombosis
    Thomas J Kunicki; Fiscal Year: 2011
    ..Having obtained preliminary data that one of the candidate genes may be Klf4, the gene for Kruppel-like Factor 4, I have designed a strategy to evaluate in vivo the relevance of endothelial ..
  38. Michael F Carey; Fiscal Year: 2016
    ..in both our model GAL4-VP16 in vitro system and on natural stem cell promoters controlled by Sox2, Oct4, Myc, Klf4 and Nanog...
  39. A Myc-centered network in embryonic stem cells and somatic cell reprogramming
    Jonghwan Kim; Fiscal Year: 2010
    ..Myc is one of the four transcription factors (Oct4, Sox2, Klf4, and Myc) used in generation of iPS cells and Is a protein of interest due to its dual roles In the reprogramming ..
  40. MARY CM WEISER-EVANS; Fiscal Year: 2014
    ..g. microenvironmental reprogramming);reprogramming is dependent on induction on the transcription factor, Klf4. After vascular injury, recruitment of these cells contributes to neointima formation...
  41. Sheng Ding; Fiscal Year: 2014
    ..g. Oct4, cMyc, Sox2 and Klf4)...
  42. MELVIN EDWARD MEDOF; Fiscal Year: 2015
    ..inhibitor DAF, and our studies show that DAF expression is controlled transcriptionally by Kruppel-like factor 4 (KLF4)...
  43. KLF4, Monocyte Biology and Vasculary Injury
    MUKESH KUMAR JAIN; Fiscal Year: 2010
    ..Results of studies conducted under the auspices of this grant identified KLF4 as a novel and critical regulator of monopoiesis...
  44. Examining the Therapeutic Potential of iPS cells in Duchenne Muscular Dystrophy
    Rita C R Perlingeiro; Fiscal Year: 2010
    ..of direct reprogramming adult mouse and human fibroblasts toward a pluripotent state by introducing Oct3/4, Sox2, Klf4, and c-Myc, has brought new hope for the generation of patient- and disease- specific stem cells without the ..
  45. Transcriptional and Epigenetic Regulation of HSC Generated from iPS and ESC
    Alan Friedman; Fiscal Year: 2009
    ..g., Myc, Klf4, and SV40 T antigen), and thus produce cells with great potential for malignant transformation...
  46. John J Laterra; Fiscal Year: 2016
    ..In addition, the forced expression of these and other TFs (e.g. c-Myc, KLF4) can induce or "reprogram" somatic cells into pluripotent stem (iPS) cells...
  47. Richard L Eckert; Fiscal Year: 2016
    ..suggest that a pathway that includes two master regulators of keratinocyte survival and stem cell fate, DNp63a and KLF4, regulates Ezh2 level. These proteins have not been previously considered as important prevention targets...
  48. Roles of Lin-28 and miRNAs in direct reprogramming of human fibroblasts
    Kathleen Worringer; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Expression of Oct4, Sox2, Klf4, and c-Myc (OSKM) or Oct4, Sox2, Nanog, and Lin-28 in fibroblasts can "reprogram" them to become induced pluripotent stem (iPS) cells, which are highly similar to ..
  49. Gary K Owens; Fiscal Year: 2016
    ..oxPL-induced phenotypic switching in cultured SMC was dependent on the embryonic stem cell (ESC) pluripotency genes KLF4 and Oct4, and mediated in part through chromatin remodeling...
  50. Gorav Ailawadi; Fiscal Year: 2014
    ..The loss of Kruppel like factor-4 (KLF4) has been shown to delay phenotypic switching to an inflammatory phenotype in a ligation-induced model of vascular ..
  51. KEVIN C EGGAN; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): The combined activity of four transcription factors (Oct4, Sox2, cMyc and Klf4) can reprogram adult cells into induced pluripotent stem (iPS) cells...
  52. Gary K Owens; Fiscal Year: 2016
    ..of the embryonic stem cell (ESC) and induced pluripotential stem (iPS) cell pluripotency factors Oct4 and Klf4;and 2) SMC-P specific conditional Klf4 knockout mice show profoundly impaired cardiac repair following MI...
  53. Anne Hamik; Fiscal Year: 2016
    ..Based on our preliminary studies, we find that the 4th member of this family (KLF4) regulates tumor angiogenesis and arteriogenesis...
  54. Cellular plasticity and survival mechanisms in medulloblastoma stem cells
    Ronnie Yoo; Fiscal Year: 2013
    ..Preliminary data also suggest that STAT3 and its downstream target Klf4, are collaboratively regulating the expression of survival genes Mcl-1 and Bclx...
  55. John W Christman; Fiscal Year: 2016
    ..Our supportive data indicate that PU.1 regulates demethylation of Kr[unreadable]ppel-like factor 4 (KLF4) which allows the engagement of PU.1 to the KLF4 enhancer region resulting in transcriptional KLF4 gene expression...
  56. KLF4, myeloid development, and transplantation arteriosclerosis
    A K M KHYRUL WARA; Fiscal Year: 2010
    ..Using a homology screening strategy we identified a member of this family termed KLF4 as being expressed in primary monocytes and in a monocytic restricted pattern among hematopoietic cell lines...
  57. MOLECULAR REGULATION OF SMOOTH MUSCLE DIFFERENTIATION
    Gary K Owens; Fiscal Year: 2010
    ..and that the effects of IL-1b are mediated at least in part through a unique G/C repressor/TCE binding protein KLF4 we identified during the current funding period...
  58. Jonathan P Katz; Fiscal Year: 2015
    ..and carcinogenesis through mechanistic studies of the key transcriptional regulator Kr|ppel-like factor 4 (KLF4)...
  59. Transduction of cells with transcription factors to achieve nuclear reprogramming
    Hidde Ploegh; Fiscal Year: 2009
    ..pluripotent stem cell-like properties by delivery of the necessary transcription factors (Oct4, Sox2, c-Myc and Klf4) in cell-permeable form...
  60. Dieter C Gruenert; Fiscal Year: 2015
    ..using phiC31 Integrase-mediated, sequence-specific integration of a plasmid carrying 2A peptide linked Oct4, Sox2, Klf4, and cMyc reprogramming cDNAs or by using small activating double stranded RNA (saRNA) to transiently enhance the ..
  61. Ruth A Keri; Fiscal Year: 2015
    ..Our studies revealed that KLF4 (Kr[unreadable]ppel-like Factor 4) is a dominant regulator of the epithelial/mesenchymal status in human breast ..
  62. Heterotopic bone from stem cells in peripheral nerves released by neurogenic infl
    ALAN ROBERT DAVIS; Fiscal Year: 2013
    ..the expression of osteogenic protein osterix, brown adipocyte protein UCP1, and the primitive stem cell factors, Klf4 and nanog...
  63. Michael A Dyer; Fiscal Year: 2016
    ..system to quantify the epigenetic reprogramming of individual retinal neurons by using 4 factors (Oct4, Klf4, Sox2, and Myc) and somatic cell nuclear transfer...
  64. DES and the Regulation of the Uterine Cytodifferentiation
    Liang Ma; Fiscal Year: 2010
    ..In aim II, we will use gain and loss of function approaches in vivo to examine whether Klf4 is both necessary and sufficient for DES-induced uterine metaplasia...
  65. Regulation of H/K-ATPase in Kidney and Colon
    BRUCE KONE; Fiscal Year: 2009
    ..expression of the HKalpha2 gene in surface epithelial cells of the distal colon is mediated by the action of KLF4 at an intron 1 enhancer and disruption of the basal -104/-94 NF-kappaB-HDAC6 repressor mechanism...
  66. ROLE OF GKLF IN EPITHELIAL DYSPLASIA
    JOHN RUPPERT; Fiscal Year: 2003
    ..b>GKLF is a major transforming activity in carcinomas that is normally expressed in the differentiating cell layers of ..