KIR2DS3

Summary

Gene Symbol: KIR2DS3
Description: killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 3
Alias: NKAT7, killer cell immunoglobulin-like receptor 2DS3, LOW QUALITY PROTEIN: killer cell immunoglobulin-like receptor 2DS3, MHC class I NK cell receptor, NKAT-7, killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3, natural killer cell inhibitory receptor, natural killer-associated transcript 7
Species: human

Top Publications

  1. pmc NullHap--a versatile application to estimate haplotype frequencies from unphased genotypes in the presence of null alleles
    Robert M Nowak
    Department of Electronics and Information Technology, Institute of Electronic Systems, Warsaw University of Technology, Warsaw, Poland
    BMC Bioinformatics 9:330. 2008
  2. doi Combination of KIR 2DL2 and HLA-C1 (Asn 80) confers susceptibility to type 1 diabetes in Latvians
    A Shastry
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Int J Immunogenet 35:439-46. 2008
  3. ncbi Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors
    N M Valiante
    Department of Structural Biology, Stanford University School of Medicine, California 94305, USA
    Immunity 7:739-51. 1997
  4. ncbi Human diversity in killer cell inhibitory receptor genes
    M Uhrberg
    Department of Structural Biology, Stanford University School of Medicine, California 94305, USA
    Immunity 7:753-63. 1997
  5. ncbi A role for KIR gene variants other than KIR2DS1 in conferring susceptibility to psoriasis
    Rafal Płoski
    Department of Medical Genetics, Medical University in Warsaw, Warsaw, Poland
    Hum Immunol 67:521-6. 2006
  6. ncbi Associations of killer cell immunoglobulin-like receptor genes with complications of rheumatoid arthritis
    E Majorczyk
    Department of Clinical Immunology, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland
    Genes Immun 8:678-83. 2007
  7. doi Combination of KIR and HLA gene variants augments the risk of developing birdshot chorioretinopathy in HLA-A*29-positive individuals
    R D Levinson
    Ocular Inflammatory Disease Center, Jules Stein Eye Institute, David Geffen School of Medicine at UCLA, University of California at Los Angeles, CA 90095 1652, USA
    Genes Immun 9:249-58. 2008
  8. doi Duplication, mutation and recombination of the human orphan gene KIR2DS3 contribute to the diversity of KIR haplotypes
    D Ordonez
    Servicio de Inmunologia, Hospital Universitario Puerta de Hierro, Madrid, Spain
    Genes Immun 9:431-7. 2008
  9. doi KIR and HLA gene combinations in Vogt-Koyanagi-Harada disease
    Ralph D Levinson
    Ocular Inflammatory Disease Center, Jules Stein Eye Institute, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA
    Hum Immunol 69:349-53. 2008
  10. doi Association between killer-cell immunoglobulin-like receptor genotypes and leprosy in Brazil
    D S A Franceschi
    Laboratorio de Imunogenetica, Departamento de Analises Clinicas, Universidade Estadual de Maringa, Maringa, Brazil
    Tissue Antigens 72:478-82. 2008

Scientific Experts

Detail Information

Publications124 found, 100 shown here

  1. pmc NullHap--a versatile application to estimate haplotype frequencies from unphased genotypes in the presence of null alleles
    Robert M Nowak
    Department of Electronics and Information Technology, Institute of Electronic Systems, Warsaw University of Technology, Warsaw, Poland
    BMC Bioinformatics 9:330. 2008
    ..Whereas a number of programs are available for that purpose, none of them can handle loci with both multiple and null alleles...
  2. doi Combination of KIR 2DL2 and HLA-C1 (Asn 80) confers susceptibility to type 1 diabetes in Latvians
    A Shastry
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Int J Immunogenet 35:439-46. 2008
    ..Our results suggest that a combination KIR2DL2- HLA-C1 plays a critical role in susceptibility or protection in Latvians against type 1 diabetes...
  3. ncbi Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors
    N M Valiante
    Department of Structural Biology, Stanford University School of Medicine, California 94305, USA
    Immunity 7:739-51. 1997
    ..Because of these differences, the first donor has subpopulations of NK cells that kill cells of the second donor, whereas the NK cells of the second donor are universally tolerant of cells from the first donor...
  4. ncbi Human diversity in killer cell inhibitory receptor genes
    M Uhrberg
    Department of Structural Biology, Stanford University School of Medicine, California 94305, USA
    Immunity 7:753-63. 1997
    ..Group B comprises more noninhibitory KIR genes and contains at least one additional gene not represented in group A. The KIR locus therefore appears to be polygenic and polymorphic within the human population...
  5. ncbi A role for KIR gene variants other than KIR2DS1 in conferring susceptibility to psoriasis
    Rafal Płoski
    Department of Medical Genetics, Medical University in Warsaw, Warsaw, Poland
    Hum Immunol 67:521-6. 2006
    ..2, pcor = 0.0005) and a decrease in KIR2DS3 restricted to KIR2DS1-positive individuals (OR = 0.2, pcor = 0.005) were evident...
  6. ncbi Associations of killer cell immunoglobulin-like receptor genes with complications of rheumatoid arthritis
    E Majorczyk
    Department of Clinical Immunology, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland
    Genes Immun 8:678-83. 2007
    ..However, RA patients positive for KIR2DL3 and negative for KIR2DS3 had earlier disease diagnosis...
  7. doi Combination of KIR and HLA gene variants augments the risk of developing birdshot chorioretinopathy in HLA-A*29-positive individuals
    R D Levinson
    Ocular Inflammatory Disease Center, Jules Stein Eye Institute, David Geffen School of Medicine at UCLA, University of California at Los Angeles, CA 90095 1652, USA
    Genes Immun 9:249-58. 2008
    ....
  8. doi Duplication, mutation and recombination of the human orphan gene KIR2DS3 contribute to the diversity of KIR haplotypes
    D Ordonez
    Servicio de Inmunologia, Hospital Universitario Puerta de Hierro, Madrid, Spain
    Genes Immun 9:431-7. 2008
    The KIR2DS3 gene is an activating homologue of the inhibitory killer-cell immunoglobulin-like receptors (KIR) that recognize HLA-C molecules, enabling NK cells to survey the normal function of endogenous antigen presentation...
  9. doi KIR and HLA gene combinations in Vogt-Koyanagi-Harada disease
    Ralph D Levinson
    Ocular Inflammatory Disease Center, Jules Stein Eye Institute, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA
    Hum Immunol 69:349-53. 2008
    ..The trends observed in this study are consistent with those reported for other autoimmune diseases...
  10. doi Association between killer-cell immunoglobulin-like receptor genotypes and leprosy in Brazil
    D S A Franceschi
    Laboratorio de Imunogenetica, Departamento de Analises Clinicas, Universidade Estadual de Maringa, Maringa, Brazil
    Tissue Antigens 72:478-82. 2008
    ..Both activating KIR2DS2 and KIR2DS3 frequencies were higher in tuberculoid leprosy (TT) patients than in lepromatous leprosy (LL) patients, and the ..
  11. pmc Dramatically reduced surface expression of NK cell receptor KIR2DS3 is attributed to multiple residues throughout the molecule
    C J VandenBussche
    Department of Oncology, Lombardi Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA
    Genes Immun 10:162-73. 2009
    ..glycosylation status, we demonstrate that an entire killer cell immunoglobulin-like receptor (KIR) locus (KIR2DS3)--assumed earlier to be surface expressed--appears to have little appreciable surface expression in transfected ..
  12. doi Association of killer cell immunoglobulin-like receptors with primary Sjogren's syndrome
    David P Lowe
    Department of Histocompatibility and Immunogenetics, NHS Blood and Transplant, Vincent Drive, Edgbaston, Birmingham, UK
    Rheumatology (Oxford) 48:359-62. 2009
    ....
  13. doi Signatures of natural selection and coevolution between killer cell immunoglobulin-like receptors (KIR) and HLA class I genes
    K J Guinan
    School of Biochemistry and Immunology, Trinity College, Dublin, Ireland
    Genes Immun 11:467-78. 2010
    ..Many of the associations between KIR and HLA in the Irish differ from those previously reported, which argues against universal selective pressures for specific KIR:HLA combinations in diverse human populations...
  14. doi Polymorphisms of KIR gene and HLA-C alleles: possible association with susceptibility to HLA-B27-positive patients with ankylosing spondylitis
    Yu Lian Jiao
    Central Laboratory, Provincial Hospital affiliated to Shandong University, Jinan 250021, People s Republic of China
    J Clin Immunol 30:840-4. 2010
    ....
  15. pmc Association of KIR2DS1 and KIR2DS3 with fatal outcome in Ebola virus infection
    Nadia Wauquier
    Centre International de Recherches Medicales de Franceville, Franceville, Gabon
    Immunogenetics 62:767-71. 2010
    ..We showed that the activating KIR2DS1 and KIR2DS3 genes associate with fatal outcome in Ebola virus infection...
  16. pmc Different patterns of evolution in the centromeric and telomeric regions of group A and B haplotypes of the human killer cell Ig-like receptor locus
    Chul Woo Pyo
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 5:e15115. 2010
    ..The results suggest the common ancestor of A and B haplotypes combined a B-like centromeric region with an A-like telomeric region...
  17. pmc Innate immune genes synergize to predict increased risk of chronic disease in hepatitis C virus infection
    Megan M Dring
    Natural Killer Cell Group, School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    Proc Natl Acad Sci U S A 108:5736-41. 2011
    ..The NK cell gene KIR2DS3 was significantly increased in patients with chronic infection [odds ratio (OR) 1...
  18. ncbi Association of killer cell immunoglobulin-like receptor genotypes with microscopic polyangiitis
    Risa Miyashita
    University of Tokyo, Hongo, Tokyo, Japan
    Arthritis Rheum 54:992-7. 2006
    ..In this study, we examined possible associations of the presence or absence of KIR loci with a genetic predisposition to MPA...
  19. ncbi Low number of donor activating killer immunoglobulin-like receptors (KIR) genes but not KIR-ligand mismatch prevents relapse and improves disease-free survival in leukemia patients after in vivo T-cell depleted unrelated stem cell transplantation
    Nicolaus Kroger
    Bone Marrow Transplantation, University Hospital Hamburg, Hamburg, Germany
    Transplantation 82:1024-30. 2006
    ..two broad haplotypes exist: KIR-haplotype A mainly encode for inhibitory receptors and only for one activating (KIR2DS4), whereas the group B haplotype encodes more for activating KIRs (KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS5 und KIR3DS1).
  20. ncbi Prognosis after unmanipulated HLA-haploidentical blood and marrow transplantation is correlated to the numbers of KIR ligands in recipients
    Xiang Yu Zhao
    Peking University Institute of Hematology, Peking University People s Hospital, Beijing, China
    Eur J Haematol 78:338-46. 2007
    ....
  21. doi Limited allelic diversity of stimulatory two-domain killer cell immunoglobulin-like receptors
    Lihua Hou
    Department of Pediatrics, CW Bill Young Marrow Donor Recruitment and Research Program, Georgetown University Medical Center, Washington, DC, USA
    Hum Immunol 69:174-8. 2008
    ..Specific loci were present in from 26% (KIR2DS3) to 98% (KIR2DS4) of individuals...
  22. ncbi Distribution of natural killer cell immunoglobulin-like receptor sequences in three ethnic groups
    P J Norman
    South Thames Tissue Typing, Guy s Hospital, London, UK
    Immunogenetics 52:195-205. 2001
    ..for the presence of 12 putative KIR loci, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR3DL1, KIR3DL2, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, and KIR3DS1, using modified PCR sequence-specific primers...
  23. ncbi CD94-NKG2A receptors regulate antiviral CD8(+) T cell responses
    Janice M Moser
    Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Nat Immunol 3:189-95. 2002
    ..Here we show that the natural killer cell inhibitory receptor, CD94-NKG2A, is up-regulated by antiviral CD8(+) T cells during acute polyoma infection and is ..
  24. ncbi Expression, crystallization and preliminary crystallographic analysis of the extracellular IgV-like domain of the human natural killer cell inhibitory receptor p75/AIRM1
    Nazzareno Dimasi
    Center for Advanced Research in Biotechnology, 9600 Gudelsky Drive, Rockville, MD, USA
    Acta Crystallogr D Biol Crystallogr 59:1856-8. 2003
    ..The systematic absences indicate that the space group is P2(1). Assuming one molecule per asymmetric unit, V(M) (the Matthews coefficient) was calculated to be 1.879 A(3) Da(-1) and the solvent content was estimated to be 32.01%...
  25. ncbi Structure of the saccharide-binding domain of the human natural killer cell inhibitory receptor p75/AIRM1
    Nazzareno Dimasi
    Istituto Giannina Gaslini, Largo Gerolamo Gaslini 5, 16147 Genova, Italy
    Acta Crystallogr D Biol Crystallogr 60:401-3. 2004
    ..crystal structure of the functional N-terminal domain from the extracellular region of the human natural killer cell inhibitory receptor p75/AIRM1 or Siglec-7 has been determined at 1...
  26. doi Killer immunoglobulin-like receptor ligand HLA-Bw4 protects against multiple sclerosis
    Aslaug R Lorentzen
    Department of Neurology, Faculty Division Ulleval, Oslo University Hospital, University of Oslo, Oslo, Norway
    Ann Neurol 65:658-66. 2009
    ..We investigated the HLA class I alleles defined by their KIR binding motifs and the KIR genes to evaluate whether these genes could influence MS susceptibility or severity, alone or in combination...
  27. doi Distribution of killer-cell immunoglobulin-like receptor genes in Eastern mainland Chinese Han and Taiwanese Han populations
    G Q Wu
    Bone Marrow Transplantation Center, School of Medicine, The First Affiliated Hospital of Zhejiang University Medical School, Hangzhou, China
    Tissue Antigens 74:499-507. 2009
    ..Our data showed that there were minor distinctions in KIR gene frequencies, genotypes and LD between the two populations, which shed light on a possible geographic genetic demarcation among different Chinese communities...
  28. doi Killer cell immunoglobulin-like receptor gene-cluster 3DS1-2DL5-2DS1-2DS5 predisposes susceptibility to Vogt-Koyanagi-Harada syndrome in Japanese individuals
    Ralph D Levinson
    Ocular Inflammatory Disease Center, Jules Stein Eye Institute, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, CA 90024, USA
    Hum Immunol 71:192-4. 2010
    ..9% vs 98.8%, p = 0.00006). These data suggest that the genotypes encoding a dominant activating KIR receptor repertoire predispose susceptibility to VKH disease...
  29. pmc KIR and HLA genotypes are associated with disease progression and survival following autologous hematopoietic stem cell transplantation for high-risk neuroblastoma
    Jeffrey M Venstrom
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Clin Cancer Res 15:7330-4. 2009
    ..We hypothesized that patients with a "missing ligand" KIR-HLA compound genotype may uniquely benefit from autologous hematopoietic stem cell transplantation (HSCT)...
  30. pmc Distribution of killer cell immunoglobulin-like receptors (KIR) and their HLA-C ligands in two Iranian populations
    Susan E Hiby
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB21QP, UK
    Immunogenetics 62:65-73. 2010
    ....
  31. doi Compound KIR-HLA genotype analyses in the Iranian population by a novel PCR-SSP assay
    N Tajik
    Division of Transplant Immunology and Immunogenetics, Department of Immunology, Iran University of Medical Sciences, Tehran, Iran
    Int J Immunogenet 37:159-68. 2010
    ..In contrast, existence of activating KIR genes without normal endogenous ligands, potentially arms the NK population for competent immunosurveillance and stronger defense against infections...
  32. doi Report from the killer immunoglobulin-like receptor (KIR) anthropology component of the 15th International Histocompatibility Workshop: worldwide variation in the KIR loci and further evidence for the co-evolution of KIR and HLA
    J A Hollenbach
    Center for Genetics, Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Tissue Antigens 76:9-17. 2010
    ..Much more allelic variation was observed for the A haplotype locus 3DL1, with several alleles observed at moderate frequencies and extensive variation observed between populations...
  33. pmc Linkage disequilibrium organization of the human KIR superlocus: implications for KIR data analyses
    Pierre Antoine Gourraud
    Department of Neurology, University of California, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Immunogenetics 62:729-40. 2010
    ..Several extended KIR haplotypes in the study population were identified (KIR2DS2*POS-KIR2DL2*001-KIR2DL5B*002-KIR2DS3*00103-KIR2DL1*00401; KIR2DL4*011-KIR3DL1/S1*005-KIR2DS4*003-KIR3DL2*003; KIR2DL4*00802-KIR3DL1/S1*004-KIR2DS4*006-..
  34. pmc Skin Cancer Risk Is Modified by KIR/HLA Interactions That Influence the Activation of Natural Killer Immune Cells
    Karin A Vineretsky
    Division of Environmental Health Sciences, School of Public Health, University of Minnesota, Minneapolis, Minnesota
    Cancer Res 76:370-6. 2016
    ..10-5.21), and there was a significant interaction between HLA-C and the activating gene KIR2DS3 for BCC (Pinteraction = 0.005)...
  35. doi The investigation of killer cell immunoglobulin-like receptor genotyping in patients with systemic lupus erytematosus and systemic sclerosis
    Jülide Duymaz Tozkır
    Health Services Vocational College, Trakya University, Edirne, Turkey
    Clin Rheumatol 35:919-25. 2016
    ..In the SLE group, the KIR2DL5, KIR2DL5B and KIR2DS3 genes were significantly more frequent, and KIR2DL3 gene was significantly less than in controls (p values <0...
  36. pmc Direct binding of a soluble natural killer cell inhibitory receptor to a soluble human leukocyte antigen-Cw4 class I major histocompatibility complex molecule
    Q R Fan
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 93:7178-83. 1996
    ..The formation of complexes between soluble, recombinant molecules indicates that HLA-Cw4 is sufficient for specific ligation by the NK receptor and that neither glycoprotein requires carbohydrate for the interaction...
  37. ncbi Initial sequencing and analysis of the human genome
    E S Lander
    Whitehead Institute for Biomedical Research, Center for Genome Research, Cambridge, MA 02142, USA
    Nature 409:860-921. 2001
    ..We also present an initial analysis of the data, describing some of the insights that can be gleaned from the sequence...
  38. ncbi Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex
    Q R Fan
    Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
    Nat Immunol 2:452-60. 2001
    ..Most of the amino acids that differ between human and chimpanzee KIRs with HLA-C specificities form solvent-accessible clusters outside the KIR-HLA interface, which suggests undiscovered interactions by KIRs...
  39. ncbi Binding of the natural killer cell inhibitory receptor Ly49A to its major histocompatibility complex class I ligand. Crucial contacts include both H-2Dd AND beta 2-microglobulin
    Jian Wang
    Molecular Biology Section, Laboratory of Immunology, NIAID, National Institutes of Health, Bethesda, Maryland 20892 1892, USA
    J Biol Chem 277:1433-42. 2002
    ..H-2D(d) interface at Site 2 includes a network of water molecules, suggesting a molecular basis for allelic specificity in natural killer cell recognition...
  40. pmc Increased expression of the natural killer cell inhibitory receptor CD85j/ILT2 on antigen-specific effector CD8 T cells and its impact on CD8 T-cell function
    M Nedim Ince
    CBR Institute for Biomedical Research and Department of Pediatrics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Immunology 112:531-42. 2004
    ..Thus, ILT2 expression, increased on antiviral CD8 cells in chronic infection, may interfere with protective CD8 T-cell function by suppressing IFN-gamma production...
  41. ncbi Chain-terminating natural mutations affect the function of activating KIR receptors 3DS1 and 2DS3
    Lihui Luo
    UCLA Immunogenetics Center, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095 1652, USA
    Immunogenetics 59:779-92. 2007
    ..2DS3, we developed a novel direct-sequencing method and analyzed DNA samples of 175 KIR3DS1(+) individuals and 72 KIR2DS3(+) individuals from the white population...
  42. doi Distribution of KIR genes in the Iranian population
    N Tajik
    Division of Transplant Immunology and Immunogenetics, Department and Research Center of Immunology, Iran University of Medical Sciences, Tehran, Iran
    Tissue Antigens 74:22-31. 2009
    ..In addition, we found a new genotype (KIR2DL2, KIR2DL4, KIR2DL5, KIR3DL2, KIR3DL3, KIR2DS2, KIR2DS3, KIR2DS5, KIR3DS1 and KIR3DP1) in our samples...
  43. doi Killer cell immunoglobulin-like receptor gene polymorphisms in patients with leukemia: possible association with susceptibility to the disease
    Yan Zhang
    Department of Blood Group Research, Shaan xi Province Blood Center, Xi an, Shaan Xi, China
    Leuk Res 34:55-8. 2010
    ..001) while the activating KIR2DS3 was lower in patients with ALL compared with healthy controls (P<0.05)...
  44. ncbi [Genotype analysis of killer cell immunoglobulin-like receptors in Graves' disease patients]
    Hai qing Zhang
    Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 25:699-701. 2009
    ..Killer cell immunoglobulin-like receptor (KIR) can modulate the activity of NK and T lymphocyte. To investigate whether the KIR genotype possessing a susceptibility to Graves disease (GD)...
  45. ncbi Frequencies of killer immunoglobulin-like receptor genotypes influence susceptibility to spontaneous abortion
    I Nowak
    Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland
    J Appl Genet 50:391-8. 2009
    ..In addition, the results suggest for the first time that sporadic and recurrent spontaneous abortions as well as miscarriage in the presence or absence of autoantibodies may have different KIR genotypic backgrounds...
  46. doi Disparate distribution of activating and inhibitory killer cell immunoglobulin-like receptor genes in patients with systemic lupus erythematosus
    Y F Hou
    Department of Rheumatology, Provincial Hospital affiliated to Shandong University, Ji nan 250021, China
    Lupus 19:20-6. 2010
    ..7% versus 66.7%, p = 0.022). The results suggest that a genetic disturbance between activating and inhibitory KIR genes may be one of the key factors underlying the pathogenesis of SLE...
  47. ncbi [Effects of killer immunoglobulin-like receptor and human leukocyte antigen class I ligand on the prognosis of related donor hematopoietic stem cell transplantation]
    Hua Wang
    State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, CAMS and PUMC, Tianjin 300020, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 31:533-7. 2009
    ..To study the genotype distribution and the effects of killer immunoglobulin-like receptors (KIR) and human leukocyte antigen (HLA) class I ligand on related donor hematopoietic stem cell transplantation (HSCT)...
  48. doi Natural killer-cell receptor polymorphisms and posttransplantation non-Hodgkin lymphoma
    Martin Stern
    Immunobiology Laboratory, Department of Biomedicine, University Hospital Basel, Basel, Switzerland
    Blood 115:3960-5. 2010
    ..49, 95% confidence interval 1.07-2.05, P = .02). KIR ligands and cytokine polymorphisms had no effect on survival. None of the genetic loci analyzed emerged as risk factors for lymphoma development...
  49. ncbi [Killer cell immunoglobin-like receptor and its ligand gene polymorphisms in Hunan Han patients with type 1 diabetes]
    Yu Yu Tan
    Institute of Metabolism and Endocrinology, Diabetic Center, Metabolic Syndrome Research Center, Second Xiangya Hospital, Central South University, Changsha 410011, China
    Zhonghua Yi Xue Za Zhi 90:236-40. 2010
    ..To investigate the association of Killer cell immunoglobin-like receptor (KIR) gene and KIRs'ligand (HLA-C) gene polymorphisms with type 1 diabetes (T1DM)...
  50. pmc Thirty allele-level haplotypes centered around KIR2DL5 define the diversity in an African American population
    Lihua Hou
    Department of Pediatrics, Georgetown University Medical Center, Washington, DC 20057, USA
    Immunogenetics 62:491-8. 2010
    ..Based on linkage with KIR2DS1, KIR2DS3, KIR2DS5, KIR2DL2, KIR2DL3, and KIR3DS1 alleles, seven haplotypes of KIR2DL5A and 23 haplotypes of KIR2DL5B were ..
  51. doi Human leukocyte antigen-C and killer cell immunoglobulin-like receptor gene polymorphisms among patients with syphilis in a Chinese Han population
    Yun long Zhuang
    Blood Center of Shandong Province, Jinan, China
    APMIS 120:828-35. 2012
    ..Framework genes KIR2DL4, KIR3DL2, KIR3DL3 and KIR3DP1 were present in all individuals. The frequencies of KIR2DS3 and KIR3DS1 were higher in syphilis patients than in healthy controls (p = 0.030 and p = 0...
  52. pmc Recombinant structures expand and contract inter and intragenic diversification at the KIR locus
    Chul Woo Pyo
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    BMC Genomics 14:89. 2013
    ....
  53. doi Killer-cell immunoglobulin-like receptors and falciparum malaria in southwest Nigeria
    Subulade A Olaniyan
    Institute of Child Health, College of Medicine, University of Ibadan, Ibadan, Nigeria Electronic address
    Hum Immunol 75:816-21. 2014
    ..The genes KIR2DL5, KIR2DS3 and KIR2DS5 were present in a significantly higher proportion of individuals in the asymptomatic control group ..
  54. doi IFNL cytokines do not modulate human or murine NK cell functions
    Maria H Morrison
    Natural Killer Cell Research Group, School of Biochemistry and Immunology, Trinity College Dublin, Trinity Biomedical Science Institute, 152 160 Pearse Street, Dublin 2, Ireland
    Hum Immunol 75:996-1000. 2014
    ..We have recently shown that rs1299860 (an IFNL3 associated SNP) and an NK cell gene, KIR2DS3, synergised to increase the odds of chronic infection in a homogenous cohort of Irish women infected with HCV...
  55. pmc Impact of "Killer Immunoglobulin-Like Receptor /Ligand" Genotypes on Outcome following Surgery among Patients with Colorectal Cancer: Activating KIRs Are Associated with Long-Term Disease Free Survival
    Kemal Beksac
    Department of General Surgery, Hacettepe University, Ankara, Turkey
    PLoS ONE 10:e0132526. 2015
    ..017 and p=0.024); and KIR2DS2 and KIR2DS3 (both activating KIRs) were observed less frequently (p=0.005 and p=0.043)...
  56. doi Study of genetic diversity of KIR and TLR in the Rabhas, an endogamous primitive tribe of India
    Pokhraj Guha
    Cellular Immunology Laboratory, Department of Zoology, University of North Bengal, Raja Rammohunpur, Siliguri, West Bengal 734013, India
    Hum Immunol 76:789-94. 2015
    ..The observed frequencies of the KIR genes (except framework and pseudogene loci) ranged between 0.26 (KIR2DS3) and 0.96 (KIR2DL1)...
  57. doi Genetic associations of killer immunoglobulin like receptors and class I human leukocyte antigens on childhood acute lymphoblastic leukemia among north Indians
    Maneesh Kumar Misra
    Department of Medical Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow 226014, Uttar Pradesh, India
    Hum Immunol 77:41-6. 2016
    ..We aimed to determine the role of KIR genes and their HLA ligands in genetic predisposition of childhood acute lymphoblastic leukemia (ALL)...
  58. ncbi Distribution of killer cell immunoglobulin-like receptors in the Greek population
    Dimitra Niokou
    Department of Immunology and National Tissue Typing Laboratory, General Hospital of Athens, 154 Mesogeion Avenue, GR 11527 Athens, Greece
    Hum Immunol 64:1167-76. 2003
    ..of the putative KIR loci KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR3DL1, KIR3DL2, KIR3DL3, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, and KIR3DS1 using modified polymerase chain reaction sequence-specific primers...
  59. pmc A study of KIR genes and HLA-C in Vogt-Koyanagi-Harada disease in Saudi Arabia
    Atia Sheereen
    Histocompatibility and Immunogenetics Research Unit, Stem Cell Therapy Program, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    Mol Vis 17:3523-8. 2011
    ..Accordingly, we sought to determine the incidence of KIR genes and KIR ligand (Human leukocytes antigen [HLA-C]) interaction in a cohort of Saudi VKH patients and to compare the findings to normal controls...
  60. doi Potential implication of activating killer cell immunoglobulin-like receptor and HLA in onset of pulmonary tuberculosis
    C Lu
    Department of Laboratory Medicine, Provincial Hospital affiliated to Shandong University, Jinan, China
    Scand J Immunol 76:491-6. 2012
    ..In addition, individuals with no KIR2DS3 and no Cw*08 were higher in controls than in PTB...
  61. pmc Natural killer cell inhibitory receptor expression in humans and mice: a closer look
    Michal Sternberg-Simon
    The Mina and Everard Goodman Faculty of Life Sciences, bar Ilan University Ramat Gan, Israel
    Front Immunol 4:65. 2013
    ..Thus, while human and murine inhibitory receptor repertoires differed in details, there may also be shared principles governing NK cell repertoire formation in these two species...
  62. pmc Association of killer cell immunoglobulin-like receptor polymorphisms with chronic hepatitis C and responses to therapy in Brazil
    Janaina Mota de Vasconcelos
    Instituto de Ciencias Biologicas, Universidade Federal do Para, Belem, PA, Brazil
    Genet Mol Biol 36:22-7. 2013
    ..Moreover, KIR2DS2 and KIR2DS2+HLA-C(Asp80) (p < 0.0001, OR = 2.51; p = 0.0084, OR = 2.62) and KIR2DS3 (p < 0.0001; OR = 2.57) were associated with chronic infection, independently from KIR2DL2...
  63. pmc Variation in both IL28B and KIR2DS3 genes influence pegylated interferon and ribavirin hepatitis C treatment outcome in HIV-1 co-infection
    Ciara Keane
    Natural Killer Cell Group, School of Biochemistry and Immunology, Trinity College, Dublin, Ireland
    PLoS ONE 8:e66831. 2013
    ..We have recently shown that the NK cell gene, KIR2DS3 and a SNP associated with the IL28B gene synergise to increase the risk of chronic infection in primary HCV mono-..
  64. ncbi Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains
    N Wagtmann
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
    Immunity 2:439-49. 1995
    ..These data revealed a repertoire of NK cells with clonally distributed p58 receptors exhibiting diversity in both extracellular and intracellular domains...
  65. ncbi Alternatively spliced forms of human killer inhibitory receptors
    C Döhring
    Basel Institute for Immunology, Grenzacherstrasse 487, Basel CH 4005, Switzerland
    Immunogenetics 44:227-30. 1996
  66. ncbi A novel surface molecule homologous to the p58/p50 family of receptors is selectively expressed on a subset of human natural killer cells and induces both triggering of cell functions and proliferation
    C Bottino
    Istituto Scientifico Tumori, Genova, Italy
    Eur J Immunol 26:1816-24. 1996
    ....
  67. ncbi Structure of the inhibitory receptor for human natural killer cells resembles haematopoietic receptors
    Q R Fan
    Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 389:96-100. 1997
    ..The topology of the domains and their arrangement relative to each other reveal a relationship to the haematopoietic receptor family, with implications for the signalling mechanism in NK cells...
  68. pmc Structure of human histocompatibility leukocyte antigen (HLA)-Cw4, a ligand for the KIR2D natural killer cell inhibitory receptor
    Q R Fan
    Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts 02138, USA
    J Exp Med 190:113-23. 1999
    ..The surface of HLA-Cw4 has electrostatic complementarity to the surface of the NK cell inhibitory receptor KIR2D...
  69. ncbi Cobalt-mediated dimerization of the human natural killer cell inhibitory receptor
    Q R Fan
    Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts 02138, USA
    J Biol Chem 275:23700-6. 2000
    ....
  70. ncbi Development of a PCR-SSOP approach capable of defining the natural killer cell inhibitory receptor (KIR) gene sequence repertoires
    K A Crum
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast
    Tissue Antigens 56:313-26. 2000
    ..The segregation analysis concluded that at least 3 distinct gene loci encode 2DL1-4 and at least 4 gene loci encode the non-inhibitory KIR2DS1-2DS5. In the case of 3DL1-2 and 3DS1, our data suggests 3 gene loci, one for each subfamily...
  71. ncbi Assessment of killer cell immunoglobulinlike receptor expression and corresponding HLA class I phenotypes demonstrates heterogenous KIR expression independent of anticipated HLA class I ligands
    Sven Becker
    Institute of Transfusion Medicine and Immunohematology, RCBDS, Frankfurt, Germany
    Hum Immunol 64:183-93. 2003
    ..In conclusion, the surface expression of KIRs in individuals with different HLA class I genotypes indicates that other non-HLA class I encoded factors contribute to the shaping of the KIR repertoire...
  72. ncbi Distribution of killer cell immunoglobulin-like receptor genes in the Chinese Han population
    K Jiang
    HLA Typing Laboratory, Blood Center of Zhejiang Province, Hangzhou, Zhejiang Province, China
    Tissue Antigens 65:556-63. 2005
    ..Our data demonstrated that the Chinese Han population is distinct in KIR gene frequencies and putative KIR haplotypes in comparison to some other populations...
  73. ncbi Amelioration of acute graft-versus-host disease by NKG2A engagement on donor T cells
    Hiroki Kawamura
    Department of Immunology, Niigata University School of Medicine, Niigata, Japan
    Eur J Immunol 35:2358-66. 2005
    ..In a murine model, we found that donor T cells expressed a natural killer cell inhibitory receptor, CD94/NKG2A, during the course of aGVHD...
  74. ncbi Diversity of killer cell immunoglobulin-like receptor genes in Pacific Islands populations
    Marija Velickovic
    Molecular Genetics Section, Tissue Typing, Australian Red Cross Blood Service, 153 Clarence Street, Sydney, NSW 2000, Australia
    Immunogenetics 58:523-32. 2006
    ..82), compared to the less-frequently observed KIR2DL2 (0.27), KIR2DL5 (0.30), KIR2DS1 (0.19), KIR2DS2 (0.27), KIR2DS3 (0.16), KIR2DS5 (0.17), and KIR3DS1 (0.18) genes...
  75. ncbi Altered natural killer cells in type 1 diabetic patients
    Melanie Rodacki
    Joslin Diabetes Center, Boston, MA, USA
    Diabetes 56:177-85. 2007
    ..Finally, type 1 diabetic patients had an increased frequency of KIR gene haplotypes that include the activating KIR2DS3 gene, with a genetic interaction between the KIR and HLA complexes...
  76. ncbi Distribution of the killer cell immunoglobulin-like receptors in Mexican Mestizos
    G Contreras
    Department of Immunology and Immunogenetics, Instituto de Diagnostico y Referencia Epidemiologicos, INDRE, Secretary of Health, Mexico City, Mexico
    Tissue Antigens 69:125-9. 2007
    ..43%), kir2dl2 (37.64%), kir2dl3 (76.43%), kir2dl5 (29.29%), kir3ds1 (23.02%), kir2ds1 (21.83%), kir2ds2 (37.64%), kir2ds3 (50.93%), kir2ds4 (86.93%), kir2ds5 (29.29%), kir2dp1 (86.39%)...
  77. pmc Donor-recipient combinations of group A and B KIR haplotypes and HLA class I ligand affect the outcome of HLA-matched, sibling donor hematopoietic cell transplantation
    Karina L McQueen
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA
    Hum Immunol 68:309-23. 2007
    ..Analysis of the KIR genes individually revealed KIR2DS3 as a protective factor for chronic GVHD...
  78. pmc Polymorphisms of killer cell immunoglobulin-like receptor gene: possible association with susceptibility to or clearance of hepatitis B virus infection in Chinese Han population
    Lu Zhi-ming
    Department of Center Laboratory, Shandong Provincial Hospital, Shandong University, 324 Jing Wu Rd 250021 Jinan, China
    Croat Med J 48:800-6. 2007
    ..To explore whether killer cell immunoglobulin-like receptors (KIR) gene polymorphisms are associated with susceptibility to persistent hepatitis B virus (HBV) infection or HBV clearance...
  79. doi Asian population frequencies and haplotype distribution of killer cell immunoglobulin-like receptor (KIR) genes among Chinese, Malay, and Indian in Singapore
    Yi Chuan Lee
    Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Science Drive 2, MD4, Singapore, Singapore, 117597
    Immunogenetics 60:645-54. 2008
    ....
  80. doi The 5' intergenic, promoter, pseudoexon 3 and complete coding sequences of the hybrid gene KIR2DS3*002
    D Ordonez
    Servicio de Inmunologia, Hospital Universitario Puerta de Hierro, Madrid, Spain
    Tissue Antigens 72:504-5. 2008
    Genomic and mRNA sequences support the KIR2DS3*002 gene being a hybrid of KIR2DS3*00103 and KIR2DS5.
  81. doi Killer cell immunoglobulin-like receptor gene diversity in a Southern Brazilian population from the state of Paraná
    Cristiane Conceição Chagas Rudnick
    Laboratorio de Imunogenetica, Departamento de Analises Clinicas, Universidade Estadual de Maringa, PR, Brazil
    Hum Immunol 69:872-6. 2008
    ....
  82. doi Diversity of killer cell immunoglobulin-like receptor genes in Indonesian populations of Java, Kalimantan, Timor and Irian Jaya
    M Velickovic
    Department of Molecular Genetics, Tissue Typing, Australian Red Cross Blood Service, Sydney, New South Wales, Australia
    Tissue Antigens 73:9-16. 2009
    ....
  83. doi KIR genes and KIR ligands affect occurrence of acute GVHD after unrelated, 12/12 HLA matched, hematopoietic stem cell transplantation
    K Ludajic
    Division of Blood Group Serology, Medical University of Vienna, Vienna, Austria
    Bone Marrow Transplant 44:97-103. 2009
    ..24, 95% CI: 0.07-0.85, P=0.027). Thus, our single center study provides evidence for the modification of aGVHD risk by KIRs and their ligands...
  84. ncbi [Analysis of natural killer cell immunoglobulin-like receptor genes in Chinese]
    Shao Jie Fu
    Department of Organ Transplantation, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 29:109-13. 2009
    ..To investigate the genotypes of natural killer cell immunoglobulin-like receptor (KIR) genes and their frequencies in Chinese subjects and explore the mechanism of the actions of nature killer cells...
  85. doi Distribution of killer cell immunoglobulin-like receptor (KIR) genotypes in patients with familial Mediterranean fever
    Rami A R Mahfouz
    Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Beirut, Lebanon
    Genet Test Mol Biomarkers 13:91-5. 2009
    ..This is the first report that describes the KIR genotypic profile in this important clinical disease...
  86. doi Killer cell immunoglobulin-like receptor genotype and killer cell immunoglobulin-like receptor-human leukocyte antigen C ligand compatibility affect the severity of hepatitis C virus recurrence after liver transplantation
    Alejandro Espadas De Arias
    Department of Regenerative Medicine, Organ and Tissue Transplantation Immunology, Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena, Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy
    Liver Transpl 15:390-9. 2009
    ..04). These preliminary results indicate that the KIR genotype and KIR-HLA-C ligand compatibility play roles in the recurrence and progression of hepatitis C disease in liver transplant recipients...
  87. ncbi [Genotype and haplotype analysis of killer cell immunoglobulin-like receptors in ankylosing spondylitis]
    Bing Chang Zhang
    Department of Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China
    Zhonghua Yi Xue Za Zhi 89:91-5. 2009
    ..To investigate the association of killer cell immunoglobulin-like receptors (KIR) genotype and haplotype with ankylosing spondylitis (AS)...
  88. doi Activating killer immunoglobulin-like receptor incompatibilities enhance graft-versus-host disease and affect survival after allogeneic hematopoietic stem cell transplantation
    Sebastian Giebel
    Department of Hematology and Bone Marrow Transplantation, Silesian Medical University, Katowice, Poland
    Eur J Haematol 83:343-56. 2009
    ..In this study, we prospectively evaluated the impact of donor and recipient activating KIR genes on outcome of allogeneic hematopoietic stem cell transplantation (alloHSCT) for patients with hematological malignancies...
  89. doi Activating killer cell immunoglobulin-like receptor genes' association with recurrent miscarriage
    Rafael Gustavo Vargas
    Genetics Department, Universidade Federal do Parana, Curitiba, Brazil
    Am J Reprod Immunol 62:34-43. 2009
    ..The aim of this study was to investigate if KIR genes coding for receptors known to have as ligands HLA class I molecules are correlated with RM...
  90. ncbi [Killer immunoglobulin-like receptor gene genotype and expression pattern in NK-92MI and K562 cells]
    Li Ping Dou
    Department of Hematology, PLA General Hospital of China, Beijing 100853, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 25:767-9. 2009
    ..To make clear the repertoire of Killer immunoglobulin-like receptor at the level of DNA and RNA in NK-92MI and K562 cells and compare KIRs gene genotype and expression patterns in both cells...
  91. pmc Killer cell immunoglobulin-like receptors in HLA-B27-associated acute anterior uveitis, with and without axial spondyloarthropathy
    Ralph D Levinson
    Ocular Inflammatory Disease Center, Jules Stein Eye Institute, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, California, USA
    Invest Ophthalmol Vis Sci 51:1505-10. 2010
    ..To determine associations between polymorphic genes that encode KIRs and their HLA class I ligands in patients with HLA-B27-associated acute anterior uveitis (AAU), with and without axial spondyloarthropathy (axial SpA)...
  92. pmc Activating killer cell immunoglobulin-like receptors 3DS1 and 2DS1 protect against developing the severe form of recurrent respiratory papillomatosis
    Vincent R Bonagura
    Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY 11030, USA
    Hum Immunol 71:212-9. 2010
    ..Our data suggest that NK cells expressing activating receptors KIR3DS1 and KIR2DS1 may be necessary to trigger an effective early immune response against HPV-infected targets to establish resistance to RRP development...
  93. ncbi [Killer immunoglobulin-like receptor gene genotype and expression pattern in healthy people]
    Li Ping Dou
    Department of Hematology, PLA General Hospital, Beijing 100853, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 18:132-5. 2010
    ..The phenotypes including KIR2DL1, KIR2DL2, KIR2DL3, KIR3DL1, KIR2DS1, KIR2DS3, KIR2DS2/4 gene were determined by RT-PCR...
  94. ncbi [Relationship between CMV reactivation and KIR haplotype/HLA-Cw genotype in patients after unrelated-donor hematopoietic stem cell transplantation.]
    Xiao jin Wu
    The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Suzhou 215006, China
    Zhonghua Xue Ye Xue Za Zhi 30:741-4. 2009
    ..To explore the relationship between CMV reactivation and KIR haplotype or HLA-Cw genotype in patients after unrelated-donor hematopoietic stem cell transplantation (HSCT)...
  95. doi The beneficial impact of missing KIR ligands and absence of donor KIR2DS3 gene on outcome following unrelated hematopoietic SCT for myeloid leukemia in the Chinese population
    G Q Wu
    Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
    Bone Marrow Transplant 45:1514-21. 2010
    ..034, HR=0.430) and disease-free survival (DFS) (P=0.024, HR=0.445). Meanwhile, the presence of donor-activating KIR2DS3 gene was associated with increased relapse risk (P=0.003, HR=5.046), decreased OS (P=0.004, HR=3...
  96. doi The role of killer immunoglobulin-like receptor haplotypes on the outcome of unrelated donor haematopoietic SCT for thalassaemia
    R Littera
    Centro Regionale Trapianti, Ospedale R Binaghi ASL Cagliari, Cagliari, Italy
    Bone Marrow Transplant 45:1618-24. 2010
    ....
  97. doi Distribution of killer cell immunoglobulin-like receptor genes in the mestizo population from Venezuela
    A Conesa
    Instituto de Inmunologia, Facultad de Medicina, Universidad Central de Venezuela, FOCIS Center of Excellence, Caracas, Venezuela
    Tissue Antigens 75:724-9. 2010
    ..7% of the population of which 25.9% were individuals homozygous for haplotype A. The frequencies of KIR genes reflect the ethnic admixture existing in the mestizo Venezuelan population...
  98. doi HLA-DQA1*0505 sharing and killer immunoglobulin-like receptors in sub fertile couples: report from the 15th International Histocompatibility Workshop
    M Varla-Leftherioti
    Immunobiology Department, Helena Venizelou Maternity Hospital, Athens, Greece
    Tissue Antigens 75:668-72. 2010
    ..The results oppose the suggestion that increased HLA-DQA1*0505 sharing predispose to RSA or RIF. The KIR2DL3-C1 combination (or lack of the KIR2DL1-C2 one) is associated with implantation failure...
  99. doi Association of killer cell immunoglobulin-like receptor 2DL5 with systemic lupus erythematosus and accompanying infections
    Yasutaka Kimoto
    Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Rheumatology (Oxford) 49:1346-53. 2010
    ..Identification of the association of killer cell immunoglobulin-like receptor (KIR) genes with SLE and accompanying infections...
  100. doi KIR2DS3 is associated with protection against acute myeloid leukemia
    Farhad Shahsavar
    Division of Transplant Immunology and Immunogenetics, Department of Immunology, Iran University of Medical Sciences, Tehran, Iran
    Iran J Immunol 7:8-17. 2010
    ..Interaction between killer cell immunoglobulin-like receptors (KIR) and human leukocyte antigen (HLA) class I molecules is important for regulation of natural killer (NK) cell function...
  101. doi HLA and KIR frequencies in Sicilian Centenarians
    Florinda Listi
    Immunosenescence Unit, Department of Pathobiology and Biomedical Methodologies, University of Palermo, Palermo, Italy
    Rejuvenation Res 13:314-8. 2010
    ..This kind of study is important to better understand aging and longevity, hence enhancing the planning of antiaging strategies...