Kim-1

Summary

Gene Symbol: Kim-1
Description: hepatitis A virus cellular receptor 1
Alias: CD365, HAVCR, HAVCR-1, KIM-1, KIM1, TIM, TIM-1, TIM1, TIMD-1, TIMD1, hepatitis A virus cellular receptor 1, T cell immunoglobin domain and mucin domain protein 1, T-cell immunoglobulin mucin family member 1, T-cell immunoglobulin mucin receptor 1, T-cell membrane protein 1, kidney injury molecule 1
Species: human

Top Publications

  1. doi Kidney injury molecule 1 (Kim1) is a novel ciliary molecule and interactor of polycystin 2
    E Wolfgang Kuehn
    Renal Division, University Hospital Freiburg, Hugstetter Strasse 55, D 79106 Freiburg, Germany
    Biochem Biophys Res Commun 364:861-6. 2007
  2. pmc Regression of microalbuminuria in type 1 diabetes is associated with lower levels of urinary tubular injury biomarkers, kidney injury molecule-1, and N-acetyl-β-D-glucosaminidase
    Vishal S Vaidya
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Kidney Int 79:464-70. 2011
  3. ncbi Molecular variations in the promoter and coding regions of human Tim-1 gene and their association in Koreans with asthma
    Soo Cheon Chae
    Genomic Research Center for Immune Disorders, School of Medicine, Wonkwang University, Iksan, Chonbuk 570 749, Korea
    Hum Immunol 64:1177-82. 2003
  4. doi Kidney injury molecule-1 (KIM-1): a novel kidney-specific injury molecule playing potential double-edged functions in kidney injury
    Wenqian Huo
    Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China
    Transplant Rev (Orlando) 24:143-6. 2010
  5. ncbi Human TIM-1 associates with the TCR complex and up-regulates T cell activation signals
    Lauri L Binné
    Biogen Idec, 12 Cambridge Center, Cambridge, MA 02142, USA
    J Immunol 178:4342-50. 2007
  6. ncbi A functional polymorphism in the TIM-1 gene is associated with asthma in a Chinese Han population
    Qiji Liu
    Key Laboratory of Experimental Teratology, Ministry of Education, China, Institute of Medical Genetics, School of Medicine, Shandong University, Jinan, PR China
    Int Arch Allergy Immunol 144:197-202. 2007
  7. pmc High urinary excretion of kidney injury molecule-1 is an independent predictor of graft loss in renal transplant recipients
    Mirjan M van Timmeren
    Department of Pathology and Laboratory Medicine, University Medical Center Groningen and University of Groningen, The Netherlands
    Transplantation 84:1625-30. 2007
  8. doi TIM-1: a new player in transplant immunity
    Christophe Mariat
    The Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Transplantation 87:S84-6. 2009
  9. ncbi Insertion/deletion coding polymorphisms in hHAVcr-1 are not associated with atopic asthma in the Japanese population
    E Noguchi
    Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, Japan
    Genes Immun 4:170-3. 2003
  10. ncbi Genetic variants of the T-cell immunoglobulin mucin 1 but not the T-cell immunoglobulin mucin 3 gene are associated with asthma in an African American population
    Pei Song Gao
    Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Allergy Clin Immunol 115:982-8. 2005

Research Grants

  1. Amelioration of cisplatin ototoxicity by transplatin
    Debashree Mukherjea; Fiscal Year: 2010
  2. Sushrut S Waikar; Fiscal Year: 2015
  3. A Hybrid Katp Channel Opener to Prevent Radiocontrast-Induced Nephropathy
    Kanneganti Murthy; Fiscal Year: 2012
  4. Pharmacokinetic and Pharmacogenomic Determinants of Cisplatin Kidney Injury
    Melanie S Joy; Fiscal Year: 2013
  5. Low cost quantitative monitoring of kidney injury biomarkers using a glucometer
    Tian Lan; Fiscal Year: 2013
  6. Sushrut S Waikar; Fiscal Year: 2016
  7. Urinary Biomarkers for Recovery After Acute Kidney Injury and Prognosis in Hospit
    ISAAC ELI HALL; Fiscal Year: 2010
  8. MARK EDWARD WESTERMAN; Fiscal Year: 2014
  9. Biomarkers in Acute Kidney Injury
    Joseph Bonventre; Fiscal Year: 2009
  10. Chirag R Parikh; Fiscal Year: 2016

Detail Information

Publications282 found, 100 shown here

  1. doi Kidney injury molecule 1 (Kim1) is a novel ciliary molecule and interactor of polycystin 2
    E Wolfgang Kuehn
    Renal Division, University Hospital Freiburg, Hugstetter Strasse 55, D 79106 Freiburg, Germany
    Biochem Biophys Res Commun 364:861-6. 2007
    ..We have previously shown that overexpression of mutated forms of the chemosensor kidney injury molecule 1 (Kim1) abolishes the flow response in ciliated MDCK cells...
  2. pmc Regression of microalbuminuria in type 1 diabetes is associated with lower levels of urinary tubular injury biomarkers, kidney injury molecule-1, and N-acetyl-β-D-glucosaminidase
    Vishal S Vaidya
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Kidney Int 79:464-70. 2011
    ..Hence, tubular dysfunction is a critical component of the early course of diabetic nephropathy...
  3. ncbi Molecular variations in the promoter and coding regions of human Tim-1 gene and their association in Koreans with asthma
    Soo Cheon Chae
    Genomic Research Center for Immune Disorders, School of Medicine, Wonkwang University, Iksan, Chonbuk 570 749, Korea
    Hum Immunol 64:1177-82. 2003
    The family of T-cell immunoglobulin domain and mucin domain (TIM) proteins is identified to be expressed on T cells...
  4. doi Kidney injury molecule-1 (KIM-1): a novel kidney-specific injury molecule playing potential double-edged functions in kidney injury
    Wenqian Huo
    Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China
    Transplant Rev (Orlando) 24:143-6. 2010
    ..In this review, some of the known features and functions of KIM-1 are highlighted...
  5. ncbi Human TIM-1 associates with the TCR complex and up-regulates T cell activation signals
    Lauri L Binné
    Biogen Idec, 12 Cambridge Center, Cambridge, MA 02142, USA
    J Immunol 178:4342-50. 2007
    The T cell, Ig domain, and mucin domain-1 (TIM-1) gene is associated with Th2 T cell responses and human atopic diseases. The mechanism by which TIM-1 influences T cell responses remains unknown...
  6. ncbi A functional polymorphism in the TIM-1 gene is associated with asthma in a Chinese Han population
    Qiji Liu
    Key Laboratory of Experimental Teratology, Ministry of Education, China, Institute of Medical Genetics, School of Medicine, Shandong University, Jinan, PR China
    Int Arch Allergy Immunol 144:197-202. 2007
    b>TIM-1, a member of the T cell immunoglobulin and mucin domain (TIM) gene family was implicated as an asthma susceptibility gene in previous studies...
  7. pmc High urinary excretion of kidney injury molecule-1 is an independent predictor of graft loss in renal transplant recipients
    Mirjan M van Timmeren
    Department of Pathology and Laboratory Medicine, University Medical Center Groningen and University of Groningen, The Netherlands
    Transplantation 84:1625-30. 2007
    ..Urinary KIM-1 excretion has been quantified as biomarker of renal damage. We prospectively studied whether urinary KIM-1 predicts graft loss, independent of renal function and proteinuria...
  8. doi TIM-1: a new player in transplant immunity
    Christophe Mariat
    The Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Transplantation 87:S84-6. 2009
    Data have recently pointed to a possible regulatory function of T-cell immunoglobulin mucin protein 1 (TIM-1) during the alloimmune response...
  9. ncbi Insertion/deletion coding polymorphisms in hHAVcr-1 are not associated with atopic asthma in the Japanese population
    E Noguchi
    Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, Japan
    Genes Immun 4:170-3. 2003
    Hepatitis A virus receptor (HAVcr-1) and T-cell immunoglobulin- and mucin-domain-containing molecule (TIM)-3 were recently implicated as asthma susceptibility genes in the study of congenic mice...
  10. ncbi Genetic variants of the T-cell immunoglobulin mucin 1 but not the T-cell immunoglobulin mucin 3 gene are associated with asthma in an African American population
    Pei Song Gao
    Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Allergy Clin Immunol 115:982-8. 2005
    The T-cell immunoglobulin mucin ( TIM ) proteins and their genetic variants have been suggested to play a role in regulating allergic diseases.
  11. ncbi Inhibition of in vitro and in vivo T cell responses by recombinant human Tim-1 extracellular domain proteins
    Mehdi Mesri
    CuraGen Corporation, Branford, CT 06405, USA
    Int Immunol 18:473-84. 2006
    Members of the T cell, Ig domain and mucin domain (Tim) family of proteins have recently been implicated in the control of T cell-mediated immune responses...
  12. ncbi Absence of association between two insertion/deletion coding genetic polymorphisms of TIM-1 gene and asthma in Chinese Han population
    J S Li
    Institute of Medical Genetics, School of Medicine, Shandong University, Jinan, Shandong, China
    Int J Immunogenet 33:417-22. 2006
    b>TIM-1, a member of T-cell immunoglobulin domain and mucin domain (TIM) gene family, was implicated as an asthma susceptibility gene in previous studies...
  13. pmc Immunoglobulin A (IgA) is a natural ligand of hepatitis A virus cellular receptor 1 (HAVCR1), and the association of IgA with HAVCR1 enhances virus-receptor interactions
    Cecilia Tami
    Laboratory of Hepatitis and Related Emerging Agents, CBER, Food and Drug Administration, Bethesda, MD 20892, USA
    J Virol 81:3437-46. 2007
    The hepatitis A virus cellular receptor 1 (HAVCR1/TIM1), a member of the T-cell immunoglobulin mucin (TIM) family, is an important atopy susceptibility gene in humans...
  14. ncbi Expression of human TIM-1 and TIM-3 on lymphocytes from systemic lupus erythematosus patients
    Y Wang
    Institute of Immunology, Shandong University School of Medicine, Jinan, China
    Scand J Immunol 67:63-70. 2008
    ..b>TIM-3 is expressed on T helper type 1 (Th1) cells and implicated in the pathogenesis of Th1-driven auto- and allo-..
  15. pmc Assay validation for KIM-1: human urinary renal dysfunction biomarker
    Shalini Chaturvedi
    Department of Biomarker Services, Covance Central Laboratory Services Inc, 8211 SciCor Drive, Indianapolis, Indiana 46214 2985, USA
    Int J Biol Sci 5:128-34. 2009
    ..This is a robust assay to detect urinary levels of KIM-1, which serves as a non-invasive sensitive, reproducible, and potentially high-throughput method to detect early kidney injury in drug development studies...
  16. pmc The human homolog of HAVcr-1 codes for a hepatitis A virus cellular receptor
    D Feigelstock
    Laboratory of Hepatitis Viruses, Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Virol 72:6621-8. 1998
    The hepatitis A virus cellular receptor 1 (HAVcr-1) cDNA was isolated from a cDNA expression library of African green monkey kidney (AGMK) cells by using protective monoclonal antibody (MAb) 190/4, which blocks the binding of hepatitis A ..
  17. ncbi Shedding of kidney injury molecule-1, a putative adhesion protein involved in renal regeneration
    Veronique Bailly
    Biogen Inc, Cambridge, Massachusetts 02142, USA
    J Biol Chem 277:39739-48. 2002
    ....
  18. ncbi Ciliary calcium signaling is modulated by kidney injury molecule-1 (Kim1)
    Fruzsina Kotsis
    Department of Medicine, University Hospital Freiburg, Renal Unit, Hugstetter Str 55, Freiburg, Germany
    Pflugers Arch 453:819-29. 2007
    ..We show that a novel interactor of TRPP2, kidney injury molecule-1 (Kim1), which is expressed at low levels in the normal kidney and upregulated after ischemia, in renal cell cancer and in ..
  19. pmc T cell Ig and mucin domain-1-mediated T cell activation requires recruitment and activation of phosphoinositide 3-kinase
    Anjali J de Souza
    Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Immunol 180:6518-26. 2008
    Ligation of the transmembrane protein T cell Ig and mucin domain (Tim)-1 can costimulate T cell activation. Agonistic Abs to Tim-1 are also capable of inducing T cell activation without additional stimuli...
  20. doi Combination of urinary kidney injury molecule-1 and interleukin-18 as early biomarker for the diagnosis and progressive assessment of acute kidney injury following cardiopulmonary bypass surgery: a prospective nested case-control study
    Xin Ling Liang
    Division of Nephrology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, China
    Biomarkers 15:332-9. 2010
    ..The combination of these two biomarkers facilitates the early diagnosis and assessment of the likely progression of AKI after CPB...
  21. doi Urinary kidney injury molecule-1 in patients with IgA nephropathy is closely associated with disease severity
    Peng Cheng Xu
    Renal Division, Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China
    Nephrol Dial Transplant 26:3229-36. 2011
    ..Urinary kidney injury molecule-1 (KIM-1) is a sensitive biomarker for proximal tubule injury. The aim of the study is to investigate the value of KIM-1 as a biomarker for assessing the renal injury in IgAN...
  22. doi High urinary excretion of kidney injury molecule-1 is an independent predictor of end-stage renal disease in patients with IgA nephropathy
    Hilde P E Peters
    Department of Nephrology, Radboud University Nijmegen Medical Centre Nijmegen, Nijmegen, The Netherlands
    Nephrol Dial Transplant 26:3581-8. 2011
    ..We evaluated the prognostic value of these markers in patients with IgAN...
  23. pmc T-cell immunoglobulin and mucin domain 1 (TIM-1) is a receptor for Zaire Ebolavirus and Lake Victoria Marburgvirus
    Andrew S Kondratowicz
    Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 108:8426-31. 2011
    ..Here, we show that T-cell Ig and mucin domain 1 (TIM-1) binds to the receptor binding domain of the Zaire Ebola virus (EBOV) glycoprotein, and ectopic TIM-1 expression ..
  24. doi KIM-1 expression predicts renal outcomes in IgA nephropathy
    Soon Hyo Kwon
    Hyonam Kidney Laboratory, Dae Sa Gwan Ro 59, Hannam dong Yongsan gu, Seoul, Korea
    Clin Exp Nephrol 17:359-64. 2013
    ..We performed this study to determine whether tissue KIM-1 has clinical implications for predicting long-term outcome and whether urinary KIM-1 is correlated with tissue KIM-1 and kidney injury in IgAN patients...
  25. pmc Performance of kidney injury molecule-1 and liver fatty acid-binding protein and combined biomarkers of AKI after cardiac surgery
    Chirag R Parikh
    Program of Applied Translational Research, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Clin J Am Soc Nephrol 8:1079-88. 2013
    ..AKI is common and novel biomarkers may help provide earlier diagnosis and prognosis of AKI in the postoperative period...
  26. pmc The Cys-rich region of hepatitis A virus cellular receptor 1 is required for binding of hepatitis A virus and protective monoclonal antibody 190/4
    P Thompson
    Laboratory of Hepatitis Viruses, Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Virol 72:3751-61. 1998
    The hepatitis A virus cellular receptor 1 (HAVcr-1) cDNA codes for a class I integral membrane glycoprotein, termed havcr-1, of unknown natural function which serves as an African green monkey kidney (AGMK) cell receptor for HAV...
  27. ncbi TIM-1, a novel allergy and asthma susceptibility gene
    Jennifer J McIntire
    Division of Allergy and Immunology, Department of Pediatrics, Stanford University, CA 94305 5208, USA
    Springer Semin Immunopathol 25:335-48. 2004
    ..asthma, we simplified this complex trait and identified the novel T cell immunoglobulin domain, mucin-like domain (TIM) gene family, that encodes transmembrane proteins expressed by CD4 T cells...
  28. pmc TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells
    Norimoto Kobayashi
    Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Harvard Medical School, Boston, MA 02115, USA
    Immunity 27:927-40. 2007
    The T cell immunoglobulin mucin (TIM) proteins regulate T cell activation and tolerance...
  29. ncbi Kidney injury molecule-1 expression identifies proximal tubular injury in urate nephropathy
    Manish Nepal
    Department of Internal Medicine, William Beaumont Hospital, Royal Oak, MI 48073 6769, USA
    Ann Clin Lab Sci 38:210-4. 2008
    ..In their renal biopsies, we demonstrate upregulation of kidney injury molecule-1 (KIM-1), a specific injury marker, in proximal tubular cells. This finding implicates a role for proximal tubular injury in urate nephropathy...
  30. pmc Comparative analysis of urinary biomarkers for early detection of acute kidney injury following cardiopulmonary bypass
    Orfeas Liangos
    Division of Nephrology, Caritas St Elizabeth s Medical Center, Boston, MA 02135, USA
    Biomarkers 14:423-31. 2009
    ..006). In this small pilot cohort, KIM-1 performed best as an early biomarker for AKI. Larger studies are needed to explore further the role of biomarkers for early detection of AKI following cardiac surgery...
  31. ncbi The association of the exon 4 variations of Tim-1 gene with allergic diseases in a Korean population
    Soo Cheon Chae
    Genomic Research Center for Immune Disorders, School of Medicine, Wonkwang University, Iksan, Chonbuk, Republic of Korea
    Biochem Biophys Res Commun 312:346-50. 2003
    The family of T-cell immunoglobulin domain and mucin domain (TIM) proteins is identified to be expressed on T cells...
  32. ncbi Modulation of programmed cell death by medicinal plants
    U Thatte
    Department of Pharmacology and Therapeutics, Seth GS Medical College, Parel, Mumbai, India
    Cell Mol Biol (Noisy-le-grand) 46:199-214. 2000
    ..Hence, it is natural to assume that chemicals must exist in them to regulate programmed cell death in them. Thus, plants are likely to prove to be important sources of agents that will modulate programmed cell death...
  33. pmc Molecular imaging of the kidneys
    Zsolt Szabo
    Division of Nuclear Medicine, Department of Radiology, Johns Hopkins University School of Medicine, 601 N CarolineStreet, Baltimore, MD 21287, USA
    Semin Nucl Med 41:20-8. 2011
    ..Potential imaging targets are the kidney injury molecule 1, which is highly expressed in kidney injury and renal cancer but not in normal kidneys...
  34. doi Correlation between humoral and cellular immune responses and the expression of the hepatitis A receptor HAVcr-1 on T cells after hepatitis A re-vaccination in high and low-responder vaccinees
    Erika Garner-Spitzer
    Department of Specific Prophylaxis and Tropical Medicine, Center for Physiology, Pathophysiology and Immunology, Medical University of Vienna, Vienna, Austria
    Vaccine 27:197-204. 2009
    ....
  35. doi Mineralocorticoid receptor-mediated DNA damage in kidneys of DOCA-salt hypertensive rats
    Nicole Schupp
    Institute of Pharmacology and Toxicology, University of Wurzburg, 97078 Wurzburg, Germany
    FASEB J 25:968-78. 2011
    ..Our results suggest a mutagenic potential of high mineralocorticoid levels, frequent in hypertensive individuals...
  36. doi Kallikrein protects against microalbuminuria in experimental type I diabetes
    Sophie Bodin
    INSERM UMR 872, Centre de Recherche des Cordeliers, Paris, France
    Kidney Int 76:395-403. 2009
    ....
  37. doi Kidney injury molecule-1 expression in rat proximal tubule after treatment with segment-specific nephrotoxicants: a tool for early screening of potential kidney toxicity
    Arianna Chiusolo
    GlaxoSmithKline, Verona, Italy
    Toxicol Pathol 38:338-45. 2010
    ..In conclusion, this study suggested KIM-1 as a sensitive molecular marker of different levels of tubular injury, and it is likely to represent a potential tool for early screening of nephrotoxicants...
  38. doi Differential role of Rab proteins in ciliary trafficking: Rab23 regulates smoothened levels
    Christopher Boehlke
    Renal Unit, University Medical Center, University of Freiburg, Hugstetter Strasse 55, Freiburg 79106, Germany
    J Cell Sci 123:1460-7. 2010
    ..of the HH-associated transmembrane receptor Smoothened, the microtubular tip protein EB1, and the receptor protein Kim1. Ciliary FRAP confirmed the role of Rab8 in protein entry to the cilium...
  39. pmc Increased susceptibility of aging kidney to ischemic injury: identification of candidate genes changed during aging, but corrected by caloric restriction
    G Chen
    Department of Systems Biology and Translational Medicine, College of Medicine, Texas A and M University System Health Science Center, College Station, TX 77843 1114, USA
    Am J Physiol Renal Physiol 293:F1272-81. 2007
    ..In summary, we identified genes changed by aging and changes attenuated by caloric restriction. This will facilitate investigation into the molecular mechanism mediating the age-related increase in susceptibility to injury...
  40. pmc The interaction of hepatitis A virus (HAV) with soluble forms of its cellular receptor 1 (HAVCR1) share the physiological requirements of infectivity in cell culture
    Erica Silberstein
    Laboratory of Hepatitis and Related Emerging Agents, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, USA
    Virol J 6:175. 2009
    ..Here, we used HAV soluble receptor neutralization and alteration assays to study the requirements of the HAV-HAVCR1 interaction and to determine whether HAVCR1 is also a receptor for wt HAV...
  41. ncbi [Expression and clinical significance of kidney injury molecule-1 in renal epithelial neoplasms]
    Ying Chun Dong
    Department of Pathology, Clinical School of Medical College of Nanjing University Nanjing General Hospital of Nanjing Military Command, People s Liberation Army, China
    Zhonghua Bing Li Xue Za Zhi 39:35-9. 2010
    ..To study the expression and clinical significance of kidney injury molecule-1 (KIM-1) in primary and metastatic renal epithelial neoplasms...
  42. ncbi Impact of Japanese beetle (Coleoptera: Scarabaeidae) feeding on seashore paspalum
    S K Braman
    Department of Entomology, University of Georgia, College of Agricultural and Environmental Sciences, 1109 Experiment Street, Griffin, GA 30223 1797, USA
    J Econ Entomol 99:1699-704. 2006
    ..The paspalum cultivars that seemed most tolerant of grub feeding were '561-79', 'Sea Isle 2000', 'Durban', 'HI-10', 'Kim-1', 'Sea Dwarf', and 'Sea Spray'...
  43. pmc Urinary biomarkers in the early diagnosis of acute kidney injury
    W K Han
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Kidney Int 73:863-9. 2008
    ..Urinary MMP-9 was not a sensitive marker in the case-control study. Our results suggest that urinary biomarkers allow diagnosis of acute kidney injury earlier than a rise in serum creatinine...
  44. doi Novel aspects of pharmacological therapies for acute renal failure
    Ulrich Kunzendorf
    Division of Nephrology and Hypertension, University of Kiel, Kiel, Germany
    Drugs 70:1099-114. 2010
    ..In the future, these new approaches will enable us to extend our therapeutic repertoire...
  45. doi Identification of HAVCR1 gene haplotypes associated with mRNA expression levels and susceptibility to autoimmune diseases
    Jose Raul Garcia-Lozano
    Servicio de Inmunologia, Instituto de Biomedicina, Hospital Universitario Virgen del Rocio, Avda Manuel Siurot s n, 41013, Seville, Spain
    Hum Genet 128:221-9. 2010
    ..3 vs. 5.9% in controls, p = 0.0046, p (c) = 0.014, OR = 2.23, 95% CI 1.23-4.10). Our results support a relationship between HAVCR1 haplotypes and mRNA expression levels, and suggest an association of this gene with autoimmune diseases...
  46. doi Differential effect of cyclosporine and mycophenolic acid on the human regulatory T cells and TH-17 cells balance
    F Abadja
    Laboratoire de Nephrologie, EA3065, Université Jean Monnet, Saint Etienne, France
    Transplant Proc 41:3367-70. 2009
    ..We have investigated the effects of two immunosuppressive drugs, cyclosporine (CsA) and mycophenolic acid (MPA) on the development of Treg/TH-17 cell responses...
  47. pmc Transtympanic administration of short interfering (si)RNA for the NOX3 isoform of NADPH oxidase protects against cisplatin-induced hearing loss in the rat
    Debashree Mukherjea
    Department of Surgery, Southern Illinois University School of Medicine, Springfield, Illinois 62794 9649, USA
    Antioxid Redox Signal 13:589-98. 2010
    ..This appears to be the first study of the efficacy of transtympanic delivery of siRNA attenuating cisplatin ototoxicity...
  48. pmc Desferrithiocin analogue iron chelators: iron clearing efficiency, tissue distribution, and renal toxicity
    Raymond J Bergeron
    Department of Medicinal Chemistry, University of Florida, JHMHC, Box 100485, Gainesville, FL 32610 0485, USA
    Biometals 24:239-58. 2011
    ..Overall, the results suggest that 3 would be a far superior clinical candidate to 9...
  49. pmc Follistatin-like 1 regulates renal IL-1β expression in cisplatin nephrotoxicity
    Derek C Adams
    Department of Molecular Medicine, Maine Medical Center Research Institute, Scarborough, Maine 04074, USA
    Am J Physiol Renal Physiol 299:F1320-7. 2010
    ....
  50. doi Comparison of a static and a dynamic in vitro model to estimate the bioaccessibility of As, Cd, Pb and Hg from food reference materials Fucus sp. (IAEA-140/TM) and Lobster hepatopancreas (TORT-2)
    Silvia Torres-Escribano
    Instituto de Agroquimica y Tecnologia de Alimentos IATA CSIC, Apdo 73, 46100, Burjassot, Valencia, Spain
    Sci Total Environ 409:604-11. 2011
    ..using two in vitro gastrointestinal digestion methods: a static method (SM) and a dynamic multicompartment method (TIM-1). There are significant differences (p<0...
  51. ncbi Human membrane protein Tim-3 facilitates hepatitis A virus entry into target cells
    Lili Sui
    Institute of Immunology, Second Military Medical University, Shanghai, PR China
    Int J Mol Med 17:1093-9. 2006
    ..human dendritic cell (DC) cDNA library by large-scale random sequencing, which is identical to previously reported Tim-3 (T-cell Ig- and mucin-domain-containing molecule 3)...
  52. doi Evaluation of the sublingual microcirculation in cardiogenic shock
    Christian Jung
    Clinic of Internal Medicine I, Friedrich Schiller University, Jena, Germany
    Clin Hemorheol Microcirc 42:141-8. 2009
    ..We investigated the sublingual microcirculation in non-surgical patients admitted to our medical, intensive care unit (ICU)...
  53. ncbi SMUCKLER/TIM4 is a distinct member of TIM family expressed by stromal cells of secondary lymphoid tissues and associated with lymphotoxin signaling
    Alexander N Shakhov
    Basic Research Program, SAIC Frederick, Inc, National Cancer Institute, Frederick, USA
    Eur J Immunol 34:494-503. 2004
    ..Unlike TIM1 and TIM3, which were implicated in T cell-mediated functions, SMUCKLER lacks tyrosine phosphorylation motif in its ..
  54. pmc The TIM-1:TIM-4 pathway enhances renal ischemia-reperfusion injury
    Song Rong
    Transplant Center, University Hospital Munich, Marchioninistrasse 15, Munich, Germany
    J Am Soc Nephrol 22:484-95. 2011
    ..The TIM-1:TIM-4 pathway participates in the activation/differentiation of CD4+ T cells, suggesting that it may modulate ..
  55. ncbi Mineralocorticoid receptor blockade confers renoprotection in preexisting chronic cyclosporine nephrotoxicity
    Jazmin Pérez-Rojas
    Molecular Physiology Unit, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico
    Am J Physiol Renal Physiol 292:F131-9. 2007
    ..fibrosis, arteriolar thickening, glomerular diameter, apoptosis index and TGF-beta, procaspase-3, and kidney injury molecule 1 (Kim-1) mRNA levels as well as Kim-1 shedding in urine were evaluated...
  56. pmc Kidney injury molecule-1 is an early biomarker of cadmium nephrotoxicity
    W C Prozialeck
    Department of Pharmacology, Midwestern University, Downers Grove, Illinois 60515, USA
    Kidney Int 72:985-93. 2007
    ..Immunohistochemical analysis showed that Kim-1 was present in proximal tubule cells of the Cd-treated rats. Our results suggest that Kim-1 may be a useful biomarker of early stages of Cd-induced proximal tubule injury...
  57. pmc Comparison of kidney injury molecule-1 and other nephrotoxicity biomarkers in urine and kidney following acute exposure to gentamicin, mercury, and chromium
    Yuzhao Zhou
    Center for Devices and Radiological Health, U S Food and Drug Administration, White Oak Life Sciences Laboratory, Silver Spring, MD 20993, USA
    Toxicol Sci 101:159-70. 2008
    ..Urinary Kim-1 and kidney Kim-1/Havcr1 expression appear to be sensitive and tissue-specific biomarkers that will improve detection of early acute kidney injury following exposure to nephrotoxic chemicals and drugs...
  58. pmc Reduction of proteinuria in adriamycin-induced nephropathy is associated with reduction of renal kidney injury molecule (Kim-1) over time
    Andrea B Kramer
    Department of Pathology and Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Physiol Renal Physiol 296:F1136-45. 2009
    ....
  59. pmc Gene-trap mutagenesis identifies mammalian genes contributing to intoxication by Clostridium perfringens ε-toxin
    Susan E Ivie
    Division of Infectious Disease, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
    PLoS ONE 6:e17787. 2011
    ..Gene expression microarray analysis revealed that one of the identified genes, hepatitis A virus cellular receptor 1 (HAVCR1, KIM-1, TIM1), is more abundantly expressed in human kidney cell lines than it is ..
  60. doi Clinical implication of urinary neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 in patients with acute paraquat intoxication
    Hyo Wook Gil
    Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan City, Republic of Korea
    Clin Toxicol (Phila) 47:870-5. 2009
    ..We prospectively investigated changes in urinary kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) in acute PQ intoxication...
  61. ncbi Evidence for natural selection in the HAVCR1 gene: high degree of amino-acid variability in the mucin domain of human HAVCR1 protein
    T Nakajima
    Division of Genetic Diagnosis, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Genes Immun 6:398-406. 2005
    ..Here, we report three unusual patterns of genetic variation in the human hepatitis A virus cellular receptor 1 gene (HAVCR1) that are similar to patterns observed in major histocompatibility complex loci...
  62. ncbi Association of atopy and eczema with polymorphisms in T-cell immunoglobulin domain and mucin domain-IL-2-inducible T-cell kinase gene cluster in chromosome 5 q 33
    Penelope E Graves
    Arizona Respiratory Center, University of Arizona, Tuscon, AZ 85724 5030, USA
    J Allergy Clin Immunol 116:650-6. 2005
    The T-cell immunoglobulin domain and mucin domain (TIM) gene family and the gene for IL-2-inducible T-cell kinase (ITK), located in chromosome 5 q 33 and potentially involved in the T-cell proliferation and differentiation, are good ..
  63. pmc Vaccination with cell immunoglobulin mucin-1 antibodies and inactivated influenza enhances vaccine-specific lymphocyte proliferation, interferon-gamma production and cross-strain reactivity
    W Soo Hoo
    Telos Pharmaceuticals LLC, San Diego, CA 92131, USA
    Clin Exp Immunol 145:123-9. 2006
    ..We present evidence that antibodies against T cell immunoglobulin mucin-1 (TIM-1), a recently identified immunomodulatory molecule, stimulate cellular immunity against influenza viruses and ..
  64. ncbi High expression of insulin-like growth factor binding protein-3 is correlated with lower portal invasion and better prognosis in human hepatocellular carcinoma
    Shinichi Aishima
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Sci 97:1182-90. 2006
    ..Low expression of IGFBP-3 was independently associated with poor survival. IGFBP-3 could be a molecular target of intrinsic importance for further development of novel therapeutic strategy against HCC...
  65. pmc Molecular and phylogenetic analyses reveal mammalian-like clockwork in the honey bee (Apis mellifera) and shed new light on the molecular evolution of the circadian clock
    Elad B Rubin
    Department of Evolution, Systematics, and Ecology, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Genome Res 16:1352-65. 2006
    ..The honey bee genome does not encode an ortholog of Drosophila Timeless (Tim1), has only the mammalian type Cryptochrome (Cry-m), and has a single ortholog for each of the other canonical "..
  66. doi Disruption of T-cell immunoglobulin and mucin domain molecule (TIM)-1/TIM4 interaction as a therapeutic strategy in a dendritic cell-induced peanut allergy model
    Bai Sui Feng
    Brain Body Institute, McMaster University, Hamilton, Ontario, Canada
    J Allergy Clin Immunol 122:55-61, 61.e1-7. 2008
    Recent reports indicate that dendritic cell (DC)-derived T-cell immunoglobulin and mucin domain molecule (TIM)-4 plays an important role in the initiation of T(H)2 polarization...
  67. pmc Urinary biomarkers in the early detection of acute kidney injury after cardiac surgery
    Won K Han
    Thomas Jefferson University Hospital, Department of Medicine, Jefferson Medical School, Philadelphia, Pennsylvania 19107, USA
    Clin J Am Soc Nephrol 4:873-82. 2009
    ..Receiver-operating characteristic curves were generated and the areas under the curve (AUCs) compared for performance of biomarkers in detection of postoperative AKI...
  68. pmc Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells
    Xueli Yuan
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital and Children s Hospital Boston and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:10734-9. 2009
    ..impact of targeting a T cell-co-stimulatory pathway, and demonstrate that targeting T cell Ig and mucin domain-1 (Tim-1) with anti-Tim-1 overcomes this resistance by specifically inhibiting the pathogenic IL-17-producing CD8 T17 ..
  69. doi Identification of genes involved in gentamicin-induced nephrotoxicity in rats--a toxicogenomic investigation
    N Ozaki
    Department of Molecular and Cellular Biology, Kobe Pharma Research Institute, Nippon Boehringer Ingelheim Co, Ltd 6 7 5, Minatojima minamimachi Chuo ku, Kobe, Hyogo 650 0047, Japan
    Exp Toxicol Pathol 62:555-66. 2010
    ..The results of the study show the potential of microarray technology to study a complex mechanism of toxicity in a single study...
  70. doi Urinary L-FABP and anaemia: distinct roles of urinary markers in type 2 diabetes
    M von Eynatten
    Technical University Munich, Munich, Germany
    Eur J Clin Invest 40:95-102. 2010
    ..We studied the clinical significance of urinary L-FABP, KIM-1 and N-acetyl-beta-glucosaminidase (NAG) as potential markers of renal function and chronic ischaemic injury in patients with diabetic nephropathy...
  71. doi Evaluation of the usefulness of urinary biomarkers for nephrotoxicity in rats
    Yutaka Tonomura
    Drug Safety Evaluation, Developmental Research Laboratories, Shionogi and Co, Ltd, Toyonaka, Osaka, Japan
    Toxicology 273:53-9. 2010
    ..Therefore, combinatorial measurement of these biomarkers may be a powerful tool for highly effective screening of nephrotoxicity...
  72. doi Urinary levels of regenerating islet-derived protein III β and gelsolin differentiate gentamicin from cisplatin-induced acute kidney injury in rats
    Laura Ferreira
    Unidad de Investigacion, Hospital Universitario de Salamanca, Salamanca, Spain
    Kidney Int 79:518-28. 2011
    ..early diagnosis, for which a new generation of urine biomarkers is currently under development including kidney injury molecule 1 and neutrophil gelatinase-associated lipocalin...
  73. ncbi Heat shock protein expression is highly sensitive to ischemia-reperfusion injury in rat kidneys
    Ping L Zhang
    Division of Laboratory Medicine, Geisinger Medical Center, Danville, Pennsylvania, USA
    Ann Clin Lab Sci 38:57-64. 2008
    ....
  74. doi Transcriptomic analysis of nephrotoxicity induced by cephaloridine, a representative cephalosporin antibiotic
    Masatomo Rokushima
    Discovery Research Laboratories, Shionogi and Co, Ltd, 12 4, Sagisu 5 Chome, Fukushima ku, Osaka 553 0002, Japan
    Chem Res Toxicol 21:1186-96. 2008
    ..Among the candidate gene biomarkers, kidney injury molecule 1 was markedly upregulated at the mildly toxic dose, suggesting that this gene can be used as an early and ..
  75. pmc Differences in immunolocalization of Kim-1, RPA-1, and RPA-2 in kidneys of gentamicin-, cisplatin-, and valproic acid-treated rats: potential role of iNOS and nitrotyrosine
    Jun Zhang
    Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993 0002, USA
    Toxicol Pathol 37:629-43. 2009
    ..These findings suggest that peroxynitrite formation may be involved in the pathogenesis of Gen and Cis nephrotoxicity and that Kim-1, RPA-1, and RPA-2 have the potential to serve as site-specific biomarkers for Gen or Cis AKI...
  76. ncbi Expression and activation of apoptosis-related molecules involved in interferon-alpha-mediated apoptosis in human liver cancer cells
    Hirohisa Yano
    Department of Pathology, Kurume University School of Medicine, Research Center of Innovative Cancer Therapy of the 21st Century COE Program for Medical Science, Kurume, Fukuoka 830 0011, Japan
    Int J Oncol 26:1645-52. 2005
    ..In conclusion, our results suggest IFN-alpha-mediated apoptosis in liver cancer cells involves the mitochondrial apoptotic pathway and is induced by activating various caspases...
  77. ncbi Induction of kidney injury molecule-1 in homozygous Ren2 rats is attenuated by blockade of the renin-angiotensin system or p38 MAP kinase
    Martin H de Borst
    Dept of Pathology and Laboratory Medicine, Univ Medical Center Groningen and Univ of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Am J Physiol Renal Physiol 292:F313-20. 2007
    ..01). Kim-1 is associated with development of RAS-mediated renal damage. Antifibrotic treatment through RAS blockade or p38 MAP kinase inhibition reduced Kim-1 in the homozygous Ren2 model...
  78. ncbi Epitope-dependent effect of anti-murine TIM-1 monoclonal antibodies on T cell activity and lung immune responses
    Irene D Sizing
    Biogen Idec Incorporated, Cambridge, MA 02142, USA
    J Immunol 178:2249-61. 2007
    The TAPR locus containing the TIM gene family is implicated in the development of atopic inflammation in mouse, and TIM-1 allelic variation has been associated with the incidence of atopy in human patient populations...
  79. doi Proteomics for the investigation of acute kidney injury
    Prasad Devarajan
    Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
    Contrib Nephrol 160:1-16. 2008
    ..Based on the differential expression of the biomarkers, it is also likely that the AKI panels will distinguish between the various etiologies of AKI, and predict clinical outcomes...
  80. pmc A rapid urine test for early detection of kidney injury
    Vishal S Vaidya
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Kidney Int 76:108-14. 2009
    ....
  81. doi Quantitative analyses of kidney injury molecule-1 messenger RNA in kidney transplant recipients with graft dysfunction
    A L Nogare
    Division of Nephrology, Hospital de Clínicas de Porto Alegre and Post Graduate Medical Sciences Course, School of Medicine, Federal University of Rio Grande do Sul, Ramiro Barcelos Avenue, Porto Alegre, RS 90035 903 Brazil
    Transplant Proc 42:473-4. 2010
    ..We evaluated mRNA transcription of the KIM-1 gene in renal tissue of kidney transplant patients who were experiencing graft dysfunction searching for an accurate biomarker of kidney graft injury...
  82. pmc Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies
    Vishal S Vaidya
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Biotechnol 28:478-85. 2010
    ..This should enable early identification and elimination of compounds that are potentially nephrotoxic...
  83. doi Nephrotoxicity of mercuric chloride, methylmercury and cinnabar-containing Zhu-Sha-An-Shen-Wan in rats
    Jing Zhen Shi
    Guiyang Traditional Medical College, Guiyang, China
    Toxicol Lett 200:194-200. 2011
    ..In contrast, the expression of N-cadherin was decreased by HgCl(2). Thus, ZSASW and cinnabar are much less nephrotoxic than HgCl(2) and MeHg, indicating that chemical forms of mercury underlie their disposition and toxicity...
  84. pmc Biomarkers for drug-induced renal damage and nephrotoxicity-an overview for applied toxicology
    Tobias Christian Fuchs
    Toxicology, Merck Serono, Darmstadt, Germany
    AAPS J 13:615-31. 2011
    ..This review will give an overview of traditional and novel tools for the detection of renal damage...
  85. doi The effect of normothermic recirculation before cold preservation on post-transplant injury of ischemically damaged donor kidneys
    Cyril Moers
    Surgery Research Laboratory, Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Transpl Int 25:210-7. 2012
    ..We found that NR had no significant influence on any of these markers. Therefore, we conclude that this animal study by no means supports the presumed beneficial effect of NR on kidneys that have been severely damaged by warm ischemia...
  86. ncbi Proximal tubular renal dysfunction or damage in HIV-infected patients
    María Del Palacio
    Department of Infectious Diseases, Hospital Ramon y Cajal, Madrid, Spain
    AIDS Rev 14:179-87. 2012
    ..Here, we review the current knowledge on tubular toxicity in HIV-infected patients on antiretroviral therapy...
  87. ncbi Biomarkers for acute kidney injury in critically ill patients
    F Gonzalez
    Unit of Medical and Surgical Intensive Care Medicine, Avicenne Teaching Hospital, Bobigny, France
    Minerva Anestesiol 78:1394-403. 2012
    ..Cystatin C, neutrophil gelatinase-associated lipocalin, interleukin-18, fatty acid-binding proteins and kidney injury molecule 1 seem to be more accurate markers for AKI as compared with the traditional serum creatinine...
  88. doi Acute kidney injury in patients undergoing cardiac surgery
    Giuseppe Coppolino
    Nephrology Unit, Magna Graecia University, Catanzaro, Italy
    J Nephrol 26:32-40. 2013
    ..The occurrence of oliguria despite adequate cardiovascular therapy can be managed with furosemide, possibly using continuous infusion, or renal replacement therapy...
  89. doi Urinary tubular protein-based biomarkers in the rodent model of cisplatin nephrotoxicity: a comparative analysis of serum creatinine, renal histology, and urinary KIM-1, NGAL, and NAG in the initiation, maintenance, and recovery phases of acute kidney inj
    Vikash Sinha
    Nephrology Section, Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Investig Med 61:564-8. 2013
    ..Several biomarkers are becoming available for the early detection of acute kidney injury (AKI), but few have been directly compared...
  90. doi Tissue expression and correlation of a panel of urinary biomarkers following cisplatin-induced kidney injury
    Rebecca M Wadey
    1School of BioSciences, Cardiff University, Cardiff, Wales, UK
    Toxicol Pathol 42:591-602. 2014
    ..Future studies are needed to determine the wider application of these two markers for detecting renal toxicity following administration of other nephrotoxicants. ..
  91. pmc Impaired renal function and development in Belgrade rats
    Tania Veuthey
    Dept of Genetics and Complex Diseases, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115
    Am J Physiol Renal Physiol 306:F333-43. 2014
    ..These results further implicate an important role for the transporter in kidney function not only in iron reabsorption but also in glomerular filtration of the serum protein. ..
  92. doi Time-series pattern of gene expression profile in gentamycin-induced nephrotoxicity
    Yunliang Qiu
    National Shanghai Center for New Drug Safety Evaluation and Research, Shanghai, China and
    Toxicol Mech Methods 24:142-50. 2014
    ..In conclusion, the authors mapped the time-series gene expression patterns at the initiation, development and recovery stage of gentamycin-induced nephrotoxicity...
  93. doi Kidney injury molecule (KIM)-1 is associated with insulin resistance: results from two community-based studies of elderly individuals
    Axel C Carlsson
    Centre for Family Medicine, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden Electronic address
    Diabetes Res Clin Pract 103:516-21. 2014
    ..Urinary kidney injury molecule 1 (KIM-1) is a novel, highly specific marker of kidney tubular damage...
  94. pmc Characterizing functional domains for TIM-mediated enveloped virus entry
    Sven Moller-Tank
    Department of Microbiology, University of Iowa, Iowa City, Iowa, USA
    J Virol 88:6702-13. 2014
    T-cell immunoglobulin and mucin domain 1 (TIM-1) and other TIM family members were recently identified as phosphatidylserine (PtdSer)-mediated virus entry-enhancing receptors (PVEERs)...
  95. pmc Penalized count data regression with application to hospital stay after pediatric cardiac surgery
    Zhu Wang
    Department of Research, Connecticut Children s Medical Center, Hartford, CT, USA
    Stat Methods Med Res 25:2685-2703. 2016
    ..Applying the proposed methods to the aforementioned data, it is discovered that early postoperative urine biomarkers including NGAL, IL18, and KIM-1 independently predict LOS, after adjusting for risk and biomarker variables...
  96. pmc Accelerated receptor shedding inhibits kidney injury molecule-1 (KIM-1)-mediated efferocytosis
    Rushi Gandhi
    Department of Microbiology and Immunology, Western University, London, Ontario, Canada Matthew Mailing Centre for Translational Transplant Studies, Lawson Health Research Institute, London, Ontario, Canada
    Am J Physiol Renal Physiol 307:F205-21. 2014
    ..Our results suggest that KIM-1 shedding is accelerated by worsening cellular injury, and excess soluble KIM-1 competitively inhibits efferocytosis. These findings may be important in AKI when there is severe cellular injury. ..
  97. pmc Characterization of kidney injury molecule-1 in cats
    S K Bland
    Department of Pathobiology, University of Guelph, Guelph, ON
    J Vet Intern Med 28:1454-64. 2014
    ..Sensitive markers for detecting kidney injury are lacking. Kidney injury molecule 1 (KIM-1) is a useful biomarker of kidney injury in humans and rodents.
  98. doi Chronic exposure to nanoparticulate TiO2 causes renal fibrosis involving activation of the Wnt pathway in mouse kidney
    Fashui Hong
    School of Life Science, Huaiyin Normal University, Huaian 223300, China
    J Agric Food Chem 63:1639-47. 2015
    ..03 ± 0.01- to 2.73 ± 0.28-fold) and EMT markers Colla1, Fn, Twist, and α-SMA (0.06 ± 0.02- to 5.80 ± 0.61-fold). These findings indicate that nano-TiO2 induced renal fibrosis that may be mediated via Wnt signaling...
  99. doi Development of progressive albuminuria in male Munich Wistar Frömter rats is androgen dependent
    Laura Herlan
    Department of Clinical Pharmacology and Toxicology, Charité Centrum für Therapieforschung, Charite Universitatsmedizin Berlin, Berlin, Germany
    Physiol Genomics 47:281-9. 2015
    ..01) and similar to age-matched female MWF. The mRNA expression of renal tubular injury markers Kim1 and NGAL was increased in MWF Sham compared with Wistar Sham (P < 0...
  100. pmc Negative Regulation of TGFβ Signaling by Stem Cell Antigen-1 Protects against Ischemic Acute Kidney Injury
    TROY D CAMARATA
    Leukocyte Biology and Inflammation Program, Renal Division and Department of Medicine Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
    PLoS ONE 10:e0129561. 2015
    ..These studies demonstrate that by normally repressing TGFβ-mediated canonical Smad signaling, Sca-1 plays an important in renal epithelial cell homeostasis and in recovery of renal function following ischemic acute kidney injury. ..
  101. pmc Molecular Markers of Tubulointerstitial Fibrosis and Tubular Cell Damage in Patients with Chronic Kidney Disease
    Shunsaku Nakagawa
    Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Sakyo ku, Kyoto, 606 8507, Japan
    PLoS ONE 10:e0136994. 2015
    ..The results indicated that hepatitis A virus cellular receptor 1 (also known as Kidney Injury Molecule-1, KIM-1), lipocalin 2 (also known as neutrophil gelatinase-..

Research Grants70

  1. Amelioration of cisplatin ototoxicity by transplatin
    Debashree Mukherjea; Fiscal Year: 2010
    ..induction of stress proteins such as transient receptor potential vanilloid receptor 1 (TRPV1) and kidney injury molecule 1 (KIM-1). Importantly, transplatin did not inhibit the killing of prostate cancer cells by cisplatin...
  2. Sushrut S Waikar; Fiscal Year: 2015
    ..Urine, plasma, and DNA samples will be shared with the Consortium for future studies. ..
  3. A Hybrid Katp Channel Opener to Prevent Radiocontrast-Induced Nephropathy
    Kanneganti Murthy; Fiscal Year: 2012
    ..We now propose to test this agent in a clinically-relevant small animal model of radiocontrast-induced kidney failure. ..
  4. Pharmacokinetic and Pharmacogenomic Determinants of Cisplatin Kidney Injury
    Melanie S Joy; Fiscal Year: 2013
    ....
  5. Low cost quantitative monitoring of kidney injury biomarkers using a glucometer
    Tian Lan; Fiscal Year: 2013
    ..We believe this product can greatly increase the quality of life for post-transplant patient as well as reduce the associated costs for kidney failure and dysfunction. ..
  6. Sushrut S Waikar; Fiscal Year: 2016
    ..The identification of clinically useful CKD biomarkers will improve the care of individuals with and at risk for CKD. ..
  7. Urinary Biomarkers for Recovery After Acute Kidney Injury and Prognosis in Hospit
    ISAAC ELI HALL; Fiscal Year: 2010
    ..This study aims to identify, at the earliest possible time point, which patients are most likely to have complications related to kidney injury in order to provide safer care and reduce the potential for greater injury in the hospital. ..
  8. MARK EDWARD WESTERMAN; Fiscal Year: 2014
    ....
  9. Biomarkers in Acute Kidney Injury
    Joseph Bonventre; Fiscal Year: 2009
    ..The identification of early biomarkers of AKI will be a major step forward in the clinical care of patients at risk for AKI and will tremendously aid research on novel strategies for its prevention and treatment. ..
  10. Chirag R Parikh; Fiscal Year: 2016
    ..Aim 2: To construct a multi-marker biomarker panel to improve risk prediction of outcomes in adults and children. ..
  11. "Validation of Novel CKD Biomarkers in CRIC"
    Kathleen D Liu; Fiscal Year: 2013
    ....
  12. Subclinical and clinical heart disease and the effect on kidney injury and diseas
    Meyeon Park; Fiscal Year: 2013
    ..Detection and characterization of kidney disease by biomarkers of kidney injury may become an important tool for future management strategies in this setting and others. ..
  13. Leonard P Rybak; Fiscal Year: 2016
    ..Cisplatin causes hearing loss in a large percentage of cancer patients who receive this drug to cure their cancer. ..
  14. Role of Epithelial Chemokines in Kidney Injury-Molecule-1 Induced Renal Fibrosis
    Benjamin D Humphreys; Fiscal Year: 2010
    ..The proposed studies are therefore of great public health interest. ..
  15. Kidney Injury Molecule-1 in Renal Fibrosis
    Benjamin D Humphreys; Fiscal Year: 2010
    ..These studies could validate Kim-1 as a therapeutic target in renal fibrosis and are therefore of great public health interest. ..
  16. JOSEPH VINCENT BONVENTRE; Fiscal Year: 2016
    ....
  17. Technology and Endothelial Biology of Kidney Injury Molecule-1
    Vishal S Vaidya; Fiscal Year: 2010
    ..abstract_text> ..
  18. CHRISTOPHER O BRIAN PHILLIPS; Fiscal Year: 2014
    ....
  19. JOSEPH VINCENT BONVENTRE; Fiscal Year: 2016
    ..We will explore a potential synergy between autophagy, SIRT2, and cell cycle arrest-associated secretion. This work will hopefully identify new targets for enhancing adaptive repair and inhibiting pro-fibrotic repair. ..
  20. Xueying Zhao; Fiscal Year: 2014
    ..Our studies will also shed light on KIM-1/KIM-MPs as attractive targets for kidney disease management. ..
  21. Radiocontrast Nephropathy: Redox Degradation Catalyst and Nitric Oxide Donor
    ZSUZSANNA KINGA ZSENGELLER; Fiscal Year: 2013
    ..The proposed studies will provide a rational foundation for advanced commercial development of R-100, with the intent that this product will serve as first-line prophylaxis in high-risk diabeic patients undergoing CM injection. ..
  22. DAVID EVAN LEAF; Fiscal Year: 2014
    ..We will test the hypothesis that elevated plasma FGF23 levels are an independent predictor of the composite clinical outcome of mortality or sustained kidney injury 90 days following cardiac surgery. ..
  23. ANDREW DAVID RULE; Fiscal Year: 2016
    ..Aim 2. To test the hypothesis that 10 novel serum and urine biomarkers for CKD (e.g., kidney injury molecule 1) associate with age-related changes A) in decreased renal cortical volume and focal scarring by CT scan (..
  24. CRAIG ROBERT BROOKS; Fiscal Year: 2016
    ..The findings from this study will shed light on the role of Kim-1 in acute and chronic kidney injury, as well as highlight the potential therapeutic benefits of modulating Kim-1 function in kidney injury. ..
  25. Kim-1 regulation of autophagy and MHC presentation in kidney injury
    CRAIG ROBERT BROOKS; Fiscal Year: 2012
    ..We will determine how Kim-1 regulates autophagy and whether this autophagy contributes to the inflammation observed in kidney injury as well as identifies potential targets for therapeutic intervention. ..
  26. W Ray Kim; Fiscal Year: 2015
    ....
  27. Harvard Center of Polycystic Kidney Disease Research
    Jing Zhou; Fiscal Year: 2009
    ..Each of these projects will be supported by a Core facility that will provide most up to date support on molecular imaging and an administrative Core. ..
  28. Andrzej S Krolewski; Fiscal Year: 2016
    ..abstract_text> ..
  29. Comparative Evaluation of Urinary Biological Markers for the Prognostic Stratific
    Bertrand Jaber; Fiscal Year: 2009
    ....
  30. GORDON JAMES FREEMAN; Fiscal Year: 2014
    The overall goal of these studies is to understand how the HM genes regulate immune responses. The TIM gene family, discovered by our group in 2001 using a positional cloning strategy in congenic mice, potently regulates innate and ..
  31. Role of Novel T Cell Costimulatory Pathways in Allograft Rejection and Tolerance
    Mohamed H Sayegh; Fiscal Year: 2011
    The T cell immunoglobulin mucin (TIM) family of novel receptor-ligand pairs plays important roles in T cell activation, differentiation and effector/memory function, and in regulation of immune responses in autoimmunity and allergy/..
  32. Biomarkers in Acute Kidney Injury
    Joseph Bonventre; Fiscal Year: 2006
    ..The identification of early biomarkers of AKI will be a major step forward in the clinical care of patients at risk for AKI and will tremendously aid research on novel strategies for its prevention and treatment. ..
  33. Sheng Xiao; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): The T cell immunoglobulin and mucin domain (Tim) family of proteins have important and broad immune functions...
  34. Mechanisms of B Cell-Dependent Transplantation Tolerance
    James F Markmann; Fiscal Year: 2011
    ..We will also assess the contribution of the T cell Immunoglobulin and Mucin domain containing molecules (TIM-1 and TIM-4) to B cell-dependent tolerance and will apply a novel set of transgenic lines deficient in TIM-1 and ..
  35. Sharof M Tugizov; Fiscal Year: 2016
    ..HIV-associated phosphatidylserine (PS) interaction with the PS receptor T-cell immunoglobulin and mucin domain 1 (TIM-1) may facilitate cell-free viral transcytosis through the neonatal/infant oral mucosal epithelium...
  36. James F Markmann; Fiscal Year: 2016
    ..the contribution of the costimulatory molecule TIM-1 to tolerance induced by anti-CD45RB and will rely on a new TIM1-/- line generated by our collaborator, Dr Terry Strom...
  37. Role of B7 costimulation in induction and regulation of EAE
    Vijay K Kuchroo; Fiscal Year: 2012
    ..can provide a potent costimulatory signal for T and B cell activation, but other pathways like ICOS:ICOSL and TIM-1:Tim-1L pathways also play important roles in CD4+ T cell activation, differentiation, and effector function...
  38. Signaling and Cell Biology of TIM-1
    Lawrence P Kane; Fiscal Year: 2013
    ..The founding member of the family, TIM-1, was first described as a receptor for the hepatitis A virus (HAVcr-1)...
  39. WENDY JEAN MAURY; Fiscal Year: 2014
    ..This submission is designed to help fill this knowledge gap. We have identified that the surface protein TIM-1 serves as a cellular receptor for filoviruses on epithelial cells...
  40. GORDON JAMES FREEMAN; Fiscal Year: 2014
    The TIM gene family was identified using a congenic mouse model in which polymorphisms in TIM-1 and TIM-3 were associated with differences in Th1-Th2 differentiation and allergen-induced airway hyperreactivity (AHR) between BALB/c and ..
  41. Laurence A Turka; Fiscal Year: 2015
    ..Tc and Th1 responses, and second, we will investigate the role of CD28 (using CD28-conditional mice) and the novel Tim-1 pathway (using blocking Abs) in promoting T17 responses...
  42. Heidi Yeh; Fiscal Year: 2016
    ..The combination of anti-CD45RB and anti-TIM1 results in almost 100% long term islet allograft survival, and this effect is dependent on the presence of ..
  43. David M Rothstein; Fiscal Year: 2016
    ..T cell Ig Mucin protein-1 helps regulate Th differentiation. Anti- TIM-1 (RMT1-10) induces allograft tolerance thought to be Th2 dependent...
  44. KOKI MORIZONO; Fiscal Year: 2016
    ..We found that HIV replication is also drastically enhanced by one specific type of phosphatidylserine receptor, TIM-1, which is expressed on CD4-positive cells...
  45. KIDNEY INJURY MOLECULE-1 IN RENAL INJURY AND REPAIR
    Zhiwei Zhang; Fiscal Year: 2003
    ..This will help us to better understand the cellular and molecular mechanism involved in renal proximal tubular injury and repair processes and may ultimately lead to new diagnostic and therapeutic approaches in ARF. ..
  46. Kim-1 in Renal Epithelial Cell Motility and Adhesion
    BENJAMIN HUMPHREYS; Fiscal Year: 2005
    ..The proposed studies will have great relevance in understanding the molecular mechanisms of renal regeneration and renal cell cancer invasion and metastasis. ..
  47. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    Roselynn Rodriguez Manzanet; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The role members of the T cell, immunoglobulin domain, mucin domain (Tim) family of proteins play in immunity is quickly unfolding...
  48. MECHANISMS OF CADMIUM TOXICITY IN EPITHELIAL CELLS
    WALTER PROZIALECK; Fiscal Year: 2007
    ..Furthermore, the results of these studies could have more general implications regarding the mechanisms by which toxic substances affect living organisms. ..
  49. Roles of KIM-1 in Renal Injury and Repair
    WON HAN; Fiscal Year: 2007
    ..abstract_text> ..
  50. TWO NOVEL CPLA2 BINDING PROTEINS AND CELL DEATH
    JOSEPH VINCENT BONVENTRE; Fiscal Year: 2010
    ..Given the large number of patients that are initiated on dialysis each year, this addresses a critical public health problem. ..
  51. BIOCHEMICAL TOXICOLOGY AND MOLECULAR STRESS RESPONSES
    Takaharu Ichimura; Fiscal Year: 2004
    ..An initial prototype compound that is effective in inducing stress response genes and tolerance to injury in vitro and in vivo has been developed as part of the application. ..
  52. FLT3-LIGAND, IMMUNOMODULATION AND THERAPY IN ASTHMA
    DEVENDRA AGRAWAL; Fiscal Year: 2008
    ..The long-term goal of this study is to better define the potential mechanisms of action of FL to prevent and reverse allergic airway inflammation and associated changes in pulmonary function. ..
  53. TGF-BETA, CHLORIDE CHANNELS AND APOPTOSIS OF AIRWAY EPITHELIAL CELLS
    Devendra K Agrawal; Fiscal Year: 2010
    ..Such investigations would provide unique insights to the pathophysiologic process of chronic asthma and the means to prevent or reverse the disease. ..
  54. Heterogeneity among human CD4 T lymphocytes
    Dale T Umetsu; Fiscal Year: 2010
    ..We are proposing new paradigms for the pathogenesis of asthma, and these new paradigms should lead to an improved understanding of asthma and to important novel therapies for asthma and allergy. ..
  55. Oral Tolerance Induced by Encapsulated Allergen
    DALE UMETSU; Fiscal Year: 2004
    ..These studies therefore, are likely to lead to better methods and therapies that will induce protective immunity and allergen-specific tolerance, which will potentially cure patients with asthma and allergic diseases. ..
  56. Role of Th Cell Subsets in Allergic Lung Inflammation
    DALE UMETSU; Fiscal Year: 2007
    ..These studies will ascertain the precise role of NK T cells in the development of asthma, and greatly enhance our understanding of pathogenic and protective mechanisms in asthma. ..
  57. Technology and Endothelial Biology of Kidney Injury Molecule-1
    Vishal Vaidya; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  58. Mechanisms by which Influenza A Protects Against Asthma
    DALE UMETSU; Fiscal Year: 2008
    ..We will also learn more about regulatory mechanisms that affect airway inflammation, and how viral infections and the environment affect the development of asthma. ..
  59. PLACENTAL FUNCTION IN PREECLAMPSIA
    Yuping Wang; Fiscal Year: 2009
    ..Results obtained from the proposed work should enhance our knowledge and establish a direct link of placental TC activity and EC dysfunction in PE. ..
  60. Novel Small Molecule Adjuvants to Drug-eluting Stents
    Prakash Narayan; Fiscal Year: 2008
    ..A small molecule therapeutic that reduces restenosis has tremendous clinical benefit. [unreadable] [unreadable] [unreadable]..
  61. Mn transport in the Belgrade rat
    Marianne Wessling Resnick; Fiscal Year: 2003
    ..The Belgrade rat provides the model system to address test our hypothesis. ..
  62. SHARED INSTRUMENTATION GRANT
    Zsolt Szabo; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  63. Endothelin Receptor Imaging of Cancer with PET
    Zsolt Szabo; Fiscal Year: 2007
    ..They have the potential to improve selection of cancer patients for treatment with endothelin antagonists. [unreadable] [unreadable] [unreadable]..
  64. IRON CHELATORS PREDICATED ON DESFERRITHIOCIN
    RAYMOND BERGERON; Fiscal Year: 2004
    ....
  65. Interdisciplinary Training in Genetics and Complex Disease(RMI)
    Marianne Wessling Resnick; Fiscal Year: 2008
    ..abstract_text> ..
  66. Desferrithiocin Analogue Actinide Decorporation Agents
    RAYMOND BERGERON; Fiscal Year: 2008
    ..abstract_text> ..
  67. SFT FUNCTION AND REGULATION IN HEMOCHROMATOSIS
    Marianne Wessling Resnick; Fiscal Year: 2003
    ..abstract_text> ..
  68. PET IMAGING OF THE 5HT TRANSPORTER IN ALCOHOLISM
    Zsolt Szabo; Fiscal Year: 2003
    ..The results of this project will lead to better understanding of the role of serotonin in the biological vulnerability for alcoholism and may lead to improved approaches to prevent and treat alcoholism. ..
  69. Interdisciplinary Training in Genetics and Complex Disease(RMI)
    Marianne Wessling Resnick; Fiscal Year: 2008
    ..abstract_text> ..
  70. Iron transport and its regulation in C. elegans
    Marianne Wessling Resnick; Fiscal Year: 2002
    ..elegans; 3) Use genetic selection to establish transport mutants useful for the elucidation of additional proteins involved in iron import and/or export and the factors that regulate these processes. ..