KDM6A

Summary

Gene Symbol: KDM6A
Description: lysine demethylase 6A
Alias: KABUK2, UTX, bA386N14.2, lysine-specific demethylase 6A, bA386N14.2 (ubiquitously transcribed X chromosome tetratricopeptide repeat protein (UTX)), histone demethylase UTX, lysine (K)-specific demethylase 6A, ubiquitously transcribed tetratricopeptide repeat protein X-linked, ubiquitously-transcribed TPR gene on the X chromosome
Species: human

Top Publications

  1. ncbi UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development
    Karl Agger
    Biotech Research and Innovation Centre BRIC, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen, Denmark
    Nature 449:731-4. 2007
  2. ncbi Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination
    Min Gyu Lee
    Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Science 318:447-50. 2007
  3. ncbi A histone H3 lysine 27 demethylase regulates animal posterior development
    Fei Lan
    Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nature 449:689-94. 2007
  4. pmc Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases
    SunHwa Hong
    Nuclear Receptor Biology Section, Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:18439-44. 2007
  5. pmc Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
    Gijs van Haaften
    Wellcome Trust Sanger Institute, Hinxton, UK
    Nat Genet 41:521-3. 2009
  6. pmc Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes
    Gillian L Dalgliesh
    Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK
    Nature 463:360-3. 2010
  7. pmc Structural basis for histone H3 Lys 27 demethylation by UTX/KDM6A
    Toru Sengoku
    RIKEN Systems and Structural Biology Center, Tsurumi, Yokohama, Japan
    Genes Dev 25:2266-77. 2011
  8. pmc UTX, a histone H3-lysine 27 demethylase, acts as a critical switch to activate the cardiac developmental program
    Seunghee Lee
    Pediatric Neuroscience Research Program, Papé Family Pediatric Research Institute, Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239, USA
    Dev Cell 22:25-37. 2012
  9. doi The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming
    Abed Alfatah Mansour
    The Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    Nature 488:409-13. 2012
  10. doi Retinoic acid dependent histone 3 demethylation of the clustered HOX genes during neural differentiation of human embryonic stem cells
    Maryam Shahhoseini
    Department of Genetics at Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, P O Box 19395 4644, Tehran, Iran
    Biochem Cell Biol 91:116-22. 2013

Research Grants

  1. Epigenetic Reprogramming by the Human Papillomavirus E7 Oncoprotein
    MARGARET ERIN MCLAUGHLIN-DRUBIN; Fiscal Year: 2012
  2. Role of UTX in escape from X inactivation
    JOEL BRADFORD BERLETCH; Fiscal Year: 2010
  3. Min Gyu Lee; Fiscal Year: 2014
  4. Jae W Lee; Fiscal Year: 2016
  5. Lama Tarayrah; Fiscal Year: 2014
  6. Roles of Histone H3K27 demethylases in germ cell epigenetic development
    KARL BRYAN SHPARGEL; Fiscal Year: 2010
  7. Mechanism by which regulators of histone methylation control organismal lifespan
    TRAVIS JUSTIN MAURES; Fiscal Year: 2012
  8. Karl Munger; Fiscal Year: 2016
  9. ACQUISTION OF A CYTOMATION MOFLO CELL SORTER
    Timothy Graubert; Fiscal Year: 2001
  10. GENETIC TARGETING OF HEMATOPOIETIC STEM CELLS
    Timothy Graubert; Fiscal Year: 2002

Scientific Experts

Detail Information

Publications134 found, 100 shown here

  1. ncbi UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development
    Karl Agger
    Biotech Research and Innovation Centre BRIC, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen, Denmark
    Nature 449:731-4. 2007
    ..Here we show that the human JmjC-domain-containing proteins UTX and JMJD3 demethylate tri-methylated Lys 27 on histone H3...
  2. ncbi Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination
    Min Gyu Lee
    Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Science 318:447-50. 2007
    ..Here we show that human UTX, a member of the Jumonji C family of proteins, is a di- and trimethyl H3K27 demethylase...
  3. ncbi A histone H3 lysine 27 demethylase regulates animal posterior development
    Fei Lan
    Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nature 449:689-94. 2007
    ..Here we show that the JmjC-domain-containing related proteins UTX and JMJD3 catalyse demethylation of H3K27me3/2...
  4. pmc Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases
    SunHwa Hong
    Nuclear Receptor Biology Section, Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:18439-44. 2007
    ..Here we show the JmjC domain-containing protein UTX (ubiquitously transcribed tetratricopeptide repeat, X chromosome), as well as the related JMJD3 (jumonji domain ..
  5. pmc Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
    Gijs van Haaften
    Wellcome Trust Sanger Institute, Hinxton, UK
    Nat Genet 41:521-3. 2009
    ..Here, we describe inactivating somatic mutations in the histone lysine demethylase gene UTX, pointing to histone H3 lysine methylation deregulation in multiple tumor types...
  6. pmc Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes
    Gillian L Dalgliesh
    Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK
    Nature 463:360-3. 2010
    ..known as KDM5C), a histone H3 lysine 4 demethylase-as well as mutations in the histone H3 lysine 27 demethylase, UTX (KMD6A), that we recently reported...
  7. pmc Structural basis for histone H3 Lys 27 demethylation by UTX/KDM6A
    Toru Sengoku
    RIKEN Systems and Structural Biology Center, Tsurumi, Yokohama, Japan
    Genes Dev 25:2266-77. 2011
    ..Here we report the crystal structures of the catalytic fragment of UTX/KDM6A, an H3K27me3/2-specific demethylase, in the free and H3 peptide-bound forms...
  8. pmc UTX, a histone H3-lysine 27 demethylase, acts as a critical switch to activate the cardiac developmental program
    Seunghee Lee
    Pediatric Neuroscience Research Program, Papé Family Pediatric Research Institute, Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239, USA
    Dev Cell 22:25-37. 2012
    ..Here we show that UTX, a H3K27 demethylase, acts as a critical switch to promote a cardiac-specific gene program...
  9. doi The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming
    Abed Alfatah Mansour
    The Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    Nature 488:409-13. 2012
    ..Here we show in mice and humans that the histone H3 methylated Lys 27 (H3K27) demethylase Utx (also known as Kdm6a) regulates the efficient induction, rather than maintenance, of pluripotency...
  10. doi Retinoic acid dependent histone 3 demethylation of the clustered HOX genes during neural differentiation of human embryonic stem cells
    Maryam Shahhoseini
    Department of Genetics at Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, P O Box 19395 4644, Tehran, Iran
    Biochem Cell Biol 91:116-22. 2013
    ..decrease in methylation of histone H3K27 parallel to an absolute preferential incorporation of the demethylase UTX rather than JMJD3 in RA-induced neural differentiated cells...
  11. ncbi The UTX gene escapes X inactivation in mice and humans
    A Greenfield
    Centre for Molecular and Cellular Biology and Department of Anatomical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia
    Hum Mol Genet 7:737-42. 1998
    ..Here we report the characterization of a widely transcribed X-linked homologue of Uty , called Utx , which maps to the proximal region of the mouse X chromosome and which detects a human X-linked homologue at Xp11...
  12. pmc Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth
    Irina Issaeva
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Mol Cell Biol 27:1889-903. 2007
    ..shared with other SET1 family complexes and several unique components, such as PTIP and the jumonji family member UTX. Like other complexes formed by SET1 family members, the ALR complex exhibited strong H3K4 methyltransferase ..
  13. doi Mutations of polycomb-associated gene ASXL1 in myelodysplastic syndromes and chronic myelomonocytic leukaemia
    Véronique Gelsi-Boyer
    Centre de Recherche en Cancerologie de Marseille, Département d Oncologie Moléculaire, UMR891 Inserm, Institut Paoli Calmettes, France
    Br J Haematol 145:788-800. 2009
    ..g. ASXL1, ASXL2, UTX, CXXC4, CXXC5, TET2, TET3). To validate some of these candidates we studied the sequence of ASXL1...
  14. doi The potential role of epigenetic therapy in multiple myeloma
    Emma M Smith
    Institute of Cancer Research, Sutton, Surrey, UK
    Br J Haematol 148:702-13. 2010
    ..to the overexpression of a histone methylatransferase (MMSET) and inactivating mutations of a histone demethylase (UTX), suggesting that the regulation of histone methylation is a potential therapeutic target...
  15. doi Genetic heterogeneity and chromatin modifiers in renal clear cell carcinoma
    Peter Staller
    Biotech Research and Innovation Centre, University of Copenhagen, Ole Maaløes Vej 5, DK 2200 Copenhagen N, Denmark
    Future Oncol 6:897-900. 2010
    ..One of these, UTX, has recently been implicated in the control of cell proliferation...
  16. pmc UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development
    Karl B Shpargel
    Department of Genetics, Carolina Center for Genome Sciences, and Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS Genet 8:e1002964. 2012
    UTX (KDM6A) and UTY are homologous X and Y chromosome members of the Histone H3 Lysine 27 (H3K27) demethylase gene family...
  17. pmc Cross-species functional genomic analysis identifies resistance genes of the histone deacetylase inhibitor valproic acid
    Rakel Brendsdal Forthun
    Institute of Medicine, Hematology Section, University of Bergen, Bergen, Norway
    PLoS ONE 7:e48992. 2012
    ..One sensitizer identified as a conserved determinant of therapeutic success of HDACi was UTX (KDM6A), which demonstrates a functional relationship between protein acetylation and lysine-specific methylation...
  18. doi Ezh1 and Ezh2 differentially regulate PSD-95 gene transcription in developing hippocampal neurons
    Berta Henriquez
    Center for Biomedical Research, Universidad Andres Bello, Avenida Republica 239, Santiago, Chile Faculty of Biological Sciences and Faculty of Medicine, Universidad Andres Bello, Avenida Republica 239, Santiago, Chile
    Mol Cell Neurosci 57:130-43. 2013
    ..to the antagonizing effects of the H3S28P and H3K27Ac marks and the activity of the H3K27 demethylases JMJD3 and UTX. In contrast, increased PSD-95 gene transcription is accompanied by the presence of Ezh1 and elongation-engaged RNA ..
  19. pmc Interleukin-4-mediated 15-lipoxygenase-1 trans-activation requires UTX recruitment and H3K27me3 demethylation at the promoter in A549 cells
    Hongya Han
    Department of Medicine, Division of Hematology, Karolinska University Hospital Solna and Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 9:e85085. 2014
    ..we found that the H3K27me2/3-specific demethylase, ubiquitously transcribed tetratricopeptide repeat, X chromosome (UTX), mediates the H3K27me3 demethylation during ALOX15 transcriptional activation...
  20. doi Uterine transplantation in primates: a mini-review of the literature
    I Kisu
    Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo, Japan
    Transplant Proc 46:1212-6. 2014
    ..Uterus transplantation (UTx) is now a possible approach for women with uterine-factor infertility to deliver a child...
  21. doi Uterus transplantation trial: 1-year outcome
    Liza Johannesson
    Department of Obstetrics and Gynecology, Sahlgrenska Academy at University of Gothenburg, Goteborg, Sweden
    Fertil Steril 103:199-204. 2015
    To report the 12-month outcome of seven patients with viable uteri after uterus transplantation (UTx).
  22. pmc Inhibition of H3K27me3-specific histone demethylases JMJD3 and UTX blocks reactivation of herpes simplex virus 1 in trigeminal ganglion neurons
    Harald G P Messer
    Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, Florida, USA
    J Virol 89:3417-20. 2015
    ..Here we demonstrate that GSK-J4, a specific inhibitor of the H3K27me3 histone demethylases UTX and JMJD3, inhibits HSV-1 reactivation from sensory neurons in vitro...
  23. pmc The roles of chromatin-remodelers and epigenetic modifiers in kidney cancer
    Lili Liao
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA
    Cancer Genet 208:206-14. 2015
    ..JARID1C and UTX, two histone H3 demethylases, were also found to harbor mutations in ccRCC, albeit at lower rates...
  24. pmc Genome-wide activities of Polycomb complexes control pervasive transcription
    Hun Goo Lee
    Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA
    Genome Res 25:1170-81. 2015
    ..regions and is governed by opposing roaming activities of PRC2 and complexes containing the H3K27 demethylase UTX. Surprisingly, loss of H3K27me2 results in global transcriptional derepression proportionally greatest in silent or ..
  25. doi Genome-wide association between Six4, MyoD, and the histone demethylase Utx during myogenesis
    Imane Chakroun
    Ottawa Institute of Systems Biology, Ottawa, Ontario, Canada and Department of Biochemistry, Microbiology, and Immunology and Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    FASEB J 29:4738-55. 2015
    ..adult myoblasts, the cooperation between Six4 and MyoD is associated with chromatin repressive mark removal by Utx, a demethylase of histone H3 trimethylated at lysine 27...
  26. doi Loss of BAF (mSWI/SNF) Complexes Causes Global Transcriptional and Chromatin State Changes in Forebrain Development
    Ramanathan Narayanan
    Institute of Neuroanatomy, University Medical Center, Georg August University Goettingen, 37075 Goettingen, Germany
    Cell Rep 13:1842-54. 2015
    ..We demonstrate that BAF complexes interact with H3K27 demethylases (JMJD3 and UTX) and potentiate their activity...
  27. pmc Pleiotropic Functions of H3K27Me3 Demethylases in Immune Cell Differentiation
    Remy Bosselut
    Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA Electronic address
    Trends Immunol 37:102-13. 2016
    ..Whereas H3K27Me3 was thought to be stable and not catalytically reversible, the discovery of the Utx and Jmjd3 demethylases changed this notion, raising new questions on the role of these enzymes in gene expression ..
  28. pmc Epigenetic Dysfunction in Turner Syndrome Immune Cells
    Bradly J Thrasher
    Department of Pediatrics, University of North Carolina, Chapel Hill, NC, USA
    Curr Allergy Asthma Rep 16:36. 2016
    ..Recently, ubiquitously transcribed tetratricopeptide repeat on the X chromosome (UTX), a histone H3 lysine 27 (H3K27) demethylase, has been identified as a downregulated gene in TS immune cells...
  29. ncbi [PRODUCT OF THE BMI1--A KEY COMPONENT OF POLYCOMB--POSITIVELY REGULATES ADIPOCYTE DIFFERENTIATION OF MOUSE MESENCHYMAL STEM CELLS]
    N S Petrov
    Tsitologiia 58:83-90. 2016
    ..associated with an increase in the expression levels of BMI1, the genes of pRb family (RB, p130) and demethylase UTX, but not methyltransferase EZH2, whose products regulate the methylation levels of H3K27...
  30. pmc The Maternal Effect Genes UTX and JMJD3 Play Contrasting Roles in Mus musculus Preimplantation Embryo Development
    Lei Yang
    The Key Laboratory of the National Education Ministry for Mammalian Reproductive Biology and Biotechnology, Inner Mongolia University, Hohhot, People s Republic of China
    Sci Rep 6:26711. 2016
    ..We also determined that H3K27me3-specific demethylases, UTX and JMJD3, were observed at high transcript and protein levels in mouse preimplantation embryos...
  31. ncbi The Roles of Histone Demethylase UTX and JMJD3 (KDM6B) In Cancers: Current Progress and Future Perspectives
    Zhan Gang Xiao
    Rm 521A, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N T, Hong Kong, China
    Curr Med Chem . 2016
    ..Histone H3 lysine 27 trimethylation (H3K27me3) exerts a repressive epigenetic mark on a large number of genes. UTX and JMJD3 are the only two histone demethylases which activate gene expression via demethylating H3K27me3 to ..
  32. pmc Increasing Notch signaling antagonizes PRC2-mediated silencing to promote reprograming of germ cells into neurons
    Stefanie Seelk
    Berlin Institute for Medical Systems Biology, Max Delbruck Center for Molecular Medicine, Berlin, Germany
    elife 5:. 2016
    ..specific genes, silenced by the Polycomb repressive complex 2 (PRC2), and identify the conserved histone demethylase UTX-1 as a crucial GLP-1/Notch target facilitating reprograming...
  33. doi UTX-1 regulates Tat-induced HIV-1 transactivation via changing the methylated status of histone H3
    Hong Sheng Zhang
    College of Life Science and Bioengineering, Beijing University of Technology, Pingleyuan 100, District of Chaoyang, Beijing 100124, China Electronic address
    Int J Biochem Cell Biol 80:51-56. 2016
    ..The removal of histone H3 lysine27 (H3K27) trimethylation mark by UTX-1 is important for the robust induction of many specific genes during Tat-mediated HIV-1 transactvation...
  34. pmc The histone demethylase UTX regulates the lineage-specific epigenetic program of invariant natural killer T cells
    Semir Beyaz
    Division of Hematology Oncology, Boston Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol . 2016
    ..Here we found that the H3K27me3 histone demethylase UTX was an essential cell-intrinsic factor that controlled an iNKT-cell lineage-specific gene-expression ..
  35. pmc The Drosophila ortholog of MLL3 and MLL4, trithorax related, functions as a negative regulator of tissue growth
    Hiroshi Kanda
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA
    Mol Cell Biol 33:1702-10. 2013
    ..The trr mutant phenotype resembles that of Utx, which encodes a H3K27 demethylase, consistent with the observation that Trr and Utx are found in the same protein ..
  36. doi MLL2 and KDM6A mutations in patients with Kabuki syndrome
    Noriko Miyake
    Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Am J Med Genet A 161:2234-43. 2013
    ..Mutations in MLL2 and KDM6A cause Kabuki syndrome...
  37. pmc Molecular pathways: deregulation of histone h3 lysine 27 methylation in cancer-different paths, same destination
    Teresa Ezponda
    Division of Hematology Oncology, Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois
    Clin Cancer Res 20:5001-8. 2014
    ..complex PRC2 and accessory proteins, and deletions and inactivating mutations of the H3K27 demethylase UTX in a wide variety of neoplasms...
  38. pmc MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function
    David W Scoville
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN
    Diabetes 64:3772-83. 2015
    ..We propose that MLL3 and MLL4 are broadly required for controlling MAFA and MAFB transactivation during development and postnatally. ..
  39. pmc JMJD3 as an epigenetic regulator in development and disease
    Jana S Burchfield
    Center for Inflammation and Epigenetics, Houston Methodist Research Institute, Houston, TX 77030, USA
    Int J Biochem Cell Biol 67:148-57. 2015
    ..containing-3 (Jmjd3, KDM6B) and ubiquitously transcribed X-chromosome tetratricopeptide repeat protein (UTX, KDM6A) have been identified as H3K27 demethylases that catalyze the demethylation of H3K27me2/3...
  40. pmc An essential role for UTX in resolution and activation of bivalent promoters
    Shilpa s Dhar
    Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Nucleic Acids Res 44:3659-74. 2016
    ..Here, we show that the H3K27 demethylase UTX (also called KDM6A) is required for the resolution and activation of numerous retinoic acid (RA)-inducible bivalent genes during the ..
  41. doi Psychological Issues Associated With Absolute Uterine Factor Infertility and Attitudes of Patients Toward Uterine Transplantation
    Srdjan Saso
    Division of Surgery and Cancer, Institute of Reproductive and Developmental Biology, Imperial College London, London, United Kingdom
    Prog Transplant 26:28-39. 2016
    Uterine transplantation (UTx).
  42. ncbi Increased expression of the histone H3 lysine 4 methyltransferase MLL4 and the histone H3 lysine 27 demethylase UTX prolonging the overall survival of patients with glioblastoma and a methylated MGMT promoter
    Jinho Kim
    Department of Neurosurgery, Division of NeuroOncology, and
    J Neurosurg . 2016
    ..leukemia 4 [MLL4]) and H3K27 demethylase (ubiquitously transcribed tetratricopeptide repeat gene on X chromosome [UTX]) in progression-free survival (PFS) and overall survival (OS) of patients with glioblastoma (GBM) who were treated ..
  43. pmc MLL3/MLL4/COMPASS Family on Epigenetic Regulation of Enhancer Function and Cancer
    Christie C Sze
    Department of Biochemistry and Molecular Genetics and Robert H Lurie NCI Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611
    Cold Spring Harb Perspect Med 6:. 2016
    ..members of the COMPASS family of histone H3 lysine 4 (H3K4) methyltransferases, and their complex-specific subunit UTX, a histone H3 lysine 27 (H3K27) demethylase...
  44. doi Histone demethylase UTX counteracts glucocorticoid deregulation of osteogenesis by modulating histone-dependent and -independent pathways
    Feng Sheng Wang
    Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, 123, Ta Pei Road, Niao Sung District, Kaohsiung, 83303, Taiwan
    J Mol Med (Berl) . 2017
    ..This study was undertaken to delineate the actions of histone lysine demethylase 6a (UTX) with regard to the glucocorticoid impediment of osteogenic differentiation...
  45. pmc Genome-wide profiling reveals stimulus-specific functions of p53 during differentiation and DNA damage of human embryonic stem cells
    Kadir C Akdemir
    Program in Genes and Development, UT Graduate School in Biomedical Sciences at Houston, Center for Stem Cell and Development Biology, Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA, Division of Biomedical Informatics, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA and Dan L Duncan Cancer Center, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Nucleic Acids Res 42:205-23. 2014
    ..Activation of these genes occurs with recruitment of p53 and H3K27me3-specific demethylases, UTX and JMJD3, to chromatin...
  46. pmc Fast and non-invasive PCR sexing of primates: apes, Old World monkeys, New World monkeys and Strepsirrhines
    Palle Villesen
    Bioinformatics Research Center BiRC, University of Aarhus, H, Guldbergsgade 10, Building 1090, DK 8000 Aarhus C, Denmark
    BMC Ecol 6:8. 2006
    ..Hence, it is highly desirable to develop markers that simultaneously detect Y- and X-chromosome specific sequences and also work across many species...
  47. pmc Sex-specific differences in expression of histone demethylases Utx and Uty in mouse brain and neurons
    Jun Xu
    Department of Pathology and Medicine, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 28:4521-7. 2008
    ..b>Utx (ubiquitously transcribed tetratricopeptide repeat gene on X chromosome) is an escapee gene that encodes a ..
  48. doi Identification of the chromatin regions coated by non-coding Xist RNA
    K Murakami
    Department of Biomedical Science, Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Yonago, Japan
    Cytogenet Genome Res 125:19-25. 2009
    ..In mouse cells, Xist RNA was detected on the Uba1 gene, but not on Jarid1c and Utx genes, which escape from XCI...
  49. doi Histone demethylase UTX-1 regulates C. elegans life span by targeting the insulin/IGF-1 signaling pathway
    Chunyu Jin
    Chinese Academy of Sciences Key Laboratory of Computational Biology, Chinese Academy of Sciences Max Planck Partner Institute for Computational Biology, China
    Cell Metab 14:161-72. 2011
    ..and loss of H3K27me3 on IIS components are due, at least in part, to increased activity of the H3K27 demethylase UTX-1 during aging. RNAi of the utx-1 gene extended the mean life span of C...
  50. pmc KSHV PAN RNA associates with demethylases UTX and JMJD3 to activate lytic replication through a physical interaction with the virus genome
    Cyprian C Rossetto
    The Department of Microbiology and Immunology, University of Nevada, Reno School of Medicine, Reno, Nevada, United States of America
    PLoS Pathog 8:e1002680. 2012
    ..RNA chromatin immunoprecipitation assays show that PAN RNA interacts with demethylases JMJD3 and UTX, and the histone methyltransferase MLL2...
  51. pmc Copy number analysis of 413 isolated talipes equinovarus patients suggests role for transcriptional regulators of early limb development
    David M Alvarado
    Department of Orthopaedic Surgery, Washington University School of Medicine, St Louis, MO, USA
    Eur J Hum Genet 21:373-80. 2013
    ..and contain the developmentally expressed transcription factors and transcriptional regulators PITX1, TBX4, HOXC13, UTX, CHD (chromodomain protein)1, and RIPPLY2...
  52. pmc Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma
    Adrian M Dubuc
    Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada
    Acta Neuropathol 125:373-84. 2013
    ..Notably, we also report mutations affecting the MLL2-binding partner KDM6A, in 4 % (7/175) of tumors...
  53. pmc Histone lysine demethylases in breast cancer
    Elisa Paolicchi
    Transgenic Oncogenesis and Genomics Section, Laboratory of Cancer Biology and Genetics, National Cancer Institute NIH, Bethesda, MD 20892, USA
    Crit Rev Oncol Hematol 86:97-103. 2013
    ..005 and response to docetaxel p=0.005); conversely, KDM6A is overexpressed in BC patients with an unfavorable prognosis (mortality at 1 year, p=8.65E-7)...
  54. doi Boron tracedrug design for neutron dynamic therapeutics for LDL
    Hitoshi Hori
    Department of Life System, Institute of Technology and Science, Graduate School, The University of Tokushima, Minamijosanjimacho 2, Tokushima, 770 8506, Japan
    Adv Exp Med Biol 789:385-9. 2013
    ..Thus, we examined, among our developed boron tracedrugs, a boron-containing curcuminoid derivative UTX-51, to destroy freshly isolated human LDL dynamically under irradiated thermal neutron to obtain a decreased ..
  55. ncbi Administration of oral charcoal adsorbent (AST-120) suppresses low-turnover bone progression in uraemic rats
    Yoshiko Iwasaki
    Department of Health Sciences, Oiya University of Nursing and Health Sciences, Oita 870 1201, Japan
    Nephrol Dial Transplant 21:2768-74. 2006
    ..that bone formation decreased depending on the degree of renal dysfunction, and hypothesized that uraemic toxins (UTx) are associated with the development of low-turnover bone development, complicating renal failure...
  56. ncbi Mammalian male mutation bias: impacts of generation time and regional variation in substitution rates
    M Paula Goetting-Minesky
    Department of Biology, Center for Comparative Genomics and Bioinformatics, 518A Mueller Lab, Penn State University, University Park, PA 16803, USA
    J Mol Evol 63:537-44. 2006
    ..Here we sequenced and analyzed five introns of three genes (DBX/DBY, UTX/UTY, and ZFX/ZFY) homologous between X and Y chromosomes in several species of perissodactyls (horses and rhinos) ..
  57. doi The ethics of uterus transplantation
    Ruby Catsanos
    Department of Philosophy, Macquarie University, Sydney, NSW, Australia
    Bioethics 27:65-73. 2013
    Human uterus transplantation (UTx) is currently under investigation as a treatment for uterine infertility...
  58. doi Does the incidence of unexpected malignancy in 'benign' rectal neoplasms undergoing trans-anal endoscopic microsurgery vary according to lesion morphology?
    I Dash
    Cheltenham General Hospital GHNHSFT, Cheltenham, UK
    Colorectal Dis 15:183-6. 2013
    ..This study examines the relationship between lesion morphology and accurate benign preoperative classification of rectal lesions undergoing TEMS...
  59. doi Absence of deletion and duplication of MLL2 and KDM6A genes in a large cohort of patients with Kabuki syndrome
    Manuela Priolo
    Unita Operativa di Genetica Medica, Azienda Ospedaliera Bianchi Melacrino Morelli, Reggio Calabria, Italy
    Mol Genet Metab 107:627-9. 2012
    ..syndrome is a rare, multiple congenital anomaly/mental retardation syndrome caused by MLL2 point mutations and KDM6A microdeletions...
  60. pmc Histone H3K27me3 demethylases KDM6A and KDM6B modulate definitive endoderm differentiation from human ESCs by regulating WNT signaling pathway
    Wei Jiang
    Howard Hughes Medical Institute, Chevy Chase, Maryland 20815 6789, USA
    Cell Res 23:122-30. 2013
    ..Here, we show that the H3K27me3 demethylases KDM6A and KDM6B play an important role in endoderm differentiation from human ESCs...
  61. pmc Expression and significance of histone H3K27 demethylases in renal cell carcinoma
    Yongqing Shen
    Laboratory of Iron Metabolism and Molecular Biology, College of Life Science, Hebei Normal University, Shijiazhuang 050016, China
    BMC Cancer 12:470. 2012
    The histone H3K27 demethylases UTX and JMJD3 are important regulatory factors that modulate gene expression by altering the physical state of chromatin...
  62. ncbi Targeting of NF-kappaB signaling pathway, other signaling pathways and epigenetics in therapy of multiple myeloma
    Ota Fuchs
    Institute of Hematology and Blood Transfusion, Prague 2, Czech Republic
    Cardiovasc Hematol Disord Drug Targets 13:16-34. 2013
    ..of MM genomes revealed also mutations in genes for histone methyltransferases (HMTases), histone demethylase (UTX) and serine/threonine protein kinase BRAF...
  63. pmc Aberrant promoter hypermethylation of PBRM1, BAP1, SETD2, KDM6A and other chromatin-modifying genes is absent or rare in clear cell RCC
    Ilsiya Ibragimova
    Cancer Epigenetics Program and Kidney Keystone Program, Fox Chase Cancer Center, Philadelphia, PA, USA
    Epigenetics 8:486-93. 2013
    ..renal cell carcinoma (ccRCC) have identified inactivating point mutations in the chromatin-modifying genes PBRM1, KDM6A/UTX, KDM5C/JARID1C, SETD2, MLL2 and BAP1...
  64. pmc Deletion of KDM6A, a histone demethylase interacting with MLL2, in three patients with Kabuki syndrome
    Damien Lederer
    Centre de Genetique Humaine, Institut de Pathologie et Genetique, Charleroi, Belgium
    Am J Hum Genet 90:119-24. 2012
    ..Here, we describe three KS individuals with de novo partial or complete deletions of an X chromosome gene, KDM6A, that encodes a histone demethylase that interacts with MLL2...
  65. doi Uterus transplantation in a non-human primate: long-term follow-up after autologous transplantation
    L Johannesson
    Department of Obstetrics and Gynecology, University of Gothenburg, Gothenburg, Sweden
    Hum Reprod 27:1640-8. 2012
    Uterus transplantation (UTx) may provide the first available treatment for women affected by uterine infertility...
  66. pmc Histone demethylase UTX and chromatin remodeler BRM bind directly to CBP and modulate acetylation of histone H3 lysine 27
    Feng Tie
    Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio, USA
    Mol Cell Biol 32:2323-34. 2012
    ..we show that H3K27ac levels also depend on other TrxG proteins, including the histone H3K27-specific demethylase UTX and the chromatin-remodeling ATPase Brahma (BRM)...
  67. doi Effects of immunosuppression by cyclosporine A on allogenic uterine transplant in the rat
    Klaus Groth
    Department of Obstetrics and Gynecology, Sahlgrenska Academy at University of Gothenburg, S 413 45 Gothenburg, Sweden
    Eur J Obstet Gynecol Reprod Biol 163:97-103. 2012
    Research on uterine transplantation (UTx) is conducted in preparation for its introduction in the human as a treatment for absolute uterine factor infertility...
  68. doi Comparative expression analysis of the H3K27 demethylases, JMJD3 and UTX, with the H3K27 methylase, EZH2, in Xenopus
    Akane Kawaguchi
    Graduate School of Biological Sciences, Nara Institute of Science and Technology NAIST, Ikoma, Nara, Japan
    Int J Dev Biol 56:295-300. 2012
    ..activation of developmental genes; however, the extent of embryonic expression of its demethylases, JMJD3 and UTX, has remained unclear...
  69. pmc Histone recognition and nuclear receptor co-activator functions of Drosophila cara mitad, a homolog of the N-terminal portion of mammalian MLL2 and MLL3
    Chhavi Chauhan
    Oncology Institute, Stritch School of Medicine, Loyola University of Chicago, Maywood, IL 60153, USA
    Development 139:1997-2008. 2012
    ..requires chromatin binding by CMI, methylation of H3K4 by TRR and demethylation of H3K27 by the demethylase UTX. The evolutionary split of MLL2 into two distinct genes in Drosophila provides important insight into distinct ..
  70. pmc The C. elegans H3K27 demethylase UTX-1 is essential for normal development, independent of its enzymatic activity
    Julien Vandamme
    Biotech Research and Innovation Centre BRIC, University of Copenhagen, Copenhagen, Denmark
    PLoS Genet 8:e1002647. 2012
    ..Here we report on the biological functions of UTX-1, the Caenorhabditis elegans homologue of mammalian UTX, a histone demethylase specific for H3K27me2/3...
  71. pmc The mutational landscape of lethal castration-resistant prostate cancer
    Catherine S Grasso
    Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Nature 487:239-43. 2012
    ..that physically interact with the AR, such as the ERG gene fusion product, FOXA1, MLL2, UTX (also known as KDM6A) and ASXL1 were found to be mutated in CRPC...
  72. pmc X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific manner
    G Grant Welstead
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 109:13004-9. 2012
    ..It has been suggested that the recently discovered class of histone demethylases (UTX and JMJD3) that specifically target the repressive H3K27me3 modification play an important role in the activation ..
  73. pmc Jumonji domain-containing protein 3 regulates histone 3 lysine 27 methylation during bovine preimplantation development
    Sebastian Canovas
    Laboratorio Andaluz de Reprogramación Celular, Consejeria de Salud, Junta de Andalucia, 41092 Seville, Spain
    Proc Natl Acad Sci U S A 109:2400-5. 2012
    ..Jumonji domain-containing protein 3 (JMJD3), but not ubiquitously transcribed tetratricopeptide repeat X (UTX), present high transcript levels in oocytes...
  74. doi Uterine transplantation research: laboratory protocols for clinical application
    C Diaz-Garcia
    Department of Obstetrics and Gynecology, Sahlgrenska Academy, University of Gothenburg, Gothenburg SE 41345, Sweden
    Mol Hum Reprod 18:68-78. 2012
    ..clinical organ transplantation today, as well as the major findings of recent experimental uterus transplantation (UTx) research regarding organ donation/retrieval, ischemic preservation, surgical techniques for anastomosis, ..
  75. pmc Chronic myelomonocytic leukemia and atypical chronic myeloid leukemia: novel pathogenetic lesions
    Hideki Muramatsu
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Semin Oncol 39:67-73. 2012
    ..proliferation signaling (CBL, RAS, RUNX1, JAK2 (V617F)) and with modification of epigenetic status (TET2, ASXL1, UTX, EZH2) have been found...
  76. pmc Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms
    D Grbavec
    Center for Neuronal Survival, Montreal Neurological Institute, 3801 rue University, Montreal, Quebec, H3A 2B4 Canada
    Biochem J 337:13-7. 1999
    ..These findings suggest that mammalian TLE and UTY/X proteins may mediate repression mechanisms similar to those performed by TUP1-SSN6 in yeast...
  77. ncbi Molecular and genetic analysis of the Tribolium Ultrabithorax ortholog, Ultrathorax
    R L Bennett
    Zoology Department, Brigham Young University, Provo, UT 84602, USA
    Dev Genes Evol 209:608-19. 1999
    ..Phenotypic analysis of mutant variants of the Ultrathorax (Utx) gene, and its location within the beetle HOM-C, strongly supports Utx being the Tribolium ortholog of Ubx...
  78. ncbi Deletion and expression analysis of AZFa genes on the human Y chromosome revealed a major role for DBY in male infertility
    C Foresta
    University of Padova, Department of Medical and Surgical Sciences, Clinica Medica 3, 35128 Padova, Italy
    Hum Mol Genet 9:1161-9. 2000
    ..This hypothesis is further supported by the high similarity of DBY to other DEAD box proteins belonging to the PL10 subclass...
  79. ncbi UTY gene codes for an HLA-B60-restricted human male-specific minor histocompatibility antigen involved in stem cell graft rejection: characterization of the critical polymorphic amino acid residues for T-cell recognition
    M H Vogt
    Departments of Hematology and Immunohematology and Bloodbank, Leiden University Medical Center, Leiden, The Netherlands
    Blood 96:3126-32. 2000
    ..Although the epitope differed by 3 amino acids from its X-homologue, UTX, only 2 polymorphisms were essential for recognition by the CTL clone HLA-B60 HY...
  80. ncbi Sex differences in sex chromosome gene expression in mouse brain
    Jun Xu
    Department of Physiological Science and Laboratory of Neuroendocrinology of the Brain Research Institute, University of California, Los Angeles, CA 90095 1606, USA
    Hum Mol Genet 11:1409-19. 2002
    ..Six X-linked homologues (Usp9x, Ube1x, Smcx, Eif2s3x, Utx and Dbx) were also expressed in brain, and in adulthood all of these transcripts were expressed at significantly ..
  81. ncbi Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches
    Robert J Agate
    Department of Physiological Science, University of California, Los Angeles, USA
    Mol Biol Evol 21:384-96. 2004
    ..These differences between CHD1Z and CHD1W suggest that the two proteins may have diverged in their function...
  82. ncbi Impact of chemoradiotherapy-induced anemia on survival in uniformly staged patients with locally advanced squamous cell carcinoma of the esophagus
    R D Hofheinz
    Okologisches Zentrum, III, Medizinische Klinik, Fakultät für Klinische Medizin Mannheim der Universität Heidelberg, Germany
    Onkologie 27:462-6. 2004
    ....
  83. ncbi Positive and negative selection on mammalian Y chromosomes
    Dave T Gerrard
    School of Biosciences, The University of Birmingham, Edgbaston, Birmingham, United Kingdom
    Mol Biol Evol 22:1423-32. 2005
    ..Taking positive selection into account, we demonstrate that purifying selection is less efficient in mammalian Y-linked genes compared to their X-linked homologues, suggesting that these genes continue to degenerate...
  84. ncbi Preliminary findings on the classical singer's use of the pectoralis major muscle
    Viggo Pettersen
    Department of Music and Dance, University of Stavanger, Stavanger, Norway
    Folia Phoniatr Logop 58:427-39. 2006
    ..The activity in the pectoralis major (PC) muscle and the phasing of PC activity to sternocleidomastoideus (STM) activity and upper thorax (UTX) movement were investigated.
  85. ncbi Indoxyl sulfate induces skeletal resistance to parathyroid hormone in cultured osteoblastic cells
    T Nii-Kono
    Division of Nephrology and Dialysis Center, Department of Internal Medicine, Kobe University School of Medicine, Kobe, Japan
    Kidney Int 71:738-43. 2007
    ..In the present study, we focused on the accumulation of uremic toxins (UTx) in blood, and examined whether indoxyl sulfate (IS), a UTx, is associated with PTH resistance...
  86. pmc PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex
    Young Wook Cho
    Nuclear Receptor Biology Section, Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Biol Chem 282:20395-406. 2007
    ..SET domain-containing HMTs MLL3 and MLL4, and substoichiometric amount of JmjC domain-containing putative histone demethylase UTX. PTIP complex carries robust HMT activity and specifically methylates lysine 4 (K4) on histone H3...
  87. ncbi H3K27 demethylases, at long last
    Tomek Swigut
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 131:29-32. 2007
    ..2007; De Santa et al., 2007; Lan et al., 2007; Lee et al., 2007) identify the JmjC-domain proteins UTX and JMJD3 as H3K27-specific demethylases that remove this methyl mark, enabling the activation of genes involved in ..
  88. pmc The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex
    Sanjeevkumar R Patel
    Department of Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Dev Cell 13:580-92. 2007
    ..Embryonic lethal ptip-null mutants and conditional mutants both show reduced levels of methylated H3K4. Thus, PTIP bridges DNA-binding developmental regulators to histone methyltransferase-dependent epigenetic regulation...
  89. pmc Drosophila UTX is a histone H3 Lys27 demethylase that colocalizes with the elongating form of RNA polymerase II
    Edwin R Smith
    Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA
    Mol Cell Biol 28:1041-6. 2008
    ..Our data indicate that dUTX is intimately associated with actively transcribed genes and may provide a paradigm for how H3K27 demethylation is required for the activation of preinitiated Pol II on transcriptionally poised genes...
  90. doi Consequences from emotional stimulus on breathing for singing
    Viggo Pettersen
    Department of Music and Dance, University of Stavanger, Stavanger, Norway
    J Voice 23:295-303. 2009
    ..RC], lateral abdomen [OBL], and lower lateral abdomen [LOBL]) muscle activity and trunk wall (upper thorax [UTX], lower thorax [LTX], and abdomen [ABD]) movement...
  91. doi Influence of new Eurotransplant heart allocation policy on outcome of heart transplant candidates in Germany
    Takeshi Komoda
    Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Berlin, Germany
    J Heart Lung Transplant 27:1108-14. 2008
    ..The Eurotransplant community adopted an urgency-based heart allocation algorithm in August 2000. The effect of the new allocation policy on critically ill patients with end-stage heart failure was studied...
  92. pmc A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation
    Patrick S Tarpey
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK
    Nat Genet 41:535-43. 2009
    ..The study has, however, also highlighted issues confronting whole-genome sequencing screens, including the observation that loss of function of 1% or more of X-chromosome genes is compatible with apparently normal existence...
  93. pmc Epigenetic reprogramming during wound healing: loss of polycomb-mediated silencing may enable upregulation of repair genes
    Tanya Shaw
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol, UK
    EMBO Rep 10:881-6. 2009
    ..Suz12 are significantly downregulated during murine skin repair, whereas the newly described demethylases Jmjd3 and Utx are markedly upregulated...
  94. doi Design of a bioreductively-activated fluorescent pH probe for tumor hypoxia imaging
    Eiji Nakata
    Department of Life System, Institute of Technology and Science, Graduate School, The University of Tokushima, Minamijosanjimacho 2, Tokushima 770 8506, Japan
    Bioorg Med Chem 17:6952-8. 2009
    We have designed and evaluated UTX-12 as a novel fluorescent pH probe for tumor hypoxia imaging...
  95. pmc Dual role for the methyltransferase G9a in the maintenance of beta-globin gene transcription in adult erythroid cells
    Chandra Prakash Chaturvedi
    The Sprott Center for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON Canada
    Proc Natl Acad Sci U S A 106:18303-8. 2009
    ..Interestingly, the demethylase UTX is recruited to the beta(maj) (but not the E(y)) promoter where it antagonizes G9a-dependent H3K27 dimethylation...
  96. doi Experimental uterus transplantation
    Mats Brannstrom
    Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, Sahlgrenska Academy, University of Gothenburg, Goteborg, Sweden
    Hum Reprod Update 16:329-45. 2010
    Uterus transplantation (UTx) is developed in animal models as a future method to treat uterine factor infertility.
  97. pmc Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
    Ryan D Morin
    Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada
    Nat Genet 42:181-5. 2010
    ..After the recent discovery of mutations in KDM6A (UTX), which encodes the histone H3K27me3 demethylase UTX, in several cancer types, EZH2 is the second histone ..
  98. pmc The histone demethylase UTX enables RB-dependent cell fate control
    Jordon K Wang
    Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 24:327-32. 2010
    Trimethylation of histone H3 on Lys 27 (H3K27me3) is key for cell fate regulation. The H3K27me3 demethylase UTX functions in development and tumor suppression with undefined mechanisms...
  99. doi Design of novel hypoxia-targeting IDO hybrid inhibitors conjugated with an unsubstituted L-TRP as an IDO affinity moiety
    Hitomi Nakashima
    Department of Life System, Institute of Technology and Science, Graduate School, The University of Tokushima, Tokushima 770 8506, Japan
    Adv Exp Med Biol 662:415-21. 2010
    ..an unsubstituted L-Trp as an IDO affinity moiety without inhibitor 1MT, such as L-Trp-TPZ hybrids 1 (TX-2274), 2 (UTX-3), 3 (UTX-4), and 4 (UTX-2)...
  100. pmc The H3K27me3 demethylase dUTX is a suppressor of Notch- and Rb-dependent tumors in Drosophila
    Hans Martin Herz
    M D Anderson Cancer Center, Department of Biochemistry and Molecular Biology, Graduate Program in Genes and Development, 1515 Holcombe Boulevard, Unit 1000, Houston, TX 77030, USA
    Mol Cell Biol 30:2485-97. 2010
    ..27 of histone H3 (H3K27me3) is an epigenetic mark for gene silencing and can be demethylated by the JmjC domain of UTX. Excessive H3K27me3 levels can cause tumorigenesis, but little is known about the mechanisms leading to those ..

Research Grants12

  1. Epigenetic Reprogramming by the Human Papillomavirus E7 Oncoprotein
    MARGARET ERIN MCLAUGHLIN-DRUBIN; Fiscal Year: 2012
    ..that HPV16 E7 induces the enzymes that remove this repressive histone modification, the histone demethylases UTX and JMJD3...
  2. Role of UTX in escape from X inactivation
    JOEL BRADFORD BERLETCH; Fiscal Year: 2010
    ..We proposethat removal of this repressive histone modification by the histone de-methylases UTX and JMJD3 is an essential part of escape from X inactivation. We will pursue the following three aims: Aim1...
  3. Min Gyu Lee; Fiscal Year: 2014
    ..Recently, we identified the H3K27 demethylase KDM6A (also called UTX), a long-sought histone methylation modifier that up-regulates gene expression by demethylating ..
  4. Jae W Lee; Fiscal Year: 2016
    ..Later, ASCOM has also been found to contain the H3-lysine 27-demethylase (H3K27DM) UTX. Trimethylated H3K4 and trimethylated H3K27 mark transcriptionally active and inactive chromatin, respectively...
  5. Lama Tarayrah; Fiscal Year: 2014
    ..Moreover, mammalian UTX has been recently shown to associate with the mammalian homolog of Trx, H3K4me3 histone methyltransferase MLL2 ..
  6. Roles of Histone H3K27 demethylases in germ cell epigenetic development
    KARL BRYAN SHPARGEL; Fiscal Year: 2010
    ..I hypothesize that Utx and JmjdS H3K27 demethylases are required in the early mammalian embryo and will prove essential for reprogramming ..
  7. Mechanism by which regulators of histone methylation control organismal lifespan
    TRAVIS JUSTIN MAURES; Fiscal Year: 2012
    ..Furthermore, we found that the knock-down of the H3K27me3 demethylase UTX- 1 prolonged worm lifespan...
  8. Karl Munger; Fiscal Year: 2016
    ..to determine the mechanism by which HPV16 E7 expression causes increased expression of the two enzymes, JMJD3 and UTX, which remove the repressive trimethyl mark on lysine 27 of histone H3...
  9. ACQUISTION OF A CYTOMATION MOFLO CELL SORTER
    Timothy Graubert; Fiscal Year: 2001
    ..An advisory committee will oversee management of the cell sorter and ensure its long-term stability as a resource for the medical school...
  10. GENETIC TARGETING OF HEMATOPOIETIC STEM CELLS
    Timothy Graubert; Fiscal Year: 2002
    ..The long-term goal of this investigator is to study the molecular bases of hematopoiesis and leukemogenesis as an active member of a clinical Hematology/Bone Marrow Transplant Division. ..
  11. Acquistion of an inFlux GMP cell sorter.
    Timothy Graubert; Fiscal Year: 2005
    ..This instrument will provide added value for many funded projects at Washington University that collectively accounted for over $328M in total awards from the NIH in 2002, placing it third among medical centers in the United States. ..
  12. Role of HPV16 E7/E2F6 interaction in viral oncogenesis
    Margaret McLaughlin Drubin; Fiscal Year: 2006
    ..These studies will further the understanding of how viral proteins interact with cellular factors to induce cancer. [unreadable] [unreadable] [unreadable] [unreadable]..