KDM5B

Summary

Gene Symbol: KDM5B
Description: lysine demethylase 5B
Alias: CT31, JARID1B, PLU-1, PLU1, PPP1R98, PUT1, RBBP2H1A, RBP2-H1, lysine-specific demethylase 5B, cancer/testis antigen 31, histone demethylase JARID1B, jumonji, AT rich interactive domain 1B, jumonji/ARID domain-containing protein 1B, lysine (K)-specific demethylase 5B, protein phosphatase 1, regulatory subunit 98, retinoblastoma-binding protein 2 homolog 1, retinoblastoma-binding protein 2, homolog 1A
Species: human

Top Publications

  1. pmc FOXP3 orchestrates H4K16 acetylation and H3K4 trimethylation for activation of multiple genes by recruiting MOF and causing displacement of PLU-1
    Hiroto Katoh
    Division of Immunotherapy, Department of Surgery, University of Michigan School of Medicine and Cancer Center, Ann Arbor, MI 48109, USA
    Mol Cell 44:770-84. 2011
  2. ncbi A novel gene (PLU-1) containing highly conserved putative DNA/chromatin binding motifs is specifically up-regulated in breast cancer
    P J Lu
    Laboratory of Epithelial Cell Biology, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    J Biol Chem 274:15633-45. 1999
  3. ncbi Gene targeting of Desrt, a novel ARID class DNA-binding protein, causes growth retardation and abnormal development of reproductive organs
    M H Lahoud
    Centre for Functional Genomics and Human Disease, Monash Institute of Reproduction and Development, Monash University, Melbourne, Victoria, Australia
    Genome Res 11:1327-34. 2001
  4. ncbi Human PLU-1 Has transcriptional repression properties and interacts with the developmental transcription factors BF-1 and PAX9
    Keith Tan
    Centre for Structural Biology, Department of Biological Sciences, Imperial College London, Armstrong Road, London SW7 2AZ
    J Biol Chem 278:20507-13. 2003
  5. ncbi PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation
    Kenichi Yamane
    Howard Hughes Medical Institute, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
    Mol Cell 25:801-12. 2007
  6. pmc Functional analysis of the transcription repressor PLU-1/JARID1B
    Angelo G Scibetta
    Breast Cancer Biology Group, King s College London School of Medicine, 3rd Floor, Thomas Guy House, Guy s Hospital, London SE1 9RT, United Kingdom
    Mol Cell Biol 27:7220-35. 2007
  7. pmc Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway
    Shinya Hayami
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, 108 8639, Japan
    Mol Cancer 9:59. 2010
  8. pmc A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth
    Alexander Roesch
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Cell 141:583-94. 2010
  9. pmc PARP-1 regulates chromatin structure and transcription through a KDM5B-dependent pathway
    Raga Krishnakumar
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Mol Cell 39:736-49. 2010
  10. doi PLU-1/JARID1B/KDM5B is required for embryonic survival and contributes to cell proliferation in the mammary gland and in ER+ breast cancer cells
    Steven Catchpole
    Breast Cancer Biology, King s College London, Guy s Hospital, London SE1 9RT, UK
    Int J Oncol 38:1267-77. 2011

Research Grants

  1. Amato J Giaccia; Fiscal Year: 2014
  2. WILLIAM L KRAUS; Fiscal Year: 2016
  3. MEENHARD F HERLYN; Fiscal Year: 2015
  4. CELL CYCLE CHECKPOINT CONTROL IN RESPONSE TO DNA DAMAGE
    Nancy C Walworth; Fiscal Year: 2011
  5. MEENHARD F HERLYN; Fiscal Year: 2015
  6. Using Synthetic Lethality to Select Cancer Drug Targets
    William Kaelin; Fiscal Year: 2005
  7. Real-Time Imaging of Hypoxia based on VHL Activity
    William Kaelin; Fiscal Year: 2006
  8. 2006 Cancer Model Mechanisms
    William Kaelin; Fiscal Year: 2006
  9. A Luciferase Fusion Protein Library to Identify & Monitor Ubiquitylation Targets
    William Kaelin; Fiscal Year: 2008
  10. HYPOXIA AND GENE REPRESSION
    Amato Giaccia; Fiscal Year: 2009

Scientific Experts

Detail Information

Publications148 found, 100 shown here

  1. pmc FOXP3 orchestrates H4K16 acetylation and H3K4 trimethylation for activation of multiple genes by recruiting MOF and causing displacement of PLU-1
    Hiroto Katoh
    Division of Immunotherapy, Department of Surgery, University of Michigan School of Medicine and Cancer Center, Ann Arbor, MI 48109, USA
    Mol Cell 44:770-84. 2011
    ....
  2. ncbi A novel gene (PLU-1) containing highly conserved putative DNA/chromatin binding motifs is specifically up-regulated in breast cancer
    P J Lu
    Laboratory of Epithelial Cell Biology, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    J Biol Chem 274:15633-45. 1999
    ..The presence of the dri motif and PHD/LAP fingers together with the clear nuclear localization and consistent expression in breast cancers, suggest a role for PLU-1 in regulating gene expression in breast cancers...
  3. ncbi Gene targeting of Desrt, a novel ARID class DNA-binding protein, causes growth retardation and abnormal development of reproductive organs
    M H Lahoud
    Centre for Functional Genomics and Human Disease, Monash Institute of Reproduction and Development, Monash University, Melbourne, Victoria, Australia
    Genome Res 11:1327-34. 2001
    ..These data show that this novel DNA-binding protein, Desrt, has a nonredundant function during growth and in the development of the reproductive system...
  4. ncbi Human PLU-1 Has transcriptional repression properties and interacts with the developmental transcription factors BF-1 and PAX9
    Keith Tan
    Centre for Structural Biology, Department of Biological Sciences, Imperial College London, Armstrong Road, London SW7 2AZ
    J Biol Chem 278:20507-13. 2003
    ..Because both BF-1 and PAX proteins interact with members of the groucho co-repressor family, it is plausible that PLU-1 has a role in groucho-mediated transcriptional repression...
  5. ncbi PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation
    Kenichi Yamane
    Howard Hughes Medical Institute, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
    Mol Cell 25:801-12. 2007
    ..Furthermore, we reveal that PLU-1-mediated H3K4 demethylase activity plays an important role in the proliferative capacity of breast cancer cells through repression of tumor suppressor genes, including BRCA1...
  6. pmc Functional analysis of the transcription repressor PLU-1/JARID1B
    Angelo G Scibetta
    Breast Cancer Biology Group, King s College London School of Medicine, 3rd Floor, Thomas Guy House, Guy s Hospital, London SE1 9RT, United Kingdom
    Mol Cell Biol 27:7220-35. 2007
    The PLU-1/JARID1B nuclear protein, which is upregulated in breast cancers, belongs to the ARID family of DNA binding proteins and has strong transcriptional repression activity...
  7. pmc Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway
    Shinya Hayami
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, 108 8639, Japan
    Mol Cancer 9:59. 2010
    ..We investigated the role of KDM5B, a JmjC histone demethylase, in human carcinogenesis...
  8. pmc A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth
    Alexander Roesch
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Cell 141:583-94. 2010
    ..Using the H3K4 demethylase JARID1B (KDM5B/PLU-1/RBP2-H1) as a biomarker, we have characterized a small subpopulation of slow-cycling melanoma cells ..
  9. pmc PARP-1 regulates chromatin structure and transcription through a KDM5B-dependent pathway
    Raga Krishnakumar
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Mol Cell 39:736-49. 2010
    ..preventing demethylation of H3K4me3 through the PARylation, inhibition, and exclusion of the histone demethylase KDM5B; and (2) promoting the exclusion of H1 and the opening of promoter chromatin...
  10. doi PLU-1/JARID1B/KDM5B is required for embryonic survival and contributes to cell proliferation in the mammary gland and in ER+ breast cancer cells
    Steven Catchpole
    Breast Cancer Biology, King s College London, Guy s Hospital, London SE1 9RT, UK
    Int J Oncol 38:1267-77. 2011
    ..To investigate the function of the Jarid1B protein we examined the effects of deletion of the gene in mice...
  11. ncbi Retinoblastoma-binding protein 2-homolog 1: a retinoblastoma-binding protein downregulated in malignant melanomas
    Alexander Roesch
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Mod Pathol 18:1249-57. 2005
    ..Since a direct interaction of RBP2-H1 and pRb seems possible, the loss of RBP2-H1 may possibly contribute to uncontrolled growth in malignant melanomas...
  12. ncbi Re-expression of the retinoblastoma-binding protein 2-homolog 1 reveals tumor-suppressive functions in highly metastatic melanoma cells
    Alexander Roesch
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    J Invest Dermatol 126:1850-9. 2006
    ..Therefore, re-establishing of RBP2-H1 could evolve as an interesting novel approach in developing experimental treatments for metastatic melanomas...
  13. pmc JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer
    Yang Xiang
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology and Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Proc Natl Acad Sci U S A 104:19226-31. 2007
    ..Through bioinformatic and biochemical analysis, we identified JARID1B as a H3K4 demethylase...
  14. ncbi Dynamics of the Mrf-2 DNA-binding domain free and in complex with DNA
    L Zhu
    Division of Immunology, Beckman Institute of the City of Hope, Duarte, California 91010, USA
    Biochemistry 40:9142-50. 2001
    ....
  15. pmc Effect of L-proline on sake brewing and ethanol stress in Saccharomyces cerevisiae
    Hiroshi Takagi
    Department of Bioscience, Fukui Prefectural University, 4 1 1 Kenjojima, Matsuoka cho, Fukui 910 1195, Japan
    Appl Environ Microbiol 71:8656-62. 2005
    ..We constructed a novel sake yeast strain by disrupting the PUT1 gene, which is required for L-proline utilization, and replacing the wild-type PRO1 allele with the pro1(D154N) ..
  16. doi 1H, 13C, 15N backbone and side-chain resonance assignments of the Bright/ARID domain from the human histone demethylase JARID1B
    Wenming Yao
    Key Laboratory of Optical and Magnetic Resonance Spectroscopy, East China Normal University, Shanghai, 200062, China
    Biomol NMR Assign 3:85-7. 2009
    We report backbone and side-chain resonance assignments of the Bright/ARID domain from the human JARID1B protein. These assignments provide a basis for the detailed structural investigation of the interaction between DNA and ARID domains.
  17. pmc Roles of URE2 and GLN3 in the proline utilization pathway in Saccharomyces cerevisiae
    S Xu
    Department of Microbiology and Molecular Genetics, UMD New Jersey Medical School, Newark 07103
    Mol Cell Biol 15:2321-30. 1995
    ..grown in repressing or derepressing nitrogen sources, in the absence of the inducer proline, indicated that both PUT1 and PUT2 are regulated by nitrogen repression, although the effect on PUT2 is comparatively small...
  18. pmc Cha4p of Saccharomyces cerevisiae activates transcription via serine/threonine response elements
    S Holmberg
    Department of Genetics, University of Copenhagen, Denmark
    Genetics 144:467-78. 1996
    ..Molecular and genetic mapping positioned the cha4 locus 17 cM centromere proximal to put1 on chromosome XII...
  19. ncbi [Effect of mutations in PHO85 and PHO4 genes on utilization of proline in Saccharomyces cerevisiae yeasts]
    Iu G Popova
    Biological Research Institute, St Petersburg State University, St Petersburg, 198904 Russia
    Genetika 36:1622-8. 2000
    ..of the PH05 gene, a structural gene of acid phosphatase, seems to participate in the negative regulation of the PUT1 and PUT2 genes encoding enzymes of proline catabolism, proline oxidase and delta-pyrroline-5-carboxylate ..
  20. ncbi PLU-1 nuclear protein, which is upregulated in breast cancer, shows restricted expression in normal human adult tissues: a new cancer/testis antigen?
    Angela Barrett
    Breast Cancer Biology Group, Cancer Research UK, Guy s Hospital, London, United Kingdom
    Int J Cancer 101:581-8. 2002
    ..Our results suggest that the PLU-1 protein may belong to the class of testis/cancer antigens...
  21. doi Proline as a stress protectant in yeast: physiological functions, metabolic regulations, and biotechnological applications
    Hiroshi Takagi
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Nara, 630 0192, Japan
    Appl Microbiol Biotechnol 81:211-23. 2008
    ..cerevisiae cells that accumulate proline were constructed by disrupting the PUT1 gene involved in the degradation pathway and by expressing the mutant PRO1 gene encoding the feedback inhibition-..
  22. doi Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4
    Eric Metzger
    Urologische Klinik Frauenklinik und Zentrale Klinische Forschung, Klinikum der Universität Freiburg, Breisacherstrasse 66, Germany
    Nature 464:792-6. 2010
    ..Together, our data establish that androgen-dependent kinase signalling leads to the writing of the new chromatin mark H3T6ph, which in consequence prevents removal of active methyl marks from H3K4 during AR-stimulated gene expression...
  23. doi miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells
    Carolina Tarantino
    CEINGE Biotecnologie Avanzate, Via Comunale Margherita 452, 80145 Napoli, Italy
    FASEB J 24:3255-63. 2010
    ..Among the candidate targets emerging from this analysis, we found three genes, Smarca5, Jarid1b, and Sirt1, previously demonstrated to be involved in sustaining the undifferentiated phenotype in ESCs...
  24. pmc RNAi screen identifies Jarid1b as a major regulator of mouse HSC activity
    Sonia Cellot
    Institute for Research in Immunology and Cancer, Universite de Montreal, Montreal, QC, Canada
    Blood 122:1545-55. 2013
    ..stem cell (HSC) behavior, we performed an in vivo RNAi-based functional screen and demonstrated that Jarid1b and Jhdm1f play opposing roles in regulation of HSC activity...
  25. doi Spatiotemporal expression of DNA demethylation enzymes and histone demethylases in bovine embryos
    Florence Pagé-Larivière
    Centre de Recherche en Biologie de la Reproduction, Faculté des sciences de l agriculture et de l alimentation, Departement des Sciences Animales, Universite Laval, Quebec, QC, Canada, G1V 0A6
    Cell Reprogram 16:40-53. 2014
    ..Total RNA for AICDA, TET1, TET2, TET3, KDM3A, KDM4A, KDM4C, and KDM5B was extracted, reverse transcribed into cDNA, and amplified by real-time PCR...
  26. doi Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development
    Gen Bao Shao
    Department of Biology, School of Medical Science and Laboratory Medicine, Jiangsu University, 301 XueFu, Zhenjiang, 212013, China
    In Vitro Cell Dev Biol Anim 50:603-13. 2014
    ..changes of H3K4me and its key regulators (Ash1l, Ash2l, Kmt2a, Kmt2b, Kmt2c, Setd1a, Setd7, Kdm1a, Kdm1b, Kdm5a, Kdm5b, Kdm5c, and Kdm5d) in mouse oocytes and preimplantation embryos...
  27. pmc A stress-induced early innate response causes multidrug tolerance in melanoma
    D Ravindran Menon
    Cancer Biology Unit, Department of Dermatology, Medical University of Graz, Graz, Austria
    Oncogene 34:4448-59. 2015
    ..Knockdown of CD271 or KDM5B decreases transition into the IDTC state substantially but does not prevent it...
  28. doi Overexpressed KDM5B is associated with the progression of glioma and promotes glioma cell growth via downregulating p21
    Bin Dai
    Department of Neurosurgery, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China
    Biochem Biophys Res Commun 454:221-7. 2014
    ..Upregulation of lysine (K)-specific demethylase 5B (KDM5B) has been reported in a variety of malignant tumors. However, the impact of KDM5B in glioma remains unclear...
  29. pmc Honokiol inhibits melanoma stem cells by targeting notch signaling
    Gaurav Kaushik
    Departments of Surgery, The University of Kansas Medical Center, Kansas City, Kansas
    Mol Carcinog 54:1710-21. 2015
    ..Western blot analyses also demonstrated reduction in stem cell markers CD271, CD166, Jarid1b, and ABCB5. We next examined the effect of HNK on Notch signaling, a pathway involved in stem cell self-renewal...
  30. pmc Impairment of preimplantation porcine embryo development by histone demethylase KDM5B knockdown through disturbance of bivalent H3K4me3-H3K27me3 modifications
    Jiaojiao Huang
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China University of Chinese Academy of Sciences, Beijing, China
    Biol Reprod 92:72. 2015
    KDM5B (JARID1B/PLU1) is a H3K4me2/3 histone demethylase that is implicated in cancer development and proliferation and is also indispensable for embryonic stem cell self-renewal, cell fate, and murine embryonic development...
  31. pmc JARID1B promotes metastasis and epithelial-mesenchymal transition via PTEN/AKT signaling in hepatocellular carcinoma cells
    Bo Tang
    Department of Hepatobiliary Surgery, Guilin Medical University, Affiliated Hospital, Guilin, Guangxi, People s Republic of China
    Oncotarget 6:12723-39. 2015
    b>JARID1B is a member of the family of JmjC domain-containing proteins that removes methyl residues from methylated lysine 4 on histone H3 lysine 4 (H3K4)...
  32. pmc JARID1B Expression Plays a Critical Role in Chemoresistance and Stem Cell-Like Phenotype of Neuroblastoma Cells
    Yung Ting Kuo
    Department of Pediatrics, Taipei Medical University Shuang Ho Hospital, Taipei, Taiwan Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
    PLoS ONE 10:e0125343. 2015
    ..This necessitates the need for novel effective therapeutic strategy. JARID1B, also known as KDM5B, is a histone lysine demethylase, identified as an oncogene in many cancer types...
  33. pmc Disrupted intricacy of histone H3K4 methylation in neurodevelopmental disorders
    Christina N Vallianatos
    Department of Human Genetics, University of Michigan, 5815 Medical Science II, Ann Arbor, MI 48109, USA
    Epigenomics 7:503-19. 2015
    ..We describe four H3K4me methyltransferases (KMT2A, KMT2C, KMT2D, KMT2F), four demethylases (KDM1A, KDM5A, KDM5B, KDM5C), and two reader proteins (PHF21A, PHF8) mutated in neurodevelopmental disorders...
  34. doi Immunohistochemical detection and clinicopathological significance of JARID1B/KDM5B and P16 expression in invasive ductal carcinoma of the breast
    L H Zhao
    Department of Pathology, Beijing Tongren Hospital, Capital Medical University, Dongcheng District, Beijing, China
    Genet Mol Res 14:5417-26. 2015
    ..of this study were to investigate the expression of the H3K4 demethylase, jumonji AT-rich interactive domain 1B (JARID1B/KDM5B) and of p16 (multiple tumor suppressor gene MTS1) in breast cancer tissue and determine its ..
  35. pmc The H3K4-Methyl Epigenome Regulates Leukemia Stem Cell Oncogenic Potential
    Stephen H K Wong
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cancer Cell 28:198-209. 2015
    ..The H3K4-specific demethylase KDM5B negatively regulates leukemogenesis in murine and human MLL-rearranged AML cells, demonstrating a crucial role for ..
  36. doi Histone Peptide Recognition by KDM5B-PHD1: A Case Study
    Suvobrata Chakravarty
    Department of Chemistry and Biochemistry, South Dakota State University, Box 2202, SAV367, Brookings, South Dakota 57007, United States
    Biochemistry 54:5766-80. 2015
    ..This study showcases reader-histone peptide interactions in the context of residue conservation, energetic contributions, interfacial packing, and sequence-based reader subtype predictability...
  37. pmc Epigenetic Control of the Bone-master Runx2 Gene during Osteoblast-lineage Commitment by the Histone Demethylase JARID1B/KDM5B
    Adriana Rojas
    From the Center for Biomedical Research, Faculty of Biological Sciences and Faculty of Medicine, Universidad Andres Bello, Santiago, 8370146, Chile, Faculty of Sciences, Universidad de Chile, Santiago, 7800003, Chile, FONDAP Center for Genome Regulation, Santiago, Chile
    J Biol Chem 290:28329-42. 2015
    ..and Polycomb group complexes together with histone arginine methylases like PRMT5 and lysine demethylases like JARID1B/KDM5B...
  38. doi MicroRNAs regulate KDM5 histone demethylases in breast cancer cells
    Hélène Denis
    Laboratory of Cancer Epigenetics, Faculty of Medicine, Universite Libre de Bruxelles, Brussels, Belgium
    Mol Biosyst 12:404-13. 2016
    ..We further identified KDM5B, a histone demethylase known to be involved in breast cancer tumorigenesis, as a target of miR-137...
  39. pmc Transcriptional Regulation of JARID1B/KDM5B Histone Demethylase by Ikaros, Histone Deacetylase 1 (HDAC1), and Casein Kinase 2 (CK2) in B-cell Acute Lymphoblastic Leukemia
    Haijun Wang
    From the Department of Pathology, Xinxiang Medical University, Xinxiang 453003, Henan, China, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033
    J Biol Chem 291:4004-18. 2016
    ..Here, we report that Ikaros represses transcription of the histone H3K4 demethylase, JARID1B (KDM5B). Transcriptional repression of JARID1B is associated with increased global levels of H3K4 trimethylation...
  40. pmc Inhibition of the histone demethylase Kdm5b promotes neurogenesis and derepresses Reln (reelin) in neural stem cells from the adult subventricular zone of mice
    Qiong Zhou
    Center for Neuroscience and Regenerative Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814
    Mol Biol Cell 27:627-39. 2016
    ..We show that the histone demethylase enzyme Kdm5b (Jarid1b) negatively regulates neurogenesis from adult subventricular zone (SVZ) neural stem cells (NSCs) in culture...
  41. doi Proline accumulation protects Saccharomyces cerevisiae cells in stationary phase from ethanol stress by reducing reactive oxygen species levels
    Hiroshi Takagi
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, Nara, Japan
    Yeast 33:355-63. 2016
    ..When cultured in YPD medium, there was a significant accumulation of proline in the put1 mutant strain, which is deficient in proline oxidase, in the stationary phase...
  42. pmc Synchronized Targeting of Notch and ERBB Signaling Suppresses Melanoma Tumor Growth through Inhibition of Notch1 and ERBB3
    Keman Zhang
    Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    J Invest Dermatol 136:464-72. 2016
    ..Blockade of both Notch and ERBB signaling inhibits the slow cycling JARID1B-positive cell population, which is critical for long-term maintenance of melanoma growth...
  43. doi Structural analysis of human KDM5B guides histone demethylase inhibitor development
    Catrine Johansson
    Structural Genomics Consortium, University of Oxford, Headington, UK
    Nat Chem Biol 12:539-45. 2016
    ..Here we report crystal structures of the catalytic core of the human KDM5B enzyme in complex with three inhibitor chemotypes...
  44. doi Hypoxic reprograming of H3K27me3 and H3K4me3 at the INK4A locus
    Soojeong Chang
    Department of Life Science, University of Seoul, Korea
    FEBS Lett 590:3407-3415. 2016
    ..enhanced the active histone mark H3K4me3 at the INK4a locus by inhibiting the H3K4me3 demethylases JARID1A and JARID1B. Therefore, this study demonstrates that the O2 concentration in the microenvironment differentially ..
  45. doi Allelic reprogramming of the histone modification H3K4me3 in early mammalian development
    Bingjie Zhang
    Center for Stem Cell Biology and Regenerative Medicine, MOE Key Laboratory of Bioinformatics, THU PKU Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China
    Nature 537:553-557. 2016
    ..Finally, downregulation of H3K4me3 in full-grown oocytes by overexpression of the H3K4me3 demethylase KDM5B is associated with defects in genome silencing...
  46. ncbi miR-194 inhibits gastric cancer cell proliferation and tumorigenesis by targeting KDM5B
    J Bao
    Department of Nuclear Medicine, Department of Gastroenterology Cangzhou Central Hospital, Cangzhou, Hebei, China
    Eur Rev Med Pharmacol Sci 20:4487-4493. 2016
    ..The aim of the present study was to examine the expression pattern of miR-194 in gastric cancer (GC) and its biological role in tumor progression...
  47. pmc Histone demethylase lysine demethylase 5B in development and cancer
    Mengjiao Han
    Department of Medical Oncology, Key Laboratory of Biotherapy in Zhejiang, Sir RunRun Shaw Hospital, Medical School of Zhejiang University, China
    Oncotarget . 2016
    ..KDM5B (lysine demethylase 5B, also called JARID1B or PLU-1) encodes the histone H3 lysine4 (H3K4) demethylase and exhibits a strong transcriptional repression ..
  48. pmc KDM5 lysine demethylases are involved in maintenance of 3'UTR length
    Lauren P Blair
    Department of Pathology, Yale School of Medicine, New Haven, CT 06520, USA
    Sci Adv 2:e1501662. 2016
    ..Furthermore, its mammalian homolog KDM5B (also known as JARID1B or PLU1), but not KDM5A (also known as JARID1A or RBP2), promotes shortening of CCND1 transcript in breast ..
  49. pmc Rapamycin treatment results in GATA factor-independent hyperphosphorylation of the proline utilization pathway activator in Saccharomyces cerevisiae
    Deepti Saxena
    Department of Microbiology and Molecular Genetics, UMDNJ New Jersey Medical School, Newark 07101 1709, USA
    Eukaryot Cell 2:552-9. 2003
    ..Gln3p and Nil1p) and pathway-specific (Put3p) activators to rapamycin-induced expression of the target gene PUT1 were also examined...
  50. pmc Tomato QM-like protein protects Saccharomyces cerevisiae cells against oxidative stress by regulating intracellular proline levels
    Changbin Chen
    Institute for Plant Genomics and Biotechnology, Department of Plant Pathology and Microbiology, Texas A and M University, 2123 TAMU, College Station, TX 77843, USA
    Appl Environ Microbiol 72:4001-6. 2006
    ..We altered intracellular proline levels by overexpressing the proline dehydrogenase gene (PUT1) of S. cerevisiae. Put1p performs the first enzymatic step of proline degradation in S. cerevisiae...
  51. ncbi The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases
    Shigeki Iwase
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Cell 128:1077-88. 2007
    ..Our findings thus identify a family of H3K4me3 demethylases and uncover a critical link between histone modifications and XLMR...
  52. ncbi Breast cancer associated transcriptional repressor PLU-1/JARID1B interacts directly with histone deacetylases
    Angela Barrett
    Cancer Research UK Breast Cancer Biology Group, King s College London School of Medicine, Guy s Hospital, London, United Kingdom
    Int J Cancer 121:265-75. 2007
    The PLU-1/JARID1B nuclear protein, which is expressed in a high proportion of breast cancers, but shows restricted expression elsewhere, belongs to the ARID family of proteins, known to play important roles in development, ..
  53. doi Identification of circulating placental mRNA in maternal blood of pregnancies affected with fetal congenital heart diseases at the second trimester of pregnancy: implications for early molecular screening
    Diego Arcelli
    Molecular Oncology Lab, Functional Genomics and Bioinformatics unit, Dermopathic Institute of the Immacolata IDI IRCCS, Via dei Monti di Creta 104, 00167 Rome, Italy
    Prenat Diagn 30:229-34. 2010
    ..To investigate whether a significantly aberrant expression of circulating placental mRNA genes related with cardiogenesis can be detected at the second trimester of pregnancy...
  54. pmc A distinctive gene expression fingerprint in mentally retarded male patients reflects disease-causing defects in the histone demethylase KDM5C
    Lars R Jensen
    Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    Pathogenetics 3:2. 2010
    ..Specific transcriptional targets of KDM5C, however, are still unknown and the effects of KDM5C deficiency on gene expression have not yet been investigated...
  55. pmc Selective targeting of histone methylation
    Abul B M M K Islam
    Research Unit on Biomedical Informatics, Department of Experimental Health and Sciences, PRBB, Universitat Pompeu Fabra, Barcelona, Spain
    Cell Cycle 10:413-24. 2011
    ..Specifically, genomic sites of the H3K4 histone demethylase KDM5A become accessible to its homolog KDM5B in cells with a lowered KDM5A level...
  56. pmc The von Hippel-Lindau tumor suppressor protein regulates gene expression and tumor growth through histone demethylase JARID1C
    X Niu
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Oncogene 31:776-86. 2012
    ..In addition, we demonstrated that only loss of JARID1C, not JARID1A or JARID1B, abolished the difference of H3K4Me3 levels between VHL-/- and VHL+/+ cells, and JARID1C displayed HIF-dependent ..
  57. doi Polychlorinated biphenyls affect histone modification pattern in early development of rats: a role for androgen receptor-dependent modulation?
    Lavinia Casati
    Department of Endocrinology, Pathophysiology and Applied Biology, INBB Research Unit, University of Milano, Milano, Italy
    Epigenomics 4:101-12. 2012
    ..Early-life exposure to polychlorinated biphenyls (PCBs) modifies sex steroid enzymes and receptor transcription patterns. Steroid receptors, such as androgen receptor (AR), function as coregulators of histone modification enzymes...
  58. doi Improving putrescine production by Corynebacterium glutamicum by fine-tuning ornithine transcarbamoylase activity using a plasmid addiction system
    Jens Schneider
    Genetics of Prokaryotes, Department of Biology and CeBiTec, Bielefeld University, P O Box 100131, 33501 Bielefeld, Germany
    Appl Microbiol Biotechnol 95:169-78. 2012
    ..Previously, we constructed the putrescine-producing strain PUT1 by deletion of argF, the gene for ornithine transcarbamoylase (OTC), and argR, encoding the L-arginine repressor, ..
  59. pmc Transcriptional regulation of rod photoreceptor homeostasis revealed by in vivo NRL targetome analysis
    Hong Hao
    Neurobiology Neurodegeneration and Repair Laboratory, National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Genet 8:e1002649. 2012
    ..We also identified histone demethylase Kdm5b as a novel secondary node in NRL transcriptional hierarchy...
  60. doi Preferential expression of cancer/testis genes in cancer stem-like cells: proposal of a novel sub-category, cancer/testis/stem gene
    R Yamada
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Tissue Antigens 81:428-34. 2013
    ..Thus, considerable numbers of CT genes showed preferential expression in CSCs/CICs. We therefore propose a novel sub-category of CT genes in this report: cancer/testis/stem (CTS) genes...
  61. pmc Androgen receptor activation by polychlorinated biphenyls: epigenetic effects mediated by the histone demethylase Jarid1b
    Lavinia Casati
    Department of Pharmacological and Biomolecular Sciences University of Milan Milano, Italy
    Epigenetics 8:1061-8. 2013
    ..We found that PCBs activate AR transcriptional activity and that this effect is potentiated by the demethylase Jarid1b, a histone demethylase that catalyzes the removal of trimethylation of lysine 4 on histone H3 (H3K4me3), induced ..
  62. pmc Phenformin enhances the therapeutic benefit of BRAF(V600E) inhibition in melanoma
    Ping Yuan
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129
    Proc Natl Acad Sci U S A 110:18226-31. 2013
    ..Noticeably, phenformin selectively targeted subpopulations of cells expressing JARID1B, a marker for slow cycling melanoma cells, whereas PLX4720 selectively targeted JARID1B-negative cells...
  63. pmc SIRT1 is highly expressed in brain metastasis tissues of non-small cell lung cancer (NSCLC) and in positive regulation of NSCLC cell migration
    Lin Han
    The Experimental Animal Center, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences Shanghai, China
    Int J Clin Exp Pathol 6:2357-65. 2013
    ..The screening results showed that knockdown of 2 genes (KDM5B and SIRT1) dramatically and specifically inhibits A549 migration but not affects the proliferation, which was ..
  64. doi Fumonisin B1 induces global DNA hypomethylation in HepG2 cells - An alternative mechanism of action
    Anil Chuturgoon
    Discipline of Medical Biochemistry, School of Laboratory Medicine and Medical Sciences, University of KwaZulu Natal, Durban, South Africa Electronic address
    Toxicology 315:65-9. 2014
    ..of DNMT1, DNMT3A and DNMT3B, and significantly up regulated the demethylases (MBD2 expression and activity, and KDM5B and KDM5C expression)...
  65. pmc The histone-H3K4-specific demethylase KDM5B binds to its substrate and product through distinct PHD fingers
    Brianna J Klein
    Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Cell Rep 6:325-35. 2014
    The histone lysine demethylase KDM5B regulates gene transcription and cell differentiation and is implicated in carcinogenesis. It contains multiple conserved chromatin-associated domains, including three PHD fingers of unknown function...
  66. doi Inverse regulation of melanoma growth and migration by Orai1/STIM2-dependent calcium entry
    Hedwig Stanisz
    Department of Dermatology, Venereology and Allergology, University Hospital of the Saarland, Homburg, Germany
    Pigment Cell Melanoma Res 27:442-53. 2014
    ..Accordingly, markers for a non-proliferative, tumor-maintaining phenotype such as JARID1B and Brn2 decreased...
  67. pmc The breast cancer oncogene EMSY represses transcription of antimetastatic microRNA miR-31
    Emmanuelle Viré
    Gurdon Institute and Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Mol Cell 53:806-18. 2014
    ..by the DNA binding factor ETS-1, and it represses miR-31 transcription by delivering the H3K4me3 demethylase JARID1b/PLU-1/KDM5B...
  68. pmc Histone demethylase KDM5B is a key regulator of genome stability
    Xin Li
    2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Key Laboratory of Medical Epigenetics, Department of Biochemistry and Molecular Biology, Tianjin Medical University, Tianjin 300070, China and
    Proc Natl Acad Sci U S A 111:7096-101. 2014
    ..Here we report the identification and characterization of lysine-specific histone demethylase 5B (KDM5B), a member of the JmjC domain-containing histone demethylases, as an important player in multiple aspects of DNA ..
  69. pmc Histone demethylase jumonji AT-rich interactive domain 1B (JARID1B) controls mammary gland development by regulating key developmental and lineage specification genes
    Mike Ran Zou
    From the Department of Pathology, Yale School of Medicine, New Haven, Connecticut 06520
    J Biol Chem 289:17620-33. 2014
    The JmjC domain-containing H3K4 histone demethylase jumonji AT-rich interactive domain 1B (JARID1B) (also known as KDM5B and PLU1) is overexpressed in breast cancer and is a potential target for breast cancer treatment...
  70. doi The KDM5 family of histone demethylases as targets in oncology drug discovery
    Peter Birk Rasmussen
    EpiTherapeutics ApS, Ole Maaløes Vej 3, DK 2200 Copenhagen, Denmark
    Epigenomics 6:277-86. 2014
    ..In particular, KDM5A (JARID1A/RBP2) and KDM5B (JARID1B/PLU1) contribute to cancer cell proliferation, reduce the expression of tumor suppressor genes, promote the ..
  71. pmc Bivalent histone modifications during tooth development
    Li Wei Zheng
    1 State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China 2 Department of Orthopedics, Johns Hopkins University, Baltimore, USA
    Int J Oral Sci 6:205-11. 2014
    ..methylation or demethylation transferases in tooth organ development, we measured the expression of SET7, EZH2, KDM5B and JMJD3 via immunohistochemistry and quantitative polymerase chain reaction (qPCR) analysis in the first molar ..
  72. pmc The histone demethylase Jarid1b is required for hematopoietic stem cell self-renewal in mice
    Morag H Stewart
    Program in Cellular and Molecular Medicine, Boston Children s Hospital, Boston, MA Department of Stem Cell and Regenerative Medicine, Harvard University, Cambridge, MA
    Blood 125:2075-8. 2015
    b>Jarid1b/KDM5b is a histone demethylase that regulates self-renewal and differentiation in stem cells and cancer; however, its function in hematopoiesis is unclear...
  73. pmc Overexpression of JARID1B is associated with poor prognosis and chemotherapy resistance in epithelial ovarian cancer
    Lishuang Wang
    Department of Gynecology and Obstetrics, The Fourth Affiliated Hospital of Harbin Medical University, Yiyuan Road 37, Nangang District, Harbin, 150001, China
    Tumour Biol 36:2465-72. 2015
    b>JARID1B, a histone demethylase, has been reported to be highly expressed in various human cancers...
  74. ncbi Assessment of melanoma-initiating cell markers and conventional parameters in sentinel lymph nodes of malignant melanoma
    Norihiro Suzuki
    Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Acta Med Okayama 69:17-27. 2015
    ..the expressions of gp100, MART-1 and tyrosinase mRNA for routine diagnosis and those of ABCB5, CD133, nestin, KDM5B, NGFR and RANK mRNA as MIC markers...
  75. doi Vemurafenib resistance selects for highly malignant brain and lung-metastasizing melanoma cells
    Inna Zubrilov
    Department of Cell Research and Immunology, The George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    Cancer Lett 361:86-96. 2015
    ..Resistant cells expressed higher levels of genes coding for cancer stem cell markers (JARID1B, CD271 and Fibronectin) as well as genes involved in drug resistance (ABCG2), cell invasion and promotion of ..
  76. doi PLU-1/JARID1B overexpression predicts proliferation properties in head and neck squamous cell carcinoma
    Zhibin Cui
    Department of Oral and Maxillofacial Surgery, Ninth People s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P R China
    Oncol Rep 33:2454-60. 2015
    PLU-1/JARID1B (jumonji AT rich interactive domain 1B) is one of the testis cancer antigens and functions as a histone demethylase in the regulation of various human types of cancers...
  77. ncbi Characterisation and developmental expression of mouse Plu-1, a homologue of a human nuclear protein (PLU-1) which is specifically up-regulated in breast cancer
    Bente Madsen
    Breast Cancer Biology Group, Guy s Hospital, St Thomas Street, London SE1 9RT, UK
    Gene Expr Patterns 2:275-82. 2002
    ..Thus Plu-1 appears to play an important role in mouse embryonic development which may involve interaction with Pax9 and Bf-1...
  78. pmc Reactive oxygen species homeostasis and virulence of the fungal pathogen Cryptococcus neoformans requires an intact proline catabolism pathway
    I Russel Lee
    Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland 4072, Australia
    Genetics 194:421-33. 2013
    ..In the genome of the fungal pathogen Cryptococcus neoformans, there are two paralogs (PUT1 and PUT5) that encode proline oxidases and a single ortholog (PUT2) that encodes P5C dehydrogenase...
  79. pmc The histone demethylase Jarid1b ensures faithful mouse development by protecting developmental genes from aberrant H3K4me3
    Mareike Albert
    Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark
    PLoS Genet 9:e1003461. 2013
    ..Here we show that deletion of the H3K4me2/3 histone demethylase Jarid1b (Kdm5b/Plu1) results in major neonatal lethality due to respiratory failure...
  80. pmc Unliganded progesterone receptor-mediated targeting of an RNA-containing repressive complex silences a subset of hormone-inducible genes
    Guillermo Pablo Vicent
    Centre for Genomic Regulation CRG, E 08003 Barcelona, Spain
    Genes Dev 27:1179-97. 2013
    ..1), HDAC1/2, CoREST (corepressor for REST [RE1 {neuronal repressor element 1} silencing transcription factor]), KDM5B, and the RNA SRA (steroid receptor RNA activator) to 20% of hormone-inducible genes, keeping these genes silenced ..
  81. pmc The human papillomavirus type 16 E7 oncoprotein induces a transcriptional repressor complex on the Toll-like receptor 9 promoter
    Uzma A Hasan
    Infections and Cancer Biology Group, International Agency for Research on Cancer, Lyon 69008, France
    J Exp Med 210:1369-87. 2013
    ..The E7-mediated transcriptional complex also recruited the histone demethylase JARID1B and histone deacetylase HDAC1...
  82. pmc KDM5B histone demethylase controls epithelial-mesenchymal transition of cancer cells by regulating the expression of the microRNA-200 family
    Zanabazar Enkhbaatar
    Division of Functional Genomics, Cancer Research Institute, Kanazawa University, Ishikawa, Japan
    Cell Cycle 12:2100-12. 2013
    ..In this study, we discovered that ectopic expression of KDM5B, a histone H3 lysine 4 (H3K4) demethylase, promoted epithelial-mesenchymal transition (EMT) of cancer cells...
  83. pmc Identification and characterization of FGF2-dependent mRNA: microRNA networks during lens fiber cell differentiation
    Louise Wolf
    Department of Genetics, Albert Einstein College of Medicine, Bronx, New York 10461
    G3 (Bethesda) 3:2239-55. 2013
    ..factors); Cnot6, Cpsf6, Dicer1, and Tnrc6b (RNA to miRNA processing); and Ash1l, Med1/PBP, and Kdm5b/Jarid1b/Plu1 (chromatin remodeling)...
  84. ncbi PLU-1, a transcriptional repressor and putative testis-cancer antigen, has a specific expression and localisation pattern during meiosis
    Bente Madsen
    Breast Cancer Biology Group, Cancer Research UK formerly Imperial Cancer Research Fund, Guy s Hospital, St Thomas Street, London SE1 9RT, UK
    Chromosoma 112:124-32. 2003
    ..Our data point to a role for PLU-1 in meiotic transcription, which may be restricted to certain meiotic stages and may be mediated by the ability of this protein to associate with the chromatin...
  85. doi Depletion of JARID1B induces cellular senescence in human colorectal cancer
    Katsuya Ohta
    Department of Frontier Science for Cancer and Chemotherapy, Osaka University, Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Int J Oncol 42:1212-8. 2013
    ..this study, we investigated the functional roles of the H3K4 demethylase, jumonji, AT rich interactive domain 1B (JARID1B), an epigenetic factor required for the continuous cell growth of melanomas, in CRC...
  86. pmc Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen
    Joyce Sayegh
    Department of Pathology, Yale School of Medicine, New Haven, CT 06520, USA
    J Biol Chem 288:9408-17. 2013
    b>JARID1B (also known as KDM5B or PLU1) is a member of the JARID1 family of histone lysine demethylases responsible for the demethylation of trimethylated lysine 27 in histone H3 (H3K4me3), a mark for actively transcribed genes...
  87. pmc Novel pancreatic endocrine maturation pathways identified by genomic profiling and causal reasoning
    Alex Gutteridge
    Pfizer Regenerative Medicine, Cambridge, United Kingdom
    PLoS ONE 8:e56024. 2013
    ..Our causal reasoning algorithm suggested the involvement of novel gene networks, such as NEUROG3/E2F1/KDM5B and SOCS3/STAT3/IL-6, in endocrine cell development We experimentally investigated the role of the top-ranked ..
  88. pmc Connexin 26 is down-regulated by KDM5B in the progression of bladder cancer
    Xin Li
    Urologic Institute of PLA, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
    Int J Mol Sci 14:7866-79. 2013
    Connexin 26 (Cx26) expression is down-regulated and KDM5B (H3K4 demethylase) is up-regulated in the progression of bladder cancer, suggesting that Cx26 expression may be down-regulated by KDM5B in bladder cancer...
  89. pmc Overcoming intrinsic multidrug resistance in melanoma by blocking the mitochondrial respiratory chain of slow-cycling JARID1B(high) cells
    Alexander Roesch
    Department of Dermatology, The Saarland University Hospital, D 66421 Homburg Saar, Germany
    Cancer Cell 23:811-25. 2013
    ..leads to enrichment of slow-cycling, long-term tumor-maintaining melanoma cells expressing the H3K4-demethylase JARID1B/KDM5B/PLU-1...
  90. pmc DLK1: a novel target for immunotherapeutic remodeling of the tumor blood vasculature
    Nina Chi Sabins
    Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Mol Ther 21:1958-68. 2013
    ..Vaccination against DLK1 also yielded (i) dramatic reductions in Jarid1B(+), CD133(+), and CD44(+) (hypoxia-responsive) stromal cell populations, (ii) enhanced tumor cell apoptosis, and (..
  91. pmc The Saccharomyces cerevisiae PUT3 activator protein associates with proline-specific upstream activation sequences
    A H Siddiqui
    Department of Microbiology and Molecular Genetics, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark 07103
    Mol Cell Biol 9:4706-12. 1989
    The PUT1 and PUT2 genes encoding the enzymes of the proline utilization pathway of Saccharomyces cerevisiae are induced by proline and activated by the product of the PUT3 gene...
  92. doi Overexpression of Jumonji AT-rich interactive domain 1B and PHD finger protein 2 is involved in the progression of esophageal squamous cell carcinoma
    Ling Ling Sun
    Institute of Oncologic Pathology, Medical College of Shantou University, People s Republic of China
    Acta Histochem 115:56-62. 2013
    Jumonji AT-rich interactive domain 1B (JARID1B) and PHD finger protein 2 (PHF2), members of the histone demethylases, have been found to be involved in many types of tumors...
  93. doi Systematic knockdown of epigenetic enzymes identifies a novel histone demethylase PHF8 overexpressed in prostate cancer with an impact on cell proliferation, migration and invasion
    M Bjorkman
    Medical Biotechnology, VTT Technical Research Centre of Finland, and Center for Biotechnology, University of Turku and Abo Akademi University, Turku, Finland
    Oncogene 31:3444-56. 2012
    ..Our results show that the KDMs JARID1B, PHF8, KDM3A, KDM3B and KDM4A were highly expressed in clinical PrCa samples...
  94. pmc Enhancement of the proline and nitric oxide synthetic pathway improves fermentation ability under multiple baking-associated stress conditions in industrial baker's yeast
    Yu Sasano
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Nara 630 0192, Japan
    Microb Cell Fact 11:40. 2012
    ..yeast strain that is involved in stress-induced nitric oxide (NO) synthesis from proline via proline oxidase Put1 and N-acetyltransferase Mpr1...
  95. ncbi Kinetic and phylogenetic analysis of plant polyamine uptake transporters
    Vaishali Mulangi
    Department of Biological Sciences, Bowling Green State University, Bowling Green, OH 43403, USA
    Planta 236:1261-73. 2012
    The rice gene Polyamine Uptake Transporter1 (PUT1) was originally identified based on its homology to the polyamine uptake transporters LmPOT1 and TcPAT12 in Leishmania major and Trypanosoma cruzi, respectively...
  96. pmc Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis
    Lei Shi
    Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing 100191, China
    Proc Natl Acad Sci U S A 108:7541-6. 2011
    ....
  97. pmc Compensatory functions of histone deacetylase 1 (HDAC1) and HDAC2 regulate transcription and apoptosis during mouse oocyte development
    Pengpeng Ma
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 109:E481-9. 2012
    ..The decrease in H3K4 methylation is likely a result of increased expression of Kdm5b because RNAi-mediated targeting of Kdm5b in double-mutant oocytes results in an increase in H3K4 methylation...
  98. pmc Histone demethylase KDM5B collaborates with TFAP2C and Myc to repress the cell cycle inhibitor p21(cip) (CDKN1A)
    Ping Pui Wong
    Centre for Tumour Biology, Bart s Cancer Institute, Queen Mary University of London, London, United Kingdom
    Mol Cell Biol 32:1633-44. 2012
    ..containing TFAP2C, the oncoprotein Myc, and the trimethylated lysine 4 of histone H3 (H3K4me3) demethylase, KDM5B. We demonstrated that while TFAP2C and Myc can downregulate the CDKN1A promoter independently, KDM5B acts as a ..
  99. doi Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor
    Line H Kristensen
    Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark
    FEBS J 279:1905-14. 2012
    ..KDM5B/Jarid1B/PLU1 is an H3K4me3/me2-specific lysine demethylase belonging to the JmjC domain-containing family of histone ..
  100. pmc H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence
    Agustin Chicas
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Proc Natl Acad Sci U S A 109:8971-6. 2012
    ..patterns--loss of H3K4 methylation--to the retinoblastoma tumor suppressor and the H3K4 demethylases Jarid1a and Jarid1b. Our results show that Jarid1a/b-mediated H3K4 demethylation contributes to silencing of retinoblastoma target ..
  101. doi JARID1B protein expression and prognostic implications in uveal melanoma
    Patrik Radberger
    Karolinska Institutet, Stockholm, Sweden
    Invest Ophthalmol Vis Sci 53:4442-9. 2012
    It has been suggested recently that stem cell marker expression of jumonji AT-rich interactive domain 1B (JARID1B) is required for continuous tumor growth and maintenance in human cutaneous melanoma cells...

Research Grants11

  1. Amato J Giaccia; Fiscal Year: 2014
    ..This has led to the discovery that the transcriptional repressor JARID1B is a direct p53 target...
  2. WILLIAM L KRAUS; Fiscal Year: 2016
    ..PARylation on the activity and function of chromatin-regulating proteins, including the histone demethylase KDM5B and the histone methyltransferase Ezh2;and (3) the mechanisms by which NAD+ production by the nuclear NAD+ ..
  3. MEENHARD F HERLYN; Fiscal Year: 2015
    ..Cells of this sub-population are characterized by expression of the histone 3 K4 demethylase JARID1B, which is a member of the highly conserved jumonji family of chromatin regulators...
  4. CELL CYCLE CHECKPOINT CONTROL IN RESPONSE TO DNA DAMAGE
    Nancy C Walworth; Fiscal Year: 2011
    ..Our studies make use of the excellent genetics of this organism to elucidate mechanisms that are universally important for governing cell division in the face of DNA damage. ..
  5. MEENHARD F HERLYN; Fiscal Year: 2015
    ..They are characterized by expression ofthe histone 3 K4 demethylase JARID1B. In this proposal we will characterize the signaling mechanisms mediating therapy resistance in JARID1B+ cells ..
  6. Using Synthetic Lethality to Select Cancer Drug Targets
    William Kaelin; Fiscal Year: 2005
    ..Moreover, they may establish a new paradigm for the selection of anticancer drug targets based on inactivating mutations of TSG. ..
  7. Real-Time Imaging of Hypoxia based on VHL Activity
    William Kaelin; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  8. 2006 Cancer Model Mechanisms
    William Kaelin; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  9. A Luciferase Fusion Protein Library to Identify & Monitor Ubiquitylation Targets
    William Kaelin; Fiscal Year: 2008
    ..Reisolation of HIF in aims 2 and 3 would constitute proof of concept with respect to the potential utility of this approach. ..
  10. HYPOXIA AND GENE REPRESSION
    Amato Giaccia; Fiscal Year: 2009
    ..We will test these hypotheses through a combination of genetic and biochemical approaches in cell lines and in mice. ..
  11. CTGF in Pancreatic Tumor Growth
    Amato J Giaccia; Fiscal Year: 2010
    ..In summary, the proposed studies are intended to address an important mechanism by which CTGF affects tumor progression in pancreatic cancers and to determine how effective it is in combination therapy to bring it to the clinic. ..