KCTD3

Summary

Gene Symbol: KCTD3
Description: potassium channel tetramerization domain containing 3
Alias: NY-REN-45, BTB/POZ domain-containing protein KCTD3, NY-REN-45 antigen, potassium channel tetramerisation domain containing 3, renal carcinoma antigen NY-REN-45
Species: human

Top Publications

  1. doi Accelerating novel candidate gene discovery in neurogenetic disorders via whole-exome sequencing of prescreened multiplex consanguineous families
    Anas M Alazami
    Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia
    Cell Rep 10:148-61. 2015
  2. pmc Clinical exome sequencing: results from 2819 samples reflecting 1000 families
    Daniel Trujillano
    Centogene AG, Rostock, Germany
    Eur J Hum Genet 25:176-182. 2017
  3. doi A Genomic and Protein-Protein Interaction Analyses of Nonsyndromic Hearing Impairment in Cameroon Using Targeted Genomic Enrichment and Massively Parallel Sequencing
    Kamogelo Lebeko
    1 Division of Human Genetics, Department of Pathology, Faculty of Health Sciences University of Cape Town, Cap Town, South Africa
    OMICS . 2017
  4. ncbi SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins
    S C Borinstein
    Department of Anatomy, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
    Cell Signal 12:769-79. 2000
  5. doi Disruption of CNTNAP2 and additional structural genome changes in a boy with speech delay and autism spectrum disorder
    Martin Poot
    Department of Medical Genetics, University Medical Centre Utrecht, Mail stop KC 04 084 2, P O Box 85090, 3508, Utrecht, The Netherlands
    Neurogenetics 11:81-9. 2010
  6. pmc Up-regulation of hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) by specific interaction with K+ channel tetramerization domain-containing protein 3 (KCTD3)
    Xiaochun Cao-Ehlker
    Center for Integrated Protein Science CIPS M and Zentrum für Pharmaforschung, Department Pharmazie, Ludwig Maximilians Universitat Munchen, 81377 Munich, Germany
    J Biol Chem 288:7580-9. 2013

Scientific Experts

  • Martin Poot
  • Kamogelo Lebeko
  • Daniel Trujillano
  • Amal Alhashem
  • Majid Alfadhel
  • Nouriya Al-Sannaa
  • Anas M Alazami
  • Xiaochun Cao-Ehlker
  • Ahmed Al-Rumayyan
  • Rolf Schroder
  • Martin Werber
  • Collet Dandara
  • Noluthando Manyisa
  • Oliver Brandau
  • Julia Köster
  • Nahid Nahavandi
  • Arndt Rolfs
  • Aida M Bertoli-Avella
  • Emile R Chimusa
  • Omid Paknia
  • Anett Marais
  • Wafaa Eyaid
  • Ambroise Wonkam
  • Mohammed Al-Balwi
  • Ali Alothaim
  • Jose Maria Garcia-Aznar
  • Krishna Kumar Kandaswamy
  • Caterina Baldi
  • Shivendra Kishore
  • Muhammad Talal Al Rifai
  • Maria Calvo Del Castillo
  • Rami Abou Jamra
  • Nicola Mulder
  • Waleed Al-Twaijri
  • Maximilian Er Weiss
  • Karen Wessel
  • Firdous Abdulwahab
  • Yong Xiong
  • Saeed Al Tala
  • Fatema Alzahrani
  • Zuhair N Al-Hassnan
  • Henry C Nguyen
  • Saad A Alshahwan
  • Abdulrahman A Aldeeri
  • Banan Al-Younes
  • Amal Y Kentab
  • Nisha Patel
  • Muneera Alshammari
  • Dorota M Monies
  • Jawahir Y Mohamed
  • Nouran Adly
  • Fowzan S Alkuraya
  • Mohammed A Aldahmesh
  • Xiaofei Jia
  • Hadia Hijazi
  • Heba Y El Khashab
  • Mohammed Zain Seidahmed
  • Sameera Sogaty
  • Mohammad Alsogheer
  • Fahad A Bashiri
  • Mohamed Abouelhoda
  • Ewa A Naim
  • Hanan E Shamseldin
  • Fatema AlQallaf
  • Shamsa Anazi
  • Zainab Babay
  • Rakad Hammami
  • Mohammed Al-Owain
  • Adnan A Alhadid
  • Brian F Meyer
  • Wesam Kurdi
  • Ghada M H Abdel-Salam
  • Mohammed S Al-Dosari
  • Mais Hashem
  • Ranad Shaheen
  • Hesham Aldhalaan
  • Fuad Al Mutairi
  • Rasha F Aljelaify
  • Niema Ibrahim
  • Saeed Bohlega
  • Namik Kaya
  • Eissa Faqeih
  • Mustafa A Salih
  • Maha Tulbah
  • Mohamad Hani Temsah
  • Martin Biel
  • Verena Hammelmann
  • Christian Gruner
  • Xiangang Zong
  • Christian Wahl-Schott

Detail Information

Publications6

  1. doi Accelerating novel candidate gene discovery in neurogenetic disorders via whole-exome sequencing of prescreened multiplex consanguineous families
    Anas M Alazami
    Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia
    Cell Rep 10:148-61. 2015
    ..DMBX1, CLHC1, C12orf4, WDR93, ST7, MATN4, SEC24D, PCDHB4, PTPN23, TAF6, TBCK, FAM177A1, KIAA1109, MTSS1L, XIRP1, KCTD3, CHAF1B, ARV1, ISCA2, PTRH2, GEMIN4, MYOCD, PDPR, DPH1, NUP107, TMEM92, EPB41L4A, and FAM120AOS)...
  2. pmc Clinical exome sequencing: results from 2819 samples reflecting 1000 families
    Daniel Trujillano
    Centogene AG, Rostock, Germany
    Eur J Hum Genet 25:176-182. 2017
    ..enabled timely diagnosing of genetic diseases, validation of causality of specific genetic disorders of PTPN23, KCTD3, SCN3A, PPOX, FRMPD4, and SCN1B, and setting dual diagnoses by detecting two causative variants in distinct genes ..
  3. doi A Genomic and Protein-Protein Interaction Analyses of Nonsyndromic Hearing Impairment in Cameroon Using Targeted Genomic Enrichment and Massively Parallel Sequencing
    Kamogelo Lebeko
    1 Division of Human Genetics, Department of Pathology, Faculty of Health Sciences University of Cape Town, Cap Town, South Africa
    OMICS . 2017
    ..Furthermore, 10 genes (MYO7A, MYO6, KCTD3, NUMA1, MYH9, KCNQ1, UBC, DIAPH1, PSMC2, and RDX) were identified as significant hubs within the subnetworks...
  4. ncbi SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins
    S C Borinstein
    Department of Anatomy, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
    Cell Signal 12:769-79. 2000
    ..Evidence that SETA binds to the CD2 protein, the proto-oncogene c-Cbl, and the signal transduction molecule Grb2, and can dimerize via its C-terminal coiled coil (CC) domain is also presented...
  5. doi Disruption of CNTNAP2 and additional structural genome changes in a boy with speech delay and autism spectrum disorder
    Martin Poot
    Department of Medical Genetics, University Medical Centre Utrecht, Mail stop KC 04 084 2, P O Box 85090, 3508, Utrecht, The Netherlands
    Neurogenetics 11:81-9. 2010
    ..Second, we found another de novo deletion on chromosome 1q41, containing 15 annotated genes, including KCTD3 and USH2A...
  6. pmc Up-regulation of hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) by specific interaction with K+ channel tetramerization domain-containing protein 3 (KCTD3)
    Xiaochun Cao-Ehlker
    Center for Integrated Protein Science CIPS M and Zentrum für Pharmaforschung, Department Pharmazie, Ludwig Maximilians Universitat Munchen, 81377 Munich, Germany
    J Biol Chem 288:7580-9. 2013
    ..Here, we identify KCTD3, a so far uncharacterized member of the potassium channel tetramerization-domain containing (KCTD) protein family ..