KCNN3

Summary

Gene Symbol: KCNN3
Description: potassium calcium-activated channel subfamily N member 3
Alias: KCa2.3, SK3, SKCA3, hSK3, small conductance calcium-activated potassium channel protein 3, SKCa 3, potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3, potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3, small conductance calcium-activated potassium channel 3
Species: human

Top Publications

  1. pmc HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation
    Q H Liu
    Department of Animal Biology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 97:4832-7. 2000
  2. pmc Role of S3 and S4 transmembrane domain charged amino acids in channel biogenesis and gating of KCa2.3 and KCa3.1
    Yajuan Gao
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Biol Chem 283:9049-59. 2008
  3. ncbi Small-conductance, calcium-activated potassium channels from mammalian brain
    M Kohler
    Vollum Institute, L 474, Oregon Health Sciences University, 3181 Southwest Sam Jackson Road, Portland, OR 97201, USA J Maylie, Department of Obstetrics and Gyne
    Science 273:1709-14. 1996
  4. ncbi Isolation of a novel potassium channel gene hSKCa3 containing a polymorphic CAG repeat: a candidate for schizophrenia and bipolar disorder?
    K G Chandy
    Department of Physiology and Biophysics, University of California, Irvine 92697, USA
    Mol Psychiatry 3:32-7. 1998
  5. ncbi Quantitative expression analysis of the small conductance calcium-activated potassium channels, SK1, SK2 and SK3, in human brain
    R Rimini
    Molecular Biology and Biochemistry Unit, Biology Department, GlaxoWellcome Medicines Research Centre, Via A Fleming 4, 37135 Verona, Italy
    Brain Res Mol Brain Res 85:218-20. 2000
  6. ncbi Nuclear localization and dominant-negative suppression by a mutant SKCa3 N-terminal channel fragment identified in a patient with schizophrenia
    M J Miller
    Department of Physiology and Biophysics, Division of Human Genetics, University of California Irvine, Irvine, California 92697 4561, USA
    J Biol Chem 276:27753-6. 2001
  7. ncbi The SK3 subunit of small conductance Ca2+-activated K+ channels interacts with both SK1 and SK2 subunits in a heterologous expression system
    Alan S Monaghan
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    J Biol Chem 279:1003-9. 2004
  8. pmc Association analysis of a highly polymorphic CAG Repeat in the human potassium channel gene KCNN3 and migraine susceptibility
    Robert Curtain
    Genomics Research Centre, School of Health Science, Griffith University, Gold Coast, Queensland, Australia
    BMC Med Genet 6:32. 2005
  9. ncbi International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels
    Aguan D Wei
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Pharmacol Rev 57:463-72. 2005
  10. ncbi hKCa3/KCNN3 potassium channel gene: association of longer CAG repeats with schizophrenia in Israeli Ashkenazi Jews, expression in human tissues and localization to chromosome 1q21
    V Dror
    Human Genetics Department, Sackler Faculty of Medicine, Tel Aviv, Israel
    Mol Psychiatry 4:254-60. 1999

Research Grants

  1. MELISSA HERNANDEZ KELLEY; Fiscal Year: 2014
  2. Satellite Glial Cells
    Luc Jasmin; Fiscal Year: 2013
  3. Assembly and Trafficking of IK1 and SK3 in Endothelia
    Daniel C Devor; Fiscal Year: 2012
  4. Determining the Role of the Potassium Channel, KCNN3, in Atrial Fibrillation
    PATRICK THOMAS ELLINOR; Fiscal Year: 2013
  5. Coronary Artery Regulation by Small Conduction Ca2+-activated K+ Channels
    MARK STEPHEN TAYLOR; Fiscal Year: 2011
  6. Memory modulation by SK channels
    ROBERT WILLIAM STACKMAN; Fiscal Year: 2013
  7. Nipavan Chiamvimonvat; Fiscal Year: 2016
  8. Endothelial SK3 Channel Modulation of EDHF is Estrogen Regulated
    Mike T Lin; Fiscal Year: 2011
  9. Mike T Lin; Fiscal Year: 2014
  10. Sathish Kumar; Fiscal Year: 2016

Detail Information

Publications208 found, 100 shown here

  1. pmc HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation
    Q H Liu
    Department of Animal Biology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 97:4832-7. 2000
    ..Intracellular signaling responses of macrophages to HIV-1 may modulate postentry steps of infection and cell functions apart from infection...
  2. pmc Role of S3 and S4 transmembrane domain charged amino acids in channel biogenesis and gating of KCa2.3 and KCa3.1
    Yajuan Gao
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Biol Chem 283:9049-59. 2008
    ..Furthermore, these improperly folded K(+) channels are translocated out of the endoplasmic reticulum in a Derlin-1- and p97-dependent fashion, poly-ubiquitylated, and targeted for proteasomal degradation...
  3. ncbi Small-conductance, calcium-activated potassium channels from mammalian brain
    M Kohler
    Vollum Institute, L 474, Oregon Health Sciences University, 3181 Southwest Sam Jackson Road, Portland, OR 97201, USA J Maylie, Department of Obstetrics and Gyne
    Science 273:1709-14. 1996
    ....
  4. ncbi Isolation of a novel potassium channel gene hSKCa3 containing a polymorphic CAG repeat: a candidate for schizophrenia and bipolar disorder?
    K G Chandy
    Department of Physiology and Biophysics, University of California, Irvine 92697, USA
    Mol Psychiatry 3:32-7. 1998
    ..These polyglutamine repeats may modulate hSKCa3 channel function and neuronal excitability, and thereby increase disease risk when combined with other genetic and environmental effects...
  5. ncbi Quantitative expression analysis of the small conductance calcium-activated potassium channels, SK1, SK2 and SK3, in human brain
    R Rimini
    Molecular Biology and Biochemistry Unit, Biology Department, GlaxoWellcome Medicines Research Centre, Via A Fleming 4, 37135 Verona, Italy
    Brain Res Mol Brain Res 85:218-20. 2000
    ..In the present study, we report the first quantitative analysis of SK1, SK2 and SK3 expression in human brain using TaqMan RT-PCR on a range of human brain and peripheral tissue samples...
  6. ncbi Nuclear localization and dominant-negative suppression by a mutant SKCa3 N-terminal channel fragment identified in a patient with schizophrenia
    M J Miller
    Department of Physiology and Biophysics, Division of Human Genetics, University of California Irvine, Irvine, California 92697 4561, USA
    J Biol Chem 276:27753-6. 2001
    The small conductance calcium-activated K+ channel gene SKCa3/KCNN3 maps to 1q21, a region strongly linked to schizophrenia...
  7. ncbi The SK3 subunit of small conductance Ca2+-activated K+ channels interacts with both SK1 and SK2 subunits in a heterologous expression system
    Alan S Monaghan
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    J Biol Chem 279:1003-9. 2004
    The aim of this study was to determine whether functional heteromeric channels can be formed by co-assembly of rat SK3 (rSK3) potassium channel subunits with either SK1 or SK2 subunits...
  8. pmc Association analysis of a highly polymorphic CAG Repeat in the human potassium channel gene KCNN3 and migraine susceptibility
    Robert Curtain
    Genomics Research Centre, School of Health Science, Griffith University, Gold Coast, Queensland, Australia
    BMC Med Genet 6:32. 2005
    ..Mutations in various ion channel genes are responsible for a number of neurological disorders. KCNN3 is a neuronal small conductance calcium-activated potassium channel gene that contains two polyglutamine tracts, ..
  9. ncbi International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels
    Aguan D Wei
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Pharmacol Rev 57:463-72. 2005
  10. ncbi hKCa3/KCNN3 potassium channel gene: association of longer CAG repeats with schizophrenia in Israeli Ashkenazi Jews, expression in human tissues and localization to chromosome 1q21
    V Dror
    Human Genetics Department, Sackler Faculty of Medicine, Tel Aviv, Israel
    Mol Psychiatry 4:254-60. 1999
    We demonstrate a significant association between longer CAG repeats in the hKCa3/KCNN3 calcium-activated potassium channel gene and schizophrenia in Israeli Ashkenazi Jews...
  11. ncbi The human small conductance calcium-regulated potassium channel gene (hSKCa3) contains two CAG repeats in exon 1, is on chromosome 1q21.3, and shows a possible association with schizophrenia
    O Wittekindt
    Institut für Humangenetik and Anthropologie, Universitat Freiburg, Germany
    Neurogenetics 1:259-65. 1998
    ..Both CAG repeats have been typed in 86 bipolar I disorder patients, and no significant difference in allele distribution was observed between our bipolar disorder patients and controls...
  12. ncbi Association between anorexia nervosa and the hsKCa3 gene: a family-based and case control study
    M Koronyo-Hamaoui
    The Danek Gertner Institute of Human Genetics, Sheba Medical Center, Tel Hashomer, Israel
    Mol Psychiatry 7:82-5. 2002
    ..005). Our study suggests that the longer repeat alleles of the hSKCa3 gene may contribute to the genetic susceptibility to AN...
  13. ncbi An association of CAG repeats at the KCNN3 locus with symptom dimensions of schizophrenia
    Michael Ritsner
    Sha ar Menashe Mental Health Center, Mobile Post Hefer 38814, Hadera, Israel
    Biol Psychiatry 51:788-94. 2002
    In 1999 Cardno et al reported that long CAG repeats in the calcium-activated potassium channel gene hSKCa3/KCNN3 are associated with higher negative symptom dimension scores in schizophrenia patients...
  14. ncbi CAG-repeat length in exon 1 of KCNN3 does not influence risk for schizophrenia or bipolar disorder: a meta-analysis of association studies
    Stephen J Glatt
    Department of Psychiatry, Harvard Medical School at Massachusetts Mental Health Center, Boston, Massachusetts 02115, USA
    Am J Med Genet B Neuropsychiatr Genet 121:14-20. 2003
    ..The gene KCNN3, which codes for a small/intermediate conductance, calcium-regulated potassium channel, contains a highly ..
  15. pmc Recycling of the Ca2+-activated K+ channel, KCa2.3, is dependent upon RME-1, Rab35/EPI64C, and an N-terminal domain
    Yajuan Gao
    Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 285:17938-53. 2010
    ..3 with Rab35 but significantly decreased the association with RME-1. These represent the first studies elucidating the mechanisms by which KCa2.3 is maintained at the plasma membrane...
  16. ncbi Calcium-activated potassium channel and connexin expression in small mesenteric arteries from eNOS-deficient (eNOS-/-) and eNOS-expressing (eNOS+/+) mice
    Lisa Ceroni
    Smooth Muscle Research Group, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1
    Eur J Pharmacol 560:193-200. 2007
    ..points between 1st and 2nd and 2nd and 3rd order vessels, were analysed for the expression of mRNA for SK1, SK2, SK3, IK and large conductance calcium-activated potassium channels (BK) and comparable studies were performed for ..
  17. pmc An amino acid outside the pore region influences apamin sensitivity in small conductance Ca2+-activated K+ channels
    Andreas Nolting
    Laboratory of Molecular Pharmacology, Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    J Biol Chem 282:3478-86. 2007
    ..The bee venom toxin apamin inhibits exclusively the three cloned SK channel subtypes (SK1, SK2, and SK3) with different affinity, highest for SK2, lowest for SK1, and intermediate for SK3 channels...
  18. ncbi The role of small-conductance Ca2+-activated K+ channels in the modulation of 4-aminopyridine-induced burst firing in rat cerebellar Purkinje cells
    Hashem Haghdoost Yazdi
    Neuroscience Research Center and Department of Physiology, Shaheed Beheshti Medical Sciences University, Tehran, Iran
    Brain Res 1156:59-66. 2007
    ..In the mammalian brain, 3 subunits (SK1-SK3) are expressed with different distributions...
  19. ncbi Characterization of the outer pore region of the apamin-sensitive Ca2+-activated K+ channel rSK2
    Heike Jäger
    Department of Applied Physiology, University of Ulm, Albert Einstein Allee 11, 89081 Ulm, Germany
    Toxicon 43:951-60. 2004
    ..residues in the outer pore of the SK channels we introduced point mutations that render SK2 K+ channel SK1 and SK3 like...
  20. ncbi Domain analysis of the calcium-activated potassium channel SK1 from rat brain. Functional expression and toxin sensitivity
    Dieter D'Hoedt
    Wellcome Laboratory for Molecular Pharmacology, Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, U K
    J Biol Chem 279:12088-92. 2004
    Two small conductance, calcium-activated potassium channels (SK channels), SK2 and SK3, have been shown to contribute to the afterhyperpolarization (AHP) and to shape the firing behavior in neurons for example in the hippocampal ..
  21. ncbi Modulators of small- and intermediate-conductance calcium-activated potassium channels and their therapeutic indications
    Heike Wulff
    Department of Medical Pharmacology and Toxicology, University of California, Davis, CA 95616, USA
    Curr Med Chem 14:1437-57. 2007
    ..1-KCa2.3 (a.k.a. SK1-SK3) and the intermediate-conductance channel KCa3.1 (a.k.a. IKCa1)...
  22. doi Obesity up-regulates intermediate conductance calcium-activated potassium channels and myoendothelial gap junctions to maintain endothelial vasodilator function
    Preet S Chadha
    Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, NSW, 2052, Australia
    J Pharmacol Exp Ther 335:284-93. 2010
    ..apamin had no effect on ACh-mediated dilation in either control or obese rat vessels, consistent with unaltered SK3 expression...
  23. pmc Identification and characterization of Ca2+-activated K+ channels in granulosa cells of the human ovary
    Matthias H Traut
    Institute for Cell Biology, University of Munich, Munich, Germany
    Reprod Biol Endocrinol 7:28. 2009
    ..g. acetylcholine) via raised intracellular Ca2+ levels. In this study, we aimed at characterizing 1. expression and functions of K(Ca) channels (including BK(Ca) beta-subunits), and 2. biophysical properties of BK(Ca) channels...
  24. pmc Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure
    Ananthakrishnan Sankaranarayanan
    Department of Pharmacology, University of California, Davis, California 95616, USA
    Mol Pharmacol 75:281-95. 2009
    ..The blood pressure-lowering effect of SKA-31 suggests KCa3.1 channel activation as a new therapeutic principle for the treatment of hypertension...
  25. ncbi Presynaptic localization of the small conductance calcium-activated potassium channel SK3 at the neuromuscular junction
    R Roncarati
    Department of Medicine and Public Health, Section of Pharmacology, University of Verona, 37134, Verona, Italy
    Neuroscience 104:253-62. 2001
    ..To date, three channel subunits (SK1-3) have been cloned from mammalian brain. Since SK3 only has been shown to be expressed in muscles upon denervation, this channel may be involved in hyperexcitability ..
  26. ncbi Novel 384-well population patch clamp electrophysiology assays for Ca2+-activated K+ channels
    Victoria H John
    Department of Assay Development, Discovery Research Biology, GlaxoSmithKline Research and Development, Gunnels Wood Road, Stevenage, Hertfordshire, SG7 5NJ, United Kingdom
    J Biomol Screen 12:50-60. 2007
    Planar array electrophysiology techniques were applied to assays for modulators of recombinant hIK and hSK3 Ca2+-activated K+ channels...
  27. pmc Protein expression of small conductance calcium-activated potassium channels is altered in inferior colliculus neurons of the genetically epilepsy-prone rat
    PROSPER N'GOUEMO
    Department of Pediatrics, Bldg D, Room 285, Georgetown University Medical Center, 3900 Reservoir Rd, NW, Washington, DC 20057, USA
    Brain Res 1270:107-11. 2009
    ..The present report shows that the levels of protein expression of SK1 and SK3 subtypes of the small conductance Ca2+-activated K+ channels were significantly decreased, while SK2 channel ..
  28. ncbi Expression and distribution of a small-conductance calcium-activated potassium channel (SK3) protein in skeletal muscles from myotonic muscular dystrophy patients and congenital myotonic mice
    Takashi Kimura
    Department of Neurology, Osaka University Graduate School of Medicine, D 4, 2 2 Yamadaoka, Suita, 565 0871, Osaka, Japan
    Neurosci Lett 347:191-5. 2003
    The SK3 channel, a small-conductance calcium-activated potassium channel, is expressed in immature fibers of skeletal muscle and becomes down regulated after innervation...
  29. pmc Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+-activated K+ channels
    C Hougaard
    Neurosearch A S, Pederstrupvej 93, Ballerup, Denmark
    Br J Pharmacol 151:655-65. 2007
    Positive modulators of small conductance Ca(2+)-activated K(+) channels (SK1, SK2, and SK3) exert hyperpolarizing effects that influence the activity of excitable and non-excitable cells...
  30. doi Selective cognitive deficits and reduced hippocampal brain-derived neurotrophic factor mRNA expression in small-conductance calcium-activated K+ channel deficient mice
    J P R Jacobsen
    Department of In Vivo Pharmacology, Neurosearch A S, Ballerup, Denmark
    Neuroscience 163:73-81. 2009
    ..In this study, we used doxycycline-induced conditional SK3-deficient (T/T) mice to address the cognitive consequences of selective SK3 deficiency...
  31. doi Selective activation of the SK1 subtype of human small-conductance Ca2+-activated K+ channels by 4-(2-methoxyphenylcarbamoyloxymethyl)-piperidine-1-carboxylic acid tert-butyl ester (GW542573X) is dependent on serine 293 in the S5 segment
    Charlotte Hougaard
    Neurosearch A S, Pederstrupvej 93, DK 2750 Ballerup, Denmark
    Mol Pharmacol 76:569-78. 2009
    ..Whole-cell experiments showed that hSK2 and hSK3 channels were more than 10 times, and hIK channels even more than 100 times, less sensitive to GW542573X...
  32. ncbi Small conductance calcium-activated potassium channels of trout CNS: molecular structure, developmental expression, and partial biophysical characterization
    F Panofen
    Department of Animal Physiology, University of Osnabruck, Barbarastr 11, 49069 Osnabruck, Germany
    Brain Res Mol Brain Res 101:1-11. 2002
    ..small conductance calcium-activated potassium channels that exhibited amino acid similarity with mammalian SK2 and SK3, respectively, were PCR cloned from the CNS of trout and sequenced...
  33. ncbi 5-HT1A receptors modulate small-conductance Ca2+-activated K+ channels
    Morten Grunnet
    MFI, Panum Institute, Copenhagen University, Copenhagen, Denmark
    J Neurosci Res 78:845-54. 2004
    ..the activity of SK channels by coexpressing 5-HT1A receptors with different subtypes of SK channels (SK1, SK2, and SK3) in Xenopus laevis oocytes. SK channels were activated by intracellular injection of Cd2+...
  34. pmc Calcium-activated and voltage-gated potassium channels of the pancreatic islet impart distinct and complementary roles during secretagogue induced electrical responses
    David A Jacobson
    Deparment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232 0615, USA
    J Physiol 588:3525-37. 2010
    ..1 is ablated or inhibited and enhanced GSIS by 2.7-fold. Human islets also express SK3 channels and their β-cell AP frequency is significantly accelerated by 4.8-fold with apamin...
  35. doi Apamin increases 5-HT cell firing in raphe dorsalis and extracellular 5-HT levels in amygdala: a concomitant in vivo study in anesthetized rats
    F Crespi
    Biology Department Neurosciences CEDD GlaxoSmithKline, Medicines Research Centre, Verona, Italy
    Brain Res 1281:35-46. 2009
    The family of calcium-activated slow-potassium (SK) channels comprises 3 members, the SK1, SK2 and SK3 channels, all expressed in neurons, known to mediate the slow-afterhyperpolarization occurring after action potentials...
  36. ncbi Structure and complex transcription pattern of the mouse SK1 K(Ca) channel gene, KCNN1
    B E Shmukler
    Molecular Medicine Unit, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Biochim Biophys Acta 1518:36-46. 2001
    Small conductance calcium-gated K(+) channels (SK channels) are encoded by the three SK genes, SK1, SK2, and SK3. These channels likely contribute to slow synaptic afterhyperpolarizations of apamin-sensitive and apamin-insensitive types...
  37. doi The sigma agonist 1,3-di-o-tolyl-guanidine directly blocks SK channels in dopaminergic neurons and in cell lines
    Cedric Lamy
    Laboratory of Pharmacology, GIGA Neurosciences, University of Liege, B 4000 Sart Tilman Liège 1, Belgium
    Eur J Pharmacol 641:23-8. 2010
    ..This hypothesis was tested in HEK-293 cells which were transiently transfected with rSK2 or hSK3 subunits. DTG inhibited the current flowing through both subtypes with mean IC(50)s approximately 200 microM...
  38. ncbi Electrophysiological properties of human adipose tissue-derived stem cells
    Xiaowen Bai
    Department of Molecular Pathology, University of Texas, MD Anderson Cancer Center, Houston, Texas 77054, USA
    Am J Physiol Cell Physiol 293:C1539-50. 2007
    ..1, Kv2.1, Kv1.5, Kv7.3, Kv11.1, and hEAG1, possibly encoding I(KDR); MaxiK, KCNN3, and KCNN4 for I(KCa); Kv1.4, Kv4.1, Kv4.2, and Kv4.3 for I(to) and hNE-Na for I(Na.TTX)...
  39. ncbi Localization of Ca2+-activated K+ channel, SK3, in fibroblast-like cells forming gap junctions with smooth muscle cells in the mouse small intestine
    Akikazu Fujita
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, Osaka Prefecture University, Japan
    J Pharmacol Sci 92:35-42. 2003
    ..b>SK3-immunoreactivity (IR) was detected in both ileum and colon...
  40. ncbi Small-conductance Ca2+-activated K+ channel type 2 (SK2) modulates hippocampal learning, memory, and synaptic plasticity
    Rebecca S Hammond
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239 3089, USA
    J Neurosci 26:1844-53. 2006
    ..Studies of SK channel knock-out mice reveal that of the three apamin-sensitive SK channel subunits (SK1-SK3), only SK2 subunits are necessary for the apamin-sensitive currents in CA1 hippocampal neurons...
  41. ncbi Expression of Ca(2+)-activated K(+) channels, SK3, in the interstitial cells of Cajal in the gastrointestinal tract
    A Fujita
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Science, Osaka Prefecture University, Sakai, Osaka 599 8531, Japan
    Am J Physiol Cell Physiol 281:C1727-33. 2001
    ..RT-PCR analysis shows expression of SK3 and SK4 mRNA, but not SK1 or SK2 mRNA, in the rat intestine...
  42. pmc Characterization of an apamin-sensitive small-conductance Ca(2+)-activated K(+) channel in porcine coronary artery endothelium: relevance to EDHF
    M P Burnham
    School of Biological Sciences, University of Manchester, Manchester M13 9PT, UK
    Br J Pharmacol 135:1133-43. 2002
    ..7 +/- 0.03 pS inhibited by d-tubocurarine was observed infrequently. 4. Messenger RNA encoding the SK2 and SK3, but not the SK1, subunits of SK(Ca) was detected by RT - PCR in samples of endothelium...
  43. ncbi Regional differences in distribution and functional expression of small-conductance Ca2+-activated K+ channels in rat brain
    Claudia A Sailer
    Institute for Biochemical Pharmacology, University Innsbruck, A 6020 Innsbruck, Austria
    J Neurosci 22:9698-707. 2002
    ..Immunoprecipitation detected solely homotetrameric SK2 and SK3 channels in native tissue and their constitutive association with calmodulin...
  44. ncbi The antidepressant fluoxetine blocks the human small conductance calcium-activated potassium channels SK1, SK2 and SK3
    Georg C Terstappen
    GlaxoSmithKline, Medicines Research Centre, Via A Fleming 4, 37135 Verona, Italy
    Neurosci Lett 346:85-8. 2003
    ..half-maximal inhibitory concentrations (IC(50)) of 9 microM for hSK1, 7 microM for hSK2 and 20 microM for hSK3. The block of hSK3 channels was confirmed by whole cell patch-clamp recordings of the recombinant cells and human ..
  45. ncbi Small conductance Ca2+-activated K+ channels as targets of CNS drug development
    Thomas Blank
    Department of Molecular Neuroendocrinology, Max Planck Institute for Experimental Medicine, D 37075 Goettingen, Germany
    Curr Drug Targets CNS Neurol Disord 3:161-7. 2004
    ..older brain regions such as the thalamus, basal ganglia, cerebellum, and brainstem show high levels of SK3 gene expression...
  46. doi Synthesis and structure-activity relationship studies of 2-(N-substituted)-aminobenzimidazoles as potent negative gating modulators ofsmall conductance Ca2+-activated K+ channels
    Ulrik S Sørensen
    Neurosearch A S, Pederstrupvej 93, DK 2750 Ballerup, Denmark
    J Med Chem 51:7625-34. 2008
    ..The first described compound in this class is NS8593 (14), and the most potent analogue identified in this study is the racemic compound 39 (NS11757), which reversibly inhibits SK3-mediated currents with a K(d) value of 9 nM.
  47. pmc Platelet-derived growth factor receptor α-positive cells in the tunica muscularis of human colon
    Masaaki Kurahashi
    Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV 89557, USA
    J Cell Mol Med 16:1397-404. 2012
    ..Platelet-derived growth factor receptor α(+) cells express small conductance Ca(2+)-activated K(+) channels (SK3), which are likely to mediate purinergic neural regulation of colonic muscles...
  48. pmc Significant Association Between CAV1 Variant rs3807989 on 7p31 and Atrial Fibrillation in a Chinese Han Population
    Shanshan Chen
    Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, China S C, C W, X W, C X, M W, P W, X T, Q K W
    J Am Heart Assoc 4:. 2015
    ..We previously replicated the 4q25 locus (PITX2) and 16q22 locus (ZFHX3) in the Chinese population, but not the KCNN3 locus on 1q21...
  49. doi Central serous chorioretinopathy: Recent findings and new physiopathology hypothesis
    Alejandra Daruich
    Department of Ophthalmology, University of Lausanne, Jules Gonin Eye Hospital, Fondation Asile des Aveugles, Lausanne, Switzerland
    Prog Retin Eye Res 48:82-118. 2015
    ....
  50. ncbi Tamapin, a venom peptide from the Indian red scorpion (Mesobuthus tamulus) that targets small conductance Ca2+-activated K+ channels and afterhyperpolarization currents in central neurons
    Paola Pedarzani
    Department of Physiology, University College London, London WC1E 6BT, United Kingdom
    J Biol Chem 277:46101-9. 2002
    ..toxins, tamapin displayed a unique, remarkable selectivity for SK2 versus SK1 ( approximately 1750-fold) and SK3 ( approximately 70-fold) channels and is the most potent SK2 channel blocker characterized so far (IC(50) for SK2 ..
  51. ncbi Altered expression of small-conductance Ca2+-activated K+ (SK3) channels modulates arterial tone and blood pressure
    Mark S Taylor
    Department of Pharmacology, University of Vermont, 89 Beaumont Ave, Burlington, VT 05405, USA
    Circ Res 93:124-31. 2003
    ..Here, we used a transgenic mouse (SK3T/T) in which SK3 expression levels can be manipulated with dietary doxycycline (DOX) to test the hypothesis that the level of ..
  52. ncbi Flow-dependent increase of ICAM-1 on saphenous vein endothelium is sensitive to apamin
    Sabena Sultan
    Department of Vascular Surgery, Imperial College at Charing Cross, London, UK
    Am J Physiol Heart Circ Physiol 287:H22-8. 2004
    ..Ca(2+)-activated K(+) channel (selectively blocked by apamin) were expressed in HSVECs and vein endothelium (SK3>SK2)...
  53. ncbi Small and intermediate conductance Ca(2+)-activated K+ channels confer distinctive patterns of distribution in human tissues and differential cellular localisation in the colon and corpus cavernosum
    Mao Xiang Chen
    Gene Expression and Protein Biochemistry, GlaxoSmithKline R and D, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK
    Naunyn Schmiedebergs Arch Pharmacol 369:602-15. 2004
    ..family of small and intermediate conductance calcium-activated potassium channels contains four members, SK1, SK2, SK3 and IK1, and is important for the regulation of a variety of neuronal and non-neuronal functions...
  54. pmc Pharmacological properties and functional role of Kslow current in mouse pancreatic beta-cells: SK channels contribute to Kslow tail current and modulate insulin secretion
    Min Zhang
    Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University Medical Center, Richmond, VA 23264, USA
    J Gen Physiol 126:353-63. 2005
    ..rather than cardiac-like slow delayed rectifier channels since bath application of AZ to HEK 293 cells expressing SK3 cDNA reduced SK current...
  55. pmc Early electrical remodeling in rabbit pulmonary vein results from trafficking of intracellular SK2 channels to membrane sites
    Nazira Ozgen
    Center for Molecular Therapeutics, Department of Pharmacology, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Cardiovasc Res 75:758-69. 2007
    ..The present study investigates the ionic and molecular mechanisms whereby two apamin-sensitive SK(Ca) channels, SK2 and SK3, might contribute to the regional APD changes.
  56. pmc Inhibition of vascular calcium-gated chloride currents by blockers of KCa1.1, but not by modulators of KCa2.1 or KCa2.3 channels
    W R Sones
    Division of Basic Medical Sciences, St George s, University of London, London, UK
    Br J Pharmacol 158:521-31. 2009
    ..1 inhibited calcium-activated Cl(-) currents (I(ClCa)) and if the pharmacological overlap between K(Ca)1.1 and CaCCs extends to intermediate and small conductance, calcium-activated K(+) channels...
  57. doi Differential regulation of calcium-activated potassium channels by dynamic intracellular calcium signals
    Joanne E Millership
    Faculty of Life Sciences, University of Manchester, 2nd Floor Core Technology Facility, 46 Grafton Street, Manchester, M13 9NT, UK
    J Membr Biol 235:191-210. 2010
    ..Therefore, the aim of the present study was to examine the effect of dynamic changes in [Ca(2+)](i) on small (SK3), intermediate (hIK1), and large conductance (BK) channels...
  58. pmc Hypotonicity-induced TRPV4 function in renal collecting duct cells: modulation by progressive cross-talk with Ca2+-activated K+ channels
    Min Jin
    Dept of Integrative Biology and Pharmacology, The University of Texas Health Science Center, Houston, TX 77030, USA
    Cell Calcium 51:131-9. 2012
    ..of TRPV4, along with the CCD marker, aquaporin-2, and the Ca(2+)-activated K(+) channels, the small conductance SK3 (K(Ca)2.3) channel and large conductance BKα channel (K(Ca)1.1)...
  59. pmc TRPV4 and the regulation of vascular tone
    Jessica A Filosa
    Georgia Health Sciences University, Augusta, GA, USA
    J Cardiovasc Pharmacol 61:113-9. 2013
    ..3), and large conductance (K(Ca)1.1) calcium-activated potassium-selective channels; and the importance of caveolin-rich domains for these interactions to take place...
  60. pmc Expression of postsynaptic Ca2+-activated K+ (SK) channels at C-bouton synapses in mammalian lumbar -motoneurons
    Adam S Deardorff
    Department of Neuroscience, Cell Biology and Physiology, Wright State University, Boonshoft School of Medicine, Dayton, OH 45435, USA
    J Physiol 591:875-97. 2013
    ..labelling of rat, mouse and cat spinal cord, we reveal a differential and overlapping expression of SK2 and SK3 isoforms across specific types of α-MNs...
  61. pmc Ovariectomy-induced reductions in endothelial SK3 channel activity and endothelium-dependent vasorelaxation in murine mesenteric arteries
    Fui C Yap
    Department of Physiology, University of South Alabama, Mobile, Alabama, United States of America
    PLoS ONE 9:e104686. 2014
    Mesenteric artery endothelium expresses both small (SK3)- and intermediate (IK1)-conductance Ca(2+)-activated K(+) (KCa) channels whose activity modulates vascular tone via endothelium-dependent hyperpolarization (EDH)...
  62. pmc Plectasin, first animal toxin-like fungal defensin blocking potassium channels through recognizing channel pore region
    Fang Xiang
    State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China
    Toxins (Basel) 7:34-42. 2015
    ..Besides Kv1.3 channel, plectasin could less inhibit Kv1.1, Kv1.2, IKCa, SKCa3, hERG and KCNQ channels at the concentration of 1 μΜ...
  63. pmc KCNN Genes that Encode Small-Conductance Ca2+-Activated K+ Channels Influence Alcohol and Drug Addiction
    Audrey E Padula
    Department of Neuroscience, Medical University of South Carolina, Charleston, SC, USA
    Neuropsychopharmacology 40:1928-39. 2015
    ..Alcohol preference and dependence QTLs contain KCNN2 and KCNN3, and Kcnn3 transcript levels in the nucleus accumbens (NAc) of genetically diverse BXD strains of mice predicted ..
  64. doi KCNN3 SNP rs13376333 on Chromosome 1q21 Confers Increased Risk of Atrial Fibrillation
    Jia lu Yao
    Department of Cardiology, The First Affiliated Hospital of Soochow University
    Int Heart J 56:511-5. 2015
    To investigate the relationship between KCNN3 SNP (single-nucleotide polymorphism) rs13376333 and risk of atrial fibrillation (AF) and to provide evidence for prevention and treatment for AF...
  65. doi Endothelial Small- and Intermediate-Conductance K Channels and Endothelium-Dependent Hyperpolarization as Drug Targets in Cardiovascular Disease
    R Kohler
    Aragon Institute of Health Sciences and IIS Aragon, Zaragoza, Spain Aragon Agency for Research and Development ARAID, Zaragoza, Spain Electronic address
    Adv Pharmacol 77:65-104. 2016
    ..Finally, the authors summarize recent advances in the pharmacology of the channels and explore potential therapeutic utilities of novel channel modulators. ..
  66. pmc Histidine phosphorylation relieves copper inhibition in the mammalian potassium channel KCa3.1
    Shekhar Srivastava
    Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, United States
    elife 5:. 2016
    ..These findings reveal a novel regulatory mechanism for a mammalian potassium channel and for T-cell activation, and highlight a unique feature of histidine versus serine/threonine and tyrosine as a regulatory phosphorylation site. ..
  67. ncbi CAG repeats of CTG18.1 and KCNN3 in Korean patients with bipolar affective disorder
    D K Jin
    Department of Pediatrics, Sungkyunkwan University School of Medicine, 50 Ilwon Dong, Kangnam Ku, Seoul 135 710, South Korea
    J Affect Disord 66:19-24. 2001
    ..The purpose of this study was to investigate the association of excess longer allele of KCNN3 and CTG18.1 in the patients with BPAD.
  68. ncbi Dynamics of CAG repeat loci revealed by the analysis of their variability
    Aida M Andres
    Unitat de Biologia Evolutiva, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, Barcelona, Spain
    Hum Mutat 21:61-70. 2003
    ..in pathological expansion), the diversity in 10 different loci (SCA1, SCA2, SCA3, SCA6, SCA8, SCA12, DRPLA, HD, KCNN3, and NCOA3) was analyzed in four major human groups (Africans, Europeans, Indians, and East Asians)...
  69. pmc Enhanced neuronal excitability in the absence of neurodegeneration induces cerebellar ataxia
    Vikram G Shakkottai
    Department of Physiology and Biophysics, University of California Irvine, 92697, USA
    J Clin Invest 113:582-90. 2004
    ..regulators of firing frequency, were silenced in the CNS of Tg mice with the dominant-inhibitory construct SK3-1B-GFP...
  70. ncbi The distribution of small and intermediate conductance calcium-activated potassium channels in the rat sensory nervous system
    L C Mongan
    Department of Cell Physiology and Pharmacology, University of Leicester, PO Box 138, Leicester LE1 9HN, UK
    Neuroscience 131:161-75. 2005
    ..We show that SK1, SK2, SK3 and IK1 are all expressed in DRG and spinal cord...
  71. ncbi Ion channel functional candidate genes in multigenic neuropsychiatric disease
    J Jay Gargus
    Department of Physiology, Section of Human Genetics, University of California, Irvine, California 92697 4034, USA
    Biol Psychiatry 60:177-85. 2006
    ..b>KCNN3 is explored as a paradigm to consider.
  72. pmc Apical SK potassium channels and Ca2+-dependent anion secretion in endometrial epithelial cells
    Melissa L Palmer
    Department of Physiology, 495 Animal Science Veterinary Medicine Bldg, University of Minnesota, 1988 Fitch Ave, St Paul, MN 55108, USA
    J Physiol 586:717-26. 2008
    ..5 nm and 1.8 microm, respectively, consistent with data previously reported for SK3 channels in excitable cells and hepatocytes...
  73. doi Bis-tetrahydroisoquinoline derivatives: AG525E1, a new step in the search for non-quaternary non-peptidic small conductance Ca(2+)-activated K(+) channel blockers
    Amaury Graulich
    Drug Research Center, Laboratory of Medicinal Chemistry, University of Liege, Avenue de l Hopital, 1 B36, B 4000 Liege 1, Belgium
    Bioorg Med Chem Lett 18:3440-5. 2008
    ..AG525E1 equipotently blocks SK1, SK2 and SK3 currents in transfected cell lines. Because of its basic and lipophilic properties, it can reach central SK targets.
  74. pmc The Ca2+ activated SK3 channel is expressed in microglia in the rat striatum and contributes to microglia-mediated neurotoxicity in vitro
    Lyanne C Schlichter
    Genes and Development Division, Toronto Western Research Institute, University Health Network, Toronto, Ontario, M5T 2S8, Canada
    J Neuroinflammation 7:4. 2010
    Small-conductance Ca2+ activated K+ channels are expressed in the CNS, where KCNN2/SK2/KCa2.2 and KCNN3/SK3/KCa2.3 help shape the electrical activity of some neurons...
  75. ncbi [Diabetes mellitus reduces the expression of SK3 in rat cavernous tissues]
    Jin hai Zhu
    Department of Urology, the First Hospital of Nanjing Affiliated to Nanjing Medical University, Nanjing, Jiangsu 210006, China
    Zhonghua Nan Ke Xue 16:236-9. 2010
    b>SK3, one of the small conductance calcium-activated potassium channels, is the key substance of the endothelium-derived hyperpolarizing factor (EDHF) passway...
  76. doi Crucial importance of the endothelial K+ channel SK3 and connexin40 in arteriolar dilations during skeletal muscle contraction
    Malte Milkau
    Institut fur Physiologie, Universitat zu Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    FASEB J 24:3572-9. 2010
    ..In EDHF signaling, endothelial hyperpolarization mediated by the Ca(2+)-activated K(+) channels SK3 and IK1 is a key step and also initiates gap junction-dependent conducted dilations...
  77. pmc SK3 channel expression during pregnancy is regulated through estrogen and Sp factor-mediated transcriptional control of the KCNN3 gene
    Stephanie L Pierce
    Department of Molecular Physiology and Biophysics, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Physiol Endocrinol Metab 299:E640-6. 2010
    ..The promoter region of the SK3-encoding mouse KCNN3 gene contains two binding sites for specificity protein (Sp) transcription factors, two of which are expressed in ..
  78. doi No association between the KCNH1, KCNJ10 and KCNN3 genes and schizophrenia in the Han Chinese population
    Qi Shen
    Bio X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai, China
    Neurosci Lett 487:61-5. 2011
    ..In the present study, we chose three potassium channel genes, KCNH1, KCNJ10, KCNN3 to investigate the role of potassium channels in schizophrenia by genotyping 23 SNPs (9 in KCNH1, 5 in KCNJ10 and ..
  79. pmc Single-nucleotide polymorphisms in the KCNN3 gene associate with preterm birth
    Lori J Day
    1Department of Obstetrics and Gynecology, University of Iowa Carver College of Medicine, Iowa City, IA, USA
    Reprod Sci 18:286-95. 2011
    The objectives were to determine whether single-nucleotide polymorphisms (SNPs) in KCNN3 (encodes the small conductance calcium-activated potassium channel subfamily N, member 3), associate with preterm birth (PTB)...
  80. doi Synthesis and radioligand binding studies of bis-(8-isopropyl-isoquinolinium) derivatives as ligands for apamin-sensitive sites on cloned SK2 and SK3 channels
    Eduard Badarau
    Laboratory of Medicinal Chemistry and C I R M, University of Liege, 1 avenue de l hopital B36, B 4000 Liege 1, Belgium
    Bioorg Med Chem Lett 21:6756-9. 2011
    ..derivatives (2a-e) were synthesized and tested for their affinity for cloned SK2 and SK3 channels in comparison with their 6,7-dimethoxy analogues (4a-f)...
  81. doi Eag1, Eag2, and SK3 potassium channel expression in the rat hippocampus after global transient brain ischemia
    R M Weffort de Oliveira
    Department of Pharmacology, University of Maringa UEM, Maringa, Parana, Brazil
    J Neurosci Res 90:632-40. 2012
    ..1 and K(V) 10.2), and small-conductance calcium-activated SK3 (K(Ca) 2.3, Kcnn3) K(+) channels in the hippocampus in rats after transient global brain ischemia...
  82. pmc Crucial role of a shared extracellular loop in apamin sensitivity and maintenance of pore shape of small-conductance calcium-activated potassium (SK) channels
    Kate L Weatherall
    School of Physiology and Pharmacology, University of Bristol, Bristol BS8 1TD, United Kingdom
    Proc Natl Acad Sci U S A 108:18494-9. 2011
    ..apamin displays some selectivity between SK channel subtypes, with SK2 being the most sensitive, followed by SK3 and then SK1...
  83. doi Further studies on bis-charged tetraazacyclophanes as potent inhibitors of small conductance Ca(2+)-activated K+ channels
    Donglai Yang
    Department of Chemistry, University College London, Gower Street, London WC1E 6BT, UK
    Eur J Med Chem 63:907-23. 2013
    ..assayed for inhibition of the afterhyperpolarization (AHP) in rat sympathetic neurons, an action mediated by the SK3 subtype of the SKCa channel...
  84. doi DiGalactosyl-Glycero-Ether Lipid: synthetic approaches and evaluation as SK3 channel inhibitor
    Charlotte M Sevrain
    Universite de Brest, UEB, CEMCA, CNRS UMR 6521, SFR ScInBioS, 6 Avenue Le Gorgeu, 29238 Brest, France
    Org Biomol Chem 11:4479-87. 2013
    The recent discoveries of the involvement of SK3 channel in some cell motility mechanisms occurring in cancer disease have opened up the way to the synthesis of inhibitors that could reduce metastasis formation...
  85. doi Identification of submicroscopic genetic changes and precise breakpoint mapping in myelofibrosis using high resolution mate-pair sequencing
    Terra Lasho
    Mayo College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Am J Hematol 88:741-6. 2013
    ..3), we were able to map the precise translocation breakpoints, which involved KCNN3 and GUSBP2 in one case and HYDIN2 in another...
  86. doi Pivotal role of the lipid Raft SK3-Orai1 complex in human cancer cell migration and bone metastases
    Aurelie Chantome
    INSERM, UMR1069, France
    Cancer Res 73:4852-61. 2013
    The SK3 channel, a potassium channel, was recently shown to control cancer cell migration, a critical step in metastasis outgrowth. Here, we report that expression of the SK3 channel was markedly associated with bone metastasis...
  87. doi Overexpression of ShDHN, a dehydrin gene from Solanum habrochaites enhances tolerance to multiple abiotic stresses in tomato
    Hui Liu
    Key Laboratory of Horticultural Plant Biology, Ministry of Education, Huazhong Agricultural University, No 1, Shizishan Street, Hongshan District, Wuhan, Hubei 430070, China Key Laboratory of Biology and Genetic Resources of Rubber Tree, Ministry of Agriculture, Rubber Research Institute, Chinese Academy of Tropical Agricultural Sciences, Danzhou 571737, China
    Plant Sci 231:198-211. 2015
    Dehydrins (DHNs) play important roles in plant adaptation to abiotic stress. In this study, a cold-induced SK3-type DHN gene (ShDHN) isolated from wild tomato species Solanum habrochaites was characterized for its function in abiotic ..
  88. doi Involvement of Ca(2+)-Dependent Hyperpolarization in Sleep Duration in Mammals
    Fumiya Tatsuki
    Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Neuron 90:70-85. 2016
    ..Here we found that impaired Ca(2+)-dependent K(+) channels (Kcnn2 and Kcnn3), voltage-gated Ca(2+) channels (Cacna1g and Cacna1h), or Ca(2+)/calmodulin-dependent kinases (Camk2a and Camk2b) ..
  89. pmc Ion Fluxes through KCa2 (SK) and Cav1 (L-type) Channels Contribute to Chronoselectivity of Adenosine A1 Receptor-Mediated Actions in Spontaneously Beating Rat Atria
    Bruno Bragança
    Laboratório de Farmacologia e Neurobiologia Center for Drug Discovery and Innovative Medicines MedInUP, Instituto de Ciências Biomédicas Abel Salazar ICBAS, Universidade do Porto UP Porto, Portugal
    Front Pharmacol 7:45. 2016
    ..1/3.4 channels modulating atrial chronotropy, A1 receptors may additionally restrain KCa2/SK activation thereby compensating atrial inotropic depression by increasing the time available for Ca(2+) influx through Cav1 (L-type) channels. ..
  90. doi The SigmaR1 chaperone drives breast and colorectal cancer cell migration by tuning SK3-dependent Ca2+ homeostasis
    M Gueguinou
    Inserm University U1069 Nutrition, Croissance et Cancer, Tours, France
    Oncogene . 2017
    ..increase calcium influx by triggering the coupling between SK3, a Ca2+-activated K+ channel (KCNN3) and the voltage-independent calcium channel Orai1. We show that SigmaR1 physically binds SK3 in BC cells...
  91. ncbi The role of calcium-activated potassium channels in respiratory control
    John M Bissonnette
    Department of Obstetrics and Gynecology, Medical Research Building, Mail Code L 458, Room MRB 830, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97201 3098, USA
    Respir Physiol Neurobiol 131:145-53. 2002
    ..The repression of this small-conductance K(+)ca channel (SK3) as well as its overexpression affect baseline respiratory rhythm and the ventilatory response to hypoxia.
  92. ncbi SK channels are necessary but not sufficient for denervation-induced hyperexcitability
    David Jacobson
    Department of Molecular and Medical Genetics, Oregon Health and Sciences University, Portland, Oregon, USA
    Muscle Nerve 26:817-22. 2002
    Skeletal muscle hyperexcitability is characteristically associated with denervation. Expression of SK3, a small conductance Ca(2+)-activated K(+) channel (SK channel) in skeletal muscle is induced by denervation, and direct application ..
  93. ncbi Determinants contributing to estrogen-regulated expression of SK3
    David Jacobson
    Vollum Institute, Oregon Health and Sciences University, Portland, OR 97201, USA
    Biochem Biophys Res Commun 303:660-8. 2003
    ..A 33 bp sequence adjacent to the promoter was shown to act as an enhancer in L6 cells that express SK3 and estrogen receptor alpha (ER alpha)...
  94. pmc In vivo pharmacological manipulation of small conductance Ca(2+)-activated K(+) channels influences motor behavior, object memory and fear conditioning
    Kyle A Vick
    Interdisciplinary Program in Neuroscience, Florida Atlantic University, Boca Raton, FL 33431 0991, USA
    Neuropharmacology 58:650-9. 2010
    ..The compound CyPPA selectively activates SK2 and SK3 channels in a similar manner. To date there has been no report of the effects of SK channel activators on memory...
  95. pmc In vivo measurement of intrauterine pressure by telemetry: a new approach for studying parturition in mouse models
    Stephanie L Pierce
    Department of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Physiol Genomics 42:310-6. 2010
    ..of this technology in the mouse, in both wild-type (WT) mice and a mouse model of defective parturition (SK3 channel-overexpressing mice), after surgical implant of telemetry transmitters into the uterine horn...
  96. doi Polymorphism of CAG motif of SK3 gene is associated with acute oxaliplatin neurotoxicity
    Michele Basso
    Medical Oncology, Department of Internal Medicine, Catholic University of Sacred Heart, Largo Agostino Gemelli n 8, 00168 Rome, Italy
    Cancer Chemother Pharmacol 67:1179-87. 2011
    ..As the SK3 gene is characterized in Caucasians by a highly polymorphic CAG motif within the exon 1, we hypothesize that SK3 ..
  97. pmc Modulation of endothelial SK3 channel activity by Ca²+dependent caveolar trafficking
    Mike T Lin
    Vollum Institute, Oregon Health and Science University, Portland, Oregon, USA
    Am J Physiol Cell Physiol 303:C318-27. 2012
    Small- and intermediate-conductance Ca(2+)-activated K(+) channels (SK3/Kcnn3 and IK1/Kcnn4) are expressed in vascular endothelium...
  98. pmc Activation of KCNN3/SK3/K(Ca)2.3 channels attenuates enhanced calcium influx and inflammatory cytokine production in activated microglia
    Amalia M Dolga
    Institute of Pharmacology and Clinical Pharmacy, Philipps University of Marburg, 35032, Marburg, Germany
    Glia 60:2050-64. 2012
    ..Only inhibitory peptides targeting KCNN3/SK3/K(Ca)2.3 channels, but not KCNN2/SK2/K(Ca)2...
  99. doi KCa and Ca(2+) channels: the complex thought
    Maxime Gueguinou
    INSERM, UMR1069 Nutrition, Croissance et Cancer, Tours F 37032, France Université François Rabelais, Tours 37032, France
    Biochim Biophys Acta 1843:2322-33. 2014
    ..subfamilies: big conductance (BKCa), intermediate conductance (IKCa) and small conductance (SKCa; SK1, SK2 and SK3)...
  100. doi Somatodendritic ion channel expression in substantia nigra pars compacta dopaminergic neurons across postnatal development
    Martial A Dufour
    INSERM, UMR_S 1072, 13015, Marseille, France Aix Marseille Université, UNIS, 13015, Marseille, France
    J Neurosci Res 92:981-99. 2014
    ..3, Kv2.1, Kv3.2, Kv3.3), A-type (Kv4.3) and calcium-activated SK (SK1, SK2, SK3) potassium currents, IH (mainly HCN2, HCN4), and the L- (Cav1.2, Cav1.3) and T-type (mainly Cav3.1, Cav3...
  101. doi The small conductance calcium-activated potassium channel 3 (SK3) is a molecular target for Edelfosine to reduce the invasive potential of urothelial carcinoma cells
    Konrad Steinestel
    Gerhard Domagk Institute of Pathology, University of Munster, Domagkstrasse 17, 48149, Munster, Germany
    Tumour Biol 37:6275-83. 2016
    ..The small conductance calcium-activated potassium channel 3 (SK3) enhances tumor cell invasion in breast cancer and malignant melanoma...

Research Grants23

  1. MELISSA HERNANDEZ KELLEY; Fiscal Year: 2014
    ..Among the three SK channel genes (SK1, SK2 and SK3) SK2 is the most highly expressed...
  2. Satellite Glial Cells
    Luc Jasmin; Fiscal Year: 2013
    ..code for a neurotransmitter receptor (P2Y4), an enzyme (guanylyl cyclase), a calcium-activated potassium channel (SK3), and a component of the gap junction (connexin 43)...
  3. Assembly and Trafficking of IK1 and SK3 in Endothelia
    Daniel C Devor; Fiscal Year: 2012
    ..be manipulated for clinical benefit requires us to answer the following questions: How are the number of IK1 and SK3 channels maintained at the plasma membrane, is this regulated by vasoactive agonists, what is the route of ..
  4. Determining the Role of the Potassium Channel, KCNN3, in Atrial Fibrillation
    PATRICK THOMAS ELLINOR; Fiscal Year: 2013
    ..novel locus was identified on chr 1q21;the most significant SNP, rs13376333, is intronic to the potassium channel KCNN3. In a meta-analysis of the primary and replication cohorts, rs13376333 had an odds ratio of 1.52 (P=1.8x10-21)...
  5. Coronary Artery Regulation by Small Conduction Ca2+-activated K+ Channels
    MARK STEPHEN TAYLOR; Fiscal Year: 2011
    ..We have recently demonstrated that small conductance Ca2+-activated K+ channels, SK3, are fundamental controllers of endothelial function in peripheral arteries, promoting sustained dilation ..
  6. Memory modulation by SK channels
    ROBERT WILLIAM STACKMAN; Fiscal Year: 2013
    ..retrieval and extinction;B) the consequence of specific blockade of SK2 channels, or the specific activation of SK3 and SK2 channels on hippocampal and amygdala memory processes;C) the efficacy of SK channel blockers to rescue the ..
  7. Nipavan Chiamvimonvat; Fiscal Year: 2016
    ..We propose to directly test the hypothesis using null mutant models of SK1, SK2 and SK3 channels...
  8. Endothelial SK3 Channel Modulation of EDHF is Estrogen Regulated
    Mike T Lin; Fiscal Year: 2011
    ..Recent work demonstrates that SK3 (small-conductance Ca2+-activated K+, subtype 3) channels play a crucial role in EDHF-mediated vasorelaxation, ..
  9. Mike T Lin; Fiscal Year: 2014
    ..I will use an integrated repertoire of electrophysiology, vascular reactivity, biochemistry molecular biology, and electron microscopy. ..
  10. Sathish Kumar; Fiscal Year: 2016
    ..the mechanisms for impaired EDHF-mediated vasodilation by determining mRNA and protein levels of EDHF components SK3 and IK1 channels and connexins (CX37, CX40, and CX47), their subcellular localization, and functional activity ..
  11. SK CHANNELS IN HYPEREXCITABLE SKELETAL MUSCLE
    John Adelman; Fiscal Year: 2001
    ..We have cloned the apamin sensitive SK channels from skeletal muscle, SK3, and found that upon denervation or after differentiation of the muscle cell line, L6, the SK3 gene is expressed ..
  12. Sub-type specific roles of SK channels in regulating dopamine neuron activity
    JASON T DEIGNAN; Fiscal Year: 2010
    ..It is previously reported that DA neurons express only one subtype of SK channels- the SK3 channels, and that these channels regulate the timing and frequency of DA neuron activity pattern...
  13. Modulation of CA1 Neuronal Excitability by SK Channels.
    Aaron Gerlach; Fiscal Year: 2002
    ..Three distinct SK channel subunits, SK1, SK2 and SK3, have been cloned and all are expressed in CA1 neurons...
  14. SK Channel Openers as Therapeutics for Cerebellar Ataxia
    Heike Wulff; Fiscal Year: 2007
    ..in the DCN, were silenced in DCN neurons of Tg mice with a naturally occurring dominant-inhibitory SK isoform (SK3-1B) that suppresses the entire SK channel family...
  15. Small Molecule Kv1.3 Blockers as New Therapeutics for Multiple Sclerosis
    Heike Wulff; Fiscal Year: 2007
    ..Lay: In multiple sclerosis the immune system attacks proteins in the brain of afflicted patients. The aim of this study is to identify and test new drugs that can suppress the white blood cells that are invading the brain. ..
  16. Austin 5HT Candidate Gene Discovery with C Elegans
    J Jay Gargus; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  17. Altered Accumbens Signaling Following Ethanol Exposure
    FREDERIC WOODWARD HOPF; Fiscal Year: 2010
    ..Altered spike firing and dopamine signaling in the NAcb could significantly influence the behavioral contribution of the NAcb, and in this way facilitate the onset of relapse. ..
  18. Plasticity of Oxytocin Neurons During Lactation
    William Armstrong; Fiscal Year: 2005
    ..These studies are important for understanding how the central control of OT neurons adapts to the demands of increased hormone secretion during pregnancy and lactation. ..
  19. ELECTRICAL CONTROL OF GASTRODUODENAL MOTILITY
    KENTON SANDERS; Fiscal Year: 2003
    ..This information will be useful in designing rational therapies for patients that suffer from problems resulting from inappropriate gastric emptying. ..
  20. The Genetic Basis of Atrial Fibrillation
    Patrick Ellinor; Fiscal Year: 2007
    ..Fishman. [] PHS 39812590 (Rev. 05101) Page % Continuation Format Page o Number pages consecutively at the bottom throughout the application. Do not use suffixes such as 3a, 3b. ..
  21. Electrophysiological Correlates of Vasopressin Secretion
    William Armstrong; Fiscal Year: 2009
    ..RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page 1 Description, ..
  22. Beta-adrenergic relaxation of urinary bladder smooth muscle
    Georgi Petkov; Fiscal Year: 2008
    ..Establishing the exact molecular mechanisms of UBSM P-adrenergic relaxation will provide new potential therapeutic targets for treating urinary incontinence. ..
  23. Heart Rate Variability in Mecp2 Deficient Mice
    JOHN BISSONNETTE; Fiscal Year: 2005
    ..These studies will contribute to the understanding of depressed parasympathetic activity in Rett syndrome. ..