KCNK5

Summary

Gene Symbol: KCNK5
Description: potassium two pore domain channel subfamily K member 5
Alias: K2p5.1, KCNK5b, TASK-2, TASK2, potassium channel subfamily K member 5, K2P5.1 potassium channel, TWIK-related acid-sensitive K(+) channel 2, TWIK-related acid-sensitive K+ channel 2, acid-sensitive potassium channel protein TASK-2, potassium channel, subfamily K, member 1 (TASK-2), potassium channel, subfamily, member 5 (KCNK5), potassium channel, two pore domain subfamily K, member 5
Species: human

Top Publications

  1. doi Upregulation of K2P5.1 potassium channels in multiple sclerosis
    Stefan Bittner
    Department of Neurology, University of Wurzburg, Wurzburg, Munster, Germany
    Ann Neurol 68:58-69. 2010
  2. ncbi Amide local anesthetics potently inhibit the human tandem pore domain background K+ channel TASK-2 (KCNK5)
    Christoph H Kindler
    Attending Physician, Department of Anesthesia, University Clinics, Kantonsspital, CH 4031 Basel, Switzerland
    J Pharmacol Exp Ther 306:84-92. 2003
  3. ncbi Tandem-pore domain potassium channels are functionally expressed in retinal (Müller) glial cells
    S N Skatchkov
    CMBN, Department of Biochemistry, School of Medicine, Universidad Central del Caribe, Bayamon, Puerto Rico 00960 6032
    Glia 53:266-76. 2006
  4. pmc The effects of huperzine A and IDRA 21 on visual recognition memory in young macaques
    Ludise Malkova
    Department of Pharmacology and the Interdisciplinary Program in Neuroscience, Georgetown University Medical Center, 3900 Reservoir Rd NW, Washington, DC 20007, USA
    Neuropharmacology 60:1262-8. 2011
  5. ncbi Localization of the tandem pore domain K+ channel KCNK5 (TASK-2) in the rat central nervous system
    Anja Gabriel
    Department of Anesthesia and Operative Intensive Care Medicine, University of Koln, 50924, Koln, Germany
    Brain Res Mol Brain Res 98:153-63. 2002
  6. doi TASK-2 is expressed in proximal neurons in the rat retina
    Xiao Min Zhang
    Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China
    Neuroreport 20:946-50. 2009
  7. ncbi Mutation of KCNK5 or Kir3.2 potassium channels in mice does not change minimum alveolar anesthetic concentration
    Karin M Gerstin
    Department of Anesthesia and Perioperative Care, University of California, San Francisco 94110, USA
    Anesth Analg 96:1345-9, table of contents. 2003
  8. ncbi Decision making in pathological gambling: a comparison between pathological gamblers, alcohol dependents, persons with Tourette syndrome, and normal controls
    Anna E Goudriaan
    Amsterdam Institute for Addiction Research, Academic Medical Centre, University of Amsterdam, The Netherlands
    Brain Res Cogn Brain Res 23:137-51. 2005
  9. ncbi fMRI of parents of children with Asperger Syndrome: a pilot study
    Simon Baron-Cohen
    Department of Psychiatry, Autism Research Centre, University of Cambridge, Douglas House, 18b Trumpington Road, Cambridge CB2 2AH, UK
    Brain Cogn 61:122-30. 2006
  10. ncbi Protective effects of Nicotiflorin on reducing memory dysfunction, energy metabolism failure and oxidative stress in multi-infarct dementia model rats
    Jin ling Huang
    Department of Pharmacology, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
    Pharmacol Biochem Behav 86:741-8. 2007

Detail Information

Publications190 found, 100 shown here

  1. doi Upregulation of K2P5.1 potassium channels in multiple sclerosis
    Stefan Bittner
    Department of Neurology, University of Wurzburg, Wurzburg, Munster, Germany
    Ann Neurol 68:58-69. 2010
    Activation of T cells critically depends on potassium channels. We here characterize the impact of K(2P)5.1 (KCNK5; TASK2), a member of the 2-pore domain family of potassium channels, on T-cell function and demonstrate its putative ..
  2. ncbi Amide local anesthetics potently inhibit the human tandem pore domain background K+ channel TASK-2 (KCNK5)
    Christoph H Kindler
    Attending Physician, Department of Anesthesia, University Clinics, Kantonsspital, CH 4031 Basel, Switzerland
    J Pharmacol Exp Ther 306:84-92. 2003
    ..of local anesthetics on members of this ion channel family, we heterologously expressed the 2P K+ channels TASK-2 (KCNK5), TASK-1 (KCNK3), and chimeric TASK-1/TASK-2 channels in oocytes of Xenopus laevis...
  3. ncbi Tandem-pore domain potassium channels are functionally expressed in retinal (Müller) glial cells
    S N Skatchkov
    CMBN, Department of Biochemistry, School of Medicine, Universidad Central del Caribe, Bayamon, Puerto Rico 00960 6032
    Glia 53:266-76. 2006
    ....
  4. pmc The effects of huperzine A and IDRA 21 on visual recognition memory in young macaques
    Ludise Malkova
    Department of Pharmacology and the Interdisciplinary Program in Neuroscience, Georgetown University Medical Center, 3900 Reservoir Rd NW, Washington, DC 20007, USA
    Neuropharmacology 60:1262-8. 2011
    ..b>Task 2 included, in each of 24 trials, a list of six objects presented in succession...
  5. ncbi Localization of the tandem pore domain K+ channel KCNK5 (TASK-2) in the rat central nervous system
    Anja Gabriel
    Department of Anesthesia and Operative Intensive Care Medicine, University of Koln, 50924, Koln, Germany
    Brain Res Mol Brain Res 98:153-63. 2002
    ..The 2P K+ channel TASK-2 (also named KCNK5) is sensitive to changes in extracellular pH, inhibited by local anesthetics and activated by volatile anesthetics...
  6. doi TASK-2 is expressed in proximal neurons in the rat retina
    Xiao Min Zhang
    Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China
    Neuroreport 20:946-50. 2009
    ..In AII glycinergic amacrine cells, however, only faint punctuate staining, if any, was seen. In addition, ganglion cells were also intensely labeled by TASK-2...
  7. ncbi Mutation of KCNK5 or Kir3.2 potassium channels in mice does not change minimum alveolar anesthetic concentration
    Karin M Gerstin
    Department of Anesthesia and Perioperative Care, University of California, San Francisco 94110, USA
    Anesth Analg 96:1345-9, table of contents. 2003
    ..MAC) needed to prevent movement in response to a noxious stimulus in 50% of adult mice lacking functional KCNK5 potassium channel subunits and compared these results with those for heterozygous and wild-type mice...
  8. ncbi Decision making in pathological gambling: a comparison between pathological gamblers, alcohol dependents, persons with Tourette syndrome, and normal controls
    Anna E Goudriaan
    Amsterdam Institute for Addiction Research, Academic Medical Centre, University of Amsterdam, The Netherlands
    Brain Res Cogn Brain Res 23:137-51. 2005
    ..Deficits in decision making and feedback processing in PG should be addressed in treatment and incorporated more explicitly in theoretical models of PG...
  9. ncbi fMRI of parents of children with Asperger Syndrome: a pilot study
    Simon Baron-Cohen
    Department of Psychiatry, Autism Research Centre, University of Cambridge, Douglas House, 18b Trumpington Road, Cambridge CB2 2AH, UK
    Brain Cogn 61:122-30. 2006
    ..People with autism or Asperger Syndrome (AS) show altered patterns of brain activity during visual search and emotion recognition tasks. Autism and AS are genetic conditions and parents may show the 'broader autism phenotype.'..
  10. ncbi Protective effects of Nicotiflorin on reducing memory dysfunction, energy metabolism failure and oxidative stress in multi-infarct dementia model rats
    Jin ling Huang
    Department of Pharmacology, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
    Pharmacol Biochem Behav 86:741-8. 2007
    ..These results suggest that Nicotiflorin has protective effects on reducing memory dysfunction, energy metabolism failure and oxidative stress in multi-infarct dementia model rats...
  11. ncbi Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery
    A D Medhurst
    Neuroscience Research, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Essex CM19 5AW, Harlow, UK
    Brain Res Mol Brain Res 86:101-14. 2001
    ..Furthermore, identification of common areas of expression may help identify which channels, if any, associate to form heteromeric K+ channel complexes...
  12. doi Activation of the TASK-2 channel after cell swelling is dependent on tyrosine phosphorylation
    Signe Skyum Kirkegaard
    Section of Cell and Developmental Biology, Dept of Biology, The August Krogh Bldg, Univ of Copenhagen, 13, Universitetsparken, DK 2100, Copenhagen, Denmark
    Am J Physiol Cell Physiol 299:C844-53. 2010
    ..It is suggested that the cytokine receptor-coupled JAK/STAT pathway is upstream of the swelling-induced phosphorylation and activation of TASK-2 in EATC...
  13. doi Volume regulation of murine T lymphocytes relies on voltage-dependent and two-pore domain potassium channels
    Nicole Bobak
    University of Muenster, Department of neurology Inflammatory disorders of the nervous system and neurooncology, Domagkstr, 13, 48149 Muenster, Germany
    Biochim Biophys Acta 1808:2036-44. 2011
    ..This study explores a putative role of the newly identified K(2P) channels (TASK1, TASK2, TASK3 and TRESK) along with the voltage-gated potassium channel K(V)1...
  14. ncbi The stage-specific effect of alcohol on human information processing
    Tom A Schweizer
    Department of Psychology, University of Waterloo, Waterloo, ON, Canada
    Psychopharmacology (Berl) 178:52-7. 2005
    ..quick succession, performance on the second task is increasingly degraded as the temporal gap between task 1 and task 2 decreases...
  15. pmc Evaluation of BioCreAtIvE assessment of task 2
    Christian Blaschke
    Bioalma SL, Ronda de Poniente 4 2nd floor, Tres Cantos, E 28760, Madrid, Spain
    BMC Bioinformatics 6:S16. 2005
    ..In order to make text mining tools useable in real world scenarios, for instance to assist database curators during annotation of protein function, comparisons and evaluations of different approaches on full text articles are needed...
  16. pmc Enhanced muscle fatigue occurs in male but not female ASIC3-/- mice
    Lynn A Burnes
    Graduate Program in Physical Therapy and Rehabilitation Science, Pain Research Program, Neuroscience Graduate Program, University of Iowa, Iowa City, IA 52242, USA
    Am J Physiol Regul Integr Comp Physiol 294:R1347-55. 2008
    ..two exercise protocols to measure exercise-induced muscle fatigue: (fatigue task 1, three 1-h runs; fatigue task 2, three 30-min runs)...
  17. doi When underadditivity of factor effects in the Psychological Refractory Period paradigm implies a bottleneck: evidence from psycholinguistics
    Derek Besner
    University of Waterloo, Waterloo, Ontario, Canada
    Q J Exp Psychol (Hove) 62:2222-34. 2009
    ..If the effect of a factor manipulated in Task 2 decreases as the stimulus onset asynchrony (SOA) between tasks decreases (underadditivity), the normative ..
  18. ncbi Deficits in facial emotion perception in adults with recent traumatic brain injury
    Robin E A Green
    Toronto Rehabilitation Institute, 550 University Avenue Room 1004, Toronto, Ont, Canada M5G 2A2
    Neuropsychologia 42:133-41. 2004
    ..Journal of Neuroscience 20(7) (2000) 2683] that damage to white matter tracts should give rise to emotion perception deficits...
  19. ncbi Fast, but error-prone, responses during acute alcohol intoxication: effects of stimulus-response mapping complexity
    Tom A Schweizer
    Department of Psychology, University of Waterloo, Waterloo, Ontario, Canada
    Alcohol Clin Exp Res 28:643-9. 2004
    ..This study used a psychological refractory period paradigm to investigate the effect of alcohol on the central, cognitive stage of information processing when task complexity is manipulated by altering stimulus-response compatibility...
  20. ncbi Synergists activation pattern of the quadriceps muscle differs when performing sustained isometric contractions with different EMG biofeedback
    Nicolas Place
    INSERM ERM 207 Motricité Plasticité, Faculte des Sciences du Sport, Universite de Bourgogne, Dijon Cedex, France
    Exp Brain Res 174:595-603. 2006
    ....
  21. ncbi Biomechanical investigation of ambulatory training in patients with acetabular dysplasia
    Akira Kanai
    Department of Physical Therapy, Toyohashi SOZO University School of Rehabilitation, 20 1 Matsusita, Ushikawa cho, Toyohashi City, Aichi, Japan
    Gait Posture 28:52-7. 2008
    ..In exercise task 2, walking speed was changed in three stages from 60 steps/min (s-gait), 90 steps/min (n-gait), and 120 steps/min (f-..
  22. doi Evidence for automatic on-line adjustments of hand orientation during natural reaching movements to stationary targets
    N Gosselin-Kessiby
    Departement de Physiologie, Universite de Montreal, Montreal, Quebec, Canada
    J Neurophysiol 99:1653-71. 2008
    ..In letter-posting task 2, subjects first aligned their hand to the angle of the target and then reached to it with the instruction not to ..
  23. doi Evidence for a proprioception-based rapid on-line error correction mechanism for hand orientation during reaching movements in blind subjects
    Nadia Gosselin-Kessiby
    Departement de Physiologie, Universite de Montreal, Montreal, Quebec, Canada H3C 3J7
    J Neurosci 29:3485-96. 2009
    ..In letter-posting task 2, blind subjects first aligned their hand to the orientation of the target and then subsequently reached to the ..
  24. doi Global synchronization in the theta band during mental imagery of navigation in humans
    Yang Li
    System Emotional Science, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani 2630, Toyama ken, Toyama 930 0194, Japan
    Neurosci Res 65:44-52. 2009
    ..Theta oscillation appears to play an important role in large-scale synchronization to form the functional neuronal networks required for mental navigation...
  25. ncbi Brazilian Portuguese version of the Iowa Gambling Task: transcultural adaptation and discriminant validity
    Leandro Fernandes Malloy-Diniz
    Neuropsychology and Neurosciences Research Group, Universidade Fumec, Belo Horizonte, MG, Brazil
    Rev Bras Psiquiatr 30:144-8. 2008
    ..The aim of this work was to adapt the Iowa Gambling Task to Brazilian Portuguese, compare it with the original version and assess its validity...
  26. ncbi Neuroprotective effect of remacemide hydrochloride in a perforant pathway stimulation model of status epilepticus in the rat
    T Halonen
    A I Virtanen Institute for Molecular Sciences, University of Kuopio, Finland
    Epilepsy Res 34:251-69. 1999
    ..did remacemide or carbamazepine treatment alleviate spatial memory impairment determined in a Morris water-maze task 2 weeks after PP stimulation...
  27. ncbi Genetic covariance among measures of information processing speed, working memory, and IQ
    M Luciano
    Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
    Behav Genet 31:581-92. 2001
    ..26 in females, 0.13 in males; genotypic: 0.34). A significant part of the genetic variance (43%) in IQ was not related to either choice RT or delayed response performance, and may represent higher order cognitive processes...
  28. ncbi Effects of 7 Hz-modulated 450 MHz electromagnetic radiation on human performance in visual memory tasks
    J Lass
    Biomedical Engineering Centre, Tallinn Technical University, Ehitajate tee 5, 19086 Tallinn, Estonia
    Int J Radiat Biol 78:937-44. 2002
    ..The aim was to examine low-level 7 Hz-modulated 450 MHz radiation effects on human performance in visually presented neuropsychological tasks associated with attention and short-term memory...
  29. pmc Functional MRI of language in aphasia: a review of the literature and the methodological challenges
    Bruce Crosson
    Department of Veterans Affairs Rehabilitation Research and Development Brain Rehabilitation Research Center at the Malcom Randall VA Medical Center, Gainesville, Florida, USA
    Neuropsychol Rev 17:157-77. 2007
    ..While the promise of fMRI in the study of aphasia is great, there is much work to be done before this technique will be a useful clinical tool...
  30. doi The locus coeruleus involves in consolidation and memory retrieval, but not in acquisition of inhibitory avoidance learning task
    Behrooz Khakpour-Taleghani
    Cellular and Molecular Research Center and Department of Physiology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
    Behav Brain Res 189:257-62. 2008
    ..In conclusion, it seems that the nucleus locus coeruleus does not affect acquisition while it involves in the memory consolidation and retrieval of inhibitory avoidance learning task...
  31. doi Asymmetric activation of motor cortex controlling human anterior digastric muscles during speech and target-directed jaw movements
    Paul F Sowman
    Research Centre for Human Movement Control, Discipline of Physiology, School of Molecular and Biomedical Sciences, The University of Adelaide, Adelaide 5005, South Australia, Australia
    J Neurophysiol 102:159-66. 2009
    ..speaking a single word; 3) visually guided, nonspeech jaw movement that matched the jaw kinematics recorded during task 2; and 4) reciting a sentence...
  32. ncbi Effect of fixation tasks on multifocal visual evoked potentials
    Alessandra Martins
    Save Sight Institute, Department of Ophthalmology and Eye Health, University of Sydney, Sydney Eye Hospital, Sydney, New South Wales, Australia
    Clin Exp Ophthalmol 33:499-504. 2005
    ..Three different foveal fixation conditions were utilized involving varying levels of task complexity. A more complex visual fixation task has been known to suppress peripheral signals in subjective testing...
  33. ncbi Predictors of driving exposure and avoidance in a field study of older drivers from the state of Maryland
    David E Vance
    Department of Psychology, Center for Translational Research on Aging and Mobility, University of Alabama at Birmingham, 35294 2100, USA
    Accid Anal Prev 38:823-31. 2006
    ..A performance-based assessment, which included the Gross Impairment Screening battery and task 2 of the UFOV test, was completed by participants...
  34. pmc Assessment of cognitive function in the heterozygous reeler mouse
    Dilja D Krueger
    Department of Psychiatry, Division of Molecular Psychiatry, Yale University School of Medicine, Ribicoff Research Facilities, CMHC, 34 Park Street, New Haven, CT 06508, USA
    Psychopharmacology (Berl) 189:95-104. 2006
    ..However, the effect of reelin haploinsufficiency on one of the cardinal symptoms of schizophrenia, the impairment of prefrontal-cortex-dependent cognitive function, has yet to be determined...
  35. doi Effects of an acute alpha-lactalbumin manipulation on mood and food hedonics in high- and low-trait anxiety individuals
    Ellen Verschoor
    Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Br J Nutr 104:595-602. 2010
    ..On both the test days, participants completed a stress-inducing task 2 h after the lunch. Mood and appetite were assessed using visual analogue scales...
  36. pmc Selective block of the human 2-P domain potassium channel, TASK-3, and the native leak potassium current, IKSO, by zinc
    Catherine E Clarke
    Department of Biological Sciences, Imperial College London, Exhibition Road, London SW7 2AZ, UK
    J Physiol 560:51-62. 2004
    ..Therefore it is possible that inhibition of IK(SO) in cerebellar granule cells by synaptically released zinc may have important physiological consequences...
  37. ncbi The psychological refractory period: evidence for age differences in attentional time-sharing
    P A Allen
    Department of Psychology, Cleveland State University, Ohio 44115, USA
    Psychol Aging 13:218-29. 1998
    ..psychological refractory period (PRP) experiments in which the stimulus onset asynchrony (SOA) between Task 1 and Task 2 was 150 ms, 250 ms, 600 ms, and 1,100 ms for both younger and older adults. H...
  38. ncbi Virtual reality flexible cystoscopy: a validation study
    J Shah
    Academic Surgical Unit, Imperial College of Science, Technology and Medicine, St Mary s Hospital, London, UK
    BJU Int 90:828-32. 2002
    ..To validate a flexible cystoscopy simulator by determining if it could differentiate between expert and novice cystoscopists...
  39. ncbi Rhythmic and discrete elements in multi-joint coordination
    Dagmar Sternad
    Department of Kinesiology, The Pennsylvania State University, 266 Rec Hall, University Park, PA 16803, USA
    Brain Res 989:152-71. 2003
    ..It was this rhythmic activity that posed the direct constraints on the initiation of the discrete movement...
  40. pmc An evaluation of GO annotation retrieval for BioCreAtIvE and GOA
    Evelyn B Camon
    European Molecular Biology Laboratory, European Bionformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK
    BMC Bioinformatics 6:S17. 2005
    ..BioCreAtIvE task 2 was an experiment to test if automatically derived classification using information retrieval and extraction could ..
  41. ncbi The psychological refractory period in Parkinson's disease
    S Hsieh
    Department of Psychology, National Chung Cheng University, Taiwan, ROC
    Percept Mot Skills 91:893-902. 2000
    ..The stimulus onset asynchrony (SOA) between Task 1 and Task 2 was 50 msec., 150 msec., and 650 msec...
  42. ncbi Event-related potentials evoked by multi-feature conflict under different attentive conditions
    Yuping Wang
    Department of Neurology, Xuanwu Hospital, Capital University of Medical Sciences, Beijing 100053 PR China
    Exp Brain Res 148:451-7. 2003
    ..In task 1, subjects attended to the color of the stimuli and ignored the other attributes. In task 2, they were asked to attend to both color and global shape of stimuli and disregard the local shape...
  43. pmc Mining protein function from text using term-based support vector machines
    Simon B Rice
    Faculty of Life Sciences, University of Manchester, UK
    BMC Bioinformatics 6:S22. 2005
    ..We participated in Task 2, which addressed assigning Gene Ontology terms to human proteins and selecting relevant evidence from full-text ..
  44. pmc pH sensing in the two-pore domain K+ channel, TASK2
    Michael J Morton
    School of Biomedical Sciences, Medical and Dental Building, University of Leeds, Leeds LS2 9NQ, United Kingdom
    Proc Natl Acad Sci U S A 102:16102-6. 2005
    b>TASK2 is a member of the two-pore domain K(+) channel family that plays a role in acid-base homeostasis; TASK2 knockout animals have plasma electrolyte patterns typical of the human clinical condition of renal tubular acidosis...
  45. ncbi Effect of flat insoles with different Shore A values on posture stability in diabetic neuropathy
    J A Van Geffen
    Center for Rehabilitation, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Prosthet Orthot Int 31:228-35. 2007
    ..It was found that prescribing insoles with a low Shore A value (15 degrees), compared to insoles with a higher Shore A value (30 degrees) has no significant negative effect on posture stability in patients with a diabetic neuropathy...
  46. pmc Three-dimensional in vivo quantification of knee kinematics in cerebral palsy
    Frances T Sheehan
    Physical Disabilities Branch, National Institutes of Health, National Institute of Child Health and Human Development and the Clinical Center, National Institutes of Health, Bethesda, MD 20892 1604, USA
    Clin Orthop Relat Res 466:450-8. 2008
    ..Fast phase contrast MRI may allow differentiation of patellofemoral and tibiofemoral function in various functional subtypes of cerebral palsy, providing insights into its management...
  47. pmc Task completion time: Objective tool for assessment of technical skills in laparoscopic simulator for urology trainees
    Shashi K Mishra
    Department of Urology and Nephrology, Muljibhai Patel Society for Research in Nephrourology, Muljibhai Patel Urological Hospital, Nadiad 387 001, Gujarat, India
    Indian J Urol 24:35-8. 2008
    ..Laparoscopic surgical simulation is a valuable training tool for urology trainees...
  48. ncbi [Analysis of interference effects in simultaneous processing of 2 problems]
    T Schubert
    Institut fur Psychologie, Humboldt Universitat Berlin
    Z Exp Psychol 43:625-56. 1996
    ..A well known result is that reaction time on task 2 (Rt2) increases with decreasing overlap of the two tasks...
  49. ncbi Incidental memory of differently processed odors
    L Hvastja
    Dipartimento di Psicologia Università di Trieste
    Percept Mot Skills 85:235-44. 1997
    ..test had to evaluate the intensity of each odor (Task 1), to judge the similarity of each odor to mint (Task 2), or to score each odor for pleasantness and sourness (Task 3)...
  50. ncbi High resolution spatiotemporal analysis of the contingent negative variation in simple or complex motor tasks and a non-motor task
    R Q Cui
    Department of Clinical Neurology, University of Vienna, Wahringer Gurtel 18 20, A 1090, Vienna, Austria
    Clin Neurophysiol 111:1847-59. 2000
    ....
  51. ncbi Early-onset schizophrenia is associated with impaired adolescent development of attentional capacity using the identical pairs continuous performance test
    Emily Thaden
    The Zucker Hillside Hospital, Department of Psychiatry Research 75 59 263rd Street, Glen Oaks, NY 11004, USA
    Schizophr Res 81:157-66. 2006
    ....
  52. ncbi Parallel central processing between tasks: evidence from lateralized readiness potentials
    Mei Ching Lien
    Department of Psychology, Oregon State University, Corvallis, Oregon 97331 5303, USA
    Psychon Bull Rev 14:133-41. 2007
    ..readiness potentials (LRPs) and behavioral measures to determine whether response activation for Task 1 and Task 2 can occur in parallel...
  53. ncbi Up-regulated astroglial TWIK-related acid-sensitive K+ channel-1 (TASK-1) in the hippocampus of seizure-sensitive gerbils: a target of anti-epileptic drugs
    Duk Soo Kim
    Department of Anatomy, College of Medicine, Hallym University, Chunchon 200 702, South Korea
    Brain Res 1185:346-58. 2007
    ....
  54. pmc Myocontrol in aging
    Eric J Fimbel
    Fatronik Foundation Research Center, Laboratoire Cognition et Facteurs humains EA 497, Institut de Cognitique, Bordeaux, France
    PLoS ONE 2:e1219. 2007
    ..However, when individual performance was examined, some aged individuals were found to perform as well as the young participants, congruently with the literature on good aging...
  55. doi The nature of phoneme representation in spoken word recognition
    M Gareth Gaskell
    Department of Psychology, University of York, York, UK
    J Exp Psychol Gen 137:282-302. 2008
    ..paradigm in which participants made forced-choice color categorization (Task 1) and phoneme categorization (Task 2) decisions at varying stimulus onset asynchronies...
  56. pmc Frontal brain activation in young children during picture book reading with their mothers
    S Ohgi
    Graduate School of Rehabilitation and Health Sciences, Seirei Christopher University, Hamamatsu, Shizuoka, Japan
    Acta Paediatr 99:225-9. 2010
    ..This study was to measure changes in frontal brain activation in young children during picture book reading with their mothers...
  57. pmc Motor preparation is modulated by the resolution of the response timing information
    Anthony N Carlsen
    Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, 645 N Michigan Ave, Chicago, IL 60611, USA
    Brain Res 1322:38-49. 2010
    ....
  58. pmc The effects of everyday concurrent tasks on overground minimum toe clearance and gait parameters
    Brian W Schulz
    HSR and D RR and D Center of Excellence Maximizing Rehabilitation Outcomes, James A Haley VA Hospital, 8900 Grand Oak Circle, Tampa, FL 33637 1022, USA
    Gait Posture 32:18-22. 2010
    ..The relationships between MTC, gait parameters, and older age or fall risk should be explored further in at-risk subjects and circumstances to elucidate potential tripping mechanisms...
  59. doi Effect of unaccustomed eccentric exercise on proprioception of the knee in weight and non-weight bearing tasks
    Carolina Vila-Chã
    Centre for Sensory Motor Interaction SMI, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7, D 3, DK 9220, Aalborg, Denmark
    J Electromyogr Kinesiol 21:141-7. 2011
    ..In conclusion, eccentric exercise of the quadriceps impairs proprioception of the knee both immediately after and 24h post exercise, but only in non-weight bearing tasks...
  60. pmc Changes in reward contingency modulate the trial-to-trial variability of hippocampal place cells
    Andrew M Wikenheiser
    Graduate Program in Neuroscience, University of Minnesota, Minneapolis, Minnesota, USA
    J Neurophysiol 106:589-98. 2011
    ..These results suggest that changes in task demands can affect the firing statistics of hippocampal neurons, leading to changes in the properties of decoded neural representations...
  61. doi Osmotic tolerance and intracellular ion concentrations of bovine sperm are affected by cryopreservation
    A K Blässe
    Clinic for Cattle, University of Veterinary Medicine Hannover, Hannover, Germany
    Theriogenology 78:1312-20. 2012
    ..In conclusion, cryopreserved sperm exhibit reduced tolerance to hypotonic stress, a decreased intracellular pH, and increased intracellular potassium level...
  62. doi Effect of nitric oxide synthase inhibitor L-NAME on fear extinction in rats: a task-dependent effect
    Huaiqing Luo
    Department of Physiology, Changsha Medical University, Changsha 410219, Hunan, PR China
    Neurosci Lett 572:13-8. 2014
    ..In task 2, rats received fear conditioning in context A, extinction training in context B and extinction test in context A (..
  63. doi HIF-1α-mediated upregulation of TASK-2 K⁺ channels augments Ca²⁺ signaling in mouse B cells under hypoxia
    Dong Hoon Shin
    Department of Physiology, Seoul National University College of Medicine, Seoul 110 799, Republic of Korea Division of Natural Medical Sciences, College of Health Science, Chosun University, Gwangju 501 759, Republic of Korea
    J Immunol 193:4924-33. 2014
    ..This is functionally important in maintaining the negative membrane potential and providing electrical driving force to control Ca(2+) influx...
  64. doi Investigation of brain electrophysiological properties among heroin addicts: Quantitative EEG and event-related potentials
    Farid Motlagh
    Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur, Malaysia
    J Neurosci Res . 2016
    ..Task 1 provided auditory P300 and P600 in association with working memory. Task 2 provided auditory P300 as well as small and large deviant MMN event-related potential (ERPs)...
  65. doi Spatial and dynamical handwriting analysis in mild cognitive impairment
    Jacek Kawa
    Faculty of Biomedical Engineering, Silesian University of Technology, Roosevelta st 40, Zabrze, Poland Electronic address
    Comput Biol Med 82:21-28. 2017
    ..g. median height of the text block in task 2 being 22.3mm, IQR 12.9 in MCI and 20.2mm, IQR 8.7 in control group)...
  66. ncbi Can practice eliminate the psychological refractory period effect?
    M Van Selst
    Department of Psychology, San Jose State University, California 95192, USA
    J Exp Psychol Hum Percept Perform 25:1268-83. 1999
    ..Refractory Period (PRP) experiment, where Task 1 required a speeded vocal response to an auditory stimulus and Task 2 required a speeded manual response to a visual stimulus...
  67. ncbi High resolution DC-EEG mapping of the Bereitschaftspotential preceding simple or complex bimanual sequential finger movement
    R Q Cui
    Department of Clinical Neurology, University of Vienna and Ludwig Boltzmann Institute of Functional Brain Topography, Austria
    Exp Brain Res 134:49-57. 2000
    ..the Bereitschaftspotential (BP) preceding voluntary bimanual sequential simple (task 1) and complex movements (task 2) in supplementary/cingulate and primary motor areas (SCMA, MIs) using 64-channel direct current ..
  68. ncbi Selective influence of second target exposure duration and task-1 load effects in the attentional blink phenomenon
    P Jolicoeur
    Department of Psychology, University of Waterloo, ON, Canada
    Psychon Bull Rev 7:472-9. 2000
    ..b>Task2 was always to report as many letters as possible from T2...
  69. pmc Proximal renal tubular acidosis in TASK2 K+ channel-deficient mice reveals a mechanism for stabilizing bicarbonate transport
    Richard Warth
    Institute of Physiology, Universitatsstrasse 31, 93053 Regensburg, Germany
    Proc Natl Acad Sci U S A 101:8215-20. 2004
    The acid- and volume-sensitive TASK2 K+ channel is strongly expressed in renal proximal tubules and papillary collecting ducts...
  70. ncbi Resolving dual-task interference: an fMRI study
    Yuhong Jiang
    Department of Psychology, Harvard University, Cambridge, MA 02138, USA
    Neuroimage 22:748-54. 2004
    ..two tasks are presented within a short stimulus-onset-asynchrony (SOA), reaction time of each task, especially task 2, is dramatically delayed...
  71. ncbi Prediction of development of fatigue during a simulated ambulance work task from physical performance tests
    M Barnekow-Bergkvist
    Centre for Musculoskeletal Research, University of Gavle, Sweden
    Ergonomics 47:1238-50. 2004
    ..The high physical strain during carrying the loaded stretcher implies the importance of investigating whether improved performance, matching the occupational demands, could decrease the development of fatigue during strenuous tasks...
  72. pmc Pancreatic two P domain K+ channels TALK-1 and TALK-2 are activated by nitric oxide and reactive oxygen species
    F Duprat
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS UMR 6097, 660 route des Lucioles, Sophia Antipolis, 06560 Vabonne, France
    J Physiol 562:235-44. 2005
    ....
  73. ncbi Symbolic distance affects two processing loci in the number comparison task
    Chris Oriet
    Department of Psychology, University of Regina, 3737 Wascana Parkway, Regina, Saskatchewan, S4S 0A2, Canada
    Mem Cognit 33:913-26. 2005
    ..The results show that (1) numeric information in Task 2 can be retrieved in parallel with capacity-demanding processing in Task 1 but (2) comparing two quantities ..
  74. ncbi Characterization of potassium channels involved in volume regulation of human spermatozoa
    J P Barfield
    Institute of Reproductive Medicine, University of Munster, Munster, Germany
    Mol Hum Reprod 11:891-7. 2005
    ..4, Kv1.5 and Kv1.7, acid-sensitive channel TASK2 and the beta-subunit minK (IsK) in regulatory volume decrease (RVD)...
  75. ncbi Backward response-level crosstalk in the psychological refractory period paradigm
    Jeff Miller
    Department of Psychology, University of Otago, Dunedin, New Zealand
    J Exp Psychol Hum Percept Perform 32:149-65. 2006
    ..models of psychological refractory period (PRP) tasks suggest that a Task 1 response should be unaffected by the Task 2 response in the same trial, because selection of the former finishes before selection of the latter begins...
  76. ncbi Contributions of prefrontal cue-, delay-, and response-period activity to the decision process of saccade direction in a free-choice ODR task
    Kei Watanabe
    Department of Cognitive and Behavioral Sciences, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, Japan
    Neural Netw 19:1203-22. 2006
    ..The gradual increase of the directional selectivity in delay-period activity might correspond to neural correlates of the decision process of the saccade direction in the S-ODR task...
  77. ncbi Extracellular pH alkalinization by Cl-/HCO3- exchanger is crucial for TASK2 activation by hypotonic shock in proximal cell lines from mouse kidney
    S L'Hoste
    UMR Centre National de la Recherche Scientifique 6548, Universite de Nice Sophia Antipolis, 06108 Nice Cedex 2, France
    Am J Physiol Renal Physiol 292:F628-38. 2007
    We have previously shown that K(+)-selective TASK2 channels and swelling-activated Cl(-) currents are involved in a regulatory volume decrease (RVD; Barriere H, Belfodil R, Rubera I, Tauc M, Lesage F, Poujeol C, Guy N, Barhanin J, ..
  78. ncbi The locus of temporal preparation effects: evidence from the psychological refractory period paradigm
    Karin M Bausenhart
    Psychologisches Institut, Universitat Tubingen, Friedrichstr 21, 72072 Tubingen, Germany
    Psychon Bull Rev 13:536-42. 2006
    ..Consistent with the prediction of an early locus of temporal preparation, this effect propagated completely to the RT of Task 2 at short SOAs, but propagation diminished virtually to zero at long SOAs.
  79. ncbi Reading aloud is not automatic: processing capacity is required to generate a phonological code from print
    Michael Reynolds
    Department of Psychology, University of Waterloo, Waterloo, Ontario, Canada
    J Exp Psychol Hum Percept Perform 32:1303-23. 2006
    ..Task 1 was a tone discrimination task and Task 2 was reading aloud...
  80. ncbi Role of TASK2 in the control of apoptotic volume decrease in proximal kidney cells
    Sebastien l'Hoste
    UMR CNRS 6548, Universite de Nice Sophia Antipolis, 06108 Nice Cedex 2, France
    J Biol Chem 282:36692-703. 2007
    ..In a previous study, we demonstrated in kidney proximal cells that the TASK2 channel was involved in the K+ efflux that occurred during regulatory volume decrease...
  81. ncbi Effects of selective inhibition of N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) on mice in learning and memory tasks
    Krzysztof Lukawski
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, 20 090 Lublin, Poland
    Eur J Pharmacol 579:202-7. 2008
    ..In the Y-maze task, MK-801 (0.1 mg/kg i.p.) impaired alternation behavior and considerably increased locomotion in the Y-maze and locomotor activity test. These results indicate that NAALADase inhibition may impair alternation behavior...
  82. doi Viewer perspective affects central bottleneck requirements in spatial translation tasks
    Elizabeth A Franz
    Department of Psychology, Otago University, Dunedin, New Zealand
    J Exp Psychol Hum Percept Perform 34:398-412. 2008
    ..Dual tasks consisted of tone discriminations (Task 1) and spatial translations (Task 2) using PRP methods with different manipulations on perceptual and response demands...
  83. doi Relationships between driving simulator performance and driving test results
    J C F de Winter
    BioMechanical Engineering Department, Mechanical, Maritime and Materials Engineering, Delft University of Technology, The Netherlands
    Ergonomics 52:137-53. 2009
    ..45). It is recommended that researchers conduct more large-scale studies into the reliability and validity of simulator measures and on-road driving tests...
  84. doi Comparing ERP concomitant with stimulus-induced and self-paced movements: intracerebral recordings at various cortical sites
    J Louvel
    INSERM U894, Centre Paul Broca, 2ter rue d Alesia, 75014 Paris, France
    Neurophysiol Clin 39:149-58. 2009
    ..To compare the shape, amplitude, and topographical distribution over sensorimotor and centroparietal cortex of two sets of ERP concomitant with the same type of movement (MCP), either visually-triggered (VT-MCP) or self-paced (SP-MCP)...
  85. doi Scientific assessment of endoscopic surgical skills
    Hiroyuki Egi
    Department of Endoscopic Surgery and Surgical Science, Graduate School of Hiroshima University, Hiroshima, Japan
    Minim Invasive Ther Allied Technol 19:30-4. 2010
    ..The aim of task 1 was to move the tip of the endoscopic instrument on the tops of poles from A to C, and task 2 was to move it from the right pole B to the left pole D...
  86. doi Multisession, dual-task psychological refractory period practice benefits older and younger adults equally
    Philip A Allen
    Department of Psychology, University of Akron, Akron, OH 44325 4301, USA
    Exp Aging Res 35:369-99. 2009
    ..Task 1 involved tone discrimination and Task 2 involved simultaneous letter-matching...
  87. doi Objective and subjective measures of pure-tone stream segregation based on interaural time differences
    Christian Füllgrabe
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Hear Res 291:24-33. 2012
    ..requiring listeners to indicate whether they heard one or two streams during presentation of a 30-s long sequence (task 2). The A and B tones had equal but opposite ITDs and had the same or different frequencies of 500 and/or 707 Hz...
  88. pmc Specifying social cognitive processes with a social dual-task paradigm
    Roman Liepelt
    Institute for Psychology, University of Muenster Muenster, Germany
    Front Hum Neurosci 6:86. 2012
    ..dual-task that was made of an automatic imitation task (Person 1: Task 1) and a two-choice number task (Person 2: Task 2)...
  89. doi A pilot study on the effects of cognitive remediation on hemodynamic responses in the prefrontal cortices of patients with schizophrenia: a multi-channel near-infrared spectroscopy study
    Shenghong Pu
    Division of Neuropsychiatry, Department of Brain and Neuroscience, Tottori University Faculty of Medicine, Yonago, Tottori, Japan Electronic address
    Schizophr Res 153:87-95. 2014
    ....
  90. doi The relationship between sympathetic nervous activity and cerebral hemodynamics and oxygenation: a study using skin conductance measurement and functional near-infrared spectroscopy
    Lisa Holper
    Biomedical Optics Research Laboratory BORL, Division of Neonatology, University Hospital Zurich, Frauenklinikstrasse 10, 8091 Zurich, Switzerland Electronic address
    Behav Brain Res 270:95-107. 2014
    ..Our findings are relevant for several neuroscientific research areas seeking to evaluate the interplay between cortical and peripheral affective performance. ..
  91. doi Strategies to combat auditory overload during vehicular command and control
    Sharon M Abel
    Individual Behaviour and Performance Section, Defence Research and Development Canada Toronto Research Centre, 1133 Sheppard Avenue West, Toronto, Ontario, Canada M3K 2C9
    Mil Med 179:1036-42. 2014
    ..Participants encoded only those beginning with a preassigned call sign (Baron or Charlie). For Task 2, they agreed or disagreed with simple equations presented either over loudspeakers, as text on the laptop monitor, ..
  92. doi Bimanual and unimanual convergent goal-directed movement times
    Errol R Hoffmann
    a Department of Systems Engineering and Engineering Management, City University of Hong Kong, Kowloon Tong
    J Mot Behav 47:232-45. 2015
    ..Movements made with low ID showed a small effect of 1- or 2-handed movements, with the effective amplitude of the movement being reduced by about 20% when 2 hands were used. ..
  93. doi The CNS under pathophysiologic attack--examining the role of K₂p channels
    Petra Ehling
    Department of Neurology, University of Munster, Munster, Germany
    Pflugers Arch 467:959-72. 2015
    ..TASK1 and TREK1 channels have a neuroprotective effect on stroke development, whereas TASK2 channels have a detrimental effect on neuronal survival under ischemic conditions...
  94. pmc Dynamic sound localization in cats
    Janet L Ruhland
    Department of Neuroscience and Neuroscience Training Program, University of Wisconsin, Madison, Wisconsin
    J Neurophysiol 114:958-68. 2015
    ..Cats appear to be able to process dynamic auditory cues and execute complex motor adjustments to accurately localize auditory targets during rapid eye-head gaze shifts. ..
  95. ncbi How visual search relates to visual diagnostic performance: a narrative systematic review of eye-tracking research in radiology
    A van der Gijp
    Radiology Department, University Medical Center Utrecht, E01 132, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
    Adv Health Sci Educ Theory Pract . 2016
    ..Experimental research is needed to find out which search strategies can improve image perception in learners...
  96. ncbi Concurrent deployment of visual attention and response selection bottleneck in a dual-task: Electrophysiological and behavioural evidence
    Christina B Reimer
    a Department of Psychology, Humboldt Universitat zu Berlin, Berlin, Germany
    Q J Exp Psychol (Hove) . 2016
    ..The dual-task consisted of an auditory two-choice discrimination Task 1 and a conjunction search Task 2, which were presented at variable temporal intervals (stimulus onset asynchrony, SOA)...
  97. ncbi Fetal Exposure to Low Levels of the Plasticizer DEHP Predisposes the Adult Male Adrenal Gland for Endocrine Disruption
    S Lee
    1 Research Institute of the McGill University Health Centre, Montreal, Quebec H4A 3J1, Canada
    Endocrinology . 2016
    ..that were subjected to both early and late exposure revealed deregulation of genes for the potassium channel Kcnk5 and the retinoid-X receptors (RXR) Rxrα and Rxrβ, indicating that these entities are linked to endocrine ..
  98. doi Characterization of exploratory activity and learning ability of healthy and "schizophrenia-like" rats in a square corridor system (AMBITUS)
    G Horvath
    Department of Physiology, Faculty of Medicine, University of Szeged, H 6720 Szeged, Dom ter 10, Hungary Electronic address
    Physiol Behav 169:155-164. 2017
    ..were exposed to two types of tasks repeatedly in two series: all (16) or only the inside (8) boxes (Task 1 or Task 2, respectively) were baited...
  99. doi Effects of a no-go Task 2 on Task 1 performance in dual - tasking: From benefits to costs
    Markus Janczyk
    Department of Psychology, Eberhard Karls University of Tubingen, Schleichstraße 4, 72076, Tubingen, Germany
    Atten Percept Psychophys . 2016
    When two tasks are combined in a dual-task experiment, characteristics of Task 2 can influence Task 1 performance, a phenomenon termed the backward crosstalk effect (BCE)...
  100. pmc Functional evidence of a role for two-pore domain potassium channels in rat mesenteric and pulmonary arteries
    M J Gardener
    School of Biological Sciences, Stopford Building, University of Manchester, Manchester M13 9PT
    Br J Pharmacol 142:192-202. 2004
    ....
  101. doi Information continuity across the response selection bottleneck: early parallel Task 2 response activation contributes to overt Task 2 performance
    Sandra J Thomson
    Department of Psychology, Neuroscience and Behaviour, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4K1, Canada
    Atten Percept Psychophys 75:934-53. 2013
    Several studies of dual-task performance have demonstrated Task 2 to Task 1 response priming (backward compatibility effects), indicating some degree of parallel response computation for concurrent tasks and suggesting that the well-..

Research Grants62

  1. Validation of a functional MRI-based reward processing task as a non-invasive too
    MARY LOUISE PHILLIPS; Fiscal Year: 2010
    ....
  2. Picture Naming Electrified: Brain Electrophysiological Correlates
    Nathan D Maxfield; Fiscal Year: 2012
    ..Results of this research will have implications for the development of psycholinguistically-focused assessment and treatment tools for stuttering. ..
  3. Diagnostic Biomarkers for Radicular Pain
    Lewis S Hanna; Fiscal Year: 2012
    ....
  4. Development Of An Eye Drop To Treat Presbyopia
    William H Garner; Fiscal Year: 2012
    ..If permanent changes in cornea health are observed, lower dose formulations will be prepared and tested;Task 2. Determine the ocular pharmacokinetics of our co-drug, its metabolites, SAM-cycle intermediates and redox balance...
  5. Executive Function Therapy for Stimulant Addiction
    Warren K Bickel; Fiscal Year: 2012
    ..b>Task 2 will collect data on executive function assessment instruments from controls to develop an operational definition ..
  6. Sensimmer Virtual Phaco Trainer for Cataract Surgery
    P Pat Banerjee; Fiscal Year: 2011
    ..b>Task 2. Develop a Phase II capsulorhexis simulator...
  7. Neural mechanisms mediating inferential reasoning abilities in rats
    CYNTHIA FAST; Fiscal Year: 2013
    ..The results of these experiments can aid in the development of interventions facilitating the use of these cognitive processes in both educational and clinical settings to remediate age-related cognitive decline. ..
  8. Sensitivity to smoking reinforcement in women: menstrual cycle effects
    Elizabeth Van Voorhees; Fiscal Year: 2012
    ....
  9. A NEW MECHANISM FOR TREATING OBESITY
    Salih J Wakil; Fiscal Year: 2012
    ..b>Task 2: Evaluate dose to reduce weight gain and lower triglycerides, LDL and blood glucose...
  10. A new class of biodegradable synthetic biomaterial for seroma prevention
    Michael Craven; Fiscal Year: 2012
    ..b>Task 2 - Determine the range of efficacy in vivo using a model involving the harvesting of the rat latissimus dorsi ..
  11. NEUROPHYSIOLOGICAL & MODELING STUDIES OF LOCUS COERULEUS
    Gary Aston Jones; Fiscal Year: 2000
    ..responsivity to unexpected environmental stimuli. ..
  12. Barbara J Weiland; Fiscal Year: 2014
    ..The proposed K01 award is well aligned with the missions of NIH and NIDA. The project will train a promising scientist and help clarify neurobiological pathways to substance abuse, a significant public health priority. ..
  13. High throughput screening of bacterial collections for surface proteins of commer
    Roy H Hammerstedt; Fiscal Year: 2010
    ..When successfully implemented, an enhanced method for assessing both new clinical paradigms [such as use of biotherapeutics] as well as improving old analyses [suboptimal diagnostic immunoassays] will be attained. ..
  14. IMAGING AND MODELING THERAPEUTIC MECHANISMS OF ACTION
    Peter Fox; Fiscal Year: 2003
    ....
  15. Transcatheter Intra-arterial Perfusion MRI Monitoring of Liver Tumor Embolization
    ANDREW CHRISTIAN LARSON; Fiscal Year: 2010
    ..b>Task 2: To test the hypothesis that TRIP-MRI contrast dose can be optimized intra-procedurally to permit short wash-out ..
  16. Dong Hyun Kim; Fiscal Year: 2014
    ..b>Task 2.1: To determine in vivo targeting efficiency of magnetic nanodisks using both in vivo quantitative MRI ..
  17. SUD &Decision-Making: A Pilot Imaging Study of Parents &Children
    Christina W Hoven; Fiscal Year: 2012
    ....
  18. Tal Raz; Fiscal Year: 2014
    ..b>Task 2: Develop a sensor configuration that can scale to 100s of channels...
  19. Denis G Sukhodolsky; Fiscal Year: 2016
    ....
  20. Radiologists' performance in digital mammography and breast tomosynthesis
    Andrew D A Maidment; Fiscal Year: 2010
    ..b>Task 2: We will design a graphical user interface for the radiologists to report their decisions after each time-..
  21. Self-regulatory Control and Eating: A Neuroimaging Study of Bulimia Nervosa
    Laura A Berner; Fiscal Year: 2013
    ....
  22. Task 2/F04: Pharmacokinetic and Safety/Tox Testing for Therapeutics
    MARA KUMMINS; Fiscal Year: 2011
    ..In addition, it can perform testing of therapeutics for safety and pharmacology, in small animals as well as non-human primates, under GLP where appropriate. ..
  23. Engineered Spores as Fluorogenic Biological Indicators for Sterility Testing
    Boris Rotman; Fiscal Year: 2009
    ..For Task 1, BCR will collaborate with New Horizons Diagnostics Corp. (Columbia, MD). Task 2. To standardize and test the rBI for stability and reproducibility. Task 3...
  24. Engineered Spores as Fluorogenic Biological Indicators for Sterility Testing
    Boris Rotman; Fiscal Year: 2007
    ..b>Task 2. Evaluate the biological indicator prototype by comparing it with conventional biological indicators using spore ..
  25. EVALULATION OF PRENATAL TESTS FOR CHROMOSOMAL DISORDERS
    A Washington; Fiscal Year: 1993
    ..b>Task 2 will consist of detailed interviews with obstetrical patients undergoing genetic counseling at UCSF to assess ..
  26. SBIR TOPIC 294 PHASE 1 - DEVELOPMENT OF GLYCOSYLATION - SPECIFIC RESEARCH
    Yie Hwa Chang; Fiscal Year: 2011
    ..In the Phase I proposal, we propose to generate over 32 chicken polyclonal (Task 1) and 2-3 monoclonal IgY (Task 2) [unreadable] against specific Oglycosylation sites...
  27. Auditory Perception of Drug Names: Neighborhood Effects
    Bruce Lambert; Fiscal Year: 2006
    ..abstract_text> ..
  28. EVALUATOR TRAINING MANIKIN FOR SPASTICITY AND STRENGTH
    DAVID ENGSBERG; Fiscal Year: 2003
    ..b>Task 2: Test the SSKAT...
  29. Portable Brian Injury Biomarker Detection System with Integrated Microdialysis Pr
    Champak Das; Fiscal Year: 2011
    ..system with integrated microdialysis probe Task 1: Design and fabricate ePump driven integrated flow system Task 2: Detection of small molecule brain injury biomarkers Task 3: Detection of large molecule brain injury biomarker ..
  30. Fully Ambulatory Hot Flash Monitoring System
    ROBERT LACKEY; Fiscal Year: 2005
    ..b>Task 2 Ambulatory System Performance in Home Setting - This task will characterize the performance of the PhiloMetron ..
  31. Creating Research Files from CMS Data for Integration with Survey Data
    Thomas MaCurdy; Fiscal Year: 2007
    ..MDS and Medicaid); (3) conduct a pilot project demonstrating the effectiveness of the linkage approach created in Task 2; (4) work with CMS and our project survey partners?which include HRS, PSID and NLTCS?to establish protocols that ..
  32. Development of a Miniaturized EMG Telemetry System
    John Standeven; Fiscal Year: 2001
    ..A miniature transmitter and receiver from Ramsey Electronics will form the nucleus of this unit. Task 2: Test the single channel EMG unit...
  33. BEHAVIOR & HORMONE MEDIATION OF HIPPOCAMPAL NEUROGENESIS
    Diane Lee; Fiscal Year: 2001
    ..abstract_text> ..
  34. BIOMEDICAL (BASIC)
    Abe Abuchowski; Fiscal Year: 2009
    ..a schematic of the process), validation of a clean room at Prolong Pharmaceuticals to meet cGMP specifications (Task 2) and design and construction of the equipment required for the scale up production of PEG-Hb which will be ..
  35. Emotional Reactivity of Intimate Partner Abusers
    JULIA BABCOCK; Fiscal Year: 2003
    ..abstract_text> ..
  36. Anti-curli immunotherapy for bacterial pneumonia
    Kanneganti Murthy; Fiscal Year: 2001
    ..We expect to identify a murine anti-csgA MAb that provides potent protection against E. coli pneumonia induced lethality and pulmonary injury. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE ..
  37. MARKERS FOR STEM CELL-LIKE COLONIC CRYPT BASE CELLS
    Bruce Boman; Fiscal Year: 2004
    ..AIM 2: To determine gene expression patterns and levels for SCE marker genes in abnormal crypts, (FAP crypts). Task 2: compare gene expression levels and patterns in purified whole crypts from FAP vs...
  38. FUNCTIONAL PROPERTIES OF VTA NEURONS
    Ann Kosobud; Fiscal Year: 2000
    ..The proposed experiments will provide a better understanding of the functional relationship among the various neuron subtypes in the VTA, and the contribution of these neurons to motivated behavior. ..
  39. Glycerol Kinase Deficiency as a Model to Understand Met*
    Katrina Dipple; Fiscal Year: 2005
    ..transcriptome analysis in the whole animal model using the glycerol kinase knock-out (gyk k/o) mouse (Specific Aim/Task 2)...
  40. MANAGED CARE, FINANCIAL INCENTIVE & PHYSICIAN PRACTICE
    Carol Simon; Fiscal Year: 2002
    ..b>Task 2: Linked survey of physicians and practices: 2000 physicians and 2000 practice-level decision-makers in 5 states to ..
  41. Affective Dispositions and Attention to Emotion Info.
    RANDALL LARSEN; Fiscal Year: 2004
    ....
  42. Radio Frequency Motion Tracking System
    DAVID ENGSBERG; Fiscal Year: 2003
    ..Virtual movement of the transmitting antenna creates a Doppler shift in the signal at the receiver sensor. Task 2: Evaluation of the 2D device...
  43. Disinhibition and risk for early substance use
    Craig Colder; Fiscal Year: 2002
    ..It will provide data that will inform etiological models of adolescent substance use, specifically with regard to an antisocial pathway. ..
  44. RECEPTOR PROFILING AND COMPOUND LIBRARY SCREENING
    Arthur Weissman; Fiscal Year: 2011
    ..2. To perform binding affinity and/or functional activity assessments of active compounds (Task 2). 3...
  45. RECEPTOR PROFILING AND COMPOUND LIBRARY SCREENING
    EMERICH EISENREICH; Fiscal Year: 2009
    ..2. To perform binding affinity and/or functional activity assessments of active compounds (Task 2). 3...
  46. LOW-COST BIOSENSOR FOR REAL-TIME DIAGNOSIS OF BACTEREMIA
    Boris Rotman; Fiscal Year: 2004
    ..b>Task 2. Evaluating performance of the LEXSAS in terms of selectivity, analyte recovery and assay reproducibility. Task 3...
  47. Emotion Regulation in Suicidal Patients with BPD
    MARSHA LINEHAN; Fiscal Year: 2005
    ..abstract_text> ..
  48. EXERCISE OF PATIENTS WITH HEMIPARETIC STROKE
    Richard Macko; Fiscal Year: 2001
    ....
  49. User adjustable support surfaces for wheelchair comfort
    Douglas Hobson; Fiscal Year: 2004
    ..In sub-task 2 the cost feasibility will be determined...
  50. MACRORESTRICTION MAPPING APPLIED TO CHROMOSOME 5Q
    CAROL WESTBROOK; Fiscal Year: 1990
    ....
  51. CHROMATIC FACTORS IN LOW VISION
    Kenneth Knoblauch; Fiscal Year: 1990
    ....
  52. NTP-CHEMICALS IN LABORATORY ANIMALS
    WARD RICHTER; Fiscal Year: 2000
    ..Base Contract shall consist of Phase 1 (prestart activities) or Diisopropylcarbodiimide (Task 1), Methylene Blue (Task 2), Bromochloroacetic Acid (Task 3), Dibromoacetonitrile (Task 4), Dichloroacetic Acid (Task 5), and ..
  53. Double Jeopardy: Cognitive Decline in Depression & Aging
    VONETTA DOTSON; Fiscal Year: 2004
    ..Accomplishing the aims outlined in this proposal will provide the foundation for future studies examining the effect of aging and depression on cognition and activities of daily living. ..
  54. A Compensatory Functional Neuroanatomy of ADHD
    Julie Schweitzer; Fiscal Year: 2007
    ..A better understanding of strategies used in ADHD has potential educational implications for how children with ADHD learn and targets for treatment. ..
  55. DEVELOPMENTAL TOXICITY TESTING
    CJ PRICE; Fiscal Year: 2000
    ..three tasks: developmental toxicity range- finding studies (Task 1), FDA Segment 2 developmental toxicity testing (Task 2), and evaluation of newborn pups from reproductive toxicity test systems contract (N01-ES-15323) for developmental ..
  56. High resolution cone beam volume CT for breast imaging
    Ruola Ning; Fiscal Year: 2003
    ..abstract_text> ..
  57. ANALYSIS OF HIPPOCAMPAL ENCODING OF BEHAVIORAL DECISIONS
    Robert Hampson; Fiscal Year: 2004
    ....
  58. Cognitive Control Deficits and Formal Thought Disorder
    JOHN KERNS; Fiscal Year: 2005
    ..abstract_text> ..
  59. High resolution cone beam volume CT for breast imaging
    Ruola Ning; Fiscal Year: 2006
    ..abstract_text> ..
  60. ASSESSMENT OF IMPACT OF SUB ABUSE EDUC & PREV PROGRAMS
    LORAND SZALAY; Fiscal Year: 1990
    ..be developed and tested for their potential to identify and measure changes in susceptibility to substance abuse (Task 2)...
  61. Gaq modulation of neuronal K+ channels: novel mechanisms and targets
    Douglas A Bayliss; Fiscal Year: 2011
    ..These experiments will characterize molecular substrates underlying native neuronal neurotransmitter-modulated background K+ currents and examine molecular mechanisms by which they are modulated. ..