KCNH8

Summary

Gene Symbol: KCNH8
Description: potassium voltage-gated channel subfamily H member 8
Alias: ELK, ELK1, Kv12.1, elk3, potassium voltage-gated channel subfamily H member 8, ELK channel 3, ether-a-go-go-like potassium channel 1, ether-a-go-go-like potassium channel 3, hElk1, potassium channel, voltage gated eag related subfamily H, member 8, potassium voltage-gated channel, subfamily H (eag-related), member 8, voltage-gated potassium channel subunit Kv12.1
Species: human

Top Publications

  1. pmc Nuclear factor-kappa B activation by the CXC chemokine melanoma growth-stimulatory activity/growth-regulated protein involves the MEKK1/p38 mitogen-activated protein kinase pathway
    D Wang
    Department of Veterans Affairs, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 276:3650-9. 2001
  2. ncbi Atypical protein kinase C-zeta stimulates thyrotropin-independent proliferation in rat thyroid cells
    N Fernandez
    Center for Experimental Therapeutics, University of Pennsylvania School of Medicine, Philadelphia 19104-6160, USA
    Endocrinology 141:146-52. 2000
  3. ncbi Safety of Brucella abortus strain RB51 in bull elk
    W E Cook
    Department of Veterinary Science, University of Wyoming, Laramie 82070, USA
    J Wildl Dis 36:484-8. 2000
  4. pmc Bartonella spp. isolated from wild and domestic ruminants in North America
    C C Chang
    School of Veterinary Medicine, University of California, Davis, California 95616, USA
    Emerg Infect Dis 6:306-11. 2000
  5. ncbi Health protocol for translocation of free-ranging elk
    J L Corn
    Southeastern Cooperative Wildlife Disease Study, College of Veterinary Medicine, University of Georgia, Athens 30602, USA
    J Wildl Dis 37:413-26. 2001
  6. ncbi Elk-1, C/EBPalpha, and Pit-1 confer an insulin-responsive phenotype on prolactin promoter expression in Chinese hamster ovary cells and define the factors required for insulin-increased transcription
    K K Jacob
    Department of Medicine, New York University School of Medicine, 550 First Ave, New York, NY 10016, USA
    J Biol Chem 276:24931-6. 2001
  7. ncbi Chronic wasting disease of cervids
    M W Miller
    Colorado Division of Wildlife, Wildlife Research Center, 317 West Prospect Road, Fort Collins, CO 80526 2097, USA
    Curr Top Microbiol Immunol 284:193-214. 2004
  8. ncbi Surveys for disease agents in introduced elk in Arkansas and Kentucky
    Joseph L Corn
    Southeastern Cooperative Wildlife Disease Study, College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602, USA
    J Wildl Dis 46:186-94. 2010
  9. pmc Temporal recruitment of the mSin3A-histone deacetylase corepressor complex to the ETS domain transcription factor Elk-1
    S H Yang
    School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    Mol Cell Biol 21:2802-14. 2001
  10. ncbi Comparison of muscle fatty acid profiles and cholesterol concentrations of bison, beef cattle, elk, and chicken
    D C Rule
    Department of Animal Science, University of Wyoming, Laramie 82071 3684, USA
    J Anim Sci 80:1202-11. 2002

Research Grants

  1. Structure and assembly of the fungal prion HET-s
    William N Wan; Fiscal Year: 2013
  2. Mark D Zabel; Fiscal Year: 2016
  3. Characteristics of Prion Entry and Neuroinvasion Following Nasal Cavity Infection
    Anthony E Kincaid; Fiscal Year: 2013
  4. Glenn C Telling; Fiscal Year: 2014
  5. Christina Sigurdson; Fiscal Year: 2016
  6. Genetic Study of the Yeast Prion-Interacting Proteins
    Yury O Chernoff; Fiscal Year: 2010
  7. EDWARD ARTHUR HOOVER; Fiscal Year: 2016
  8. Assessing the Transmissibility of CWD to Humans
    Qingzhong Kong; Fiscal Year: 2010
  9. Candace K Mathiason; Fiscal Year: 2015
  10. Interaction of Prions with Dendritic Cells
    Michael Green; Fiscal Year: 2004

Detail Information

Publications200 found, 100 shown here

  1. pmc Nuclear factor-kappa B activation by the CXC chemokine melanoma growth-stimulatory activity/growth-regulated protein involves the MEKK1/p38 mitogen-activated protein kinase pathway
    D Wang
    Department of Veterans Affairs, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 276:3650-9. 2001
    ..induction of NF-kappaB is independent of the MEK1/ERK cascade, because MGSA/GROalpha failed to increase ERK and ELK activation, and specific chemical inhibitors for MEK1 (PD98059) had no effect on MGSA/GROalpha-enhanced NF-kappaB ..
  2. ncbi Atypical protein kinase C-zeta stimulates thyrotropin-independent proliferation in rat thyroid cells
    N Fernandez
    Center for Experimental Therapeutics, University of Pennsylvania School of Medicine, Philadelphia 19104-6160, USA
    Endocrinology 141:146-52. 2000
    ..Experiments using a luciferase reporter for Elk-1 revealed that PKCzeta overexpressing cells exhibit higher basal Elk-1 transcriptional activity than vector-..
  3. ncbi Safety of Brucella abortus strain RB51 in bull elk
    W E Cook
    Department of Veterinary Science, University of Wyoming, Laramie 82070, USA
    J Wildl Dis 36:484-8. 2000
    Some of the elk (Cervus elaphus nelsoni) of the Greater Yellowstone Area (Wyoming, Idaho, Montana; USA) are infected with Brucella abortus, the bacterium that causes bovine brucellosis...
  4. pmc Bartonella spp. isolated from wild and domestic ruminants in North America
    C C Chang
    School of Veterinary Medicine, University of California, Davis, California 95616, USA
    Emerg Infect Dis 6:306-11. 2000
    ..isolated from 49% of 128 cattle from California and Oklahoma, 90% of 42 mule deer from California, and 15% of 100 elk from California and Oregon...
  5. ncbi Health protocol for translocation of free-ranging elk
    J L Corn
    Southeastern Cooperative Wildlife Disease Study, College of Veterinary Medicine, University of Georgia, Athens 30602, USA
    J Wildl Dis 37:413-26. 2001
    When considering an elk (Cervus elaphus) restoration program, wildlife managers must evaluate the positive and negative elements of translocation...
  6. ncbi Elk-1, C/EBPalpha, and Pit-1 confer an insulin-responsive phenotype on prolactin promoter expression in Chinese hamster ovary cells and define the factors required for insulin-increased transcription
    K K Jacob
    Department of Medicine, New York University School of Medicine, 550 First Ave, New York, NY 10016, USA
    J Biol Chem 276:24931-6. 2001
    ..b>Elk-1 and Sap-1 were the only Ets-related transcription factors tested as chimeras with LexA DNA-binding domain that ..
  7. ncbi Chronic wasting disease of cervids
    M W Miller
    Colorado Division of Wildlife, Wildlife Research Center, 317 West Prospect Road, Fort Collins, CO 80526 2097, USA
    Curr Top Microbiol Immunol 284:193-214. 2004
    ..Three cervid species, mule deer (Odocoileus hemionus), white-tailed deer (O. virginianus), and Rocky Mountain elk (Cervus elaphus nelsoni), are the only known natural hosts of CWD...
  8. ncbi Surveys for disease agents in introduced elk in Arkansas and Kentucky
    Joseph L Corn
    Southeastern Cooperative Wildlife Disease Study, College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602, USA
    J Wildl Dis 46:186-94. 2010
    Surveys for disease agents were conducted in introduced free-ranging elk (Cervus elaphus nelsoni) in Arkansas and Kentucky. Elk had been captured in Colorado and Nebraska and released in Arkansas during 1981-1985...
  9. pmc Temporal recruitment of the mSin3A-histone deacetylase corepressor complex to the ETS domain transcription factor Elk-1
    S H Yang
    School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    Mol Cell Biol 21:2802-14. 2001
    ..Here, we demonstrate that the equilibrium between activation and repression via a single transcription factor, Elk-1, is altered following activation of the Erk mitogen-activated protein kinase cascade...
  10. ncbi Comparison of muscle fatty acid profiles and cholesterol concentrations of bison, beef cattle, elk, and chicken
    D C Rule
    Department of Animal Science, University of Wyoming, Laramie 82071 3684, USA
    J Anim Sci 80:1202-11. 2002
    ..bison (18 mo of age), range beef cows (4 to 7 yr of age), feedlot steers (18 mo of age), free-ranging cow elk (3 to 5 yr of age), and chicken breast. Lipids were analyzed by capillary GLC...
  11. ncbi Wolf presence and increased willow consumption by Yellowstone elk: implications for trophic cascades
    Scott Creel
    Department of Ecology, 310 Lewis Hall, Montana State University, Bozeman, Montana 59717, USA
    Ecology 90:2454-66. 2009
    ..Ecosystem (GYE) have been attributed to a behaviorally mediated trophic cascade from wolves (Canis lupus) to elk (Cervus elaphus) to willows...
  12. ncbi Preliminary observations on the experimental transmission of scrapie to elk (Cervus elaphus nelsoni) by intracerebral inoculation
    A N Hamir
    National Animal Disease Center, Agricultural Research Service, United States Department of Agricultural, Ames, IA 50010, USA
    Vet Pathol 40:81-5. 2003
    To determine the transmissibility of scrapie to Rocky Mountain elk (Cervus elaphus nelsoni), six elk calves were inoculated intracerebrally with brain suspension from sheep naturally affected with scrapie...
  13. ncbi TNF receptor family member BCMA (B cell maturation) associates with TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-kappa B, elk-1, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinase
    A Hatzoglou
    Laboratory of Experimental Endocrinology, Faculty of Medicine, University of Crete, Heraklion, Greece
    J Immunol 165:1322-30. 2000
    ..We also show that overexpression of BCMA in 293 cells activates NF-kappa B, Elk-1, the c-Jun N-terminal kinase, and the p38 mitogen-activated protein kinase...
  14. pmc Immune responses of elk to initial and booster vaccinations with Brucella abortus strain RB51 or 19
    S C Olsen
    Bacterial Diseases of Livestock Research Unit, National Animal Disease Center, Agricultural Research Service, U S Department of Agriculture, Ames, IA 50010, USA
    Clin Vaccine Immunol 13:1098-103. 2006
    Previous studies have suggested that currently available brucellosis vaccines induce poor or no protection in elk (Cervus elaphus nelsoni)...
  15. ncbi The Chernobyl accident. Transport of radionuclides to man living in northern Sweden
    L Olofsson
    Radiation Physics Department, , Sweden
    Acta Oncol 27:841-9. 1988
    ..The most important sources of Cs intake in man were lake fish, elk (European moose) and reindeer. Variations with time was studied in detail for four types of lake fish...
  16. pmc Evaluation of Western blotting methods using samples with or without sodium phosphotungstic acid precipitation for diagnosis of scrapie and chronic wasting disease
    Hongsheng Huang
    Ottawa Laboratory Fallowfield, Animal Diseases Research Institute, Canadian Food Inspection Agency, 3851 Fallowfield Road, Ottawa, Ontario
    Can J Vet Res 69:193-9. 2005
    ..A total of 100 cerebrum samples (52 sheep and 48 elk), including 66 negative (31 sheep, 35 elk) and 34 positive (21 scrapie and 13 CWD positive) samples diagnosed by ..
  17. ncbi Prevalence of chronic wasting disease and bovine tuberculosis in free-ranging deer and elk in South Dakota
    Christopher N Jacques
    Department of Wildlife and Fisheries Sciences, South Dakota State University, Brookings, South Dakota 57007, USA
    J Wildl Dis 39:29-34. 2003
    Heads of hunter-harvested deer and elk were collected throughout South Dakota (USA) and within established chronic wasting disease (CWD) surveillance areas from 1997-2002 to determine infection with CWD and bovine tuberculosis (TB)...
  18. ncbi Behavioral responses of bison and elk in Yellowstone to snowmobiles and snow coaches
    John J Borkowski
    Department of Mathematical Sciences, Montana State University, Bozeman 59717, USA
    Ecol Appl 16:1911-25. 2006
    ..Most vehicles toured the central portion of the park where bison (Bison bison) and elk (Cervus elaphus) concentrate in geothermal areas...
  19. doi Transdisciplinary habitat models for elk and cattle as a proxy for bovine tuberculosis transmission risk
    Ryan K Brook
    Environmental Conservation Lab, Clayton H Riddell Faculty of Environment, Earth, and Resources, University of Manitoba, Winnipeg, Manitoba, Canada
    Prev Vet Med 91:197-208. 2009
    ..Transmission of TB between cattle (Bos taurus) and wild elk (Cervus elaphus) in southwestern Manitoba, Canada remains poorly understood but there is a risk when commingling ..
  20. ncbi Estimating the true prevalence of Mycobacterium bovis in free-ranging elk in Michigan
    Daniel J O'Brien
    Wildlife Disease Laboratory, Michigan Department of Natural Resources, Lansing, Michigan 48910 8106, USA
    J Wildl Dis 44:802-10. 2008
    Although relatively small, Michigan's elk (Cervus elaphus nelsoni) herd is highly valued by both hunters and the general public...
  21. ncbi Neither ERK nor JNK/SAPK MAP kinase subtypes are essential for histone H3/HMG-14 phosphorylation or c-fos and c-jun induction
    E Cano
    Nuclear Signalling Laboratory, Randall Institute, King s College London, UK
    J Cell Sci 108:3599-609. 1995
    ..JNK/SAPKs bind to GST-cJun1-79, and ERKs, particularly ERK-2, to GST-Elk1(307-428); there is no cross-specificity of binding...
  22. ncbi Growth factor-induced transcription via the serum response element is inhibited by cyclic adenosine 3',5'-monophosphate in MCF-7 breast cancer cells
    W L Lowe
    Department of Medicine, Veterans Administration Chicago Healthcare System and Northwestern University Medical School, Chicago, Illinois 60611, USA
    Endocrinology 138:2219-26. 1997
    ..upon the activation by phosphorylation of a ternary complex factor; included among the ternary complex factors is Elk-1...
  23. ncbi Epizootiology of chronic wasting disease in free-ranging cervids in Colorado and Wyoming
    M W Miller
    Colorado Division of Wildlife, Wildlife Research Center, Fort Collins 80526 2097, USA
    J Wildl Dis 36:676-90. 2000
    ..and Rocky Mountain elk (Cervus elaphus nelsoni) populations in contiguous portions of northeastern Colorado and southeastern Wyoming (USA)...
  24. pmc C/EBP beta and Elk-1 synergistically transactivate the c-fos serum response element
    M Hanlon
    Department of Molecular Physiology and Biophysics Vanderbilt University School of Medicine, Nashville, Tennessee USA
    BMC Cell Biol 1:2. 2000
    ..Due to these common observations, we addressed the possibility that C/EBPbeta and Elk-1 could both be necessary for Ras-stimulated transactivation of the SRE.
  25. pmc Transmission of elk and deer prions to transgenic mice
    GULTEKIN TAMGUNEY
    Institute for Neurodegenerative Diseases, University of California San Francisco, 513 Parnassus Ave, San Francisco, CA 94143 0518, USA
    J Virol 80:9104-14. 2006
    Chronic wasting disease (CWD) is a fatal prion disease in deer and elk. Unique among the prion diseases, it is transmitted among captive and free-ranging animals...
  26. ncbi Evaluating prey switching in wolf-ungulate systems
    Robert A Garrott
    Ecology Department, Montana State University, Bozeman, Montana 59717, USA
    Ecol Appl 17:1588-97. 2007
    ..taxa and field data from ongoing wolf-ungulate studies to construct a model of predator diet composition for a wolf-elk-bison system in Yellowstone National Park, Wyoming, USA...
  27. pmc Epidemiology of an outbreak of chronic wasting disease on elk farms in Saskatchewan
    Connie K Argue
    Western Animal Health Program Network, Canadian Food Inspection Agency, Calgary, Alberta
    Can Vet J 48:1241-8. 2007
    An outbreak of chronic wasting disease (CWD) in farmed elk in Saskatchewan from 1996 to 2002 was reviewed to 1, determine the progression of CWD from infection to death in farmed elk; 2, assess animal risk factors for CWD infection in ..
  28. ncbi Effects of management, behavior, and scavenging on risk of brucellosis transmission in elk of western Wyoming
    Eric J Maichak
    Wyoming Game and Fish Department, Pinedale, Wyoming 82941, USA
    J Wildl Dis 45:398-410. 2009
    Brucellosis is endemic in elk (Cervus elaphus nelsoni) using winter feedgrounds of western Wyoming, USA presumably because of increased animal density, duration of attendance, and subsequent contact with aborted fetuses...
  29. ncbi Activation of Elk-1, an Ets transcription factor, by glucose and EGF treatment of insulinoma cells
    E Bernal-Mizrachi
    Division of Endocrinology, Diabetes, and Metabolism, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Physiol Endocrinol Metab 281:E1286-99. 2001
    b>Elk-1, a member of the ternary complex factor family of Ets domain proteins that bind serum response elements, is activated by phosphorylation in a cell-specific manner in response to growth factors and other agents...
  30. ncbi Evaluation of a forage allocation model for Theodore Roosevelt National Park
    Lynn R Irby
    Ecology Department, Montana State University, Bozeman, Montana 59717, USA
    J Environ Manage 64:153-69. 2002
    ..National Park (TRNP), North Dakota determine optimum numbers of four ungulate species, bison (Bison bison), elk (Cervus elaphus), mule deer (Odocoileus hemionus), and feral horses, in the Park...
  31. ncbi Elk browsing increases aboveground growth of water-stressed willows by modifying plant architecture
    Danielle B Johnston
    Colorado Division of Wildlife, 711 Independent Avenue, Grand Junction, CO 81505, USA
    Oecologia 154:467-78. 2007
    In the northern elk wintering range of Yellowstone National Park, USA, wolf (Canis lupus) removal allowed elk (Cervus elaphus) to overbrowse riparian woody plants, leading to the exclusion of beaver (Castor canadensis) and a subsequent ..
  32. pmc Disease-specific motifs can be identified in circulating nucleic acids from live elk and cattle infected with transmissible spongiform encephalopathies
    Paul M K Gordon
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, Sun Center of Excellence for Visual Genomics, University of Calgary, Calgary, AB, Canada T2N 4N1
    Nucleic Acids Res 37:550-6. 2009
    ..spongiform encephalopathies (TSE), we searched for disease-specific patterns in circulating nucleic acids (CNA) in elk and cattle...
  33. ncbi Rapid electrical and delayed molecular signals regulate the serum response element after nerve injury: convergence of injury and learning signals
    Hana Lin
    Department of Anatomy and Cell Biology, 1201 Black Building, Columbia University, West 168th Street, New York, New York 10032, USA
    J Neurobiol 57:204-20. 2003
    ..nerves in Aplysia californica and the sciatic nerve in the mouse and found short- and long-term activation of an Elk1-SRF transcription complex that binds to the serum response element (SRE)...
  34. pmc Mice deficient for the ets transcription factor elk-1 show normal immune responses and mildly impaired neuronal gene activation
    Francesca Cesari
    Abteilung Molekularbiologie, Universitatsklinikum Tubingen, Tubingen, Germany
    Mol Cell Biol 24:294-305. 2004
    The transcription factor Elk-1 belongs to the ternary complex factor (TCF) subfamily of Ets proteins. TCFs interact with serum response factor to bind jointly to serum response elements in the promoters of immediate-early genes (IEGs)...
  35. ncbi Prevalence of neutralizing antibody to Jamestown Canyon virus (California group) in populations of elk and moose in northern Michigan and Ontario, Canada
    P R Grimstad
    Department of Biological Sciences, University of Notre Dame, Indiana 46556
    J Wildl Dis 22:453-8. 1986
    Blood samples were collected from free-ranging elk (Cervus elaphus) harvested in Michigan's northern Lower Peninsula, from moose (Alces alces) relocated from Ontario's Algonquin Provincial Park to Michigan's Upper Peninsula, and from ..
  36. ncbi The functional properties of the human ether-à-go-go-like (HELK2) K+ channel
    Andrea Becchetti
    Dipartimento di Biotecnologie e Bioscienze, Universita di Milano Bicocca, Piazza della Scienza 2, 20126 Milan, Italy
    Eur J Neurosci 16:415-28. 2002
    The voltage-dependent K+ channels belonging to the ether-à-go-go family (eag, erg, elk) are widely expressed in the mammalian CNS. Their neuronal function, however, is poorly understood...
  37. pmc Activation of the human T-cell leukemia virus type 1 long terminal repeat by the ternary complex factor Elk-1
    Heather Y Winter
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, MS 385, One Baylor Plaza, Houston, Texas 77030, USA
    J Virol 81:13075-81. 2007
    ..Binding of the TCF family member Elk-1 to these sites was shown to activate transcription of the promoter...
  38. ncbi A TAT-DEF-Elk-1 peptide regulates the cytonuclear trafficking of Elk-1 and controls cytoskeleton dynamics
    Jeremie Lavaur
    Signalisation Neuronale et Régulations Géniques, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 7102, 75005 Paris, France
    J Neurosci 27:14448-58. 2007
    The transcription factor Elk-1 plays a key role in cell differentiation, proliferation and apoptosis...
  39. ncbi Physiologic effects of nasal oxygen or medical air administered prior to and during carfentanil-xylazine anesthesia in North American elk (Cervus canadensis manitobensis)
    Jessica M Paterson
    Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5B4, Canada
    J Zoo Wildl Med 40:39-50. 2009
    This study compared the physiologic effects of carfentanil-xylazine anesthesia in elk administered nasal oxygen or medical air...
  40. pmc Investigation of the effects of experimental autolysis on the detection of abnormal prion protein in lymphoid and central nervous system tissues from elk and sheep using the Western blotting method
    Hongsheng Huang
    Ottawa Laboratory Fallowfield, Canadian Food Inspection Agency, Ontario, Canada
    Can J Vet Res 75:69-72. 2011
    ..on the detection of abnormal prion protein (PrPsc) in lymphoid and central nervous system (CNS) tissues from elk and sheep...
  41. pmc Transmission of scrapie and sheep-passaged bovine spongiform encephalopathy prions to transgenic mice expressing elk prion protein
    GULTEKIN TAMGUNEY
    Institute for Neurodegenerative Diseases, University of California, San Francisco, CA 94143 0518, USA
    J Gen Virol 90:1035-47. 2009
    ..To address whether prions from sheep might be able to cause disease in cervids, we inoculated mice expressing the elk prion protein (PrP) transgene [Tg(ElkPrP) mice] with two scrapie prion isolates...
  42. ncbi Similarities and differences in the way transmembrane-type ligands interact with the Elk subclass of Eph receptors
    R Brambilla
    European Molecular Biology Laboratory, Heidelberg, Germany
    Mol Cell Neurosci 8:199-209. 1996
    ..that are tethered to the cell surface via a transmembrane domain, and a subset of Eph receptors, the so-called Elk subclass...
  43. ncbi Paresis and death in elk (Cervus elaphus) due to lichen intoxication in Wyoming
    Walter E Cook
    Wyoming Game and Fish Department, 1174 Snowy Range Road, Laramie, Wyoming 82070, USA
    J Wildl Dis 43:498-503. 2007
    During February-April 2004, an estimated 400-500 free-ranging elk (Cervus elaphus) developed paresis, became recumbent, and died or were euthanized in the Red Rim Wildlife Habitat Management Area (RRWHMA), Wyoming, USA...
  44. ncbi Ectoparasites from elk (Cervus elaphus nelsoni) from Wyoming
    W M Samuel
    Department of Zoology, University of Alberta, Edmonton, Canada
    J Wildl Dis 27:446-51. 1991
    Hides of nine elk, collected during the winter of 1986-1987 from the National Elk Refuge, Wyoming (USA) were examined for ectoparasites. Parasites recovered were mites, Psoroptes sp...
  45. ncbi Foot-and-mouth disease in North American bison (Bison bison) and elk (Cervus elaphus nelsoni): susceptibility, intra- and interspecies transmission, clinical signs, and lesions
    Jack Rhyan
    National Wildlife Research Center, Veterinary Services, Animal and Plant Health Inspection Service, US Department of Agriculture, Fort Collins, Colorado 80521, USA
    J Wildl Dis 44:269-79. 2008
    ..about the pathogenesis and epidemiology of foot-and-mouth disease (FMD) in North American bison (Bison bison) or elk (Cervus elaphus nelsoni)...
  46. pmc Mapping brucellosis increases relative to elk density using hierarchical Bayesian models
    Paul C Cross
    Northern Rocky Mountain Science Center, United States Geological Survey, Bozeman, Montana, United States of America
    PLoS ONE 5:e10322. 2010
    ..We applied hierarchical Bayesian methods to a 19-year dataset of over 6400 brucellosis tests of adult female elk (Cervus elaphus) in northwestern Wyoming...
  47. ncbi FLI1 and EWS-FLI1 function as ternary complex factors and ELK1 and SAP1a function as ternary and quaternary complex factors on the Egr1 promoter serum response elements
    D K Watson
    Center for Molecular and Structural Biology, Medical University of South Carolina, Charleston 29425, USA
    Oncogene 14:213-21. 1997
    ..The SRE is a cis-element that regulates the expression of many growth factor responsive genes. ELK1 and SAP1a have been shown to form ternary complexes with SRF on the SRE located in the c-fos promoter...
  48. ncbi Prion protein in cardiac muscle of elk (Cervus elaphus nelsoni) and white-tailed deer (Odocoileus virginianus) infected with chronic wasting disease
    Jean E Jewell
    Department of Veterinary Sciences, University of Wyoming, Wyoming State Veterinary Laboratory WSVL, 1174 Snowy Range Road, Laramie, WY 82070, USA
    J Gen Virol 87:3443-50. 2006
    ..appendicular skeletal muscles from mule deer (Odocoileus hemionus), white-tailed deer (Odocoileus virginianus), elk (Cervus elaphus nelsoni) and moose (Alces alces shirasi) were examined by ELISA, Western immunoblot and ..
  49. ncbi Multiscale wolf predation risk for elk: does migration reduce risk?
    Mark Hebblewhite
    Wildlife Biology Program, Department of Ecosystem and Conservation Sciences, College of Forestry, University of Montana, Missoula, MT 59812, USA
    Oecologia 152:377-87. 2007
    ..We test the predation risk reduction hypothesis at two spatial scales in a partially migratory elk (Cervus elaphus) population by comparing exposure of migrant and resident elk to wolf (Canis lupus) predation risk...
  50. ncbi Mineral deficiencies in tule elk, Owens Valley, California
    Heather E Johnson
    Sierra Nevada Bighorn Sheep Recovery Program, California Department of Fish and Game, 407 West Line Street, Bishop, CA 93514, USA
    J Wildl Dis 43:61-74. 2007
    Male tule elk (Cervus elaphus nannodes) are susceptible to high rates of antler breakage in Owens Valley, California. We hypothesized that a mineral deficiency in the diet predisposed male elk to antler breakage...
  51. pmc Chronic wasting disease of deer and elk in transgenic mice: oral transmission and pathobiology
    Matthew J Trifilo
    Viral Immunobiology Laboratory, Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Virology 365:136-43. 2007
    To study the pathogenesis of chronic wasting disease (CWD) in deer and elk, transgenic (tg) mice were generated that expressed the prion protein (PrP) of deer containing a glycine at amino acid (aa) 96 and a serine at aa 225 under ..
  52. ncbi Blood culture and stimulation conditions for the diagnosis of tuberculosis in cervids by the Cervigam assay
    W R Waters
    Tuberculosis Research Project, National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, IA 50010, USA
    Vet Rec 162:203-8. 2008
    ..to Mycobacterium bovis-infected white-tailed deer and reindeer, M bovis BCG-vaccinated white-tailed deer and elk, and unvaccinated, uninfected white-tailed deer, fallow deer, elk and reindeer...
  53. pmc cDNA cloning and characterization of eck, an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases
    R A Lindberg
    Molecular Biology and Virology Laboratory, Salk Institute for Biological Studies, San Diego, California 92186 5800
    Mol Cell Biol 10:6316-24. 1990
    ..Molecular phylogeny indicates that this protein kinase is closely related to eph and elk and that this receptor family is more closely related to the non-receptor protein-tyrosine kinase families than to ..
  54. ncbi Identification of protein-tyrosine kinase genes preferentially expressed in embryo stomach and gastric cancer
    T Iwase
    First Department of Pathology, Hamamatsu University School of Medicine, Japan
    Biochem Biophys Res Commun 194:698-705. 1993
    ..From nucleotide sequence analysis, these five cDNAs were identified as elk, erk, esk, TTK and fyn, respectively...
  55. ncbi Ligands for the receptor tyrosine kinases hek and elk: isolation of cDNAs encoding a family of proteins
    C J Kozlosky
    Department of Gene Expression, Immunex Research and Development Corporation, Seattle, Washington 98101
    Oncogene 10:299-306. 1995
    Hek is a member of the eph subfamily of receptor tyrosine kinases whose members include elk, hek2, sek, eph and eck among others...
  56. ncbi MAP kinase-dependent transcriptional coactivation by Elk-1 and its cofactor CBP
    R Janknecht
    Institute for Molecular Biology, Hannover Medical School, Germany
    Biochem Biophys Res Commun 228:831-7. 1996
    A plethora of signals induce the c-fos proto-oncogene via phosphorylation of the transcription factor Elk-1 by MAP kinase. We show that the coactivator CBP cooperates with Elk-1 to stimulate c-fos...
  57. ncbi LERK-7: a ligand of the Eph-related kinases is developmentally regulated in the brain
    C J Kozlosky
    Department of Molecular Biology, Immunex Research and Development Corporation, 51 University Street, Seattle, WA, 98101, USA
    Cytokine 9:540-9. 1997
    ..When transfected into CV1/EBNA cells, LERK-7 binds soluble forms of both hek and elk. In addition, a soluble form of LERK-7 will induce phosphorylation of eck expressed in a human duodenum ..
  58. ncbi Two naturally occurring insulin receptor tyrosine kinase domain mutants provide evidence that phosphoinositide 3-kinase activation alone is not sufficient for the mediation of insulin's metabolic and mitogenic effects
    A Krook
    Department of Medicine, Cambridge University, Addenbrookes Hospital, Hills Road, CB2 2QR, Cambridge, United Kingdom
    J Biol Chem 272:30208-14. 1997
    ..that these mutations also impair the ability of the insulin receptor to activate the transcription factor Elk-1 and promote GLUT4 translocation to the plasma membrane...
  59. ncbi Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase
    E Stein
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 273:1303-8. 1998
    ..Within this subdomain, Tyr594 was required for Nck binding. In P19 embryonal carcinoma cells, activation of EphB1 (ELK) by its ligand, ephrin-B1/Fc, recruited Nck to native receptor complexes and activated c-Jun kinase (JNK/SAPK)...
  60. ncbi Functional analysis of a mouse brain Elk-type K+ channel
    M C Trudeau
    Department of Physiology, University of Wisconsin Madison Medical School, Madison, Wisconsin 53706, USA
    J Neurosci 19:2906-18. 1999
    Members of the Ether à go-go (Eag) K+ channel subfamilies Eag, Erg, and Elk are widely expressed in the nervous system, but their neural functions in vivo remain largely unknown...
  61. ncbi New ether-à-go-go K(+) channel family members localized in human telencephalon
    A Miyake
    Molecular Medicine Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, 21 Miyukigaoka, Tsukuba, Ibaraki 305 8585, Japan
    J Biol Chem 274:25018-25. 1999
    ..This protein, termed BEC1, is 46% identical to rat elk in the ether-à-go-go K(+) channel family. The BEC1 gene maps to the 12q13 region of the human genome...
  62. pmc The mechanism of complex formation between Fli-1 and SRF transcription factors
    P Dalgleish
    Department of Biochemistry, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, UK
    Nucleic Acids Res 28:560-9. 2000
    ..A paradigm for this type of complex is the ETS-domain transcription factor Elk-1 and the MADS-box transcription factor SRF which form a ternary complex with the c- fos serum response element (..
  63. ncbi Prostate cancer and the androgen receptor: strategies for the development of novel therapeutics
    L G Mendelsohn
    Cancer Research Division, Eli Lilly and Co, Indianapolis, IN 46285, USA
    Prog Drug Res 55:213-33. 2000
    ..Non-genomic effects of AR to regulate transcription factors elk-1 and -2 have also been demonstrated...
  64. ncbi Protein kinase C (PKC)eta-mediated PKC mu activation modulates ERK and JNK signal pathways
    Ilona Brändlin
    Fraunhofer Institute for Interfacial Engineering, Nobelstrasse 12, University of Stuttgart, Allmandring 31, 70569 Stuttgart, Germany
    J Biol Chem 277:6490-6. 2002
    ..PKC mu/PKD has been implicated in mitogenic signal cascades because of the activation of p42/p44 MAPK leading to Elk1-mediated gene transcription, and PKC mu/PKD has been shown to be activated via a PKC-dependent pathway...
  65. ncbi Brucella abortus strain RB51 vaccination in elk. I. Efficacy of reduced dosage
    Walter E Cook
    Department of Veterinary Science, University of Wyoming, 1174 Snowy Range Road, Laramie, Wyoming 82070, USA
    J Wildl Dis 38:18-26. 2002
    Bovine brucellosis is a serious zoonotic disease affecting some populations of Rocky Mountain elk (Cervus elaphus nelsoni) and bison (Bison bison) in the Greater Yellowstone Area, USA...
  66. ncbi The activity of the extracellular signal-regulated kinase 2 is regulated by differential phosphorylation in the activation loop
    Bo Zhou
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 277:13889-99. 2002
    ..in all phosphorylated forms and kinetically characterized them using two proteins (the myelin basic protein and Elk-1) and ATP as substrates...
  67. ncbi Brucella vaccines in wildlife
    D S Davis
    Department of Veterinary Pathobiology, Texas A and M University, College Station, TX, USA
    Vet Microbiol 90:533-44. 2002
    ..At the beginning of this century in the US, Brucella abortus is a problem in elk and bison in the Greater Yellowstone Area, B...
  68. ncbi Ets transcription factors ER81 and Elk1 regulate the transcription of the human presenilin 1 gene promoter
    Martine Pastorcic
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, 76107, USA
    Brain Res Mol Brain Res 113:57-66. 2003
    ..This assay selected three factors from the Ets family: Ets2, ER81 and Elk1. We show that in vitro translated ER81 indeed binds specifically to the -10 region of the PS1 promoter and that ..
  69. ncbi TRIM45, a novel human RBCC/TRIM protein, inhibits transcriptional activities of ElK-1 and AP-1
    Yuequn Wang
    The Center for Heart Development, College of Life Sciences, Hunan Normal University, Changsha 410081, Hunan, People s Republic of China
    Biochem Biophys Res Commun 323:9-16. 2004
    ..Overexpression of TRIM45 in COS-7 cells inhibits the transcriptional activities of ElK-1 and AP-1...
  70. ncbi Role of Ras/PKCzeta/MEK/ERK1/2 signaling pathway in angiotensin II-induced vascular smooth muscle cell proliferation
    Yali Zhao
    Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing, 100083, China
    Regul Pept 128:43-50. 2005
    ..Phosphorylated and non-phosphorylated PKCzeta, ERK1/2, Elk-1, and mitogen-activated ERK-activating kinase (MEK) were estimated by Western blot analysis...
  71. ncbi Chronic wasting disease of elk: transmissibility to humans examined by transgenic mouse models
    Qingzhong Kong
    Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Neurosci 25:7944-9. 2005
    Chronic wasting disease (CWD), a prion disease affecting free-ranging and captive cervids (deer and elk), is widespread in the United States and parts of Canada...
  72. ncbi Regulating overabundant ungulate populations: an example for elk in Rocky Mountain National Park, Colorado
    John B Bradford
    USDA Forest Service, Northern Research Station, 1831 Hwy 169 E, Grand Rapids, MN 55744, USA
    J Environ Manage 86:520-8. 2008
    ..We constructed a simulation model to evaluate options for regulating elk populations in and around Rocky Mountain National Park and used the model to compare different treatment options...
  73. ncbi A 12-month survey of gastrointestinal helminth infections of cervids kept in two zoos in Belgium
    Els Goossens
    Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B9820 Merelbeke, Belgium
    J Zoo Wildl Med 36:470-8. 2005
    ..At site 2, a wild animal park, involved species were red deer (Cervus elaphus hippelaphus), Nelson's elk (Cervus elaphus nelsoni), Père David's deer (Elaphurus davidianus), European elk (Alces alces alces), and reindeer ..
  74. ncbi Elk use of wallows and potential chronic wasting disease transmission
    Kurt C VerCauteren
    United States Department of Agriculture, Animal and Plant Health Inspection Service, Wildlife Services, National Wildlife Research Center, 4101 LaPorte Avenue, Fort Collins, Colorado 80521 2154, USA
    J Wildl Dis 43:784-8. 2007
    ..We evaluated the role that wallow use by elk (Cervus elaphus) may play in CWD transmission by monitoring wallows with animal-activated cameras throughout their ..
  75. ncbi CCDC134, a novel secretory protein, inhibits activation of ERK and JNK, but not p38 MAPK
    J Huang
    School of Basic Medical Science, Peking University Health Science Center, Beijing, People s Republic of China
    Cell Mol Life Sci 65:338-49. 2008
    ..reveals that overexpression of CCDC134 and its purified protein significantly inhibit transcriptional activity of Elk1 and phosphorylation of Erk and JNK/SAPK but not p38 MAPK...
  76. doi Beneficial effects of low doses of red wine consumption on perturbed shear stress-induced atherogenesis
    Claudio Napoli
    Department of General Pathology, Division of Clinical Pathology, 1st School of Medicine, II University of Naples, Complesso S Andrea delle Dame, Via L De Crecchio 7, Naples, 80138, Italy
    Heart Vessels 23:124-33. 2008
    ..Perturbed shear stress increases also the endothelial expression of oxidation-sensitive responsive genes (such as ELK-1 and p-JUN)...
  77. doi Wildtype Elk-1, but not a SUMOylation mutant, represses egr-1 expression in SH-SY5Y neuroblastomas
    O Demir
    Yeditepe University, Department of Genetics and Bioengineering, Istanbul, Turkey
    Neurosci Lett 437:20-4. 2008
    b>Elk-1, an ETS domain transcription factor of the TCF (ternary complex factor) subfamily, is known to be involved in the regulation of immediate-early genes such as c-fos upon mitogen activation, and thus commonly implied in cell ..
  78. pmc Smad-independent transforming growth factor-beta regulation of early growth response-1 and sustained expression in fibrosis: implications for scleroderma
    Swati Bhattacharyya
    Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Am J Pathol 173:1085-99. 2008
    ..Stimulation by TGF-beta enhanced the transcriptional activity of Elk-1 via the MEK-extracellular signal-regulated kinase 1/2 pathway...
  79. doi Opposite effects of interleukin-1alpha and transforming growth factor-beta2 induce stage-specific regulation of junctional adhesion molecule-B gene in Sertoli cells
    Yang Wang
    Division of Endocrinology, School of Biological Sciences, The University of Hong Kong, Pokfulam, Hong Kong
    Endocrinology 150:2404-12. 2009
    ..of JAM-B is carried out by the binding of specificity proteins (Sps), ETS domain transcription factor Elk-1 (Elk1), neuron-restrictive silencer factor (NRSF), and E2F transcription factor 3 (E2F3) to various cis-acting elements ..
  80. doi CacyBP/SIP binds ERK1/2 and affects transcriptional activity of Elk-1
    Ewa Kilanczyk
    Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology, 3 Pasteur Street, 02 093 Warsaw, Poland
    Biochem Biophys Res Commun 380:54-9. 2009
    ..We also demonstrate that CacyBP/SIP-ERK1/2 interaction inhibits phosphorylation of the Elk-1 transcription factor in vitro and in the nuclear fraction of NB2a cells...
  81. doi Ets-1/Elk-1 is a critical mediator of dipeptidyl-peptidase III transcription in human glioblastoma cells
    Abhay A Shukla
    Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India
    FEBS J 277:1861-75. 2010
    ..This promoter lacked the TATA box but contained multiple GC boxes and a single CAAT box. Similarly, two Ets-1/Elk-1-binding motifs are present in the first 25 nucleotides from the transcription start site...
  82. pmc SENP1 participates in the dynamic regulation of Elk-1 SUMOylation
    James Witty
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, U K
    Biochem J 428:247-54. 2010
    ..The transcription factor Elk-1 [ETS (E twenty-six)-like 1] undergoes rapid de-SUMOylation following cellular stimulation with growth factors, ..
  83. ncbi Epizootic hemorrhagic disease outbreak in a captive facility housing white-tailed deer (Odocoileus virginianus), bison (Bison bison), elk (Cervus elaphus), cattle (Bos taurus), and goats (Capra hircus) in Colorado, U.S.A
    Pauline Nol
    U S Department of Agriculture, Animal and Plant Health Inspection Service Veterinary Services, National Wildlife Research Center, Fort Collins, Colorado 80521, USA
    J Zoo Wildl Med 41:510-5. 2010
    ..on pre- and postoutbreak sera from other species maintained in the same facility, including bison (Bison bison), elk (Cervus elaphus), domestic cattle (Bos taurus), and domestic goats (Capra hircus), as well as postoutbreak sera ..
  84. pmc Association analysis of PRNP gene region with chronic wasting disease in Rocky Mountain elk
    Stephen N White
    Animal Disease Research Unit, Agricultural Research Service, U, S, Department of Agriculture, Pullman, WA 99164, USA
    BMC Res Notes 3:314. 2010
    ..of cervids including white-tailed (Odocoileus virginianus) and mule deer (Odocoileus hemionus), Rocky Mountain elk (Cervus elaphus nelsoni), and moose (Alces alces)...
  85. pmc Quantitative analysis of ERK2 interactions with substrate proteins: roles for kinase docking domains and activity in determining binding affinity
    Kimberly A Burkhard
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland 21201, USA
    J Biol Chem 286:2477-85. 2011
    ..ERK2 interacted with ELK-1 (DEF and DEJL motifs), RSK-1 (DEJL motif), and c-Fos (DEF motif) with K(D) values of 0.25, 0.15, and 0...
  86. doi Experimental interspecies transmission studies of the transmissible spongiform encephalopathies to cattle: comparison to bovine spongiform encephalopathy in cattle
    Amir N Hamir
    Virus and Prion Research Unit, National Animal Disease Center USDA Agricultural Research Service, 1920 Dayton Avenue, PO Box 70, Ames, IA 50010, USA
    J Vet Diagn Invest 23:407-20. 2011
    ..include scrapie of sheep and goats; transmissible mink encephalopathy (TME); chronic wasting disease (CWD) of deer, elk and moose; and bovine spongiform encephalopathy (BSE) of cattle...
  87. pmc Development of a novel genus-specific real-time PCR assay for detection and differentiation of Bartonella species and genotypes
    Maureen H Diaz
    Respiratory Diseases Branch, Division of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Clin Microbiol 50:1645-9. 2012
    ..Using this assay, we identified Bartonella DNA in 29% and 47% of blood specimens from elk in Wyoming and cattle in the Republic of Georgia, respectively...
  88. doi Response of elk to habitat modification near natural gas development
    Fred Van Dyke
    Department of Biology, Wheaton College, Wheaton, IL 60187, USA
    Environ Manage 50:942-55. 2012
    b>Elk (Cervus elaphus) are known to shift habitat use in response to environmental modifications, including those associated with various forms of energy development...
  89. doi Evaluating use of cattle winter feeding areas by elk and white-tailed deer: implications for managing bovine tuberculosis transmission risk from the ground up
    Ryan K Brook
    Department of Animal and Poultry Science and Indigenous Land Management Institute, College of Agriculture and Bioresources, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Prev Vet Med 108:137-47. 2013
    ..The purpose of this study was to quantify co-mingling of elk and white-tailed deer (WTD) with cattle at multiple spatial scales (i.e...
  90. pmc Mediator MED23 plays opposing roles in directing smooth muscle cell and adipocyte differentiation
    Jing wen Yin
    State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Genes Dev 26:2192-205. 2012
    ..absence of Med23 oppositely regulates two sets of genes: the RhoA/MAL targeted cytoskeleton/SMC genes and the Ras/ELK1 targeted growth/adipogenic genes...
  91. pmc Elk1 and AP-1 sites in the TBP promoter mediate alcohol-induced deregulation of Pol III-dependent genes
    Qian Zhong
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Gene 526:54-60. 2013
    ..Furthermore, mutating G>A at a -46 bp Elk1 binding site of the TBP promoter or mutating AP-1 binding site at -37 bp (A>G) and -38 bp (C>T) reduces the ..
  92. doi Sorafenib induces endometrial carcinoma apoptosis by inhibiting Elk-1-dependent Mcl-1 transcription and inducing Akt/GSK3β-dependent protein degradation
    Nian Kang Sun
    Department of Biochemistry and Molecular Biology, Chang Gung University College of Medicine, Taoyuan 333, Taiwan, Republic of China
    J Cell Biochem 114:1819-31. 2013
    ..Sorafenib suppressed Mcl-1 at the gene transactivation level by inactivating the ERK/Elk-1 pathway...
  93. doi Novel polymorphisms in UTR and coding region of inducible heat shock protein 70.1 gene in tropically adapted Indian zebu cattle (Bos indicus) and riverine buffalo (Bubalus bubalis)
    M Sodhi
    National Bureau of Animal Genetic Resources, Karnal 132001, India
    Gene 527:606-15. 2013
    ..In bubaline 5'-UTR, 2 additional putative transcription factor binding sites (Elk-1 and C-Re1) were identified, other than three common sites (CP2, HSE and Pax-4) observed across all the analyzed ..
  94. pmc Habitat selection and risk of predation: re-colonization by lynx had limited impact on habitat selection by roe deer
    Gustaf Samelius
    Department of Ecology, Swedish University of Agricultural Sciences, Riddarhyttan, Sweden
    PLoS ONE 8:e75469. 2013
    ..Limited impact of re-colonization by lynx on habitat selection by roe deer in this study differs from elk in North America altering both daily and seasonal patterns in habitat selection at the spatial scales of habitat ..
  95. pmc Intracellular mGluR5 can mediate synaptic plasticity in the hippocampus
    Carolyn A Purgert
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, and Department of Psychiatry and Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine, St Louis, Missouri 63110
    J Neurosci 34:4589-98. 2014
    ..discovery that intracellular mGluR5 activation drives unique signaling pathways, including upregulation of ERK1/2, Elk-1 (Jong et al., 2009) and Arc (Kumar et al., 2012)...
  96. pmc Inhibition of phosphodiesterase 2 reverses impaired cognition and neuronal remodeling caused by chronic stress
    Ying Xu
    Brain Institute, Department of Pharmacy, School of Pharmacy, Wenzhou Medical College, Wenzhou, China Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY, USA Electronic address
    Neurobiol Aging 36:955-70. 2015
    ..g., Elk-1, TORC1, and CREB phosphorylation) and plasticity-related proteins (e.g...
  97. doi Determination of (4-methylcyclohexyl)methanol isomers by heated purge-and-trap GC/MS in water samples from the 2014 Elk River, West Virginia, chemical spill
    William T Foreman
    U S Geological Survey, National Water Quality Laboratory, PO Box 25585, Denver, CO 80225, USA Electronic address
    Chemosphere 131:217-24. 2015
    ..4-MCHM), the reported major component of the Crude MCHM/Dowanol™ PPh glycol ether material spilled into the Elk River upriver from Charleston, West Virginia, on January 9, 2014...
  98. doi PJ-34 inhibits PARP-1 expression and ERK phosphorylation in glioma-conditioned brain microvascular endothelial cells
    Carla Motta
    Department of Biomedical Sciences and Biotecnology, University of Catania, Via Santa Sofia 64, 95125 Catania, Italy
    Eur J Pharmacol 761:55-64. 2015
    ..laser scanning microscopy (LSM), we analyzed the effects of PJ-34 on PARP-1 expression, phospho-ERK and phospho-Elk-1 activation...
  99. doi Molecular dynamics studies on the buffalo prion protein
    Jiapu Zhang
    a Molecular Model Discovery Laboratory, Faculty of Science, Engineering and Technology, Department of Chemistry and Biotechnology, Swinburne University of Technology, Hawthorn Campus, Hawthorn, Victoria 3122, Australia
    J Biomol Struct Dyn 34:762-77. 2016
    ..goats; bovine spongiform encephalopathy (BSE or "mad-cow" disease) in cattle; chronic wasting disease in deer and elk; and Creutzfeldt-Jakob diseases, Gerstmann-Sträussler-Scheinker syndrome, fatal familial insomnia, and Kulu in ..
  100. doi Validation of a tandem mass spectrometry method using combined extraction of 37 oxylipins and 14 endocannabinoid-related compounds including prostamides from biological matrices
    Sandra Gouveia-Figueira
    Department of Chemistry, Umea University, Umea, Sweden
    Prostaglandins Other Lipid Mediat 121:110-21. 2015
    ..A deeper study of levels in elk, pig and cow brain, as well as cow heart and liver revealed tissue and species-specific elevation of eicosanoids: ..
  101. pmc Dual Specificity Phosphatase 5, a Specific Negative Regulator of ERK Signaling, Is Induced by Serum Response Factor and Elk-1 Transcription Factor
    Camille Buffet
    Endocrinology Metabolism Diabetes Department, Institut Cochin, Universite Paris Descartes, CNRS UMR8104, Inserm U1016, Paris, France
    PLoS ONE 10:e0145484. 2015
    ..These sites potentially bind Elk-1, a transcription factor activated by ERK1/2...

Research Grants63

  1. Structure and assembly of the fungal prion HET-s
    William N Wan; Fiscal Year: 2013
    ..scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle, chronic wasting disease (CWD) in deer and elk, and several forms of Creutzfeldt-Jakob disease (CJD) in humans...
  2. Mark D Zabel; Fiscal Year: 2016
    ..include scrapie in sheep;bovine spongiform encephalopathy (BSE) in cattle;chronic wasting disease (CWD) in deer and elk;and Kuru and Creutzfeldt-Jakob disease in humans...
  3. Characteristics of Prion Entry and Neuroinvasion Following Nasal Cavity Infection
    Anthony E Kincaid; Fiscal Year: 2013
    ..relevance to the horizontal spread of prion disease between animals, such as chronic wasting disease in deer and elk, and scrapie in sheep and goats...
  4. Glenn C Telling; Fiscal Year: 2014
    ..The discoveries of distinct CWD strains, and of prions in deer skeletal muscle and elk antler velvet, have unmistakable relevance to human health...
  5. Christina Sigurdson; Fiscal Year: 2016
    ..Chronic wasting disease (CWD) is an emerging prion disease in deer and elk, transmitted at a rate unparalleled by any other prion disease, and thus may present a risk of infecting humans, ..
  6. Genetic Study of the Yeast Prion-Interacting Proteins
    Yury O Chernoff; Fiscal Year: 2010
    ..Mammalian prion diseases, such as "mad cow" disease and chronic wasting disease of elk and deer, represent a significant health threat due to a possibility of their transmission to humans with infected ..
  7. EDWARD ARTHUR HOOVER; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Chronic wasting disease (CWD) of deer and elk is an emerging highly transmissible prion disease now recognized in 18 States, 2 Canadian provinces, and Korea...
  8. Assessing the Transmissibility of CWD to Humans
    Qingzhong Kong; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Chronic wasting disease (CWD), the prion disease in cervids (deer and elk), is widespread in North America...
  9. Candace K Mathiason; Fiscal Year: 2015
    ..Chronic wasting disease (CWD) is an emergent, efficiently transmitted, fatal prion disease of cervids (deer, elk, moose) that is now identified in 17 states, 2 Canadian provinces and 1 Asian country...
  10. Interaction of Prions with Dendritic Cells
    Michael Green; Fiscal Year: 2004
    ..encephalopathy (BSE), and the observation of an ever-growing outbreak of chronic wasting disease among deer and elk in the United States have brought the issue of prion diseases into the spotlight...
  11. Transmission of Prions Within and Between Species
    Robert Harrington; Fiscal Year: 2006
    ..Chronic Wasting Disease (CWD) is a form of TSE in wild and captive elk, mule deer, and white tail deer...
  12. Characterization of prion protein conformational changes
    VALERIE D DAGGETT; Fiscal Year: 2010
    ..in humans, scrapie in sheep, bovine spongiform encephalopathy in cattle, and chronic wasting disease in deer and elk. While rare, these diseases are always fatal...
  13. Therapeutic Approaches for Prion Disease
    Thomas M Wisniewski; Fiscal Year: 2013
    ..High rates of infection among deer and elk populations have been report, with experimental data indicating that this disease is transmissible to primates...
  14. Structural Characterization of Prion Isoforms in Multiple TSE Diseases
    MICHELE ANN MCGUIRL; Fiscal Year: 2012
    ..Straussler-Scheinker disease, Fatal Familial Insomnia, and kuru (humans), scrapie (sheep), chronic wasting disease (elk, deer), and mad cow disease (cattle)...
  15. Transmissible Spongiform Encephalopathy (Prion) Disease of Deer and Elk
    Laura Solforosi; Fiscal Year: 2007
    ..utilize a transgenic (tg) model we developed to study the pathogenesis of chronic wasting disease (CWD) of deer and elk. At the last review the grant received a 13% score, not sufficient for funding...
  16. Infectious prion generation by mouse transgenesis
    Christina Sigurdson; Fiscal Year: 2009
    ..Based on structural PrP NMR studies of the elk PrP (K...
  17. RAPID TEST FOR TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES
    Elizabeth Williams; Fiscal Year: 2001
    ..Chronic Wasting Disease (CWD) of deer and elk will be used as a model for other TSEs...
  18. Key molecular mechanisms of extraneural pathogenesis and transmission of TSEs
    Mark D Zabel; Fiscal Year: 2012
    ..These include chronic wating disease (CWD) of deer and elk, scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle and Creutzfeldt-Jacob disease and kuru in ..
  19. Pathogenesis Studies in Scrapie (TSE Diseases)
    Michael Oldstone; Fiscal Year: 2003
    ..and its potential for transmission via the food chain to humans and the awareness that the majority of deer and elk on farms as well as 10 to 20% of wild deer and about 1% of elk develop TSE disease (CWD)...
  20. PrP-scrapie transport across intestinal & BBB
    Neena Singh; Fiscal Year: 2007
    ..An emerging concern is the spread of Chronic Wasting Disease (CWD), a prion disease of the deer and elk in certain parts of USA, and the uncertainties regarding its transmission to livestock and humans...
  21. Development of Novel Brucella Vaccine Candidates
    Stacy Ferguson; Fiscal Year: 2004
    ..The prevalence of Brucella abortus infection among elk and bison populations of Yellowstone National Park has raised concerns about reintroduction of B...
  22. Phosphorylation of Prion Protein as a novel mechanism for conversion
    Andrea C LeBlanc; Fiscal Year: 2010
    ..diseases are transmitted through the conversion of the normally inoffensive prion protein of a host (human, bovine, Elk) into a disease-causing protein. The mechanism for the conversion of this protein is unknown...
  23. Mahin D Maines; Fiscal Year: 2015
    ..shown, in addition to its reductase activity, BVR is a Ser/Thr/Tyr kinase, a cellular scaffold/bridge for MEK/ERK/Elk activation, a nuclear transporter of ERK1/2 and hematin, a leucine-zipper (bZip) transcription factor, a regulator ..
  24. Paul R Thompson; Fiscal Year: 2016
    ..Specifically, we demonstrate that crosstalk plays a role in regulating the phosphorylation of ELK1. Additionally, we will take candidate and proteomic approaches to determine the scope of crosstalk between these ..
  25. Mechanism of MAPK Cytoplasmic Retention in Differentiation of ES Cells
    Elizabeth R Smith; Fiscal Year: 2013
    ..of activated MAPK correlates with the degree of phosphorylation of nuclear and cytoplasmic MAPK substrates, such as Elk1 and cPLA2, respectively...
  26. Kyunghee Choi; Fiscal Year: 2016
    ..ER71, Fli1, Erg, Ets1, Ets2, Elk3 and Tel Ets transcription factors as well as GATA2 and Scl are relevant for hematopoietic and vascular development ..
  27. Defining the prion domain of PrP
    James Mastrianni; Fiscal Year: 2006
    ..With the continued threat of bovine spongiform encephalopathy in Europe, and the current spread of chronic wasting disease of deer and elk in the U.S., these studies are urgently needed.
  28. Intracellular mechanisms of cocaine-memory reconsolidation
    Audrey M Wells; Fiscal Year: 2013
    ..1b, which will utilize quantitative Western blotting to characterize changes in the activation of Elk-1, CREB, and zif268, the transcription factors that are likely activated by ERK in the BLA during memory ..
  29. ERK2: Structure, Function and Inhibition
    Kevin N Dalby; Fiscal Year: 2011
    ..A semi-synthetic bisubstrate analog of transcription factor Elk-1, another substrate of ERK1/2, will be constructed to mimic phosphoryl transfer and analyzed in a similar manner...
  30. Ras/ERK control of cell fates
    MEERA VEDAVALLI SUNDARAM; Fiscal Year: 2010
    ..One "general" target of ERK in all three tissues is the Elk1-related Ets transcription factor LIN-1...
  31. A Chromosome 10 QTL Associated with IGF-1 and Bone Mass
    CLIFFORD JAMES ROSEN; Fiscal Year: 2010
    ..We were then able to narrow our QTL to 13cM, eliminated several candidate genes including Socs-2, Kitl, and Elk3 and identified the Igfl gene as the most promising candidate...
  32. D3 Dopamine receptor signaling in the regulation of startle gating
    Wei Li Chang; Fiscal Year: 2010
    ..cyclase activity, PKA activity, CREB phosporylation, c-fos expression, ERK1/2 activity, MSK1 activity, and Elk-1 levels. The order of assays will permit the most efficient assessment of the the targeted signal pathways...
  33. SIGNALS FOR RENAL ENDOTHELIAL CAPILLARY MORPHOGENESIS
    Jin Chen; Fiscal Year: 2001
    ..In this regard, previous studies by this investigator have shown that the ELK subclass of Eph family of receptors are critical in cultured human renal microvascular endothelial cells (HRMEC) ..
  34. Social and emotional skills training with young children
    MELISSA DEROSIER; Fiscal Year: 2004
    ..is to develop and test a research-based emotional intelligence program, entitled "Emotionally Literate Kids" (ELK), for K through 2nd grade students...
  35. MODULATION OF VASCULAR FUNCTION BY HYPOXEMIA/ISCHEMIA
    David Stern; Fiscal Year: 2002
    ..hypoxia activates PKCbetaII, the latter triggers a raf- and MEK-dependent pathway activating MAP kinases and Elk-1; and, activated Elk-1, in concert with Serum Response Factor, induces transcription of Egr-1...
  36. MODULATION OF VASCULAR FUNCTION BY HYPOXEMIA/ISCHEMIA
    David Stern; Fiscal Year: 2000
    ..hypoxia activates PKCbetaII, the latter triggers a raf- and MEK-dependent pathway activating MAP kinases and Elk-1; and, activated Elk-1, in concert with Serum Response Factor, induces transcription of Egr-1...
  37. The contribution of heat shock/stress pathways to acute lung injury
    Jeffrey D Hasday; Fiscal Year: 2010
    ..kinase pathways in vitro leading to activation of the transcription factors heat shock factor-1 (HSF1), ATF2, and Elk- 1...
  38. Development of HTS Assays for Sub-Threshold Potassium Channels
    Timothy Jegla; Fiscal Year: 2006
    ..Among the least characterized are Elk family potassium channels (KCNH3, KCNH4 and KCNH8) which have no distinguishing pharmacology, but are activated at typical neuronal resting potentials and are ..
  39. Disregulation of Calcineurin in Mouse Models of Down Syn
    Katheleen Gardiner; Fiscal Year: 2006
    ..targets, endocytic protein dynamin, apoptosis protein BAD, amyloid plaque component tau, transcription factors Elk, NFATc4, and CREB, and calcineurin inhibitor DSCR1; and (3) dissect the contribution to the calcineurin-related ..
  40. Erythropoietin Signaling Pathways to c-myc and c-fos
    Changmin Chen; Fiscal Year: 2004
    ..kinase (ERK) cascade is involved in the elongation of c-myc and is also involved in the regulation of c-fos by the Elk transcription factor...
  41. CONTROL OF VASCULAR SMOOTH MUSCLE CELL PHENOTYPE BY CGMP
    Thomas Lincoln; Fiscal Year: 2009
    ..SRF-myocardin dependent gene regulation is modulated by many factors including the Ternary Factor Complex protein, Elk-1...
  42. Gail A Robertson; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Eag-related channels (EAG, hERG, ELK) all share a highly conserved region bearing homology with cyclic- nucleotide binding domains of a variety of other proteins including cyclic nucleotide-gated ..
  43. EPH MOLECULES IN OTOGENY OF BRAIN REWARD CIRCUITS
    Renping Zhou; Fiscal Year: 2001
    ..Consistent with this proposal, we have shown Elk, and Eph family receptor, and its ligand, Lerk5, are expressed in complementary patterns in the ventral tegmental ..
  44. DNA MINOR GROOVE BINDING POLYAMIDES
    Terry Beerman; Fiscal Year: 2004
    ..For this purpose, a representative of the Ets oncogenic protein family Elk-1, which binds a serum response element (SRE) contained within the c-fos promoter, was chosen as a model TF...
  45. The role of protein phosphatase 2A in age-related memory impairment
    Michael King; Fiscal Year: 2009
    ..These stimulate levels of nuclear phosphoproteins, such as Elk-1, to form DNA-binding complexes that activate the expression of several genes...
  46. Child Abuse Recognition, Research, Education Translation (CARRET) Conference
    Alison Baker; Fiscal Year: 2006
    ..care provider decision making regarding possible child abuse on September 14-15, 2006 at the AAP Headquarters in Elk Grove Village, IL...
  47. Regulation of IL-2 Gene Expression in T-cell Anergy
    Daniel Mueller; Fiscal Year: 2005
    ..Finally, our work has revealed a role for TCR and CD28 signal integration at the level of the Elk-I transcription factor, and this may prove to be an additional site of regulation by clonal anergy at the c-fos ..
  48. TUMOR HETEROGENEITY CORRELATION TO RADIOSENSITIVITY
    Sydney Evans; Fiscal Year: 1999
    ..The nitroimidazole to be used is pentafluorinated etanidazole (EF5); a monoclonal antibody (ELK3-51) has ben raised against its adducts...
  49. Substrate specific ERK docking domain inhibitors
    Paul S Shapiro; Fiscal Year: 2010
    ..identified inhibited ERK-specific phosphorylation of ribosomal S6 kinase-1 (RSK-1) and the transcription factor ELK-1, both of which promote cell proliferation...
  50. Allosteric JNK modulators for the treatment of diabetes
    Maurizio Pellecchia; Fiscal Year: 2007
    ..have identified a minimal peptide region of JIP1 that inhibits JNK activity in vitro toward recombinant c-jun, Elk, and ATF2 with a remarkable selectivity...
  51. SUMO conjugation in cell biology and Development
    Albert J Courey; Fiscal Year: 2010
    ..Furthermore, the sumoylation of numerous oncoproteins (c-jun, elk-1, and TEL) and tumor suppressor proteins (p53, RB, and PML) modulates their function...
  52. Mechanisms of Ischemic Tolerance
    Valina Dawson; Fiscal Year: 2004
    ..to investigate the role of transcriptional targets of the Ras/Erk signaling cascade with a focus on CREB and Elk activation...
  53. NERVE GROWTH FACTOR REGULATION OF GENE EXPRESSION
    Michael Greenberg; Fiscal Year: 2001
    ..1) The mechanism by which NGF induced phosphorylation of Elk-1 and CREB triggers c-fos transcription will be investigated...
  54. Chemokine Signaling in Monocyte Recruitment In Vivo
    Robert Gerszten; Fiscal Year: 2002
    ..3-K works through downstream activation of substrates which include Akt, cytohesin- I and integrin linked kinase (ELK)...
  55. FUNCTIONAL ANALYSIS OF THE HUMAN ELK-1 GENE
    Veena Rao; Fiscal Year: 2000
    ..Previously, we have identified and characterized a new member of this oncogene family elk-1. Recently, we have shown that elk-1 is a transcriptional activator which regulates c-fos oncogene activity...
  56. Elk-1 localization, regulation and function in dendrites
    Lindy Barrett; Fiscal Year: 2005
    ..This proposal specifically addresses the regulation and function of the transcription factor Elk-1, which is localized to both proximal and distal dendrites...
  57. GAB2 AND A NOVEL CYTOPLASMIC NUCLEAR SIGNALING MECHANISM
    Gen Sheng Feng; Fiscal Year: 2005
    ..in coupling cytoplasmic-nuclear signaling, and that Gab2 acts to suppress the activity of the transcription factor Elk-i induced by oncogenic RasV 12 or epidermal growth factor, without down-regulating extracellular signal-regulated ..
  58. FUNCTIONAL DISSECTION OF HUMAN C-ETS-1 GENE
    E Reddy; Fiscal Year: 1993
    ..Our recent results suggest ets-1 and the other members of ets oncogene (ets-2, erg- 1, erg-2, and elk-1) are all DNA binding proteins...
  59. Regulation of the MAP Kinase Pathway in Senescence
    George Prendergast; Fiscal Year: 2005
    ..This was consistent with the failure of senescent cells to phosphorylate p-ERK?s target, Elk-1. The experiments proposed in this project will address the mechanism of failed translocation of nuclear p-ERK...
  60. Investigation of LIN-1 and its inhibitor MPK-1
    ELIZABETH LEIGHT; Fiscal Year: 2004
    ..The Elk subfamily of ETS proteins, which includes C. elegans LIN-1, are conserved targets for MAPK...
  61. DETERMINANTS OF TISSUE ESTRADIOL SENSITIVITY
    Richard Santen; Fiscal Year: 2009
    ..FTS, a novel mTOR inhibitor will be used in vitro to activate the stress kinase pathway and apoptosis. In vivo, FTS will be used to enhance estradiol induced apoptosis in nude mice. ..
  62. ROLE OF THE CELL CYCLE IN HYPERSENSITIVITY TO ESTRADIOL
    Richard Santen; Fiscal Year: 2008
    ..A clinical trial in women, which is designed to specifically demonstrate that high dose estrogen induces tumor regression through the mechanism of apoptosis will be conducted. ..
  63. DEVELOPMENTAL SIGNAL INTEGRATION BY FETAL LUNG FIBROBLAS
    Matthew Lee; Fiscal Year: 2003
    ..Feedback regulation of MAP kinase activity will be investigated by determining if Elk-1, a downstream mediator of MAP kinase, modulates Shc isoform expression...