KCNE1

Summary

Gene Symbol: KCNE1
Description: potassium voltage-gated channel subfamily E regulatory subunit 1
Alias: ISK, JLNS, JLNS2, LQT2/5, LQT5, MinK, potassium voltage-gated channel subfamily E member 1, IKs producing slow voltage-gated potassium channel subunit beta Mink, cardiac delayed rectifier potassium channel protein, delayed rectifier potassium channel subunit IsK, minimal potassium channel, potassium channel, voltage gated subfamily E regulatory beta subunit 1, potassium voltage-gated channel, Isk-related family, member 1, potassium voltage-gated channel, Isk-related subfamily, member 1, voltage gated potassiun channel accessory subunit
Species: human

Top Publications

  1. pmc Characterization of chimeric full-length molecular clones of Aleutian mink disease parvovirus (ADV): identification of a determinant governing replication of ADV in cell culture
    M E Bloom
    Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, Montana 59840
    J Virol 67:5976-88. 1993
  2. ncbi A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndrome
    N Neyroud
    INSERM UR153, Groupe Hospitalier Pitié Salpérrière, Institut de Myologie, Paris, France
    Nat Genet 15:186-9. 1997
  3. pmc Altered potassium balance and aldosterone secretion in a mouse model of human congenital long QT syndrome
    I Arrighi
    Institut de Pharmacologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, 660, route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
    Proc Natl Acad Sci U S A 98:8792-7. 2001
  4. pmc Functional interactions between KCNE1 C-terminus and the KCNQ1 channel
    Jerri Chen
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA
    PLoS ONE 4:e5143. 2009
  5. ncbi Molecular cloning and sequence analysis of human genomic DNA encoding a novel membrane protein which exhibits a slowly activating potassium channel activity
    T Murai
    Institute for Immunology, Kyoto University, Faculty of Medicine, Japan
    Biochem Biophys Res Commun 161:176-81. 1989
  6. pmc Interaction of KCNE subunits with the KCNQ1 K+ channel pore
    Gianina Panaghie
    Greenberg Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, 520 East 70th Street, New York, NY 10021, USA
    J Physiol 570:455-67. 2006
  7. pmc Stoichiometry of the KCNQ1 - KCNE1 ion channel complex
    Koichi Nakajo
    Division of Biophysics and Neurobiology, National Institute for Physiological Sciences, Okazaki, Aichi 444 8585, Japan
    Proc Natl Acad Sci U S A 107:18862-7. 2010
  8. pmc KCNE1 enhances phosphatidylinositol 4,5-bisphosphate (PIP2) sensitivity of IKs to modulate channel activity
    Yang Li
    Department of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University, St Louis, MO 63130, USA
    Proc Natl Acad Sci U S A 108:9095-100. 2011
  9. ncbi Localization of a potassium channel gene (KCNE1) to 21q22.1-q22.2 by in situ hybridization and somatic cell hybridization
    C Chevillard
    INSERM U242, Faculte de Medecine de la Timone, Marseille, France
    Genomics 15:243-5. 1993
  10. ncbi Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel
    M C Sanguinetti
    Department of Medicine, Cardiology Division, University of Utah, Salt Lake City 84112, USA
    Nature 384:80-3. 1996

Research Grants

  1. Structural Analysis of Voltage-gated Potassium Channels
    ROBERT BLAUSTEIN; Fiscal Year: 2006
  2. MOLECULAR DETERMINANTS OF POTASSIUM CHANNEL DRUG BLOCK
    Dirk Snyders; Fiscal Year: 2003
  3. Role of KVS and MPS Subunits in Basic Neuronal Function
    Federico Sesti; Fiscal Year: 2007
  4. Towards the Physiologic Function of MiRP-3
    Daniel I Levy; Fiscal Year: 2010
  5. INTERCELLULAR COMMUNICATION AND IMPULSE PROPAGATION
    JOSE S JALIFE; Fiscal Year: 2010
  6. Geoffrey W Abbott; Fiscal Year: 2015
  7. MOLECULAR BASIS FOR DRUG INDUCED CARDIOTOXICITY IN AIDS
    CRAIG CLARKSON; Fiscal Year: 2001
  8. TARGETING HERG: A MOUSE MODEL OF THE LONG QT SYNDROME
    Barry London; Fiscal Year: 2002
  9. Neural Interactions Among Multiple Motor Structures
    Marc H Schieber; Fiscal Year: 2010
  10. TRANSCRIPTIONAL CONTROL OF MAMMALIAN BRAIN DEVELOPMENT
    Eseng Lai; Fiscal Year: 2001

Detail Information

Publications180 found, 100 shown here

  1. pmc Characterization of chimeric full-length molecular clones of Aleutian mink disease parvovirus (ADV): identification of a determinant governing replication of ADV in cell culture
    M E Bloom
    Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, Montana 59840
    J Virol 67:5976-88. 1993
    The ADV-G strain of Aleutian mink disease parvovirus (ADV) is nonpathogenic for mink but replicates permissively in cell culture, whereas the ADV-Utah 1 strain is highly pathogenic for mink but replicates poorly in cell culture...
  2. ncbi A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndrome
    N Neyroud
    INSERM UR153, Groupe Hospitalier Pitié Salpérrière, Institut de Myologie, Paris, France
    Nat Genet 15:186-9. 1997
    ..Taken together, our data indicate that KVLQT1 is responsible for both JLN and RW syndromes and has a key role not only in the ventricular repolarization but also in normal hearing, probably via the control of endolymph homeostasis...
  3. pmc Altered potassium balance and aldosterone secretion in a mouse model of human congenital long QT syndrome
    I Arrighi
    Institut de Pharmacologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, 660, route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
    Proc Natl Acad Sci U S A 98:8792-7. 2001
    ..responsible for the slowly activating delayed K(+) current I(Ks) is composed of pore-forming KCNQ1 and regulatory KCNE1 subunits, which are mutated in familial forms of cardiac long QT syndrome...
  4. pmc Functional interactions between KCNE1 C-terminus and the KCNQ1 channel
    Jerri Chen
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA
    PLoS ONE 4:e5143. 2009
    The KCNE1 gene product (minK protein) associates with the cardiac KvLQT1 potassium channel (encoded by KCNQ1) to create the cardiac slowly activating delayed rectifier, I(Ks)...
  5. ncbi Molecular cloning and sequence analysis of human genomic DNA encoding a novel membrane protein which exhibits a slowly activating potassium channel activity
    T Murai
    Institute for Immunology, Kyoto University, Faculty of Medicine, Japan
    Biochem Biophys Res Commun 161:176-81. 1989
    ....
  6. pmc Interaction of KCNE subunits with the KCNQ1 K+ channel pore
    Gianina Panaghie
    Greenberg Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, 520 East 70th Street, New York, NY 10021, USA
    J Physiol 570:455-67. 2006
    KCNQ1 alpha subunits form functionally distinct potassium channels by coassembling with KCNE ancillary subunits MinK and MiRP2. MinK-KCNQ1 channels generate the slowly activating, voltage-dependent cardiac IKs current...
  7. pmc Stoichiometry of the KCNQ1 - KCNE1 ion channel complex
    Koichi Nakajo
    Division of Biophysics and Neurobiology, National Institute for Physiological Sciences, Okazaki, Aichi 444 8585, Japan
    Proc Natl Acad Sci U S A 107:18862-7. 2010
    The KCNQ1 voltage-gated potassium channel and its auxiliary subunit KCNE1 play a crucial role in the regulation of the heartbeat...
  8. pmc KCNE1 enhances phosphatidylinositol 4,5-bisphosphate (PIP2) sensitivity of IKs to modulate channel activity
    Yang Li
    Department of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University, St Louis, MO 63130, USA
    Proc Natl Acad Sci U S A 108:9095-100. 2011
    ..Here we show that the auxiliary subunit of I(Ks), KCNE1, increases PIP(2) sensitivity 100-fold over channels formed by the pore-forming KCNQ1 subunits alone, which ..
  9. ncbi Localization of a potassium channel gene (KCNE1) to 21q22.1-q22.2 by in situ hybridization and somatic cell hybridization
    C Chevillard
    INSERM U242, Faculte de Medecine de la Timone, Marseille, France
    Genomics 15:243-5. 1993
  10. ncbi Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel
    M C Sanguinetti
    Department of Medicine, Cardiology Division, University of Utah, Salt Lake City 84112, USA
    Nature 384:80-3. 1996
    ..of the I(Ks) channel is not known, but physiological data indicate that one component of the I(Ks), channel is minK, a 130-amino-acid protein with a single putative transmembrane domain...
  11. ncbi A minK-HERG complex regulates the cardiac potassium current I(Kr)
    T V McDonald
    Section of Molecular Cardiology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Nature 388:289-92. 1997
    b>MinK is a widely expressed protein of relative molecular mass approximately 15K that forms potassium channels by aggregation with other membrane proteins...
  12. pmc Properties of KvLQT1 K+ channel mutations in Romano-Ward and Jervell and Lange-Nielsen inherited cardiac arrhythmias
    C Chouabe
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
    EMBO J 16:5472-9. 1997
    ..Expression studies revealed that the association of KvLQT1 with another subunit, IsK, reconstitutes a channel responsible for the IKs current involved in ventricular myocyte repolarization...
  13. ncbi Mutation of the gene for IsK associated with both Jervell and Lange-Nielsen and Romano-Ward forms of Long-QT syndrome
    P Duggal
    Department of Cardiology, Children s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Circulation 97:142-6. 1998
    ..IsK, an apparent potassium channel subunit encoded by KCNE1 on chromosome 21, regulates both KVLQT1 and HERG...
  14. ncbi Cellular dysfunction of LQT5-minK mutants: abnormalities of IKs, IKr and trafficking in long QT syndrome
    L Bianchi
    The Rammelkamp Center for Education and Research, MetroHealth Campus, Case Western Reserve University, 2500 MetroHealth Drive, Cleveland, OH 44109 1998, USA
    Hum Mol Genet 8:1499-507. 1999
    Mutations in the minK gene KCNE1 have been linked to the LQT5 variant of human long QT syndrome...
  15. ncbi Spectrum of mutations in long-QT syndrome genes. KVLQT1, HERG, SCN5A, KCNE1, and KCNE2
    I Splawski
    Department of Human Genetics, Howard Hughes Medical Institute, Division of Cardiology, Salt Lake City, Utah, USA
    Circulation 102:1178-85. 2000
    ..Five genes have been implicated in Romano-Ward syndrome, the autosomal dominant form of LQTS: KVLQT1, HERG, SCN5A, KCNE1, and KCNE2...
  16. pmc KCNE2 confers background current characteristics to the cardiac KCNQ1 potassium channel
    N Tinel
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS UPR 411, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
    EMBO J 19:6326-30. 2000
    ..The KCNE family comprises at least three members. KCNE1 (IsK or MinK) recapitulates I(Ks) when associated with KCNQ1, whereas it augments the amplitude of an I(Kr)-like ..
  17. ncbi Structural determinants of KvLQT1 control by the KCNE family of proteins
    Y F Melman
    Section of Molecular Cardiology, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 276:6439-44. 2001
    KvLQT1 is a Shaker-like voltage-gated potassium channel that when complexed with minK (KCNE1) produces the slowly activating delayed rectifier I(ks)...
  18. ncbi Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel
    Steven O Marx
    Department of Pharmacology, Center for Molecular Cardiology, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Science 295:496-9. 2002
    ..Yotiao binds to hKCNQ1 by a leucine zipper motif, which is disrupted by an LQTS mutation (hKCNQ1-G589D). Identification of the hKCNQ1 macromolecular complex provides a mechanism for SNS modulation of cardiac APD through IKS...
  19. ncbi Association of the human minK gene 38G allele with atrial fibrillation: evidence of possible genetic control on the pathogenesis of atrial fibrillation
    Ling Ping Lai
    Institute of Pharmacology, National Taiwan University, Taipei, Taiwan
    Am Heart J 144:485-90. 2002
    Human minK protein is the beta-subunit of I(Ks) potassium channel and plays an important role in cardiac cellular electrophysiology...
  20. ncbi KCNQ1 gain-of-function mutation in familial atrial fibrillation
    Yi Han Chen
    Department of Cardiology, Tongji Hospital, and Institute of Medical Genetics, Tongji University, 399 Xin Cun Road, Shanghai 200065, People s Republic of China
    Science 299:251-4. 2003
    ..5. The KCNQ1 gene encodes the pore-forming alpha subunit of the cardiac I(Ks) channel (KCNQ1/KCNE1), the KCNQ1/KCNE2 and the KCNQ1/KCNE3 potassium channels...
  21. ncbi Charybdotoxin binding in the I(Ks) pore demonstrates two MinK subunits in each channel complex
    Haijun Chen
    Department of Pediatrics, Boyer Center for Molecular Medicine, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
    Neuron 40:15-23. 2003
    I(Ks) voltage-gated K(+) channels contain four pore-forming KCNQ1 subunits and MinK accessory subunits in a number that has been controversial...
  22. ncbi Four potassium channel mutations account for 73% of the genetic spectrum underlying long-QT syndrome (LQTS) and provide evidence for a strong founder effect in Finland
    Heidi Fodstad
    Research Program in Molecular Medicine, Biomedicum Helsinki, Finland
    Ann Med 36:53-63. 2004
    Mutations in five cardiac voltage-gated ion channel genes, including KCNQ1, HERG, SCN5A, KCNE1 and KCNE2, constitute the principal cause of inherited long-QT syndrome (LQTS)...
  23. ncbi KCNQ1/KCNE1 channels during germ-cell differentiation in the rat: expression associated with testis pathologies
    Irini Tsevi
    Molecular Physiology Laboratory, Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Barcelona, Spain
    J Cell Physiol 202:400-10. 2005
    KCNQ1/KCNE1 channels are responsible for the Jervell-Lange-Nielsen cardiac syndrome, which is also characterized by congenital deafness. KCNQ1/KCNE1 is crucial for K+ transport in the inner ear...
  24. ncbi Expression of multiple KCNE genes in human heart may enable variable modulation of I(Ks)
    Andrew L Lundquist
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Mol Cell Cardiol 38:277-87. 2005
    ..In the human genome, KCNE proteins are encoded by five genes designated KCNE1 through KCNE5...
  25. ncbi Common variants in myocardial ion channel genes modify the QT interval in the general population: results from the KORA study
    Arne Pfeufer
    Institute of Human Genetics, Technical University Munich, Munich, Germany
    Circ Res 96:693-701. 2005
    ..Using a two-step design we analyzed 174 SNPs from the KCNQ1, KCNH2, KCNE1, and KCNE2 genes in 689 individuals from the population-based KORA study and 14 SNPs with results suggestive of ..
  26. ncbi Compendium of cardiac channel mutations in 541 consecutive unrelated patients referred for long QT syndrome genetic testing
    David J Tester
    Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Heart Rhythm 2:507-17. 2005
    ..The purpose of this study was to determine the spectrum and prevalence of cardiac channel mutations among a large cohort of consecutive, unrelated patients referred for long QT syndrome (LQTS) genetic testing...
  27. ncbi Denaturing high-performance liquid chromatography screening of the long QT syndrome-related cardiac sodium and potassium channel genes and identification of novel mutations and single nucleotide polymorphisms
    Ling Ping Lai
    Institute of Pharmacology, National Taiwan University Hospital, Taipei, Taiwan
    J Hum Genet 50:490-6. 2005
    ..identified the mutation(s) in all four patients with congenital LQTS (KCNQ1 A341V, KCNH2 N633D, KCNH2 2768Cdel and KCNE1 K70 N Y81C double mutations)...
  28. ncbi The single nucleotide polymorphisms of I(Ks) potassium channel genes and their association with atrial fibrillation in a Chinese population
    Zhiyu Zeng
    Center for Arrhythmia Diagnosis and Treatment, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Cardiology 108:97-103. 2007
    ..We investigated the association between AF and the single nucleotide polymorphisms (SNPs) of genes KCNQ1, KCNE1 and KCNE4 associated with this channel...
  29. ncbi KCNE1 subunits require co-assembly with K+ channels for efficient trafficking and cell surface expression
    Kshama D Chandrasekhar
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 281:40015-23. 2006
    ..enzymatic deglycosylation, immunofluorescence, and quantitative cell surface labeling experiments, we show that KCNE1 peptides are retained in the early stages of the secretory pathway until they co-assemble with specific K(+) ..
  30. ncbi MinK gene polymorphism in the pathogenesis of lone atrial fibrillation
    Andrzej Prystupa
    Katedra i Klinika Chorób Wewnetrznych Akademii Medycznej im prof Feliksa Skubiszewskiego, Samodzielny Publiczny Szpital Kliniczny Nr 1, ul Staszica 16, 20 081 Lublin
    Kardiol Pol 64:1205-11; discussion 1212-3. 2006
    ..Atrial fibrillation (AF) is the most common type of complex arrhythmia found in everyday clinical practice. Lone AF is a particular form occurring in 2% to 31% of patients with confirmed AF. Genetic factors may underline this arrhythmia...
  31. ncbi Torsades de pointes complicating atrioventricular block: evidence for a genetic predisposition
    Philippe Chevalier
    Hopital Cardiologique, Hospices Civils de Lyon, Lyon, France
    Heart Rhythm 4:170-4. 2007
    ..The prevalence of genetic risk factors has not been systematically evaluated in the setting of complete atriventricular (AV) block complicated by long QT syndrome (LQTS)...
  32. pmc Preparation, functional characterization, and NMR studies of human KCNE1, a voltage-gated potassium channel accessory subunit associated with deafness and long QT syndrome
    Changlin Tian
    Department of Biochemistry, Center for Structural Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 8725, USA
    Biochemistry 46:11459-72. 2007
    b>KCNE1, also known as minK, is a member of the KCNE family of membrane proteins that modulate the function of KCNQ1 and certain other voltage-gated potassium channels (KV)...
  33. pmc Structure of KCNE1 and implications for how it modulates the KCNQ1 potassium channel
    Congbao Kang
    Department of Biochemitry, Vanderbilt University, Nashville, Tennessee 37232, USA
    Biochemistry 47:7999-8006. 2008
    b>KCNE1 is a single-span membrane protein that modulates the voltage-gated potassium channel KCNQ1 (K V7...
  34. ncbi [Study on the correlation between CETP TaqIB, KCNE1 S38G and eNOS T-786C gene polymorphisms for predisposition and non-valvular atrial fibrillation]
    Li xin Xu
    Department of Cardiovascular Medicine, The First Affiliated Hospital, Wenzhou Medical College, Wenzhou 325027, China
    Zhonghua Liu Xing Bing Xue Za Zhi 29:486-92. 2008
    To study whether CETP TaqIB,KCNE1 S38G and eNOS T-786C genetic polymorphisms are associated with non-valvular atrial fibrillation in the Han population from Zhejiang province.
  35. pmc Common candidate gene variants are associated with QT interval duration in the general population
    A Marjamaa
    Research Program in Molecular Medicine, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    J Intern Med 265:448-58. 2009
    ..As 30-40% of the QT-interval variability is heritable, we tested the association of common LQTS and NOS1AP gene variants with QT interval in a Finnish population-based sample...
  36. pmc Location of KCNE1 relative to KCNQ1 in the I(KS) potassium channel by disulfide cross-linking of substituted cysteines
    David Y Chung
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 106:743-8. 2009
    ..is carried by a complex of KCNQ1 (Q1) subunits, containing the voltage-sensor domains and the pore, and auxiliary KCNE1 (E1) subunits, required for the characteristic I(KS) voltage dependence and kinetics...
  37. pmc Common variants at ten loci influence QT interval duration in the QTGEN Study
    Christopher Newton-Cheh
    Center for Human Genetic Research, Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA
    Nat Genet 41:399-406. 2009
    ..We observed associations at P < 5 x 10(-8) with variants in NOS1AP, KCNQ1, KCNE1, KCNH2 and SCN5A, known to be involved in myocardial repolarization and mendelian long-QT syndromes...
  38. pmc Dynamic partnership between KCNQ1 and KCNE1 and influence on cardiac IKs current amplitude by KCNE2
    Min Jiang
    Department of Physiology and Biophysics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    J Biol Chem 284:16452-62. 2009
    Cardiac slow delayed rectifier (IKs) channel is composed of KCNQ1 (pore-forming) and KCNE1 (auxiliary) subunits...
  39. pmc Augmented potassium current is a shared phenotype for two genetic defects associated with familial atrial fibrillation
    Robert L Abraham
    Division of Cardiovascular Medicine, Vanderbilt University School of Medicine, 1285A MRB IV, 2311 Pierce Avenue, Nashville, TN 37232 6602, USA
    J Mol Cell Cardiol 48:181-90. 2010
    ..In Chinese Hamster Ovary (CHO) cells, coexpression of mutant KCNQ1 with its ancillary subunit KCNE1 generated approximately 3-fold larger currents that activated much faster than wild-type (WT)-I(Ks)...
  40. ncbi Interactions of MinK and e-NOS gene polymorphisms appear to be inconsistent predictors of atrial fibrillation propensity, but long alleles of ESR1 promoter TA repeat may be a promising marker
    Anton Smalcelj
    Department of Cardiovascular Diseases, University Hospital Centre Zagreb, School of Medicine, University of Zagreb, Zagreb, Croatia
    Coll Antropol 33:933-7. 2009
    Interactions of MinK and e-NOS Gene Polymorphisms Appear to Be Inconsistent Predictors of Atrial Fibrillation Propensity, but Long Alleles of ESR1 Promoter TA Repeat May Be a Promising Marker...
  41. pmc Identification of a protein-protein interaction between KCNE1 and the activation gate machinery of KCNQ1
    Anatoli Lvov
    Department of Biochemistry and Molecular Pharmacology, Programs in Neuroscience and Chemical Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Gen Physiol 135:607-18. 2010
    KCNQ1 channels assemble with KCNE1 transmembrane (TM) peptides to form voltage-gated K(+) channel complexes with slow activation gate opening...
  42. doi Impact of KCNE subunits on KCNQ1 (Kv7.1) channel membrane surface targeting
    Meritxell Roura-Ferrer
    Molecular Physiology Laboratory, Departament de Bioquimica i Biologia Molecular, Institut de Biomedicina IBUB, Universitat de Barcelona, Barcelona, Spain
    J Cell Physiol 225:692-700. 2010
    ..The KCNQ1 (Kv7.1) channel plays an important role in cardiovascular physiology. Cardiomyocytes co-express KCNQ1 with KCNE1-5 proteins...
  43. doi Structural basis of slow activation gating in the cardiac I Ks channel complex
    Nathalie Strutz-Seebohm
    Department of Biochemistry I Cation Channel Group, Ruhr University, Bochum, Germany
    Cell Physiol Biochem 27:443-52. 2011
    ..Among the most dramatic changes of biophysical properties of a voltage-gated channel by KCNEs are the effects of KCNE1 on KCNQ1 channels. KCNQ1 and KCNE1 are believed to form nativeI(Ks) channels...
  44. doi [Association of rs1805127 polymorphism of KCNE1 gene with atrial fibrillation in Uigur population of Xinjiang]
    Juan Yao
    Department of Cardiology, The First Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang 830054, P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 28:436-40. 2011
    To investigate the association between the polymorphism of potassium voltage-gated channel, Isk-related family, member 1 (KCNE1) gene and atrial fibrillation (AF) in Uigur patients of Xinjiang.
  45. pmc IKs channels open slowly because KCNE1 accessory subunits slow the movement of S4 voltage sensors in KCNQ1 pore-forming subunits
    Katarina J Ruscic
    Department of Biochemistry, Brandeis University, Waltham, MA 02454, USA
    Proc Natl Acad Sci U S A 110:E559-66. 2013
    ..I(Ks) channels are composed of KCNQ1 (Q1) pore-forming subunits that carry S4 voltage-sensor segments and KCNE1 (E1) accessory subunits. Together, Q1 and E1 subunits recapitulate the conductive and kinetic properties of I(Ks)...
  46. ncbi Polymorphism of the gene encoding a human minimal potassium ion channel (minK)
    L P Lai
    Department of Medicine, University of Rochester Medical Center, NY 14642
    Gene 151:339-40. 1994
    A gene (minK) that encodes a minimal potassium channel has been cloned recently. We describe in this paper a human minK sequence which differs from the original sequence with a single A-->G at position 112...
  47. ncbi Exclusion of KCNE1 (IsK) as a candidate gene for Jervell and Lange-Nielsen syndrome
    F Tesson
    INSERM UR153, Hopital Pitie Salpetriere, Institut de Myologie, Paris, France
    J Mol Cell Cardiol 28:2051-5. 1996
    The KCNE1 gene encodes a small protein, IsK, of 14.4 kDa, with a single transmembrane domain, and is part of a potassium channel expressed in the heart...
  48. ncbi IsK and KvLQT1: mutation in either of the two subunits of the slow component of the delayed rectifier potassium channel can cause Jervell and Lange-Nielsen syndrome
    J Tyson
    Unit of Clinical Genetics, Institute of Child Health and Great Ormond Street Hospital for Children NHS Trust, UCL Medical School, 30 Guilford Street, London WC1N 1EH, UK
    Hum Mol Genet 6:2179-85. 1997
    The Jervell and Lange-Nielsen syndrome (JLNS) comprises profound congenital sensorineural deafness associated with syncopal episodes...
  49. ncbi KCNE1 mutations cause jervell and Lange-Nielsen syndrome
    E Schulze-Bahr
    Nat Genet 17:267-8. 1997
  50. ncbi A novel long-QT 5 gene mutation in the C-terminus (V109I) is associated with a mild phenotype
    E Schulze-Bahr
    Institute for Arteriosclerosis Research, University of Munster, Molecular Cardiology, Domagkstrasse 3, 48149 Munster, Germany
    J Mol Med (Berl) 79:504-9. 2001
    Mutations in the human minK gene KCNE1 have been linked to autosomal dominant and autosomal recessive long-QT (LQT) syndrome, a cardiac condition predisposing to ventricular arrhythmias...
  51. ncbi Genetic variations of KCNQ1, KCNH2, SCN5A, KCNE1, and KCNE2 in drug-induced long QT syndrome patients
    Aimee D C Paulussen
    Department of Pharmacogenomics, Johnson and Johnson Pharmaceutical Research and Development, Turnhoutseweg 30, Beerse, Belgium
    J Mol Med (Berl) 82:182-8. 2004
    ..Five cLQTS genes ( KCNH2, KCNQ1, SCN5A, KCNE1, KCNE2) were thoroughly screened for genetic variations in 32 drug-induced aLQTS patients with confirmed TdP and ..
  52. ncbi Association of KCNQ1, KCNE1, KCNH2 and SCN5A polymorphisms with QTc interval length in a healthy population
    Laetitia Gouas
    INSERM U582, Institut de Myologie, IFR 14, UPMC, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Eur J Hum Genet 13:1213-22. 2005
    ..T (D1819D) minor alleles were significantly more frequent in the group with the shortest QTc interval, whereas KCNE1 253 A (D85N), SCN5A 1673 G (H558R) and 1141-3 A minor alleles were significantly more frequent in the group with ..
  53. ncbi Possible association of the human KCNE1 (minK) gene and QT interval in healthy subjects: evidence from association and linkage analyses in Israeli families
    Y Friedlander
    Unit of Epidemiology, Hebrew University Hadassah School of Public Health, POB 12272, Jerusalem 91120, Israel
    Ann Hum Genet 69:645-56. 2005
    ..Using linkage and association analyses, we investigated whether variants in the potassium channel subunit KCNE1 are associated with QTc intervals in an unselected population sample of 80 kindreds living in kibbutz settlements ..
  54. ncbi The contribution of genes involved in potassium-recycling in the inner ear to noise-induced hearing loss
    Lut Van Laer
    Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
    Hum Mutat 27:786-95. 2006
    ..susceptible and resistant individuals for the allele, genotype, and haplotype frequencies for three SNPs of the KCNE1 gene, and for the allele frequencies for one SNP of KCNQ1 and one SNP of KCNQ4...
  55. ncbi Characterization of the cardiac KCNE1 gene promoter
    Zenab Mustapha
    Research Center and Department of Medicine, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    Cardiovasc Res 73:82-91. 2007
    b>KCNE1 encodes an essential cardiac slow delayed-rectifier potassium current (I(Ks)) beta-subunit (minK). Varying minK expression is important in disease-related remodeling and species-dependent expression...
  56. ncbi N- and C-terminal KCNE1 mutations cause distinct phenotypes of long QT syndrome
    Seiko Ohno
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Heart Rhythm 4:332-40. 2007
    ..The MinK protein is a cardiac K-channel accessory subunit encoded by the KCNE1 gene, mutations of which are associated with the LQT5 form of LQTS.
  57. pmc Serial perturbation of MinK in IKs implies an alpha-helical transmembrane span traversing the channel corpus
    Haijun Chen
    The Department of Pediatrics and Institute for Molecular Pediatric Sciences, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, USA
    Biophys J 93:2332-40. 2007
    I(Ks) channels contain four pore-forming KCNQ1 subunits and two accessory MinK subunits...
  58. pmc KCNE peptides differently affect voltage sensor equilibrium and equilibration rates in KCNQ1 K+ channels
    Jessica M Rocheleau
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts, Worcester, MA 01605, USA
    J Gen Physiol 131:59-68. 2008
    ..KCNQ1/KCNE1 complexes generate the very slowly activating cardiac I(Ks) current, whereas assembly with KCNE3 produces a ..
  59. pmc KCNQ1 and KCNE1 in the IKs channel complex make state-dependent contacts in their extracellular domains
    Xulin Xu
    Department of Physiology and Biophysics, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
    J Gen Physiol 131:589-603. 2008
    KCNQ1 and KCNE1 (Q1 and E1) associate to form the slow delayed rectifier I(Ks) channels in the heart...
  60. doi Effect of common KCNE1 and SCN5A ion channel gene variants on T-wave alternans, a marker of cardiac repolarization, during clinical exercise stress test: the Finnish Cardiovascular Study
    Jenni Koskela
    Department of Internal Medicine, Tampere University Hospital and Medical School at the University of Tampere, Tampere, Finland
    Transl Res 152:49-58. 2008
    ..We examined the effect of 3 ion channel gene single nucleotide polymorphisms (SNPs), rs1805127, rs727957 KCNE1, and rs1805124 SCN5A, on TWA during a clinical exercise test...
  61. pmc Intracellular domains interactions and gated motions of I(KS) potassium channel subunits
    Yoni Haitin
    Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    EMBO J 28:1994-2005. 2009
    ..In heart, assembly of Kv7.1 pore-forming subunits with KCNE1 beta subunits generates the repolarizing K(+) current I(KS)...
  62. doi D85N, a KCNE1 polymorphism, is a disease-causing gene variant in long QT syndrome
    Yukiko Nishio
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Am Coll Cardiol 54:812-9. 2009
    This study aims to address whether D85N, a KCNE1 polymorphism, is a gene variant that causes long QT syndrome (LQTS) phenotype.
  63. pmc Analysis of the interactions between the C-terminal cytoplasmic domains of KCNQ1 and KCNE1 channel subunits
    Renjian Zheng
    Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Biochem J 428:75-84. 2010
    Ion channel subunits encoded by KCNQ1 and KCNE1 produce the slowly activating K+ current (IKs) that plays a central role in myocardial repolarization...
  64. pmc KCNE1 alters the voltage sensor movements necessary to open the KCNQ1 channel gate
    Jeremiah D Osteen
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 107:22710-5. 2010
    The delayed rectifier I(Ks) potassium channel, formed by coassembly of α- (KCNQ1) and β- (KCNE1) subunits, is essential for cardiac function...
  65. pmc Association of KCNE1 genetic polymorphisms with atrial fibrillation in a Chinese Han population
    Juan Yao
    Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, P R China
    Genet Test Mol Biomarkers 16:1343-6. 2012
    The purpose of this study was to investigate the association of the polymorphisms of the KCNE1 gene with atrial fibrillation (AF) in a Chinese Han population.
  66. ncbi Expression and transcriptional control of human KCNE genes
    Andrew L Lundquist
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Genomics 87:119-28. 2006
    ..The KCNE genes (KCNE1-5) encode a family of single-transmembrane-domain proteins that modulate the properties of several potassium ..
  67. ncbi Genetic testing in the long QT syndrome: development and validation of an efficient approach to genotyping in clinical practice
    Carlo Napolitano
    Molecular Cardiology, IRCCS Fondazione S Maugeri Foundation, Pavia, Italy
    JAMA 294:2975-80. 2005
    ..In long QT syndrome (LQTS), disease severity and response to therapy vary according to the genetic loci. There exists a critical need to devise strategies to expedite genetic analysis...
  68. ncbi The common non-synonymous variant G38S of the KCNE1-(minK)-gene is not associated to QT interval in Central European Caucasians: results from the KORA study
    Mahmut Akyol
    Institute of Human Genetics, GSF National Research Centre of Environment and Health, Ingolstadter Landstr 1, D 85764 Neuherberg, Germany
    Eur Heart J 28:305-9. 2007
    ..an association between QT interval and the common non-synonymous Glycin 38 Serine variant (G38S, rs1805127) of the KCNE1 gene coding for the minK-potassium channel subunit...
  69. ncbi Mutations in the hminK gene cause long QT syndrome and suppress IKs function
    I Splawski
    Department of Human Genetics, University of Utah, Salt Lake City 84112, USA
    Nat Genet 17:338-40. 1997
    ..Recent physiological studies suggest that KCNE1 encodes beta-subunits (hminK) that co-assemble with KvLQT1 alpha-subunits to form the slowly activating delayed ..
  70. ncbi An LQT mutant minK alters KvLQT1 trafficking
    Andrew Krumerman
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Am J Physiol Cell Physiol 286:C1453-63. 2004
    ..Mutations of genes encoding KvLQT1 and minK are responsible for the hereditary long QT syndrome (loci LQT1 and LQT5, respectively). MinK-L51H fails to traffic to the cell surface, thereby failing to produce effective I(Ks)...
  71. ncbi Compound mutations: a common cause of severe long-QT syndrome
    Peter Westenskow
    Department of Physiology, University of Utah, 95 South 2000 East, Salt Lake City, UT 84112 5000, USA
    Circulation 109:1834-41. 2004
    ..Although most LQTS individuals do not have cardiac events, significant phenotypic variability exists within families. Probands can be very symptomatic. The mechanism of this phenotypic variability is not understood...
  72. ncbi [Present concepts of congenital long QT syndrome]
    A Leenhardt
    Service de cardiologie, , Paris
    Arch Mal Coeur Vaiss 93:17-21. 2000
    ..the a subunit of the sodium channel INa (SCN5A for LQT3), and two regulatory subunits of potassium channels (KCNE1 for LQT5 regulating the KvLQT1 channel and MiRP1 regulating HERG)...
  73. pmc Gating and flickery block differentially affected by rubidium in homomeric KCNQ1 and heteromeric KCNQ1/KCNE1 potassium channels
    M Pusch
    Istituto di Cibernetica e Biofisica, Consiglio Nazionale della Ricerche, Via De Marini 6, I 16149 Genova, Italy
    Biophys J 78:211-26. 2000
    The voltage-gated potassium channel KCNQ1 associates with the small KCNE1 subunit to form the cardiac IKs delayed rectifier potassium current and mutations in both genes can lead to the long QT syndrome...
  74. pmc Ancillary subunits and stimulation frequency determine the potency of chromanol 293B block of the KCNQ1 potassium channel
    Glenna C L Bett
    Department of Gynecology and Obstetrics, Department of Physiology and Biophysics, 124 Sherman Hall, State University of NY at Buffalo, Buffalo, NY 14214, USA
    J Physiol 576:755-67. 2006
    ..In heart, KCNQ1 associates with KCNE1 (MinK), producing a slowly activating voltage-dependent channel...
  75. pmc The relationship between capsid protein (VP2) sequence and pathogenicity of Aleutian mink disease parvovirus (ADV): a possible role for raccoons in the transmission of ADV infections
    K L Oie
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840, USA
    J Virol 70:852-61. 1996
    Aleutian mink disease parvovirus (ADV) DNA was identified by PCR in samples from mink and raccoons on commercial ranches during an outbreak of Aleutian disease (AD)...
  76. ncbi Spontaneous mutation of cell oncogenes plays a minor role in neoplastic transformation of virus-induced murine T-cell lymphomas
    D Gasparotto
    Department of Experimental Oncology 1, Centro di Riferimento Oncologico, Aviano (PN, Italy
    Tumori 81:268-72. 1995
    b>Mink cell focus-forming viruses (MCF) are slow-transforming retroviruses that are able to accelerate the appearance of T-cell lymphomas when injected in newborn AKR mice...
  77. pmc Comparison of promoter activity in Aleutian mink disease parvovirus, minute virus of mice, and canine parvovirus: possible role of weak promoters in the pathogenesis of Aleutian mink disease parvovirus infection
    J Christensen
    Department of Veterinary Microbiology, Royal Veterinary and Agricultural University of Copenhagen, Frederiksberg, Denmark
    J Virol 67:1877-86. 1993
    Aleutian mink disease parvovirus (ADV) infection causes both acute and chronic disease in mink, and we have previously shown that it is the level of viral gene expression that determines the disease pattern...
  78. pmc Expression of Aleutian mink disease parvovirus capsid proteins in defined segments: localization of immunoreactive sites and neutralizing epitopes to specific regions
    M E Bloom
    Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Disease, Hamilton, Montana 59840, USA
    J Virol 71:705-14. 1997
    The capsid proteins of the ADV-G isolate of Aleutian mink disease parvovirus (ADV) were expressed in 10 nonoverlapping segments as fusions with maltose-binding protein in pMAL-C2 (pVP1, pVP2a through pVP2i)...
  79. pmc S-phase-dependent cell cycle disturbances caused by Aleutian mink disease parvovirus
    M B Oleksiewicz
    Department of Pharmacology and Pathobiology, Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    J Virol 71:1386-96. 1997
    We examined replication of the autonomous parvovirus Aleutian mink disease parvovirus (ADV) in relation to cell cycle progression of permissive Crandell feline kidney (CRFK) cells...
  80. pmc Identification of a novel KCNQ1 mutation associated with both Jervell and Lange-Nielsen and Romano-Ward forms of long QT syndrome in a Chinese family
    Su Zhang
    Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, PR China
    BMC Med Genet 9:24. 2008
    ..two inherited forms of LQTS have been defined: autosomal dominant LQTS or Romano-Ward syndrome (RWS) not associated with deafness and autosomal recessive LQTS or Jervell and Lange-Nielsen syndrome (JLNS) associated with deafness.
  81. ncbi Carnivora: the amino acid sequence of the adult European mink (Mustela lutreola, Mustelidae) hemoglobins
    A Ahmed
    , Abteilung Proteinchemie, , Bundersrepublik Deutschland
    Z Naturforsch C 45:223-8. 1990
    The complete amino acid sequences of the hemoglobins from the adult European mink (Mustela lutreola) are presented. The erythrocytes contain two hemoglobin components and three globin chains...
  82. ncbi Effect of dietary glycine and benzoate level on benzoate metabolism in mink (Mustela vision), blue fox (Alopex lagopus), and raccoon dog (Nyctereutes procyonoides)
    I J Pölönen
    Finnish Fur Breeders Association, Vantaa
    J Anim Sci 78:976-86. 2000
    Three 2 x 4 factorial experiments were carried out from August to September with 30 juvenile male mink, 24 raccoon dogs, and 24 blue foxes to investigate the effect of dietary glycine supply (low or high) on the efficiency of these ..
  83. pmc Aleutian mink disease parvovirus infection of mink peritoneal macrophages and human macrophage cell lines
    H Kanno
    Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, Montana 59840
    J Virol 67:2075-82. 1993
    Aleutian mink disease parvovirus (ADV) mRNAs are found in macrophages in lymph nodes and peritoneal exudate cells from ADV-infected mink...
  84. pmc Aleutian mink disease parvovirus infection of mink macrophages and human macrophage cell line U937: demonstration of antibody-dependent enhancement of infection
    H Kanno
    Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, Montana 59840
    J Virol 67:7017-24. 1993
    Aleutian mink disease parvovirus (ADV) infects macrophages in adult mink...
  85. ncbi Pathogenesis of disease caused by Aleutian mink disease parvovirus
    S Alexandersen
    Department of Veterinary Pathology, Royal Veterinary and Agricultural University, Copenhagen, Denmark
    APMIS Suppl 14:1-32. 1990
    A review of the pathogenesis of Aleutian mink disease parvovirus (ADV) infection based on recent knowledge gained by the author and collaborators is given. The review focuses mainly on the following topics...
  86. pmc Pathogenesis of Aleutian mink disease parvovirus infection: effects of suppression of antibody response on viral mRNA levels and on development of acute disease
    S Alexandersen
    Department of Pharmacology and Pathobiology, Royal Veterinary and Agricultural University of Copenhagen, Frederiksberg C, Denmark
    J Virol 68:738-49. 1994
    We suppressed the B-cell development and antibody response in mink by using treatment with polyclonal anti-immunoglobulin M (anti-IgM) to study the effects of antiviral antibodies on development of Aleutian mink disease parvovirus (ADV)-..
  87. pmc Replacement of interleukin-2 (IL-2)-generated mitogenic signals by a mink cell focus-forming (MCF) or xenotropic virus-induced IL-9-dependent autocrine loop: implications for MCF virus-induced leukemogenesis
    M M Flubacher
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111
    J Virol 68:7709-16. 1994
    ..IL-2)-dependent, Moloney murine leukemia virus (MoMuLV)-induced rat T-cell lymphoma line (4437A) with mink cell focus-forming (also called polytropic) murine retroviruses induces rapid progression to IL-2-independent ..
  88. ncbi Leptospirosis in free-ranging endangered European mink (Mustela lutreola) and other small carnivores (Mustelidae, Viverridae) from southwestern France
    Marie Moinet
    Groupe de Recherche et d Etude pour la Gestion de l Environnement, route de Préchac, 33730 Villandraut, France
    J Wildl Dis 46:1141-51. 2010
    To study the possible role of disease in the decline of endangered European mink (Mustela lutreola), we conducted a survey of antibody prevalence and renal carriage of pathogenic leptospira (Leptospira interrogans sensu lato) using serum ..
  89. ncbi Pathogenesis of aleutian mink disease parvovirus and similarities to b19 infection
    S M Best
    Laboratory of Persistent Viral Diseases, NIAID, NIH Rocky Mountain Laboratories, 903 S Fourth St, Hamilton, MT 59840, USA
    J Vet Med B Infect Dis Vet Public Health 52:331-4. 2005
    Aleutian mink disease parvovirus (ADV) is an unusual member of the autonomous parvoviruses in both its replication and pathogenesis...
  90. pmc cis-acting sequences in the Aleutian mink disease parvovirus late promoter important for transcription: comparison to the canine parvovirus and minute virus of mice
    T Storgaard
    Department of Pharmacology and Pathobiology, University of Copenhagen, Frederiksberg, Denmark
    J Virol 67:1887-95. 1993
    We are currently investigating the regulation of transcription of the Aleutian mink disease parvovirus (ADV)...
  91. pmc Mechanisms of ventricular arrhythmogenesis in mice following targeted disruption of KCNE1 modelling long QT syndrome 5
    Glyn Thomas
    Section of Cardiovascular Biology, Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK
    J Physiol 578:99-114. 2007
    Mutations within KCNE1 encoding a transmembrane protein which coassembles with K+ channels mediating slow K+, I(Ks), currents are implicated in cardiac action potential prolongation and ventricular arrhythmogenicity in long QT syndrome 5...
  92. ncbi Analysis of parvovirus infections using strand-specific hybridization probes
    M E Bloom
    Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana
    Virus Res 14:1-25. 1989
    ..Strand-specific RNA hybridization probes were developed for the Aleutian mink disease parvovirus (ADV) and were used to study acute and chronic infections of mink...
  93. ncbi Comparisons of feline panleukopenia virus, canine parvovirus, raccoon parvovirus, and mink enteritis virus and their pathogenicity for mink and ferrets
    C R Parrish
    James A Baker Institute for Animal Health, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853
    Am J Vet Res 48:1429-35. 1987
    Parvoviruses from mink (mink enteritis virus [MEV]), cats (feline panleukopenia virus [FPV]), raccoons (raccoon parvovirus [RPV]), and dogs (canine parvovirus [CPV]) were compared...
  94. pmc Duplication of U3 sequences in the long terminal repeat of mink cell focus-inducing viruses generates redundancies of transcription factor binding sites important for the induction of thymomas
    Nancy L DiFronzo
    Center for Virology and Immunology Research, Children s Research Institute, George Washington University School of Medical and Health Sciences, Washington, DC 20010, USA
    J Virol 77:3326-33. 2003
    The ability of mink cell focus-inducing (MCF) viruses to induce thymomas is determined, in part, by transcriptional enhancers in the U3 region of their long terminal repeats (LTRs)...
  95. pmc Two parvoviruses that cause different diseases in mink have different transcription patterns: transcription analysis of mink enteritis virus and Aleutian mink disease parvovirus in the same cell line
    T Storgaard
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840, USA
    J Virol 71:4990-6. 1997
    The two parvoviruses of mink cause very different diseases. Mink enteritis virus (MEV) is associated with rapid, high-level viral replication and acute disease...
  96. ncbi Effects of Aroclor 1242 and different fish-based diets on vitamins A1 (retinol) and A2 (3,4-didehydroretinol), and their fatty acyl esters in mink plasma
    Anne Käkelä
    Department of Biology, University of Joensuu, P O Box 111, FIN 80101 Joensuu, Finland
    Environ Res 91:104-12. 2003
    ..A(1)-18:1n-9; A(2)-18:1n-9 (oleates), and A(1)-18:0; A(2)-18:0 (stearates)) were studied in young female mink (Mustela vison) fed a diet based on freshwater smelt...
  97. pmc Radiographic evaluation of destructive periodontal disease in blue mink in relation to age and blood morphology
    Anne Sofie Hammer
    Danish Institute for Food and Veterinary Research, 2 Hangoevej, DK 8200 Aarhus, Denmark
    Can J Vet Res 69:128-34. 2005
    In this study, blood samples and jaws were collected from 2 genotypes of blue mink (n = 289) in order to examine phenotypic expression of specific characteristics of Chediak-Higashi Syndrome (C-HS)...
  98. pmc Cytokine profiles in adult mink infected with Aleutian mink disease parvovirus
    P V Jensen
    Laboratory of Virology and Immunology, Department of Veterinary Microbiology, The Royal Veterinary and Agricultural University, 1870 Frederiksberg C, Copenhagen, Denmark
    J Virol 77:7444-51. 2003
    ..interferon (IFN-gamma)-, interleukin 4 (IL-4)-, and IL-8-producing cells in peripheral blood mononuclear cells from mink infected with the Aleutian mink disease parvovirus (ADV)...
  99. ncbi Aleutian mink disease: puzzles and paradigms
    M E Bloom
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840
    Infect Agents Dis 3:279-301. 1994
    Aleutian mink disease (AD) is a naturally occurring persistent virus infection of mink caused by the Aleutian mink disease parvovirus (ADV)...
  100. pmc Identification of a cell surface protein from Crandell feline kidney cells that specifically binds Aleutian mink disease parvovirus
    J M Fox
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Virol 73:3835-42. 1999
    Aleutian mink disease parvovirus (ADV) is the etiological agent of Aleutian disease of mink. The acute disease caused by ADV consists of permissive infection of alveolar type II cells that results in interstitial pneumonitis...
  101. pmc A novel mutation in KCNQ1 associated with a potent dominant negative effect as the basis for the LQT1 form of the long QT syndrome
    Yoshiyasu Aizawa
    Masonic Medical Research Laboratory, Utica, New York 13501 1787, USA
    J Cardiovasc Electrophysiol 18:972-7. 2007
    ..Long QT Syndrome (LQTS) is an inherited disorder characterized by prolonged QT intervals and life-threatening polymorphic ventricular tachyarrhythmias. LQT1 caused by KCNQ1 mutations is the most common form of LQTS...

Research Grants75

  1. Structural Analysis of Voltage-gated Potassium Channels
    ROBERT BLAUSTEIN; Fiscal Year: 2006
    ..Shaker channel, and heteromultimeric channels formed from the co-assembly of Shaker-like subunits with minK-related peptides (MiRPs)...
  2. MOLECULAR DETERMINANTS OF POTASSIUM CHANNEL DRUG BLOCK
    Dirk Snyders; Fiscal Year: 2003
    ..molecular architecture of the channel protein complex includes function-altering accessory subunits (beta subunits, minK) which may impact on drug binding...
  3. Role of KVS and MPS Subunits in Basic Neuronal Function
    Federico Sesti; Fiscal Year: 2007
    ..elegans nervous system. In addition we cloned mps-1, the first C. elegans MiRP. MinK Related Peptides (MiRPs) are small transmembrane proteins that associate with K+ channels to alter their function...
  4. Towards the Physiologic Function of MiRP-3
    Daniel I Levy; Fiscal Year: 2010
    ..This application describes the study of the beta subunit MiRP-3, a novel member of the MinK-related peptide superfamily, which can modulate the properties of such K+ channels...
  5. INTERCELLULAR COMMUNICATION AND IMPULSE PROPAGATION
    JOSE S JALIFE; Fiscal Year: 2010
    ..1 (KCNJ2) and the delayed rectifier HERG (KCHN2) and KyLQT1 (KCNQ1)/mink (KCNE1) modify the ability of cardiac electrical waves to propagate through non-homogeneous cardiac muscle during complex ..
  6. Geoffrey W Abbott; Fiscal Year: 2015
    ..2 (Ito,f) and, unexpectedly, Kv1.5 (IK,slow1). We also defined a new role for KCNE1, as an endocytic chaperone of the KCNQ1 a subunit, and found that both KCNE1 and KCNE2 can influence the a subunit ..
  7. MOLECULAR BASIS FOR DRUG INDUCED CARDIOTOXICITY IN AIDS
    CRAIG CLARKSON; Fiscal Year: 2001
    ..l, Kvl.4, Kvl.5, Kv2.l, minK, Kv4.3, HIRK, HERG, and the beta subunits of Kvl.2 and Kv2. 7) The hypothesis that Kv4.2 and/or Kv4...
  8. TARGETING HERG: A MOUSE MODEL OF THE LONG QT SYNDROME
    Barry London; Fiscal Year: 2002
    ..HERG subunits interact in-vitro with IsK (minK), a K+ channel beta-subunit that coassembles with KvLQT1 to form the cardiac current IKs...
  9. Neural Interactions Among Multiple Motor Structures
    Marc H Schieber; Fiscal Year: 2010
    ..Project 4, Basal Ganglia - Cortical Interactions in Motor Control (Mink, PI) asks how interactions of the globus pallidus, pars interna, with the primary motor cortex and the ..
  10. TRANSCRIPTIONAL CONTROL OF MAMMALIAN BRAIN DEVELOPMENT
    Eseng Lai; Fiscal Year: 2001
    ..hypothesis that BF-1 regulates cell cycle and thus controls number of neurons in telencephalon and as assayed in Mink cell culture system...
  11. Steve A N Goldstein; Fiscal Year: 2015
    ..Also called MinK-related peptides (MiRPs), these single-pass transmembrane accessory subunits merit investigation because they are ..
  12. MOLECULAR ENGINEERING OF RETROVIRAL VACCINES
    Edward Stephens; Fiscal Year: 1990
    ..different recombinant vaccinia viruses expressing either intact or secreted forms of the gp70/p15E of F-MuLV and mink cell focus forming virus (F- MCFV)...
  13. 5th International Scientific Symposium on Tourette Syndrome
    Kevin Black; Fiscal Year: 2009
    ..The Symposium Co-chairs are Peter Hollenbeck PhD, Jonathan Mink MD PhD, and John Walkup MD, who (as is appropriate for this disorder) collectively represent basic science, child ..
  14. Mutations of the type 1 TGF beta receptor in cancer
    Boris Pasche; Fiscal Year: 2002
    ..Stable transfection of mink lung epitheliall cell lines devoid of TbR-I with either TbR-I or TbR-I(6A) shows that TbR-l(6A) transduces less ..
  15. BLOCK OF MYOCARDIAL ION CHANNELS BY ANTIMALARIAL DRUGS
    Michael Sanguinetti; Fiscal Year: 2002
    ..myocytes; and 3) determine the mechanism of block by antimalarial drugs of cloned human K+ channels (HERG, KvLQT1/minK, HIRK1) expressed in Xenopus oocytes...
  16. FKBP12 IN TGF-BETA TYPE I RECEPTOR MEDIATED SIGNALING
    Tongwen Wang; Fiscal Year: 1999
    ..the interaction has now been confirmed in yeast, in vitro and most recently in mammalian cell lines such as COS and mink Mv1Lu cells...
  17. CELLULAR IMMUNITY TO ENDOGENOUS AKR LEUKEMIA VIRUSES
    William Green; Fiscal Year: 1993
    ..leukemia viruses (MuLV); to determine whether it is possible to generate CTL that are specific for recombinant mink cell focus-inducing (MCF) MuLV and if so, to characterize these MCF MuLV directed CTL and define their molecular ..
  18. VARIATION, IMMUNE ESCAPE, AND PATHOGENESIS OF MULV
    William Green; Fiscal Year: 2000
    ..Although the proximal leukemogenic MuLV are recombinant mink cell cytopathic focus-inducing (MCF) retroviruses generated at several months of age, the early-arising ecotropic ..
  19. CALMODULIN KINASE II AND EARLY AFTER DEPOLARIZATIONS
    Mark Anderson; Fiscal Year: 2001
    ..Cardiac cells from a recently engineered MinK gene knock out mouse, will also be available for these studies. This study will take place under the guidance of Dr...
  20. Molecular Physiology of Human Renal CIC-K Channels
    CARLOS VANOYE; Fiscal Year: 2004
    ..made the remarkable discovery that co-expression of CIC-Kb with the previously recognized K plus channel subunit KCNE1 (minK) leads to functional Cl- channels in a heterologous mammalian cell system...
  21. MinK-related peptides(MiRPs): structure and function
    Steve Goldstein; Fiscal Year: 2004
    DESCRIPTION: MinK is a small ion channel subunit with a single transmembrane span. It is active only after assembly with a pore-forming subunit. Nonetheless, MinK is required for normal channel function in some tissues...
  22. MEMBRANE CURRENTS IN CARDIAC MUSCLE
    Arthur Brown; Fiscal Year: 2003
    ..and may be useful as a chaperone to rescue misprocessed mutants; and 4) study the interactions between KvLQT1 and minK during processing using misprocessed mutants linked to hereditary long QT syndrome (hLQTS) as probes...
  23. CARDIAC POTASSIUM CHANNEL SUBUNITS AND SUDDEN DEATH
    Martin Tristani Firouzi; Fiscal Year: 2002
    ..KvLQT1 proteins coassemble with a regulatory subunit, minK, to form the slowly activating cardiac delayed rectifier (Iks) channel...
  24. Identification and characterization of molecules important in the immune system
    Nami McCarty; Fiscal Year: 2007
    ..unreadable] With these combined genomic and RNAi-based methodologies I identified and characterized MINK [unreadable] (Misshapen-NIK-related kinase), which is important for negative selection in the thymus...
  25. Mouse Models to Study MiRP3 Physiology
    Daniel Levy; Fiscal Year: 2009
    ..This application describes the study of the beta subunit MiRP3, a novel member of the MinK-related peptide superfamily, which can modulate the properties of such K+ channels...
  26. Gene Targets of NKX 2.5 in the Conduction System
    Melvin Scheinman; Fiscal Year: 2004
    ..Finally, we plan to study the role of specific ion channels (i.e. MinK and HCN-1) in the pathogenesis of arrhythmias in the ventricular restricted knockout mouse model...
  27. Carlos G Vanoye; Fiscal Year: 2014
    ..The human KCNQ1 voltage-gated potassium channel is modulated by interactions with an accessory subunit, KCNE1, a process that is essential for healthy cardiac and auditory function...
  28. Coeli M B Lopes; Fiscal Year: 2016
    ..propose that sustained cPKC activation leads to decrease in IKs via the channel internalization controlled by cPKC-KCNE1(S102) pathway underlying an increase in action potential duration (APD) and calcium overload, setting the stage ..
  29. Screening for Jervell and Lange-Nielsen Syndrome
    Ruey Kang R Chang; Fiscal Year: 2010
    ..The Jervell and Lange-Nielsen syndrome (JLNS) is the most severe form of LQTS, with a hallmark feature of congenital sensorineural hearing loss (SNHL)...
  30. William R Kobertz; Fiscal Year: 2014
    ..calmodulin bound to peptides, we will generate quaternary structures of the differently calcified KCNQ4- and KCNQ1/KCNE1-calmodulin complexes...
  31. Gary A Lorigan; Fiscal Year: 2016
    ..The overall goals of this proposal are (1) investigate the structure and topology of the membrane-bound KCNE1 protein;(2) elucidate the binding mechanism of KCNE1 with the C-terminal domain of the KCNQ1 K+ channel;(3) ..
  32. MULTI-ANALYTE WAVEGUIDE IMMUNOSENSING
    JAMES HERRON; Fiscal Year: 2002
    ..LQTS has been linked to genetic polymorphisms in four genes (KVLQT1,HERG, SCN5A & KCNE1) that encode for cardiac ion channels...
  33. Functions and Disorders of K Channels in the Ineer Ear
    Tsung Yu Chen; Fiscal Year: 2012
    ..by the fact that mutations of KCNQ channels results in deafness in humans as seen in Jervell Lang Nielson syndrome (JLNS), and an autosomal dominant form of nonsyndromic progressive hearing loss (PHL: DFNA2)...
  34. Marian T Hannan; Fiscal Year: 2015
    ..We hypothesize these factors predict hip fracture, and further that the factor-of-risk prediction of hip fracture isk will prove better than BMD assessment alone and better than the World Health Organization FRAX tool...
  35. MOLECULAR BASIS FOR Kv CHANNEL HETEROGENEITY IN THE HEART
    Gea Ny Tseng; Fiscal Year: 2010
    ..The IKs channel consists of at least two components: KCNQ1 channel and KCNE1 auxiliary subunit...
  36. B Eugene Parker; Fiscal Year: 2014
    ..The fall risk assessment tool will furnish a universal algorithm for initializing, adapting, and optimizing fall isk assessments based on the patient risk factor data that are available in a given setting...
  37. Gea Ny Tseng; Fiscal Year: 2015
    ..IKs has 2 major components: pore-forming KCNQ1 channel and auxiliary KCNE1 subunits...
  38. DNA FORMS OF MURINE LEUKEMIA VIRUSES
    FAYTH YOSHIMURA; Fiscal Year: 2007
    ..In our studies of the early stages of thymic lymphoma development in mice, we demonstrated that infection by a mink cell focus-forming (MCF) MLV led to an enhancement of apoptosis of thymic lymphocytes...
  39. CYTOSOLIC REGULATION OF INNER EAR ION TRANSPORT
    A PHILINE WANGEMANN; Fiscal Year: 2007
    ..first, middle) The name of the principal investigator/program director must be provided at the top of each printed page and each continuation page RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page 1 Description, ..
  40. Mechanisms of prion transport
    RICHARD BESSEN; Fiscal Year: 2008
    ..These studies can determine the role of the olfactory nerve in centrifugal prion spread to the nasal mucosa where agent shedding is a potential route of prion transmission. ..
  41. STRAIN PROPERTIES OF THE PRION PROTEIN
    Jason Bartz; Fiscal Year: 2002
    ..For each of the aims, the hyper (HY) and drowsy (DY) strains of transmissible mink encephalopathy (TME) will be examined in order to determine the role of strain-specific PrP-res in the ..
  42. Novel Antagonists for Ameliorating Pulmonary Fibrosis
    JUNG HUANG; Fiscal Year: 2007
    ..The novel antagonists developed in this project should be ideal drug candidates for treating pulmonary fibrosis in humans. [unreadable] [unreadable] [unreadable]..
  43. The Genetic Basis of Atrial Fibrillation
    Patrick Ellinor; Fiscal Year: 2007
    ..Fishman. [] PHS 39812590 (Rev. 05101) Page % Continuation Format Page o Number pages consecutively at the bottom throughout the application. Do not use suffixes such as 3a, 3b. ..
  44. Regulation of Kv3.1 by MiRPs in Auditory Neurons
    GEOFFREY ABBOTT; Fiscal Year: 2006
    ..Further, MiRP2 and related subunits MinK and MiRP1 modify Kv3...
  45. Genetic Determinants of Sudden Cardiac Death
    Christine Albert; Fiscal Year: 2006
    ..Mutations in cardiac ion channel genes including SCN5A, KVLQT1, HERG, KCNE1, KCNE2, and RyR2 have been implicated in monogenic traits with a high risk of SCD, such as the Iong-QT, Brugada, ..
  46. Antigenic structure of adeno-associated virus capsids and antibody escape mutants
    Colin Parrish; Fiscal Year: 2008
    ..In this study we seek to define the antigenic structures if the viruses so that the adverse effects of antibodies on gene therapy trials can be better understood, and perhaps avoided in the future. [unreadable] [unreadable] [unreadable]..
  47. K+ channel protein complexes in auditory biology
    WILLIAM KOBERTZ; Fiscal Year: 2009
    ..The KCNQ1-KCNE1 K+ channel complex is the exclusive mechanism for endolymphatic K+ secretion into the cochlear duct...
  48. EXPRESSION AND PATHOGENESIS OF MURINE LEUKEMIA VIRUS
    Hung Fan; Fiscal Year: 2005
    ..low expression. Together, these experiments will provide new and important insights into leukemogenesis by MuLVs. ..
  49. Modifiable Determinants of Ventricular Arrythmias
    Christine Albert; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  50. MOLECULAR BIOLOGY OF JAAGSIEKTE SHEEP RETROVIRUS
    Hung Fan; Fiscal Year: 2003
    ..These experiments will provide insight into JSRV-induced lung cancer in sheep, and possibly into human BAC. ..
  51. Novel Therapeutic Agents for Diabetic Ulcers
    JUNG HUANG; Fiscal Year: 2008
    ..The novel antagonists developed in this project should be ideal drug candidates for treating diabetic foot ulcers in humans. [unreadable] [unreadable] [unreadable]..
  52. Molecular genetics of tame behavior
    ANNA KUKEKOVA; Fiscal Year: 2005
    ..A set of candidate genes implicated in human and/or rodent behavior will be evaluated for co segregation with tame and wild type behavioural phenotypes using existing and three-generation experimental fox pedigrees. ..
  53. MECHANISMS OF PARVOVIRUS INFECTION AND HOST RANGE
    Colin R Parrish; Fiscal Year: 2011
    ..We would seek to complement endosomal escape mutants in trans by adding adenovirus capsids, competent wild type parvovirus, or transferrin-PEI conjugates to the cells along with the parvoviruses. ..
  54. MECHANISMS OF REPOLARIZATION-INDUCED ARRHYTHMIAS
    Guy Salama; Fiscal Year: 2002
    ..abstract_text> ..
  55. MODIFIABLE RISK FACTORS FOR SUDDEN DEATH IN MEN/WOMEN
    Christine Albert; Fiscal Year: 2002
    ..At the end of the proposed research program, Dr. Albert will have attained advanced epidemiologic skills which can then be applied to independent research in her chosen subspecialty of electrophysiology. ..
  56. mTOR Signaling In Chronic Myelogenous Leukemia
    Hung Fan; Fiscal Year: 2009
    ..abstract_text> ..
  57. TRIGGERS OF VENTRICULAR ARRHYTHMIAS (TOVA) STUDY
    Christine Albert; Fiscal Year: 2002
    ..Characterization of triggering of ICD discharge will provide insights valuable for prevention of sudden death due to primary arrhythmias in the general population. ..
  58. CARDIAC K+ CHANNEL GENE INTERACTIONS AND ARRHYTHMIAS
    Thomas McDonald; Fiscal Year: 2001
    ..We have shown that HERG physically associates with another protein, minK, and that this association regulates IKr activity (7)...
  59. Molecular Mechanisms of Social Behavior
    Anna V Kukekova; Fiscal Year: 2010
    ....
  60. ROLES OF POLYPEPTIDE GROWTH FACTORS IN CELL GROWTH
    JUNG HUANG; Fiscal Year: 2004
    ....
  61. A Novel Immunotoxin for Treatment and Cure of Strabismus
    LEO CHALUPA; Fiscal Year: 2005
    ..The use of IX-146 could be extended in the future to a wider variety of ophthalmologic, neurologic, and neuromuscular disorders, including blepharospasm as well as other types of dystonias. ..
  62. Identification of compounds that protect HERG from block by proarrhythmic agents
    Sabina Kupershmidt; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  63. Molecular Basis of Automaticity in the Myometrium
    Glenna Bett; Fiscal Year: 2008
    ..Identification of an ion channel which is the uterine pacemaker offers the opportunity for designing interventions to prevent and delay preterm labor. [unreadable] [unreadable] [unreadable] [unreadable]..
  64. Gender-Differences in Cardiac Repolarization/Arrhythmias
    Guy Salama; Fiscal Year: 2005
    ..abstract_text> ..
  65. High-Speed, Depth-Resolved Images of Cardiac physiology
    Guy Salama; Fiscal Year: 2007
    ..We focus here on the heart because therein lie salient problems that are ready to be addressed by this new technology. However, the wide range of possible applications may lead to the commercialization of this new technology. ..
  66. Adrenergic Regulation of HERG Protein
    Thomas McDonald; Fiscal Year: 2007
    ..Specifically, we aim to: 1. Determine the significance of 14-3-3e and PKA regulation of HERG 2. Examine PKA targeting to HERG channels by AKAPs. 3. Examine PKA-mediated control of trafficking of HERG protein. ..
  67. Multidisciplinary Study of Right Ventricular Dysplasia
    Jeffrey Towbin; Fiscal Year: 2005
    ..This integrated research grant proposal offers a substantial prospect of expanding the fund of clinical knowledge regarding ARVD and of localizing the gene(s) responsible for this disorder. ..
  68. PARVOVIRUS STRUCTURE, CAPSID ASSEMBLY, AND RECEPTORS
    Colin Parrish; Fiscal Year: 2007
    ..abstract_text> ..
  69. Defective trafficking Mechanisms in a Cardiac K+ Channel
    Sabina Kupershmidt; Fiscal Year: 2006
    ..We will develop novel therapeutic strategies designed to correct intracellular processing steps of HERG and possibly other plasma membrane proteins that suffer from defects caused by the same mechanism. ..
  70. Factors that Initiate Arrhythamias in Long QT Syndrome
    Guy Salama; Fiscal Year: 2006
    ..Stimulation paradigms that i) enhance DOR or ii) elicit a bradycardia followed by a tachycardia are more likely to increase the incidence of EADs or TdP. ..