ITPA

Summary

Gene Symbol: ITPA
Description: inosine triphosphatase
Alias: C20orf37, HLC14-06-P, ITPase, My049, NTPase, dJ794I6.3, inosine triphosphate pyrophosphatase, inosine triphosphatase (nucleoside triphosphate pyrophosphatase), inosine triphosphate pyrophosphohydrolase, non-canonical purine NTP pyrophosphatase, non-standard purine NTP pyrophosphatase, nucleoside-triphosphate diphosphatase
Species: human

Top Publications

  1. ncbi House cleaning, a part of good housekeeping
    Michael Y Galperin
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    Mol Microbiol 59:5-19. 2006
  2. ncbi Cloning, expression, and characterization of a human inosine triphosphate pyrophosphatase encoded by the itpa gene
    S Lin
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai 200433, People s Republic of China
    J Biol Chem 276:18695-701. 2001
  3. ncbi Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency
    Satoshi Sumi
    Purine Research Unit, Department of Chemical Pathology, 5th Floor Thomas Guy House, Guy s and St Thomas Hospitals, London, SE1 9RT, UK
    Hum Genet 111:360-7. 2002
  4. ncbi Distribution of ITPA P32T alleles in multiple world populations
    Sharon Marsh
    Division of Oncology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8069, St Louis, MO 63110, USA
    J Hum Genet 49:579-81. 2004
  5. ncbi Pharmacogenetic association with adverse drug reactions to azathioprine immunosuppressive therapy following liver transplantation
    David P Breen
    College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, Scotland, UK
    Liver Transpl 11:826-33. 2005
  6. doi Thiopurine S-methyltransferase and inosine triphosphate pyrophosphohydrolase genes in Japanese patients with inflammatory bowel disease in whom adverse drug reactions were induced by azathioprine/6-mercaptopurine treatment
    Kan Uchiyama
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine Kashiwa Hospital, 163 1 Kashiwa shita, Kashiwa, Chiba, 277 8567, Japan
    J Gastroenterol 44:197-203. 2009
  7. pmc Functional study of the P32T ITPA variant associated with drug sensitivity in humans
    Elena I Stepchenkova
    Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, 68198 6805, USA
    J Mol Biol 392:602-13. 2009
  8. doi Association between inosine triphosphate pyrophosphohydrolase deficiency and azathioprine-related adverse drug reactions in the Chinese kidney transplant recipients
    Hui Xiong
    Department of Clinical Pharmacology, Wuhan General Hospital of Guangzhou Command, Wuhan 430070, China
    Fundam Clin Pharmacol 24:393-400. 2010
  9. pmc Quantitative in vitro and in vivo characterization of the human P32T mutant ITPase
    Greg Herting
    Department of Chemistry and Biochemistry, 226 Science Building, Eastern Washington University, Cheney, WA 99004, USA
    Biochim Biophys Acta 1802:269-74. 2010
  10. doi ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C
    Jacques Fellay
    Institute for Genome Sciences and Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina 27708, USA
    Nature 464:405-8. 2010

Research Grants

Detail Information

Publications169 found, 100 shown here

  1. ncbi House cleaning, a part of good housekeeping
    Michael Y Galperin
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    Mol Microbiol 59:5-19. 2006
    ..non-canonical NTPs belong to at least four structural superfamilies: MutT-related (Nudix) hydrolases, dUTPase, ITPase (Maf/HAM1) and all-alpha NTP pyrophosphatases (MazG)...
  2. ncbi Cloning, expression, and characterization of a human inosine triphosphate pyrophosphatase encoded by the itpa gene
    S Lin
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai 200433, People s Republic of China
    J Biol Chem 276:18695-701. 2001
    ..dITP is potentially mutagenic, and the levels of these nucleotides are controlled by inosine triphosphate pyrophosphatase (EC ). Here we report the cloning, expression, and characterization of a 21...
  3. ncbi Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency
    Satoshi Sumi
    Purine Research Unit, Department of Chemical Pathology, 5th Floor Thomas Guy House, Guy s and St Thomas Hospitals, London, SE1 9RT, UK
    Hum Genet 111:360-7. 2002
    b>Inosine triphosphate pyrophosphohydrolase (ITPase) deficiency is a common inherited condition characterized by the abnormal accumulation of inosine triphosphate (ITP) in erythrocytes...
  4. ncbi Distribution of ITPA P32T alleles in multiple world populations
    Sharon Marsh
    Division of Oncology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8069, St Louis, MO 63110, USA
    J Hum Genet 49:579-81. 2004
    ..Recently, a polymorphism in the inosine triphosphate pyrophosphatase gene (ITPA) has been associated with severe azathioprine toxicity...
  5. ncbi Pharmacogenetic association with adverse drug reactions to azathioprine immunosuppressive therapy following liver transplantation
    David P Breen
    College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, Scotland, UK
    Liver Transpl 11:826-33. 2005
    ..There is evidence that polymorphisms in the genes encoding thiopurine methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPase) predict adverse drug reactions to AZA therapy...
  6. doi Thiopurine S-methyltransferase and inosine triphosphate pyrophosphohydrolase genes in Japanese patients with inflammatory bowel disease in whom adverse drug reactions were induced by azathioprine/6-mercaptopurine treatment
    Kan Uchiyama
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine Kashiwa Hospital, 163 1 Kashiwa shita, Kashiwa, Chiba, 277 8567, Japan
    J Gastroenterol 44:197-203. 2009
    ..in the activities of the metabolizing enzymes thiopurine S-methyltransferase (TPMT) and inosine triphosphate pyrophosphohydrolase (ITPA)...
  7. pmc Functional study of the P32T ITPA variant associated with drug sensitivity in humans
    Elena I Stepchenkova
    Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, 68198 6805, USA
    J Mol Biol 392:602-13. 2009
    ..or 6-hydroxylaminopurine (HAP) deoxynucleoside triphosphate] into nucleic acids is prevented by inosine triphosphate pyrophosphatase (ITPA). The ITPA gene is a highly conserved, moderately expressed gene...
  8. doi Association between inosine triphosphate pyrophosphohydrolase deficiency and azathioprine-related adverse drug reactions in the Chinese kidney transplant recipients
    Hui Xiong
    Department of Clinical Pharmacology, Wuhan General Hospital of Guangzhou Command, Wuhan 430070, China
    Fundam Clin Pharmacol 24:393-400. 2010
    ..transplantation whether AZA-related side effects can be explained by the inosine triphophate pyrophosphatase (ITPA) or thiopurine S-methyltransferase (TPMT) polymorphisms using both pheno-and genotyping...
  9. pmc Quantitative in vitro and in vivo characterization of the human P32T mutant ITPase
    Greg Herting
    Department of Chemistry and Biochemistry, 226 Science Building, Eastern Washington University, Cheney, WA 99004, USA
    Biochim Biophys Acta 1802:269-74. 2010
    Human ITPase, encoded by the ITPA gene, and its orthologs (RdgB in Escherichia coli and HAM1 in Saccharomyces cerevisiae) exclude noncanonical nucleoside triphosphates (NTPs) from NTP pools...
  10. doi ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C
    Jacques Fellay
    Institute for Genome Sciences and Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina 27708, USA
    Nature 464:405-8. 2010
    ..Here we show that genetic variants leading to inosine triphosphatase deficiency, a condition not thought to be clinically important, protect against haemolytic anaemia in hepatitis-C-infected patients receiving RBV...
  11. doi Translating pharmacogenetics into clinical practice: interleukin (IL)28B and inosine triphosphatase (ITPA) polymophisms in hepatitis C virus (HCV) infection
    Elisabetta Cariani
    Clinical Pathology Toxicology, Ospedale Civile S Agostino Estense, Modena, Italy
    Clin Chem Lab Med 49:1247-56. 2011
    ..This review will cover recent reports on the subject, focusing on the potential use of the new genetic markers in the diagnostic algorithm for the stratification of patients for personalized antiviral regimens...
  12. ncbi Human inosine triphosphatase: catalytic properties and population studies
    S L Holmes
    Clin Chim Acta 97:143-53. 1979
    ..Using a reliable 2-step colorimetric assay, some catalytic properties of human erythrocyte ITPase (inosine triphosphate pyrophosphohydrolase) (EC 3.6.1.19) were determined...
  13. ncbi Individual variation in inosine triphosphate accumulation in human erythrocytes
    J H Fraser
    Clin Biochem 8:353-64. 1975
    ..The metabolism of [14C]adenine and [14C]guanine was the same in erythrocytes that accumulated "normal" and "high" amounts of inosine triphosphate. Inosine triphosphate did not accumulate in leukocytes...
  14. ncbi DNA polymorphisms in ITPA including basis of inosine triphosphatase deficiency
    Henian Cao
    Blackburn Cardiovascular Genetics Laboratory, Robarts Research Institute, 406 100 Perth Drive, London, ON N6A 5K8, Canada
    J Hum Genet 47:620-2. 2002
    ..6.1.19), which is encoded by ITPA on chromosome 20p...
  15. ncbi Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase)
    Anthony M Marinaki
    Purine Research Laboratory, Department of Chemical Pathology and Department of Gastroenterology, Guy s and St Thomas Hospital, London, UK
    Pharmacogenetics 14:181-7. 2004
    ..b>Inosine triphosphate pyrophosphatase (ITPase) deficiency results in the benign accumulation of the inosine nucleotide ITP...
  16. ncbi Association of inosine triphosphatase 94C>A and thiopurine S-methyltransferase deficiency with adverse events and study drop-outs under azathioprine therapy in a prospective Crohn disease study
    Nicolas von Ahsen
    Department of Clinical Chemistry, University of Gottingen, Gottingen, Germany
    Clin Chem 51:2282-8. 2005
    ..Inosine triphosphatase (ITPA) mutations are other pharmacogenetic polymorphisms possibly involved in thiopurine metabolism and tolerance.
  17. ncbi Analysis of ITPA phenotype-genotype correlation in the Bulgarian population revealed a novel gene variant in exon 6
    Srebrena Atanasova
    Department of Clinical Chemistry, Georg August University Goettingen, Goettingen, Germany
    Ther Drug Monit 29:6-10. 2007
    Mutations in the inosine triphosphate pyrophosphohydrolase (ITPA) gene causing enzyme deficiency were shown to have pharmacogenetic implications in azathioprine-induced adverse drug reactions...
  18. pmc Genetic polymorphism of inosine triphosphate pyrophosphatase is a determinant of mercaptopurine metabolism and toxicity during treatment for acute lymphoblastic leukemia
    G Stocco
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Clin Pharmacol Ther 85:164-72. 2009
    The influence of genetic polymorphism in inosine triphosphate pyrophosphatase (ITPA) on thiopurine-induced adverse events has not been investigated in the context of combination chemotherapy for acute lymphoblastic leukemia (ALL)...
  19. doi Influences of thiopurine methyltransferase genotype and activity on thiopurine-induced leukopenia in Korean patients with inflammatory bowel disease: a retrospective cohort study
    Jae Hak Kim
    Department of Internal Medicine, Dongguk University College of Medicine, Goyang si, Korea
    J Clin Gastroenterol 44:e242-8. 2010
    ..of this study was to investigate the relative risk of the thiopurine methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) genotypes and TPMT activity for the development of leukopenia in Korean IBD patients during ..
  20. pmc Variants in the ITPA gene protect against ribavirin-induced hemolytic anemia and decrease the need for ribavirin dose reduction
    Alexander J Thompson
    Duke Clinical Research Institute, Durham, North Carolina 27715, USA
    Gastroenterology 139:1181-9. 2010
    ..patients being treated for chronic hepatitis C, 2 functional variants in ITPA that cause inosine triphosphatase (ITPase) deficiency were shown to protect against ribavirin (RBV)-induced hemolytic anemia during early stages of ..
  21. doi ITPA polymorphism affects ribavirin-induced anemia and outcomes of therapy--a genome-wide study of Japanese HCV virus patients
    Hidenori Ochi
    Laboratory for Liver Diseases, RIKEN Center for Genomic Medicine, Hiroshima, Japan
    Gastroenterology 139:1190-7. 2010
    ..Factors influencing this anemia, especially host genetic factors, are poorly understood. In this study we investigated predictive factors in hepatitis C virus patients treated with combination therapy...
  22. doi Influence of ITPA polymorphisms on decreases of hemoglobin during treatment with pegylated interferon, ribavirin, and telaprevir
    Fumitaka Suzuki
    Department of Hepatology, Toranomon Hospital, Tokyo, Japan
    Hepatology 53:415-21. 2011
    Polymorphisms of the inosine triphosphatase (ITPA) gene influence anemia during pegylated interferon (PEG-IFN) and ribavirin (RBV) therapy, but their effects during triple therapy with PEG-IFN, RBV, and telaprevir are not known...
  23. doi Genome-wide association study identified ITPA/DDRGK1 variants reflecting thrombocytopenia in pegylated interferon and ribavirin therapy for chronic hepatitis C
    Yasuhito Tanaka
    Department of Virology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Hum Mol Genet 20:3507-16. 2011
    ..29 × 10(-17) (OR = 4.5). Fine mapping with 22 SNPs around DDRGK1 and ITPA genes showed that rs11697186 at the GWAS stage had a strong linkage disequilibrium with rs1127354, known as a ..
  24. pmc Genome-wide association study of interferon-related cytopenia in chronic hepatitis C patients
    Alexander J Thompson
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27701, USA
    J Hepatol 56:313-9. 2012
    ..We performed a genome wide association study on a well-characterized genotype 1 HCV cohort to identify genetic determinants of peginterferon-α (pegIFN)-related thrombocytopenia, neutropenia, and leukopenia...
  25. doi Relationship between polymorphisms of the inosine triphosphatase gene and anaemia or outcome after treatment with pegylated interferon and ribavirin
    Masayuki Kurosaki
    Division of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Tokyo, Japan
    Antivir Ther 16:685-94. 2011
    A genome-wide association study revealed an association between variants of the inosine triphosphatase (ITPA) gene and ribavirin (RBV)-induced anaemia...
  26. pmc Pivotal role of inosine triphosphate pyrophosphatase in maintaining genome stability and the prevention of apoptosis in human cells
    Miriam Rose Menezes
    Eppley Institute for Research in Cancer and Allied Diseases, Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 7:e32313. 2012
    ..The precise role of the human ITPase, encoded by the ITPA gene, is not clearly defined...
  27. ncbi The ITPA c.94C>A and g.IVS2+21A>C sequence variants contribute to missplicing of the ITPA gene
    Monica Arenas
    Purine Research Laboratory, Department of Chemical Pathology, Guy s Hospital, London, SE1 9RT, UK, and Department of Paediatrics, Neonatology and Congenital Disorders, Nagoya City University, Japan
    Biochim Biophys Acta 1772:96-102. 2007
    b>Inosine triphosphate pyrophosphatase (ITPase) catalyzes the conversion of inosine triphosphate (ITP) to the correspondent monophosphate. The ITPA c.94C>A and g...
  28. doi Genetic polymorphism of inosine-triphosphate-pyrophosphatase influences mercaptopurine metabolism and toxicity during treatment of acute lymphoblastic leukemia individualized for thiopurine-S-methyl-transferase status
    Gabriele Stocco
    St Jude Children s Research Hospital, Department of Pharmaceutical Sciences, 262 Danny Thomas Place MS 272, Memphis, TN 38105, USA
    Expert Opin Drug Saf 9:23-37. 2010
    ..encoding an enzyme involved in mercaptopurine metabolism (SNP rs1127354 in inosine-triphospate-pyrophosphatase, ITPA), showing that genetic polymorphism of ITPA is a significant determinant of mercaptopurine metabolism and of ..
  29. doi ITPase-deficient mice show growth retardation and die before weaning
    M Behmanesh
    Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
    Cell Death Differ 16:1315-22. 2009
    b>Inosine triphosphate pyrophosphatase (ITPase), the enzyme that hydrolyzes ITP and other deaminated purine nucleoside triphosphates to the corresponding purine nucleoside monophosphate and pyrophosphate, is encoded by the Itpa gene...
  30. doi ITPA protein, an enzyme that eliminates deaminated purine nucleoside triphosphates in cells
    Kunihiko Sakumi
    Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Mutat Res 703:43-50. 2010
    b>Inosine triphosphate pyrophosphatase (ITPA protein) (EC 3.6.1.19) hydrolyzes deaminated purine nucleoside triphosphates, such as ITP and dITP, to their corresponding purine nucleoside monophosphate and pyrophosphate...
  31. ncbi Relevance of pharmacogenetic aspects of mercaptopurine metabolism in the treatment of interstitial lung disease
    Jaap A Bakker
    Department of Clinical Genetics, The Netherlands
    Curr Opin Pulm Med 13:458-63. 2007
    ..Mercaptopurine therapy is increasingly important as immunosuppressive therapy in interstitial lung disease. We focus on human mercaptopurine metabolism and the defects in this metabolism causing adverse drug reactions...
  32. ncbi [Working memory, phonological awareness and spelling hypothesis]
    Gigiane Gindri
    Universidade Federal de Santa Maria, Brazil
    Pro Fono 19:313-22. 2007
    ..Working memory, phonological awareness and spelling hypothesis...
  33. ncbi Gender differences in outcome after neonatal intensive care: speech and language skills are less influenced in boys than in girls at 6.5 years
    M Jennische
    Department of Women s and Children s Health, Section for Pediatrics and Perinatal Research Laboratory, Uppsala University Children s Hospital, Uppsala, Sweden
    Acta Paediatr 92:364-78. 2003
    ..To study language development at age 6.5 y in 230 children who had required neonatal intensive care (NIC) and 71 full-term neonatally healthy control children, all born in 1986-1989, with a focus on comparison between genders...
  34. ncbi Pharmacogenetics of thiopurines in inflammatory bowel disease
    Luc J J Derijks
    Department of Clinical Pharmacy, Maxima Medical Centre, PO Box 7777, 5500 MB Veldhoven, The Netherlands
    Curr Pharm Des 16:145-54. 2010
    ..of genes encoding for glutathione S-tranferases, xanthine oxidase, thiopurine S-methyltransferase, inosine triphosphate pyrophosphatase, hypoxanthine phosphoribosyltransferase, inosine monophosphate dehydrogenase and multidrug ..
  35. ncbi A Japanese case with inosine triphosphate pyrophosphohydrolase deficiency attributable to an enzymatic defect in white blood cells
    S Sumi
    Department of Pediatrics, Nagoya City University, Graduate School of Medical Sciences, Mizuyo ku, Nagoya, Japan
    J Inherit Metab Dis 27:277-8. 2004
    b>Inosine triphosphate pyrophosphohydrolase (ITPase) deficiency is characterized by abnormal accumulation of inosine triphosphate...
  36. doi Clinical pharmacology and pharmacogenetics of thiopurines
    Srikumar Sahasranaman
    Drug Metabolism and Pharmacokinetics, Novartis Pharmaceuticals Corporation, One Health Plaza, East Hanover, NJ 07936, USA
    Eur J Clin Pharmacol 64:753-67. 2008
    ..of the mechanism of action as well as the molecular basis and interethnic variations of TPMT and inosine triphosphate pyrophosphatase (ITPase; EC 3.6.1.19), another enzyme implicated in thiopurine toxicity...
  37. ncbi Characterization of the structure and expression of mouse Itpa gene and its related sequences in the mouse genome
    Mehrdad Behmanesh
    Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
    DNA Res 12:39-51. 2005
    In the mouse genome, we found one processed Itpa gene-like sequence and two processed Itpa pseudogenes as well as the Itpa gene itself with introns, located on chromosome 2F3, which was isolated by a retro-recombination method...
  38. ncbi Glutamine 170 to tyrosine substitution in yeast mitochondrial F1 beta-subunit increases catalytic site interaction with GDP and IDP and produces negative cooperativity of GTP and ITP hydrolysis
    J M Jault
    Department of Chemistry, University of California at San Diego, La Jolla 92093 0601
    J Biol Chem 268:20762-7. 1993
    ..for GDP, IDP, and guanosine 5'-(beta,gamma-imidotriphosphate), which are competitive inhibitors of GTPase and ITPase activities...
  39. ncbi Linguistic skills in relation to neurological findings at 8 years of age in children born preterm
    A Yliherva
    Department of Finnish, Saami and Logopedics, University of Oulu
    Logoped Phoniatr Vocol 26:66-75. 2001
    ..Finland were studied with three different language tests, namely the Illinois Test of Psycholinguistic Abilities (ITPA), the Token Test for Children (TTC) and the Morphological Test (MT) for Finnish children...
  40. doi The increasing complexity of mercaptopurine pharmacogenomics
    S Marsh
    Genome Quebec and Montreal Heart Institute Pharmacogenomics Centre, Montreal, Quebec, Canada
    Clin Pharmacol Ther 85:139-41. 2009
    ..However, recent research has shown that genetic contribution to mercaptopurine toxicity is more complex, possibly involving other genes, in particular ITPA, which encodes inosine triphosphate pyrophosphatase.
  41. pmc Effects of a computer-supported interactive tailored patient assessment tool on patient care, symptom distress, and patients' need for symptom management support: a randomized clinical trial
    Cornelia M Ruland
    Center for Shared Decision Making and Nursing Research, Rikshospitalet, Oslo University Hospital, Oslo, Norway
    J Am Med Inform Assoc 17:403-10. 2010
    To examine the effects of a computer-assisted, interactive tailored patient assessment (ITPA) tool in oncology practice on: documented patient care, symptom distress, and patients' need for symptom management support during treatment and ..
  42. ncbi HIV and syphilis: when to perform a lumbar puncture
    Agnes Libois
    Service des Maladies Infectieuses, CHU Saint Pierre, 322 rue Haute, 1000 Brussels, Belgium
    Sex Transm Dis 34:141-4. 2007
    ..The objectives of this study were to determine predictive factors for neurosyphilis in HIV-infected patients with syphilis and optimize the use of lumbar puncture...
  43. doi Role of IL28B and inosine triphosphatase polymorphisms in the treatment of chronic hepatitis C virus genotype 6 infection
    W K Seto
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong
    J Viral Hepat 20:470-7. 2013
    IL28B and inosine triphosphatase (ITPA) polymorphisms are able to predict treatment response and degree of ribavirin-related anaemia, respectively, in the treatment of chronic hepatitis C virus (HCV) infection...
  44. pmc Predictors of consent to pharmacogenomics testing in the IDEAL study
    Alison B Jazwinski
    aDepartment of Medicine, Division of Gastroenterology and Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina bDepartment of Medicine, Division of Gastroenterology Hepatology, Henry Ford Hospital, Detroit, Michigan cDepartment of Medicine, Alamo Medical Research, San Antonio, Texas dMerck Research Laboratories, Department of Infectious Disease, Whitehouse Station, New Jersey eDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA fDepartment of Gastroenterology, St Vincent s Hospital, University of Melbourne, Melbourne, Victoria, Australia
    Pharmacogenet Genomics 23:619-23. 2013
    ..Genome-wide association studies subsequently identified associations between IL28B polymorphism and sustained virologic response, and ITPA polymorphism and ribavirin-associated anemia.
  45. pmc Prevalence of TPMT and ITPA gene polymorphisms and effect on mercaptopurine dosage in Chilean children with acute lymphoblastic leukemia
    Mauricio J Farfan
    Departamento de Pediatria, Centro de Estudios Moleculares, Facultad de Medicina, Universidad de Chile, Antonio Varas 360, Santiago, Chile
    BMC Cancer 14:299. 2014
    ..We determined the prevalence of the major genetic polymorphisms in 6-MP metabolizing enzymes in Chilean children with ALL...
  46. doi Pharmacogenetics and induction/consolidation therapy toxicities in acute lymphoblastic leukemia patients treated with AIEOP-BFM ALL 2000 protocol
    R Franca
    Institute for Maternal and Child Health IRCCS Burlo Garofolo, UO Pediatric Hemato Oncology, Trieste, Italy
    Pharmacogenomics J . 2015
    ..2%) and NEU in 44 (8.7%). Logistic regression model adjusted for sex, risk and treatment phase revealed that ITPA rs1127354 homozygous mutated patients showed an increased risk of severe GI and NEU...
  47. doi Does Epoetin Beta Still Have a Place in Peginterferon Alpha-2a Plus Ribavirin Treatment Strategies for Chronic Hepatitis C?
    Pascal Veillon
    1 Department of Virology, University Hospital of Angers, Angers, France
    J Interferon Cytokine Res 36:204-14. 2016
    ..lambda 3 (IFNL3) (rs12979860 and rs8099917), interferon lambda 4 (IFNL4) (ss469415590), and inosine triphosphatase (ITPA) (rs1127354 and rs7270101) were determined retrospectively...
  48. doi Pharmacogenetics of ribavirin-induced anemia in hepatitis C
    Javier Ampuero
    Inter Centre Unit of Digestive Diseases, Virgen del Rocio Virgen Macarena University Hospitals, University of Sevilla, Sevilla, Spain
    Pharmacogenomics 17:1587-94. 2016
    ..Pharmacogenetics has identified ITPA and SLC28/29 genes to be closely related to RBV-induced anemia...
  49. ncbi Determination of ITPase activity in erythrocyte lysates obtained for determination of TPMT activity
    J Bierau
    Laboratory of Biochemical Genetics, Department of Clinical Genetics, Maastricht University Hospital, Maastricht, The Netherlands
    Nucleosides Nucleotides Nucleic Acids 25:1129-32. 2006
    The indication for the determination of both thiopurine methyltransferase (TPMT) and inosine triphosphate pyrophosphohydrolase is identical (i.e., adverse drug reactions toward mercaptopurines)...
  50. doi Isothermal target and signaling probe amplification method, based on a combination of an isothermal chain amplification technique and a fluorescence resonance energy transfer cycling probe technology
    Cheulhee Jung
    Department of Chemical and Biomolecular Engineering, KAIST, 335 Gwahak ro, Yuseong Gu, Daejeon, Republic of Korea
    Anal Chem 82:5937-43. 2010
    An iTPA (isothermal target and signaling probe amplification) method for the quantitative detection of nucleic acids, based on a combination of novel ICA (isothermal chain amplification) and fluorescence resonance energy transfer cycling ..
  51. doi The activity of the inosine triphosphate pyrophosphatase affects toxicity of 6-mercaptopurine during maintenance therapy for acute lymphoblastic leukemia in Japanese children
    Yoichi Tanaka
    Department of Clinical Pharmacy, Center for Clinical Pharmacy and Sciences, School of Pharmacy, Kitasato University, Tokyo, Japan
    Leuk Res 36:560-4. 2012
    The association between inosine triphosphate pyrophosphatase (ITPA) activity and toxicity of 6-mercaptopurine (6-MP) was retrospectively evaluated in 65 Japanese children with acute lymphoblastic leukemia (ALL)...
  52. doi Genetic polymorphisms in key methotrexate pathway genes are associated with response to treatment in rheumatoid arthritis patients
    S A Owen
    Arthritis Research UK Epidemiology Unit, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, UK
    Pharmacogenomics J 13:227-34. 2013
    ..polymorphisms (SNPs) spanning 10 methotrexate (MTX) pathway genes, namely AMPD1, ATIC, DHFR, FPGS, GGH, ITPA, MTHFD1, SHMT1, SLC19A1 (RFC) and TYMS on the outcome of MTX treatment in a UK rheumatoid arthritis (RA) patient ..
  53. pmc ITPA gene polymorphisms significantly affect hemoglobin decline and treatment outcomes in patients coinfected with HIV and HCV
    Anu Osinusi
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Disease, NIH, Bethesda, MD, USA
    J Med Virol 84:1106-14. 2012
    ..studies have described a strong association with a single-nucleotide polymorphism (SNP) in the inosine triphosphate pyrophosphatase (ITPA) gene and ribavirin (RBV)-induced hemolytic anemia in HCV-infected patients receiving ..
  54. doi Genetic variants of thiopurine and folate metabolic pathways determine 6-MP-mediated hematological toxicity in childhood ALL
    Patchva Dorababu
    Department of Medical Oncology, Nizam s Institute of Medical Sciences, Panjagutta, Hyderabad, Andhra Pradesh, PIN 500082, India
    Pharmacogenomics 13:1001-8. 2012
    ..6-MP)-mediated hematological toxicity in children with acute lymphoblastic leukemia (ALL) and to explore the interaction of these variants with TPMT and ITPA haplotypes using multifactor dimensionality reduction analysis.
  55. pmc A Ham1p-dependent mechanism and modulation of the pyrimidine biosynthetic pathway can both confer resistance to 5-fluorouracil in yeast
    Mattias Carlsson
    Department of Microbiology, Swedish University of Agricultural Sciences, Uppsala, Sweden
    PLoS ONE 8:e52094. 2013
    ..Ham1p encodes an inosine triphosphate pyrophosphatase that has been implicated in resistance to purine analogues...
  56. doi Valuable antiviral therapeutic options for the treatment of chronic hepatitis C patients with thrombocytopenia
    E Ogawa
    Department of General Internal Medicine, Kyushu University Hospital, Fukuoka, Japan Department of Environmental Medicine and Infectious Disease, Kyushu University, Fukuoka, Japan
    J Viral Hepat 20:838-46. 2013
    ..The kinetics of haemoglobin and platelets according to the inosine triphosphatase (ITPA) genotype (rs1127354) were investigated...
  57. doi Significant early higher ribavirin plasma concentrations in patients receiving a triple therapy with pegylated interferon, ribavirin and telaprevir
    L Boglione
    Unit of Infectious Diseases, University of Turin, Department of Medical Sciences, Amedeo di Savoia Hospital, Turin, Italy
    J Viral Hepat 21:260-3. 2014
    ..Because haemolysis is a typical concentration-dependent side effect of RBV, modulated by ITPA gene polymorphisms, we aimed to compare the early RBV plasma exposure of nine patients after 2 weeks of treatment ..
  58. doi 5-Aminoimidazole-4-carboxamide ribonucleotide-transformylase and inosine-triphosphate-pyrophosphatase genes variants predict remission rate during methotrexate therapy in patients with juvenile idiopathic arthritis
    Serena Pastore
    University of Trieste, Trieste, Italy
    Rheumatol Int 35:619-27. 2015
    ..those in 5-aminoimidazole-4-carboxamide ribonucleotide-transformylase (ATIC), inosine-triphosphate-pyrophosphatase (ITPA) and solute-liquid-carrier-19A1 genes...
  59. pmc Association between IPTA gene polymorphisms and hematological abnormalities in hepatitis C virus-infected patients receiving combination therapy
    Jow Jyh Hwang
    Section of Gastroenterology and Hepatology, Department of Internal Medicine, St Martin De Porres Hospital and Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Chiayi, Taiwan
    Gut Liver 9:214-23. 2015
    ..Variants of the ITPA gene have been reported to protect against anemia during the early stages of HCV combina-tion treatments but have ..
  60. doi Gene-gene interactions in folate and adenosine biosynthesis pathways affect methotrexate efficacy and tolerability in rheumatoid arthritis
    Thierry Dervieux
    Cypress Bioscience, San Diego, California 92121, USA
    Pharmacogenet Genomics 19:935-44. 2009
    ....
  61. doi Impact of inosine triphosphatase gene variants on the risk of anemia in HIV/hepatitis C virus-coinfected patients treated for chronic hepatitis C
    Norma I Rallon
    Infectious Diseases Department, Hospital Carlos III, Madrid, Spain
    Clin Infect Dis 53:1291-5. 2011
    The role of rs1127354/rs7270101 alleles at the inosine triphosphatase (ITPA) gene on ribavirin-induced anemia was assessed in 74 patients with hepatitis C virus and human immunodeficiency virus coinfection...
  62. ncbi Efficacy of splenectomy in preventing anemia in patients with recurrent hepatitis C following liver transplantation is not dependent on inosine triphosphate pyrophosphatase genotype
    Takashi Motomura
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Hepatol Res 42:288-95. 2012
    Aim:  A genetic polymorphism of inosine triphosphate pyrophosphatase (ITPA) has been associated with pegylated-interferon/ribavirin (PEG-IFN/RBV)-induced anemia in chronic hepatitis C patients...
  63. pmc Erythrocyte inosine triphosphatase activity is decreased in HIV-seropositive individuals
    Jörgen Bierau
    Department of Clinical Genetics, Maastricht University Medical Centre, Maastricht, The Netherlands
    PLoS ONE 7:e30175. 2012
    Inosine triphosphatase (ITPase) is encoded by the polymorphic gene ITPA and maintains low intracellular levels of the inosine nucleotides ITP and dITP. The most frequently reported polymorphisms are ITPA c.94C>A (rs 1127354) and ITPA c...
  64. doi Azathioprine in the treatment of autoimmune blistering diseases
    Volker Meyer
    Department of Dermatology, University of Muenster, Von Esmarch Str 58, D 48149 Muenster, Germany
    Immunol Allergy Clin North Am 32:295-307, vii-viii. 2012
    ..Severe reactions are due to reduced thiopurine S-methyltransferase (TPMT) or inosine triphosphate pyrophosphohydrolase (ITPA) activity...
  65. doi Determination of inosine triphosphate pyrophosphatase phenotype in human red blood cells using HPLC
    Antony Citterio-Quentin
    Institut des Sciences Parmaceutiques et Biologiques, Pharmacie Clinique, Pharmacocinétique et Évaluation du Médicament, Universite de Lyon, Universite Lyon 1, Lyon, France
    Ther Drug Monit 34:477-80. 2012
    ..Recent articles have reported that inosine triphosphate pyrophosphatase (ITPase) deficiency was associated with adverse drug reactions toward thiopurine drug therapy...
  66. pmc Roles of ITPA and IL28B genotypes in chronic hepatitis C patients treated with peginterferon plus ribavirin
    Tatsuo Miyamura
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan
    Viruses 4:1264-78. 2012
    It has been reported that inosine triphosphatase (ITPA) gene variants protect against ribavirin-induced anemia in patients treated for chronic hepatitis C...
  67. pmc Effect of laparoscopic splenectomy in patients with Hepatitis C and cirrhosis carrying IL28B minor genotype
    Takashi Motomura
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    BMC Gastroenterol 12:158. 2012
    IL28B and ITPA genetic variants are associated with the outcome of pegylated-interferon and ribavirin (PEG-IFN/RBV) therapy...
  68. pmc Multilocus genotypes of relevance for drug metabolizing enzymes and therapy with thiopurines in patients with acute lymphoblastic leukemia
    Gabriele Stocco
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital Memphis, TN, USA Department of Life Sciences, University of Trieste Trieste, Italy
    Front Genet 3:309. 2012
    ..We have recently demonstrated that TPMT and ITPA genotypes constitute a multilocus genotype of pharmacogenetic relevance for children with acute lymphoblastic ..
  69. pmc Inosine triphosphate pyrophosphohydrolase (ITPA) polymorphic sequence variants in Chinese ALL children and possible association with mercaptopurine related toxicity
    Xiaoli Ma
    Hematology Oncology Center, Beijing Children s Hospital, Capital Medical University Beijing 100045, China
    Int J Clin Exp Pathol 7:4552-6. 2014
    ..investigate whether there was a correlation between genotype or haplotype of inosine triphosph pyrophosphohydrolase(ITPA) and toxicities during maintenance therapy with mercaptopurine (6-MP) in Chinese patients with acute lymphoblastic ..
  70. doi Mycophenolate mofetil may induce prolonged severe anemia during pegylated-interferon/ribavirin/simeprevir therapy in liver transplant recipients
    Tomomi Kogiso
    Department of Internal Medicine, Institute of Gastroenterology, Tokyo Women s Medical University, 8 1, Kawada cho, Shinjuku ku, Tokyo, 162 8666, Japan
    Clin J Gastroenterol 8:156-61. 2015
    ..These patients had the C/C major type inosine triphosphatase (ITPA) polymorphism...
  71. doi Role of ITPA and SLC28A2 genes in the prediction of anaemia associated with protease inhibitor plus ribavirin and peginterferon in hepatitis C treatment
    Javier Ampuero
    Unit for the Clinical Management of Digestive Diseases, Valme University Hospital and CIBERehd, Sevilla, Spain
    J Clin Virol 68:56-60. 2015
    ..Anaemia is a common side-effect of ribavirin (RBV) use that overwhelms management of hepatitis C when protease inhibitors are added...
  72. doi Frequency of ITPA gene polymorphisms in Iranian patients with acute lymphoblastic leukemia and prediction of its myelosuppressive effects
    Fatemeh Azimi
    Molecular Medicine and Genetics Departments, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
    Leuk Res 39:1048-54. 2015
    ..b>Inosine triphosphate pyrophosphohydrolase (ITPA) is an enzyme involved in 6-MP metabolic pathway that convert the inosine triphosphate (..
  73. pmc Modeling Ribavirin-Induced Anemia in Patients with Chronic Hepatitis C Virus
    L S Wu
    University of Southern California, Biomedical Engineering Los Angeles California USA
    CPT Pharmacometrics Syst Pharmacol 5:65-73. 2016
    ..Inosine triphosphatase (ITPA) and interleukin 28B (IL28B) genetics were found to be significant covariates...
  74. doi Correlations between behavior, memory, sleep-wake and melatonin in Williams-Beuren syndrome
    Stella Donadon Santoro
    Sao Paulo State University UNESP, Marilia, SP, Brazil
    Physiol Behav 159:14-9. 2016
    ..scale for auditory memory, the visual sequential memory subtest of the Illinois Test of Psycholinguistic Abilities (ITPA) and the Sleep Disturbance Scale for Children (SDSC)...
  75. doi Severe 6-mercaptopurine-induced hematotoxicity in childhood an ALL patient with homozygous NUDT15 missence variants
    Shunsuke Kimura
    Department of Pediatrics, St Luke s International Hospital
    Rinsho Ketsueki 57:748-53. 2016
    ..for 6MP-associated myelotoxicity and found homozygous NUDT15 variant alleles and a heterozygous inosine triphosphate pyrophosphatase (ITPA) variant allele...
  76. pmc A disease spectrum for ITPA variation: advances in biochemical and clinical research
    Nicholas E Burgis
    Department of Chemistry and Biochemistry, Eastern Washington University, 226 Science Building, Cheney, WA, 99004, USA
    J Biomed Sci 23:73. 2016
    Human ITPase (encoded by the ITPA gene) is a protective enzyme which acts to exclude noncanonical (deoxy)nucleoside triphosphates ((d)NTPs) such as (deoxy)inosine 5'-triphosphate ((d)ITP), from (d)NTP pools...
  77. ncbi Inosine Triphosphate Pyrophosphohydrolase Expression: Decreased in Leukocytes of HIV-Infected Patients Using Combination Antiretroviral Therapy
    N Chantal Peltenburg
    Department of Internal Medicine, Division of Infectious Diseases, Erasmus MC, Rotterdam, the Netherlands Department of Clinical Chemistry and Hematology, Zuyderland Medical Center, Heerlen, the Netherlands Department of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden, the Netherlands Departments of Medical Microbiology Internal Medicine, Division of Infectious Diseases, Research School Caphri, Maastricht University Medical Center, Maastricht, The Netherlands Department of Clinical Genetics, Maastricht University Medical Centre, Maastricht, the Netherlands and Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands
    J Acquir Immune Defic Syndr 73:390-395. 2016
    In HIV-infected patients, the enzyme Inosine triphosphate pyrophosphohydrolase (ITPase), involved in purine nucleotide homeostasis, was found to be decreased in erythrocytes...
  78. doi ITPA polymorphism correlates with the reductions in hemoglobin concentration and ribavirin dose during sofosbuvir and ribavirin therapy
    Ritsuzo Kozuka
    Department of Hepatology, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Gastroenterol Hepatol . 2017
    It is unclear whether polymorphism in the inosine triphosphatase (ITPA) gene correlates with the reduction in hemoglobin (Hb) concentrations during sofosbuvir (SOF) and ribavirin (RBV) therapy...
  79. doi Determination of inosine 5'-monophosphate dehydrogenase activity in red blood cells of thiopurine-treated patients using HPLC
    Audrey Beringer
    Universite de Lyon, Universite Lyon 1, UMR CNRS 5305, Pharmacie Clinique, Pharmacocinétique et Évaluation du Médicament, Lyon, France Hospices civils de Lyon, Groupement Hospitalier Edouard Herriot, Laboratoire de Biologie Médicale Multi Sites du CHU de Lyon, unité de Pharmacocinétique Clinique, Lyon, France
    J Chromatogr B Analyt Technol Biomed Life Sci . 2017
    ..The potential implication of other enzymes involved in thiopurine metabolism, such as ITPA, has been investigated over the last decade but little data is available on inosine 5'-monophosphate dehydrogenase (..
  80. ncbi Localization of the inosine triphosphatase locus (Itp) on chromosome 2 of the mouse
    B A Taylor
    Biochem Genet 25:267-74. 1987
    ..The mapping of Itp on chromosome 2 identifies a chromosomal segment that has been conserved since the divergence of lineages leading to mouse and man...
  81. ncbi [Higher brain dysfunction in benign childhood epilepsy with centrotemporal spike and atypical benign partial epilepsy of childhood]
    Junri Hattori
    Department of Child Neurology, Okayama University Graduate School of Medicine and Dentistry, Okayama
    No To Hattatsu 34:484-90. 2002
    ..K-ABC), Wechsler intelligence scales for children-revised (WISC-R), Illinois test of psycholinguistic abilities (ITPA), Benton visual retention test (BVRT), Token test, calculation, figure copying task, letter copying task, line ..
  82. doi Analysis of human ITPase nucleobase specificity by site-directed mutagenesis
    Amanda D Gall
    Department of Chemistry and Biochemistry, Eastern Washington University, 226 Science Building, Cheney, WA 99004, USA
    Biochimie 95:1711-21. 2013
    Inosine triphosphate (ITP) pyrophosphohydrolase, or ITPase, is an intracellular enzyme that is responsible for the hydrolysis of the acidic anhydride bond between the alpha and beta phosphates in ITP, and other noncanonical nucleoside ..
  83. pmc The impact of inosine triphosphatase variants on hemoglobin level and sustained virologic response of chronic hepatitis C in Korean
    Ju Seung Kim
    Division of Gastroenterology, Department of Internal Medicine, Gachon University, Gil Medical Center, Incheon, Korea
    J Korean Med Sci 28:1213-9. 2013
    rs1127354, rs7270101) gene cause ITPA deficiency and protect against the hemolytic toxicity of ribavirin...
  84. doi Inosine triphosphatase deficiency helps predict anaemia, anaemia management and response in chronic hepatitis C therapy
    P J Clark
    GI Hepatology, Duke Clinical Research Institute, Durham, NC, USA Princess Alexandra Hospital, Brisbane, QLD, Australia Queensland Institute of Medical Research, Brisbane, QLD, Australia
    J Viral Hepat 20:858-66. 2013
    ..Inosine triphosphatase (ITPA) genetic variants are associated with ribavirin-induced anaemia and dose reduction; however, their impact in real-..
  85. doi The role of viral and host genetics in natural history and treatment of chronic HCV infection
    Joseph S Doyle
    Centre for Population Health, Burnet Institute, 85 Commercial Road, Melbourne, VIC 3004, Australia
    Best Pract Res Clin Gastroenterol 26:413-27. 2012
    ..treatment outcome: IL28B polymorphism is associated with spontaneous clearance and treatment responsiveness; ITPA polymorphism protects against ribavirin-induced anaemia and dose reductions; genetic determinants of liver fibrosis ..
  86. doi Allelic inhibition of displacement activity: a simplified one tube allele-specific PCR for evaluation of ITPA polymorphisms
    E Galmozzi
    First Division of Gastroenterology, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Universita degli Studi di Milano, Milan, Italy
    J Virol Methods 187:271-3. 2013
    ..infection have identified two functional single nucleotide polymorphisms (SNPs) in the inosine triphosphatase (ITPA) gene, that are associated strongly and independently with hemolytic anemia in patients exposed to pegylated-..
  87. doi A novel multiparameter flow cytometric assay for inosine triphosphatase expression analysis in leukocytes
    Wim H M Vroemen
    Department of Clinical Chemistry and Hematology, Atrium Medical Center Parkstad, Heerlen, The Netherlands
    Cytometry A 81:672-8. 2012
    The aim of this study was to assess inosine triphosphate (ITPase) expression in the different leukocyte populations present in peripheral blood samples of a nonimmune compromised control group...
  88. doi Genetic variants at the ITPA locus protect against ribavirin-induced hemolytic anemia and dose reduction in an HCV G2/G3 cohort
    Arne Nørgaard Eskesen
    Department of Infectious Diseases, Medical Division, Akershus University Hospital, Lørenskog, Norway
    Eur J Gastroenterol Hepatol 24:890-6. 2012
    Two functional genetic variants in the inosine triphosphatase (ITPA) gene have been shown to be strongly associated with protection from ribavirin (RBV)-induced hemolysis...
  89. doi Genomic variation-guided management in chronic hepatitis C
    Ching Sheng Hsu
    Division of Gastroenterology, Department of Internal Medicine, Buddhist Tzu Chi General Hospital, Taipei Branch, Taiwan
    Expert Rev Gastroenterol Hepatol 6:497-506. 2012
    ..Following these studies, ITPA gene variants were reported to affect ribavirin-induced anemia and therapeutic outcomes of CHC patients...
  90. ncbi The Fagan Test of Infant Intelligence: predictive validity in a random sample
    H W Andersson
    Department of Psychology, University of Trondheim, Dragvoll, Norway
    Psychol Rep 78:1015-26. 1996
    ..Scale of Intelligence-Revised (WPPSI-R) and three subtests from the Illinois Test of Psycholinguistic Abilities (ITPA). Low internal consistency of the Fagan test was found, with alphas of .10 and .02 for the two study sites...
  91. ncbi [Basic patterns of learning disability: follow-up study of very low birth weight children]
    M Ishikawa
    Nagoya City District Care Center for Disabled Children
    No To Hattatsu 31:229-36. 1999
    ..mental development of VLBW without major handicap was investigated using several neuropsychological tests (ITPA, BGT, WISC-R) suitable for their ages...
  92. ncbi Identification of an ITPase/XTPase in Escherichia coli by structural and biochemical analysis
    Jimin Zheng
    Department of Biochemistry, Queen s University, Kingston, Ontario K7L 3N6, Canada
    Structure 13:1511-20. 2005
    ..The enzymatic activity of YjjX as an inosine/xanthosine triphosphatase provides evidence for a plausible protection mechanism by clearing the noncanonical nucleotides from the cell during oxidative stress in E. coli...
  93. pmc Pharmacogenetics during standardised initiation of thiopurine treatment in inflammatory bowel disease
    U Hindorf
    Department of Clinical Sciences, Division of Gastroenterology, Faculty of Medicine, Lund University, 22185 Lund, Sweden
    Gut 55:1423-31. 2006
    ..Firm recommendations about the way thiopurine drugs are introduced and the use of thiopurine methyltransferase (TPMT) and metabolite measurements during treatment in inflammatory bowel disease (IBD) are lacking...
  94. ncbi Linguistic features of Japanese twins at 3 or 4 years of age evaluated by Illinois test of psycholinguistic abilities
    Yoko Kobayashi
    Department of Health Promotion Science, Faculty of Health Science Graduate School of Medicine, Osaka University, Osaka, Japan
    Twin Res Hum Genet 9:272-8. 2006
    ..A Japanese version of the Illinois Test of Psycholinguistic Abilities (ITPA) was administered in 24 twin pairs (aged 3 to 4 years) at their own homes...
  95. ncbi No induction of thiopurine methyltransferase during thiopurine treatment in inflammatory bowel disease
    M Lindqvist
    Department of Medicine and Care, Division of Clinical Pharmacology, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Nucleosides Nucleotides Nucleic Acids 25:1033-7. 2006
    ..gene expression and enzyme activity and thiopurine metabolite concentrations, and to study the role of TPMT and ITPA 94C > A polymorphisms for the development of adverse drug reactions...
  96. pmc Reliability and validity issues related to interactive tailored patient assessments: a case study
    Cornelia M Ruland
    Center for Shared Decision Making and Nursing Research, Rikshospitalet Medical Center, Oslo, Norway
    J Med Internet Res 9:e22. 2007
    Recently there has been a proliferation of interactive tailored patient assessment (ITPA) tools...
  97. ncbi Molecular basis of the antimutagenic activity of the house-cleaning inosine triphosphate pyrophosphatase RdgB from Escherichia coli
    Alexei Savchenko
    Banting and Best Department of Medical Research and Ontario Center for Structural Proteomics, University of Toronto, 112 College Street, Toronto, Ontario, Canada M5G 1L6
    J Mol Biol 374:1091-103. 2007
    ..Here we present the 1.5-A-resolution crystal structure of the inosine triphosphate pyrophosphatase RdgB from Escherichia coli in a free state and in complex with a substrate (ITP+Ca(2+)) or a ..
  98. doi Inosine triphosphate pyrophosphatase 94C>A polymorphism: clinical implications for patients with systemic lupus erythematosus treated with azathioprine
    Koujirou Yamamoto
    Gunma University Graduate School of Medicine, Department of Clinical Pharmacology, Maebashi, Japan
    Expert Opin Drug Saf 9:447-57. 2010
    ..Under AZA therapy, inosine triphosphate pyrophosphatase (ITPA) deficiency presumably leads to accumulation of unusual thioinosine metabolites with the ..
  99. doi Common genetic polymorphism of ITPA gene affects ribavirin-induced anemia and effect of peg-interferon plus ribavirin therapy
    Takahiro Azakami
    Laboratory for Digestive Diseases, Center for Genomic Medicine, RIKEN, Hiroshima, Japan
    J Med Virol 83:1048-57. 2011
    An association between a single nucleotide polymorphism (SNP) in the inosine triphosphate pyrophosphatase (ITPA) gene and reduction of hemoglobin during peg-interferon plus ribavirin combination therapy for patients with chronic hepatitis ..
  100. doi The impact of human gene polymorphisms on HCV infection and disease outcome
    Esperance A K Schaefer
    GI Unit, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Semin Liver Dis 31:375-86. 2011
    ..b>ITPA is a gene on chromosome 20, coding for inosine triphosphatase, and polymorphisms on this gene have been associated ..

Research Grants2

  1. Ribavirin depletes endogenous nucleotide pools
    JENNIFER JUSTICE KISER; Fiscal Year: 2013
    ..the red blood and peripheral blood mononuclear cells of HCV-infected patients on ribavirin-based treatment across ITPA activity phenotype groups and (2) to determine associations between endogenous purine depletion and virologic ..
  2. A Parallel High-Throughput Pharmacogenetic Profiling Assay for Clinical Use
    Gao Chen; Fiscal Year: 2009
    ..detector to decode and detect fluorescence one by one;(3) developed multiplex PCR for P450 (CYP2A7), KCNA5 and ITPase, and bead hybridization;and (4) evaluated the SNP genotyping assay using multiplex PCR amplified sequences...