ITM2B

Summary

Gene Symbol: ITM2B
Description: integral membrane protein 2B
Alias: ABRI, BRI, BRI2, BRICD2B, E25B, E3-16, FBD, RDGCA, imBRI2, integral membrane protein 2B, ABri/ADan amyloid peptide, BRICHOS domain containing 2B, immature BRI2, transmembrane protein BRI
Species: human

Top Publications

  1. ncbi A stop-codon mutation in the BRI gene associated with familial British dementia
    R Vidal
    Department of Pathology, New York University School of Medicine, New York 10016, USA
    Nature 399:776-81. 1999
  2. ncbi Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia
    S H Kim
    Department of Neurobiology, Pharmacology and Physiology, The University of Chicago, Abbott 316, 947 East 58th Street, Chicago, Illinois 60637, USA
    Nat Neurosci 2:984-8. 1999
  3. pmc A decamer duplication in the 3' region of the BRI gene originates an amyloid peptide that is associated with dementia in a Danish kindred
    R Vidal
    Department of Pathology, New York University School of Medicine, New York 10016, USA
    Proc Natl Acad Sci U S A 97:4920-5. 2000
  4. ncbi Axonal transport of British and Danish amyloid peptides via secretory vesicles
    Seung Il Choi
    Department of Pathology, New York University School of Medicine, New York, New York, USA
    FASEB J 18:373-5. 2004
  5. ncbi The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production
    Shuji Matsuda
    Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Biol Chem 280:28912-6. 2005
  6. ncbi BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production
    Angeliki Fotinopoulou
    Division of Animal and Human Physiology, Department of Biology, National and Kapodistrian University of Athens, 157 84 Panepistimiopolis, Ilisia, Athens, Greece
    J Biol Chem 280:30768-72. 2005
  7. ncbi Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b
    Lucas Martin
    Center for Integrated Protein Science Munich and Adolf Butenandt Institute, Department of Biochemistry, Laboratory for Neurodegenerative Disease Research, Ludwig Maximilians University, 80336 Munich, Germany
    J Biol Chem 283:1644-52. 2008
  8. doi Substrate requirements for SPPL2b-dependent regulated intramembrane proteolysis
    Lucas Martin
    Center for Integrated Protein Science Munich and Adolf Butenandt Institute, Department of Biochemistry, Laboratory for Neurodegenerative Disease Research, Ludwig Maximilians University, 80336 Munich, Germany
    J Biol Chem 284:5662-70. 2009
  9. pmc BRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2
    Shuji Matsuda
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 1046, USA
    J Biol Chem 284:15815-25. 2009
  10. pmc Memory deficits due to familial British dementia BRI2 mutation are caused by loss of BRI2 function rather than amyloidosis
    Robert Tamayev
    Department of Microbiology and Immunology, Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 30:14915-24. 2010

Research Grants

  1. JORGE A GHISO; Fiscal Year: 2014
  2. Dementia due to mutations in BRI2;link to Alzheimer's Disease
    Robert Tamayev; Fiscal Year: 2011
  3. Insulin/Insulin receptor modulate APP phosphorylation and dementia
    LUCIANO D'ADAMIO; Fiscal Year: 2013
  4. Cerebral Amyloidosis and Dementia
    JORGE A GHISO; Fiscal Year: 2013
  5. Rachel M Ceballos; Fiscal Year: 2015
  6. LUCIANO D'ADAMIO; Fiscal Year: 2015
  7. Jeffrey A Jones; Fiscal Year: 2016
  8. Thomas M Wisniewski; Fiscal Year: 2016
  9. Effect of sereted AB40 on the cognitive function in neurodegenerative disease
    Naruhiko Sahara; Fiscal Year: 2010
  10. Shivendra Singh; Fiscal Year: 2016

Detail Information

Publications193 found, 100 shown here

  1. ncbi A stop-codon mutation in the BRI gene associated with familial British dementia
    R Vidal
    Department of Pathology, New York University School of Medicine, New York 10016, USA
    Nature 399:776-81. 1999
    ..Here we report the identification of a unique 4K protein subunit named ABri from isolated amyloid fibrils...
  2. ncbi Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia
    S H Kim
    Department of Neurobiology, Pharmacology and Physiology, The University of Chicago, Abbott 316, 947 East 58th Street, Chicago, Illinois 60637, USA
    Nat Neurosci 2:984-8. 1999
    ..The mutant gene encodes BRI-L, the precursor of ABri peptides that accumulate in amyloid deposits in FBD brain...
  3. pmc A decamer duplication in the 3' region of the BRI gene originates an amyloid peptide that is associated with dementia in a Danish kindred
    R Vidal
    Department of Pathology, New York University School of Medicine, New York 10016, USA
    Proc Natl Acad Sci U S A 97:4920-5. 2000
    ..N-terminal sequence analysis of isolated leptomeningeal amyloid fibrils revealed homology to ABri, the peptide originated by a point mutation at the stop codon of gene BRI in familial British dementia...
  4. ncbi Axonal transport of British and Danish amyloid peptides via secretory vesicles
    Seung Il Choi
    Department of Pathology, New York University School of Medicine, New York, New York, USA
    FASEB J 18:373-5. 2004
    ..British and Danish neurodegenerative disorders are generated by processing mutant forms of the precursor protein BRI2. Although the pathogenic process that leads to deposition of amyloid in the brains of patients has been studied ..
  5. ncbi The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production
    Shuji Matsuda
    Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Biol Chem 280:28912-6. 2005
    ..Here, we show that BRI2, a type II membrane protein, interacts with A(beta)PP...
  6. ncbi BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production
    Angeliki Fotinopoulou
    Division of Animal and Human Physiology, Department of Biology, National and Kapodistrian University of Athens, 157 84 Panepistimiopolis, Ilisia, Athens, Greece
    J Biol Chem 280:30768-72. 2005
    Transmembrane proteins BRI2 and amyloid precursor protein (APP) co-localize with amyloid beta (Abeta) lesions in sporadic Alzheimer disease and mutations in both precursor proteins are linked to early-onset familial cases of cerebral ..
  7. ncbi Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b
    Lucas Martin
    Center for Integrated Protein Science Munich and Adolf Butenandt Institute, Department of Biochemistry, Laboratory for Neurodegenerative Disease Research, Ludwig Maximilians University, 80336 Munich, Germany
    J Biol Chem 283:1644-52. 2008
    ..Here we demonstrate that Bri2 (Itm2b), a type II-oriented transmembrane protein associated with familial British and Danish dementia, undergoes ..
  8. doi Substrate requirements for SPPL2b-dependent regulated intramembrane proteolysis
    Lucas Martin
    Center for Integrated Protein Science Munich and Adolf Butenandt Institute, Department of Biochemistry, Laboratory for Neurodegenerative Disease Research, Ludwig Maximilians University, 80336 Munich, Germany
    J Biol Chem 284:5662-70. 2009
    ..We demonstrate that similar to gamma-secretase substrates, intramembrane proteolysis of Bri2 (Itm2b) is greatly facilitated by an initial shedding event mediated by ADAM-10...
  9. pmc BRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2
    Shuji Matsuda
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 1046, USA
    J Biol Chem 284:15815-25. 2009
    ..we show that BRI3, a member of the BRI gene family that includes the familial British and Danish dementia gene BRI2, interacts with APP and serves as an endogenous negative regulator of Abeta production...
  10. pmc Memory deficits due to familial British dementia BRI2 mutation are caused by loss of BRI2 function rather than amyloidosis
    Robert Tamayev
    Department of Microbiology and Immunology, Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 30:14915-24. 2010
    ..FBD is caused by a missense mutation at the stop codon of the BRI2 gene (Vidal et al...
  11. pmc APP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutant
    Robert Tamayev
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA
    EMBO J 30:2501-9. 2011
    An autosomal dominant mutation in the BRI2/ITM2B gene causes familial Danish dementia (FDD)...
  12. ncbi Expression of BRI, the normal precursor of the amyloid protein of familial British dementia, in human brain
    Haruhiko Akiyama
    Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya Ku, 156 8585, Tokyo, Japan
    Acta Neuropathol 107:53-8. 2004
    ..British dementia (FBD) is characterized neuropathologically by deposition of a unique amyloid-forming protein, ABri. It is a fragment of an abnormal form of a precursor protein, BRI...
  13. ncbi [Hereditary cerebral amyloid angiopathies]
    F Gray
    Laboratoire de Neuropathologie, Hopital Raymond Poincare, Paris
    Rev Neurol (Paris) 157:1207-17. 2001
    ..g. beta-amyloid, cystatin C, transthyretin, gelsolin, amyloid protein Bri, prion protein)...
  14. pmc Giant syncytia and virus-like particles in ovarian carcinoma cells isolated from ascites fluid
    E M Rakowicz-Szulczynska
    Departments of Obstetrics and Gynecology, University of Nebraska Medical Center, Omaha, Nebraska 68198 3255, USA
    Clin Diagn Lab Immunol 6:115-26. 1999
    ..stained with an anti-human immunodeficiency virus type 1 (HIV-1) gp120 monoclonal antibody (MAb) and MAb RAK-BrI. Both MAbs recognized cancer-associated antigens RAK (for Rakowicz markers) p120, p42, and p25...
  15. doi Identification of heat shock protein 5, calnexin and integral membrane protein 2B as Adam7-interacting membrane proteins in mouse sperm
    Cecil Han
    School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, Korea
    J Cell Physiol 226:1186-95. 2011
    ..analysis revealed that Adam7 forms complexes with calnexin (Canx), heat shock protein 5 (Hspa5), and integral membrane protein 2B (Itm2b)...
  16. ncbi Differential expression and regulation of integral membrane protein 2b in rat male reproductive tissues
    Deivendran Rengaraj
    College of Life Science, Xiamen University, Xiamen 361005, China
    Asian J Androl 10:503-11. 2008
    To examine the expression and regulation of integral membrane protein 2b (Itm2b) in rat male reproductive tissues during sexual maturation and under different treatments by in situ hybridization.
  17. pmc Bile reflux index after therapeutic biliary procedures
    Sedef Kuran
    Gastroenterology Department, Turkiye Yuksek Ihtisas Hospital, Ankara, Turkey
    BMC Gastroenterol 8:4. 2008
    ..Patients are potential "bile refluxers". The aim of this study was to assess how these procedures affect the histology-based bile reflux index (BRI), which can be used to reflect duodenogastric reflux (DGR).
  18. ncbi Cerebral amyloid angiopathies: a pathologic, biochemical, and genetic view
    Tamas Revesz
    Queen Square Brain Bank, Department of Molecular Neuroscience and Division of Neuropathology, Institute of Neurology, University College London, London, United Kingdom
    J Neuropathol Exp Neurol 62:885-98. 2003
    ..of the Gerstmann-Sträussler-Scheinker syndrome, and 5) ABri and ADan in CAAs observed in the recently described BRI2 gene-related dementias, familial British dementia and familial Danish dementia, respectively...
  19. ncbi Cerebral amyloid angiopathy and gene polymorphisms
    Masahito Yamada
    Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, 13 1, Takara machi, Kanazawa 920 8640, Japan
    J Neurol Sci 226:41-4. 2004
    ..in association with various amyloid proteins including amyloid beta protein (Abeta), cystatin C, prion protein, ABri/ADan, transthyretin, and gelsolin...
  20. ncbi Trabeculectomy with mitomycin-C in the treatment of pediatric glaucomas
    P A Sidoti
    Department of Ophthalmology, The New York Eye and Ear Infirmary, New York 10003, USA
    Ophthalmology 107:422-9. 2000
    ..To evaluate the effectiveness and safety of trabeculectomy with mitomycin-C (MMC) in the management of childhood glaucomas...
  21. doi Herbal formula FBD extracts prevented brain injury and inflammation induced by cerebral ischemia-reperfusion
    Zhihong Lin
    Department of Chinese Medicinal Prescription, China Pharmaceutical University, Nanjing, PR China
    J Ethnopharmacol 118:140-7. 2008
    The aim of this work was to verify neuroprotective and anti-inflammatory properties of FBD, a herbal formula composed of Poria cocos, Atractylodes macrocephala and Angelica sinensis, in ICR mice subjected to repetitive 10 min of common ..
  22. pmc Bile reflux gastritis and intestinal metaplasia at the cardia
    M F Dixon
    Academic Unit of Pathology, University of Leeds, UK
    Gut 51:351-5. 2002
    ..reflux brings about histological changes in the gastric mucosa that can be graded and used to calculate a bile reflux index (BRI). We used the BRI to assess whether reflux of bile plays a part in the development of cardia IM.
  23. pmc Investigation of three new mouse mammary tumor cell lines as models for transforming growth factor (TGF)-beta and Neu pathway signaling studies: identification of a novel model for TGF-beta-induced epithelial-to-mesenchymal transition
    Anne E G Lenferink
    Receptor, Signaling and Proteomics Group, National Research Council, Biotechnology Research Institute, Montreal, Quebec, Canada
    Breast Cancer Res 6:R514-30. 2004
    ..mouse mammary tumor virus)/activated Neu + TbetaRII-AS (transforming growth factor [TGF]-beta type II receptor antisense RNA) bigenic mice (BRI-JM01 and BRI-JM05 cell lines) and MMTV/activated Neu transgenic mice (BRI-JM04 cell line).
  24. ncbi Sporadic and familial cerebral amyloid angiopathies
    Tamas Revesz
    Queen Square Brain Bank, Department of Molecular Pathogenesis, University College London, UK
    Brain Pathol 12:343-57. 2002
    ..meningo-vascular amyloidoses, gelsolin as well as familial prion disease-related CAAs and the recently described BRI2 gene-related CAAs in familial British dementia and familial Danish dementia...
  25. doi The clinical course of postinfectious irritable bowel syndrome: a five-year follow-up study
    In Su Jung
    Department of Internal Medicine, Yonsei Institute of Gastroenterology, Yongdong Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
    J Clin Gastroenterol 43:534-40. 2009
    ..Bacterial gastroenteritis has been known to be a risk factor for IBS. We investigated the clinical course, risk factors, and prognosis of postinfectious IBS (PI-IBS) 5 years after Shigella infection...
  26. ncbi Cerebral amyloid angiopathy: an overview
    M Yamada
    Department of Neurology, Kanazawa University School of Medicine, Japan
    Neuropathology 20:8-22. 2000
    ..amyloid beta-protein (Abeta), cystatin C (ACys), prion protein (AScr), transthyretin (ATTR), gelsolin (AGel), and ABri (or A-WD)) have been identified, leading to the classification of several types of CAA...
  27. pmc Cerebral amyloid angiopathy and parenchymal amyloid deposition in transgenic mice expressing the Danish mutant form of human BRI2
    Ruben Vidal
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Brain Pathol 19:58-68. 2009
    ..FDD is caused by a 10-nucleotide duplication-insertion in the BRI(2) gene that generates a larger-than-normal precursor protein, of which the Danish amyloid subunit (ADan) comprises ..
  28. doi Isolation of small-sized human epidermal progenitor/stem cells by Gravity Assisted Cell Sorting (GACS)
    Yasushi Fujimori
    Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI 48109 0654, USA
    J Dermatol Sci 56:181-7. 2009
    ..Small diameter characterizes epidermal progenitor/stem cells. We have developed Gravity Assisted Cell Sorting (GACS) to simply enrich small-sized epidermal progenitor/stem cells...
  29. ncbi Symptom patterns and relative distribution of functional bowel disorders in 1,023 gastroenterology patients in Iran
    Delnaz Roshandel
    Research Center for Gastroenterology and Liver Diseases, Shaheed Beheshti University of Medical Sciences, Taleghani Hospital, Parvaneh Street, Velenjak, Tehran, Iran
    Int J Colorectal Dis 21:814-25. 2006
    There are scanty data on functional bowel disorder (FBD) patterns in Iran. This first-time study tried to provide preliminary data on relative distribution of different types of FBD and their symptom patterns in Iranian patients.
  30. pmc Bile reflux gastritis and Barrett's oesophagus: further evidence of a role for duodenogastro-oesophageal reflux?
    M F Dixon
    Academic Unit of Pathology, University of Leeds, Leeds, UK
    Gut 49:359-63. 2001
    ..There is increasing evidence that reflux of bile plays a part in the pathogenesis of Barrett's oesophagus. Bile injury to the gastric mucosa results in a "chemical" gastritis in which oedema and intestinal metaplasia are prominent...
  31. doi A new approach to the diagnosis of children's urolithiasis based on the Bonn Risk Index
    Tadeusz Porowski
    First Department of Pediatrics, Medical University of Bialystok, Bialystok, Poland
    Pediatr Nephrol 23:1123-8. 2008
    ..The aims of this study were to determine CaOx crystallization using the Bonn Risk Index (BRI) in children with urolithiasis in comparison to healthy controls, to evaluate the relationships between BRI and ..
  32. ncbi ["Sick building syndrome"--a new problem of occupational medicine]
    T Wittczak
    Klinika Chorób Zawodowych Instytut Medycyny Pracy, Łódź
    Med Pr 52:369-73. 2001
    ..This term or another one "building-related illness" (BRI) is used to define illnesses related to non-industrial and non-residential buildings, mainly modern offices, in ..
  33. doi Pyroglutamate formation influences solubility and amyloidogenicity of amyloid peptides
    Dagmar Schlenzig
    Probiodrug AG, Weinbergweg 22, 06120 Halle Saale, Germany
    Biochemistry 48:7072-8. 2009
    ..Similarly, the deposited amyloid peptides ABri and ADan, which cause a very similar histopathology in familial British dementia (FBD) and familial Danish dementia ..
  34. doi Genetic diversity among Toxoplasma gondii isolates of small ruminants from Brazil: novel genotypes revealed
    Alessandra M A Ragozo
    Departamento de Medicina Veterinaria Preventiva e Saude Animal, Universidade de Sao Paulo, Av Prof Dr Orlando Marques de Paiva, 87, Cidade Universitaria, CEP 05508 270, Sao Paulo, SP, Brazil
    Vet Parasitol 170:307-12. 2010
    ..gondii isolates. Eight isolates (4 from sheep and 4 from goats) were grouped into the common clonal type BrI lineage. One sheep isolate was grouped to the type BrIII lineage...
  35. doi Expression of intracellular cytokines, HSP72, and apoptosis in monocyte subsets during exertional heat stress in trained and untrained individuals
    G A Selkirk
    Defence R and D Canada Toronto, 1133 Sheppard Ave E, Toronto, ON, Canada M3M 3B9
    Am J Physiol Regul Integr Comp Physiol 296:R575-86. 2009
    ..TNF-alpha, IL-1beta, IL-6, IL-1ra, and IL-10) in CD14(++)CD16(-)/CD14(+)CD16(+) and HSP72/apoptosis in CD14(Bri)/CD14(Dim) subsets. In addition, serum levels of extracellular (e)HSP72 were also examined...
  36. ncbi Familial British dementia: colocalization of furin and ABri amyloid
    Claudia Schwab
    Kinsmen Laboratory of Neurological Research, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada
    Acta Neuropathol 106:278-84. 2003
    ..The abnormal C-terminal fragment, ABri, accumulates in FBD in the form of extracellular amyloid deposits...
  37. ncbi Probing the relationship between interfacial concentrations and lipase activity in cationic W/O microemulsions: a quantitative study by chemical trapping
    Antara Dasgupta
    Department of Biological Chemistry and Center for Advanced Materials, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700032, India
    Langmuir 23:4137-43. 2007
    ..The interfacial concentrations of water ([H2Oi]), bromide ([Bri-]), and n-hexanol ([HexOHi]) were estimated in the W/O microemulsions of six surfactants with varying headgroup ..
  38. ncbi Automated measurement and calibration of reactive volatile halogenated organic compounds in the atmosphere
    David J Wevill
    Department of Chemistry, University of York, Heslington, York, YO10 5DD UK
    Analyst 129:634-8. 2004
    ..organic halocarbons CH(3)I, CHCl(3), C(2)H(5)I, 2-C(3)H(7)I, CH(2)Br(2), CH(2)ClI, CHBr(2)Cl, 1-C(3)H(7)I, CH(2)BrI, CHBr(3) and CH(2)I(2) for long term atmospheric field measurements are described...
  39. ncbi [Epidemiological study of functional bowel disorders in Iceland]
    Linda B Olafsdóttir
    Iceland University Hospital, Hringbraut, 101 Reykjavik, Iceland
    Laeknabladid 91:329-33. 2005
    The aim of the present study was to evaluate the prevalence of functional bowel disorders (FBD) in a population-based sample and to assess FBD-related health care seeking and medication in Iceland.
  40. ncbi Characterization of health related quality of life (HRQOL) for patients with functional bowel disorder (FBD) and its response to treatment
    Douglas Drossman
    The UNC Center for Functional GI and Motility Disorders, Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Am J Gastroenterol 102:1442-53. 2007
    ..little information is available on the performance of HRQOL questionnaires for the functional bowel disorders (FBD)...
  41. doi Detecting points as developmental delay based on the life-history development and urosome deformity of the harpacticoid copepod, Tigriopus japonicus sensu lato, following exposure to benzo(a)pyrene
    Hyun Woo Bang
    Division of Marine Technology, Chonnam National University, Yeosu 550 749, Republic of Korea
    Chemosphere 76:1435-9. 2009
    ..male emergence day (AMED), sex ratio (MER), brooding success rate (BSR), and first brooding day of adult females (FBD) were measured...
  42. pmc Between celiac disease and irritable bowel syndrome: the "no man's land" of gluten sensitivity
    Elena F Verdu
    Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Gastroenterol 104:1587-94. 2009
    ..It explores the hypothesis that, in a proportion of patients, GS causes functional bowel disorder (FBD)-like symptoms...
  43. ncbi Modulation of GDF5/BRI-b signalling through interaction with the tyrosine kinase receptor Ror2
    Marei Sammar
    Department of Physiological Chemistry, Biocenter, University of Wurzburg, Germany
    Genes Cells 9:1227-38. 2004
    ..of the BMP/TGF-beta ligand family, cause brachydactyly type C (BDC) whereas mutations in the receptor for GDF5, BRI-b, cause brachydactyly type A2 (BDA2)...
  44. ncbi [13q14 aberration is related to the metastatic potential of human NSCLC]
    Yun Huang
    Laboratory of Medical Genetics, Harbin Medical University, Harbin 150086, China
    Yi Chuan 27:531-4. 2005
    ..b>BRI gene showed different expression levels in the cell lines as revealed by mRNA differential display (mRNA DD) in the ..
  45. pmc CD74 interacts with APP and suppresses the production of Abeta
    Shuji Matsuda
    Albert Einstein College of Medicine, Department of Microbiology and Immunology, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Mol Neurodegener 4:41. 2009
    ..Abeta is cleaved off from amyloid precursor protein (APP) with consecutive proteolytic processing by beta-secretase and gamma-secretase...
  46. pmc Investigation of the effect of military stress on the prevalence of functional bowel disorders
    Xian Zhao Yu
    Department of Gastroenterology, General Hospital of Chinese People s Armed Police Forces, Beijing 100039, China
    World J Gastroenterol 18:3004-7. 2012
    To investigate the morbidity of functional bowel disorders (FBD) under military stress conditions in order to lay foundations for the prevention and treatment of this disease.
  47. ncbi Proteolytic processing of familial British dementia-associated BRI variants: evidence for enhanced intracellular accumulation of amyloidogenic peptides
    Seong Hun Kim
    Department of Neurobiology, Pharmacology and Physiology, The University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 277:1872-7. 2002
    ..The mutant genes encode BRI-L and BRI-D, the precursors of fibrillogenic ABri and ADan peptides, respectively...
  48. ncbi Laxative and anti-diarrheal activity of polycarbophil in mice and rats
    Takaharu Saito
    Research and Development Headquarters, Hokuriku Seiyaku, CO, Ltd, Katsuyama, Fukui, Japan
    Jpn J Pharmacol 89:133-41. 2002
    ..an insoluble hydrophilic polymer, in comparison with other agents used for treating functional bowel disorder (FBD). In naive rats, polycarbophil (500 mg/kg) increased fecal weight and water contents without producing diarrhea...
  49. ncbi Variability in the identification and enumeration of marine benthic invertebrate samples and its effect on benthic assessment measures
    J Ananda Ranasinghe
    Southern California Coastal Water Research Project, 7171 Fenwick Lane, Westminster, CA 92683 5218, USA
    Environ Monit Assess 81:199-206. 2003
    ..7%. Paired t-tests were used to test for differences in the Benthic Response Index (BRI), total abundance, numbers of taxa, and the Shannon-Wiener index between the original and the reanalysis data...
  50. ncbi Influence of ursodeoxycholate-enriched diet on liver tumor growth in HBV transgenic mice
    Michele Barone
    Section of Gastroenterology, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy
    Hepatology 37:880-6. 2003
    Hepatitis B virus (HBV) transgenic mice (official designation, Tg [Alb-1 HBV] Bri 44) invariably develop macroscopically evident tumors within the 20th month of life...
  51. ncbi Abnormal illness behaviour and locus of control in patients with functional bowel disorders
    I C A Hobbis
    General Practice and Primary Care Research Unit, Institute of Public Health, University of Cambridge, Cambridge, UK
    Br J Health Psychol 8:393-408. 2003
    Psychosocial factors have been examined in functional bowel disorders (FBD), including irritable bowel syndrome (IBS) and chronic idiopathic constipation (CIC)...
  52. ncbi Determination of the calcium oxalate crystallization risk from urine samples: the BONN Risk Index in comparison to other risk formulas
    Norbert Laube
    Division of Experimental Urology, Department of Urology, University of Bonn, Bonn, Germany
    J Urol 172:355-9. 2004
    ..We evaluated the BONN Risk Index (BRI) through data actualization and evaluation refinement...
  53. ncbi LPS regulates a set of genes in primary murine macrophages by antagonising CSF-1 action
    David P Sester
    Cooperative Research Centre for Chronic Inflammatory Diseases, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia
    Immunobiology 210:97-107. 2005
    ..By real time PCR we confirmed that the expression of a selection of these genes, including integral membrane protein 2B (itm2b), receptor activity-modifying protein 2 (ramp2) and macrophage-specific gene 1 (mpg-1), were ..
  54. pmc Genetic evidence for female-biased dispersal and gene flow in a polygynous primate
    Robert L Hammond
    Department of Ecology and Evolution, University of Lausanne, Biology Building, Lausanne 1015, Switzerland
    Proc Biol Sci 273:479-84. 2006
    ..all polygynous mammals show male-biased dispersal whereas largely monogamous birds show female-biased dispersal (FBD)...
  55. ncbi An oligodendroglial progenitor cell line FBD-102b possibly secretes a radial glia-inducing factor
    Makoto Horiuchi
    Department of Biological Science and Technology, and Tissue Engineering Research Center, Tokyo University of Science, 2641 Yamazaki, Noda City, Chiba 278 8510, Japan
    Neurosci Res 56:213-9. 2006
    Interactions between oligodendroglial and astroglial lineages during development are still unclear. In this study, FBD-102b, derived from p53-/- fetal brains, was characterized as an oligodendroglial progenitor cell (OPC) line...
  56. ncbi Biotechnological war against biofilms. Could phages mean the end of device-related infections?
    J L del Pozo
    Division of Infectious Diseases and Clinical Microbiology, Clinica Universitaria de Navarra, Pamplona, Spain
    Int J Artif Organs 30:805-12. 2007
    ..planktonic and sessile bacteria may relate to clinical failures in the treatment of biofilm-related infections (BRI)...
  57. ncbi Many drugs and phytochemicals can be activated to biological reactive intermediates
    William W Johnson
    Drug Metabolism and Pharmacokinetics, OSI Pharmaceuticals, Boulder, CO 80301, USA
    Curr Drug Metab 9:344-51. 2008
    ..Because any consequence of a biological reactive intermediate (BRI) is dependent on many factors a number of BRIs are benign...
  58. ncbi Dose-finding study of anti-CD25 antibody for targeting regulatory T cells in locoregional immunotherapy of malignant effusion
    Makoto Okawaki
    Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Kasumi 1 2 3, Minami hu, Hiroshima 734 8551, Japan
    Hiroshima J Med Sci 57:37-46. 2008
    ..We observed that a low concentration of 0.01 microg/ml basiliximab effectively targeted CD4+CD25(bri) Treg cells while preserving CD4+CD25(dim) activated T cells in vitro...
  59. pmc Complementary and alternative medicine use and cost in functional bowel disorders: a six month prospective study in a large HMO
    Miranda A L Van Tilburg
    Center for Functional Gastrointestinal and Motility Disorders, University of North Carolina, Chapel Hill, North Carolina, USA
    BMC Complement Altern Med 8:46. 2008
    Functional Bowel Disorders (FBD) are chronic disorders that are difficult to treat and manage...
  60. doi Enrichment of human beta 1 bri/alpha 6 bri/CD71 dim keratinocytes after culture in defined media
    Katrin Lorenz
    University of Leipzig, Biotechnological Biomedical Center, Department of Cell Techniques and Applied Stem Cell Biology, Leipzig, Germany
    Cells Tissues Organs 189:382-90. 2009
    ..In addition, the proportion of the alpha(6)(bri)/ CD71(dim)-expressing keratinocyte cell population was enhanced about 35.4 +/- 6...
  61. pmc Generation and initial characterization of FDD knock in mice
    Luca Giliberto
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA
    PLoS ONE 4:e7900. 2009
    Mutations in the integral membrane protein 2B, also known as BRI(2), a type II trans-membrane domain protein cause two autosomal dominant neurodegenerative diseases, Familial British and Danish Dementia...
  62. ncbi [Origins determination of Herba Abri cantoniensis and Herba Abri mollis with FTIR combined with fuzzy cluster and curve-fitting]
    Yi Bing Wang
    Lab of Biophysics, Guangxi Academy of Sciences, Nanning 530007, China
    Guang Pu Xue Yu Guang Pu Fen Xi 30:937-42. 2010
    The methods of fuzzy cluster and curve-fitting combined with FTIR were used to determine the origins of Herba Abri cantoniensis and Herba Abri mollis...
  63. pmc Danish dementia mice suggest that loss of function and not the amyloid cascade causes synaptic plasticity and memory deficits
    Robert Tamayev
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 107:20822-7. 2010
    ..FDD(KI/+) mice present reduced Bri2 levels, impaired synaptic plasticity and severe hippocampal memory deficits...
  64. doi Angiointervention: high rates of failure following blunt renal injuries
    Jay Menaker
    Department of Surgery, University of Maryland School of Medicine, Division Trauma Critical Care, R Adams Cowley Shock Trauma Center, 22 South Greene Street, T1R60, Baltimore, MD 21201, USA
    World J Surg 35:520-7. 2011
    ..Recently, angioembolization (AE) has been used to extend NOM. Few data exist on evaluating NOM of blunt renal injuries (BRIs). We sought to determine the overall efficacy of NOM as well as the outcome of AE in patients with BRI.
  65. doi Embedded-atom-method interatomic potentials from lattice inversion
    Xiao Jian Yuan
    Institute for Applied Physics, University of Science and Technology Beijing, Beijing, People s Republic of China
    J Phys Condens Matter 22:375503. 2010
    ..with the experimental data to the same extent as those calculated by other EAM-type potentials such as the FBD-EAM, 2NN MEAM and MS-EAM...
  66. doi BRICHOS domain associated with lung fibrosis, dementia and cancer--a chaperone that prevents amyloid fibril formation?
    Hanna Willander
    Department of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences, Uppsala, Sweden
    FEBS J 278:3893-904. 2011
    ..Today BRICHOS has been found in 12 protein families. Mutations in the Bri2 and proSP-C genes result in familial dementia and ILD, respectively, and both these conditions are associated with ..
  67. doi Economic burden attributable to functional bowel disorders in Iran: a cross-sectional population-based study
    Bijan Moghimi-Dehkordi
    Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Science, Tehran, Iran
    J Dig Dis 12:384-92. 2011
    While few population-based studies on the economic burden of functional bowel disorders (FBD) have been published from developing countries like Iran, this study aimed to estimate their direct and indirect costs for five groups of ..
  68. doi Optimized self nano-emulsifying systems of ezetimibe with enhanced bioavailability potential using long chain and medium chain triglycerides
    Shantanu Bandyopadhyay
    University Institute of Pharmaceutical Sciences UGC Centre of Advanced Studies, Panjab University, Chandigarh 160014, India
    Colloids Surf B Biointerfaces 100:50-61. 2012
    ..chain triglycerides (LCT's) and medium chain triglycerides (MCT's) of ezetimibe employing Formulation by Design (FbD), and evaluate their in vitro and in vivo performance...
  69. doi Chemical and biomarker responses for site-specific quality assessment of the Lake Maggiore (Northern Italy)
    Marco Parolini
    Department of Biosciences, University of Milan, Via Celoria 26, 20133, Milan, Italy
    Environ Sci Pollut Res Int 20:5545-57. 2013
    ..on chemical data, a suite of biomarkers and the integration of their responses into a biomarker response index (BRI) to evaluate the site-specific quality assessment in different sampling stations of Lake Maggiore, one of the ..
  70. doi Non-transference of biological reference interval of TSH by electrochemiluminescence immunoassay: an Indian population perspective
    Rajarshi Sarkar
    Department of Biochemistry, Drs Tribedi and Roy Diagnostic Laboratory Pvt Ltd 93 Park St, Kolkata 700016, India
    Clin Chim Acta 423:130-4. 2013
    ..been observed on interpretation of the test results when the manufacturer supplied biological reference interval (BRI) criteria were applied...
  71. doi The BRICHOS domain, amyloid fibril formation, and their relationship
    Stefan D Knight
    Department of Cell and Molecular Biology, Uppsala University, 751 05 Uppsala, Sweden
    Biochemistry 52:7523-31. 2013
    ..Recent data suggest that recombinant BRICHOS domains from proSP-C and Bri2 (associated with familial dementia and amyloid formation) interact with peptides with a strong propensity to form β..
  72. pmc Mitochondrial dysfunction induced by a post-translationally modified amyloid linked to a familial mutation in an alternative model of neurodegeneration
    Krysti Todd
    Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    Biochim Biophys Acta 1842:2457-67. 2014
    ..FBD is associated with a T to A single nucleotide transition in the stop codon of a gene encoding BRI2, leading to the production of an elongated precursor protein...
  73. doi Evaluation of U.S. Poison Center Data for Surveillance of Foodborne Disease
    Joann F Gruber
    1 Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina
    Foodborne Pathog Dis 12:467-78. 2015
    Enhancing foodborne disease (FBD) surveillance and improving the timeliness of outbreak detection have been identified as public health priorities...
  74. pmc Phytosulfokine Regulates Growth in Arabidopsis through a Response Module at the Plasma Membrane That Includes CYCLIC NUCLEOTIDE-GATED CHANNEL17, H+-ATPase, and BAK1
    Friederike Ladwig
    Universitat Tubingen, ZMBP, Plant Physiology, D 72076 Tubingen, Germany
    Plant Cell 27:1718-29. 2015
    ..directly with CNGC17, it interacts with the plasma membrane-localized H(+)-ATPases AHA1 and AHA2 and with the BRI-associated receptor kinase 1 (BAK1)...
  75. doi Assessment of personal occupational radiation exposures received by nuclear medicine and oncology staff in Punjab (2003-2012)
    T Zafar
    Department of Economics, Government College University, Lahore, Pakistan
    Australas Phys Eng Sci Med 38:473-8. 2015
    ..The Film Badge Dosimetry (FBD) technique has been utilized to process over 81,000 films (13,237 workers) concerning the occupationally exposed ..
  76. pmc A body shape index and body roundness index: two new body indices to identify diabetes mellitus among rural populations in northeast China
    Ye Chang
    Department of Cardiology, The First Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang, 110001, People s Republic of China
    BMC Public Health 15:794. 2015
    ..Recently, two new anthropometric indices, the A Body Shape Index (ABSI) and Body Roundness Index (BRI) have been developed as possible improved alternatives to BMI and WC...
  77. doi Skeletal preservation of children's remains in the archaeological record
    B M Manifold
    Derby, Derbyshire, United Kingdom Electronic address
    Homo 66:520-48. 2015
    ..using the anatomical preservation index (AP1), qualitative bone index (QBI) and the bone representation index (BRI). Also the presence of natural and artificial taphonomic processes was recorded for each skeleton...
  78. doi Simultaneous Detection of Flavonoids, Phenolic Acids and Alkaloids in Abri Herba and Abri Mollis Herba using Liquid Chromatography Tandem Mass Spectrometry
    Wenying Yan
    Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, P R China
    Phytochem Anal 27:50-6. 2016
    b>Abri Herba has remarkable properties, such as cleanup heat detoxification, dampness and activating blood circulation to dissipate blood stasis; as a result, it has been applied to treat acute or chronic hepatitis and mastitis...
  79. pmc Interaction of ApoE3 and ApoE4 isoforms with an ITM2b/BRI2 mutation linked to the Alzheimer disease-like Danish dementia: Effects on learning and memory
    Fabrizio Biundo
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States
    Neurobiol Learn Mem 126:18-30. 2015
    Mutations in Amyloid β Precursor Protein (APP) and in genes that regulate APP processing--such as PSEN1/2 and ITM2b/BRI2--cause familial dementia, such Familial Alzheimer disease (FAD), Familial Danish (FDD) and British (FBD) dementias...
  80. ncbi Structure and function of Fbxo7/PARK15 in Parkinson's disease
    Suzanne J Randle
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Curr Protein Pept Sci . 2016
    ..Parkinson's disease, and these are found within or near to its functional domains, including its F-box domain (FBD), its proline rich region (PRR), and its ubiquitin-like domain (Ubl)...
  81. doi Fluoroscopic balloon dilatation for anastomotic strictures in patients with esophageal atresia: A fifteen-year single centre UK experience
    Arimatias Raitio
    Department of Paediatric Surgery, Alder Hey Children s Hospital NHS Foundation Trust, Eaton Road, Liverpool L12 2AP, UK
    J Pediatr Surg 51:1426-8. 2016
    To assess the safety and effectiveness of fluoroscopic balloon dilatation (FBD) in children with esophageal anastomotic stricture after surgical repair of esophageal atresia.
  82. ncbi Psychological needs of patients with functional bowel disorder
    Rosie Odhuba
    Pain Management Department, St Peter s Hospital, Surrey
    Nurs Stand 26:35-40. 2011
    Psychological processes have an important role in functional bowel disorder (FBD), with a high incidence of psychological distress experienced by this patient group...
  83. ncbi Cytological behaviour of floral organs and in silico characterization of differentially expressed transcript-derived fragments associated with 'floral bud distortion' in soybean
    Prashant B Kale
    Biotechnology Centre, Post graduate Institute, Dr Panjabrao Deshmukh Krishi Vidyapeeth, Akola 444 104, India
    J Genet 95:787-799. 2016
    An attempt was made to understand the 'floral bud distortion' (FBD), an unexplored disorder prevailing in soybean...
  84. pmc Therapeutic Modulation of Gut Microbiota in Functional Bowel Disorders
    Hyo Jeong Lee
    Health Screening and Promotion Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    J Neurogastroenterol Motil 23:9-19. 2017
    ..irritable bowel syndrome, functional bloating, functional constipation, functional diarrhea, and unspecified FBD. Increasing evidence has emerged of late that intestinal microbiota is involved in the pathogenesis of FBDs...
  85. ncbi Clinical response to tricyclic antidepressants in functional bowel disorders is not related to dosage
    Albena Halpert
    UNC Center for Functional GI and Motility Disorders, Chapel Hill, North Carolina, USA
    Am J Gastroenterol 100:664-71. 2005
    ..Desipramine (DES) is effective over placebo (PLA) in treating moderate-to-severe functional bowel disorders (FBD)...
  86. ncbi Insulin-degrading enzyme degrades amyloid peptides associated with British and Danish familial dementia
    Laura Morelli
    Fundacion Instituto Leloir, Instituto de Investigaciones Bioquímicas de Buenos Aires, CONICET, Patricias Argentinas 435, Buenos Aires 1405, Argentina
    Biochem Biophys Res Commun 332:808-16. 2005
    ..defects cause the loss of the normal stop codon in the precursor BRI, generating novel 34-residue peptides named ABri and ADan in FBD and FDD, respectively...
  87. ncbi Molecular chaperons, amyloid and preamyloid lesions in the BRI2 gene-related dementias: a morphological study
    T Lashley
    Queen Square Brain Bank, Department of Molecular Neuroscience, Institute of Neurology, University College London, London, UK
    Neuropathol Appl Neurobiol 32:492-504. 2006
    ..In view of the similarities between AD and both familial British dementia (FBD) and familial Danish dementia (FDD), we investigated the presence of AAPs in these two diseases to understand ..
  88. ncbi [Sick building syndrome]
    Yoram Epstein
    Harefuah 147:607-8, 662. 2008
    ..Consequently, health problems related to this ecosystem have emerged. "Building-related illnesses" (BRI) refers to a group of illnesses with a fairly homogeneous clinical picture, objective abnormalities on clinical or ..
  89. pmc Benzothiazole aniline tetra(ethylene glycol) and 3-amino-1,2,4-triazole inhibit neuroprotection against amyloid peptides by catalase overexpression in vitro
    Amrutha Chilumuri
    Department of Human and Health Sciences and Department of Molecular and Applied Biosciences, Faculty of Science and Technology, University of Westminster, 115 New Cavendish Street, London W1W 6UW, United Kingdom
    ACS Chem Neurosci 4:1501-12. 2013
    ..the effects of catalase overexpression in SH-SY5Y neuronal cells on the toxicity of amyloid-β (Aβ), amyloid-Bri (ABri), amyloid-Dan (ADan), amylin (IAPP), and prion protein (PrP) peptides were determined...
  90. doi The familial dementia gene revisited: a missense mutation revealed by whole-exome sequencing identifies ITM2B as a candidate gene underlying a novel autosomal dominant retinal dystrophy in a large family
    Isabelle Audo
    INSERM, U968, Paris F 75012, France
    Hum Mol Genet 23:491-501. 2014
    ..Whole-exome sequencing identified a missense variant (c.782A>C, p.Glu261Ala) in ITM2B coding for Integral Membrane Protein 2B, which co-segregates with the disease in this large family and lies within the 24...
  91. pmc Deletion 16p13.11 uncovers NDE1 mutations on the non-deleted homolog and extends the spectrum of severe microcephaly to include fetal brain disruption
    Alex R Paciorkowski
    Departments of Neurology, Pediatrics, and Biomedical Genetics, Center for Neural Development and Disease, University of Rochester Medical Center, Rochester, NY 14642, USA
    Am J Med Genet A 161:1523-30. 2013
    ..patients with severe microcephaly, agenesis of the corpus callosum, scalp rugae, and a fetal brain disruption (FBD)-like phenotype with inherited deletions of 16p13.11...
  92. doi Preliminary data on a new opioid risk assessment measure: the Brief Risk Interview
    Ted Jones
    Behavioral Medicine Institute at Pain Consultants of East Tennessee, Knoxville, TN, USA
    J Opioid Manag 9:19-27. 2013
    ..and Opioid Assessment for Patients with Pain-Revised, and the new interview rating scale, the Brief Risk Interview (BRI)...
  93. doi Abdominal pain localization is associated with non-diarrheic Rome III functional gastrointestinal disorders
    M Bouchoucha
    Service de Physiologie, Universite Rene Descartes, Paris V, Paris, France
    Neurogastroenterol Motil 25:686-93. 2013
    Abdominal pain is common in patients with functional bowel disorders (FBDs). The aim of this study was to characterize the predominant sites of abdominal pain associated with FBD subtypes, as defined by the Rome III criteria.
  94. doi PCR-RFLP genotyping of Toxoplasma gondii from chickens from Espírito Santo state, Southeast region, Brazil: new genotypes and a new SAG3 marker allele
    H F J Pena
    Departamento de Medicina Veterinaria Preventiva e Saude Animal, Faculdade de Medicina Veterinaria e Zootecnia, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    Vet Parasitol 192:111-7. 2013
    ..Four isolates, distributed in four counties, corresponded to the Type BrI lineage, the genotype found most frequently in Brazil. No clonal Types I, II or III lineages were found...
  95. doi Female-biased dispersal in a bat with a female-defence mating strategy
    Martina Nagy
    Museum für Naturkunde, Leibniz Institute for Research on Evolution and Biodiversity, Invalidenstraße 43, D 10115, Berlin, Germany
    Mol Ecol 22:1733-45. 2013
    The ultimate causes for predominant male-biased dispersal (MBD) in mammals and female-biased dispersal (FBD) in birds are still subject to much debate...
  96. pmc Critical role for reactive oxygen species in apoptosis induction and cell migration inhibition by diallyl trisulfide, a cancer chemopreventive component of garlic
    Kumar Chandra-Kuntal
    Department of Pharmacology and Chemical Biology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, 2 32A Hillman Cancer Center Research Pavilion, 5117 Centre Avenue, Pittsburgh, PA 15213, USA
    Breast Cancer Res Treat 138:69-79. 2013
    ..MCF-7 and MDA-MB-231) and a cell line derived from spontaneously developing mammary tumor of a transgenic mouse (BRI-JM04) to DATS resulted in a dose-dependent inhibition of cell viability that was accompanied by apoptosis induction...
  97. ncbi [Bacteriostatic and/or bactericidal extract of Aloe vera gel on cultures of Listeria monocytogenes]
    Luis Guillermo Ramírez Mérida
    Departamento de Biologia, Facultad de Ciencias y Tecnologia, Escuela de Ciencias Biomédicas y Tecnológicas, Instituto de Investigaciones en Nutrición, Universidad de Carabobo, Sede Valencia, Venezuela
    Arch Latinoam Nutr 62:73-8. 2012
    Listeria monocytogenes is a bacteria responsible for food borne diseases (FBD)...
  98. pmc Abundant pyroglutamate-modified ABri and ADan peptides in extracellular and vascular amyloid deposits in familial British and Danish dementias
    Anika Saul
    Division of Molecular Psychiatry, Georg August University Goettingen, University Medicine Goettingen, Germany
    Neurobiol Aging 34:1416-25. 2013
    ..are progressive neurodegenerative disorders characterized by cerebral deposition of the amyloidogenic peptides ABri and ADan, respectively...
  99. pmc Inhibition of γ-secretase worsens memory deficits in a genetically congruous mouse model of Danish dementia
    Robert Tamayev
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Mol Neurodegener 7:19. 2012
    A mutation in the BRI2/ITM2b gene causes familial Danish dementia (FDD). BRI2 is an inhibitor of amyloid-β precursor protein (APP) processing, which is genetically linked to Alzheimer's disease (AD) pathogenesis...
  100. pmc Čerenkov radiation emission and excited luminescence (CREL) sensitivity during external beam radiation therapy: Monte Carlo and tissue oxygenation phantom studies
    Rongxiao Zhang
    Department of Physics and Astronomy, Dartmouth College, Hanover NH 03755, USA
    Biomed Opt Express 3:2381-94. 2012
    ..As the fiber-to-beam distance (FBD) varied from 0 to 30 mm, i.e...
  101. ncbi The relation of urinary Tamm-Horsfall-protein on CaOx-crystallization under the scope of the Bonn-Risk-Index
    N Laube
    Division of Experimental Urology, Department of Urology, Bonn University, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Urol Res 29:45-9. 2001
    In previous papers we introduced the Bonn-Risk Index (BRI) as a new method of evaluating an individual's actual risk of forming calcium oxalate (CaOx)...

Research Grants42

  1. JORGE A GHISO; Fiscal Year: 2014
    ..Notably, the amyloid subunits isolated from FBD deposits -ABri- and FDD lesions -ADan- are structurally unrelated to the Alzheimer's A[unreadable], a clear indication that ..
  2. Dementia due to mutations in BRI2;link to Alzheimer's Disease
    Robert Tamayev; Fiscal Year: 2011
    ..We postulated the existence of membrane proteins that bind APP and regulate its processing and have identified BRI2 as an APP ligand...
  3. Insulin/Insulin receptor modulate APP phosphorylation and dementia
    LUCIANO D'ADAMIO; Fiscal Year: 2013
    ..Familial Danish Dementia (FDD), an AD-like neurodegenerative disorders, is due to mutation in the BRI2/ITM2b gene. Interestingly, BRI2 is an inhibitor of APP processing...
  4. Cerebral Amyloidosis and Dementia
    JORGE A GHISO; Fiscal Year: 2013
    ..The deposited proteins (ABri in FBD and ADan in FDD), nevertheless, differ from AB in length and in primary structure and yet, all species share ..
  5. Rachel M Ceballos; Fiscal Year: 2015
    ..program will include participation in the FHCRC and University of Washington Biomedical Research Integrity (BRI) Series, online training in the responsible conduct of research, and formal coursework in Social and Ethical Issues ..
  6. LUCIANO D'ADAMIO; Fiscal Year: 2015
    ..Familial Danish Dementia (FDD), an AD-like neurodegenerative disorders, is due to mutation in the BRI2/ITM2b gene. Interestingly, BRI2 is an inhibitor of APP processing...
  7. Jeffrey A Jones; Fiscal Year: 2016
    ..Examination of the TGF-b signaling pathway during TAA development revealed a shift in signaling from a TGF-bRI-mediated pathway to an ALK-1- mediated pathway...
  8. Thomas M Wisniewski; Fiscal Year: 2016
    ..We hypothesized that through "conformational mimicry" the polymerized ABri peptide could induce a conformation selective immune response that will recognize both A[unreadable] and ..
  9. Effect of sereted AB40 on the cognitive function in neurodegenerative disease
    Naruhiko Sahara; Fiscal Year: 2010
    ..An AAV construct expressing A[unreadable]40 or A[unreadable]42 peptide fused to the C-terminal end of the BRI protein will be utilized so that we can focus our studies specifically on the A[unreadable]40 or A[unreadable]42 ..
  10. Shivendra Singh; Fiscal Year: 2016
    ..aims of this project are to: (1) Determine the mechanism of WA-mediated ROS production using MDA-MB-231, MCF-7, BRI-JM04, and MCF-10A cell lines as a model;(2) Determine the mechanism of WA-mediated activation of JNK1/2 using the ..
  11. The Biochemistry and Physiology of Platelet TFPI
    SUSAN ANTONE MARONEY; Fiscal Year: 2013
    ..Continuous interactions with basic scientists at the Blood Research Institute (BRI) of the Blood Center of Wisconsin and the Medical College of Wisconsin will provide 1) access to experienced ..
  12. Carole Ober; Fiscal Year: 2015
    ..YKL-40, fractional exhaled nitric oxide (eNO), %predicted FEV1, FEV1/FVC ratio, and bronchial responsiveness index (BRI). We propose to identify genes that are differentially expressed in Hutterites with high vs...
  13. Providing Core Support for Jr. Faculty for Translational Research in ASD
    Daniel H Geschwind; Fiscal Year: 2010
    ..center across the large, highly collaborative UCLA neuroscience community overseen by the Brain Research Institute (BRI) and the UCLA medical center...
  14. C. Elegans Model for Neurodegenerative Diseases of Aging
    Richard I Morimoto; Fiscal Year: 2010
    ..proteins (Androgen Receptor, Ataxin-3, Huntingtin, mutant SOD1, A2 and related amyloidogenic proteins ADan and ABri, and yeast prions (Sup35)...
  15. The Science of Medicare Reform
    DANA P contact GOLDMAN; Fiscal Year: 2010
    ..Medicare Part D market;2) Understand competition in the Medicare Part D marketplace;3) Examine the consequences of FBD for utilization, health, and spending;4) Apply comparative effectiveness analysis to identify clinical areas for ..
  16. LUCIANO D'ADAMIO; Fiscal Year: 2016
    ..Given the role of APP processing in AD and APP-mediated functions, modulators of APP cleavage such as BRI2 are biologically relevant and of therapeutic interest...
  17. EARLY DETECTION OF URINARY BLADDER CANCER
    Bogdan Czerniak; Fiscal Year: 2009
    ..of studies: (1) Perform functional analyses and assessment of the already identified putative "forerunner genes" (ITM2B, P2RY5, and CHClL) located contiguously to RB1 as novel early detection biomarkers...
  18. Richard I Morimoto; Fiscal Year: 2016
    ..Androgen Receptor, Ataxin-3, Huntingtin, mutant SOD1, A[unreadable] and related amyloidogenic proteins ADan and ABri, and yeast prions (Sup35)...
  19. Intestinal Dendritic Cell Modulation of Regulatory T Cell Function in IBD
    JAMES DANIEL LORD; Fiscal Year: 2012
    ..is well equipped for molecular and cellular immunology research, and exists within the Benaroya Research Institute (BRI)...
  20. Parvin Building Animal Resources Center Improvement Plan
    Richard W Ermel; Fiscal Year: 2013
    ..for animal models used in breeding and research activities at the Beckman Research Institute of City of Hope (COH/BRI) and will substantially optimize space utilization at the Division of Comparative Medicine within the centralized ..
  21. Initiative in Stem Cell Biology
    Gilbert C White; Fiscal Year: 2010
    ..goal of this application is to convert shelled space in BloodCenter of Wisconsin's Blood Research Institute (BRI) into finished laboratory space in order to grow the Stem Cell Program at the BRI...
  22. HEPARIN INDUCED THROMBOCYTOPENIA/THROMBOSIS
    GIAN VISENTIN; Fiscal Year: 2000
    ..The Blood Research Institute (BRI) houses a family of core support laboratories and a group of investigators with diverse interests who can provide ..
  23. Phenotypic Changes Underlying Visceral Hypersensitivity in a Mouse Model of IBs
    JULIE A CARLSTEN CHRISTIANSON; Fiscal Year: 2010
    ..diseases, pain is often the first warning of organ dysfunction;however, in functional bowel disorders (FBD), like irritable bowel syndrome (IBS), pain is the main debilitating aspect of the condition...
  24. Michael Mack; Fiscal Year: 2015
    ..Baylor Research Institute and the Cardiopulmonary Research Science and Technology Institute formed a consortium (BRI-CRSTI) consisting of 2 research institutes and the 3 largest cardiac surgery programs in the Dallas-Fort Worth ..
  25. Multimedia Motivational Interviewing Training for Physical Therapists
    ROBIN INLANDER; Fiscal Year: 2007
    ..In this Phase I, Small Business Innovative Research (SBIR) proposal, Behavioral Research, Incorporated, (BRI) seeks to design and develop a prototype for a computer-based, multimedia, interactive, educational program to ..
  26. Rapid Assessment for Drug Abuse and Risky Sex (RADARS)
    ROBIN INLANDER; Fiscal Year: 2010
    The goal of the Phase II, Behavioral Research, Inc. (BRI), Rapid Assessment for Drug Abuse and Risky Sex (RADARS) is to create a fully functioning program that: addresses the need for a rapid, computer-based assessment for sexual and ..
  27. MULTICENTER TRIAL OF FUNCTIONAL BOWEL DISORDERS
    Douglas Drossman; Fiscal Year: 2001
    ..is to compare the efficacies of clinical treatments for the group of chronic, painful functional bowel disorders (FBD) that predominantly affect women...
  28. AMYLOID ANGIOPATHY, EARLY PLAQUES & AGING
    Blas Frangione; Fiscal Year: 2003
    ..Degradation of the carboxyl-end of this abnormal precursor molecule releases a 34 amino acid amyloid peptide (ABri) found deposited in vascular and parenchymal plaques in patients with FBD...
  29. Capillary DNA Sequencer/Genetic Analyzer
    LESTER CASHDOLLAR; Fiscal Year: 2003
    The Blood Research Institute (BRI) of The Blood Center of Southeastern Wisconsin has an established, long-term commitment to blood-related research...
  30. Transgenic Mice Depositing Individual AB peptides
    Eileen McGowan; Fiscal Year: 2006
    ..peptides are efficiently expressed and secreted without APP overexpression, we created transgenic mice that express BRI-Abeta, fusion proteins...
  31. Research Irradiator
    LESTER CASHDOLLAR; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): The Blood Research Institute (BRI) of The Blood Center of Southeastern Wisconsin has an established, long-term commitment to blood-related research...
  32. ORGANIZATION OF THE PATHWAY OF UREA SYNTHESIS IN SITU
    Natalie Cohen; Fiscal Year: 1993
    ..will be used to locate the cytoplasmic urea cycle enzymes in intact and permeabilized hepatocytes, and possibly in Bri j-treated and "nude" hepatocytes...
  33. Bruker Biospec 9.4T/40cm Bore MRI System
    Shi Jiang Li; Fiscal Year: 2002
    ..The NCRR-SIG will be administered by the MCW Biophysics Research Institute (BRI) in alliance with the college's Cancer Center and the Human and Molecular Genetics Center...
  34. Sympathetic-Immune Interface: Central Sites & Function
    MICHAEL KENNEY; Fiscal Year: 2005
    ..Ultimately, these findings may allow for the design of intervention strategies in immune regulation fostering robust and appropriate communication between the immune and nervous systems. ..
  35. SENESCENCE ALTERS SYMPATHETIC REGULATION TO HEAT STRESS
    MICHAEL KENNEY; Fiscal Year: 2004
    ..The proposed studies will, for the first time, advance the hypothesis that the working strategies employed by sympathetic neural circuits to respond to heat stress are modified by aging. ..
  36. Expression and function of ABCA3 in Type 2 cells
    MICHAEL FRANCIS BEERS; Fiscal Year: 2010
    ....
  37. Models of P. carinii Infection: SP-A and SP-D null mice
    Michael Beers; Fiscal Year: 2009
    ....
  38. Novel Animal Models of Familial British, Danish and Alzheimer's Dementia
    LUCIANO D ADAMIO; Fiscal Year: 2007
    ..We have recently identified as a putative APP ligand BRI2, a protein found mutated in patients with Familial British and Danish Dementia (FBD and FDD), two diseases ..
  39. Cellular signaling and Trafficking of APP Family Members
    LUCIANO D ADAMIO; Fiscal Year: 2007
    ..These studies may clarify the biological role of APP family members and have important practical applications in the development of new compounds for the cure and or prevention of Alzheimer's disease. ..
  40. SURFACTANT METABOLISM IN PNEUMOCYSTIS CARINII PNEUMONIA
    Michael Beers; Fiscal Year: 2002
    ..A co-investigator experienced with P. carinii biology and gpA purification; 3. Consultants recognized as authorities on the scid mouse model of PCP and on isolated lung perfusion. ..
  41. Signaling Function by APP Processing and Release of AID
    LUCIANO D ADAMIO; Fiscal Year: 2006
    ..Lastly, regulation of APP endocytosis and processing by Numb/Nbl proteins might provide potential new targets for compounds aimed to reduce Abeta production. ..
  42. Surfactant Protein C Mutations:Interstitial Lung Disease
    Michael Beers; Fiscal Year: 2006
    ..unreadable] [unreadable]..