ITGB6

Summary

Gene Symbol: ITGB6
Description: integrin subunit beta 6
Alias: AI1H, integrin beta-6, integrin, beta 6
Species: human

Top Publications

  1. ncbi The integrin alphaVbeta6 binds and activates latent TGFbeta3
    Justin P Annes
    Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    FEBS Lett 511:65-8. 2002
  2. ncbi Alphavbeta6-Fyn signaling promotes oral cancer progression
    Xiaowu Li
    Department of Stomatology, University of California San Francisco, San Francisco, CA 94143 0512, USA
    J Biol Chem 278:41646-53. 2003
  3. ncbi The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis
    J S Munger
    Department of Medicine, and Kaplan Cancer Center, New York University School of Medicine, New York 10016 6402, USA
    Cell 96:319-28. 1999
  4. ncbi Complete amino acid sequence of a novel integrin beta subunit (beta 6) identified in epithelial cells using the polymerase chain reaction
    D Sheppard
    Lung Biology Center, San Francisco, CA 94143
    J Biol Chem 265:11502-7. 1990
  5. ncbi Significance of alpha 9 beta 1 and alpha v beta 6 integrin expression in breast carcinoma
    K Arihiro
    Second Department of Pathology, Hiroshima University School of Medicine, Japan
    Breast Cancer 7:19-26. 2000
  6. pmc Fusion of epithelial cells by Epstein-Barr virus proteins is triggered by binding of viral glycoproteins gHgL to integrins alphavbeta6 or alphavbeta8
    Liudmila S Chesnokova
    Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    Proc Natl Acad Sci U S A 106:20464-9. 2009
  7. ncbi The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes
    V Wixler
    Institute for Biochemistry II, Medical Faculty, University of Cologne, Joseph Stelzmann Strasse 52, 50931 Cologne, Germany
    J Biol Chem 275:33669-78. 2000
  8. ncbi Direct integrin alphavbeta6-ERK binding: implications for tumour growth
    Nuzhat Ahmed
    Gynaecological Cancer Research Centre, The Royal Women s Hospital, Melbourne and University of Melbourne, Melbourne, Australia
    Oncogene 21:1370-80. 2002
  9. ncbi Inhibition of human immunodeficiency virus type 1 infection in macrophages by an alpha-v integrin blocking antibody
    Berta Bosch
    Fundacio irsiCaixa, Laboratori de Retrovirologia, Hospital Universitari Germans Trias i Pujol, Universitat Autonoma de Barcelona, Ctra del Canyet s n, 08916 Badalona, Spain
    Antiviral Res 69:173-80. 2006
  10. doi Alphavbeta6 is required in maintaining the intestinal epithelial barrier function
    Yong Yu
    Department of Gastroenterology, The Second Hospital, Zhengzhou University, Zhengzhou, China
    Cell Biol Int 38:777-81. 2014

Research Grants

  1. INITIATION OF CELL INFECTION BY EPSTEIN-BARR VIRUS
    Lindsey Hutt Fletcher; Fiscal Year: 2004
  2. Epstein-Barr virus glycoproteins and virus spread
    Lindsey Hutt Fletcher; Fiscal Year: 2009

Patents

  1. A NOVEL INTEGRIN beta SUBUNIT AND USES THEREOF

Scientific Experts

  • Jens Schittenhelm
  • D C Mash
  • Laura L Koth
  • J L Hecht
  • Lindsey M Hutt-Fletcher
  • Yasuyuki Yokosaki
  • Camilla S Bruun
  • Outi Heikkilä
  • Yoshifumi Arai
  • L J Arend
  • A V Ljubimov
  • L Qi
  • P F Ridgway
  • Lindsey Hutt Fletcher
  • Paul H Weinreb
  • Shelia M Violette
  • Dean Sheppard
  • Bradley P Sullivan
  • Jun Niu
  • G J Thomas
  • Gauri Saini
  • Amanda L Tatler
  • Joanne Porte
  • Gisli Jenkins
  • John F Marshall
  • Liudmila S Chesnokova
  • Robert Gelfand
  • Yanan Huo
  • Minxiao Yi
  • Bin Song
  • Krisha Desai
  • Javed Mohammed
  • Muhammad Ansar
  • Xiu ge Wang
  • C Eberlein
  • Ying Jhen Su
  • Benjia Liang
  • Mingyan Xu
  • Martin Kolb
  • Elizabeth K Duperret
  • Wentong Li
  • Liu Enyu
  • John S Munger
  • Lisa Jolly
  • Michael D Allen
  • Shih Kai Wang
  • Wasim Ahmad
  • Yong Yu
  • James A Poulter
  • Akira Ishikawa
  • Rani Singh
  • J F Marshall
  • Hai Xia Li
  • Tatiana Gianni
  • Huiling Guo
  • Adam V Jones
  • Regina T Mukhametshina
  • Ping Chang Yang
  • Baoyao Xue
  • Leila Mohazab
  • K S Famulski
  • Shao bo Yang
  • Aram F Hezel
  • Candy N Lee
  • Bushra Khan
  • Lari Hakkinen
  • Anelise Klein
  • I Fernandez-Cadenas
  • Horia C Stanescu
  • Céline Defilles
  • M R Morgan
  • James P Luyendyk
  • Hu Ding
  • Dana A Massuto
  • Jane L Wagstaff
  • Shinichi Takatsuki
  • Jani Seitsonen
  • Rui Zhao
  • Jasper N Jacobsen
  • Elissa Wilker
  • Marie Pierre Montero
  • Michael V Agrez
  • Sven H Hausner
  • L F Yap
  • Poshala Aluwihare
  • Zhicheng Zhao
  • Gerald S Horan
  • Yury Popov
  • Takako Tabata
  • Nuzhat Ahmed

Detail Information

Publications105 found, 100 shown here

  1. ncbi The integrin alphaVbeta6 binds and activates latent TGFbeta3
    Justin P Annes
    Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    FEBS Lett 511:65-8. 2002
    ..In particular, the extent to which activation mechanisms differ among the three TGFbeta isoforms is relatively unexplored. We show here that alphaVbeta6 binds and activates latent TGFbeta3...
  2. ncbi Alphavbeta6-Fyn signaling promotes oral cancer progression
    Xiaowu Li
    Department of Stomatology, University of California San Francisco, San Francisco, CA 94143 0512, USA
    J Biol Chem 278:41646-53. 2003
    ..These findings indicate that integrin beta6 signaling activates Fyn and thus promotes oral cancer progression...
  3. ncbi The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis
    J S Munger
    Department of Medicine, and Kaplan Cancer Center, New York University School of Medicine, New York 10016 6402, USA
    Cell 96:319-28. 1999
    ..These data identify a novel mechanism for locally regulating TGF beta 1 function in vivo by regulating expression of the alpha v beta 6 integrin...
  4. ncbi Complete amino acid sequence of a novel integrin beta subunit (beta 6) identified in epithelial cells using the polymerase chain reaction
    D Sheppard
    Lung Biology Center, San Francisco, CA 94143
    J Biol Chem 265:11502-7. 1990
    ..Because this protein is clearly distinct from the two other recently described integrins beta 4 and beta 5, we propose to designate it beta 6...
  5. ncbi Significance of alpha 9 beta 1 and alpha v beta 6 integrin expression in breast carcinoma
    K Arihiro
    Second Department of Pathology, Hiroshima University School of Medicine, Japan
    Breast Cancer 7:19-26. 2000
    ..As for the ligands of alpha v beta 6, fibronectin and tenascin-C have been identified. It has not been ascertained whether alpha 9 beta 1 and alpha v beta 6 are expressed in normal breast tissue, benign breast lesion or breast carcinoma...
  6. pmc Fusion of epithelial cells by Epstein-Barr virus proteins is triggered by binding of viral glycoproteins gHgL to integrins alphavbeta6 or alphavbeta8
    Liudmila S Chesnokova
    Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    Proc Natl Acad Sci U S A 106:20464-9. 2009
    ..We conclude that the direct interaction between EBV gHgL and integrins alphavbeta6 and alphavbeta8 can provide the trigger for fusion of EBV with an epithelial cell...
  7. ncbi The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes
    V Wixler
    Institute for Biochemistry II, Medical Faculty, University of Cologne, Joseph Stelzmann Strasse 52, 50931 Cologne, Germany
    J Biol Chem 275:33669-78. 2000
    ..These results, together with the fact that full-length DRAL/FHL2 is found in cell adhesion complexes, suggest that it is an adaptor/docking protein involved in integrin signaling pathways...
  8. ncbi Direct integrin alphavbeta6-ERK binding: implications for tumour growth
    Nuzhat Ahmed
    Gynaecological Cancer Research Centre, The Royal Women s Hospital, Melbourne and University of Melbourne, Melbourne, Australia
    Oncogene 21:1370-80. 2002
    ..The physical interaction between integrin alphavbeta6 and ERK2 defines a novel paradigm of integrin-mediated signalling and provides a therapeutic target for cancer treatment...
  9. ncbi Inhibition of human immunodeficiency virus type 1 infection in macrophages by an alpha-v integrin blocking antibody
    Berta Bosch
    Fundacio irsiCaixa, Laboratori de Retrovirologia, Hospital Universitari Germans Trias i Pujol, Universitat Autonoma de Barcelona, Ctra del Canyet s n, 08916 Badalona, Spain
    Antiviral Res 69:173-80. 2006
    ....
  10. doi Alphavbeta6 is required in maintaining the intestinal epithelial barrier function
    Yong Yu
    Department of Gastroenterology, The Second Hospital, Zhengzhou University, Zhengzhou, China
    Cell Biol Int 38:777-81. 2014
    ..Addition of recombinant avb6 blocked increases in permeability of T84 monolayers to OVA induced by tumor necrosis factor-α. ..
  11. doi Integrinβ6-targeted immunoliposomes mediate tumor-specific drug delivery and enhance therapeutic efficacy in colon carcinoma
    Benjia Liang
    Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Jinan, Shandong, P R China Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Public Health, Jinan, Shandong, P R China
    Clin Cancer Res 21:1183-95. 2015
    ..Integrinβ6 (ITGB6) is expressed in malignant colonic epithelia, but not in normal epithelia, and is associated with the progression, ..
  12. doi Binding of MMP-9-degraded fibronectin to β6 integrin promotes invasion via the FAK-Src-related Erk1/2 and PI3K/Akt/Smad-1/5/8 pathways in breast cancer
    Wentong Li
    Department of Pathology, Weifang Medical University, Weifang, Shandong 261053, P R China
    Oncol Rep 34:1345-52. 2015
    ....
  13. pmc Focal-adhesion-independent integrin-αv regulation of FAK and c-Myc is necessary for 3D skin formation and tumor invasion
    Elizabeth K Duperret
    Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, BRB 1010, 421 Curie Blvd, Philadelphia, PA 19104, USA
    J Cell Sci 128:3997-4013. 2015
    ..depend only on the binding partners of integrin-αv--integrin β5 and integrin β6 (also known as ITGB5 and ITGB6, respectively)...
  14. doi Genetic variants in the ITGB6 gene is associated with the risk of radiation pneumonitis in lung cancer patients treated with thoracic radiation therapy
    Minxiao Yi
    Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, 430030, Hubei Province, China
    Tumour Biol 37:3469-77. 2016
    ..We hypothesized that polymorphisms in αvβ6 integrin genes (ITGAV and ITGB6) might be associated with the risk of radiation pneumonitis (RP) in lung cancer patients treated with thoracic ..
  15. pmc High expression of integrin β6 in association with the Rho-Rac pathway identifies a poor prognostic subgroup within HER2 amplified breast cancers
    Krisha Desai
    Division of Molecular Medicine, St John s Research Institute, Bangalore, India
    Cancer Med 5:2000-11. 2016
    ..In addition, integrin β6 (ITGB6) is of prognostic value in invasive breast cancers, particularly in HER2+ subtype...
  16. pmc Long-term exposure of MCF-7 breast cancer cells to ethanol stimulates oncogenic features
    Robert Gelfand
    Department of Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    Int J Oncol 50:49-65. 2017
    ..Long-term exposure upregulated expression of some malignancy related genes (STEAP4, SERPINA3, SAMD9, GDF15, KRT15, ITGB6, TP63, and PGR, as well as the CEACAM, interferon related, and HLA gene families)...
  17. ncbi Distribution of integrins alpha v beta 6 and alpha 9 beta 1 and their known ligands, fibronectin and tenascin, in human airways
    A Weinacker
    Lung Biology Center, University of California, San Francisco 94143, USA
    Am J Respir Cell Mol Biol 12:547-56. 1995
    ..These findings are compatible with the existence of as-yet unidentified ligands for each of these integrins--for example, ligands involved in homotypic cell-cell interactions within the epithelium...
  18. pmc Interaction of alphaVbeta3 and alphaVbeta6 integrins with human parechovirus 1
    Jani Seitsonen
    Department of Biosciences, Institute of Biotechnology, PO Box 65, Viikinkaari 1, FIN 00014 University of Helsinki, Finland
    J Virol 84:8509-19. 2010
    ..This first structural characterization of a parechovirus indicates that the differences in receptor binding are due to the amino acid differences in the integrins rather than to significantly different viral footprints...
  19. doi αv integrin processing interferes with the cross-talk between αvβ5/β6 and α2β1 integrins
    Céline Defilles
    INSERM, UMR 911, Centre de Recherche en Oncologie et Oncopharmacologie, F 13005 Marseille, France
    Biol Cell 103:519-29. 2011
    ..We previously demonstrated that αvβ5/β6 integrin represses α2β1-dependent cell migration. The αv subunits undergo an endoproteolytic cleavage by protein convertases, whose role in tumoral invasion has remained controversial...
  20. doi Integrin alphavbeta6 promotes tumor tolerance in colorectal cancer
    Shao bo Yang
    Department of Gastroenterology South Building, China PLA General Hospital, Beijing, People s Republic of China
    Cancer Immunol Immunother 61:335-42. 2012
    ..We conclude that CRC-derived avb6 is involved in the establishment of tumor immune tolerance in local tissues...
  21. doi Expression of αvβ6 integrin and collagen fibre in oral squamous cell carcinoma: association with clinical outcomes and prognostic implications
    Hai Xia Li
    Department of Anatomy, Basic Medical Science College, Harbin Medical University, Harbin, China
    J Oral Pathol Med 42:547-56. 2013
    ....
  22. doi Integrin alpha v beta 6 contributes to maintaining corneal epithelial barrier function
    Huiling Guo
    Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China Department of Ophthalmology, Chinese PLA 306 Hospital, Beijing, China
    Cell Biol Int 37:593-9. 2013
    ..We conclude that the integrin avb6 plays an important role in the fusion of endosome/lysosome in corneal epithelial cells; inhibition of avb6 results in corneal epithelial barrier dysfunction...
  23. doi Stromal cell-derived factor-1 (SDF-1) enhances cells invasion by αvβ6 integrin-mediated signaling in ovarian cancer
    Baoyao Xue
    Department of Obstetrics and Gynecology, Xijing Hospital, Fourth Military Medical University, Xi an 710032, China
    Mol Cell Biochem 380:177-84. 2013
    ..Consequently, our findings will provide a new explanation about how SDF-1 aggravates the pathogenesis of ovarian cancer...
  24. doi ADAM 10 is over expressed in oral squamous cell carcinoma and contributes to invasive behaviour through a functional association with αvβ6 integrin
    Adam V Jones
    Academic Unit of Oral and Maxillofacial Pathology, School of Clinical Dentistry, University of Sheffield, UK
    FEBS Lett 587:3529-34. 2013
    ..This may result from ADAM 10-induced up-regulation of MMPs. We conclude ADAM 10 may influence OSCC invasion by functionally interacting with αvβ6 integrin which we have previously shown is over expressed in OSCC. ..
  25. doi Altered microenvironment promotes progression of preinvasive breast cancer: myoepithelial expression of αvβ6 integrin in DCIS identifies high-risk patients and predicts recurrence
    Michael D Allen
    Authors Affiliations Barts Cancer Institute a CR UK Centre of Excellence, Centre for Tumour Biology, Queen Mary University of London, John Vane Science Centre Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, London, Cancer Research UK Clinical Centre, Somers Cancer Research Building, Experimental Pathology Group, Southampton General Hospital, Southampton and Biomedical Research Centre, School of Biological Sciences, University of East Anglia, Norwich, Norfolk, United Kingdom
    Clin Cancer Res 20:344-57. 2014
    ..This study investigated the functional and clinical significance of integrin αvβ6 upregulation in myoepithelial cells of ductal carcinoma in situ (DCIS)...
  26. pmc Comparing the expression of integrins αvβ3, αvβ5, αvβ6, αvβ8, fibronectin and fibrinogen in human brain metastases and their corresponding primary tumors
    Jens Schittenhelm
    Department of Neuropathology, Institute of Pathology and Neuropathology, University of Tübingen Tübingen 72076, Germany
    Int J Clin Exp Pathol 6:2719-32. 2013
    ..To evaluate the expression of αv-series integrins in brain metastases. Inhibitors targeting these integrins are being tested for their therapeutic potential...
  27. pmc ITGB6 loss-of-function mutations cause autosomal recessive amelogenesis imperfecta
    Shih Kai Wang
    Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1210 Eisenhower Place, Ann Arbor, MI 48108, USA
    Hum Mol Genet 23:2157-63. 2014
    ..Analysis of whole-exome sequences identified three integrin beta 6 (ITGB6) mutations responsible for their enamel malformations...
  28. pmc A missense mutation in ITGB6 causes pitted hypomineralized amelogenesis imperfecta
    James A Poulter
    Leeds Institutes of Molecular Medicine, University of Leeds, Leeds LS9 7TF, UK
    Hum Mol Genet 23:2189-97. 2014
    ..Whole-exome sequencing revealed a missense mutation (c.586C>A, p.P196T) in the I-domain of integrin-β6 (ITGB6), which is consistently predicted to be pathogenic by all available programmes and is the only variant that ..
  29. pmc αvβ6- and αvβ8-integrins serve as interchangeable receptors for HSV gH/gL to promote endocytosis and activation of membrane fusion
    Tatiana Gianni
    Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum University of Bologna, Bologna, Italy
    PLoS Pathog 9:e1003806. 2013
    ..We propose that placing the gH/gL activation under the integrin trigger point enables HSV to synchronize virion endocytosis with the cascade of glycoprotein activation that culminates in execution of fusion...
  30. doi E-Cadherin and EpCAM expression by NSCLC tumour cells associate with normal fibroblast activation through a pathway initiated by integrin αvβ6 and maintained through TGFβ signalling
    C Eberlein
    Oncology iMED, AstraZeneca, Alderley Park, Macclesfield, UK
    Oncogene 34:704-16. 2015
    ..In conclusion NSCLC cell lines, positive for E-Cadherin, EpCAM and αvβ6 expression, activate normal fibroblasts through avβ6/TGFβ signalling in vitro, and influence both gene expression and response to therapeutic agents. ..
  31. doi Development of a tetra-primer ARMS PCR-based assay for detection of a novel single-nucleotide polymorphism in the 5' untranslated region of the bovine ITGB6 receptor gene associated with foot-and-mouth disease susceptibility in cattle
    Rani Singh
    Molecular Genetic Laboratory, Animal Genetic and Breeding Division, Central Institute for Research on Cattle formerly Project Directorate on Cattle, Meerut Cantt, 250001, Uttar Pradesh, India
    Arch Virol 159:3385-9. 2014
    b>ITGB6 is known to be one of the major receptor components involved in host tropism of foot-and-mouth disease (FMD) virus in cattle...
  32. pmc Influenza promotes collagen deposition via αvβ6 integrin-mediated transforming growth factor β activation
    Lisa Jolly
    From the Nottingham Respiratory Research Unit, University of Nottingham, Nottingham University Hospitals, Clinical Sciences Building, City Hospital Campus, Nottingham NG5 1PB, United Kingdom
    J Biol Chem 289:35246-63. 2014
    ....
  33. pmc Fine mapping and candidate gene search of quantitative trait loci for growth and obesity using mouse intersubspecific subcongenic intercrosses and exome sequencing
    Akira Ishikawa
    Laboratory of Animal Genetics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Aichi, Japan
    PLoS ONE 9:e113233. 2014
    ..12 and that Ly75 and Itgb6 are putative candidate genes for Pbwg1.5...
  34. doi αvβ6 integrin may be a potential prognostic biomarker in interstitial lung disease
    Gauri Saini
    Division of Respiratory Medicine, University of Nottingham, Nottingham, UK
    Eur Respir J 46:486-94. 2015
    ..There was no association with the other markers measured.Our data suggest high levels of αvβ6 integrin may identify a specific endotype of progressive fibrotic lung disease. ..
  35. pmc Cloning and characterization of the human integrin β6 gene promoter
    Mingyan Xu
    Department of Oral Biology and Biomaterial, Xiamen Stomatological Research Institute, Xiamen Stomatological Hospital, Fujian, China Department of Basic Medical Science, Xiamen University Medical College, Xiamen, Fujian, China
    PLoS ONE 10:e0121439. 2015
    The integrin β6 (ITGB6) gene, which encodes the limiting subunit of the integrin αvβ6 heterodimer, plays an important role in wound healing and carcinogenesis...
  36. doi Integrin β6 can be translationally regulated by eukaryotic initiation factor 4E: Contributing to colonic tumor malignancy
    Liu Enyu
    Department of General Surgery, Qilu Hospital, Shandong University, Jinan, 250012, Shandong, People s Republic of China
    Tumour Biol 36:6541-50. 2015
    ..Thus, targeting eIF4E in integrin αvβ6 expressing tumors can be a potential therapeutic strategy for patients with colon cancer...
  37. pmc Polarized cell migration induces cancer type-specific CD133/integrin/Src/Akt/GSK3β/β-catenin signaling required for maintenance of cancer stem cell properties
    Ying Jhen Su
    Institute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu, Taiwan
    Oncotarget 6:38029-45. 2015
    ..lung cancer cell lines could be triggered by CD133, and β-catenin also bound to the proximal promoter regions of ITGB6 and ITGB8 in cell lines from gastric and breast cancers...
  38. pmc Expansion of the spectrum of ITGB6-related disorders to adolescent alopecia, dentogingival abnormalities and intellectual disability
    Muhammad Ansar
    Department of Biochemistry, Faculty of Biological Sciences, Quaid i Azam University, Islamabad, Pakistan
    Eur J Hum Genet 24:1223-7. 2016
    ..898G>A (p.(Glu300Lys)) in ITGB6, which co-segregates with the phenotype within the family and is predicted to be deleterious...
  39. pmc Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-β
    Javed Mohammed
    Department of Dermatology, Center for Immunology, University of Minnesota, Minneapolis, Minnesota USA
    Nat Immunol 17:414-21. 2016
    ..Our data demonstrated that regulated activation of TGF-β by stromal cells was able to directly control epithelial residence of cells of the immune system through a novel mechanism of intercellular communication. ..
  40. pmc Deciphering Transcriptome and Complex Alternative Splicing Transcripts in Mammary Gland Tissues from Cows Naturally Infected with Staphylococcus aureus Mastitis
    Xiu ge Wang
    Dairy Cattle Research Center, Shandong Academy of Agricultural Sciences, Jinan, Shandong, P R China
    PLoS ONE 11:e0159719. 2016
    ..Some immune-related genes, such as ITGB6, MYD88, ADA, ACKR1, and TNFRSF1B, and their potential relationships with mastitis were highlighted...
  41. pmc Amplification of TGFβ Induced ITGB6 Gene Transcription May Promote Pulmonary Fibrosis
    Amanda L Tatler
    Division of Respiratory Medicine City, University of Nottingham, Nottingham, United Kingdom
    PLoS ONE 11:e0158047. 2016
    ..We confirm that stimulation with exogenous TGFβ1 increases expression of the integrin β6 subunit gene (ITGB6) and αvβ6 integrin cell surface expression in a time- and concentration-dependent manner...
  42. pmc Co-expressed differentially expressed genes and long non-coding RNAs involved in the celecoxib treatment of gastric cancer: An RNA sequencing analysis
    Bin Song
    Department of Gastrointestinal Surgery, China Japan Union Hospital, Jilin University, Changchun, Jilin 130033, P R China
    Exp Ther Med 12:2455-2468. 2016
    ..i>ITGA3, ITGA6, ITGB4, ITGB5, ITGB6 and ITGB8 were enriched in the integrin-mediated signaling pathway...
  43. pmc Identification of functional pathways associated with the conditional ablation of serum response factor in Dstncorn1 mice
    Yanan Huo
    Eye Center, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P R China
    Mol Med Rep 15:139-145. 2017
    ..signaling pathway displayed the highest alteration score, and was enriched with integrin and integrin β‑6 (ITGB6)...
  44. doi RNA interference characterization of proteins discovered by proteomic analysis of pancreatic cancer reveals function in cell growth and survival
    Candy N Lee
    Department of Protein Therapeutic, Celera, Rockville, MD 20850, USA
    Pancreas 41:84-94. 2012
    ..We aimed to discover plasma membrane-associated proteins overexpressed in pancreatic cancer using quantitative proteomics and apply RNA interference (RNAi) to uncover proteins associated with cancer cell survival...
  45. pmc Early growth response factor-1 limits biliary fibrosis in a model of xenobiotic-induced cholestasis in mice
    Bradley P Sullivan
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Toxicol Sci 126:267-74. 2012
    ..this increase in liver fibrosis occurred in association with elevated expression of the β6 integrin (Itgb6) gene, suggesting the potential for increased local activation of transforming growth factor beta...
  46. doi A novel chondroectodermal dysplasia mapped to chromosome 2q24.1-q31.1
    Bushra Khan
    Department of Biochemistry, Faculty of Biological Sciences, Quaid i Azam University, Islamabad, Pakistan
    Eur J Med Genet 55:455-60. 2012
    ..37 was obtained with several markers along the disease interval. Sequence analysis of three candidate genes (TANK, ITGB6, TBR1) located in the candidate interval did not discover potentially causal variants.
  47. pmc TGF-β and αvβ6 integrin act in a common pathway to suppress pancreatic cancer progression
    Aram F Hezel
    Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer Res 72:4840-5. 2012
    ..Therefore, our findings indicate that αvβ6 and TGF-β act in a common tumor suppressor pathway whose pharmacologic inactivation promotes pancreatic cancer progression...
  48. pmc Effects of intrapulmonary viral tropism and cytokine expression on the histological patterns of cytomegalovirus pneumonia
    Yoshifumi Arai
    Department of Pathology, Hamamatsu University School of Medicine, Hamamtsu, Japan
    Pathol Int 62:628-39. 2012
    ..Expression of integrin β6 (ITGB6), an adhesion molecule and important activator of TGF-β1 in interstitial pneumonia, was lost in CMV-infected ..
  49. doi Critical role for αvβ6 integrin in enamel biomineralization
    Leila Mohazab
    Faculty of Dentistry, Department of Oral Biological and Medical Sciences, University of British Columbia, Vancouver, BC, Canada
    J Cell Sci 126:732-44. 2013
    ..Human and mouse ameloblasts were found to express both β6 integrin mRNA and protein. The maxillary incisors of Itgb6(-/-) mice lacked yellow pigment and their mandibular incisors appeared chalky and rounded...
  50. doi Kidney transplants with progressing chronic diseases express high levels of acute kidney injury transcripts
    K S Famulski
    Department of Laboratory Medicine and Pathology, Manchester, UK
    Am J Transplant 13:634-44. 2013
    ..Indeed, the injury signal shared many individual transcripts with the risk score, e.g. ITGB6, VCAN, NNMT...
  51. doi Longitudinal expression analysis of αv integrins in human gliomas reveals upregulation of integrin αvβ3 as a negative prognostic factor
    Jens Schittenhelm
    Department of Neuropathology, Institute of Pathology and Neuropathology, University of Tubingen, Tubingen, Germany
    J Neuropathol Exp Neurol 72:194-210. 2013
    ..cohort showed a similar increase in integrin expression with tumor grade, particularly of ITGB3 and ITGB8; ITGB6 was not expressed, consistent with the IHC data...
  52. doi Functional characterization of a porcine emphysema model
    Camilla Sichlau Bruun
    Department of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Grønnegårdsvej 3, 1870, Frederiksberg C, Denmark
    Lung 191:669-75. 2013
    ..MMP12-/- mice are protected from smoke-induced emphysema. ITGB6-/- mice spontaneously develop age-related lung emphysema due to lack of ITGB6-TGF-β1 regulation of the MMP12 ..
  53. doi Quantitative proteome analysis of alveolar type-II cells reveals a connection of integrin receptor subunits beta 2/6 and WNT signaling
    Regina T Mukhametshina
    LOEWE Research Group Lung Cancer Epigenetic, Division of Biomolecular Mass Spectrometry, Department of Lung Development and Remodeling, and Department of Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung Research, member of the Universities of Giessen and Marburg Lung Center UGMLC and German Center of Lung Research DZL, Parkstraße 1, 61231 Bad Nauheim, Germany
    J Proteome Res 12:5598-608. 2013
    ..Interestingly, we confirmed our data for two of these genes, integrin beta 2 and 6 (Itgb2 and Itgb6), by qRT-PCR expression analysis and Western blot analysis of protein extracts...
  54. ncbi The gene organization of the human beta 7 subunit, the common beta subunit of the leukocyte integrins HML-1 and LPAM-1
    W M Jiang
    Department of Molecular Medicine, School of Medicine, University of Auckland, New Zealand
    Int Immunol 4:1031-40. 1992
    ....
  55. ncbi Characterization of the integrin alpha v beta 6 as a fibronectin-binding protein
    M Busk
    Lung Biology Center, University of California, San Francisco 94143
    J Biol Chem 267:5790-6. 1992
    ..A., Smith, J. W., Cooper, H. M., and Quaranta, V. (1989) Cell 57, 59-69), is a mixture of at least two different receptors: alpha v beta 5, mediating adhesion to vitronectin, and alpha v beta 6, mediating adhesion to fibronectin...
  56. ncbi Chromosomal locations of the genes coding for the integrin beta 6 and beta 7 subunits
    G W Krissansen
    Department of Molecular Medicine, School of Medicine, University of Auckland, New Zealand
    Immunogenetics 35:58-61. 1992
  57. ncbi A point mutation in the integrin beta 6 subunit abolishes both alpha v beta 6 binding to fibronectin and receptor localization to focal contacts
    X Z Huang
    Lung Biology Center, UCSF 94143, USA
    Am J Respir Cell Mol Biol 13:245-51. 1995
    ....
  58. ncbi Regional localization of the human integrin beta 6 gene (ITGB6) to chromosome 2q24-q31
    E Fernandez-Ruiz
    Departamento de Inmunologia, Hospital de la Princesa, Universidad Autonoma de Madrid, Spain
    Genomics 21:638-40. 1994
    ..These data suggest a proximal position of the integrin beta 6 locus (ITGB6) on this integrin gene cluster...
  59. ncbi Effects of beta subunit cytoplasmic domain deletions on the recruitment of the integrin alpha v beta 6 to focal contacts
    R I Cone
    Lung Biology Center, University of California, San Francisco 94143 0854
    Cell Adhes Commun 2:101-13. 1994
    ..However, the unique 11 amino acid carboxy terminus of beta 6 is not required for this recruitment, and may actually play a negative regulatory role...
  60. ncbi Role of the integrin alpha v beta 6 in cell attachment to fibronectin. Heterologous expression of intact and secreted forms of the receptor
    A Weinacker
    Lung Biology Center, University of California, San Francisco 94143
    J Biol Chem 269:6940-8. 1994
    ..In such cells, fibronectin binding ability could be blocked by an antibody to alpha v integrins. These results constitute the first direct evidence that alpha v beta 6 mediates cell attachment to fibronectin...
  61. ncbi Differential effects of the integrins alpha9beta1, alphavbeta3, and alphavbeta6 on cell proliferative responses to tenascin. Roles of the beta subunit extracellular and cytoplasmic domains
    Y Yokosaki
    Lung Biology Center, Center for Occupational and Environmental Health, Cardiovascular Research Institute, Department of Medicine, University of California, San Francisco, San Francisco, California 94143, USA
    J Biol Chem 271:24144-50. 1996
    ....
  62. ncbi Expression of integrin cell adhesion receptors during human airway epithelial repair in vivo
    J M Pilewski
    Department of Medicine, University of Pittsburgh, Pennsylvania 15261, USA
    Am J Physiol 273:L256-63. 1997
    ....
  63. pmc Expression of alpha and beta subunits of the integrin superfamily in articular cartilage from macroscopically normal and osteoarthritic human femoral heads
    K Ostergaard
    Institute for Inflammation Research IIR, Rhima Centre, National University Hospital Rigshospitalet, Copenhagen, Denmark
    Ann Rheum Dis 57:303-8. 1998
    ..The objective of this study was to detail the topographical and zonal distribution of alpha and beta subunits of the integrin superfamily in normal and osteoarthritic cartilage...
  64. ncbi The role of integrins in reproduction
    J A Bowen
    Department of Anatomy and Cell Biology and Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160 7400, USA
    Proc Soc Exp Biol Med 223:331-43. 2000
    ....
  65. ncbi Mouse beta(6) integrin sequence, pattern of expression, and role in kidney development
    L J Arend
    Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA
    J Am Soc Nephrol 11:2297-305. 2000
    ..These findings suggest an important role for beta(6) integrin in normal development of the mouse kidney...
  66. ncbi alpha v beta 6 Integrin upregulates matrix metalloproteinase 9 and promotes migration of normal oral keratinocytes
    G J Thomas
    Department of Oral Pathology, Eastman Dental Institute, University College London, UK
    J Invest Dermatol 116:898-904. 2001
    ..It appears that alpha v beta 6 may function in normal human oral keratinocyte migration through matrix-metalloproteinase-9-dependent and -independent mechanisms...
  67. ncbi Increased expression of tenascin-C-binding epithelial integrins in human bullous keratopathy corneas
    A V Ljubimov
    Ophthalmology Research Laboratories, Burns and Allen Research Institute, Cedars Sinai Medical Center, University of California Los Angeles School of Medicine, Los Angeles, California 90048, USA
    J Histochem Cytochem 49:1341-50. 2001
    ..The interaction of tenascin-C with these integrins may contribute to the fibrotic process that occurs in PBK/ABK corneas...
  68. pmc Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin [beta] subunits
    Arjan van der Flier
    Netherlands Cancer Institute, Division of Cell Biology, 1066 CX Amsterdams, Netherlands
    J Cell Biol 156:361-76. 2002
    ..These findings suggest that specific combinations of filamin mRNA splicing events modulate the organization of the actin cytoskeleton and the binding affinity for integrins...
  69. ncbi Integrin expression in colon cancer cells is regulated by the cytoplasmic domain of the beta6 integrin subunit
    Jun Niu
    Newcastle Bowel Cancer Research Collaborative, Hunter Medical Research Institute, John Hunter Hospital, The University of Newcastle, Callaghan, New South Wales 2310, Australia
    Int J Cancer 99:529-37. 2002
    ..Given the dominance of the beta6-ERK2 interaction over PKC-mediated expression of both beta5 and beta6 integrin subunits, targeting the beta6-ERK2 interaction may prove useful as an anticancer strategy in colon cancer...
  70. pmc Integrin alpha(v)beta6-associated ERK2 mediates MMP-9 secretion in colon cancer cells
    X Gu
    Newcastle Bowel Cancer Research Collaborative, Hunter Medical Research Institute, John Hunter Hospital and The University of Newcastle, NSW 2308, Australia
    Br J Cancer 87:348-51. 2002
    ..Targetting either beta6 or its interaction with extracellular signal-regulated kinase in order to inhibit matrix metalloproteinase activity may offer a useful therapeutic approach in preventing growth and spread of colon cancer...
  71. ncbi Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema
    David G Morris
    Lung Biology Center, Department of Medicine, San Francisco General Hospital, San Francisco, California 94143, USA
    Nature 422:169-73. 2003
    ..Through a global analysis of pulmonary gene expression in the lungs of mice lacking this integrin (Itgb6 null mice) we have identified a marked induction of macrophage metalloelastase (Mmp12)--a metalloproteinase that ..
  72. pmc Integrin alpha v beta 6 is an RGD-dependent receptor for coxsackievirus A9
    Cigdem H Williams
    Department of Biological Sciences, University of Essex, Colchester CO4 3SQ, United Kingdom
    J Virol 78:6967-73. 2004
    ..Thus, integrin alpha(v)beta(6) is an RGD-dependent receptor for CAV9 and may be important in natural CAV9 infections...
  73. ncbi alpha(v)beta(6) Integrin expression in diseased and transplanted kidneys
    Paul Trevillian
    Newcastle Transplant Unit, John Hunter Hospital, Newcastle, New South Wales, Australia
    Kidney Int 66:1423-33. 2004
    ..Herein, we provide the first detailed description of an epithelial restricted integrin, alpha(v)beta(6), in kidney biopsies from patients suffering acute and chronic renal diseases and after transplantation...
  74. ncbi Hypoxia increases reepithelialization via an alphavbeta6-dependent pathway
    Paul F Ridgway
    Department of Surgical Oncology and Technology, Division of Surgery, Anesthetics and Intensive Care, Imperial College Faculty of Medicine, St Mary s Hospital, London, United Kingdom
    Wound Repair Regen 13:158-64. 2005
    ..05). Migration on fibronectin was attenuated by a specific gelatinase inhibitor. We conclude that integrin alphavbeta6-dependent MMP-2 and -9 up-regulation is an important feature of increased migration in hypoxic human keratinocytes...
  75. ncbi Distinct structural requirements for binding of the integrins alphavbeta6, alphavbeta3, alphavbeta5, alpha5beta1 and alpha9beta1 to osteopontin
    Yasuyuki Yokosaki
    Molecular Division, Department of Public Health, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minamiku, Hiroshima, 734 8551, Japan
    Matrix Biol 24:418-27. 2005
    ..These results suggest that the hierarchy of integrin interactions with osteopontin can undergo complex regulation at least in part through the action of extracellular proteases...
  76. ncbi Alpha v beta 6 integrin down-regulates the MMP-13 expression in oral squamous cell carcinoma cells
    M Ylipalosaari
    Department of Diagnostics and Oral Medicine, Institute of Dentistry, University of Oulu and Oulu University Hospital, PO Box 5281, FIN 90014 Oulu, Finland
    Exp Cell Res 309:273-83. 2005
    ..Our results suggest that alphavbeta6 down-regulates MMP-13 expression in OSCC cells and that MMP-13 is not essential for the degradation of type I collagen by OSCC cells...
  77. pmc Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury
    R Gisli Jenkins
    Lung Biology Center, UCSF, San Francisco, California 94158, USA
    J Clin Invest 116:1606-14. 2006
    ..ventilation is associated with increased pulmonary TGF-beta activation; however, this is not observed in Itgb6-/- mice. Furthermore, Itgb6-/- mice are also protected from ventilator-induced lung edema...
  78. ncbi Integrin alphavbeta6 mediates HT29-D4 cell adhesion to MMP-processed fibrinogen in the presence of Mn2+
    Francis Fouchier
    Laboratoire de Génie Génétique et Biotechnologie, INSERM 476, INRA 1260, Faculte de Pharmacie, 27 Bd Jean Moulin, F 13385 Marseille Cedex 5, France
    Eur J Cell Biol 86:143-60. 2007
    ..Finally, we found that Mn(2+) and activators of the ERK pathway cooperated in HT29-D4 cell adhesion to Fb. Such a process may be involved in bone metastasis of some cancer cells...
  79. pmc Constitutively activated Stat3 induces tumorigenesis and enhances cell motility of prostate epithelial cells through integrin beta 6
    Janeen Azare
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Mol Cell Biol 27:4444-53. 2007
    ..These results demonstrate the sufficiency of constitutively activated Stat3 in mediating prostate tumorigenesis and identify novel Stat3 targets that are involved in promoting cell migration and transformation...
  80. pmc Integrin beta6 mediates phospholipid and collectin homeostasis by activation of latent TGF-beta1
    Laura L Koth
    Lung Biology Center, Department of Medicine, San Francisco General Hospital, California, USA
    Am J Respir Cell Mol Biol 37:651-9. 2007
    ..Adult mice lacking the beta-subunit of alphavbeta6 (Itgb6-/-) developed increased bronchoalveolar lavage phospholipids and surfactant proteins A and D, and demonstrated ..
  81. pmc Systematic association mapping identifies NELL1 as a novel IBD disease gene
    Andre Franke
    Institute for Clinical Molecular Biology, Christian Albrechts University Kiel, Kiel, Germany
    PLoS ONE 2:e691. 2007
    ..Several associations were replicated in at least one independent sample, point to an involvement of ITGB6 (upstream), GRM8 (downstream), OR5V1 (downstream), PPP3R2 (downstream), NM_152575 (upstream) and HNF4G (intron).
  82. pmc Inhibition of integrin alpha(v)beta6, an activator of latent transforming growth factor-beta, prevents radiation-induced lung fibrosis
    Khalid Puthawala
    New York University School of Medicine, Department of Medicine, New York, NY 10282, USA
    Am J Respir Crit Care Med 177:82-90. 2008
    ..Because the integrin alpha(v)beta6 is a major TGF-beta activator in the lung, inhibition of alpha(v)beta6-mediated TGF-beta activation is a logical strategy to treat lung fibrosis...
  83. pmc Gene expression in human hippocampus from cocaine abusers identifies genes which regulate extracellular matrix remodeling
    Deborah C Mash
    Department of Neurology, Miller School of Medicine, University of Miami, Miami, Florida, United States of America
    PLoS ONE 2:e1187. 2007
    ..of the cytomatrix and synaptic connections and the inhibition of blood vessel proliferation (PCDH8, LAMB1, ITGB6, CTGF and EphB4)...
  84. doi Integrin alphavbeta6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapies
    Yury Popov
    Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Hepatol 48:453-64. 2008
    ..We studied alphavbeta6 expression in experimental and human liver fibrosis and the potential of its pharmacological inhibition for treatment of hepatic fibrosis...
  85. pmc Induction of an epithelial integrin alphavbeta6 in human cytomegalovirus-infected endothelial cells leads to activation of transforming growth factor-beta1 and increased collagen production
    Takako Tabata
    Department of Cell and Tissue Biology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0640, USA
    Am J Pathol 172:1127-40. 2008
    ..Our results suggest that activation of TGF-beta1 by integrin alphavbeta6 contributes to pathological changes and may impair endothelial cell functions in tissues that are chronically infected with CMV...
  86. pmc Phenotypic and genetic characterization of a novel phenotype in pigs characterized by juvenile hairlessness and age dependent emphysema
    Camilla S Bruun
    Department of Basic Animal and Veterinary Sciences, Faculty of Life Sciences, University of Copenhagen, Grønnegårdsvej 3, DK 1870 Frederiksberg, Denmark
    BMC Genomics 9:283. 2008
    ..Since the phenotype shows resemblance to the integrin beta6 -/- knockout phenotype seen in mice, the two genes encoding the two subunits of integrin alphavbeta6, i.e. ITGB6 and ITGAV, were considered candidate genes for this trait.
  87. doi Overexpression of the alphavbeta6 integrin in endometrial cancer
    Jonathan L Hecht
    Biogen Idec, Cambridge, MA, USA
    Appl Immunohistochem Mol Morphol 16:543-7. 2008
    ..Expression is high in metastatic lesions. The level of expression of the primary tumor was not indicative of the presence of nodal metastasis; however, the number of cases with nodal metastases was limited...
  88. doi Integrin alphaVbeta6 is a high-affinity receptor for coxsackievirus A9
    Outi Heikkilä
    Department of Virology, University of Turku, Kiinamyllynkatu 13, 20520 Turku, Finland
    J Gen Virol 90:197-204. 2009
    ..Similarly, only soluble alphaVbeta6 blocked virus infectivity. These data suggest that CAV9 binding to alphaVbeta6 is a high-affinity interaction, which may indicate its importance in clinical infections; this remains to be determined...
  89. pmc Mice that lack activity of alphavbeta6- and alphavbeta8-integrins reproduce the abnormalities of Tgfb1- and Tgfb3-null mice
    Poshala Aluwihare
    Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    J Cell Sci 122:227-32. 2009
    ..Most Itgb6-/-;Itgb8-/- embryos die at mid-gestation; those that survive develop cleft palate-as observed in Tgfb3-/- mice...
  90. doi Upregulation of Eps8 in oral squamous cell carcinoma promotes cell migration and invasion through integrin-dependent Rac1 activation
    L F Yap
    Department of Oral and Dental Science, University of Bristol, Bristol, UK
    Oncogene 28:2524-34. 2009
    ..These data suggest that Eps8 and Rac1 are part of an integrated signaling pathway modulating integrin-dependent tumour cell motility and identify Eps8 as a possible therapeutic target...
  91. pmc Targeted in vivo imaging of integrin alphavbeta6 with an improved radiotracer and its relevance in a pancreatic tumor model
    Sven H Hausner
    Department of Biomedical Engineering, University of California Davis, Davis, California 95616, USA
    Cancer Res 69:5843-50. 2009
    ..The fact that these tumors express alpha(v)beta(6) suggests that this probe has significant potential for the in vivo detection of this malignancy, thus having important implications for patient care and therapy...
  92. doi Vascular endothelial growth factor (VEGF) enhances gastric carcinoma invasiveness via integrin alpha(v)beta6
    Rui Zhao
    Department of Hepatobiliary Surgery, Qilu Hospital of Shandong University, Jinan 250012, Shandong, PR China
    Cancer Lett 287:150-6. 2010
    ..Taken together, the data suggest that VEGF is critical to the invasive process in human gastric cancer and that this occurs via up-regulation of integrin alphavbeta6 expression and activation of ERK...
  93. pmc Postural changes in blood pressure associated with interactions between candidate genes for chronic respiratory diseases and exposure to particulate matter
    Elissa Wilker
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 117:935-40. 2009
    ..Fine particulate matter [aerodynamic diameter </= 2.5 mum (PM(2.5))] has been associated with autonomic dysregulation...
  94. doi Confirmation of genomewide association signals in Chinese Han population reveals risk loci for ischemic stroke
    Hu Ding
    Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Stroke 41:177-80. 2010
    ..The first genomewide association study of ischemic stroke in whites has identified multiple susceptibility loci. We confirmed this study by examining associations with ischemic stroke in a Chinese Han population...
  95. doi Transforming growth factor beta (TGFB) signaling is activated during porcine implantation: proposed role for latency-associated peptide interactions with integrins at the conceptus-maternal interface
    Dana A Massuto
    Departments of Veterinary Integrative Biosciences Veterinary Large Animal Clinical Sciences Animal Science, Texas A and M University, College Station, Texas 77843 4458, USA
    Reproduction 139:465-78. 2010
    ..12, 16, 20, and 24 pregnant gilts were immunostained for TGFB, LAP, and ITG subunits (ITGAV, ITGB1, ITGB3, ITGB5, ITGB6, and ITGB8). Activation of TGFBRs was evaluated by the presence of phosphorylated downstream effector SMAD2/3...
  96. doi Severe pulmonary emphysema in a girl with interstitial deletion of 2q24.2q24.3 including ITGB6
    Shinichi Takatsuki
    The First Department of Pediatrics, Toho University Omori Medical Center, Tokyo, Japan
    Am J Med Genet A 152:1020-5. 2010
    ..The deletion region of 2q24.2 includes the integrin beta6 gene (ITGB6), which may prevent acute lung injury and pulmonary emphysema...
  97. pmc Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, and Brigham and Women s Hospital, Boston, MA, USA
    Hum Mol Genet 19:2706-15. 2010
    ..We identified significantly associated variants near RBMS1 and ITGB6 genes at 2q24, best-represented by SNP rs7593730 (combined OR=0.90, 95% CI=0.86-0.93; P=3.7x10(-8))...
  98. doi Two-dimensional heteronuclear saturation transfer difference NMR reveals detailed integrin αvβ6 protein-peptide interactions
    Jane L Wagstaff
    Protein Science Group, School of Biosciences, University of Kent, Canterbury, Kent, CT2 7NJ, UK
    Chem Commun (Camb) 46:7533-5. 2010
    ..This method, resulting in dramatically reduced overlap, was applied to the interaction of the integrin αvβ6 with a known peptide ligand and highlights novel contact points between the substrate and target protein...
  99. doi Gene expression in SK-Mel-28 human melanoma cells treated with the snake venom jararhagin
    Anelise Klein
    Genetics Laboratory, Butantan Institute, Av Vital Brazsil 1500, Sao Paulo, SP, CEP 05503 900, Brazil
    Toxicon 57:1-8. 2011
    ..30ng/μl upregulated genes TP53, CDKN1A, CDKN2A, CASP3, CASP5, CASP6, CASP8, and E-CDH in SK-Mel-28, and genes ITGB6, ITGB7, CASP3, TP53, and CDKN1B in fibroblasts...
  100. pmc Skin wound healing in diabetic β6 integrin-deficient mice
    Jasper N Jacobsen
    Laboratory of Periodontal Biology, Department of Oral Biological and Medical Sciences, University of British Columbia, Vancouver, BC, Canada
    APMIS 118:753-64. 2010
    ..These findings indicated that glycation of FN and possibly other integrin ligands could hamper keratinocyte interactions with the provisional matrix proteins during re-epithelialization of diabetic wounds...
  101. pmc The coagulation system contributes to alphaVbeta6 integrin expression and liver fibrosis induced by cholestasis
    Bradley P Sullivan
    Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Am J Pathol 177:2837-49. 2010
    ..These results indicate that a TF-PAR-1 pathway contributes to liver fibrosis induced by chronic cholestasis by increasing expression of the αVβ6 integrin, an important regulator of transforming growth factor-β1 activation...

Research Grants2

  1. INITIATION OF CELL INFECTION BY EPSTEIN-BARR VIRUS
    Lindsey Hutt Fletcher; Fiscal Year: 2004
    ..Dissection of the molecular events that enable EBV to access the cells it infects is critical to understanding the biology of this important human pathogen. ..
  2. Epstein-Barr virus glycoproteins and virus spread
    Lindsey Hutt Fletcher; Fiscal Year: 2009
    ..Effects of gM on recruitment of other glycoproteins will be examined. ..

Patents1

  1. A NOVEL INTEGRIN beta SUBUNIT AND USES THEREOF
    Patent Number: WO9212236-A1; Date:1992-07-23