ITCH

Summary

Gene Symbol: ITCH
Description: itchy E3 ubiquitin protein ligase
Alias: ADMFD, AIF4, AIP4, NAPP1, E3 ubiquitin-protein ligase Itchy homolog, HECT-type E3 ubiquitin transferase Itchy homolog, NFE2-associated polypeptide 1, atrophin-1 interacting protein 4, itchy E3 ubiquitin protein ligase homolog
Species: human

Top Publications

  1. ncbi Recognition of p63 by the E3 ligase ITCH: Effect of an ectodermal dysplasia mutant
    A Bellomaria
    Dipartimento di Scienze e Tecnologie Chimiche, University of Rome Tor Vergata, Italy
    Cell Cycle 9:3730-9. 2010
  2. pmc Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4
    Arun K Shukla
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 285:30115-25. 2010
  3. pmc The role of ITCH protein in human T-cell leukemia virus type 1 release
    Batsukh Dorjbal
    HIV Drug Resistance Program, NCI Frederick, Frederick, Maryland 21702, USA
    J Biol Chem 286:31092-104. 2011
  4. ncbi SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling
    Hong Liang Rui
    Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
    J Biol Chem 277:42981-6. 2002
  5. pmc Spartin activates atrophin-1-interacting protein 4 (AIP4) E3 ubiquitin ligase and promotes ubiquitination of adipophilin on lipid droplets
    Christopher Hooper
    Department of Molecular Pharmacology and Therapeutics, Loyola Chicago University, Maywood, IL, USA
    BMC Biol 8:72. 2010
  6. ncbi Atrophin-1-interacting protein 4/human Itch is a ubiquitin E3 ligase for human enhancer of filamentation 1 in transforming growth factor-beta signaling pathways
    Libing Feng
    Benaroya Research Institute at Virginia Mason, Seattle, Washington 98101, USA
    J Biol Chem 279:29681-90. 2004
  7. ncbi The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice
    W L Perry
    Mammalian Genetics Laboratory, ABL Basic Research Program, NCI Frederick Cancer Research and Development Center, Maryland 21702 1201, USA
    Nat Genet 18:143-6. 1998
  8. ncbi Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins
    J D Wood
    Division of Neurobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205 2196, USA
    Mol Cell Neurosci 11:149-60. 1998
  9. ncbi Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase
    L Qiu
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Biol Chem 275:35734-7. 2000
  10. pmc Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinases
    G Winberg
    Karolinska Institutet, Microbiology and Tumor Biology Center MTC, SE 171 77 Stockholm, Sweden
    Mol Cell Biol 20:8526-35. 2000

Research Grants

  1. Cytokine Signaling in Neurons: Inflammation, Pain and Pruritis
    Martin Steinhoff; Fiscal Year: 2013
  2. Genetic Mapping Of Novel Molecular Players in Itch
    RACHEL BETH BREM; Fiscal Year: 2013
  3. Mei Chuan Ko; Fiscal Year: 2014
  4. Behavioral Pharmacology of Itch
    Mei Chuan Ko; Fiscal Year: 2013
  5. Ethan A Lerner; Fiscal Year: 2014
  6. SARAH ELIZABETH ROSS; Fiscal Year: 2014
  7. Skin-Brain Mechanisms of Pruritus in Health and Disease
    Gil Yosipovitch; Fiscal Year: 2011
  8. Modulation of Pruritus by Spinal Cannabinoids
    Gregory W Terman; Fiscal Year: 2010
  9. ZHOUFENG CHEN; Fiscal Year: 2016
  10. Endocannabinoid Modulation of Pruritus
    JOEL SCHLOSBURG; Fiscal Year: 2009

Detail Information

Publications184 found, 100 shown here

  1. ncbi Recognition of p63 by the E3 ligase ITCH: Effect of an ectodermal dysplasia mutant
    A Bellomaria
    Dipartimento di Scienze e Tecnologie Chimiche, University of Rome Tor Vergata, Italy
    Cell Cycle 9:3730-9. 2010
    The E3 ubiquitin ligase Itch mediates the degradation of the p63 protein. Itch contains four WW domains which are pivotal for the substrate recognition process...
  2. pmc Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4
    Arun K Shukla
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 285:30115-25. 2010
    ..Arrestin 1 interacts with, and acts as an adaptor for AIP4, an E3 ubiquitin ligase responsible for TRPV4 ubiquitination...
  3. pmc The role of ITCH protein in human T-cell leukemia virus type 1 release
    Batsukh Dorjbal
    HIV Drug Resistance Program, NCI Frederick, Frederick, Maryland 21702, USA
    J Biol Chem 286:31092-104. 2011
    ..We tested nine members of the Nedd4 family ULs and found that ITCH is the main contributor to HTLV-1 budding...
  4. ncbi SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling
    Hong Liang Rui
    Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
    J Biol Chem 277:42981-6. 2002
    ..Taken together, we demonstrate that sumoylation plays a role for Axin to function in the JNK pathway...
  5. pmc Spartin activates atrophin-1-interacting protein 4 (AIP4) E3 ubiquitin ligase and promotes ubiquitination of adipophilin on lipid droplets
    Christopher Hooper
    Department of Molecular Pharmacology and Therapeutics, Loyola Chicago University, Maywood, IL, USA
    BMC Biol 8:72. 2010
    ..belong to the neural precursor cell-expressed developmentally downregulated gene (Nedd4) family, including atrophin-1-interacting protein 4 (AIP4/ITCH). However, the biological importance of the spartin-AIP4 interaction remains unknown.
  6. ncbi Atrophin-1-interacting protein 4/human Itch is a ubiquitin E3 ligase for human enhancer of filamentation 1 in transforming growth factor-beta signaling pathways
    Libing Feng
    Benaroya Research Institute at Virginia Mason, Seattle, Washington 98101, USA
    J Biol Chem 279:29681-90. 2004
    Atrophin-1-interacting protein 4 (AIP4) is the human homolog of the mouse Itch protein (hItch), an E3 ligase for Notch and JunB...
  7. ncbi The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice
    W L Perry
    Mammalian Genetics Laboratory, ABL Basic Research Program, NCI Frederick Cancer Research and Development Center, Maryland 21702 1201, USA
    Nat Genet 18:143-6. 1998
    ..affects two loci: agouti and another, as yet unidentified locus designated itchy (the provisional gene symbol is Itch), that is responsible for the immunological phenotype of a18H mice...
  8. ncbi Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins
    J D Wood
    Division of Neurobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205 2196, USA
    Mol Cell Neurosci 11:149-60. 1998
    ..AIP2/WWP2, AIP4, and AIP5/WWP1 are highly homologous, each having four WW domains and a HECT domain characteristic of ubiquitin ..
  9. ncbi Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase
    L Qiu
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Biol Chem 275:35734-7. 2000
    Genetic studies identified Itch, which is a homologous to the E6-associated protein carboxyl terminus (Hect) domain-containing E3 ubiquitin-protein ligase that is disrupted in non-agouti lethal mice or Itchy mice...
  10. pmc Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinases
    G Winberg
    Karolinska Institutet, Microbiology and Tumor Biology Center MTC, SE 171 77 Stockholm, Sweden
    Mol Cell Biol 20:8526-35. 2000
    ..the PPPPY motifs of LMP2A bind multiple WW domains of E3 protein-ubiquitin ligases of the Nedd4 family, including AIP4 and KIAA0439, and demonstrate that AIP4 and KIAA0439 form physiological complexes with LMP2A in EBV-positive B ..
  11. ncbi beta 1-adrenergic receptor association with the synaptic scaffolding protein membrane-associated guanylate kinase inverted-2 (MAGI-2). Differential regulation of receptor internalization by MAGI-2 and PSD-95
    J Xu
    Department of Pharmacology, Rollins Research Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 276:41310-7. 2001
    ....
  12. ncbi N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein
    Kieran F Harvey
    Hanson Center for Cancer Research, Institute of Medical and Veterinary Science, Frome Road, Adelaide, South Australia 5000, Australia
    J Biol Chem 277:9307-17. 2002
    ..Based on previous observations in yeast, we propose that N4WBP5 may act as an adaptor for Nedd4-like proteins and their putative targets to control ubiquitin-dependent protein sorting and trafficking...
  13. ncbi Interaction between two ubiquitin-protein isopeptide ligases of different classes, CBLC and AIP4/ITCH
    Jean Remy Courbard
    Département d Oncologie Moléculaire, U119 INSERM, 27 Boulevard Lei Roure, 13009 Marseille and Ipsogen SA, Institut Paoli Calmettes, 3009 Marseille, France
    J Biol Chem 277:45267-75. 2002
    ..elegans library using the two-hybrid procedure in yeast, we found a novel interaction between Hsa-CBLC and Hsa-AIP4 or its C. elegans counterpart Cel-WWP1. Hsa-AIP4 and Cel-WWP1 are also ubiquitin E3 ligases...
  14. ncbi Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain
    Melanie A McGill
    Department of Medical Biophysics, University of Toronto and The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    J Biol Chem 278:23196-203. 2003
    ..In agreement we demonstrate that Numb interacts with the cytosolic HECT domain-containing E3 ligase Itch and that Numb and Itch act cooperatively to promote ubiquitination of membrane-tethered Notch1...
  15. ncbi The RING-H2 protein RNF11 is differentially expressed in breast tumours and interacts with HECT-type E3 ligases
    Richard Kitching
    Molecular and Cellular Biology Research, Sunnybrook and Women s College Health Sciences Centre, Toronto, Canada
    Biochim Biophys Acta 1639:104-12. 2003
    ..Our GST-pulldown and immunoprecipitation results indicate that RNF11 interacts with the E3 ligase AIP4 when coexpressed with RNF11 in mammalian cells.
  16. ncbi The HECT domain ligase itch ubiquitinates endophilin and localizes to the trans-Golgi network and endosomal system
    Annie Angers
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University St, Montreal, Quebec H3A 2B4, Canada
    J Biol Chem 279:11471-9. 2004
    ..We have identified the E3 ubiquitin ligase itch/AIP4 as an endophilin A1-binding partner...
  17. ncbi N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking
    Linda M Shearwin-Whyatt
    Hanson Institute, IMVS, Frome Road, Adelaide, SA 5000, Australia
    J Cell Sci 117:3679-89. 2004
    ..We propose that N4WBP5A acts as an adaptor to recruit Nedd4 family ubiquitin-protein ligases to the protein trafficking machinery...
  18. ncbi Itch E3 ligase-mediated regulation of TGF-beta signaling by modulating smad2 phosphorylation
    Yongli Bai
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Mol Cell 15:825-31. 2004
    ..Here we show that loss of Itch E3 ligase in mouse embryonic fibroblasts (MEFs) results in reduced susceptibility of TGF-beta-induced cell growth ..
  19. pmc Ubiquitin-mediated fluorescence complementation reveals that Jun ubiquitinated by Itch/AIP4 is localized to lysosomes
    Deyu Fang
    Howard Hughes Medical Institute, Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109 0650, USA
    Proc Natl Acad Sci U S A 101:14782-7. 2004
    ..Mutation of a recognition sequence for the E3 ligase Itch/AIP4 prevented Jun ubiquitination and stabilized it in cells...
  20. pmc The ubiquitin-protein ligase Itch regulates p73 stability
    Mario Rossi
    Department of Biology, University of Rome Tor Vergata, Rome, Italy
    EMBO J 24:836-48. 2005
    ..However, unlike p53, p73 binds to, but is not degraded by, MDM2. Here we describe the binding of p73 to Itch, a Hect ubiquitin-protein ligase...
  21. ncbi AIP4 restricts transforming growth factor-beta signaling through a ubiquitination-independent mechanism
    Francois Lallemand
    INSERM U482, Hopital Saint Antoine, 184 rue du Faubourg Saint Antoine, 75571 Paris Cedex 12, France
    J Biol Chem 280:27645-53. 2005
    ..Using the two-hybrid screen, we identified atrophin 1-interacting protein 4 (AIP4) as an E3 ubiquitin ligase that specifically targets Smad7 for ubiquitin-dependent degradation without affecting ..
  22. ncbi Negative regulation of the E3 ubiquitin ligase itch via Fyn-mediated tyrosine phosphorylation
    Chun Yang
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92130, USA
    Mol Cell 21:135-41. 2006
    ..mechanism involves regulation of the E3 Ub ligase, for example, the JNK-dependent phosphorylation and activation of Itch E3 ligase, which controls the turnover of Jun proteins and T cell differentiation...
  23. pmc Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change
    Ewen Gallagher
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0723, USA
    Proc Natl Acad Sci U S A 103:1717-22. 2006
    The E3 ubiquitin (Ub) ligase Itch is a critical regulator of T helper 2 (Th2) cytokine production through its ability to induce Ub-dependent JunB degradation...
  24. pmc CISK attenuates degradation of the chemokine receptor CXCR4 via the ubiquitin ligase AIP4
    Thomas Slagsvold
    Department of Biochemistry, the Norwegian Radium Hospital and the University of Oslo, Montebello, Oslo, Norway
    EMBO J 25:3738-49. 2006
    ..CISK strongly interacts and colocalizes with the E3 ubiquitin ligase AIP4, which is important for the ubiquitin-dependent lysosomal degradation of CXCR4...
  25. ncbi The tyrosine kinase c-Abl protects c-Jun from ubiquitination-mediated degradation in T cells
    Beixue Gao
    Department of Otolaryngology Head and Neck Surgery, University of Missouri Columbia School of Medicine, Columbia, Missouri 65212, USA
    J Biol Chem 281:29711-8. 2006
    ..We have previously demonstrated that c-Jun is a substrate of Itch, a HECT-type E3 ubiquitin ligase. c-Jun is also a substrate of the tyrosine kinase c-Abl...
  26. pmc The E3 ubiquitin ligase Itch controls the protein stability of p63
    Mario Rossi
    Medical Research Council, Toxicology Unit, Leicester University, Leicester LE1 9HN, United Kingdom
    Proc Natl Acad Sci U S A 103:12753-8. 2006
    ..that the Hect (homologous to the E6-associated protein C terminus)-containing Nedd4-like ubiquitin protein ligase Itch binds, ubiquitylates, and promotes the degradation of p63...
  27. ncbi Molecular mechanisms of coupled monoubiquitination
    Tanja Woelk
    IFOM, The FIRC Institute for Molecular Oncology, Via Adamello 16, 20139, Milan, Italy
    Nat Cell Biol 8:1246-54. 2006
    ..Thus, our results clarify the mechanism of coupled monoubiquitination and identify the ubiquitination of E3 ligases as a critical determinant in this process...
  28. pmc Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains
    Patricia Chastagner
    Unite de Signalisation Moleculaire et Activation Cellulaire, URA 2582, CNRS, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    EMBO Rep 7:1147-53. 2006
    Deltex (DTX) and AIP4 are the human orthologues of the Drosophila deltex and Suppressor of deltex, which have been genetically described as being antagonistically involved in the Notch signalling pathway...
  29. ncbi The ubiquitin ligase itch is auto-ubiquitylated in vivo and in vitro but is protected from degradation by interacting with the deubiquitylating enzyme FAM/USP9X
    Rania Mouchantaf
    Départment de Sciences Biologiques, Universite de Montreal, Station Centre Ville, Montreal, Quebec H3C 3J7, Canada
    J Biol Chem 281:38738-47. 2006
    b>Itch is a ubiquitin ligase that has been implicated in the regulation of a number of cellular processes...
  30. pmc The HECT ubiquitin ligase AIP4 regulates the cell surface expression of select TRP channels
    Tomasz Wegierski
    Renal Division, University Hospital Freiburg, Hugstetter Strasse 55, Freiburg 79106, Germany
    EMBO J 25:5659-69. 2006
    ..of TRPV4 is dramatically increased by the HECT (homologous to E6-AP carboxyl terminus)-family ubiquitin ligase AIP4 without inducing degradation of this channel...
  31. ncbi Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination
    Lucia Di Marcotullio
    Department of Experimental Medicine and Pathology, University La Sapienza, Roma, 324 Viale Regina Elena, 00161 Roma, Italy
    Nat Cell Biol 8:1415-23. 2006
    ..We demonstrate that the Hedgehog transcription factor Gli1 is targeted by Numb for Itch-dependent ubiquitination, which suppresses Hedgehog signals, thus arresting growth and promoting cell ..
  32. doi The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20
    Noula Shembade
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, The University of Miami, Miller School of Medicine, Miami, Florida 33136, USA
    Nat Immunol 9:254-62. 2008
    ..Here we demonstrate that the regulatory molecule TAX1BP1 recruited the E3 ligase Itch to A20 via two 'PPXY' motifs...
  33. pmc The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1
    K Venuprasad
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA
    Nat Immunol 9:245-53. 2008
    ..However, the molecular mechanisms leading to Foxp3 induction remain unclear. Here we show that Itch-/- T cells were resistant to TGF-beta treatment and had less Foxp3 expression...
  34. pmc Isoform-specific monoubiquitination, endocytosis, and degradation of alternatively spliced ErbB4 isoforms
    Maria Sundvall
    MediCity Research Laboratory and Department of Medical Biochemistry and Molecular Biology, University of Turku, FIN 20520 Turku, Finland
    Proc Natl Acad Sci U S A 105:4162-7. 2008
    ..and endocytosis of CYT-1 isoforms and provided a binding site for a WW domain-containing ubiquitin ligase Itch. Itch catalyzed ubiquitination of ErbB4 CYT-1, promoted its localization into intracellular vesicles, and ..
  35. pmc Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor
    Sudha K Shenoy
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 283:22166-76. 2008
    ..ubiquitination and lysosomal degradation, whereas siRNA targeting the closely related E3 ligases Nedd4-2 or AIP4 did not...
  36. doi A regulatory circuit controlling Itch-mediated p73 degradation by Runx
    Dan Levy
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100 Israel
    J Biol Chem 283:27462-8. 2008
    ..The level of p73 is regulated by the E3 ligase Itch. Itch levels are sharply reduced in response to DNA damage with concomitant p73 accumulation and activation...
  37. doi Itch self-polyubiquitylation occurs through lysine-63 linkages
    Flavia Scialpi
    IDI IRCCS Biochemistry Laboratory, Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Biochem Pharmacol 76:1515-21. 2008
    b>Itch, an E3 protein ubiquitin ligase (E3), which belongs to the homologous to E6-AP carboxy terminus (HECT)-type subfamily, catalyzes its own ubiquitylation...
  38. doi ITCH is a putative target for a novel 20q11.22 amplification detected in anaplastic thyroid carcinoma cells by array-based comparative genomic hybridization
    Takaya Ishihara
    Department of Molecular Cytogenetics, Medical Research Institute and School of Biomedical Science, Tokyo, Japan
    Cancer Sci 99:1940-9. 2008
    ..aberrations using array-based comparative genomic hybridization, we identified a high-level amplification of the ITCH gene, which is mapped to 20q11...
  39. pmc The E3 ubiquitin ligase atrophin interacting protein 4 binds directly to the chemokine receptor CXCR4 via a novel WW domain-mediated interaction
    Deepali Bhandari
    Program in Molecular Biology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA
    Mol Biol Cell 20:1324-39. 2009
    The E3 ubiquitin ligase atrophin interacting protein 4 (AIP4) mediates ubiquitination and down-regulation of the chemokine receptor CXCR4...
  40. pmc The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling
    Noula Shembade
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, Miller School of Medicine, The University of Miami, Miami, FL 33136, USA
    EMBO J 28:513-22. 2009
    ..Our studies reveal that RNF11, together with TAX1BP1 and Itch, is an essential component of an A20 ubiquitin-editing protein complex that ensures transient activation of ..
  41. pmc A role for ubiquitin ligases and Spartin/SPG20 in lipid droplet turnover
    Scott W Eastman
    Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA
    J Cell Biol 184:881-94. 2009
    ..These experiments suggest functions for ubiquitin ligases and SPG20 in the regulation of LD turnover and potential pathological mechanisms in Troyer syndrome...
  42. doi Reciprocal regulation of the ubiquitin ligase Itch and the epidermal growth factor receptor signaling
    Bilal A Azakir
    Departement de sciences biologiques, Universite de Montreal, Montreal, QC H3C3J7, Canada
    Cell Signal 21:1326-36. 2009
    ..we demonstrate that treatment of cells with EGF leads to JNK-dependent phosphorylation of the ubiquitin ligase Itch, stimulating Itch ligase activity...
  43. pmc Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins
    Thomas Mund
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    EMBO Rep 10:501-7. 2009
    ..membrane proteins, NDFIP1 and NDFIP2 (NEDD4 family-interacting proteins), activate the catalytic activity of ITCH and of several other HECT ligases by binding to them...
  44. pmc Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5
    Thomas L Edwards
    University of Liverpool, UK
    Biochem J 423:31-9. 2009
    ..demonstrate that it interacts via a PPXY motif with the ubiquitin E3 ligases AIP4 [atrophin-interacting protein 4; ITCH (itchy E3 ubiquitin protein ligase homologue] [corrected] and AIP5 (WWP1)...
  45. doi Identification of novel spartin-interactors shows spartin is a multifunctional protein
    Malgorzata Milewska
    School of Medicine and Medical Science, Conway Institute, University College Dublin, Ireland
    J Neurochem 111:1022-30. 2009
    ..published information about spartin interaction with ubiquitin and the E3 ubiquitin-protein ligases, AIP4/Itch and AIP5/WWP1...
  46. pmc A novel PTEN-dependent link to ubiquitination controls FLIPS stability and TRAIL sensitivity in glioblastoma multiforme
    Amith Panner
    Brain Tumor Research Center, Department of Neurological Surgery and University of California San Francisco Comprehensive Cancer Center, University of California San Francisco, San Francisco, California 94158 9001, USA
    Cancer Res 69:7911-6. 2009
    ..Total levels of the candidate FLIP(S) E3 ubiquitin ligase atrophin-interacting protein 4 (AIP4) were comparable in PTEN wild-type (WT) and PTEN mutant GBM cells, although in PTEN-deficient cells, AIP4 was ..
  47. pmc The ubiquitin ligase itch regulates apoptosis by targeting thioredoxin-interacting protein for ubiquitin-dependent degradation
    Pingzhao Zhang
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, China
    J Biol Chem 285:8869-79. 2010
    ..Here, we report that TXNIP undergoes proteasomal degradation in cells. We identify Itch as the E3 ubiquitin ligase for TXNIP...
  48. pmc Human ITCH E3 ubiquitin ligase deficiency causes syndromic multisystem autoimmune disease
    Naomi J Lohr
    Clinical Genetics and Metabolism, Department of Pediatrics, University of Colorado at Denver, Aurora, CO, USA
    Am J Hum Genet 86:447-53. 2010
    Ubiquitin ligases play an important role in the regulation of the immune system. Absence of Itch E3 ubiquitin ligase in mice has been shown to cause severe autoimmune disease...
  49. doi The ubiquitin ligase Itch mediates the antiapoptotic activity of epidermal growth factor by promoting the ubiquitylation and degradation of the truncated C-terminal portion of Bid
    Bilal A Azakir
    Departement de sciences biologiques, Universite de Montreal, Montreal, Quebec, Canada
    FEBS J 277:1319-30. 2010
    ..Here, we provide evidence that tBid is a substrate of the ubiquitin ligase Itch, which can specifically interact with and ubiquitinate tBid, but not intact Bid...
  50. pmc Cbl-b and itch: key regulators of peripheral T-cell tolerance
    K Venuprasad
    Department of Immunology and Microbiology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Cancer Res 70:3009-12. 2010
    E3 ligases Cbl-b and Itch have emerged as dominant "tolerogenic" regulators of T cells because their deficiency results in severe autoimmune diseases...
  51. doi Multiple modification and protein interaction signals drive the Ring finger protein 11 (RNF11) E3 ligase to the endosomal compartment
    E Santonico
    Department of Molecular Biology, Tor Vergata University of Rome, Rome, Italy
    Oncogene 29:5604-18. 2010
    ..moieties and that loss of acylation severely impairs the in vivo ubiquitination mediated by the HECT E3-ligases Itch and Nedd4...
  52. doi Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal
    L Di Marcotullio
    Department of Molecular Medicine, Sapienza University, Rome, Italy
    Oncogene 30:65-76. 2011
    ..of an ubiquitin-mediated mechanism of Gli1 degradation, promoted by the coordinated action of the E3 ligase Itch and the adaptor protein Numb...
  53. pmc Multiple interactions between the ESCRT machinery and arrestin-related proteins: implications for PPXY-dependent budding
    Susanne Rauch
    Department of Infectious Diseases, King s College London School of Medicine, London, United Kingdom
    J Virol 85:3546-56. 2011
    ..virus type 1 (HTLV-1) access the ESCRT pathway via interaction with HECT ubiquitin ligases (WWP1, WWP2, and Itch). However, the mechanism of ESCRT-III recruitment in this context remains elusive...
  54. doi Negative regulation of the Hippo pathway by E3 ubiquitin ligase ITCH is sufficient to promote tumorigenicity
    Zaidoun Salah
    The Lautenberg Center for Immunology and Cancer Research, IMRIC, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Cancer Res 71:2010-20. 2011
    ..In this study, we report that the E3 ubiquitin ligase ITCH regulates stability of LATS1, a serine/threonine kinase in the Hippo pathway, through protein-protein interaction ..
  55. pmc Itch E3 ubiquitin ligase regulates large tumor suppressor 1 stability [corrected]
    King Ching Ho
    Department of Pathology and Molecular Medicine, Queen s University, Kingston, ON, Canada K7L 3N6
    Proc Natl Acad Sci U S A 108:4870-5. 2011
    ..In this study, we have identified Itch, a HECT class E3 ubiquitin ligase, as a unique binding partner of LATS1...
  56. pmc Novel roles for the E3 ubiquitin ligase atrophin-interacting protein 4 and signal transduction adaptor molecule 1 in G protein-coupled receptor signaling
    Rohit Malik
    Program in Molecular Biology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 60153, USA
    J Biol Chem 287:9013-27. 2012
    ..Ubiquitin modification of CXCR4 by the E3 ubiquitin ligase AIP4 is required for lysosomal sorting and degradation, which is mediated by the endosomal sorting complex required for ..
  57. doi The Nedd4-like ubiquitin E3 ligases target angiomotin/p130 to ubiquitin-dependent degradation
    Chenji Wang
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, PR China
    Biochem J 444:279-89. 2012
    ..neural-precursor-cell-expressed developmentally down-regulated)-like ubiquitin E3 ligases, Nedd4, Nedd4-2 and Itch, as the ubiquitin E3 ligases for the long isoform of AMOT, AMOT/p130...
  58. pmc The E3 ubiquitin ligase ITCH negatively regulates canonical Wnt signaling by targeting dishevelled protein
    Wei Wei
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Mol Cell Biol 32:3903-12. 2012
    ..Here, we identify the HECT-containing Nedd4-like ubiquitin E3 ligase ITCH as a new Dvl-binding protein...
  59. pmc HIV-1 Nef impairs heterotrimeric G-protein signaling by targeting Gα(i2) for degradation through ubiquitination
    Prabha Chandrasekaran
    Laboratory of Molecular Immunology, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 287:41481-98. 2012
    ..Here, we report that a dominant effect of Nef is to trigger AIP4 E3 ligase-mediated Gα(i2) ubiquitination, which leads to Gα(i2) endolysosomal sequestration and destruction...
  60. pmc Amot130 adapts atrophin-1 interacting protein 4 to inhibit yes-associated protein signaling and cell growth
    Jacob J Adler
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 288:15181-93. 2013
    ..This study describes how Amot130 through binding and activating the ubiquitin ligase AIP4/Itch achieves these effects. AIP4 is found to bind and ubiquitinate Amot130 at residue Lys-481...
  61. pmc NEDD4 E3 ligase inhibits the activity of the Hippo pathway by targeting LATS1 for degradation
    Zaidoun Salah
    The Lautenberg Center for Immunology and Cancer Research IMRIC Hebrew University Hadassah Medical School Jerusalem, Israel Al Quds Bard Honors College Al Quds University East Jerusalem Abu Dies, Palestine
    Cell Cycle 12:3817-23. 2013
    ..These findings might be applied in the development of new therapeutic approaches through the activation of LATS1. ..
  62. ncbi The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4
    Adriano Marchese
    Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Dev Cell 5:709-22. 2003
    ..Here we report that the Nedd4-like E3 ubiquitin ligase AIP4 mediates ubiquitination of CXCR4 at the plasma membrane, and of the ubiquitin binding protein Hrs on endosomes...
  63. ncbi The Vif protein of human immunodeficiency virus type 1 is posttranslationally modified by ubiquitin
    Sylvie Dussart
    INSERM Unit 372, Universite de la Mediterranee, 163 Avenue de Luminy, BP178, 13276 Marseille Cedex 09, France
    Biochem Biophys Res Commun 315:66-72. 2004
    ..Here, we show that Vif binds to hNedd4 and AIP4, two HECT E3 ubiquitin ligases. WW domains present in those HECT enzymes contribute to the binding of Vif...
  64. ncbi The Yes-associated protein 1 stabilizes p73 by preventing Itch-mediated ubiquitination of p73
    D Levy
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Cell Death Differ 14:743-51. 2007
    ..The ubiquitin E3 ligase Itch, like Yap1, interacts with p73...
  65. pmc The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch
    Andrew Oberst
    Biochemistry Laboratory, Istituto Dermopatico dell Immacolata Istituto di Ricovero e Cura a Carattere Scientifico, University of Rome Tor Vergata, 00133 Rome, Italy
    Proc Natl Acad Sci U S A 104:11280-5. 2007
    ..Here, we describe a previously unrecognized functional interaction between N4BP1 and Itch, a Nedd4 structurally related E3, which contains four WW domains, conferring substrate-binding activity...
  66. ncbi Arrestin-2 interacts with the ubiquitin-protein isopeptide ligase atrophin-interacting protein 4 and mediates endosomal sorting of the chemokine receptor CXCR4
    Deepali Bhandari
    Department of Pharmacology and Experimental Therapeutics, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA
    J Biol Chem 282:36971-9. 2007
    ..CXCR4 is rapidly targeted for lysosomal degradation by the E3 ubiquitin ligase atrophin-interacting protein 4 (AIP4)...
  67. pmc The effect of cyclic AMP elevating agents on bradykinin- and carbachol-induced signal transduction in canine cultured tracheal smooth muscle cells
    C M Yang
    Department of Pharmacology, Chang Gung Medical College, Kwei San, Tao Yuan, Taiwan
    Br J Pharmacol 112:781-8. 1994
    ..b>AIF4-induced IPs accumulation was not affected by CTX, forskolin, or dibutyryl cyclic AMP treatment, supporting the ..
  68. ncbi [Clinical manifestation and patho-typing of biliary cast syndrome in patients after orthotopic liver transplantation]
    Xiao Dan Zhu
    Institute of Liver Transplantation, General Hospital of Chinese Armed Police Forces, Beijing 100039, China
    Zhonghua Wai Ke Za Zhi 46:728-32. 2008
    ..To summarize the Patho-typing and the clinical manifestation of biliary cast syndrome (BCS) in patients after orthotopic liver transplantation...
  69. ncbi Disorders of keratinization: diagnosis and management
    Tor Shwayder
    Pediatric Dermatology, Henry Ford Hospital, Detroit, Michigan 48202 2689, USA
    Am J Clin Dermatol 5:17-29. 2004
    ..Treatment is with aggressive moisturization. Hydrocortisone creams may be needed to control itch. Recessive X-linked ichthyosis is due to a deficiency of cholesterol sulfatase...
  70. ncbi The efficacy of Prrrikweg gel in the treatment of insect bites: a double-blind, placebo-controlled clinical trial
    N Hill
    London School of Hygiene and Tropical Medicine, London, UK
    Pharm World Sci 18:35-41. 1996
    ..5, 1, 26.5, and 48 h post-bite to compare the itch-relieving efficacy of the two treatments...
  71. ncbi Itch and atopic dermatitis: clinical and experimental studies
    C F Wahlgren
    Department of Dermatology, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden
    Acta Derm Venereol Suppl (Stockh) 165:1-53. 1991
    The aims of the study were to develop and evaluate methods for quantitative measurement of itch, to investigate the perception of itch in patients with atopic dermatitis (AD), and to measure itch in such patients during treatment with H1-..
  72. pmc Primary sclerosing cholangitis, autoimmune hepatitis and overlap syndromes in inflammatory bowel disease
    Rebecca Saich
    The Department of Gastroenterology, The John Radcliffe Hospital, Headley Way, Headington, Oxford, Oxfordshire, United Kingdom
    World J Gastroenterol 14:331-7. 2008
    ..Symptoms include itch and lethargy and in advanced cases cholangitis and end-stage liver disease, however increasing numbers of ..
  73. ncbi Endometrial responsiveness to oxytocin during diestrus and early pregnancy in pigs is not controlled solely by changes in oxytocin receptor population density
    T E Ludwig
    Department of Animal Sciences, Washington State University, Pullman 99164 6353, USA
    Biol Reprod 58:769-77. 1998
    ..05), and during pregnancy only on Day 12 (p < 0.05). Activation of G protein by aluminum fluoride (AIF4-) treatment maximally stimulated (p < 0...
  74. doi Expression of toll-like receptor 2, NOD2 and dectin-1 and stimulatory effects of their ligands and histamine in normal human keratinocytes
    M Kobayashi
    Department of Dermatology, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Br J Dermatol 160:297-304. 2009
    ..Histamine, which is well known for itch and allergy, is closely associated with innate immunity, but its influence on epidermal innate immunity is still ..
  75. pmc Late domain-independent rescue of a release-deficient Moloney murine leukemia virus by the ubiquitin ligase itch
    Joshua A Jadwin
    Laboratory of Molecular Microbiology, NIAID, NIH, 4 Center Dr, Bethesda, MD 20892, USA
    J Virol 84:704-15. 2010
    ..However, low-level expression of the ubiquitin ligase Itch potently rescued the release and infectivity of MoMLV lacking PPPY function...
  76. ncbi Relationship between specific binding of 125I-omega-conotoxin GVIA and GTP binding protein: effects of the GTP analogues, mastoparan and A1F4-
    S Ichida
    Department of Biological Chemistry, Faculty of Pharmaceutical Sciences, Kinki University, Higashi Osaka, Japan
    Biochim Biophys Acta 1325:215-25. 1997
    ..endogenous GTP binding protein (G protein) was activated by GTP analogues, mastoparan (MP) and aluminum fluoride (AIF4-; AICl3 + NaF)...
  77. ncbi Progressive macular hypomelanosis: an overview
    Germaine N Relyveld
    The Netherlands Institute for Pigment Disorders, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Am J Clin Dermatol 8:13-9. 2007
    ..There is no itch, pain, or preceding inflammation...
  78. ncbi Dietary intake of the flower extracts of German chamomile (Matricaria recutita L.) inhibited compound 48/80-induced itch-scratch responses in mice
    Y Kobayashi
    Kyowa Hakko Kogyo Co, Ltd Tsukuba Research Laboratories, Ibaraki, Japan
    Phytomedicine 10:657-64. 2003
    ..Since it is reported that an injection of compound 48/80, but not histamine, induced scratching behaviour due to itch but not to pain in ddY mice (Kuraishi et al...
  79. pmc The impact of itch symptoms in psoriasis: results from physician interviews and patient focus groups
    Denise Globe
    Amgen Inc, One Amgen Center Drive, Thousand Oaks, CA 91320, USA
    Health Qual Life Outcomes 7:62. 2009
    ....
  80. ncbi Superficial dorsal horn neurons identified by intracutaneous histamine: chemonociceptive responses and modulation by morphine
    S L Jinks
    Section of Neurobiology, Physiology and Behavior, University of California, Davis, California 95616, USA
    J Neurophysiol 84:616-27. 2000
    ..ic) delivery of histamine and other irritant chemicals, and thus might be involved in signaling sensations of itch or chemogenic pain...
  81. ncbi Treatment of pruritus with topically applied opiate receptor antagonist
    Paul L Bigliardi
    Department of Dermatology, CHUV Hôpital Beaumont, Lausanne, Switzerland
    J Am Acad Dermatol 56:979-88. 2007
    Pruritus is the most common and distressing skin symptom, and treatment of itch is a problem for thousands of people. The currently available therapies are not very effective...
  82. ncbi Ivermectin is better than benzyl benzoate for childhood scabies in developing countries
    P A Brooks
    Outpatients Department, Vila Central Hospital, Port Vila, Vanuatu
    J Paediatr Child Health 38:401-4. 2002
    ..To compare single dose oral ivermectin with topical benzyl benzoate for the treatment of paediatric scabies...
  83. ncbi Lack of efficacy of topical capsaicin in serotonin-induced itch
    E Weisshaar
    Department of Dermatology and Venereology, Otto von Guericke University Magdeburg, Germany
    Skin Pharmacol Appl Skin Physiol 13:1-8. 2000
    ..In a previous study, we showed a significantly inhibitory effect of topical CAP treatment on histamine-induced itch and cutaneous vascular reactions in healthy subjects compared to atopic eczema patients...
  84. ncbi Efficacy of naltrexone on acetylcholine-induced alloknesis in atopic eczema
    G Heyer
    Department of Dermatology, Friedrich Alexander University of Erlangen Nuremberg, Hartmannstrasse, Erlangen, Germany
    Exp Dermatol 11:448-55. 2002
    ..our present experiments similar to former experiments evaluating both peripheral cutaneous sensations and central itch procession in order to gain more information about the possible distribution of opioid receptors and their ..
  85. ncbi [Clinical effects of olopatadine hydrochloride on pruritus in skin diseases]
    Mariko Niide
    Department of Dermatology, Tokyo Medical University
    Arerugi 55:1327-36. 2006
    ..The clinical effects of second generation antihistamines on pruritus caused by various skin diseases were examined by keeping a daily record of their effects...
  86. ncbi Effectiveness of the nursing programme 'Coping with itch': a randomized controlled study in adults with chronic pruritic skin disease
    H van Os-Medendorp
    Department of Dermatology, University Medical Center Utrecht, Utrecht, The Netherlands
    Br J Dermatol 156:1235-44. 2007
    The nursing programme 'Coping with Itch' aims at reducing itch and at helping patients with chronic pruritic skin diseases cope with itch. The programme consists of educational and cognitive behavioural interventions...
  87. ncbi A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord
    Yan Gang Sun
    Department of Anesthesiology, Washington University School of Medicine Pain Center, St Louis, Missouri 63110, USA
    Nature 448:700-3. 2007
    ..Chronic itch represents a significant clinical problem resulting from renal diseases and liver diseases, as well as several ..
  88. doi Evaluation of sensory irritation caused by topical medications using a novel technique
    Annemarie Uliasz
    Department of Dermatology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Int J Dermatol 49:269-71. 2010
    ..The aim of this study was to evaluate and compare the sensory irritation caused by hydrocortisone butyrate lipocream 0.1% using a non-invasive and inexpensive technique...
  89. ncbi Inhibition of scratching behaviour caused by contact dermatitis in histidine decarboxylase gene knockout mice
    M Seike
    Department of Dermatology, Kochi Medical School, Okohcho, Nankoku Kochi, 783 8505, Japan
    Exp Dermatol 14:169-75. 2005
    A neuronal system dedicated to itch consists of primary afferent and spinothalamic projection neurons. Histamine is thought to be one of the main mediators for the transmission of itch sensation...
  90. ncbi Tacrolimus ointment 0.03% is safe and effective for the treatment of mild to moderate atopic dermatitis in pediatric patients: results from a randomized, double-blind, vehicle-controlled study
    Lawrence A Schachner
    Division of Dermatology and Cutaneous Surgery, University of Miami, Miami, Florida, USA
    Pediatrics 116:e334-42. 2005
    ..This study was designed to compare the safety and efficacy of tacrolimus ointment 0.03% with vehicle ointment for the treatment of mild to moderate atopic dermatitis (AD) in pediatric patients...
  91. ncbi Fexofenadine, an H1-receptor antagonist, partially but rapidly inhibits the itch of contact dermatitis induced by diphenylcyclopropenone in patients with alopecia areata
    Kazumoto Katagiri
    Department of Anatomy, Biology and Medicine Dermatology, Faculty of Medicine, Oita University, Oita, Japan
    J Dermatol 33:75-9. 2006
    ..However, it is unclear whether antihistamines inhibit the itch of eczematous diseases in the absence of topical corticosteroids...
  92. pmc Involvement of the BLT2 receptor in the itch-associated scratching induced by 12-(S)-lipoxygenase products in ICR mice
    H J Kim
    Laboratory of Skin Research AmorePacific Corporation R and D Center, Gyeonggi Do, Korea
    Br J Pharmacol 154:1073-8. 2008
    ....
  93. ncbi Prurigo: diagnosis and management
    Joanna Wallengren
    Department of Dermatology, University Hospital, Lund, Sweden
    Am J Clin Dermatol 5:85-95. 2004
    Prurigo is a condition of nodular cutaneous lesions that itch (pruire) intensely. Although the acute form can be caused by insect stings, most of the subacute and chronic forms appear to be idiopathic...
  94. ncbi [Swimmer's itch in Landmannalaugar, Iceland]
    Karl Skirnisson
    Institute for Experimental Pathology, University of Iceland, Keldur v Vesturlandsveg, 112 Reykjavik, Iceland
    Laeknabladid 91:729-36. 2005
    Swimmer's itch (SI) or human cercarial dermatitis is caused by free-swimming larvae of bird parasites of the family Schistosomatidae (Trematoda) which have penetrated thorough the skin...
  95. ncbi From the brain-skin connection: the neuroendocrine-immune misalliance of stress and itch
    Petra Arck
    Center for Internal Medicine and Dermatology, Charite, University Medicine Berlin, and Department of Dermatology, University Hospital Schleswig Holstein, Lubeck, Germany
    Neuroimmunomodulation 13:347-56. 2006
    ..b>Itch (pruritus) is perhaps the most common symptom associated with a majority of these inflammatory skin diseases, and ..
  96. doi Induction of leukotriene B(4) and prostaglandin E(2) release from keratinocytes by protease-activated receptor-2-activating peptide in ICR mice
    Yu Zhu
    Department of Pharmacy, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China
    Int Immunopharmacol 9:1332-6. 2009
    Protease-activated receptor-2 (PAR2) has been shown to play a key role in the pathophysiology of itch. However, the precise mechanism of PAR2-mediated itch remains largely unknown...
  97. doi Chronic pruritus: targets, mechanisms and future therapies
    Esther Pogatzki-Zahn
    Department of Anesthesiology and Intensive Care, Competence Center for the Diagnostic and Therapy of Chronic Pruritus, University of Munster, Munster, Germany
    Drug News Perspect 21:541-51. 2008
    Pruritus (itch) is an unpleasant sensation inducing the desire to scratch. Chronic pruritus (>6 weeks' duration) is a major and distressing symptom of many diseases of dermatological, systemic, neurological or psychogenic origin...
  98. ncbi [Anaphylaxis due to peach with negative ImmunoCAP result to peach allergens, including rPru p 1, rPru p 3, AND rPru p 4: a report of two cases]
    Nobuko Maeda
    Department of Dermatology, Yokohama City University
    Arerugi 58:140-7. 2009
    ..Case 1 is a 35-year-old man, who felt an itch in his oral cavity immediately after ingesting a whole fresh peach...
  99. ncbi Inhibitory effects of the methanol extract of Ganoderma lucidum on mosquito allergy-induced itch-associated responses in mice
    Tsugunobu Andoh
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan
    J Pharmacol Sci 114:292-7. 2010
    Recently, we showed that a methanol extract of Ganoderma lucidum inhibits scratching, an itch-related response, induced by intradermal injections of some pruritogens in mice. The present study investigated whether G...
  100. pmc Endocannabinoid modulation of scratching response in an acute allergenic model: a new prospective neural therapeutic target for pruritus
    Joel E Schlosburg
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 329:314-23. 2009
    Pruritus (itch) is a common cause of discomfort by dermatological disorders. Several peripherally and centrally mediated pathologies that induce pruritus do not generally respond to typical allergenic and anti-inflammatory treatments...
  101. doi Complex multipathways alterations and oxidative stress are associated with Hailey-Hailey disease
    S Cialfi
    Department of Experimental Medicine, University La Sapienza, 00161, Rome, Italy
    Br J Dermatol 162:518-26. 2010
    ..While a strong relationship exists between mutations in the gene that encodes the Ca(2+)/Mn(2+)-adenosine triphosphatase ATP2C1 and HHD, we still have little understanding of how these mutations affect manifestations of the disease...

Research Grants62

  1. Cytokine Signaling in Neurons: Inflammation, Pain and Pruritis
    Martin Steinhoff; Fiscal Year: 2013
    ..classical "neuronal" receptors and release factors that subsequently modulate the function of sensory nerves (itch, pain) are a "forefront" of neuronal signaling in the skin...
  2. Genetic Mapping Of Novel Molecular Players in Itch
    RACHEL BETH BREM; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The somatosensory system mediates pruritus, or itch, the unpleasant sensation that evokes a desire to scratch...
  3. Mei Chuan Ko; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Pruritus (itch sensation) is a symptom derived from many nervous system disorders that afflicts a large population of humans and is treated by a variety of pharmacological agents with variable success...
  4. Behavioral Pharmacology of Itch
    Mei Chuan Ko; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Pruritus (itch sensation) is a symptom derived from many nervous system disorders that afflicts a large population of humans and is treated by a variety of pharmacological agents with variable success...
  5. Ethan A Lerner; Fiscal Year: 2014
    ..It can be difficult to treat, as few specific inhibitors of itch are available and the mechanism that triggers the sensation of itch is not clear...
  6. SARAH ELIZABETH ROSS; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Chronic itch (pruritis) is a widespread condition that severely diminishes quality of life...
  7. Skin-Brain Mechanisms of Pruritus in Health and Disease
    Gil Yosipovitch; Fiscal Year: 2011
    ..Recent research has shown a central processing of experimentally-induced itch in healthy subjects but this has not been assessed in disease states as of yet...
  8. Modulation of Pruritus by Spinal Cannabinoids
    Gregory W Terman; Fiscal Year: 2010
    ..Recently, we have found that, like nociception, itch sensation, also appears to be increased in animals previously exposed to repeated morphine injections - although ..
  9. ZHOUFENG CHEN; Fiscal Year: 2016
    ..by applicant): The long-term objective of this proposal is to study the molecular mechanisms that underlie itch sensation at the spinal level...
  10. Endocannabinoid Modulation of Pruritus
    JOEL SCHLOSBURG; Fiscal Year: 2009
    Pruritus is the clinical term for itch, an unpleasant nocifensive sensation that results in the desire to scratch the affected area...
  11. Scratch-Inducing Capacity of Cholestatic Extracts
    NORA BERGASA; Fiscal Year: 2001
    ..will be used to study the scratch-inducing capacity of cholestatic extracts from patients with liver disease and itch and from rats after their central administration...
  12. SENSITIZATION OF ITCH SIGNALING NEURAL PATHWAYS
    ROBERT TUCKETT; Fiscal Year: 1992
    ..1) The afferent sensory neurons involved in signaling itch have been documented, as well as (2) a population of spinal axons that likely transmit itch-related information to ..
  13. 7th World Congress on Itch (WCI)
    Ethan A Lerner; Fiscal Year: 2013
    ..from academia, advocacy and industry, who have a shared interest in understanding the basic mechanisms of itch, its impact on people, and how it should best be managed...
  14. The Peripheral and Central Neuronal Circuits that Underlie Itch
    Hyosang Lee; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Itch, one the most distressing of dermatological symptoms, is associated with numerous skin diseases, such as atopic dermatitis, as well as with extracutaneous disorders...
  15. PAULA MARIA OLIVER; Fiscal Year: 2016
    ..We will also establish whether Ndfip1 is required for Itch ubiquitylation of TIEG1...
  16. Xinzhong Dong; Fiscal Year: 2016
    ..The goal of our research is to understand the cellular and molecular mechanisms of histamine-independent itch. Primary sensory neurons in dorsal root ganglia (DRG) play an essential role in generating itch by detecting itch ..
  17. Earl E Carstens; Fiscal Year: 2016
    b>Itch is an unpleasant sensation associated with the desire to scratch...
  18. Cellular &Inflammatory Pathways in Ashtma &Allergic Diseases: From IgE to Cells
    LAWRENCE BARRY SCHWARTZ; Fiscal Year: 2012
    ..2, how different IgEs differentially affect mast cell activation in Project 3, and how Treg cells are regulated by Itch, an E3 ubiquitin ligase, in Project 4...
  19. Tasuku Akiyama; Fiscal Year: 2014
    ..to become an independent academic researcher and to contribute to the development of new treatments for relief of itch and pain, guided by new knowledge of the mechanisms underlying these sensations...
  20. JAMES JOSEPH LEE; Fiscal Year: 2016
    ..definition of eosinophil-mediated events leading to changes in the skin that promote inflammatory symptoms such as itch responses have remained out of reach...
  21. SARAH ELIZABETH ROSS; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Chronic itch (puritis) is a severe condition that results in severely diminished quality of life...
  22. Neural Mechanisms of Itch
    ROBERT H LA MOTTE; Fiscal Year: 2013
    The neural basis of Itch is poorly understood despite its importance as a primary quality of cutaneous sensation and as a clinical symptom of many neurological and other disorders...
  23. CUTANEOUS IMMUNE RESPONSE TO PARASITIC INFECTION
    Ramaswamy Kalyanasundaram; Fiscal Year: 2000
    ..a bird schistosome which induces an acute allergic inflammatory response in the skin (commonly called 'swimmer's itch') do not appear to produce this low molecular weight factor...
  24. SPINAL MECHANISMS OF ITCH AND PAIN
    Earl Carstens; Fiscal Year: 1999
    Despite the fact that severe itch is a significant clinical problem, there is a relative absence of information about central neural mechanisms of itch compared to pain...
  25. Negative regulation of NF-kB and inflammation by TAX1BP1
    Edward W Harhaj; Fiscal Year: 2012
    ..Furthermore, we have found that TAX1BP1 recruits the HECT E3 ligase Itch to A20 via two PPXY motifs...
  26. ROBERT H LA MOTTE; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The peripheral mechanisms of inflammatory itch and pain will be studied in a mouse model of allergic contact dermatitis (ACD) in humans...
  27. Sensory C Fibers in the Upper Airways
    THOMAS EDWARD TAYLOR-CLARK; Fiscal Year: 2011
    ..Reflexes and sensations include sneezing, itch, congestion, mucus secretion, bronchospasm, altered respiratory pattern, arterial hypotension and bradycardia...
  28. John H Richburg; Fiscal Year: 2016
    ..Our preliminary data suggest that the E3 ligase, Itch, ubiquitinates c-FLIP in germ cells secondary to MEHP- induced Sertoli cell injury...
  29. Role of TIEG1 in Foxp3+Treg development and tumor progression
    VENUPRASAD K POOJARY; Fiscal Year: 2010
    ..E3 ligase Itch-mediated monoubiquitination is essential for nuclear translocation, and transcriptional activation of TIEG1...
  30. Clifford J Woolf; Fiscal Year: 2015
    ..DESCRIPTION (provided by applicant): The fundamental goal of this revised PO1 proposal is to understand how pain and itch are generated by different nociceptor and pruriceptors sensory neurons and to develop techniques that can ..
  31. B Cell Receptor Regulation of Antigen Processing
    MARCUS CLARK; Fiscal Year: 2009
    ..application, we demonstrate that the BCR constitutent Igp is ubiquitinylated at the cell surface by the E3 ligase Itch and that this is required for normal trafficking from early to late endosomes...
  32. Huang Ge Zhang; Fiscal Year: 2014
    ..We have now identified two exosomal proteins that interact with TRAF2, Itch and CSN5, which have the potential to enhance the ubiquitination of CYLD in lung tumor cells...
  33. Qiufu Ma; Fiscal Year: 2016
    ..is to identify the spinal circuits that process cutaneous somatic sensory information with a focus on pain and itch pathways...
  34. lung tumor exosome-mediated inflammation promotes tumor progression and growth
    Huang Ge Zhang; Fiscal Year: 2010
    ..We have now identified two exosomal proteins that interact with TRAF2, Itch and Jabi, which have the potential to enhance the ubiquitination of CYLD in lung tumor cells...
  35. Mechanisms of protein ubiquitination in regulating airway inflammation
    Yun Cai Liu; Fiscal Year: 2013
    ..in vivo and in vitro model systems, we recently obtained preliminary data suggesting that the E3 ubiquitin ligase Itch plays an important role in the TGF-[unreadable]-induced expression of Foxp3 and Treg- mediated proliferative ..
  36. Ardem Patapoutian; Fiscal Year: 2014
    ..is unique in perceiving stimuli both physical (temperature, mechanical) and chemical (compounds that cause pain, itch, et cetera) in nature...
  37. A PTEN-regulated ubiquitin switch controlling TRAIL sensitivity in GBM
    Russell O Pieper; Fiscal Year: 2013
    ..of FLIPs have not been described, although we have identified two involved proteins;an E3 ubiquitin ligase called AIP4 that directly interacts with, ubiquitinates, and destabilizes FLIPs, and a ubiquitin-removing enzyme called USP8 ..
  38. Role of opioid receptors in transmission of itch by spinothalamic tract neuron
    HANNAH ROSE MOSER; Fiscal Year: 2013
    PROJECT SUMMARY The use of morphine and other opioids to treat pain commonly results in severe itch. The endogenous opioid system has been implicated in the pathophysiology and treatment of several forms of chronic itch...
  39. Molecular characterization of Sensory Function
    Ardem Patapoutian; Fiscal Year: 2013
    ..is unique in perceiving stimuli both physical (temperature, mechanical) and chemical (compounds that cause pain, itch, et cetera) in nature...
  40. Itch neurons studied in vivo
    ROBERT H LA MOTTE; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Chronic itch, like chronic pain, is clinically recognized as a major cause of suffering and loss in the quality of life...
  41. Structure and Regulation of the GPCR-G Protein Interactions in the Visual System
    ARNOLD EINO RUOHO; Fiscal Year: 2011
    ..of the full-length PDEg molecule and the transducin alpha subunit (Gat) in the "GTP signaling state," in the "GDP-AIF4-transition state," and in the "RGS9/Gb5 transition state" complex...
  42. Yun Cai Liu; Fiscal Year: 2015
    ..Particularly, we have studied two critical E3 ligases Itch and Cbl-b in immune regulation and have made significant progress during the current funding period, which ..
  43. EXOCYTIC INSERTION OF POTASSIUM CHANNELS IN MEMBRANES
    William Moran; Fiscal Year: 2001
    ..are necessary for exocytic insertion of K channels into the apical membrane with microtubule inhibitors and AIF4 which activates heterotrimeric G proteins, 3) determine the effect of alanine on enterocyte volume; and 4) assess ..
  44. A screen for small molecule modulators of human GPCR MrgX1
    Xinzhong Dong; Fiscal Year: 2012
    ..of small molecular compounds for both antagonists and agonists of human MrgX1 with therapeutic implications of anti-itch and anti-chronic pain, respectively...
  45. Transmitter release from peripheral sensory neurons
    Amy B Macdermott; Fiscal Year: 2010
    The peripheral sensory nerves specialized for detection of noxious stimuli, temperature and itch have their peripheral terminals in the skin, muscle, bone and viscera, their cell bodies in the dorsal root ganglion (DRG), and their central ..
  46. ORGANIZATION OF THE LAMINA I STT PROJECTION
    Arthur Craig; Fiscal Year: 1999
    ..The thermal grill and the itch-inducing agent histamine will also be used to examine whether the postulated integration of lamina I STT activity ..
  47. Manipulation of T cell tolerance with small organic mol*
    Anjana Rao; Fiscal Year: 2005
    ..that induce or inhibit T cell anergy by targeting the transcription factor NFAT and the E3 ubiquitin ligase Itch, respectively...
  48. PROPERTIES OF LABELED SUBSTANTIA GELATINOSA NEURONS
    ADAM HANTMAN; Fiscal Year: 2005
    ..the spinal cord would help clarify normal and pathological functions of somatosensory systems associated with pain, itch temperature, and some forms of touch...
  49. Evaluation in Primates of Cocaine Esterase for the Treatment of Cocaine Toxicity
    Mei Chuan Ko; Fiscal Year: 2010
    ..Dose-response functions for each enzyme will be obtained repeatedly and blood samples analyzed for titer development so that tolerance to the effects of CocE can be monitored. ..
  50. Intrathecal Opioid-Induced Pruritus
    Mei Chuan Ko; Fiscal Year: 2003
    ..Compared with the literature on pain research, there is a deficiency of itch research related to spinal opioids. This may be due, in part, to lack of reliable animal models...
  51. Central Nerual Mechanisms Involved in the Control of Itch
    Steve Davidson; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Itch is a major clinical problem from which relief is sought by patients suffering from a variety of diseases and infections...
  52. Lamina I and Homeostasis
    Arthur Craig; Fiscal Year: 2005
    ..The fundamental knowledge will provide new opportunities for explaining maladaptive homeostatic responses to somatic physiological changes, including such human pathological conditions as fibromyalgia. ..
  53. Physiology of Lamina I and V STT Cells
    Arthur Craig; Fiscal Year: 2005
    The spinothalamic tract (STT) is an important ascending pathway for activity associated with pain, temperature and itch sensations in primates and humans...
  54. Fine Structure of Lamina I TSST Terminals in VP
    Arthur Craig; Fiscal Year: 2004
    ..and humans (VMpo) that, we believe, serves as a specific thalamocortical relay nucleus for pain, temperature, itch and other sensations related to the physiological condition of the body...
  55. Neurite density in skin as a marker for neuropathic pain
    Anne Louise Oaklander; Fiscal Year: 2005
    ..abstract_text> ..
  56. BioMarker Analysis from Single Cells using Nanobiosensor
    Mark Adams; Fiscal Year: 2007
    ..is enabled by "NanoArrayer" technology developed by the applicant institution for the construction of biochips w itch ultramicro (1-20 mm) to submicron (250 nm) spatial addresses (corresponding to 1/1000th - 1/10,000th of the surface ..
  57. CBL IN T CELL ACTIVATION
    Yun Cai Liu; Fiscal Year: 2006
    ..abstract_text> ..
  58. Cb1-b in T Cell Activation and Tolerance
    Yun Cai Liu; Fiscal Year: 2006
    ....
  59. Satellite Glial and Sensory Coding: Implications for Pain
    ROBERT LA MOTTE; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  60. PARTIAL RHIZOTOMY EFFECTS ON SPINAL GANGLIA
    ROBERT LA MOTTE; Fiscal Year: 2002
    ....
  61. NEURAL MECHANISMS FOR THE TACTUAL PERCEPTION OF SOFTNESS
    ROBERT LA MOTTE; Fiscal Year: 2002
    ....
  62. Regulation on Immune Responses by Itch
    Yun Cai Liu; Fiscal Year: 2002
    ..b>Itch, a novel E3 Ub ligase, is absent in the non-agouti-lethal 18H mice, or Itchy mice...