IRF6

Summary

Gene Symbol: IRF6
Description: interferon regulatory factor 6
Alias: LPS, OFC6, PIT, PPS, PPS1, VWS, VWS1, interferon regulatory factor 6
Species: human

Top Publications

  1. pmc Mediation by nitric oxide formation in the preoptic area of endotoxin and tumour necrosis factor-induced inhibition of water intake in the rat
    G Calapai
    Institute of Pharmacology, Faculty of Medicine, University of Messina, Italy
    Br J Pharmacol 111:1328-32. 1994
  2. ncbi Influence of salbutamol and isoproterenol on the production of TNF and reactive oxygen species by bovine alveolar macrophages and calcitriol differentiated HL-60 cells
    Y Gu
    Forschungszentrum Karlsruhe, Technik und Umwelt, , Germany
    Immunopharmacol Immunotoxicol 18:115-28. 1996
  3. ncbi Lip pits and deletion 1q32----41
    M Bocian
    Am J Med Genet 26:437-43. 1987
  4. pmc Mutations in IRF6 cause Van der Woude and popliteal pterygium syndromes
    Shinji Kondo
    Department of Pediatrics, The University of Iowa, Iowa City, Iowa 52242, USA
    Nat Genet 32:285-9. 2002
  5. ncbi Interferon regulatory factor 6 (IRF6) gene variants and the risk of isolated cleft lip or palate
    Theresa M Zucchero
    University of Iowa, Iowa City 52242, USA
    N Engl J Med 351:769-80. 2004
  6. pmc Significant association between IRF6 820G->A and non-syndromic cleft lip with or without cleft palate in the Thai population
    C Srichomthong
    Division of Medical Genetics and Metabolism, Department of Paediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    J Med Genet 42:e46. 2005
  7. ncbi Interferon regulatory factor-6: a gene predisposing to isolated cleft lip with or without cleft palate in the Belgian population
    Michella Ghassibe
    Laboratory of Human Molecular Genetics, Christian de Duve Institute of Cellular Pathology and University of Louvain Medical School, Brussels, Belgium
    Eur J Hum Genet 13:1239-42. 2005
  8. ncbi Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch
    Rebecca J Richardson
    Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Nat Genet 38:1329-34. 2006
  9. pmc Association between IRF6 and nonsyndromic cleft lip with or without cleft palate in four populations
    Ji Wan Park
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA, and Department of Medical Research and Craniofacial Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Genet Med 9:219-27. 2007
  10. ncbi Interferon regulatory factor 6 (IRF6) is associated with oral-facial cleft in individuals that originate in South America
    Alexandre R Vieira
    Department of Oral Biology and Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Am J Med Genet A 143:2075-8. 2007

Research Grants

  1. Pathogenic Mechanisms of Shiga Toxins
    Vernon L Tesh; Fiscal Year: 2010
  2. CELLULAR ACTIVATION MECHANISMS IN SEPTIC SHOCK
    Peter S Tobias; Fiscal Year: 2012
  3. Identification of age-related mediators of pro-inflammatory signaling
    AMANDA OPALUCH; Fiscal Year: 2010
  4. Seena Ajit; Fiscal Year: 2014
  5. Mechanisms of abnormal enterochromaffin cell secretion in Crohn's disease
    Mark S Kidd; Fiscal Year: 2012
  6. Novel approaches to attenuate lipopolysaccharide-induced inflammation
    Ramesh K Ganju; Fiscal Year: 2012
  7. Thomas Y Ma; Fiscal Year: 2015
  8. Geert Jan Boons; Fiscal Year: 2014
  9. David S Pasco; Fiscal Year: 2014
  10. Keiko Watanabe; Fiscal Year: 2015

Detail Information

Publications760 found, 100 shown here

  1. pmc Mediation by nitric oxide formation in the preoptic area of endotoxin and tumour necrosis factor-induced inhibition of water intake in the rat
    G Calapai
    Institute of Pharmacology, Faculty of Medicine, University of Messina, Italy
    Br J Pharmacol 111:1328-32. 1994
    ..coli endotoxin (LPS, 640 micrograms kg-1, i.v.) and tumour necrosis factor (TNF alpha, 40 ng, i.c.v.) in 24 h water-deprived rats. 3...
  2. ncbi Influence of salbutamol and isoproterenol on the production of TNF and reactive oxygen species by bovine alveolar macrophages and calcitriol differentiated HL-60 cells
    Y Gu
    Forschungszentrum Karlsruhe, Technik und Umwelt, , Germany
    Immunopharmacol Immunotoxicol 18:115-28. 1996
    ..The superoxide anion production was stimulated by Zymosan, the TNF release by LPS. By incubation with 5 x 10(-6) and 5 x 10(-7) M Salbutamol or 5 x 10(-7) and 5 x 10(-8) M Isoproterenol prior to ..
  3. ncbi Lip pits and deletion 1q32----41
    M Bocian
    Am J Med Genet 26:437-43. 1987
    ..To our knowledge, interstitial deletion of the segment 1q32----41 has not been reported. This observation raises the possibility that the van der Woude syndrome may be due to a submicroscopic deletion of chromosome 1q...
  4. pmc Mutations in IRF6 cause Van der Woude and popliteal pterygium syndromes
    Shinji Kondo
    Department of Pediatrics, The University of Iowa, Iowa City, Iowa 52242, USA
    Nat Genet 32:285-9. 2002
    b>Interferon regulatory factor 6 (IRF6) belongs to a family of nine transcription factors that share a highly conserved helix-turn-helix DNA-binding domain and a less conserved protein-binding domain...
  5. ncbi Interferon regulatory factor 6 (IRF6) gene variants and the risk of isolated cleft lip or palate
    Theresa M Zucchero
    University of Iowa, Iowa City 52242, USA
    N Engl J Med 351:769-80. 2004
    ..We searched for a specific genetic factor contributing to this complex trait by examining large numbers of affected patients and families and evaluating a specific candidate gene...
  6. pmc Significant association between IRF6 820G->A and non-syndromic cleft lip with or without cleft palate in the Thai population
    C Srichomthong
    Division of Medical Genetics and Metabolism, Department of Paediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    J Med Genet 42:e46. 2005
    Previous data have shown an association between DNA sequence variants in the IRF6 gene and an increased risk of non-syndromic cleft lip with or without cleft palate (CL/P) in some populations.
  7. ncbi Interferon regulatory factor-6: a gene predisposing to isolated cleft lip with or without cleft palate in the Belgian population
    Michella Ghassibe
    Laboratory of Human Molecular Genetics, Christian de Duve Institute of Cellular Pathology and University of Louvain Medical School, Brussels, Belgium
    Eur J Hum Genet 13:1239-42. 2005
    ..The interferon regulatory factor-6 (IRF6) gene has been shown to harbor mutations in patients with van der Woude syndrome, a dominant form of clefts ..
  8. ncbi Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch
    Rebecca J Richardson
    Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Nat Genet 38:1329-34. 2006
    ..Here, we show that mice carrying a homozygous missense mutation in interferon regulatory factor 6 (Irf6), the homolog of the gene mutated in the human congenital disorders Van der Woude syndrome and ..
  9. pmc Association between IRF6 and nonsyndromic cleft lip with or without cleft palate in four populations
    Ji Wan Park
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA, and Department of Medical Research and Craniofacial Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Genet Med 9:219-27. 2007
    The interferon regulatory factor 6 (IRF6), the gene that causes van der Woude syndrome has been shown to be associated with nonsyndromic cleft lip with or without palate in several populations...
  10. ncbi Interferon regulatory factor 6 (IRF6) is associated with oral-facial cleft in individuals that originate in South America
    Alexandre R Vieira
    Department of Oral Biology and Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Am J Med Genet A 143:2075-8. 2007
  11. pmc Interferon regulatory factor 6 promotes cell cycle arrest and is regulated by the proteasome in a cell cycle-dependent manner
    Caleb M Bailey
    Children s Memorial Research Center, 2300 Children s Plaza, Box 222, Chicago, IL 60614 3394, USA
    Mol Cell Biol 28:2235-43. 2008
    b>Interferon regulatory factor 6 (IRF6) is a novel and unique member of the IRF family of transcription factors...
  12. pmc Genetic variants in IRF6 and the risk of facial clefts: single-marker and haplotype-based analyses in a population-based case-control study of facial clefts in Norway
    Astanand Jugessur
    Section for Epidemiology and Medical Statistics, Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway
    Genet Epidemiol 32:413-24. 2008
    Mutations in the gene encoding interferon regulatory factor 6 (IRF6) underlie a common form of syndromic clefting known as Van der Woude syndrome...
  13. pmc Disruption of an AP-2alpha binding site in an IRF6 enhancer is associated with cleft lip
    Fedik Rahimov
    Department of Pediatrics, University of Iowa, 2182 ML, S Grand Ave, Iowa City, Iowa 52242, USA
    Nat Genet 40:1341-7. 2008
    ..nonsyndromic cleft lip with or without cleft palate (NSCL/P) is strongly associated with SNPs in IRF6 (interferon regulatory factor 6)...
  14. pmc Missense mutations that cause Van der Woude syndrome and popliteal pterygium syndrome affect the DNA-binding and transcriptional activation functions of IRF6
    Hayley J Little
    Faculty of Life Sciences, Michael Smith Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Hum Mol Genet 18:535-45. 2009
    ..CLP, lip pits, skin-folds, syndactyly and oral adhesions which arise as the result of mutations in interferon regulatory factor 6 (IRF6)...
  15. doi Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24
    Stefanie Birnbaum
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Nat Genet 41:473-7. 2009
    ..05 (95% CI = 3.88-9.43) for the homozygous genotype. The calculated population attributable risk for this marker is 0.41, suggesting that this study has identified a major susceptibility locus for NSCL/P...
  16. pmc Prevalence and nonrandom distribution of exonic mutations in interferon regulatory factor 6 in 307 families with Van der Woude syndrome and 37 families with popliteal pterygium syndrome
    Renata L L Ferreira de Lima
    Serviço de Aconselhamento Genético, UNESP, Botucatu, Sao Paulo, Brazil
    Genet Med 11:241-7. 2009
    b>Interferon regulatory factor 6 encodes a member of the IRF family of transcription factors. Mutations in interferon regulatory factor 6 cause Van der Woude and popliteal pterygium syndrome, two related orofacial clefting disorders...
  17. doi Association among IRF6 polymorphism, environmental factors, and nonsyndromic orofacial clefts in western china
    Zhong Lin Jia
    State Key Laboratory of Oral Disease and the Department of Cleft Lip and Palate Surgery, West China College of Stomatology, Sichuan University, Chengdu 610041, People s Republic of China
    DNA Cell Biol 28:249-57. 2009
    The interferon regulatory factor 6 (IRF6) gene and environmental factors have been shown to be associated with nonsyndromic cleft lip with or without cleft palate (NSCL/P) in several populations...
  18. pmc Association between IRF6 SNPs and oral clefts in West China
    Y Huang
    State Key Laboratory of Oral Disease, West China College of Stomatology, Sichuan University, Chengdu 610041, P R China
    J Dent Res 88:715-8. 2009
    Analyses of previous data have confirmed the contribution of the IRF6 gene to susceptibility to non- syndromic oral clefts (NSOC) in some populations...
  19. doi Three novel mutations of the IRF6 gene with one associated with an unusual feature in Van der Woude syndrome
    Patra Yeetong
    Graduate School, Inter Department Program of Biomedical Science, Chulalongkorn University, Bangkok, Thailand
    Am J Med Genet A 149:2489-92. 2009
    ..It remains the most common syndromic form of oral clefts. Mutations in the interferon regulatory factor 6 (IRF6) gene have been identified in patients with VWS...
  20. pmc Testing reported associations of genetic risk factors for oral clefts in a large Irish study population
    Tonia C Carter
    Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Birth Defects Res A Clin Mol Teratol 88:84-93. 2010
    ..a large, ethnically homogenous study population to test whether reported associations between nonsyndromic oral clefts and 12 genes (CLPTM1, CRISPLD2, FGFR2, GABRB3, GLI2, IRF6, PTCH1, RARA, RYK, SATB2, SUMO1, TGFA) could be confirmed.
  21. doi Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate
    Elisabeth Mangold
    Institute of Human Genetics, Life and Brain Center, University of Bonn, Bonn, Germany
    Nat Genet 42:24-6. 2010
    ..07 x 10(-8), relative risk in homozygotes = 1.84, 95% CI 1.34-2.53) and 10q25.3 (rs7078160, combined P = 1.92 x 10(-8), relative risk in homozygotes = 2.17, 95% CI 1.32-3.56)...
  22. doi IRF6 gene variants in Central European patients with non-syndromic cleft lip with or without cleft palate
    Stefanie Birnbaum
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Eur J Oral Sci 117:766-9. 2009
    Variants in the interferon regulatory factor 6 (IRF6) gene have repeatedly been associated with non-syndromic cleft lip with or without cleft palate (NSCL/P)...
  23. pmc A regulatory feedback loop involving p63 and IRF6 links the pathogenesis of 2 genetically different human ectodermal dysplasias
    Francesca Moretti
    Department of Dermatology, University of Rome Tor Vergata, Rome, Italy
    J Clin Invest 120:1570-7. 2010
    ..Mutations in the p63 and interferon regulatory factor 6 (IRF6) genes have been found in human patients with these syndromes, consistent with phenotypes...
  24. pmc A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4
    Terri H Beaty
    Johns Hopkins University, School of Public Health, Baltimore, Maryland, USA
    Nat Genet 42:525-9. 2010
    ..432, 95% CI 1.292-1.587, P = 5.01 x 10(-12)) and two previously identified regions (at chromosome 8q24 and IRF6) attained genome-wide significance...
  25. pmc Evidence of gene-environment interaction for the IRF6 gene and maternal multivitamin supplementation in controlling the risk of cleft lip with/without cleft palate
    Tao Wu
    Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Hum Genet 128:401-10. 2010
    ..non-syndromic cleft lip with/without cleft palate (CL/P), a complex and heterogeneous birth defect, interferon regulatory factor 6 gene (IRF6) is one of the best documented genetic risk factors...
  26. doi IRF6 mutations in mixed isolated familial clefting
    Katherine D Rutledge
    Department of Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Am J Med Genet A 152:3107-9. 2010
    Mutations in the interferon regulatory factor 6 (IRF6) gene are known to cause van der Woude syndrome (VWS), a common syndromic form of oro-facial clefting characterized by the familial occurrence of mixed clefting (cleft lip with or ..
  27. pmc Developmental factor IRF6 exhibits tumor suppressor activity in squamous cell carcinomas
    Elisabetta Botti
    Department of Dermatology, University of Rome Tor Vergata, 00133 Rome, Italy
    Proc Natl Acad Sci U S A 108:13710-5. 2011
    The transcription factor interferon regulatory factor 6 (IRF6) regulates craniofacial development and epidermal proliferation...
  28. pmc Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci
    Kerstin U Ludwig
    Institute of Human Genetics, University of Bonn, Germany
    Nat Genet 44:968-71. 2012
    ..51 × 10(-11); homozygote relative risk = 2.41, 95% confidence interval (CI) 1.84-3.16)...
  29. doi IRF6 is a risk factor for nonsyndromic cleft lip in the Brazilian population
    Luciano A Brito
    Human Genome Research Center, Department of Genetics, Institute de Biosciences, University of Sao Paulo, Sao Paulo, Brazil
    Am J Med Genet A 158:2170-5. 2012
    ..Among the putative susceptibility loci, the IRF6 gene and a region at 8q24.21 have been corroborated in different populations...
  30. pmc A preliminary gene map for the Van der Woude syndrome critical region derived from 900 kb of genomic sequence at 1q32-q41
    B C Schutte
    Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242 USA
    Genome Res 10:81-94. 2000
    Van der Woude syndrome (VWS) is a common form of syndromic cleft lip and palate and accounts for approximately 2% of all cleft lip and palate cases...
  31. ncbi Novel IRF6 mutations in Japanese patients with Van der Woude syndrome: two missense mutations (R45Q and P396S) and a 17-kb deletion
    Shuji Kayano
    Department of Medical Genetics, Tohoku University School of Medicine, Seiryomachi, Aoba ku, Sendai 980 8574, Japan
    J Hum Genet 48:622-8. 2003
    Three Japanese families with Van der Woude syndrome (VWS) were screened for mutations in the interferon regulatory factor 6 gene (IRF6) by sequencing its entire coding region...
  32. pmc Six families with van der Woude and/or popliteal pterygium syndrome: all with a mutation in the IRF6 gene
    M Ghassibe
    Laboratory of Human Molecular Genetics, Christian de Duve Institute of Cellular Pathology and Universite catholique de Louvain, Avenue Hippocrate 74 4, Brussels, Belgium
    J Med Genet 41:e15. 2004
  33. ncbi Van Der Woude syndrome: variable penetrance of a novel mutation (p.Arg 84Gly) of the IRF6 gene in a Turkish family
    Chike Bellarmine Item
    University Hospital of Cranio Maxillofacial and Oral Surgery, Medical University of Vienna, A 1090 Vienna, Austria
    Int J Mol Med 15:247-51. 2005
    ..Mutations of the interferon regulatory factor 6 gene (IRF6) have been recently described in patients with VWS...
  34. pmc Interferon regulatory factor 6 (IRF6) and fibroblast growth factor receptor 1 (FGFR1) contribute to human tooth agenesis
    Alexandre R Vieira
    Department of Oral Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Med Genet A 143:538-45. 2007
    ..We investigated two genes responsible for craniofacial syndromes, FGFR1 and IRF6, in a collection of families with isolated tooth agenesis...
  35. ncbi A novel IRF6 nonsense mutation (Y67X) in a German family with Van der Woude syndrome
    Sibylle Brosch
    Section of Phoniatrics and Pedaudiology, Department of Otolaryngology, University of Ulm, Ulm, Germany
    Int J Mol Med 20:85-9. 2007
    ..VWS arises as the result of mutations in the gene encoding interferon regulatory factor 6 (IRF6)...
  36. doi Evidence of linkage disequilibrium between polymorphisms at the IRF6 locus and isolate tooth agenesis, in a Turkish population
    Alexandre R Vieira
    Department of Oral Biology and Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsbergh, PA 15261, USA
    Arch Oral Biol 53:780-4. 2008
    Recently, the IRF6 contribution that was reported for Van der Woude syndrome and non-syndromic oral clefts was extended to isolated tooth agenesis...
  37. ncbi Identification of IRF6 gene variants in three families with Van der Woude syndrome
    Ene Choo Tan
    KK Research Centre, KK Women s and Children s Hospital, Singapore 229899, Singapore
    Int J Mol Med 21:747-51. 2008
    ..Several mutations in the interferon regulatory factor 6 (IRF6) gene have been found in VWS families, suggesting that this gene is the primary locus...
  38. doi Epidemiology of Van der Woude syndrome from mutational analyses in affected patients from Pakistan
    S Malik
    School of Biological Sciences, Department of Microbiology and Molecular Genetics, University of the Punjab, Lahore, Pakistan
    Clin Genet 78:247-56. 2010
    Mutations in IRF6 cause Van der Woude syndrome (VWS), one of the most common syndromes associated with cleft lip (CL) with or without cleft palate (CP)...
  39. doi Association between genetic variants of reported candidate genes or regions and risk of cleft lip with or without cleft palate in the polish population
    Adrianna Mostowska
    Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Poland
    Birth Defects Res A Clin Mol Teratol 88:538-45. 2010
    ..Because of the genetic heterogeneity of facial clefts, the aim of this study was to investigate the contribution of previously reported candidate genes and chromosomal loci to the risk of CL/P in the Polish population...
  40. doi Genetic risk factors for nonsyndromic cleft lip with or without cleft palate in a Mesoamerican population: Evidence for IRF6 and variants at 8q24 and 10q25
    Augusto Rojas-Martinez
    Department of Biochemistry and Molecular Medicine, Universidad Autonoma de Nuevo Leon, Monterrey, Mexico
    Birth Defects Res A Clin Mol Teratol 88:535-7. 2010
    ..NSCL/P has a multifactorial etiology that includes both genetic and environmental factors. The IRF6 gene and three further susceptibility loci at 8q24, 10q25, and 17q22, which were identified by a recent genome-wide ..
  41. doi MTHFR and MSX1 contribute to the risk of nonsyndromic cleft lip/palate
    Triin Jagomagi
    Department of Stomatology, Faculty of Medicine, University of Tartu, Tartu, Estonia
    Eur J Oral Sci 118:213-20. 2010
    ..Epistatic interactions were observed for SNPs within PVRL2, between BCL3 and EDN1, and between IRF6 and MSX1 genes...
  42. doi IRF6 polymorphisms are associated with nonsyndromic orofacial clefts in a Chinese Han population
    Yongchu Pan
    Institute of Stomatology, Department of Epidemiology, Nanjing Medical University, Nanjing, China
    Am J Med Genet A 152:2505-11. 2010
    b>IRF6 plays an important role in orofacial development...
  43. doi Two missense mutations of the IRF6 gene in two Japanese families with popliteal pterygium syndrome
    Noriko Matsuzawa
    Department of Oral and Maxillofacial Surgery, Okazaki City Hospital, Okazaki, Japan
    Am J Med Genet A 152:2262-7. 2010
    Mutations in the interferon regulatory factor 6 gene (IRF6) cause either popliteal pterygium syndrome (PPS) or Van der Woude syndrome (VWS), allelic autosomal dominant orofacial clefting conditions...
  44. doi Two novel mutations affecting splicing in the IRF6 gene associated with van der Woude syndrome
    Anna Paola Scioletti
    Department of Clinical Sciences and Bioimages, G D Annunzio University, Chieti Pescara, Italy
    J Craniofac Surg 21:1654-6. 2010
    ..Different studies have demonstrated an association between VWS and mutations of the IRF6 (interferon regulatory factor) gene...
  45. doi Association of common variants, not rare mutations, in IRF6 with nonsyndromic clefts in a Honduran population
    Yuna C Larrabee
    Columbia University College of Physicians and Surgeons, New York, New York, USA
    Laryngoscope 121:1756-9. 2011
    ..Linkage studies have shown interferon regulatory factor 6 (IRF6) to be associated with CL/P in multiple populations, including one in Honduras...
  46. doi Breakthroughs in the genetics of orofacial clefting
    Elisabeth Mangold
    Institute of Human Genetics, University of Bonn, Sigmund Freud Str 25, 53127 Bonn, Germany
    Trends Mol Med 17:725-33. 2011
    ..and candidate gene studies have attempted to elucidate the underlying genetic architecture, only the interferon regulatory factor 6 (IRF6) gene has been identified as causative...
  47. doi Mutation screening of IRF6 among families with non-syndromic oral clefts and identification of two novel variants: review of the literature
    Iman Salahshourifar
    Human Genome Center, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia
    Eur J Med Genet 55:389-93. 2012
    ..Thus, about 15% of VWS cases are indistinguishable from cases with non-syndromic oral clefts. IRF6 mutations are the major cause of VWS; however, variants in this gene show strong association with non-syndromic ..
  48. doi [Association between polymorphism of IRF6 rs2235371 locus and nonsyndromic cleft lip with or without cleft palate]
    Meng Jie Li
    Department of Nutrition and Food Hygiene, Peking University, Beijing, People s Republic of China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 29:149-54. 2012
    To assess the association between polymorphism of interferon regulatory factor 6 (IRF6) gene rs2235371 locus and nonsyndromic cleft lip with or without cleft palate in Chinese population.
  49. pmc Interaction between IRF6 and TGFA genes contribute to the risk of nonsyndromic cleft lip/palate
    Ariadne Letra
    Department of Oral Biology, University of Pittsburgh, School of Dental Medicine, Pittsburgh, PA, USA
    PLoS ONE 7:e45441. 2012
    Previous evidence from tooth agenesis studies suggested IRF6 and TGFA interact...
  50. pmc Popliteal pterygium syndrome: a clinical study of three families and report of linkage to the Van der Woude syndrome locus on 1q32
    M M Lees
    Department of Clinical Genetics, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    J Med Genet 36:888-92. 1999
    ..PPS has some features in common with Van der Woude syndrome (VWS), also inherited as an autosomal dominant condition, with cleft lip/palate and, more distinctively, lower lip pits...
  51. pmc Effects of macrophage depletion on the induction of histidine decarboxylase by lipopolysaccharide, interleukin 1 and tumour necrosis factor
    Y Endo
    Department of Pharmacology, School of Dentistry, Tohoku University, Sendai, Japan
    Br J Pharmacol 114:187-93. 1995
    1. Our previous work has shown that injection into mice of lipopolysaccharide (LPS) and the cytokines interleukin 1 (IL-1) and tumour necrosis factor (TNF) induces histidine decarboxylase (HDC), the enzyme forming histamine, in various ..
  52. pmc Induction of cyclo-oxygenase-2 by cytokines in human pulmonary epithelial cells: regulation by dexamethasone
    J A Mitchell
    Department of Applied Pharmacology, National Heart and Lung Institute, London
    Br J Pharmacol 113:1008-14. 1994
    ..Cyclo-oxygenase-1 (COX-1) is expressed constitutively whereas COX-2 is induced by lipopolysaccharide (LPS) and some cytokines in vitro and at the site of inflammation in vivo...
  53. pmc Characterization of the induction of nitric oxide synthase and cyclo-oxygenase in rat aorta in organ culture
    D Bishop Bailey
    Department of Applied Pharmacology, National Heart and Lung Institute, Imperial College of Science and Technology, London
    Br J Pharmacol 121:125-33. 1997
    ..In each case, segments from the same animal were left untreated or treated with bacterial lipopolysaccharide (LPS; 10 micrograms ml-1) in order to induce iNOS and COX-2...
  54. ncbi Species differences in sequence and activity of the peroxisome proliferator response element (PPRE) within the acyl CoA oxidase gene promoter
    K G Lambe
    Cancer Biology Group, AstraZeneca Central Toxicology Laboratory, Macclesfield, UK
    Toxicol Lett 110:119-27. 1999
    ..However, humans appear to be non-responsive to the adverse effects of PPs such as ACO induction...
  55. ncbi [Detection of bactericidal antibody in the breast milk of a mother infected with enterohemorrhagic Escherichia coli O157:H7]
    E Adachi
    Department of Infectious Diseases Research, National Children's Medical Research Center
    Kansenshogaku Zasshi 73:451-6. 1999
    ..Anti-E. coli O157 LPS antibodies (IgA, G and M) were assayed by the ELISA method...
  56. pmc The inhibitory effects of mercaptoalkylguanidines on cyclo-oxygenase activity
    B Zingarelli
    Division of Critical Care Medicine, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Br J Pharmacol 120:357-66. 1997
    ..Immunostimulation of the J774 macrophages by endotoxin (lipopolysaccharide of E. coli, LPS 10 micrograms ml-1) and interferon gamma (IFN gamma, 100 u ml-1) for 6 h resulted in a significant induction of COX-..
  57. pmc Drug modulation of antigen-induced paw oedema in guinea-pigs: effects of lipopolysaccharide, tumour necrosis factor and leucocyte depletion
    J I da Motta
    Department of Pharmacology, , Brazil
    Br J Pharmacol 112:111-6. 1994
    ..5. Intravenous injection of lipopolysaccharide (LPS) dose-dependently inhibited the oedema induced by ovalbumin (200 micrograms/paw)...
  58. ncbi Selective inhibition of E-selectin, vascular cell adhesion molecule-1, and intercellular adhesion molecule-1 expression by inhibitors of I kappa B-alpha phosphorylation
    C C Chen
    Upjohn Laboratories, Kalamazoo, MI 49001, USA
    J Immunol 155:3538-45. 1995
    ..Inhibition of I kappa B-alpha proteolysis resulted in the inhibition of the cytokine- and LPS-induced transcriptional up-regulation and cell-surface expression of E-selectin, VCAM-1, and ICAM-1...
  59. ncbi Unique renal tubule changes induced in rats and mice by the peroxisome proliferators 2,4-dichlorophenoxyacetic acid (2,4-D) and WY-14643
    K Ozaki
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 29:440-50. 2001
    ..The National Toxicology Program (NTP) conducted a study of several peroxisome proliferators (PPs), including Wyeth (WY)-14643 as a prototypical PP and 2,4-dichlorophenoxyacetic acid (2,4-D) as a weak PP, in ..
  60. ncbi The prophylactic effects of natural water-soluble antioxidant from spinach and apocynin in a rabbit model of lipopolysaccharide-induced endotoxemia
    L Lomnitski
    Bar Ilan University, Ramat Gan, Israel
    Toxicol Pathol 28:588-600. 2000
    ..In previous studies we demonstrated that endotoxin lipopolysaccharide (LPS) promotes oxidative stress and associated pathological changes in a rat model and that use of selected antioxidants ..
  61. pmc Involvement of tyrosine kinase in the induction of cyclo-oxygenase and nitric oxide synthase by endotoxin in cultured cells
    P Akarasereenont
    William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
    Br J Pharmacol 113:1522-8. 1994
    ..role of tyrosine kinase activation in the induction on COX-2 and iNOS caused by endotoxin (lipopolysaccharide; LPS) in bovine aortic endothelial cells (BAEC) and J774.2 macrophages. 2...
  62. ncbi [Study of neutrophil dysfunctions in the elderly using a chemiluminescence method]
    M Aoki
    Second Department of Internal Medicine, Teikyo University School of Medicine
    Kansenshogaku Zasshi 68:1367-75. 1994
    ..Furthermore, I evaluated the priming effect of lipopolysaccharide (LPS) and tumor necrosis factor-alpha (TNF-alpha) on whole blood CL...
  63. pmc The influence of antibodies to TNF-alpha and IL-1beta on haemodynamic responses to the cytokines, and to lipopolysaccharide, in conscious rats
    S M Gardiner
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre
    Br J Pharmacol 125:1543-50. 1998
    ..a mixture of the antibodies to TNF-alpha and IL-1beta had any influence on the responses to lipopolysaccharide (LPS)...
  64. ncbi Enhanced interleukin-1beta, interleukin-6 and tumor necrosis factor-alpha production by LPS stimulated human monocytes isolated from HIV+ patients
    A A Baqui
    Department of Oral Medicine, Dental School University of Maryland, Baltimore 21201, USA
    Immunopharmacol Immunotoxicol 22:401-21. 2000
    ..In addition to local oral lipopolysaccharide (LPS) stimulation, systemic up-regulation of monocyte pro-inflammatory cytokine secretion may also be involved in the ..
  65. pmc Inhibition by N-acetyl-5-hydroxytryptamine of nitric oxide synthase expression in cultured cells and in the anaesthetized rat
    P Klemm
    William Harvey Research Institute, St Bartholomew s Hospital Medical College, Charterhouse Square, London
    Br J Pharmacol 115:1175-81. 1995
    ..macrophages and smooth muscle cells in vitro, and on the hypotensive response to bacterial lipopolysaccharide (LPS) in the anaesthetized rat in vivo. 2. NAS (0...
  66. ncbi [An outbreak of waterborne Cryptosporidiosis in Kanagawa, Japan]
    T Kuroki
    Department of Bacteriology and Pathology, Kanagawa Prefectural Public Health Laboratory
    Kansenshogaku Zasshi 70:132-40. 1996
    ..was directly connected with the public waterworks, and an elevated tank on the roof, a wastewater pits, a soil pit and artesianspring water tank...
  67. ncbi Tannins and related compounds: killing of amastigotes of Leishmania donovani and release of nitric oxide and tumour necrosis factor alpha in macrophages in vitro
    A F Kiderlen
    Robert Koch Institut, , Berlin, Germany
    Z Naturforsch C 56:444-54. 2001
    ..potential of the test compounds for its release was found to be very moderate ranging from 7-54 microM (IFN-gamma/LPS 119 microM)...
  68. pmc Effect of interleukin-4 and interleukin-10 on leucocyte migration and nitric oxide production in the mouse
    M Perretti
    Department of Biochemical Pharmacology, William Harvey Research Institute, Medical College of St Bartholomew s Hospital, London
    Br J Pharmacol 116:2251-7. 1995
    ..3. Treatment of mice with lipopolysaccharide (LPS, 0.3 mg kg-1, i.p...
  69. ncbi Augmentation of host defense against bacterial infection pretreated intraperitoneally with an alpha-glucan RBS in mice
    Y Takeda
    Department of Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Immunopharmacol Immunotoxicol 12:457-77. 1990
    ..with expression of TNF gene in the macrophages, RBS-treated mice were less susceptible to the lethal toxicity of LPS than C.parvum-treated mice...
  70. pmc Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor
    D Riendeau
    Merck Frosst Centre for Therapeutic Research, Kirkland, Quebec, Canada
    Br J Pharmacol 121:105-17. 1997
    ..These data are consistent with a reversible competitive inhibition of COX-1. 5. DFU inhibited lipopolysaccharide (LPS)-induced PGE2 production (COX-2) in a human whole blood assay with a potency (IC50 = 0.28 +/- 0...
  71. pmc Regulation of prostaglandin production by nitric oxide; an in vivo analysis
    D Salvemini
    G D Searle, Department of Molecular Pharmacology, St Louis, MO 63167, USA
    Br J Pharmacol 114:1171-8. 1995
    1. Endotoxin E. Coli lipopolysaccharide (LPS)-treatment in conscious, restrained rats increased plasma and urinary prostaglandin (PG) and nitric oxide (NO) production...
  72. pmc Characterization of the effects of two new arginine/citrulline analogues on constitutive and inducible nitric oxide synthases in rat aorta
    G A Joly
    Department of Genitourinary Oncology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Br J Pharmacol 115:491-7. 1995
    ..5. L-TC and L-SMTC produced dose-dependent increases in tone in LPS-treated aortic rings with and without endothelium...
  73. pmc Endotoxin impairs the response of rabbit mesenteric artery to electrical stimulation via a prejunctional mechanism
    S Tomikawa
    Department of Pharmacology, Kanagawa Dental College, Japan
    Br J Pharmacol 107:826-32. 1992
    1. The effect of E. coli lipopolysaccharide (LPS) on sympathetic neuro-effector transmission was studied in the rabbit mesenteric artery...
  74. pmc Group B Streptococcus and E. coli LPS-induced NO-dependent hyporesponsiveness to noradrenaline in isolated intrapulmonary arteries of neonatal piglets
    E Villamor
    Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain
    Br J Pharmacol 115:261-6. 1995
    1. The effects of endotoxin (E. coli lipopolysaccharide, LPS) and heat inactivated group B Streptococcus (GBS) were studied on the contractile responses to noradrenaline (NA) in isolated pulmonary arteries and on the activity of the ..
  75. ncbi The role of nitric oxide in parasitic diseases
    F Y Liew
    Department of Immunology, University of Glasgow
    Ann Trop Med Parasitol 87:637-42. 1993
    ..nitric oxide (NO) when stimulated with certain cytokines in the presence of a trace amount of lipopolysaccharide (LPS)...
  76. pmc Aminoguanidine attenuates the delayed circulatory failure and improves survival in rodent models of endotoxic shock
    C C Wu
    William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
    Br J Pharmacol 114:1666-72. 1995
    ..coli lipopolysaccharide; LPS)...
  77. pmc The morphology of gastritis
    D A Owen
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada
    Yale J Biol Med 69:51-60. 1996
    ..Neutrophils are present in the surface and pit-lining epithelium...
  78. ncbi Effects of antioxidants apocynin and the natural water-soluble antioxidant from spinach on cellular damage induced by lipopolysaccaride in the rat
    L Lomnitski
    Bar Ilan University, Ramat Gan, Israel
    Toxicol Pathol 28:580-7. 2000
    Oxidative damage plays a key role in septic shock induced by the endotoxin lipopolysaccaride (LPS) by enhancing the formation of reactive oxygen species such as superoxide anion radicals, peroxides, and their secondary product, ..
  79. ncbi In vitro interleukin-8 production by monocytes treated with lithium chloride from breast cancer patients
    R A Merendino
    Department of Human Pathology, University of Messina Medical School, Italy
    Tumori 86:149-52. 2000
    ..IL-8 release was assessed in supernatants of lipopolysaccharide (LPS) and/or LiCl-treated monocyte cultures...
  80. ncbi Adherence regulates macrophage signal transduction and primes tumor necrosis factor production
    G J Bauer
    Department of Surgery, University of Washington Medical School, Seattle, USA
    Shock 14:435-40. 2000
    ..Lipopolysaccharide (LPS) activates Mphi by signaling through members of the mitogen activated protein kinase (MAPK) family thereby inducing ..
  81. pmc Up-regulation of [3H]-des-Arg10-kallidin binding to the bradykinin B1 receptor by interleukin-1 beta in isolated smooth muscle cells: correlation with B1 agonist-induced PGI2 production
    J P Galizzi
    Cerep, Celle l evescault, France
    Br J Pharmacol 113:389-94. 1994
    ..Lipopolysaccharide (LPS) treatment of the cells did not affect the B1 agonist response whereas IL-1 beta treatment produced a 7 fold ..
  82. pmc Support of renal blood flow after ischaemic-reperfusion injury by endogenous formation of nitric oxide and of cyclo-oxygenase vasodilator metabolites
    J P Cristol
    William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
    Br J Pharmacol 109:188-94. 1993
    ..In contrast to I/R, lipopolysaccaride(LPS, endotoxin; 5 mg kg-1, i.p...
  83. ncbi Induction of colony-stimulating factor(s) after administration of a traditional Chinese medicine, xiao-chai-hu-tang (Japanese name: shosaiko-to)
    K Yonekura
    Traditional Chinese Medicine Research Laboratories, Kanebo Co. Ltd, Osaka, Japan
    Immunopharmacol Immunotoxicol 12:647-67. 1990
    ..Since the serum CSF induction was observed in both lipopolysaccharide (LPS)-responder C3H/He mice and LPS-non-responder C3H/HeJ mice, the effect of shosaiko-to seemed to be independent of ..
  84. ncbi The electrogenic Na/HCO3 cotransporter
    W F Boron
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Wien Klin Wochenschr 109:445-56. 1997
    The electrogenic Na/HCO3 cotransporter (symporter) is the major HCO3- transporter of the renal proximal tubule (PiT), located at the basolateral membrane (BLM), and also plays a noteworthy role in Na+ reabsorption...
  85. ncbi Effect of recombinant human granulocyte/macrophage colony-stimulating factor on neutrophil superoxide production
    R M Schultz
    Lilly Research Laboratories, Indianapolis, IN 46285
    Immunopharmacol Immunotoxicol 13:183-98. 1991
    ..Other agents known to prime neutrophils, including LPS and tumor necrosis factor-alpha, lacked activity under the experimental conditions employed...
  86. ncbi Survival to lipopolysaccharide, cytokine release and phagocyte functions in mice treated with different total parenteral nutrition regimens
    M A Tufano
    Istituto di Microbiologia, , , Italy
    Immunopharmacol Immunotoxicol 17:493-509. 1995
    ..Survival to lipopolysaccharide (LPS) challenge, blood clearance of Escherichia coli, in vivo and in vitro production of tumor necrosis factor-alpha (..
  87. ncbi Functional maturation of immature B cells accumulated in the periphery by an intraperitoneal administration of a traditional Chinese medicine, xiao-chai-hu-tang (Japanese name: shosaiko-to)
    T Kawakita
    Kampo Research Laboratories, Kanebo Co. Ltd, Osaka, Japan
    Immunopharmacol Immunotoxicol 9:299-317. 1987
    ..In contrast, responses to trinitrophenylated lipopolysaccharide (TNP-LPS) as a TI-1 antigen and LPS as a B cell mitogen or a polyclonal B cell activator were enhanced markedly at early ..
  88. pmc Effect of anti-fungal imidazoles on mRNA levels and enzyme activity of inducible nitric oxide synthase
    R G Bogle
    Department of Pharmacology and Clinical Pharmacology, St George s Hospital Medical School, London
    Br J Pharmacol 111:1257-61. 1994
    ..2. Stimulation of J774 cells with lipopolysaccharide (LPS, 10 micrograms ml-1) resulted in the induction of NO synthase activity as determined by nitrite accumulation in the ..
  89. ncbi Potentiation of inhaled staphylococcal enterotoxin B-induced toxicity by lipopolysaccharide in mice
    R D LeClaire
    Toxinology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland 21702 5011, USA
    Toxicol Pathol 24:619-26. 1996
    ..We investigated the potentiation of staphylococcal enterotoxin B (SEB) inhalation toxicity by lipopolysaccharide (LPS) in BALB/c mice. Lethality occurred only when SEB was potentiated by LPS...
  90. ncbi [Initial results of a controlled study of small cell and squamous epithelial bronchial cancer: polychemotherapy and interferons]
    P Zabel
    Medizinische Klinik, Borstel
    Pneumologie 44:586-7. 1990
    ..In contrast, alveolar macrophages as part of local immunity show a decrease in the spontaneous and LPS-induced production of IL-1.
  91. pmc Discrimination between citrulline and arginine transport in activated murine macrophages: inefficient synthesis of NO from recycling of citrulline to arginine
    A R Baydoun
    Vascular Biology Research Centre, King s College, London
    Br J Pharmacol 112:487-92. 1994
    ..pH- and Na(+)-dependency of L-citrulline transport were examined in unstimulated and lipopolysaccharide (LPS)-activated murine macrophage J774 cells...
  92. ncbi Effect of a synthetic lipid immunomodulator on the regulation of the transcription factor NF-kappaB
    S Pollet
    , La Tronche, France
    Immunopharmacol Immunotoxicol 22:653-69. 2000
    ..Results were compared to those obtained with lipopolysaccharide (LPS) as a major virulence factor in bacterial sepsis. Data showed that exposure of J774...
  93. ncbi Anti-endotoxic activity of murine monoclonal antibody (E5) assessed by inhibition of priming of human phagocytes by endotoxin
    Y Ono
    Second Department of Internal Medicine, Teikyo University School of Medicine
    Kansenshogaku Zasshi 68:346-52. 1994
    ..activity in response to phorbol myristate acetate (PMA) as an index of the priming effect of lipopolysaccharide (LPS) on the release of reactive oxygen species...
  94. pmc Interactions of constitutive nitric oxide with PAF and thromboxane on rat intestinal vascular integrity in acute endotoxaemia
    F Laszlo
    Department of Pharmacology, Wellcome Research Laboratories, Beckenham, Kent
    Br J Pharmacol 113:1131-6. 1994
    ..2. Administration of L-NAME (1-10 mg kg-1, s.c.) concurrently with E. coli lipopolysaccharide (LPS; 3 mg kg-1, i.v...
  95. pmc Delayed circulatory failure due to the induction of nitric oxide synthase by lipoteichoic acid from Staphylococcus aureus in anaesthetized rats
    S J De Kimpe
    William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
    Br J Pharmacol 114:1317-23. 1995
    ..05 mg kg-1), an agent which binds endotoxin (lipopolysaccharides, LPS), did not affect the delayed circulatory failure caused by LTA...
  96. ncbi Serum antibody response induced in mice after oral administration of three different antigens of enterotoxigenic Escherichia coli in enteric coated microparticles
    J A Adachi
    Center for Infectious Diseases, University of Texas Houston Medical School and School of Public Health, Houston, Texas, USA
    J Travel Med 7:304-8. 2000
    ..In the same group, an anti-CFA/I response was observed in 6 mice and anti-LPS in 4 mice as determined by Western blot. All mice in group 3 showed > 1:104 anti-CFA/I antibody titer...
  97. pmc Nitric oxide-mediated hyporeactivity to noradrenaline precedes the induction of nitric oxide synthase in endotoxin shock
    C Szabo
    William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
    Br J Pharmacol 108:786-92. 1993
    ..to noradrenaline was investigated in a model of circulatory shock induced by endotoxin (lipopolysaccharide; LPS) in the rat. 2...
  98. pmc Co-induction of nitric oxide synthase and cyclo-oxygenase: interactions between nitric oxide and prostanoids
    T A Swierkosz
    William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
    Br J Pharmacol 114:1335-42. 1995
    1. Lipopolysaccharide (LPS) co-induces nitric oxide synthase (iNOS) and cyclo-oxygenase (COX-2) in J774.2 macrophages. Here we have used LPS-activated J774...
  99. ncbi Cervical root compression monitoring by flexor carpi radialis H-reflex in healthy subjects
    M Sabbahi
    School of Physical Therapy, Texas Woman s University, Houston, USA
    Spine (Phila Pa 1976) 24:137-41. 1999
    ..5 msec; 0.2 pulses per second [pps] at H-max), whereas the flexor carpi radialis muscle H-reflex was recorded by electromyography...
  100. ncbi Effect of a moderate intensity exercise training protocol on the metabolism of macrophages and lymphocytes of tumour-bearing rats
    R F Bacurau
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, , , Brazil
    Cell Biochem Funct 18:249-58. 2000
    ..2 per cent) and in the presence of LPS (45.0 per cent)...
  101. pmc Selective inhibition by dexamethasone of induction of NO synthase, but not of induction of L-arginine transport, in activated murine macrophage J774 cells
    A R Baydoun
    Vascular Biology Research Centre, King s College, London
    Br J Pharmacol 110:1401-6. 1993
    ..Effects of dexamethasone on induction of nitric oxide (NO) synthase and L-arginine transport by lipopolysaccharide (LPS) were examined in a murine cultured macrophage cell line J774...

Research Grants99

  1. Pathogenic Mechanisms of Shiga Toxins
    Vernon L Tesh; Fiscal Year: 2010
    ..Thus, the innate immune response elicited by bacterial products such as Stxs or lipopolysaccharides (LPS) may contribute to vascular damage...
  2. CELLULAR ACTIVATION MECHANISMS IN SEPTIC SHOCK
    Peter S Tobias; Fiscal Year: 2012
    ..induced by conserved and often integral structural components of microbes, such as the lipopolysaccharides (LPS) of Gram-negative bacteria...
  3. Identification of age-related mediators of pro-inflammatory signaling
    AMANDA OPALUCH; Fiscal Year: 2010
    ..One of these receptors, TLR4, recognizes lipopolysaccharide (LPS) present on cell walls of gram-negative bacteria...
  4. Seena Ajit; Fiscal Year: 2014
    ..Using exosomes secreted by THP-1 cells stimulated with lipopolysaccharides (LPS) and exosomes purified from patient blood samples, we will measure the alterations in miRNAs including hsa-miR-939 ..
  5. Mechanisms of abnormal enterochromaffin cell secretion in Crohn's disease
    Mark S Kidd; Fiscal Year: 2012
    ..Cytokines (particularly IL1[unreadable]) and bacterial lipopolysaccharides (LPS) and muramyl dipeptide (MDP) have been implicated in Crohn's pathogenesis through activation of TOLL4 receptor ..
  6. Novel approaches to attenuate lipopolysaccharide-induced inflammation
    Ramesh K Ganju; Fiscal Year: 2012
    ..Furthermore, we have shown that Slit2 inhibits lipopolysaccharides (LPS)-induced changes in proteins that promote vascular stability in endothelial cells...
  7. Thomas Y Ma; Fiscal Year: 2015
    ..Our preliminary studies indicated that lipopolysaccharide (LPS) at physiologically relevant concentrations (...
  8. Geert Jan Boons; Fiscal Year: 2014
    ..We propose to develop such approaches for the synthesis of libraries of lipopolysaccharides (LPS), glycosylphosphatidylinositol (GPI) anchors and chondroitin sulfates (CS), and employ the resulting compounds to ..
  9. David S Pasco; Fiscal Year: 2014
    ..Our hypothesis is that endophytic bacteria within E. purpurea are a major source of LPS and Brawn type lipoproteins and variation in the amount/type of these endophytes are responsible for differences in ..
  10. Keiko Watanabe; Fiscal Year: 2015
    ..Since certain bacterial lipopolysaccharides (LPS) from periodontal lesions and free fatty acids (FFAs) from HF diet promote inflammation through Toll-like-receptor ..
  11. Preclinical development of DS-96, a novel alkylpolyamine endotoxin squestrant
    SUNIL ABRAHAM DAVID; Fiscal Year: 2012
    ..ill patients, is a consequence of the overwhelming innate immune response to endotoxins, or lipopolysaccharides (LPS), present on the surface of Gram-negative bacteria (including Category A and B Select Agents)...
  12. BIOCHEMICAL PARAMETERS OF LPS-INITIATED HOST RESPONSE
    David Morrison; Fiscal Year: 1990
    The multiple physiological, pathological and immunological activities of bacterial endotoxins (lipopolysaccharides, LPS) have been well documented...
  13. Jian Li; Fiscal Year: 2016
    ..Our approach, based upon modeling the interaction between polymyxins and the lipid A of lipopolysaccharides (LPS), is novel...
  14. PAUL MICHIEL WEERS; Fiscal Year: 2016
    ..In that role, apolipoproteins have the ability to bind and neutralize lipopolysaccharides (LPS), which are abundantly present in the outer membrane of Gram-negative bacteria...
  15. BIOSYNTHESIS AND FUNCTION OF LIPOPOLYSACCHARIDES
    Pei Zhou; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The lipid A moiety of lipopolysaccharide (LPS) forms the outer monolayer of the outer membrane of most Gram-negative bacteria...
  16. TLR-mediated Signaling Complex Formation and Regulation of Effector Functions
    Hans Haecker; Fiscal Year: 2012
    ..Ten TLRs are known in humans that specifically recognize diverse pathogen constituents such as lipopolysaccharides (LPS), peptidoglycans (PGN), nucleotides and proteins...
  17. Jennifer S Brodbelt; Fiscal Year: 2016
    ..the development of advanced mass spectrometric approaches for characterization of the complex lipopolysaccharides (LPS), including the endotoxic lipid A sub-unit, that comprise the key constituents of the outer membrane of Gram-..
  18. Role of SR-BI in LPS detoxification
    Xiang An Li; Fiscal Year: 2012
    ..We recently report a novel and potentially clinically important function of SR-BI in protection against LPS-induced death...
  19. A novel Anti-endotoxin Peptide for Septic Shock
    Xiao Jia Chang; Fiscal Year: 2010
    ..for this Phase-I study is to validate CN16 as therapeutic candidate for the prevention of septic shock mediated by LPS in vitro and in vivo using two sepsis models in mice...
  20. INTERACTION OF LIPOPOLYSACCHARIDES WITH SERUM PROTEINS
    STANLEY VUKAJLOVICH; Fiscal Year: 1991
    Endotoxic lipopolysaccharides (LPS), by virtue of their functional localization on the outer membrane of gram negative bacteria, play a pivotal role in the interaction of the bacterium with host defenses...
  21. THE STRESS-ACTIVATED PROTEIN KINASE PATHWAY
    John M Kyriakis; Fiscal Year: 2010
    ..moieties, produced by microbial pathogens, which trigger innate immune responses): bacterial lipopolysaccharide (LPS), peptidoglycan (PGN) and flagellin (FliC)...
  22. Resolution and repair of acute lung injury by macrophage-derived iNOS
    FRANCO R D'ALESSIO; Fiscal Year: 2011
    ..t. LPS) and assessed the response at intervals out to day 10, a time when injury had resolved...
  23. Franco R D'Alessio; Fiscal Year: 2014
    ..t. LPS) and assessed the response at intervals out to day 10, a time when injury had resolved...
  24. Cyclic AMP, Cytokine Modulation and Alcoholic Liver Disease
    Craig J McClain; Fiscal Year: 2013
    ..Previous studies from our group evaluated the role of SAM in positively modulating endotoxin (LPS)-stimulated TNF and IL-10 production related to ALD...
  25. IL-1?? as a mediator of maternal infection-induced effects on offspring neuroinfl
    Heping Zhou; Fiscal Year: 2010
    ..Our laboratory has found that maternal exposure to lipopolysaccharide (LPS), a major component of Gram-negative bacteria cell wall, attenuated the mRNA expression of cytokines, namely tumor ..
  26. Astar Winoto; Fiscal Year: 2016
    ..in T-cell receptor stimulated T cells from T-cell specific-FADD knockout (tFADD-/-) mice, in lipopolysaccharide (LPS) stimulated dendritic cells (DCs) from DC-specific-FADD deficient (dcFADD-/-) mice and in LPS stimulated ..
  27. Joel A Swanson; Fiscal Year: 2016
    ..Activation of macrophages by lipopolysaccharide (LPS) and cytokines such as interferon-? (IFN?) and tumor necrosis factor-[unreadable] (TNF[unreadable]) increases their ..
  28. PP2A Regulation of the JNK MAPK Pathway
    Thomas P Shanley; Fiscal Year: 2012
    ..A canonical pathway examined in both states of dysregulation is LPS induction of tumor necrosis factor (TNF)-1 which is dependent on transcriptional and post-transcriptional ..
  29. Lung Toxicity of Carbon Nanotubes in Models of Pre-Existing Respiratory Disease
    JAMES CHRISTOPHER BONNER; Fiscal Year: 2010
    ..of allergic asthma in mice and increase pulmonary fibrosis in mice pre-exposed to bacterial lipopolysaccharide (LPS)...
  30. Haichao Wang; Fiscal Year: 2016
    ..by gene knockout) or activities (by using neutralizing antibodies, HDL, or peptide antagonists) will affect LPS-, TSST-1-, IFN-?-, or SAA-induced HMGB1 release in wild-type, and SAA- or SAA receptor (e.g...
  31. A role for IL-1 in SJIA monocyte phenotypes: A RAPPORT ancillary study
    Elizabeth D Mellins; Fiscal Year: 2013
    ..We also observe reduced interferon signaling in SJIA monocytes and increased LPS-stimulated IL-1[unreadable] secretion...
  32. KLF2 as a novel regular for monocyte activation and function
    Hiranmoy Das; Fiscal Year: 2012
    ..Furthermore, forced overexpression of KLF2 in monocytes inhibits the LPS-mediated induction of proinflammatory factors, cytokines and chemokines and reduced phagocytosis...
  33. Ronald G Collman; Fiscal Year: 2015
    ..data in vitro, show that statins downregulate M/M activation patterns implicated in HAND pathogenesis, including LPS-induced CD16 &CD163 upregulation, migration to MCP- 1, and MCP-1 production by M/M as well as astrocytes...
  34. Resolving Biomaterial Inflammatory Response by Controlling Macrophage Phenotype
    James D Bryers; Fiscal Year: 2010
    ..be generated in vitro by activation of monocyte-derived cells using interferon-3 (IFN-3) and lipopoly- saccharide (LPS), while M2 cells can be generated by activation with interleukin-4 (IL-4)...
  35. Negative regulation of NF-kB and inflammation by TAX1BP1
    Edward W Harhaj; Fiscal Year: 2012
    ..such as tumor necrosis factor (TNF) or interleukin-1 (IL-1), and bacterial products such as lipopolysaccharide (LPS) is normally transient due to the upregulation of multiple negative feedback inhibitors, including IkBa and A20 (..
  36. Stefanie N Vogel; Fiscal Year: 2014
    ..Toll-like receptor (TLR) signaling induced by conserved microbial structures, such as bacterial lipopolysaccharide (LPS) or Respiratory Syncytial Virus (RSV) fusion (F) protein, and cell-derived cytokines, such as interferons (IFNs), ..
  37. Aldose Reductase: A Regulator of Inflammatory Signals
    KOTA VENKATA RAMANA; Fiscal Year: 2011
    ..Also, AR inhibition attenuates lipopolysaccharide (LPS)-induced secretion of cytokines such as TNF-alpha, IL-6, and IL-10, secondary messenger cAMP and prostaglandin E2 ..
  38. Samithamby Jeyaseelan; Fiscal Year: 2016
    ..pneumoniae LPS challenge. Our key findings support a critical yet unrecognized function for NLRP6 during Klebsiella infection...
  39. DAVID CARL ZAWIEJA; Fiscal Year: 2015
    ..peptides and hormones, suggesting that the primary trafficking of dietary endotoxins, such as, lipopolysaccharide (LPS) is via lymphatics...
  40. Histone deacetylase 7 and its interacting proteins in endothelial cells
    Hung Ying Kao; Fiscal Year: 2013
    ..response to cytokine stimulation such as tumor necrosis factor alpha (TNF1), interleukin (IL), lipopolysaccharide (LPS), or interferons (IFNs)...
  41. Suppression of vascular endothelial cell inflammation
    Xiao Feng Yang; Fiscal Year: 2013
    ..In response to the stimulation of bacterial lipopolysaccharide (LPS), mouse aortic ECs (MAECs) from atherogenic apolipoprotein E-deficient ApoE-/- mice express higher levels of pro-IL-..
  42. Control of Drug Delivery to the CNS: Modulating P-glycoprotein Activity
    William A Banks; Fiscal Year: 2013
    ..P-gp at the brain endothelial cell is inhibited by lipopolysaccharide (LPS) and tumor necrosis factor alpha (TNF)...
  43. Lipoic Acid Therapy for Experimental Autoimmune Encephalomyelitis
    DENNIS NEIL BOURDETTE; Fiscal Year: 2013
    ..For Specific Aim 1, microglia cultured from mouse brains will be activated using either lipopolysaccharide (LPS) or the cytokines tumor necrosis factor-alpha (TNF-1) and interferon-gamma (IFN-3) in the presence or absence of ..
  44. Laura E Nagy; Fiscal Year: 2014
    ..Activation of macrophages by endotoxin/ lipopolysaccharide (LPS), a component of the cell wall of gram-negative bacteria, via the toll-like receptor 4 (TLR-4) leads to the ..
  45. Mark W Hall; Fiscal Year: 2015
    ..pro-inflammatory cytokine tumor necrosis factor (TNF)-1 upon ex vivo stimulation with bacterial lipopolysaccharide (LPS) and reduced monocyte HLA-DR expression...
  46. ETHANOL REGULATION OF KUPFFER CELL SIGNAL TRANSDUCTION
    Laura Nagy; Fiscal Year: 2009
    ..Activation of macrophages by endotoxin/ lipopolysaccharide (LPS), a component of the cell wall of gram-negative bacteria, via the toll-like receptor 4 (TLR-4) leads to the ..
  47. Anthony R Means; Fiscal Year: 2015
    ..of CaMKK2 from macrophages results in markedly attenuated response to the bacterial endotoxin, Lipopolysaccharide (LPS) that binds to and activates Toll-like receptor 4 (TLR4) and causes systemic inflammation...
  48. Claire Larmonier; Fiscal Year: 2014
    ..as reduced immune tissue infiltration in various model of inflammation including, streptomycin induced diabetes, LPS induced septic shock, ischemia and reperfusion injury...
  49. Regulation of IFN-beta induction by P2X7 purinergic receptor signaling
    JUDITH ANNE SMITH; Fiscal Year: 2011
    ..g. IL-1[unreadable]) by macrophages stimulated with endotoxin (LPS)...
  50. Lipocalin 2 in Inflammation and Metabolic Control
    Xiaoli Chen; Fiscal Year: 2012
    ..NF-(B and C/EBP binding sites and glucocorticoid response element;and LCN2 secretion is highly regulated by LPS and TNF(...
  51. The Role of Beta-Arrestins 1 and 2 in Rheumatoid Arthritis
    Hongkuan Fan; Fiscal Year: 2010
    ..It was also demonstrated that LPS- and the endogenous TLR4 ligand low molecular weight hyaluronan (LMW-HA)- induced TNF, IL-6 and IL-10 production ..
  52. TNF and Mitochondrial Dysfunction in ALD
    Craig J McClain; Fiscal Year: 2010
    ..We postulate that chronic alcohol abusecauses increased gut permeability and endotoxemia(increased LPS), depletionof critical antioxidants (e.g...
  53. Role of the Aryl Hydrocarbon Receptor in Lung Inflammation
    PATRICIA JANET SIME; Fiscal Year: 2012
    ..Importantly, AhR expression also limits inflammation after LPS exposure, a stimulus that does not signal through the AhR...
  54. Ekihiro Seki; Fiscal Year: 2014
    ..alcoholic intake increases intestinal permeability that leads to an elevation of endotoxin (lipopolysaccharide, LPS) levels in the portal vein...
  55. Francis Young In Lee; Fiscal Year: 2016
    ..demonstrated inhibition of osteoclastogenesis in vitro in osteoclast-precursor macrophages and inhibition of LPS-induced osteolysis in vivo. rhCRG inhibited NFATc1 among several osteoclastogenic transcription factors...
  56. A role for miRNAs in adenosine-dependent alternative macrophage activation
    Samuel Joseph Leibovich; Fiscal Year: 2013
    ..M1 activation is mediated by IFNg and/or TLR agonists such as LPS, while M2 activation is broadly defined as mediated by IL4 or IL13 through the common IL4Ra...
  57. HMGB1 and neutrophil efferocytosis.
    JAROSLAW WALDEMAR ZMIJEWSKI; Fiscal Year: 2012
    ..associated with or not associated with HMGB1;2) To examine the role of HMGB1 binding co-factors, including IL-12, LPS, TNF-1, and bacterial DNA, in modulating the ability of HMGB1 to affect phagocytosis of apoptotic neutrophils and ..
  58. Pro-inflammatory glucocorticoid effects in the CNS
    Robert M Sapolsky; Fiscal Year: 2010
    ..In all experiments, intact rats will be exposed to either LPS, a bacteria-derived molecule which stimulates a robust inflammatory response, or a seizure-inducing excitotoxin, ..
  59. miR-155 regulation of cellular susceptibility to HIV-1 infection
    JULIO MARTIN-GARCIA; Fiscal Year: 2013
    ..b>LPS and poly(I:C) (TLR4 and TLR3 ligands, respectively), have been shown to inhibit HIV-1 replication in and infection ..
  60. Role of Fetal Lung Macrophages in Bronchopulmonary Dysplasia
    Lawrence S Prince; Fiscal Year: 2013
    ..in macrophages prevents alterations in lung morphogenesis induced by Gram negative bacterial lipopolysaccharide (LPS)...
  61. Adenosine, Toll-Like Receptors and Angiogenesis
    Samuel Joseph Leibovich; Fiscal Year: 2011
    ..Whether increased responsiveness of LPS-treated macrophages to A2AR activation is due to increased levels of A2ARs or to increased responsiveness of A2ARs ..
  62. Involvement of ADAM17 in LPS-induced lung inflammation
    Bruce K Walcheck; Fiscal Year: 2010
    ..airway mucosal surface to components of the cell wall of Gram-negative bacteria, in particular, lipopolysaccharide (LPS)...
  63. Novel TIRF microscopy analyzing trafficking & signaling at the cell cortex
    Derek Toomre; Fiscal Year: 2009
    ..Consistent with the recovery act's goal, this funding will provide full-time summer employment for 4 undergraduate students and accelerate scientific achievement of the parent DP2 award...
  64. Gram-Negative Sepsis: Pharmacophore-Based Therapeutics
    Sunil David; Fiscal Year: 2007
    ..The pathogenesis of Gram-negative septic shock is due to the host response to endotoxins, or lipopolysaccharides (LPS), present on the surface of gram-negative bacteria...
  65. Genetics and biosynthesis of an O antigen essential for symbiosis
    KENNETH D NOEL; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The lipopolysaccharides (LPS) of Gram-negative bacteria have complex structures and multiple functions...
  66. RHIZOBIAL LIPOPOLYSACCHARIDES ESSENTIAL FOR INFECTION
    Russell W Carlson; Fiscal Year: 2010
    ..and acetylation changes to the O-chain polysaccharide and an overall change in the hydrophobicity of the LPS and the whole rhizobial cell occur during symbiosis. Our Specific Aims are: (1...
  67. Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of Periodontitis
    JUSTIN RODNEY SAVAGE; Fiscal Year: 2011
    ..tissues through a subgingival microbial biofilm on the tooth surface that releases bacterial lipopolysaccharide (LPS) and other antigens...
  68. Seth M Weinberg; Fiscal Year: 2016
    ..of the multiplex CL/P families;(3) identifying candidate genes for the endophenotypes (BMP4 for OO defects and IRF6 for lip print whorls), (4) performing other genetic analyses of CL/P and the endophenotypes...
  69. The Role of IRF6 During Craniofacial Development
    Steven L Goudy; Fiscal Year: 2012
    ..Genetic variation in Interferon Regulatory Factor 6 (IRF6) causes Van der Woude syndrome (VWS) and contributes 12% risk of isolated cleft lip and palate...
  70. MOLECULAR GENETIC EPIDEMIOLOGY OF CLEFT LIP AND PALATE
    Jeffrey C Murray; Fiscal Year: 2013
    ..We will look at the IRF6, BMP4, TFAP2A and FOXE1 genotypes for the role of genotype in predicting wound healing response, an especially ripe ..
  71. EMILY YIN CHU; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Interferon regulatory factor 6 (IRF6) variants are associated with common isolated forms of cleft lip with or without clefting of the palate (CLP), as well as with dominantly inherited forms of CLP...
  72. JUSTIN RODNEY SAVAGE; Fiscal Year: 2015
    ..First, it decreases IL-1[unreadable]- and P. gingivalis lipopolysaccharide (LPS)-stimulated IL-1[unreadable], prostaglandin E2, and matrix metalloproteinases (MMP) 1, 2, 3, and 9 release from ..
  73. Regulation of TLR4 Signaling in Enterocytes in Necrotizing Enterocolitis
    Amin Afrazi; Fiscal Year: 2013
    ..death from gastrointestinal disease in preterm infants, characterized by mucosal disruption and lipopolysaccharide (LPS) translocation across the inflamed intestine...
  74. Maria Lauda Tomasi; Fiscal Year: 2016
    ..Finally, we found that lipopolysaccharide (LPS) and Ubc9 RNAi treatment alone increased expression of proinflammatory cytokines in RAW cells (macrophage cell line)..
  75. Bioengineering of Novel Synthetic Lipid-Peptide Lung Surfactants
    Robert H Notter; Fiscal Year: 2013
    ..premature infants with NRDS;(ii) mice with ALI/ARDS in vivo from intratracheal instillation of lipopolysaccharide (LPS);(3) rabbits with ALI/ARDS in vivo from severe hyperoxic-exposure;and (4) ventilated rabbits with surfactant-..
  76. Brent E Palmer; Fiscal Year: 2016
    ..from HIV-1-infected smokers and nonsmokers secrete increased amounts of IL-10 in response to lipopolysaccharide (LPS) compared to uninfected individuals and that cigarette smoke exposure reduced LPS-induced TNF-alpha secretion from ..
  77. ERIC PETER SCHMIDT; Fiscal Year: 2015
    ..The dose-response and time course of lipopolysaccharide (LPS, a model of sepsis) induced pulmonary glycocalyx degradation will be determined...
  78. Opioid Impact on Trim37-Induced Restriction of HIV
    LAUREN BRITTANY BEACH; Fiscal Year: 2013
    ..for morphine's drug-induced effects, can be induced by the toll-like receptor 4 ligand, lipopolysaccharide (LPS)...
  79. NADPH OXIDASE REGULATION OF THE MACROPHAGE INFLAMMATORY PHENOTYPE IN SEPSIS
    John W Christman; Fiscal Year: 2013
    ..bone marrow in wt mice resulted in enhanced NF-[unreadable]B activation and neutrophilic inflammation in lungs LPS challenge...
  80. Helen E Raybould; Fiscal Year: 2016
    ..an inflammatory state and diet-induced obesity is associated with low chronic plasma level of lipopolysaccharide (LPS), a breakdown product of the cell wall of Gram-negative bacteria...
  81. David B Peden; Fiscal Year: 2016
    ..inflammation and acute increases in neutrophilic inflammation in allergic asthmatics (AAs) associated with LPS and O3 challenge...
  82. DOUGLAS BUCHANAN MCCREERY; Fiscal Year: 2016
    ..we will evaluate the safety of 140 hours of microstimulation in the cat cochlear nucleus at a pulse rate of 500 pps, in order to determine the roles of stimulus pulse rate and stimulus charge density in stimulation-induced neuronal ..
  83. Louis B Justement; Fiscal Year: 2014
    ..fusion protein attenuates recruitment of neutrophils to the lung in response to intratracheal administration of LPS. Thus, TLT2 serves an important, non-redundant role in regulating the innate immune response...
  84. Zhanxiang Zhou; Fiscal Year: 2014
    ..The most well-known mechanism underlying organ-organ interactions is gut-generated endotoxin (lipopolysaccharide, LPS) signal...
  85. Validation in Transgenic Animal Models of Clinical Correlates of IC/PBS
    Yi Luo; Fiscal Year: 2013
    ..The two models represent two distinct pathogenic pathways (LPS-induced vs...
  86. TGF-beta1 and Mitochondrial Dysfunction in LPS-Induced Renal Failure
    L Jay Stallons; Fiscal Year: 2013
    ..We recently examined renal and mitochondrial function over time in a lipopolysaccharide (LPS) model of sepsis in mice. Glomerular filtration was normal at 18 h but decreased (i.e...
  87. Kun Ping Lu; Fiscal Year: 2015
    ..phenotypes induced by IL-33 [or OVA challenge], and potently inhibited cytokine production induced by HDM or LPS in vitro and/or in mice...
  88. SHIVALINGAPPA KOTTUR SWAMYNATHAN; Fiscal Year: 2016
    ..when the cornea is first exposed to the environment, (ii) abrogated within 24h of bacterial lipopolysaccharide (LPS) injection or Herpes Simplex Virus type-1 (HSV-1) infection concurrent with neutrophil infiltration, (iii) ..
  89. Bi-functional Therapeutics for Allergy-BFTA
    Swey Shen Chen; Fiscal Year: 2010
    ..Herein, we propose a pan-IgE therapeutics (PIT) based on recent laboratory observation in that the receptor-binding CH(2 and CH(3 linker loop (C(2-3L) of human ..
  90. Role of Interferon Regulatory Factor 6 (Irf6) in cutaneous wound healing
    Martine Dunnwald; Fiscal Year: 2010
    ..One potential factor is Interferon Regulatory Factor 6 (IRF6). Previously, IRF6 was shown to be essential for the development of the lip and palate in humans...
  91. CLONING AND CHARACTERIZATION OF THE VAN DER WOUDE GENE
    Brian Schutte; Fiscal Year: 2009
    ..Mutations in Interferon Regulatory Factor 6 (IRF6) cause Van der Woude syndrome...
  92. CHARACTERIZATION OF THE LPS RECEPTOR FOR ACUTE PHASE
    Sanna Goyert; Fiscal Year: 2002
    ..Since lipopolysaccharide (LPS, endotoxin), a component of the outer membrane of Gram-negative bacteria which is thought to be the major bacterial ..
  93. INTERFERON Y MEDIATES ANTI E COLI DEFENSES AND SEPSIS
    Alan Cross; Fiscal Year: 2001
    ..Since bacterial lipopolysaccharide (LPS) is considered an important initiator of sepsis, clinical trials have been conducted with agents designed to ..
  94. RELATIONSHIPS BETWEEN PROSTANOIDS AND CELLULAR INJURY
    John Flynn; Fiscal Year: 2000
    ..especially those of the microcirculation (MEC), are a prime target for circulating bacterial lipopolysaccharide (LPS)...
  95. TRAUMA & ORGAN FAILURE--ROLE OF LPS BINDING PROTEIN
    Stewart Wang; Fiscal Year: 2000
    ..During gram-negative sepsis, endotoxins (LPS) binds to CD14 receptors on mononuclear cells, causing release of inflammatory mediators which can cause tissue ..
  96. LPS and Monocyte Activation in HIV Neuropathogenesis
    Dana Gabuzda; Fiscal Year: 2009
    ..by applicant): A recent study (Nature Med 2006;12:1365) showed that elevated circulating lipopolysaccharide (LPS), a consequence of microbial translocation from a leaky gut, is a cause of systemic immune activation in chronic ..
  97. P. gingivalis lipid A species modulation of endothelial cell gene activation prog
    Richard Darveau; Fiscal Year: 2007
    ..gingivalis, a periopathogen, alters its LPS lipid A composition in response to the hemin concentration in the growth medium. We have obtained P...
  98. NOVEL PATHWAYS OF ENDOTOXIN SIGNALING
    Matthew Fenton; Fiscal Year: 2001
    ..Stimulation of macrophages by gram-negative bacterial lipopolysaccharide (LPS) is responsible for initiating some of the cellular responses that lead to septic shock...
  99. PIT-1T AND THYROTROPIN BETA SUBUNIT GENE EXPRESSION
    BRYAN HAUGEN; Fiscal Year: 1999
    ..To date, only one pituitary-specific gene transcription factor has been discovered, called Pit-1/GHF1...