IRF4

Summary

Gene Symbol: IRF4
Description: interferon regulatory factor 4
Alias: LSIRF, MUM1, NF-EM5, SHEP8, interferon regulatory factor 4, lymphocyte-specific interferon regulatory factor, multiple myeloma oncogene 1
Species: human

Top Publications

  1. pmc Prolonged early G(1) arrest by selective CDK4/CDK6 inhibition sensitizes myeloma cells to cytotoxic killing through cell cycle-coupled loss of IRF4
    Xiangao Huang
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065, USA
    Blood 120:1095-106. 2012
  2. pmc Frequent expression of multiple myeloma 1/interferon regulatory factor 4 in Burkitt lymphoma
    Gabriela Gualco
    Consultoria em Patologia, Botucatu, Sao Paulo18602 010, Brazil
    Hum Pathol 40:565-71. 2009
  3. ncbi B-cell transcription factors Pax-5, Oct-2, BOB.1, Bcl-6, and MUM1 are useful markers for the diagnosis of nodular lymphocyte predominant Hodgkin lymphoma
    Rosemarie Herbeck
    Department of Pathology, Emergency County Hospital, Timisoara, Romania
    Rom J Morphol Embryol 52:69-74. 2011
  4. pmc Distinct roles of transforming growth factor-beta-activated kinase 1 (TAK1)-c-Rel and interferon regulatory factor 4 (IRF4) pathways in human T cell lymphotropic virus 1-transformed T helper 17 cells producing interleukin-9
    Alaa Refaat
    Division of Pathogenic Biochemistry, Institute of Natural Medicine, University of Toyama, Toyama 930 0194, Japan
    J Biol Chem 286:21092-9. 2011
  5. pmc Human T cell lymphotropic virus 1 manipulates interferon regulatory signals by controlling the TAK1-IRF3 and IRF4 pathways
    Shunsuke Suzuki
    Division of Pathogenic Biochemistry, Institute of Natural Medicine, University of Toyama, Toyama 930 0194, Japan
    J Biol Chem 285:4441-6. 2010
  6. ncbi SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1
    S Rao
    Department of Pathology, The University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 274:11115-24. 1999
  7. pmc A novel interferon regulatory factor family transcription factor, ICSAT/Pip/LSIRF, that negatively regulates the activity of interferon-regulated genes
    T Yamagata
    Third Department of Internal Medicine, Tokyo University, Japan
    Mol Cell Biol 16:1283-94. 1996
  8. ncbi Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma
    S Iida
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Nat Genet 17:226-30. 1997
  9. pmc Assembly requirements of PU.1-Pip (IRF-4) activator complexes: inhibiting function in vivo using fused dimers
    A L Brass
    Howard Hughes Medical Institute, The University of Chicago, 5841 S Maryland Avenue, MC1028, Chicago IL 60637, USA
    EMBO J 18:977-91. 1999
  10. pmc Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4
    S Gupta
    Department of Medicine, Columbia University, New York, New York 10032, USA
    J Exp Med 190:1837-48. 1999

Research Grants

  1. FAIM in Immunity and Autoimmunity
    THOMAS ROTHSTEIN; Fiscal Year: 2009
  2. Thomas L Rothstein; Fiscal Year: 2014
  3. Sex Differences and Estrogen Receptors Regulate Dendritic Cells in Inflammation
    Susan Kovats; Fiscal Year: 2010
  4. Bonnie B Blomberg; Fiscal Year: 2014
  5. Regulation of conventional versus innate CD8+ T cell development
    Leslie J Berg; Fiscal Year: 2013
  6. Ulf Klein; Fiscal Year: 2014
  7. Modulation of Apoptosis by IRF-4 in EBV transformation
    Luwen Zhang; Fiscal Year: 2010
  8. Alessandra B Pernis; Fiscal Year: 2016
  9. Evan D Rosen; Fiscal Year: 2016
  10. Yui Hsi Wang; Fiscal Year: 2014

Detail Information

Publications228 found, 100 shown here

  1. pmc Prolonged early G(1) arrest by selective CDK4/CDK6 inhibition sensitizes myeloma cells to cytotoxic killing through cell cycle-coupled loss of IRF4
    Xiangao Huang
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065, USA
    Blood 120:1095-106. 2012
    ..Consequently, the IRF4 protein required to protect myeloma cells from apoptosis is markedly reduced in pG1 and further in pG1-S in ..
  2. pmc Frequent expression of multiple myeloma 1/interferon regulatory factor 4 in Burkitt lymphoma
    Gabriela Gualco
    Consultoria em Patologia, Botucatu, Sao Paulo18602 010, Brazil
    Hum Pathol 40:565-71. 2009
    ..5%) with multiple myeloma 1 nuclear expression, suggesting a late germinal center stage of differentiation...
  3. ncbi B-cell transcription factors Pax-5, Oct-2, BOB.1, Bcl-6, and MUM1 are useful markers for the diagnosis of nodular lymphocyte predominant Hodgkin lymphoma
    Rosemarie Herbeck
    Department of Pathology, Emergency County Hospital, Timisoara, Romania
    Rom J Morphol Embryol 52:69-74. 2011
    ..1/OBF.1, Bcl-6 protein and multiple myeloma-1/interferon regulatory factor-4 (MUM1/IRF-4) may aid in clarifying the diagnosis...
  4. pmc Distinct roles of transforming growth factor-beta-activated kinase 1 (TAK1)-c-Rel and interferon regulatory factor 4 (IRF4) pathways in human T cell lymphotropic virus 1-transformed T helper 17 cells producing interleukin-9
    Alaa Refaat
    Division of Pathogenic Biochemistry, Institute of Natural Medicine, University of Toyama, Toyama 930 0194, Japan
    J Biol Chem 286:21092-9. 2011
    ..b>Interferon regulatory factor 4 (IRF4), a transcription factor overexpressed in all HTLV-1-infected cells, regulated IL-17 and IL-9 ..
  5. pmc Human T cell lymphotropic virus 1 manipulates interferon regulatory signals by controlling the TAK1-IRF3 and IRF4 pathways
    Shunsuke Suzuki
    Division of Pathogenic Biochemistry, Institute of Natural Medicine, University of Toyama, Toyama 930 0194, Japan
    J Biol Chem 285:4441-6. 2010
    ..On the other hand, IRF4, another member in the IRF family of transcription factors overexpressed in a Tax-independent manner, negatively ..
  6. ncbi SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1
    S Rao
    Department of Pathology, The University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 274:11115-24. 1999
    ..1 and harbors different transactivation domains. We conclude that SPI-B may activate unique target genes in B lymphocytes and interact with unique, although currently unidentified, cofactors...
  7. pmc A novel interferon regulatory factor family transcription factor, ICSAT/Pip/LSIRF, that negatively regulates the activity of interferon-regulated genes
    T Yamagata
    Third Department of Internal Medicine, Tokyo University, Japan
    Mol Cell Biol 16:1283-94. 1996
    ..leukemia cell line or activated T cells (ICSAT); this protein is the human homolog of the recently cloned Pip/LSIRF. ICSAT is structurally most closely related to the previously cloned ICSBP, a member of the IFN regulatory factor (..
  8. ncbi Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma
    S Iida
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Nat Genet 17:226-30. 1997
    ..The translocation juxtaposes the immunoglobulin heavy-chain (IgH) locus to MUM1 (multiple myeloma oncogene 1)/IRF4 gene, a member of the interferon regulatory factor (IRF) family known to be active in the control ..
  9. pmc Assembly requirements of PU.1-Pip (IRF-4) activator complexes: inhibiting function in vivo using fused dimers
    A L Brass
    Howard Hughes Medical Institute, The University of Chicago, 5841 S Maryland Avenue, MC1028, Chicago IL 60637, USA
    EMBO J 18:977-91. 1999
    ..1 and Pip from one regulated by PU.1 alone. This strategy should prove generally useful in analyzing the function of interacting transcription factors in vivo, and for identifying novel genes regulated by such complexes...
  10. pmc Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4
    S Gupta
    Department of Medicine, Columbia University, New York, New York 10032, USA
    J Exp Med 190:1837-48. 1999
    ..Since expression of IRF-4 is mostly confined to lymphoid cells, these data provide a potential mechanism by which IL-4-inducible genes can be regulated in a lineage-specific manner...
  11. ncbi Posttranslational regulation of IRF-4 activity by the immunophilin FKBP52
    Y Mamane
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research and Department of Microbiology, McGill University, Montreal, Canada
    Immunity 12:129-40. 2000
    ..IRF-4-FKBP52 association inhibited IRF4-PU.1 binding to the immunoglobulin light chain enhancer E(lambda2-4) as well as IRF-4-PU...
  12. ncbi Stage-specific modulation of IFN-regulatory factor 4 function by Krüppel-type zinc finger proteins
    S Gupta
    Department of Medicine, Columbia University, New York, NY 10032, USA
    J Immunol 166:6104-11. 2001
    ..These findings thus support a model whereby IRF-4 function is modulated in a stage-specific manner by its interaction with developmentally restricted sets of Krüppel-type zinc finger proteins...
  13. ncbi IRF-4 activities in HTLV-I-induced T cell leukemogenesis
    Yael Mamane
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, and Department of Microbiology and Immunology, McGill University, Montreal, Canada
    J Interferon Cytokine Res 22:135-43. 2002
    ..Further investigation of these novel IRF-4-regulated genes will permit a mechanistic understanding of IRF-4 function in HTLV-I-induced leukemogenesis...
  14. pmc Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression
    Jyothi Rengarajan
    Department of Immunology and Infectious Disease, Harvard School of Public Health, Boston, MA 02115, USA
    J Exp Med 195:1003-12. 2002
    ..In particular, NFATs are important regulators of inducible IL-4 gene expression. Interferon regulatory factor 4 (IRF4) is an immune system-restricted interferon regulatory factor that is required for lymphocyte ..
  15. ncbi Regulation of IFN regulatory factor 4 expression in human T cell leukemia virus-I-transformed T cells
    Sonia Sharma
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Canada
    J Immunol 169:3120-30. 2002
    ..These experiments constitute the first detailed analysis of human IRF-4 transcriptional regulation within the context of HTLV-I infection and transformation of CD4(+) T lymphocytes...
  16. ncbi Modulation of T cell cytokine production by interferon regulatory factor-4
    Chuan Min Hu
    Department of Medicine, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    J Biol Chem 277:49238-46. 2002
    ..These studies thus support the notion that IRF-4 represents one of the lymphoid-specific components that control the ability of T lymphocytes to produce a distinctive array of cytokines...
  17. ncbi Expression of the B-cell proliferation marker MUM1 by melanocytic lesions and comparison with S100, gp100 (HMB45), and MelanA
    Uma Sundram
    Department of Pathology, Stanford University Medical Center, Stanford, California 94305, USA
    Mod Pathol 16:802-10. 2003
    ..Previous work has demonstrated that the B-cell proliferation/differentiation marker MUM1/IRF4 is detected in malignant melanoma and hematolymphoid malignancies, but not in any other neoplasm tested (including ..
  18. ncbi IRF-4 expression in the human myeloid lineage: up-regulation during dendritic cell differentiation and inhibition by 1alpha,25-dihydroxyvitamin D3
    Maria Cristina Gauzzi
    Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
    J Leukoc Biol 77:944-7. 2005
    ..These results point to IRF-4 as a potential player in human myeloid DC differentiation and as a novel target for the immunomodulatory activity of 1,25(OH)(2)D(3)...
  19. pmc Negative regulation of Toll-like-receptor signaling by IRF-4
    Hideo Negishi
    Department of Immunology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 102:15989-94. 2005
    ..induction of proinflammatory cytokines is markedly enhanced in peritoneal macrophages from mice deficient in the Irf4 gene, whereas the induction is inhibited by the ectopic expression of IRF-4 in a macrophage cell line...
  20. ncbi Differential expression of IFN regulatory factor 4 gene in human monocyte-derived dendritic cells and macrophages
    Anne Lehtonen
    Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland
    J Immunol 175:6570-9. 2005
    ..The results show that the expression of IRF4 mRNA, but not of other IRFs, was specifically up-regulated during DC differentiation...
  21. ncbi Genetic determinants of hair, eye and skin pigmentation in Europeans
    Patrick Sulem
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 39:1443-52. 2007
    ..3 is associated with freckles. The fifth region provided refinements to a previously reported association in OCA2, and the sixth encompasses previously described variants in MC1R...
  22. pmc Interferon regulatory factor 4 is involved in Epstein-Barr virus-mediated transformation of human B lymphocytes
    Dongsheng Xu
    Nebraska Center for Virology, School of Biological Sciences, University of Nebraska, Lincoln, Nebraska 68588, USA
    J Virol 82:6251-8. 2008
    ..EBV latent membrane protein 1 (LMP-1) is required for EBV transformation processes. Interferon regulatory factor 4 (IRF-4) is a transcription factor and has oncogenic potential...
  23. pmc A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation
    Jiali Han
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 4:e1000074. 2008
    ..An initial analysis of 528,173 single nucleotide polymorphisms (SNPs) genotyped on 2,287 women identified IRF4 and SLC24A4 as loci highly associated with hair color, along with three other regions encompassing known ..
  24. doi A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia
    Maria Chiara Di Bernardo
    Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK
    Nat Genet 40:1204-10. 2008
    ..36 x 10(-10)), 2q37.1 (rs13397985, SP140; P = 5.40 x 10(-10)), 6p25.3 (rs872071, IRF4; P = 1.91 x 10(-20)), 11q24.1 (rs735665; P = 3.78 x 10(-12)), 15q23 (rs7176508; P = 4.54 x 10(-12)) and 19q13...
  25. pmc Recurrent translocations involving the IRF4 oncogene locus in peripheral T-cell lymphomas
    A L Feldman
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Leukemia 23:574-80. 2009
    ..we identified recurrent translocations involving the multiple myeloma oncogene-1/interferon regulatory factor-4 (IRF4) locus in PTCLs...
  26. pmc Differentiation stage-specific expression of microRNAs in B lymphocytes and diffuse large B-cell lymphomas
    Raquel Malumbres
    Department of Medicine, Division of Hematology Oncology and Molecular and Cellular Pharmacology, Sylvester Comprehensive Cancer Center, University of Miami, FL 33136, USA
    Blood 113:3754-64. 2009
    ..may be physiologically relevant by demonstrating that GC-enriched hsa-miR-125b down-regulates the expression of IRF4 and PRDM1/BLIMP1, and memory B cell-enriched hsa-miR-223 down-regulates the expression of LMO2...
  27. pmc Genome-wide association study of tanning phenotype in a population of European ancestry
    Hongmei Nan
    Channing Laboratory, Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Invest Dermatol 129:2250-7. 2009
    ..genome-wide significance level are located in or adjacent to the loci previously known as pigmentation genes: MATP, IRF4, TYR, OCA2, and MC1R...
  28. pmc Multiple pigmentation gene polymorphisms account for a substantial proportion of risk of cutaneous malignant melanoma
    David L Duffy
    Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
    J Invest Dermatol 130:520-8. 2010
    ..homolog (mouse) gene), TYR (tyrosinase), TYRP1 (tyrosinase-related protein 1), MC1R, OCA2, IRF4 (interferon regulatory factor 4), SLC24A4 (solute carrier family 24, member 4), and SLC45A2 (solute carrier family 45, member 2)) for ..
  29. doi IRF4 polymorphism rs872071 and risk of Hodgkin lymphoma
    Peter Broderick
    Section of Cancer Genetics, Institute of Cancer Research, Royal Marsden Hospitals NHS Trust, London, UK
    Br J Haematol 148:413-5. 2010
    ..We have recently shown that the IRF4 variant rs872071 influences CLL risk...
  30. doi An intronic polymorphism of IRF4 gene influences gene transcription in vitro and shows a risk association with childhood acute lymphoblastic leukemia in males
    Thuy N Do
    Genomic Immunoepidemiology Laboratory, HUMIGEN LLC, The Institute for Genetic Immunology, 2439 Kuser Road, Hamilton, NJ 08690 3303, USA
    Biochim Biophys Acta 1802:292-300. 2010
    ..b>IRF4 is involved in the differentiation of B and T cells and is overexpressed in B-cell malignancies as a result of c-..
  31. doi Verification that common variation at 2q37.1, 6p25.3, 11q24.1, 15q23, and 19q13.32 influences chronic lymphocytic leukaemia risk
    Dalemari Crowther-Swanepoel
    Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK
    Br J Haematol 150:473-9. 2010
    ..CLL risk increased with increasing numbers of risk alleles (P(trend) = 1.40 x 10(-15)), consistent with a polygenic model of disease susceptibility. These data validate the relationship between common variation and risk of CLL...
  32. pmc IRF4 variants have age-specific effects on nevus count and predispose to melanoma
    David L Duffy
    Queensland Institute of Medical Research, Brisbane 4029, Australia
    Am J Hum Genet 87:6-16. 2010
    ..A GWAS of nevus count in Australian adolescent twins identified an association of nevus count with the interferon regulatory factor 4 gene (IRF4 [p = 6 x 10(-9)])...
  33. doi Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells
    Valérie Staudt
    Institute for Immunology, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany
    Immunity 33:192-202. 2010
    Interferon-regulatory factor 4 (IRF4) is essential for the development of T helper 2 (Th2) and Th17 cells...
  34. pmc Genetic susceptibility for chronic lymphocytic leukemia among Chinese in Hong Kong
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7240, USA
    Eur J Haematol 85:492-5. 2010
    ..The rs872071 variant (Odds Ratio (95% Confidence Interval) = 1.78 (1.25-2.53), P = 0.0013) in the IRF4 gene region showed the strongest association, similar to that reported in the UK study...
  35. pmc A germline variant in the interferon regulatory factor 4 gene as a novel skin cancer risk locus
    Jiali Han
    Clinical Research Program, Department of Dermatology, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, USA
    Cancer Res 71:1533-9. 2011
    ..Along with two known pigmentation loci, MC1R and OCA2, the IRF4 rs12203592 T allele was associated with an increased risk of each type of skin cancer (P value, 6...
  36. pmc Interferon regulatory factor 4 (IRF-4) targets IRF-5 to regulate Epstein-Barr virus transformation
    Dongsheng Xu
    School of Biological Sciences, University of Nebraska, Lincoln, Nebraska 68588, USA
    J Biol Chem 286:18261-7. 2011
    ..This work provides insight on how IRFs interact with one another to participate in viral pathogenesis and transformation...
  37. doi Translocations activating IRF4 identify a subtype of germinal center-derived B-cell lymphoma affecting predominantly children and young adults
    Itziar Salaverria
    Institute of Human Genetics, University Hospital Schleswig Holstein Campus Kiel Christian Albrechts University Kiel, Kiel, Germany
    Blood 118:139-47. 2011
    ..Those were predominantly GCB-type DLBCL or follicular lymphoma grade 3, shared strong expression of IRF4/MUM1 and BCL6, and lacked PRDM1/BLIMP1 expression and t(14;18)/BCL2 breaks. BCL6 aberrations were common...
  38. pmc Oncogenic IRFs provide a survival advantage for Epstein-Barr virus- or human T-cell leukemia virus type 1-transformed cells through induction of BIC expression
    Ling Wang
    Division of Hematology Oncology, Viral Oncology Program, Sylvester Comprehensive Cancer Center, Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    J Virol 85:8328-37. 2011
    ..Two oncogenic IRFs, IRF4 and -7, in addition to some other members of the family, bind to and significantly transactivate the Bic promoter...
  39. pmc Shared and distinct functions of the transcription factors IRF4 and IRF8 in myeloid cell development
    Michio Yamamoto
    Department of Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    PLoS ONE 6:e25812. 2011
    Interferon regulatory factor (IRF) 8 and IRF4 are structurally-related, hematopoietic cell-specific transcription factors that cooperatively regulate the differentiation of dendritic cells and B cells...
  40. pmc Exploiting synthetic lethality for the therapy of ABC diffuse large B cell lymphoma
    Yibin Yang
    Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cancer Cell 21:723-37. 2012
    ..In a cereblon-dependent fashion, lenalidomide downregulates IRF4 and SPIB, transcription factors that together prevent IFNβ production by repressing IRF7 and amplify prosurvival ..
  41. pmc Genetic variants in PARP1 (rs3219090) and IRF4 (rs12203592) genes associated with melanoma susceptibility in a Spanish population
    Maria Peña-Chilet
    Health Research Institute INCLIVA, Valencia, Spain
    BMC Cancer 13:160. 2013
    ..In this case-control study, we try to validate in our population nine melanoma associated markers selected from published GWAS in melanoma predisposition...
  42. pmc Interferon regulatory factor 4 is activated through c-Src-mediated tyrosine phosphorylation in virus-transformed cells
    Ling Wang
    Viral Oncology Program, Division of Hematology Oncology, Sylvester Comprehensive Cancer Center, Miami, Florida, USA
    J Virol 87:9672-9. 2013
    The importance of the oncogenic transcription factor interferon regulatory factor 4 (IRF4) in hematological malignancies has been increasingly recognized...
  43. pmc A polymorphism in IRF4 affects human pigmentation through a tyrosinase-dependent MITF/TFAP2A pathway
    Christian Praetorius
    Department of Biochemistry and Molecular Biology, Biomedical Center, Faculty of Medicine, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland
    Cell 155:1022-33. 2013
    ..A SNP within an intron of the gene encoding Interferon Regulatory Factor 4 (IRF4), a transcription factor with no known role in melanocyte biology, is strongly associated with ..
  44. pmc IRF4 is a key thermogenic transcriptional partner of PGC-1α
    Xingxing Kong
    Division of Endocrinology, Beth Israel Deaconess Medical Center and Department of Genetics, Harvard Medical School, Boston, MA 02215, USA
    Cell 158:69-83. 2014
    ..Here, we identify interferon regulatory factor 4 (IRF4) as a dominant transcriptional effector of thermogenesis...
  45. ncbi Differential expression and distinct functions of IFN regulatory factor 4 and IFN consensus sequence binding protein in macrophages
    S Marecki
    Pulmonary Center, Department of Pathology, Boston University School of Medicine, MA 02118, USA
    J Immunol 163:2713-22. 1999
    IFN regulatory factor 4 (IRF4) and IFN consensus sequence binding protein (ICSBP) are highly homologous members of the growing family of IRF proteins...
  46. ncbi Crystallization and characterization of PU.1/IRF-4/DNA ternary complex
    Carlos R Escalante
    Structural Biology Program, Department of Physiology and Biophysics, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    J Struct Biol 139:55-9. 2002
    ....
  47. ncbi E47, IRF-4, and PU.1 synergize to induce B-cell-specific activation of the class II transactivator promoter III (CIITA-PIII)
    Nienke van der Stoep
    Division of Molecular Biology, Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, E3 Q, PO Box 9600, 2300 RC Leiden, The Netherlands
    Blood 104:2849-57. 2004
    ..The finding that PU.1, IRF-4, and E47 play an important role in the B-cell-mediated activation of CIITA-PIII provides a link between antigen presentation functions and activation and differentiation events in B lymphocytes...
  48. ncbi Polymorphisms in IRF-1 associated with resistance to HIV-1 infection in highly exposed uninfected Kenyan sex workers
    Terry Blake Ball
    Department of Medical Microbiology and Infectious Diseases, University of Manitoba, 730 William Avenue, Winnipeg, Manitoba, Canada
    AIDS 21:1091-101. 2007
    ..To determine the correlation between polymorphisms in the IL-4 gene cluster and resistance to HIV-1 infection...
  49. doi MUM1/IRF4 expression in the circulating compartment of chronic lymphocytic leukemia
    Fiona Craig
    Division of Hematopathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Leuk Lymphoma 49:273-80. 2008
    MUM1/IRF4 is normally expressed in late germinal center/post germinal center B-cells...
  50. doi IRF4 gene rearrangements define a subgroup of CD30-positive cutaneous T-cell lymphoma: a study of 54 cases
    Anne Pham-Ledard
    Department of Histology and Molecular Pathology of Tumors, University Bordeaux 2, and Department of Dermatology, Hôpital Saint André, Bordeaux, France
    J Invest Dermatol 130:816-25. 2010
    The identification of IFN regulatory factor 4 gene (IRF4) translocation in 8 out of 14 cases of cutaneous anaplastic large cell lymphomas (C-ALCLs) (Leukemia, 2009; 23(3):574-80) prompted us to study IRF4 locus status in different ..
  51. pmc IRF4 mutations in chronic lymphocytic leukemia
    Violaine Havelange
    Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
    Blood 118:2827-9. 2011
    b>Interferon regulatory factor 4 (IRF4) is a member of the interferon regulatory factor family of transcription factors and has been shown to have critical functions at several stages of B-cell development...
  52. pmc Increased expression of IRF4 and ETS1 in CD4+ cells from patients with intermittent allergic rhinitis
    S Bruhn
    The Centre for Individualized Medication, Linkoping University Hospital, Linkoping, Sweden
    Allergy 67:33-40. 2012
    The transcription factor (TF) IRF4 is involved in the regulation of Th1, Th2, Th9, and Th17 cells, and animal studies have indicated an important role in allergy...
  53. ncbi Cloning of human lymphocyte-specific interferon regulatory factor (hLSIRF/hIRF4) and mapping of the gene to 6p23-p25
    A Grossman
    Amgen Institute, Ontario Cancer Institute, Toronto, Canada
    Genomics 37:229-33. 1996
    ..To study the role of LSIRF in human lymphocyte development, we have cloned the complete 5.3-kb cDNA for the human homolog (hLSIRF)...
  54. doi PRDM1 is involved in chemoresistance of T-cell lymphoma and down-regulated by the proteasome inhibitor
    Wei Li Zhao
    State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Shanghai Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, China
    Blood 111:3867-71. 2008
    ..were detected in laser-microdissected T-lymphoma cells in 27 and 14 patients, respectively, mostly in cases with IRF4 expression. PRDM1beta was associated with increased c-MYC expression...
  55. doi [Molecular abnormalities in lymphomas]
    G Delsol
    Universite Paul Sabatier, CHU de Toulouse Purpan, Toulouse, France
    Bull Cancer 97:1347-64. 2010
    ..signature corresponding to germinal center B-cell-like (GCB: CD10+, BCL6 [B-Cell Lymphoma 6]+, centerine+, MUM1-) and a subgroup expressing an activated B-cell-like signature (ABC: CD10-, BCL6-, centerine-, MUM1+)...
  56. ncbi Primary cutaneous marginal zone B-cell lymphoma with amyloid deposition: report of two cases with review of literature
    Hai Yan Zhang
    Department of Pathology, Nanyang Medical School of Henan Province, Nanyang, Henan 473000, PR China
    Chin J Cancer 29:634-40. 2010
    ..This study was to analyze the diagnosis and differential diagnosis of two cases of PCMZL with amyloid deposition...
  57. doi Presence of simian virus 40 in diffuse large B-cell lymphomas in Tunisia correlates with germinal center B-cell immunophenotype, t(14;18) translocation, and P53 accumulation
    Khaled Amara
    Department of Pathology, CHU Farhat Hached, Sousse, Tunisia
    Mod Pathol 21:282-96. 2008
    ..Therefore, we evaluated by immunohistochemistry the expression patterns of CD10, BCL6, MUM1, BCL2, and P53 in 86 diffuse large B-cell lymphomas (48 simian virus 40-positive and 38 simian virus 40-negative ..
  58. pmc Prognostic significance of B-cell differentiation genes encoding proteins in diffuse large B-cell lymphoma and follicular lymphoma grade 3
    Ana Borovecki
    Department of Clinical Pathology and Cytology, Merkur University Hospital, Zajceva 19, 10000 Zagreb, Croatia
    Croat Med J 49:625-35. 2008
    ..To define prognostic significance of B-cell differentiation genes encoding proteins and BCL2 and BCL6 gene abnormalities in diffuse large B-cell lymphoma and follicular lymphoma grade 3 with >75% follicular growth pattern...
  59. ncbi Primary breast diffuse large B-cell lymphoma shows a non-germinal center B-cell phenotype
    Sayaka Yoshida
    Second Department of Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan
    Mod Pathol 18:398-405. 2005
    ..stage IE; 13 cases, stage IIE; two cases) by immunohistochemistry using various markers including CD10, Bcl-6, MUM1 and MIB-1 and by molecular analysis of the immunoglobulin heavy chain gene variable region...
  60. ncbi [Clinicopathologic and immunohistochemical study of intra-abdominal non-Hodgkin B-cell lymphoma occurring in children]
    Wen Ping Yang
    Department of Pathology, Jiangxi Children s Hospital, Nanchang 330006, China
    Zhonghua Bing Li Xue Za Zhi 38:759-64. 2009
    ..To study the clinicopathologic features, immunohistochemical findings, EBV and c-myc gene status of intra-abdominal non-Hodgkin B-cell lymphoma occurring in children...
  61. pmc Specificity of IRF4 translocations for primary cutaneous anaplastic large cell lymphoma: a multicenter study of 204 skin biopsies
    David A Wada
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Mod Pathol 24:596-605. 2011
    ..We previously reported IRF4 (interferon regulatory factor-4) translocations in cutaneous anaplastic large cell lymphomas...
  62. ncbi Pathobiology of primary mediastinal B-cell lymphoma
    Stefano A Pileri
    Institute of Haematology Seragnoli, Bologna University, Policinico S Orsola, Via Massarenti 9, 40138, Bologna, Italy
    Leuk Lymphoma 44:S21-6. 2003
    ..BCL-2 protein is usually expressed but there are few data describing the expression of MUM1/IRF4, PAX5/BSAP, BCL-6, or the B-cell transcription factors BOB.1, Oct-2, and PU.1...
  63. ncbi Incidence of diffuse large B-cell lymphoma of germinal center B-cell origin in whole diffuse large B-cell lymphoma: tissue fluorescence in situ hybridization using t(14;18) compared with immunohistochemistry
    Yuko Hirose
    Department of Hematology and Immunology, Kanazawa Medical University, Ishikawa, Japan
    Int J Hematol 81:48-57. 2005
    ..Fifty-seven cases were subclassified in an immunohistochemical study with anti-CD10, anti-bcl-6, and anti-MUM1 antibodies...
  64. pmc Common gene variants in the tumor necrosis factor (TNF) and TNF receptor superfamilies and NF-kB transcription factors and non-Hodgkin lymphoma risk
    Sophia S Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, United States of America
    PLoS ONE 4:e5360. 2009
    ..We hypothesized that the TNF and NF-kappaB pathways are important for NHL and that gene variations across the pathways may alter NHL risk...
  65. doi Most primary central nervous system diffuse large B-cell lymphomas occurring in immunocompetent individuals belong to the nongerminal center subtype: a retrospective analysis of 31 cases
    Eyas M Hattab
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Mod Pathol 23:235-43. 2010
    ..nongerminal center types based on gene expression profiles and immunohistochemical expression of CD10, Bcl-6, and MUM1. Studies have shown that the overall survival rate of the germinal center group is better than that of the ..
  66. ncbi Immunohistochemical classification of de novo, transformed, and relapsed diffuse large B-cell lymphoma into germinal center B-cell and nongerminal center B-cell subtypes correlates with gene expression profile and patient survival
    Chadwick F Haarer
    Department of Pathology, University of Arizona, Tucson, AZ, USA
    Arch Pathol Lab Med 130:1819-24. 2006
    ..subgroups, including germinal center B-cell (GCB) and activated B-cell subgroups, by using gene expression profiling and, reportedly, immunohistochemistry for CD10, Bcl-6, and multiple myeloma-1/interferon regulatory factor-4 (MUM1/IRF4).
  67. ncbi Commitment of B lymphocytes to a plasma cell fate is associated with Blimp-1 expression in vivo
    C Angelin-Duclos
    Departments of Microbiology and Pathology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Immunol 165:5462-71. 2000
    ..they express germinal center markers peanut agglutinin or CD10 but not Bcl-6, and most express CD138 (syndecan-1), IRF4, and cytoplasmic Ig...
  68. ncbi A monoclonal antibody (MUM1p) detects expression of the MUM1/IRF4 protein in a subset of germinal center B cells, plasma cells, and activated T cells
    B Falini
    Institutes of Hematology and Internal Medicine, University of Perugia, Perugia, Italy
    Blood 95:2084-92. 2000
    A new monoclonal antibody (MUM1p) was used to study the cell/tissue expression of human MUM1/IRF4 protein, the product of the homologous gene involved in the myeloma-associated t(6;14) (p25;q32)...
  69. ncbi [Detection of t (14; 18) translocation and bcl-2 amplification in diffuse large B-cell lymphoma]
    Hui Yong Jiang
    Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
    Zhonghua Bing Li Xue Za Zhi 36:84-9. 2007
    ..To investigate the role of t (14; 18) chromosomal translocation and bcl-2 amplification in classification, clinical staging and prognostic evaluation of diffuse large B cell lymphoma (DLBCL)...
  70. pmc Primary diffuse large B-cell lymphoma of the oral cavity: germinal center classification
    Indraneel Bhattacharyya
    Department of Oral and Maxillofacial Diagnostic Sciences, University of Florida College of Dentistry, Gainesville, FL 32610, USA
    Head Neck Pathol 4:181-91. 2010
    ..IHC was performed using antibodies against germinal center markers (CD10, BCL6), activated B-cell markers (MUM1, BCL2) and Ki-67 (proliferation marker)...
  71. doi Diagnostic and prognostic evaluation of phenotypic markers TRAF1, MUM1, BCL2 and CD15 in cutaneous CD30-positive lymphoproliferative disorders
    M F Benner
    Department of Dermatology, Leiden University Medical Center, PO Box 9600, Leiden 2300 RC, The Netherlands
    Br J Dermatol 161:121-7. 2009
    ..Differentiation between these entities is often not possible on the basis of histology alone, but several markers, including TRAF1, MUM1 and BCL2, have been reported to provide additional diagnostic information.
  72. ncbi [Solitary plasmacytoma of spine: a clinical, radiologic and pathologic study of 13 cases]
    Miao Xia He
    Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
    Zhonghua Bing Li Xue Za Zhi 38:307-11. 2009
    ..To study the clinical, radiologic and pathologic features of solitary plasmacytoma of spine...
  73. doi B-cell non-Hodgkin lymphomas in Uganda: an immunohistochemical appraisal on tissue microarray
    Lynnette K Tumwine
    Department of Pathology, Makerere University Medical School, PO Box 7072, Kampala, Uganda
    Hum Pathol 39:817-23. 2008
    ..In BL, a homogeneous phenotype (CD10(+), Bcl-6(+), Bcl-2(-), MUM1/IRF4-, and Ki-67 approximately 100%) and a stable Epstein-Barr virus integration were found...
  74. ncbi Genetics of pigmentation and melanoma predisposition
    L N Pho
    Department of Dermatology, University of Utah Health Sciences Center, Salt Lake City, UT 84112, USA
    G Ital Dermatol Venereol 145:37-45. 2010
    ..have unveiled single nucleotide polymorphisms (SNPs) or genetic variants in MC1R, TPCN2, ASIP, KITLG, NCKX5, TYR, IRF4, OCA2, and TYRP1 pigmentation genes...
  75. doi Diffuse large B-cell lymphoma of non-germinal center B-cell type of the heart in an immunocompetent woman: an autopsy case
    Tadashi Terada
    Department of Pathology, Shizuoka Municipal Shimizu Hospital, Miyakami 1231, Shimizu ku, Shizuoka 424 8636, Japan
    Med Oncol 28:207-10. 2011
    ..for CD45, CD20, CD79α, bcl-2, and λ-chain, but negative for EBV latent membrane antigen 1, CD10, bcl-6 and MUM1. Epstein-Barr virus protein and DNA were negative by immunohistochemistry and in situ hybridization...
  76. doi 2-Methoxyestradiol induce the conversion of human peripheral blood memory B lymphocytes into plasma cells
    Marie Pierre Cayer
    HEMA QUEBEC, Quebec City, QC, Canada
    J Immunol Methods 355:29-39. 2010
    ..Plasma cells generated by 2ME treatment of normal human B lymphocytes expressed elevated levels of IRF4 and reduced levels of Pax5 and Bcl-6. Similarly, levels of XBP-1 and Blimp-1 transcripts were increased...
  77. ncbi Diffuse large B-cell lymphomas with germinal center B-cell-like differentiation immunophenotypic profile are associated with high apoptotic index, high expression of the proapoptotic proteins bax, bak and bid and low expression of the antiapoptotic protei
    Maria Bai
    Department of Pathology, Medical Faculty, University of Ioannina, Ioannina, Greece
    Mod Pathol 17:847-56. 2004
    ..Therefore, the bcl6/CD10/MUM1/CD138 differentiation immunophenotypic profiles were studied in relation to (a) the apoptotic index, (b) the ..
  78. doi MUM1 expression in cutaneous CD30+ lymphoproliferative disorders: a valuable tool for the distinction between lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma
    W Kempf
    Kempf und Pfaltz, Histologische Diagnostik, Schaffhauserplatz 3, CH 8006 Zurich, Switzerland
    Br J Dermatol 158:1280-7. 2008
    ..MUM1 (Multiple Myeloma oncogene 1) is expressed in systemic ALCL and classical Hodgkin lymphoma...
  79. doi Prognostic impact of activated B-cell focused classification in diffuse large B-cell lymphoma patients treated with R-CHOP
    Heidi Nyman
    Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland
    Mod Pathol 22:1094-101. 2009
    ..The expression of CD10, Bcl-6, MUM1/IRF4, Bcl-2, and FOXP1 was determined immunohistochemically from 88 samples of diffuse large B-cell lymphoma patients ..
  80. ncbi AIDS-related B-cell lymphoma (ARL): correlation of prognosis with differentiation profiles assessed by immunophenotyping
    Christian Hoffmann
    Infectious Diseases Outpatient Clinic, II Department of Medicine, Universitatsklinikum Schleswig Holstein, Campus Kiel, Chemnitzstrasse 33, 24116 Kiel, Germany
    Blood 106:1762-9. 2005
    ..to CD3, CD10, CD20, CD38, CD138/Syndecan-1 (Syn-1), multiple myeloma-1/interferon regulatory factor-4 (MUM1/IRF4), B-cell lymphoma protein-2 (BCL-2), BCL-6, latent membrane protein-1 (LMP-1), and Ki-67...
  81. ncbi Fast, through-bond mediated energy transfer from Ir(III) to Ru(II) in di- and tetranuclear heterometallic assemblies: elucidation of a two-step Ir --> Ir --> Ru energy transfer process
    Cristiana Sabatini
    Istituto per la Sintesi Organica e la Fotoreattivita, Consiglio Nazionale delle Ricerche ISOF CNR, Via P Gobetti 101, 40129, Bologna, Italy
    Photochem Photobiol Sci 6:397-405. 2007
    ..and emission) properties for the mononuclear species Ir(F4), Ir and Ru and for the polymetallic species Ir-Ru and ((IrF4))(2)-Ir-Ru. For Ir-Ru, the Ir --> Ru energy transfer step is exothermic by ca. 0...
  82. doi Clinicopathologic significance of immunophenotypic profiles related to germinal center and activation B-cell differentiation in diffuse large B-cell lymphoma from Chinese patients
    Yan hui Liu
    Department of Pathology and Laboratory Medicine, Guangdong Provincial People s Hospital, Guangzhou 510080, China
    Hum Pathol 39:875-84. 2008
    ..microarray slides composed of 163 de novo DLBCLs from Chinese patients were immunostained for CD20, CD10, Bcl-6, MUM1, CD138, Bcl-2, Ki-67, cyclin D3, geminin, and P27(Kip1)...
  83. doi Hyperactivated STAT3 in ALK-positive diffuse large B-cell lymphoma with clathrin-ALK fusion
    Shuji Momose
    Department of Pathology, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama 350 8550, Japan
    Hum Pathol 40:75-82. 2009
    ..similar morphologic features and immunohistochemical characteristics, that is, positivity for ALK, IgA, CD138, and MUM1; weak positivity for CD30 and CD79a; and negativity for CD20...
  84. ncbi Characterization of two genes encoding leucine-rich repeat-containing proteins in grass carp Ctenopharyngodon idellus
    M X Chang
    State Key Laboratory of Freshwater Ecology and Biotechnology, Chinese Academy of Sciences, Wuhan, 430072, Hubei Province, PR China
    Immunogenetics 56:710-21. 2005
    ..The putative promoter region of GC-GARP was found to contain transcription factor binding sites for GATA-1, IRF4, Oct-1, IRF-7, IRF-1, AP1, GATA-box and NFAT, and the promoter region of GC-LRG for MYC-MAX, MEIS1, ISRE, IK3, ..
  85. doi The expression of MUM1 in cutaneous T-cell lymphoproliferative disorders
    Matthew J Wasco
    Department of Pathology, University of Michigan Medical Center, Ann Arbor, MI 48109 0602, USA
    Hum Pathol 39:557-63. 2008
    b>MUM1 is a member of the interferon regulatory factor family of transcription factors. It is normally expressed in plasma cells, late B cells, and activated T cells, and has been described in several B-cell malignancies...
  86. pmc Loss of HLA-DR expression and immunoblastic morphology predict adverse outcome in diffuse large B-cell lymphoma - analyses of cases from two prospective randomized clinical trials
    Heinz Wolfram Bernd
    Institute of Pathology, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160 D 23538 Lübeck, Germany
    Haematologica 94:1569-80. 2009
    ....
  87. doi Molecular cloning and characterization of interferon regulatory factors 4 and 8 (IRF-4 and IRF-8) in rainbow trout, Oncorhynchus mykiss
    Jason W Holland
    Scottish Fish Immunology Research Centre, Aberdeen University, Aberdeen AB242TZ, Scotland, United Kingdom
    Fish Shellfish Immunol 29:157-66. 2010
    Mammalian interferon regulatory factor (IRF)4 (PIP, LSIRF, and ICSAT) and IRF8 (ICSBP) are known to be critical in regulating a spectrum of functional and developmental processes in lymphomyeloid cell lineages either through direct ..
  88. doi T-cell leukemia 1 expression in nodal Epstein-Barr virus-negative diffuse large B-cell lymphoma and primary mediastinal B-cell lymphoma
    Gabriela Gualco
    Consultoria em Patologia, Botucatu, SP 18602 010, Brazil
    Hum Pathol 41:1238-44. 2010
    ..The cases were analyzed by immunohistochemistry for the expression of TCL1, CD10, BCL-2, BCL-6, and MUM1. We also evaluated c-MYC translocation by fluorescence in situ hybridization...
  89. pmc Nodal diffuse large B-cell lymphomas in children and adolescents: immunohistochemical expression patterns and c-MYC translocation in relation to clinical outcome
    Gabriela Gualco
    Consultoria em Patologia, Botucatu, Sao Paulo, Brazil
    Am J Surg Pathol 33:1815-22. 2009
    ..classification criteria, with application of immunohistochemistry for the detection of CD10, BCL-6, and MUM1 proteins to divide the lymphomas into germinal center and nongerminal center types...
  90. ncbi CD5+ T-cell/histiocyte-rich large B-cell lymphoma
    Chung Che Chang
    Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Mod Pathol 15:1051-7. 2002
    ..The CD5+ neoplastic large B-cells expressed bcl-6 and MUM1/IRF4 but not CD138 by immunohistochemistry...
  91. ncbi Cluster analysis of apoptosis-associated bcl2 family proteins in diffuse large B-cell lymphomas. Relations with the apoptotic index, the proliferation profile and the B-cell differentiation immunophenotypes
    Maria Bai
    Department of Pathology, University of Ioannina, Ioannina, Greece
    Anticancer Res 24:3081-8. 2004
    ..In order to gain further insight into the apoptosis profile of DLBCL, 79 cases were investigated to determine whether distinct clusters of the combined expression levels of bcl2 family proteins can be identified in these lymphomas...
  92. ncbi Evidence of abortive plasma cell differentiation in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma
    Maike Buettner
    Institute for Pathology, Department of Internal Medicine III, Nikolaus Fiebiger Center, Friedrich Alexander University, Erlangen, Germany
    Hematol Oncol 23:127-32. 2005
    ..Pax-5, a transcription factor required for B-lineage commitment, and IRF4/Mum1, which is physiologically expressed in germinal centre cells and plasma cells, were consistently detectable in HRS ..
  93. pmc IFN regulatory factor 4 regulates the expression of a subset of Th2 cytokines
    Ayele Nati N Ahyi
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Walther Cancer Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Immunol 183:1598-606. 2009
    ..When Th2 cells are separated based on levels of IL-10 secretion, IRF4 expression segregates into the subset of Th2 cells expressing high levels of IL-10...
  94. pmc Primary mediastinal B-cell lymphoma: detection of BCL2 gene rearrangements by PCR analysis and FISH
    Cherie H Dunphy
    Divisions of Hematopathology, University of North Carolina, Chapel Hill, NC, USA
    J Hematop 1:77-84. 2008
    ..Of further interest, BCL6 gene mutations and BCL6 and/or MUM1 expression in a number of PMBCLs have supported an activated B-cell (ABC) origin...
  95. doi Diffuse large B-cell lymphoma with a high number of epithelioid histiocytes (lymphoepithelioid B-cell lymphoma): a study of Osaka Lymphoma Study Group
    Naoki Wada
    Department of Pathology, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita Osaka, 565 0871, Japan
    Virchows Arch 455:285-93. 2009
    ..Immunohistochemically, the large lymphoid cells were CD20(+), CD15(-), and CD3(-) and positive for CD10, bcl-6, and MUM1 in nine (41%), eight (36%), and 12 (55%) of 22 cases, respectively...
  96. doi High levels of topoisomerase IIalpha protein expression in diffuse large B-cell lymphoma are associated with high proliferation, germinal center immunophenotype, and response to treatment
    George Pentheroudakis
    Department of Medical Oncology, Ioannina University Hospital, Ioannina, Greece
    Leuk Lymphoma 51:1260-8. 2010
    ..of cell cycle proteins (Ki67, p53, HDM2, p21, p14, pRb, p16, and cyclins A, B1, D1, D2, D3, and E) and BCL6/CD10/MUM1/CD138 B-cell differentiation immunophenotype and outcome...
  97. doi Plasmablastic lymphoma may occur as a high-grade transformation from plasmacytoma
    Xin Qing
    Department of Pathology, Harbor UCLA Medical Center, 1000 West Carson Street, Torrance, CA 90509, USA
    Exp Mol Pathol 90:85-90. 2011
    ..The large tumor cells expressed MUM1, OCT-2 and BOB...
  98. ncbi Identification of rare Epstein-Barr virus infected memory B cells and plasma cells in non-monomorphic post-transplant lymphoproliferative disorders and the signature of viral signaling
    Rita Shaknovich
    Department of Pathology, Columbia University Medical Center, Columbia University, New York, NY 10032, USA
    Haematologica 91:1313-20. 2006
    ....
  99. doi Germinal center B (GCB) and non-GCB cell-like diffuse large B cell lymphomas have similar outcomes following autologous haematopoietic stem cell transplantation
    Luciano J Costa
    Division of Hematology, Mayo Clinic, Rochester, MN 55905, USA
    Br J Haematol 142:404-12. 2008
    ..Immunohistochemical analysis was performed for CD10, BCL-6, MUM1 (allowing classification into GCB and non-GCB-like DLBCL) and BCL-2...
  100. doi [Febrile cellulitis surrounding a scar revealing a large immunoblastic B-cell lymphoma]
    M Charavin-Cocuzza
    Pôle Pluridisciplinaire de Médecine, Service de Dermatologie, CHU Albert Michallon, BP 217, 38043 Grenoble Cedex 09, France
    Ann Dermatol Venereol 135:848-51. 2008
    ..We report the first case of a pericicatricial skin infiltration, mimicking febrile dermohypodermitis, revealing diffuse immunoblastic large B-cell non-Hodgkin's lymphoma...
  101. doi Overexpression of PAX5 induces apoptosis in multiple myeloma cells
    Maryse Proulx
    HEMA QUEBEC, Quebec, G1V 5C3, QC, Canada
    Int J Hematol 92:451-62. 2010
    ..Expression analysis of specific plasma cell transcription factors (IRF4, Blimp-1 and XBP-1) suggests that PAX5 reexpression does not induce retrodifferentiation of plasma cells into B ..

Research Grants33

  1. FAIM in Immunity and Autoimmunity
    THOMAS ROTHSTEIN; Fiscal Year: 2009
    ..It boosts CD40 signaling by enhancing CD40L-stimulated increases in NF-[unreadable]B and IRF4, and, as a result thereof, it further reduces the CD40L-stimulated decline in BCL-6...
  2. Thomas L Rothstein; Fiscal Year: 2014
    ..It boosts CD40 signaling by enhancing CD40L-stimulated increases in NF-:B and IRF4, and, it enhances the CD40L-stimulated decline in BCL-6...
  3. Sex Differences and Estrogen Receptors Regulate Dendritic Cells in Inflammation
    Susan Kovats; Fiscal Year: 2010
    ..that ER1 signaling in myeloid progenitors induces an elevated amount of the transcription factor interferon regulatory factor 4 (IRF4), which leads to a developmental program underlying CD11b+ DC differentiation...
  4. Bonnie B Blomberg; Fiscal Year: 2014
    ..b>IRF4, also known to be important for CSR, will also be measured...
  5. Regulation of conventional versus innate CD8+ T cell development
    Leslie J Berg; Fiscal Year: 2013
    ..that the single most highly up-regulated transcription factor in WT relative to Itk-deficient CD8+ thymocytes is IRF4;further, our preliminary studies indicate that in the absence of IRF4, nearly all CD8+ T cells also develop into ..
  6. Ulf Klein; Fiscal Year: 2014
    ..proposal aims at elucidating the potential tumor-suppressor function of the transcription factor interferon regulatory factor 4 (IRF4) in B-cell malignancy...
  7. Modulation of Apoptosis by IRF-4 in EBV transformation
    Luwen Zhang; Fiscal Year: 2010
    ..apoptosis in EBV-transformed cells, and restore the IRF-4 expression prevented the growth inhibition of endogenous IRF4-kncokdown cells...
  8. Alessandra B Pernis; Fiscal Year: 2016
    ..In the course of isolating proteins interacting with IRF4, a transcription factor required for the differentiation of TH-17 cells, we cloned a novel GEF that we termed IBP (..
  9. Evan D Rosen; Fiscal Year: 2016
    ..In this application, we focus on one particular IRF, IRF4, which is expressed at high levels in adipocytes and immune cells...
  10. Yui Hsi Wang; Fiscal Year: 2014
    ..The treatment of TH2 memory/effector cells with IL-12 induces a significant up-regulation of IRF4 (interferon regulatory factor 4), a critical factor for the development of TH2 and TH17 immune responses...
  11. KENNETH LYNN WRIGHT; Fiscal Year: 2016
    ..We have also observed that IRF4 and IRF8 are both up-regulated in parallel with PRDM1...
  12. Susan L Slager; Fiscal Year: 2015
    ..3. We also replicated previous GWA findings, including those within the IRF4 gene...
  13. CHARACTERIZATION OF KSHV LANA2
    Yuan Chang; Fiscal Year: 2004
    ..LANA2 has structural similarities to the IRF4 transcriptional factor present in B cells...
  14. MOLECULAR MECHANISMS OF THE IGE ALLERGIC RESPONSE
    Raif Geha; Fiscal Year: 2007
    ..will examine the role of NFAT in CD8 cells and dendritic cell function in the allergic phenotype and the role of IRF4 in cytokine regulation...
  15. Role and Regulation of BLIMP-1 in Myeloid Cells
    Kathryn Calame; Fiscal Year: 2006
    ..Finally, the signals and mechanisms responsible for regulation of Blimp-1 expression in myeloid cells will be studied. ..
  16. B LYMPHOCYTE INDUCED MATURATION PROTEIN
    Kathryn Calame; Fiscal Year: 2007
    ..We will purify Blimp-1-containing repression complexes and identify the components of the complexes. ..
  17. Prognostic Models in Diffuse Large B-Cell Lymphoma
    Izidore S Lossos; Fiscal Year: 2010
    ..Further, establishment of a paraffin-based RNA prognostic model using the new methodology of RNA extraction could serve as a paradigm for other lymphomas and tumors. ..
  18. TRANSCRIPTION OF IMMUNOGLOBULIN HEAVY CHAIN GENES
    Kathryn Calame; Fiscal Year: 2001
    ....
  19. Statistical Genetic Methods for Cancer Gene Studies
    Susan Slager; Fiscal Year: 2006
    ..abstract_text> ..
  20. ANALYSIS OF BIDIRECTIONAL SIGNALING MECHANISMS FOR BTLA AND HVEM IN AUTOIMMUNITY
    Kenneth M Murphy; Fiscal Year: 2010
    ..Importantly, BTLA has recently been reported to be involved in the susceptibility in humans to rheumatoid arthritis. Thus, our proposed studies into this newly identified but poorly understood molecule are particularly timely. ..
  21. Cohort Study of Genetic Susceptibility to Cutaneous Malignant Melanoma
    Jiali Han; Fiscal Year: 2010
    ..This research will contribute to the scientific basis for identifying individuals at high risk for melanoma and providing individualized risk management strategies. ..
  22. A PROSPECTIVE STUDY OF ALASKA NATIVES & AMERICAN INDIANS
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
    ..The AIAN cohort will serve as a resource to enhance research and training activities of AIAN students interested in health research, health education, and general public health. ..
  23. Growth Factors and Colon Cancer
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
    ..This study builds on a unique existing resource to study genetic and environmental associations with colorectal cancer. It will provide insight into colon cancer etiology and therefore avenues to disease prevention. ..
  24. Nucleotide Excision Repair Gene Variants and Skin Cancer
    Jiali Han; Fiscal Year: 2005
    ..abstract_text> ..
  25. Genetic Variants in Immunological Mediator Genes and Skin Cancer Risk
    Jiali Han; Fiscal Year: 2008
    ..This research will contribute to the scientific basis for identifying individuals at high-risk for skin cancer and providing individualized risk management strategies. [unreadable] [unreadable] [unreadable]..
  26. Genetic Variants in Pigmentation Genes and Skin Cancer Risk
    Jiali Han; Fiscal Year: 2008
    ..This research will contribute to the scientific basis for identifying high-risk individuals for skin cancer and providing individualized risk management strategies. [unreadable] [unreadable] [unreadable]..
  27. DIET AND SOMATIC MUTATIONS IN COLON CANCER
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2007
    ..e. p53, K-ras, and microsatellite instability). Differences in colon and rectal tumors will be compared. Additionally data from rectal tumors will be combined with that from colon tumors to define disease pathways. ..
  28. Molecular basis of the requirements for IRF4 and IRF8 in pre-B cell development
    Runqing Lu; Fiscal Year: 2010
    ..Mice lacking immune system specific transcription factors IRF4 and IRF8 (IRF4,8) have a profound defect in pre-B cell development...
  29. Prospective Study of DNA Repair Gene Variants in Breast Cancer
    Jiali Han; Fiscal Year: 2009
    ..This innovative work is essential to advance this field, and it has substantial potential for application to other areas of cancer susceptibility. ..
  30. Cis and Trans acting factors for HHV8 lytic replication
    Gregory Pari; Fiscal Year: 2009
    ....
  31. FOUR-CORNERS BREAST AND ENDOMETRIAL CANCER STUDY
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2003
    ..C-peptide, glycosylated hemoglobin, IGF-1, and IGFBP3 will be evaluated with respect to breast and endometrial cancer in a subset of women. ..
  32. HHV-8 ORIGIN-DEPENDENT DNA REPLICATION
    Gregory Pari; Fiscal Year: 2004
    ..abstract_text> ..