IRF-1

Summary

Gene Symbol: IRF-1
Description: interferon regulatory factor 1
Alias: IRF-1, MAR, interferon regulatory factor 1, interferon regulatory factor 1 isoform +I9, interferon regulatory factor 1 isoform d78, interferon regulatory factor 1 isoform d9,10+, interferon regulatory factor 1 isoform delta4, interferon regulatory factor 1 isoform delta7
Species: human

Top Publications

  1. ncbi Deletion of IRF-1, mapping to chromosome 5q31.1, in human leukemia and preleukemic myelodysplasia
    C L Willman
    University of New Mexico School of Medicine, Department of Pathology, Albuquerque 87131
    Science 259:968-71. 1993
  2. ncbi Functionally inactivating point mutation in the tumor-suppressor IRF-1 gene identified in human gastric cancer
    H Nozawa
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Japan
    Int J Cancer 77:522-7. 1998
  3. pmc The promoter of IL-18 binding protein: activation by an IFN-gamma -induced complex of IFN regulatory factor 1 and CCAAT/enhancer binding protein beta
    Vladimir Hurgin
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 99:16957-62. 2002
  4. ncbi Interferon regulatory factor-1 immunoreactivity in neurons and inflammatory cells following ischemic stroke in rodents and humans
    Mihaela Alexander
    Department of Neurology, University of Minnesota, Minneapolis, MN 55455, USA
    Acta Neuropathol 105:420-4. 2003
  5. pmc Intracellular HIV-1 Tat protein represses constitutive LMP2 transcription increasing proteasome activity by interfering with the binding of IRF-1 to STAT1
    Anna L Remoli
    Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena, 299 Rome 00161, Italy
    Biochem J 396:371-80. 2006
  6. pmc Activation of IL-27 p28 gene transcription by interferon regulatory factor 8 in cooperation with interferon regulatory factor 1
    Jidong Zhang
    Division of Immunobiology, Department of Internal Medicine, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    J Biol Chem 285:21269-81. 2010
  7. pmc IRF-1 is required for full NF-kappaB transcriptional activity at the human immunodeficiency virus type 1 long terminal repeat enhancer
    Marco Sgarbanti
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena, 299, Rome 00161, Italy
    J Virol 82:3632-41. 2008
  8. doi c-Jun N-terminal kinase (JNK1) upregulates XIAP-associated factor 1 (XAF1) through interferon regulatory factor 1 (IRF-1) in gastrointestinal cancer
    Jide Wang
    Department of Digestive Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China
    Carcinogenesis 30:222-9. 2009
  9. doi Types I and II interferons upregulate the costimulatory CD80 molecule in monocytes via interferon regulatory factor-1
    B Bauvois
    INSERM, U872, Paris F 75006, France
    Biochem Pharmacol 78:514-22. 2009
  10. pmc IRF-1 transcriptionally upregulates PUMA, which mediates the mitochondrial apoptotic pathway in IRF-1-induced apoptosis in cancer cells
    J Gao
    Department of Surgery, Union Hospital, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China
    Cell Death Differ 17:699-709. 2010

Research Grants

  1. NEW NUCLEAR MATRIX PROTEIN IN BREAST CANCER GROWTH
    Steffi Oesterreich; Fiscal Year: 2002
  2. INFERRING CHROMOSOME ARCHITECTURE FROM GENOMIC SEQUENCE
    Craig Benham; Fiscal Year: 2002
  3. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
  4. Variation in M. tuberculosis in response to host selection
    Sarah Fortune; Fiscal Year: 2009
  5. Novel TIRF microscopy analyzing trafficking & signaling at the cell cortex
    Derek Toomre; Fiscal Year: 2009
  6. Lionel B Ivashkiv; Fiscal Year: 2016
  7. WILLIAM MAURICE SHAFER; Fiscal Year: 2016
  8. FUNCTION OF MATRIX ATTACHMENT REGIONS IN THE IG LOCI
    ANN FEENEY; Fiscal Year: 2000
  9. TOMASZ K KORDULA; Fiscal Year: 2016
  10. Base unpairing regions and chromatin folding
    Terumi Kohwi Shigematsu; Fiscal Year: 2004

Detail Information

Publications285 found, 100 shown here

  1. ncbi Deletion of IRF-1, mapping to chromosome 5q31.1, in human leukemia and preleukemic myelodysplasia
    C L Willman
    University of New Mexico School of Medicine, Department of Pathology, Albuquerque 87131
    Science 259:968-71. 1993
    ..Inactivating rearrangements of one IRF-1 allele, accompanied by deletion of the second allele, were also identified in one case of acute leukemia. Thus, IRF-1 may be a critically deleted gene in human leukemia and myelodysplasia...
  2. ncbi Functionally inactivating point mutation in the tumor-suppressor IRF-1 gene identified in human gastric cancer
    H Nozawa
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Japan
    Int J Cancer 77:522-7. 1998
    ..These results suggest that the loss of functional IRF-1 is critical for the development of human gastric cancers...
  3. pmc The promoter of IL-18 binding protein: activation by an IFN-gamma -induced complex of IFN regulatory factor 1 and CCAAT/enhancer binding protein beta
    Vladimir Hurgin
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 99:16957-62. 2002
    ..The IRF-1-CEBPbeta complex described here probably plays a fundamental role in regulating additional IFN-gamma-responsive genes...
  4. ncbi Interferon regulatory factor-1 immunoreactivity in neurons and inflammatory cells following ischemic stroke in rodents and humans
    Mihaela Alexander
    Department of Neurology, University of Minnesota, Minneapolis, MN 55455, USA
    Acta Neuropathol 105:420-4. 2003
    ..The neuronal expression of IRF-1, in conjunction with the finding that IRF-1 deletion is beneficial to the post-ischemic brain, suggests that expression of IRF-1-dependent genes in neurons plays a role in ischemic neuronal death...
  5. pmc Intracellular HIV-1 Tat protein represses constitutive LMP2 transcription increasing proteasome activity by interfering with the binding of IRF-1 to STAT1
    Anna L Remoli
    Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena, 299 Rome 00161, Italy
    Biochem J 396:371-80. 2006
    ..These effects of Tat provide another effective mechanism by which HIV-1 affects antigen presentation in the context of the MHC class I complex and may have important implications in the use of Tat for vaccination strategies...
  6. pmc Activation of IL-27 p28 gene transcription by interferon regulatory factor 8 in cooperation with interferon regulatory factor 1
    Jidong Zhang
    Division of Immunobiology, Department of Internal Medicine, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    J Biol Chem 285:21269-81. 2010
    ..This study provides further mechanistic information regarding how signals initiated during innate and adaptive immune responses synergize to yield greater IL-27 production and sustained cellular immunity...
  7. pmc IRF-1 is required for full NF-kappaB transcriptional activity at the human immunodeficiency virus type 1 long terminal repeat enhancer
    Marco Sgarbanti
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena, 299, Rome 00161, Italy
    J Virol 82:3632-41. 2008
    ....
  8. doi c-Jun N-terminal kinase (JNK1) upregulates XIAP-associated factor 1 (XAF1) through interferon regulatory factor 1 (IRF-1) in gastrointestinal cancer
    Jide Wang
    Department of Digestive Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China
    Carcinogenesis 30:222-9. 2009
    ..Intrinsic expression of XAF1 in cancer cell is low. Our purpose is to determine the effect of c-Jun N-terminal kinase 1 (JNK1) on XAF1 expression and the putative mechanism...
  9. doi Types I and II interferons upregulate the costimulatory CD80 molecule in monocytes via interferon regulatory factor-1
    B Bauvois
    INSERM, U872, Paris F 75006, France
    Biochem Pharmacol 78:514-22. 2009
    ....
  10. pmc IRF-1 transcriptionally upregulates PUMA, which mediates the mitochondrial apoptotic pathway in IRF-1-induced apoptosis in cancer cells
    J Gao
    Department of Surgery, Union Hospital, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China
    Cell Death Differ 17:699-709. 2010
    ..Finally, we show that IFN-gamma induces IRF-1-mediated upregulation of PUMA in cancer cells. We conclude that IRF-1 can induce apoptosis by the intrinsic pathway independent of the extrinsic pathway by upregulation of PUMA...
  11. doi GAGE, an antiapoptotic protein binds and modulates the expression of nucleophosmin/B23 and interferon regulatory factor 1
    Rupinder K Kular
    Davee Department of Neurology, Northwestern University, Chicago, Illinois 60610, USA
    J Interferon Cytokine Res 29:645-55. 2009
    ..that GAGE overexpression resulted in down-regulation of a key player of IFN-gamma-signaling pathway, interferon regulatory factor 1 (IRF1), and its target genes caspase-1 and caspase-7...
  12. pmc IFNgamma restores breast cancer sensitivity to fulvestrant by regulating STAT1, IFN regulatory factor 1, NF-kappaB, BCL2 family members, and signaling to caspase-dependent apoptosis
    Yanxia Ning
    Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, DC 20057, USA
    Mol Cancer Ther 9:1274-85. 2010
    ..These observations support the exploration of clinical trials combining antiestrogens and compounds that can induce IRF1, such as IFNgamma, for the treatment of some ER-positive breast cancers...
  13. ncbi IFN regulatory factor-1 is required for the up-regulation of the CD40-NF-kappa B activator 1 axis during airway inflammation
    Zhendong Zhao
    Department of Immunology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Immunol 170:5674-80. 2003
    ..The induced expression of the CD40-Act1 axis by inflammatory cytokines in epithelial cells probably plays an important role in priming these cells for their response to CD40 ligand during airway inflammation...
  14. ncbi Phenyl methimazole inhibits TNF-alpha-induced VCAM-1 expression in an IFN regulatory factor-1-dependent manner and reduces monocytic cell adhesion to endothelial cells
    Nilesh M Dagia
    Department of Chemical Engineering, College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA
    J Immunol 173:2041-9. 2004
    ....
  15. ncbi Interferon-alpha induces TRAIL expression and cell death via an IRF-1-dependent mechanism in human bladder cancer cells
    Angela Papageorgiou
    Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Biol Ther 6:872-9. 2007
    ..Together, our results demonstrate that IFNalpha induces TRAIL expression via a STAT-1/IRF-1-dependent mechanism in human bladder cancer cells, and this induction of TRAIL plays an important role in IFNalpha-induced cell killing...
  16. pmc Human papillomavirus type 16 E5 protein induces expression of beta interferon through interferon regulatory factor 1 in human keratinocytes
    Valentina Muto
    Institute of Microbiology, University of Catanzaro Magna Graecia, Catanzaro, Italy
    J Virol 85:5070-80. 2011
    ..This stimulation is specifically mediated by the induction of interferon regulatory factor 1 (IRF-1) which, in turn, induces transcriptional activation of IRF-1-targeted interferon-stimulated ..
  17. doi Dual effects of HTLV-1 bZIP factor in suppression of interferon regulatory factor 1
    Risa Mukai
    Faculty of Pharmaceutical Science at Kagawa Campus, Tokushima Bunri University, 1314 1 Shido, Sanuki, Kagawa 769 2193, Japan
    Biochem Biophys Res Commun 409:328-32. 2011
    ..In addition, IRF-1-mediated apoptosis is significantly reduced by ectopic production of the HBZ. These results suggested that HBZ has dual suppressive effects on IRF-1 function, which may contribute to HTLV-1 related pathogenesis...
  18. doi BRG1 is indispensable for IFN-γ-induced TRIM22 expression, which is dependent on the recruitment of IRF-1
    Yaxin Wang
    Institute for Immunobiology, Department of Immunology, Shanghai Medical College of Fudan University, Shanghai 200032, PR China
    Biochem Biophys Res Commun 410:549-54. 2011
    ....
  19. doi Chronic IFN-γ production in mice induces anemia by reducing erythrocyte life span and inhibiting erythropoiesis through an IRF-1/PU.1 axis
    Sten F Libregts
    Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Blood 118:2578-88. 2011
    ..Notably, down-regulation of either IRF-1 or PU.1 expression is sufficient to overcome IFN-γ-induced inhibition of erythropoiesis. These findings reveal a molecular mechanism by which chronic exposure to IFN-γ induces anemia...
  20. pmc Functional analysis of human herpesvirus 8-encoded viral interferon regulatory factor 1 and its association with cellular interferon regulatory factors and p300
    L Burysek
    Oncology Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    J Virol 73:7334-42. 1999
    ..The ORF K9, viral IRF 1 (vIRF-1), has been cloned, and it was shown that, when overexpressed, it down modulates the interferon-mediated ..
  21. ncbi IFN regulatory factor-2 cooperates with STAT1 to regulate transporter associated with antigen processing-1 promoter activity
    Marie Christine Rouyez
    Department of Hematology, Institut Cochin, Paris, France
    J Immunol 174:3948-58. 2005
    ..Overall, our data indicate that TPO and IFN-gamma activate the expression of TAP1 via a new mechanism that involves functional cooperation between STAT1 and IRF-2 on the TAP1 promoter...
  22. pmc Frequent loss of heterozygosity at the interferon regulatory factor-1 gene locus in breast cancer
    Luciane R Cavalli
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, DC 20057, USA
    Breast Cancer Res Treat 121:227-31. 2010
    ..00; P = 0.003; n = 273 cases) and risk of death (OR = 4.18; P = 0.004; n = 191 cases). Our findings strongly imply a tumor suppressor role for the IRF1 gene in breast cancer...
  23. pmc Intracellular activation of interferon regulatory factor-1 by nanobodies to the multifunctional (Mf1) domain
    Angeli Möller
    Cell Signalling Unit, University of Edinburgh Cancer Research UK Centre, Crewe Road South, Edinburgh EH4 2XR, Scotland, United Kingdom
    J Biol Chem 285:38348-61. 2010
    ..In addition, the data highlight a route for activation of downstream genes in the IRF-1 tumor suppressor pathway using biologics...
  24. pmc Physiological and receptor-selective retinoids modulate interferon gamma signaling by increasing the expression, nuclear localization, and functional activity of interferon regulatory factor-1
    Xin M Luo
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Biol Chem 280:36228-36. 2005
    ..These results suggest that atRA, an RARalpha ligand, regulates IFNgamma-induced IRF-1 by affecting multiple components of the IFNgamma signaling pathway, from the plasma membrane to the nuclear transcription factors...
  25. pmc HIV infection of dendritic cells subverts the IFN induction pathway via IRF-1 and inhibits type 1 IFN production
    Andrew N Harman
    Centre for Virus Research, Westmead Millennium Institute, Westmead, Australia
    Blood 118:298-308. 2011
    ....
  26. ncbi Association of interferon regulatory factor-1, nucleophosmin, nuclear factor-kappaB, and cyclic AMP response element binding with acquired resistance to Faslodex (ICI 182,780)
    Zhiping Gu
    Vincent T Lombardi Cancer Center and Department of Oncology, Georgetown University School of Medicine, Washington, DC 20007, USA
    Cancer Res 62:3428-37. 2002
    ..Thus, some breast cancer cells may survive antiestrogen treatment by bypassing specific growth inhibitory signals induced by antagonist-occupied estrogen receptors...
  27. ncbi Interferon regulatory factor-1 (IRF-1) exhibits tumor suppressor activities in breast cancer associated with caspase activation and induction of apoptosis
    Kerrie B Bouker
    Lombardi Comprehensive Cancer Center and Department of Oncology, Georgetown University School of Medicine, 3970 Reservoir Road NW, Washington, DC 20057, USA
    Carcinogenesis 26:1527-35. 2005
    ..03). These data establish a functional role for IRF-1 in the growth suppression of breast cancer cells and strongly implicate IRF-1 as a tumor suppressor gene in breast cancer that acts, independent of p53, to control apoptosis...
  28. ncbi IFN-gamma/IRF-1-induced p27kip1 down-regulates telomerase activity and human telomerase reverse transcriptase expression in human cervical cancer
    Seung Hoon Lee
    Molecular Therapy Research Center, School of Medicine, Sungkyunkwan University, Samsung Medical Center Annex 8F, 50 Ilwon Dong, Kangnam Ku, Seoul 135 710, Korea
    FEBS Lett 579:1027-33. 2005
    ..In conclusion, we propose that inhibition of the hTERT expression and telomerase activity may be a novel tumor suppressor function of p27...
  29. doi Human rhinovirus-induced epithelial production of CXCL10 is dependent upon IFN regulatory factor-1
    Raza S Zaheer
    Airway Inflammation Group, Institute of Infection, Immunity and Inflammation, and Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada
    Am J Respir Cell Mol Biol 43:413-21. 2010
    ..We conclude that HRV-16-induced CXCL10 production is dependent upon IRF-1, and that the MEK1 pathway-dependent suppression of CXCL10 expression is also mediated via effects on IRF-1...
  30. ncbi Stimulation of interferon regulatory factor-1 by prolactin
    L Yu-Lee
    Department of Medicine, Cell and Molecular Biology Program, Baylor College of Medicine, Houston, Texas 77030, USA
    Lupus 10:691-9. 2001
    ..These findings have much broader implications not only for T lymphocytes but also for other PRL responsive target cells and tissues...
  31. ncbi Gene-gene and gene-environmental interactions of p53, p21, and IRF-1 polymorphisms in Korean women with cervix cancer
    J E Lee
    DNA Link, College of Medicine, Catholic University, Seoul, Korea
    Int J Gynecol Cancer 14:118-25. 2004
    ..The aim of this study was to identify gene-gene and gene-environmental factors affecting cervix carcinogenesis in Korean women...
  32. ncbi Genetic polymorphism of interferon-gamma, interferon-gamma receptor, and interferon regulatory factor-1 genes in patients with hepatitis B virus infection
    Jae Youn Cheong
    Department of Gastroenterology, Genomic Research Center for Gastroenterology, Ajou University School of Medicine, San 5 Wonchon Dong, Youngtong ku, Suwon, South Korea
    Biochem Genet 44:246-55. 2006
    ....
  33. ncbi Interferon regulatory factor-1 regulates reconstituted extracellular matrix (rECM)-mediated apoptosis in human mammary epithelial cells
    M L Bowie
    Department of Medicine, Duke University, Durham, NC 27710, USA
    Oncogene 26:2017-26. 2007
    ..These observations demonstrate that IRF-1 promotes rECM-mediated apoptosis and provide evidence that both rECM and rapid Tam signaling transcriptionally activate IRF-1 through recruitment of CBP to the IRF-1 GAS promoter complex...
  34. pmc Elevated level of SUMOylated IRF-1 in tumor cells interferes with IRF-1-mediated apoptosis
    Junsoo Park
    Molecular Therapy Research Center, Sungkyunkwan University, Seoul 135 710, Korea
    Proc Natl Acad Sci U S A 104:17028-33. 2007
    ..These data support a mechanism whereby SUMOylation of IRF-1 inactivates its tumor suppressor function, which facilitates resistance to the immune response...
  35. pmc Smad7 protein induces interferon regulatory factor 1-dependent transcriptional activation of caspase 8 to restore tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis
    Suntaek Hong
    Department of Molecular Medicine, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, 406 840, Republic of Korea
    J Biol Chem 288:3560-70. 2013
    ..Smad7 was able to activate the caspase 8 promoter through recruitment of the interferon regulatory factor 1 (IRF1) transcription factor to the interferon-stimulated response element (ISRE) site...
  36. ncbi The A4396G polymorphism in interferon regulatory factor 1 is frequently expressed in breast cancer cell lines
    Kerrie B Bouker
    Lombardi Comprehensive Cancer Center and Department of Oncology, Georgetown University School of Medicine, Washington, DC 20057, USA
    Cancer Genet Cytogenet 175:61-4. 2007
    ..We have recently shown that interferon regulatory factor 1 (IRF1) is a putative tumor suppressor gene in breast cancer...
  37. doi Role of the IRF-1 enhancer domain in signalling polyubiquitination and degradation
    Emmanuelle Pion
    CRUK Interferon and Cell Signalling Group, Cell Signalling Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH42XR, UK
    Cell Signal 21:1479-87. 2009
    ....
  38. doi Disease progression from chronic hepatitis C to cirrhosis and hepatocellular carcinoma is associated with repression of interferon regulatory factor-1
    Abdel Rahman N Zekri
    Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt
    Eur J Gastroenterol Hepatol 22:450-6. 2010
    ..This study has been performed to show the expression profile of IRF-1, IRF-3, and IRF-7 in Egyptian patients with HCV-related liver diseases and hepatocellular carcinoma (HCC)...
  39. doi Inhibition of IFN regulatory factor-1 down-regulate Th1 cell function in patients with acute coronary syndrome
    Min Guo
    Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Clin Immunol 30:241-52. 2010
    ..The study was undertaken to investigate the potential effect of IRF-1 on the Th1 cell function in patients with ACS in vitro...
  40. doi Functional relevance of the IRF-1 promoter polymorphism rs2549009 on transcriptional activity in a native genomic environment
    Jasmin Mertens
    Department of Gastroenterology and Endocrinology, University Medical Center Goettingen, Georg August Universitaet, Robert Koch Strasse 40, Goettingen, Germany
    Hum Mol Genet 19:4587-94. 2010
    ..These results provide evidence for a bidirectional IRF-1 gene expression imbalance that appears not to be solely controlled by rs2549009 in cis and may rely on a yet unidentified variant or haplotype or on environmental control in trans...
  41. pmc A multiprotein binding interface in an intrinsically disordered region of the tumor suppressor protein interferon regulatory factor-1
    Vikram Narayan
    CRUK Interferon and Cell Signalling Group, Cell Signalling Unit, Edinburgh Cancer Research UK Centre, University of Edinburgh, Edinburgh EH4 2XR, United Kingdom
    J Biol Chem 286:14291-303. 2011
    ..Interestingly, although NPM1, TRIM28, and YB-1 all bind to the Mf2 domain, they have differing amino acid specificities, demonstrating the degree of combinatorial diversity and specificity available through linear interaction motifs...
  42. doi IRF-1 signaling in central nervous system glial cells regulates inflammatory demyelination
    Zhihua Ren
    Rush University Medical Center, Department of Neurological Sciences, Multiple Sclerosis Center, 1725 W Harrison Street, Suite 309, Chicago, IL 60612, United States
    J Neuroimmunol 233:147-59. 2011
    The present study provides evidence that interferon regulatory factor 1 (IRF-1) signaling in glial cells is involved in the pathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE)...
  43. ncbi The detection of IRF-1 promoter polymorphisms and their possible contribution to T helper 1 response in chronic hepatitis C
    Hidetsugu Saito
    Department of Internal Medicine, School of Medicine, Keio University, Shinjuku ku, Tokyo 160 8582, Japan
    J Interferon Cytokine Res 22:693-700. 2002
    ..These results suggest that the IRF-1 promoter SNP types are positively involved in Th1-type response and, consequently, the -300*A/A type may be beneficial for viral elimination in chronic hepatitis C and IFN therapy...
  44. ncbi Association of IFN-gamma and IFN regulatory factor 1 polymorphisms with childhood atopic asthma
    F Nakao
    Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Japan
    J Allergy Clin Immunol 107:499-504. 2001
    ..IFN-gamma and related molecules play important roles in the differentiation and function of TH2 cells...
  45. ncbi Association of interferon-gamma and interferon regulatory factor 1 polymorphisms with asthma in a family-based association study in Taiwan
    T N Wang
    Faculty of Public Health, Kaohsiung Medical University, Kaohsiung, Taiwan
    Clin Exp Allergy 36:1147-52. 2006
    ..IFN-gamma and IFN regulatory factor 1 (IRF-1) affect Th1/Th2 cytokine balance, and influence the differentiation of Th2 cells, which influence the development of asthma...
  46. pmc Lack of association of interferon regulatory factor 1 with severe malaria in affected child-parental trio studies across three African populations
    Valentina D Mangano
    Childhood Infection Group, The Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom
    PLoS ONE 4:e4206. 2009
    b>Interferon Regulatory Factor 1 (IRF-1) is a member of the IRF family of transcription factors, which have key and diverse roles in the gene-regulatory networks of the immune system...
  47. ncbi IFN regulatory factor-1 regulates IFN-gamma-dependent cathepsin S expression
    Karin Storm van's Gravesande
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 168:4488-94. 2002
    ..Thus, IRF-1 is the critical transcriptional mediator of IFN-gamma-dependent cathepsin S activation. These data elucidate a new pathway by which IRF-1 may affect MHC class II processing and presentation...
  48. ncbi Interferon regulatory factor-1 promoter polymorphism and the outcome of hepatitis C virus infection
    Perdita Wietzke-Braun
    Division of Gastroenterology and Endocrinology, Georg August Universitat, Gottingen, Germany
    Eur J Gastroenterol Hepatol 18:991-7. 2006
    ....
  49. ncbi Arsenic enhances the apoptosis induced by interferon gamma: key role of IRF-1
    J El Bougrini
    UPR CNRS 9045, Institut André Lwoff 7 rue Guy Moquet, 94801 Villejuif, France
    Cell Mol Biol (Noisy-le-grand) 52:9-15. 2006
    ..These biological responses induced by IFNgamma alone or in combination with As2O3 were abolished when IRF-1 expression was down-regulated by RNA interference, thus demonstrating the key role of IRF-1...
  50. ncbi Analysis of MxA, IL-4, and IRF-1 genes in Filipino patients with subacute sclerosing panencephalitis
    J R Pipo-Deveza
    Section of Pediatric Neurology, Department of Pediatrics and Neurosciences, University of the Philippines, Philippine General Hospital, Taft Avenue, Manila, Philippines
    Neuropediatrics 37:222-8. 2006
    ..These genes have been suggested to play a role in the establishment of persistent viral infection in the central nervous system...
  51. ncbi Central role of interferon regulatory factor-1 (IRF-1) in controlling retinoic acid inducible gene-I (RIG-I) expression
    Zao Zhong Su
    Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, New York, New York 10032, USA
    J Cell Physiol 213:502-10. 2007
    ..IRF-1 is a tumor suppressor and the expression profile of RIG-I together with its regulation by IRF-1 and the presence of a caspase-recruitment domain in RIG-I suggest that RIG-I might also possess tumor suppressor properties...
  52. ncbi EGFR induces expression of IRF-1 via STAT1 and STAT3 activation leading to growth arrest of human cancer cells
    Peter Andersen
    Department of Radiation Biology, The Finsen Center, Copenhagen University Hospital, Copenhagen, Denmark
    Int J Cancer 122:342-9. 2008
    ....
  53. ncbi IFN-beta modulates the response to TLR stimulation in human DC: involvement of IFN regulatory factor-1 (IRF-1) in IL-27 gene expression
    Maria Elena Remoli
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    Eur J Immunol 37:3499-508. 2007
    ..Taken together, our results shed light on the capacity of IFN-beta to finely tune DC response to invading pathogens...
  54. ncbi IRF-1 gene variations influence IgE regulation and atopy
    Michaela Schedel
    University Children s Hospital, Ludwig Maximilian s University Munich, Lindwurmstrasse 4, D 80337 München, Germany
    Am J Respir Crit Care Med 177:613-21. 2008
    ..The development of atopic diseases is characterized by skewed immune responses to common allergens. Only recently, interferons have been identified to play a crucial role in these mechanisms...
  55. doi KAP1 regulates type I interferon/STAT1-mediated IRF-1 gene expression
    Shinya Kamitani
    Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita Ku Kita 12 Nishi 6, Sapporo 060 0812, Japan
    Biochem Biophys Res Commun 370:366-70. 2008
    ..These results indicate that KAP1 may act as an endogenous regulator of the IFN/STAT1 signaling pathway...
  56. pmc Cooperative regulation of the interferon regulatory factor-1 tumor suppressor protein by core components of the molecular chaperone machinery
    Vikram Narayan
    Cancer Research UK Interferon and Cell Signalling Group, Cell Signalling Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, Scotland, United Kingdom
    J Biol Chem 284:25889-99. 2009
    ..This study begins to elucidate the role of the Mf1 domain of IRF-1 in orchestrating the recruitment of regulatory factors that can impact on both its turnover and transcriptional activity...
  57. doi Lysophosphatidic acid inhibits CC chemokine ligand 5/RANTES production by blocking IRF-1-mediated gene transcription in human bronchial epithelial cells
    Shinichi Matsuzaki
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    J Immunol 185:4863-72. 2010
    ..LPA(1) coupled to G(i) and activation of PI3K is required for this unique effect...
  58. ncbi Isolation and characterization of a human STAT1 gene regulatory element. Inducibility by interferon (IFN) types I and II and role of IFN regulatory factor-1
    Lee H Wong
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3168, Australia
    J Biol Chem 277:19408-17. 2002
    ..Reciprocating regulation between IRF-1 and STAT1 genes and encoded proteins indicates that an intracellular amplifier circuit exists controlling cellular responsiveness to the IFNs...
  59. ncbi Host defense responses to infection by Mycobacterium tuberculosis. Induction of IRF-1 and a serine protease inhibitor
    Yaming Qiao
    Public Health Research Institute, Newark, New Jersey 07103, USA
    J Biol Chem 277:22377-85. 2002
    ..Therefore, we examined the expression of interferon regulatory factor 1 (IRF-1), which plays an important role in host defense against M...
  60. ncbi IFN-gamma represses IL-4 expression via IRF-1 and IRF-2
    Bernd Elser
    Tumorimmunology Program, German Cancer Research Center DKFZ, D 69120 Heidelberg, Germany
    Immunity 17:703-12. 2002
    ..Our data demonstrate a direct negative feedback of IFN-gamma on expression of the Th2 cytokine gene IL-4 and, thus, provide evidence for another important mechanism by which IFNgamma assists Th1 and attenuates Th2 responses...
  61. ncbi Interferon regulatory factor-1 (IRF-1) is a mediator for interferon-gamma induced attenuation of telomerase activity and human telomerase reverse transcriptase (hTERT) expression
    Seung Hoon Lee
    Molecular Therapy Research Center, College of Medicine, Sungkyunkwan University, Samsung Medical Center Annex 8F, Seoul, Korea
    Oncogene 22:381-91. 2003
    ..These findings provide evidence that IRF-1 is a potential mediator of IFN-gamma-induced attenuation of telomerase activity and hTERT expression...
  62. ncbi The tumor suppressor interferon regulatory factor 1 interferes with SP1 activation to repress the human CDK2 promoter
    Rong Lin Xie
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Biol Chem 278:26589-96. 2003
    Cell growth control by interferons (IFNs) involves up-regulation of the tumor suppressor interferon regulatory factor 1 (IRF1)...
  63. ncbi Enhanced expression of interferon regulatory factor-1 in the mucosa of children with celiac disease
    Virginia M Salvati
    Department of Pediatrics and European Laboratory for the Investigation of Food Induced Diseases, University Federico II, Naples, Italy
    Pediatr Res 54:312-8. 2003
    ....
  64. pmc Growth arrest of epithelial cells during measles virus infection is caused by upregulation of interferon regulatory factor 1
    Shin Ichi Yokota
    Department of Microbiology, Sapporo Medical University School of Medicine, Chuo Ku, Sapporo 060 8556, Japan
    J Virol 78:4591-8. 2004
    ..These results indicate that MeV upregulates IRF-1 in a manner that is independent of IFN but dependent on the JAK/STAT pathway. This induction of IRF-1 appears to suppress cell growth, although the extent seems to vary among MeV strains...
  65. ncbi Differential regulation of karyopherin alpha 2 expression by TGF-beta1 and IFN-gamma in normal human epidermal keratinocytes: evident contribution of KPNA2 for nuclear translocation of IRF-1
    Noriko Umegaki
    Department of Dermatology, Hirosaki University School of Medicine, Hirosaki, Japan
    J Invest Dermatol 127:1456-64. 2007
    ..Our data suggest that KPNA2 may play an important role in the signal-transduction pathways that regulate epidermal proliferation and differentiation...
  66. ncbi Polymorphisms in the interferon regulatory factor-1 promoter are not associated with psoriasis and do not influence IFN-alpha-induced Th1 polarization
    Leslie van der Fits
    Department of Immunology, University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Interferon Cytokine Res 27:841-6. 2007
    ..We further demonstrate that psoriatic PBMCs do not respond aberrantly to IFN-alpha with respect to the production of the proinflammatory IFN-gamma and the anti-inflammatory IL-10...
  67. pmc Leishmania major infection activates NF-kappaB and interferon regulatory factors 1 and 8 in human dendritic cells
    Asha Jayakumar
    Center for Global Health and Infectious Diseases, Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA
    Infect Immun 76:2138-48. 2008
    ..early activation of NF-kappaB transcription factors and the up-regulation and nuclear translocation of interferon regulatory factor 1 (IRF-1) and IRF-8...
  68. ncbi IFN regulatory factor-1 negatively regulates CD4+ CD25+ regulatory T cell differentiation by repressing Foxp3 expression
    Alessandra Fragale
    Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    J Immunol 181:1673-82. 2008
    ..We conclude that IRF-1 is a key negative regulator of CD4(+)CD25(+) Treg cells through direct repression of Foxp3 expression...
  69. doi FOXA1 and IRF-1 intermediary transcriptional regulators of PPARgamma-induced urothelial cytodifferentiation
    C L Varley
    Jack Birch Unit of Molecular Carcinogenesis, Department of Biology, University of York, York YO10 5YW, UK
    Cell Death Differ 16:103-14. 2009
    ....
  70. pmc Type I interferons and interferon regulatory factors regulate TNF-related apoptosis-inducing ligand (TRAIL) in HIV-1-infected macrophages
    Yunlong Huang
    Department of Pharmacology and Experimental Neuroscience, Laboratory of Neurotoxicology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 4:e5397. 2009
    ..We conclude that IRF-1, IRF-7, type I IFNs, and STAT1 form a signaling feedback loop that is critical in regulating TRAIL expression in HIV-1-infected macrophages...
  71. pmc Glucocorticoid receptor interacting protein-1 restores glucocorticoid responsiveness in steroid-resistant airway structural cells
    Reena Bhandare
    Department of Pharmaceutical Sciences, Thomas Jefferson University, Jefferson School of Pharmacy, 130 South 9th Street, Philadelphia, PA 19107 5233, USA
    Am J Respir Cell Mol Biol 42:9-15. 2010
    ....
  72. ncbi Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes
    H Harada
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    Cell 58:729-39. 1989
    ..Our results suggest that transcription of the IFN and IFN-inducible genes is regulated by two similar trans-acting factors that apparently compete for the same cis-acting recognition sequences, but which have opposite effects...
  73. ncbi Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-beta gene regulatory elements
    M Miyamoto
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    Cell 54:903-13. 1988
    ..Surprisingly, IRF-1 gene expression is dramatically induced by Newcastle disease virus in mouse L929 cells and by Concanavalin A in spleen cells. We show here that the IRF-1 gene possesses virus-inducible promoter...
  74. pmc Structure and regulation of the human interferon regulatory factor 1 (IRF-1) and IRF-2 genes: implications for a gene network in the interferon system
    H Harada
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    Mol Cell Biol 14:1500-9. 1994
    b>Interferon regulatory factor 1 (IRF-1) and IRF-2 are structurally similar DNA-binding factors which were originally identified as regulators of the type I interferon (IFN) system; the former functions as a transcriptional activator, and ..
  75. ncbi NF kappa B and interferon regulatory factor 1 physically interact and synergistically induce major histocompatibility class I gene expression
    P D Drew
    Neuroimmunology Branch, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    J Interferon Cytokine Res 15:1037-45. 1995
    ..These results provide a molecular mechanism by which TNF-alpha and IFN-gamma synergistically induce the expression of a variety of genes involved in immune responses, including MHC class I...
  76. ncbi Recruitment of CBP/p300 by the IFN beta enhanceosome is required for synergistic activation of transcription
    M Merika
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Mol Cell 1:277-87. 1998
    ..Deletion, substitution, or rearrangement of any one of the activation domains in the context of the enhanceosome decreases both recruitment of CBP and transcriptional synergy...
  77. pmc Functional domains of interferon regulatory factor I (IRF-1)
    F Schaper
    Gesellschaft fur Biotechnologische Forschung mbH, Mascheroder Weg 1, 38124 Braunschweig, Federal Republic of Germany
    Biochem J 335:147-57. 1998
    ..Epitope mapping of IRF-1 showed that regions within the NLS, the heterodimerization domain and the transcriptional activation domain are exposed for possible contacts with interacting proteins...
  78. ncbi The role of interferon regulatory factors in the interferon system and cell growth control
    H Harada
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Biochimie 80:641-50. 1998
    ....
  79. ncbi A role for casein kinase II phosphorylation in the regulation of IRF-1 transcriptional activity
    R Lin
    Lady Davis Institute for Medical Research, and Department of Medicine, McGill University, Montreal, Quebec, Canada
    Mol Cell Biochem 191:169-80. 1999
    ..The present experiments, together with previously published studies with IkappaBalpha, c-Jun and other proteins, indicate a broad role for casein kinase II phosphorylation in the regulation of transcription factor activity...
  80. ncbi Inactivation of interferon regulatory factor-1 tumor suppressor protein by HPV E7 oncoprotein. Implication for the E7-mediated immune evasion mechanism in cervical carcinogenesis
    J S Park
    Department of Obstetrics and Gynecology, Catholic University Medical College, Seoul, 137 040 Korea
    J Biol Chem 275:6764-9. 2000
    ..The immune-promoting role of IRF-1 evokes the idea that our novel finding might be important for the elucidation of the E7-mediated immune evading mechanism that is frequently found in cervical cancer...
  81. ncbi HIV-1 Nef activates STAT1 in human monocytes/macrophages through the release of soluble factors
    M Federico
    Laboratory of Virology, Istituto Superiore di Sanita, Rome, Italy
    Blood 98:2752-61. 2001
    ..Taken together, the results indicate that HIV-1 Nef could interfere with STAT1-governed intracellular signaling in human monocytes/macrophages...
  82. pmc Ectopic expression of interferon regulatory factor-1 potentiates granulocytic differentiation
    E M Coccia
    Laboratory of Virology, Istituto Superiore di Sanita, Viale Regina Elena, 299 00161 Rome, Italy
    Biochem J 360:285-94. 2001
    ..We conclude that IRF-1 exerts a pivotal role in granulocytic differentiation and that its induction by G-CSF represents a limiting step in the early events of differentiation...
  83. ncbi Activities of IRF-1
    Andrea Kröger
    Department of Gene Regulation and Differentiation, GBF, Gesellschaft fur Biotechnologische Forschung, D 38124 Braunschweig Mascheroder Weg 1, Germany
    J Interferon Cytokine Res 22:5-14. 2002
    ....
  84. ncbi IRF-1 as a negative regulator of cell proliferation
    Giovanna Romeo
    Laboratory of Virology, Istituto Superiore di Sanita, Rome, Italy
    J Interferon Cytokine Res 22:39-47. 2002
    ....
  85. pmc Modulation of human immunodeficiency virus 1 replication by interferon regulatory factors
    Marco Sgarbanti
    Laboratory of Virology, Istituto Superiore di Sanita, 00161 Rome, Italy
    J Exp Med 195:1359-70. 2002
    ....
  86. ncbi Regulation of the IRF-1 tumour modifier during the response to genotoxic stress involves an ATM-dependent signalling pathway
    Jessica Pamment
    Cancer Research UK Laboratories, University of Dundee Medical School, Dundee DD1 9SY, UK
    Oncogene 21:7776-85. 2002
    ..Thus, IRF-1 is controlled by two distinct signalling pathways; a JAK/STAT-signalling pathway in viral infected cells and an ATM-signalling pathway in DNA damaged cells...
  87. ncbi The up-regulation of human caspase-8 by interferon-gamma in breast tumor cells requires the induction and action of the transcription factor interferon regulatory factor-1
    Carmen Ruiz-Ruiz
    Instituto de Parasitologia y Biomedicina, CSIC, Calle Ventanilla 11, 18001 Granada, Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Madrid E 28049, Spain
    J Biol Chem 279:19712-20. 2004
    ..These data define a new pathway through which IFN-gamma might control the sensitivity of tumor cell to death receptor-mediated apoptosis...
  88. ncbi interferon regulatory factor-1 mediates the proapoptotic but not cell cycle arrest effects of the steroidal antiestrogen ICI 182,780 (faslodex, fulvestrant)
    Kerrie B Bouker
    Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, District of Columbia 20007, USA
    Cancer Res 64:4030-9. 2004
    ..These data identify a novel mechanism of antiestrogen resistance and implicate IRF-1 as a key component in signaling some ER-mediated effects on apoptosis/cell survival...
  89. pmc Interferon regulatory factor 1 (IRF-1) and IRF-2 distinctively up-regulate gene expression and production of interleukin-7 in human intestinal epithelial cells
    Shigeru Oshima
    Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Mol Cell Biol 24:6298-310. 2004
    ....
  90. pmc Tumor suppressor IRF-1 mediates retinoid and interferon anticancer signaling to death ligand TRAIL
    Nicole Clarke
    Department of Cell Biology and Signal Transduction, Institut de Genetique et de Biologie Moleculaire et Cellulaire CNRS INSERM ULP, Illkirch, CU de Strasbourg, France
    EMBO J 23:3051-60. 2004
    ..These data argue for combination therapies that activate the TRAIL pathway to eradicate tumor cells...
  91. ncbi Synergistic activation of interleukin-12 p35 gene transcription by interferon regulatory factor-1 and interferon consensus sequence-binding protein
    Jianguo Liu
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    J Biol Chem 279:55609-17. 2004
    ..This study provides novel mechanistic information on how signals initiated during innate and adaptive immune responses synergize to yield greater IL-12 production and sustained cellular immunity...
  92. ncbi IFN-gamma enhances TRAIL-induced apoptosis through IRF-1
    Sang Youel Park
    Bio Safety Research Institute, College of Veterinary Medicine, Chonbuk National University, Jeonju, Jeonbuk, South Korea
    Eur J Biochem 271:4222-8. 2004
    ..Therefore, our data indicate that IFN-gamma enhances TRAIL-induced apoptosis through IRF-1...
  93. ncbi Ectopic expression of interferon regulatory factor-1 promotes human breast cancer cell death and results in reduced expression of survivin
    Eva Pizzoferrato
    Department of Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA
    Cancer Res 64:8381-8. 2004
    ..Collectively, these observations suggest that therapies designed to enhance IRF-1 expression within tumor cells may represent novel treatment strategies for breast cancer...
  94. ncbi IRF-1 mediates upregulation of LMP7 by IFN-gamma and concerted expression of immunosubunits of the proteasome
    Shin Namiki
    Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Bunkyo ku, Japan
    FEBS Lett 579:2781-7. 2005
    ..These results suggest that IRF-1 acts as a master regulator for the concerted expression of immunoproteasome components...
  95. ncbi Alternative splicing variants of IRF-1 lacking exons 7, 8, and 9 in cervical cancer
    Eun Ju Lee
    Molecular Therapy Research Center, Sungkyunkwan University, Seoul 135 710, Republic of Korea
    Biochem Biophys Res Commun 347:882-8. 2006
    The two previously identified major splice variants of interferon regulatory factor 1 (IRF-1) do not appear to affect IRF-1-mediated gene activation. We searched for additional splice variants and examined their effect on wild-type IRF-1...
  96. ncbi Associations between interferon regulatory factor-1 polymorphisms and Behçet's disease
    Yun Jong Lee
    Department of Internal Medicine, Medical Research Center, Seoul National University College of Medicine, Seoul, Korea
    Hum Immunol 68:770-8. 2007
    ..5%, OR = 3.7147, 95% CI = 1.778-7.770, p(c) = 0.0015). These results suggest that IRF-1 is a novel susceptibility gene in BD, especially in women, and furthermore, that IRF-1 polymorphisms may be related to thrombosis in BD patients...
  97. pmc Interferon regulatory factor-1 polymorphisms are associated with the control of Plasmodium falciparum infection
    V D Mangano
    Dipartimento di Scienze di Sanità Pubblica, Sezione di Parassitologia, Universita di Roma La Sapienza, Rome, Italy
    Genes Immun 9:122-9. 2008
    ..02). These findings provide the first evidence of the involvement in malaria susceptibility of a specific locus within the 5q31 region, previously shown to be linked with P. falciparum infection levels...
  98. pmc CD40 induces antigen transporter and immunoproteasome gene expression in carcinomas via the coordinated action of NF-kappaB and of NF-kappaB-mediated de novo synthesis of IRF-1
    Aristides Moschonas
    Division of Basic Sciences, University of Crete Medical School, Heraklion, Crete, Greece
    Mol Cell Biol 28:6208-22. 2008
    ..overcomes this defect through the coordinated action of the transcription factors NF-kappaB and interferon regulatory factor 1 (IRF-1)...
  99. doi No evidence for association between the interferon regulatory factor 1 (IRF1) gene and clinical tuberculosis
    Sabine Vollstedt
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Japan
    Tuberculosis (Edinb) 89:71-6. 2009
    b>Interferon regulatory factor 1 is a transcription factor involved in initiating a vigorous Th1 response during Mycobacterium tuberculosis infection...
  100. pmc Docking-dependent ubiquitination of the interferon regulatory factor-1 tumor suppressor protein by the ubiquitin ligase CHIP
    Vikram Narayan
    CRUK Interferon and Cell Signalling Group, Cell Signalling Unit, Institute of Genetics and Molecular Medicine, Crewe Road South, University of Edinburgh, Edinburgh EH4 2XR, United Kingdom
    J Biol Chem 286:607-19. 2011
    ..The study reveals a complex relationship between CHIP and IRF-1 and highlights the role that direct binding or "docking" of CHIP to its substrate(s) can play in its mechanism of action as an E3 ligase...
  101. pmc Epigenetic control of IRF1 responses in HIV-exposed seronegative versus HIV-susceptible individuals
    Ruey Chyi Su
    Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada
    Blood 117:2649-57. 2011
    ..These data suggest that transitory IRF1 responsiveness in HIV-R may be one of the key contributors to the altered susceptibility to HIV infection during the early stages of primary HIV infection...

Research Grants65

  1. NEW NUCLEAR MATRIX PROTEIN IN BREAST CANCER GROWTH
    Steffi Oesterreich; Fiscal Year: 2002
    ..analyzing HET and found that HET indeed is a nuclear matrix protein, that it can bind to matrix attachment regions (MAR), and that it acts as a transcriptional repressor...
  2. INFERRING CHROMOSOME ARCHITECTURE FROM GENOMIC SEQUENCE
    Craig Benham; Fiscal Year: 2002
    ..method to calculate destabilization profiles of superhelical DNA sequences containing known S/MARs, the S/MAR sites coincide with regions of extensive destabilization...
  3. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  4. Variation in M. tuberculosis in response to host selection
    Sarah Fortune; Fiscal Year: 2009
    ..In these studies, we expect to provide fundamental insights into the mechanisms and targets of diversifying immune selection in M. tuberculosis. ..
  5. Novel TIRF microscopy analyzing trafficking & signaling at the cell cortex
    Derek Toomre; Fiscal Year: 2009
    ..Consistent with the recovery act's goal, this funding will provide full-time summer employment for 4 undergraduate students and accelerate scientific achievement of the parent DP2 award...
  6. Lionel B Ivashkiv; Fiscal Year: 2016
    ..We anticipate that these studies will yield insights about specific regulation of subsets of TLR-inducible cytokines and genes that will be useful in developing therapeutic approaches to modulate specific innate immune functions. ..
  7. WILLIAM MAURICE SHAFER; Fiscal Year: 2016
    ..a repressor of the mtrCDE efflux pump operand and can control the expression of numerous genes outside of the mar locus...
  8. FUNCTION OF MATRIX ATTACHMENT REGIONS IN THE IG LOCI
    ANN FEENEY; Fiscal Year: 2000
    Matrix attachment regions (MAR) are AT-rich regions of DNA which mediate attachment of the chromosome to the nuclear matrix. MARs have been studied in a few model loci, two of which are the IgH and Ig- kappa loci...
  9. TOMASZ K KORDULA; Fiscal Year: 2016
    ..This proposal will enhance understanding of how the intricate interplay between IL-1, S1P and its receptors in astrocytes regulates inflammation and could pave the way for the design of even more effective MS therapies. ..
  10. Base unpairing regions and chromatin folding
    Terumi Kohwi Shigematsu; Fiscal Year: 2004
    ..We have previously cloned a cell-type specific MAR-binding protein, SATB 1, which is expressed in thymocytes and activated T cells...
  11. NON B DNA STRUCTURE WITH CHEMICAL CARCINOGENS
    Terumi Kohwi Shigematsu; Fiscal Year: 2001
    ..SATB1 is a cell-type specific MAR-binding protein which is predominantly expressed in thymocytes...
  12. Tahir Hussain; Fiscal Year: 2016
    ..We propose to investigate the role of a novel target, namely the Angiotensin II AT2 receptor, to improve kidney function and lower blood pressure in an obesity/diabetic animal model. ..
  13. INTERFERON REGULATORY FACTOR 2 FUNCTIONS
    George Blanck; Fiscal Year: 2002
    ..If so, this would be the first demonstration of a role for IRF-2 mutations in human tumor. Methods: EMSA, in vivo footprinting, DNA transfection, DNA sequencing, DNA cloning. ..
  14. Pharmacological vaccine adjuvants: analysis of immune responses to vaccines
    Jeannine M Durdik; Fiscal Year: 2010
    ..This work will define the sorts of vaccines that these pharmacological interventions can be useful with, their potential utility in the compromised immune responses of elderly individuals, and their biochemical mechanisms of action. ..
  15. Peilin Li; Fiscal Year: 2014
    ....
  16. IRF1 regulation of BCL2 family members determines breast cancer cell fate
    JESSICA LEA ROBERTS; Fiscal Year: 2013
    ..The studies will also determine whether induction of IRF1 signaling can improve responsiveness to AEs when combined with a BCL2 inhibitor. ..
  17. Liver Antigen - Presenting Cells in Hepatic Injury and Transplantation
    Angus W Thomson; Fiscal Year: 2010
    ..These three Projects will be supported by an Administrative Core (Core A), that will co-ordinate programatic functions, an Imaging and Tissue Pathology Core (Core B). and a small animal Transplantation Surgery Core (Core C). ..
  18. Interferon gamma-mediated restriction of Shigella flexneri replication
    Michael N Starnbach; Fiscal Year: 2013
    ..flexneri, we discovered that the IFN?-inducible transcription factor interferon regulatory factor 1 (IRF1) is critical for S. flexneri growth restriction...
  19. Mitochondrial AntiViral Signaling Protein, IRF1, and Ischemic AKI
    Christopher Y Lu; Fiscal Year: 2013
    ..during ischemic AKI activate MAVS (Mitochondria Anti-Viral Signaling protein), MAVS activates IRF1 (interferon regulatory factor 1), and IRF1 stimulates the production of maladaptive [unreadable]-IFNs (alpha interferons)...
  20. Kelvin J A Davies; Fiscal Year: 2016
    ..H2O2-induced expression of Pa28? and Proteasome, through Nrf2 homologs skn-1 and cnc-C, also decays during aging of C. elegans and D. melanogaster, contributing to age-related decline in overall stress resistance and adaptability. ..
  21. OXYGEN RADICAL TOXICITY AND PROTEIN DEGRADATION
    Kelvin J A Davies; Fiscal Year: 2012
    ..H2O2-induced expression of Pa28 and Proteasome, through the Nrf2 homologs skn-1 and cnc-C, also decays during aging of C. elegans and D. melanogaster, contributing to an age-related decline in overall stress resistance and adaptability. ..
  22. Jessie Yester; Fiscal Year: 2014
    ..Our preliminary data show that IL-1 induces expression of transcription factor interferon regulatory factor 1 (IRF-1) in astrocytes...
  23. MAR MEDIATED CONTROL OF THE IgH ENHANCER
    Haley O Tucker; Fiscal Year: 2012
    ..By understanding more about Foxp1 and the genes deregulated by its over-expression, we can better understand basic mechanisms underlying DLBCL. PHS 398/2590 ..
  24. INTERACTION OF CIS-ACTING ELEMENTS IN CD8 REGULATION
    Philip Tucker; Fiscal Year: 2005
    ..The L2a element is a nuclear matrix associated region (or MAR). Interestingly, inclusion of both the E81 enhancer and a 4...
  25. EFFECTS OF CHROMATIN ARCHITECTURE ON ORIGIN ACTIVITY
    PIETER DIJKWEL; Fiscal Year: 2003
    ..and ori-gamma are separated by approximately 20 kb and straddle a permanent matrix attachment region (MAR)...
  26. Molecular Genetic Study of Repair of Radiation Damage
    THOMAS STAMATO; Fiscal Year: 2003
    ..have found find that DNA-ends will bind preferentially to circular plasmid DNA containing matrix attachment region (MAR) DNA sequences and that this interaction requires the DNA-end-binding protein Ku, DNA dependent protein kinase ..
  27. Leaf Huang; Fiscal Year: 2016
    ..In Aim 3, we will test the IFN gene therapy in the AFC8-hu mice chronically infected with HBV. S/MAR sequence will be incorporated into the IFN-[unreadable]2b plasmid to prolong the gene expression...
  28. TARGETING CELLULAR ONCOGENES WITH DNA-REACTIVE DRUGS
    Jan Woynarowski; Fiscal Year: 2000
    ..other AT-specific, DNA-reactive drugs to preferentially affect the replication domains, matrix associated region (MAR) and origin of replication (ORI) of the c-myc gene...
  29. FUNCTIONAL ANALYSIS OF THE IG LOCUS CONTROL REGION
    WILLIAM FORRESTER; Fiscal Year: 2002
    ..the enhancer and distal promoters, the PI proposes the following 3 specific aims: 1) To identify the specific MAR sequences necessary for LCR function, 2) To identify MAR-binding protein factors which are a functional component ..
  30. Functional attributes of CD8+ T cells in recovery of hepatitis C virus infection
    HUGO RAMON ROSEN; Fiscal Year: 2013
    ..Clin Gastroenterol Hepatol. 2007 Apr;5(4):508- 12. Epub 2007 Mar 26 Ho SB, Groessl E, Dollarhide A, Robinson S, Kravetz D, Dieperink E...
  31. Chandrashekhar R Gandhi; Fiscal Year: 2016
    ..Such understanding is expected to highlight future avenues in developing effective treatment options, particularly in blocking the responses of HSCs to LPS or the specific signaling pathways responsible for hepatocyte injury. ..
  32. Stephan K Schwander; Fiscal Year: 2016
    ..tb infection. Given the wide geographical scales for both air pollution and M.tb infections, new knowledge to be gained from this study will have significant global health implications. ..
  33. CD24 Polymorphism and Acetaminophen Toxicity
    Pan Zheng; Fiscal Year: 2010
    ..2009 mar 5...
  34. Carlos A Camargo; Fiscal Year: 2015
    ..This URI subcohort will receive special mailings in Feb/Mar 2012 (baseline), Oct/Nov 2012, and Feb/Mar 2013 (same season, 1 year later)...
  35. CHARLES NICHOLAS SERHAN; Fiscal Year: 2016
    ..In work in progress, we found Rv (i.e. RvD1) and a new family of mediators coined maresins (MaR) that regulate both PMN and M&responses critical for resolution...
  36. Mara Z Vitolins; Fiscal Year: 2014
    ..4%. Since Aug. 2007, we have enrolled 258 participants, and we plan to enroll 42 more by Mar. 2009. Follow-up was funded for a uniform 2 years;hence, the earliest-enrolled participants (enrolled in Aug...
  37. Development of an Antimicrobial Cellular Therapeutic for Inhibition of Biofilm Fo
    ALLEN R COMER; Fiscal Year: 2013
    ..2009 mar;17(3):562-9)...
  38. Karin M Nelson; Fiscal Year: 2014
    ..from the local Veterans Affairs (VA) hospital, the county hospital (Harborview) and a community health center (Sea Mar). Our primary outcome will be glycemic control as measured by a HbA1c...
  39. Innate Immunity and Herpes Simplex Infection
    ROBERT WILLIAM FINBERG; Fiscal Year: 2010
    ..All Projects involve the use of common reagents and the definition of new paradigms related to recognition and response of the host to HSV. ..
  40. Yaron Tomer; Fiscal Year: 2015
    ..Our translational studies will hopefully lead to novel therapies for AITD. ..
  41. Approaches for genomic mapping of 5-hydroxymethylcytosine a novel epigenetic mar
    Saulius Klimasauskas; Fiscal Year: 2011
    ..Our new technologies for the analysis of the 6th base, namely 5-hydroxymethylcytosine, will be an incredibly valuable addition to the "tool box" of comprehensive genomic studies. ..
  42. Conversational Engagement as a Means to Delay Alzheimer's Disease Onset
    HIROKO HAYAMA DODGE; Fiscal Year: 2012
    ..conversations, we will utilize a wearable, voice activated digital recorder called the MicroDot Audio Recorder (MAR), which unobtrusively records the amount of time spent talking by the participants...
  43. David R Plas; Fiscal Year: 2016
    ..adapted to decreased glycolysis in the absence of S6K1 signaling, initiating a Metabolic Adaptive Response, or MAR, to mediate cancer cell survival despite S6K1 inactivation...
  44. CLAYTON THOMAS BAUER; Fiscal Year: 2015
    ..development of alternative medical treatments with lower abuse liabilities and to new strategies for treatment of MAR abuse...
  45. Stuart B Levy; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The multiple antibiotic resistance (mar) operon of the enteric bacterium Escherichia coli regulates multiple antibiotic resistance and pathogenicity...
  46. ECM-Mediated Apoptosis in p53 (-) HMECs
    Victoria L Seewaldt; Fiscal Year: 2010
    ..Significance: Completions of these aims will provide insight into early events in ER(-) mammary carcinogenesis and provide novel targets for breast cancer chemoprevention. ..
  47. John Nicholas; Fiscal Year: 2016
    ....
  48. Catherine W Morgans; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Melanoma Associated Retinopathy (MAR) is a paraneoplastic visual syndrome associated with cutaneous malignant melanoma in which patients typically experience a sudden decrease in night vision and ..
  49. Quantitative Proteomic Reconfiguration in Induction of Neuroprotection against St
    An Zhou; Fiscal Year: 2012
    ..However, we now show the tolerance proteome (Stapels et al. Science Signaling, Mar 2010)...
  50. Young Bong Choi; Fiscal Year: 2014
    ..This proposal will thus examine a novel paradigm of virus-host interaction, and potentially provide a basis for future development of novel antiviral agents based on the identified interactions and mechanisms. ..
  51. Anti-HIV activity in genital tract secretions of postmenopausal women
    Mimi Ghosh; Fiscal Year: 2013
    ..2011 Mar;65(3):196-211),there remains a major gap in our understanding regarding the extent of loss of innate immune ..
  52. Molecular markers of breast cancer risk and prevention
    Victoria L Seewaldt; Fiscal Year: 2010
    ....
  53. Funtional Genomics of Interferon for Tuberculosis
    Richard Pine; Fiscal Year: 2005
    ..This analysis will further the understanding of cellular immunity in tuberculosis and gene expression regulated by IFNgamma. ..
  54. Inhibition of lupus nephritis in IRF-1 deficient mice
    Christopher Reilly; Fiscal Year: 2003
    ..Specific Aim 2: Study the in vivo effect of gene deletion of IRF-1 on MRL/lpr mice by backcrossing C57BL6 (IRF-1- /-) mice onto the MRL/lpr background. ..
  55. Phase II SER-CAT Optimization: Acquisition of a next generation area detector
    Bi Cheng Wang; Fiscal Year: 2010
    ..importantly;the MX300 detector will serve as a needed backup for 22ID with the MAR 225 installed back on 22BM, in the event of 22ID detector failure...
  56. BRUCELLA VACCINE FOR BIOTERRORISM
    Gary Splitter; Fiscal Year: 2003
    ..Importantly, no Brucella vaccine is available for humans, and there is an immediate need to protect the public against Brucella that might be used by bioterrorists. ..
  57. ANTITUMOR-ANTIBIOTICS FROM MARINE MICROORGANISMS
    William Fenical; Fiscal Year: 2013
    ..the renewal application will be on 7 new groups of obligate marine actinomycetes (Salinospora, Marinomyces, and the MAR 3-7 groups) discovered during the past 24 months...
  58. Interferon gamma in autoimmune thyroiditis & thyroid function
    Patrizio Caturegli; Fiscal Year: 2007
    ..We also hypothesize that augmented TSH signaling is required to induce the adipocyte-rich phenotype, and cross thyr-IFNg transgenics to TSH receptor knockout mice. ..
  59. A DIAGNOSTIC TEST TO ASSESS RISK ASSOCIATED WITH ANDROGEN THERAPY
    Meharvan Singh; Fiscal Year: 2007
    ..receptor), subserves a beneficial (cell survival promoting) effect, while the other, a membrane androgen receptor (mAR), promotes cell death...
  60. Acquisition of Rigaku MicroMax-007 HF lab x-ray system
    Eaton E Lattman; Fiscal Year: 2010
    ..The Institute currently houses two image plate detectors, one a MAR 345 unit on loan from Stanford and the other our workhorse, an R AXIS IV sited on a RU-H3RHB generator...
  61. CRITICAL ROLE OF HHV8 ENCODED IRF IN AIDS LYMPHOMAS
    PAULA PITHA ROWE; Fiscal Year: 2001
    ..Lastly, the vIRF transgenic mice may represent an experimental model for future therapeutical studies of AIDS-associated lymphomas. ..
  62. Molecular Consequences of Estrogen-Induced Interferony
    S Ahmed; Fiscal Year: 2007
    ..1 Description, ..
  63. Assessing / Developing Methods for Complex Dependent Data
    John M Neuhaus; Fiscal Year: 2013
    ..However, they may be sensitive to data which are missing at random (MAR), but not missing completely at random (MCAR)...
  64. GRAM+ ANTIMICROBIALS TARGETED TO DNA POLYMERASE III
    George Wright; Fiscal Year: 2000
    ..objective of this project is to develop new antibiotics to treat infections with multi-antibiotic-resistant (MAR) Gram+ bacteria, especially Staphylococcus aureus and Enterococcus fecalis...
  65. IRF 1 AND PROLACTIN IN T CELL ACTIVATION
    Li Yuan Yu Lee; Fiscal Year: 1999
    ..Understanding how PRL modulates the biological functions of T cells should elucidate the immunoregulatory properties of PRL, and provide new insights into neuroendocrine-immune system interactions. ..