IRAS

Summary

Gene Symbol: IRAS
Description: nischarin
Alias: IR1, IRAS, hIRAS, nischarin, I-1 receptor candidate protein, I1R candidate protein, imidazoline receptor 1, imidazoline receptor antisera selected
Species: human

Top Publications

  1. ncbi Characterization of a partial cDNA clone detected by imidazoline receptor-selective antisera
    T R Ivanov
    Department of Psychiatry, University of Mississippi Medical Center, Jackson 39216 4505, USA
    J Auton Nerv Syst 72:98-110. 1998
  2. ncbi Promoter (4G/5G) plasminogen activator inhibitor-1 genotype and plasminogen activator inhibitor-1 levels in blacks, Hispanics, and non-Hispanic whites: the Insulin Resistance Atherosclerosis Study
    Andreas Festa
    Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78228 3900, USA
    Circulation 107:2422-7. 2003
  3. ncbi Nitrite and nitrate formation on model NO(x) storage materials: on the influence of particle size and composition
    A Desikusumastuti
    , , Egerlandstr 3, D 91058, Erlangen, Germany
    Phys Chem Chem Phys 11:2514-24. 2009
  4. doi Bile duct paucity is part of the neonatal ichthyosis-sclerosing cholangitis phenotype
    I F Nagtzaam
    Department of Dermatology, Maastricht University Medical Centre, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Br J Dermatol 163:205-7. 2010
  5. ncbi Low insulin sensitivity (S(i) = 0) in diabetic and nondiabetic subjects in the insulin resistance atherosclerosis study: is it associated with components of the metabolic syndrome and nontraditional risk factors?
    Steven M Haffner
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Diabetes Care 26:2796-803. 2003
  6. ncbi Claudin-1 gene mutations in neonatal sclerosing cholangitis associated with ichthyosis: a tight junction disease
    Smail Hadj-Rabia
    Département de génétique, Hopital Necker Enfants Malades, Paris, France
    Gastroenterology 127:1386-90. 2004
  7. doi Comparison of agmatine with moxonidine and rilmenidine in morphine dependence in vitro: role of imidazoline I(1) receptors
    Fei Li
    Beijing Institute of Pharmacology and Toxicology, 27th Taiping Road, Beijing 100850, China
    Eur J Pharmacol 612:1-8. 2009
  8. pmc Association of plasma vitamin D levels with adiposity in Hispanic and African Americans
    Kendra A Young
    Colorado School of Public Health, University of Colorado Denver, 13001 East 17th Place, Aurora, Colorado 80045, USA
    J Clin Endocrinol Metab 94:3306-13. 2009
  9. ncbi Dietary patterns, insulin sensitivity and adiposity in the multi-ethnic Insulin Resistance Atherosclerosis Study population
    Angela D Liese
    Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia 29208, USA
    Br J Nutr 92:973-84. 2004
  10. doi Not the next IRA: how health savings accounts shape public opinion
    Jason Barabas
    Florida State University, USA
    J Health Polit Policy Law 34:181-217. 2009

Research Grants

  1. KRISTEN GILL HAIRSTON; Fiscal Year: 2014
  2. Genetic Determinants of Visceral Adiposity
    Yongmei Liu; Fiscal Year: 2013
  3. Genetic &Epidemiologic Predictors of Glucose Homeostasis Measures in Hispanics
    Richard M Watanabe; Fiscal Year: 2013
  4. Intergration of Functional and Molecular Genetics to Identify Diabetes Genes
    Donald W Bowden; Fiscal Year: 2012
  5. Insulin Resistance and Adenomas of the Colorectum
    Mohammed Saad; Fiscal Year: 2003
  6. Insulin Resistance and Adenomas of the Colorectum
    Tim Byers; Fiscal Year: 2003
  7. Insulin Resistance and Adenomas of the Colorectum
    Theodore Levin; Fiscal Year: 2003
  8. Hippocampal plasticity in co-morbid diabetes and depression
    LAWRENCE P contact REAGAN; Fiscal Year: 2010
  9. Lawrence P Reagan; Fiscal Year: 2016
  10. GLYCEMIA AND RELATED MECHANISMS OF MACROVASCULAR DISEASE
    Lynne Wagenknecht; Fiscal Year: 1999

Detail Information

Publications162 found, 100 shown here

  1. ncbi Characterization of a partial cDNA clone detected by imidazoline receptor-selective antisera
    T R Ivanov
    Department of Psychiatry, University of Mississippi Medical Center, Jackson 39216 4505, USA
    J Auton Nerv Syst 72:98-110. 1998
    ..In situ hybridization histochemistry revealed an enrichment of the message in neuronal cell bodies of the rat hippocampus and cerebellar cortex. This clone has some of the properties expected of an imidazoline receptor...
  2. ncbi Promoter (4G/5G) plasminogen activator inhibitor-1 genotype and plasminogen activator inhibitor-1 levels in blacks, Hispanics, and non-Hispanic whites: the Insulin Resistance Atherosclerosis Study
    Andreas Festa
    Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78228 3900, USA
    Circulation 107:2422-7. 2003
    ..The 4G/5G polymorphism of the plasminogen activator inhibitor-1 (PAI-1) gene has been related to cardiovascular disease...
  3. ncbi Nitrite and nitrate formation on model NO(x) storage materials: on the influence of particle size and composition
    A Desikusumastuti
    , , Egerlandstr 3, D 91058, Erlangen, Germany
    Phys Chem Chem Phys 11:2514-24. 2009
    ..has been investigated by molecular beam (MB) methods and time-resolved IR reflection absorption spectroscopy (TR-IRAS) in combination with structural characterization by scanning tunneling microscopy (STM)...
  4. doi Bile duct paucity is part of the neonatal ichthyosis-sclerosing cholangitis phenotype
    I F Nagtzaam
    Department of Dermatology, Maastricht University Medical Centre, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Br J Dermatol 163:205-7. 2010
    ..Although the two conditions cannot always be easily distinguished, we would suggest that paucity of bile ducts could be a manifestation of NISCh...
  5. ncbi Low insulin sensitivity (S(i) = 0) in diabetic and nondiabetic subjects in the insulin resistance atherosclerosis study: is it associated with components of the metabolic syndrome and nontraditional risk factors?
    Steven M Haffner
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Diabetes Care 26:2796-803. 2003
    ..To determine the meaning of S(i) = 0 derived from the frequently sampled intravenous glucose tolerance test...
  6. ncbi Claudin-1 gene mutations in neonatal sclerosing cholangitis associated with ichthyosis: a tight junction disease
    Smail Hadj-Rabia
    Département de génétique, Hopital Necker Enfants Malades, Paris, France
    Gastroenterology 127:1386-90. 2004
    ..We considered claudin-1 to be a strong candidate gene based on its mapping to the minimum interval and on the expression pattern of the mouse ortholog...
  7. doi Comparison of agmatine with moxonidine and rilmenidine in morphine dependence in vitro: role of imidazoline I(1) receptors
    Fei Li
    Beijing Institute of Pharmacology and Toxicology, 27th Taiping Road, Beijing 100850, China
    Eur J Pharmacol 612:1-8. 2009
    ..Chinese hamster ovary cells co-expressing mu opioid receptor and imidazoline receptor antisera-selected protein (IRAS), the strong candidate for imidazoline I(1) receptor, were used as the cell line...
  8. pmc Association of plasma vitamin D levels with adiposity in Hispanic and African Americans
    Kendra A Young
    Colorado School of Public Health, University of Colorado Denver, 13001 East 17th Place, Aurora, Colorado 80045, USA
    J Clin Endocrinol Metab 94:3306-13. 2009
    ....
  9. ncbi Dietary patterns, insulin sensitivity and adiposity in the multi-ethnic Insulin Resistance Atherosclerosis Study population
    Angela D Liese
    Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia 29208, USA
    Br J Nutr 92:973-84. 2004
    ..insulin sensitivity (SI) and adiposity in the multi-ethnic, multi-centre Insulin Resistance Atherosclerosis Study (IRAS, 1992-94)...
  10. doi Not the next IRA: how health savings accounts shape public opinion
    Jason Barabas
    Florida State University, USA
    J Health Polit Policy Law 34:181-217. 2009
    ..Statistical analyses show that owners of Individual Retirement Accounts (IRAs) and Health Savings Accounts (HSAs) experience policy feedback effects, but in opposite directions...
  11. ncbi Treatment of instent restenosis following stent-supported renal artery angioplasty
    Thomas Zeller
    Department of Angiology, Herz Zentrum Bad Krozingen, Bad Krozingen, Germany
    Catheter Cardiovasc Interv 70:454-9. 2007
    We prospectively studied the long-term outcome of endovascular treatment of instent renal artery stenosis (IRAS).
  12. pmc Insulin resistance, beta cell dysfunction and visceral adiposity as predictors of incident diabetes: the Insulin Resistance Atherosclerosis Study (IRAS) Family study
    A J G Hanley
    Department of Nutritional Sciences, University of Toronto, ON, Canada
    Diabetologia 52:2079-86. 2009
    ..Our objective was to study the association of directly measured visceral and subcutaneous adipose tissue (VAT, SAT), insulin sensitivity (S (I)) and the acute insulin response (AIR) with incident type 2 diabetes...
  13. ncbi Defibrase, a purified fibrinolytic protease from snake venom in acute myocardial infarction
    D X Huang
    Department of Cardiology, P L A General Hospital, Beijing, P R China
    Acta Cardiol 47:445-58. 1992
    ..v. defibrase thrombolysis, 6 were shown to have patent IRAs. Of the 16 pts who underwent coronary arteriography two weeks after the i.v...
  14. ncbi Insulin resistance and hypertension: the Insulin Resistance Atherosclerosis study
    Mohammed F Saad
    Division of Clinical Epidemiology, Department of Medicine, UCLA Medical School, 924 Westwood Blvd, Suite 335 Mail Box 15, Los Angeles, Calif 90024, USA
    Hypertension 43:1324-31. 2004
    ..505 Hispanics (H), and 413 African Americans (AA) who participated in the Insulin Resistance Atherosclerosis Study (IRAS)...
  15. ncbi Human epidermal Langerhans cells express the tight junction protein claudin-1 and are present in human genetic claudin-1 deficiency (NISCH syndrome)
    Simone C Zimmerli
    Division of Immunology and Allergy, Department of Internal Medicine, Geneva University Hospitals and Medical School, Geneva, Switzerland
    Exp Dermatol 17:20-3. 2008
    ..Our findings do not exclude a role of this TJ molecule once Langerhans cells have left the epidermis for draining lymph nodes...
  16. ncbi Microalbuminuria and carotid artery intima-media thickness in nondiabetic and NIDDM subjects. The Insulin Resistance Atherosclerosis Study (IRAS)
    L Mykkanen
    Department of Medicine, University of Texas Health Science Center at San Antonio 78284 7873, USA
    Stroke 28:1710-6. 1997
    ..We investigated the relationship between microalbuminuria and carotid artery IMT in 991 nondiabetic and 450 NIDDM subjects aged 40 to 69 years...
  17. ncbi Insulin secretion, obesity, and potential behavioral influences: results from the Insulin Resistance Atherosclerosis Study (IRAS)
    E J Mayer-Davis
    School of Public Health, Department of Epidemiology and Biostatistics, University of South Carolina, Columbia, SC 29208, USA
    Diabetes Metab Res Rev 17:137-45. 2001
    ..This work was conducted to evaluate associations of insulin secretion with overall and central obesity, dietary fats, physical activity, and alcohol...
  18. ncbi Utility of a surrogate measure of insulin resistance in American Indians: the Strong Heart Study
    Helaine E Resnick
    MedStar Research Institute, Washington, DC, USA
    Ethn Dis 12:523-9. 2002
    ..assessment (HOMA) model; (2) compare insulin sensitivity in a sample of diabetic and non-diabetic Al in the Strong Heart Study (SHS) with that of White, Black, and Hispanic Americans in the Insulin Resistance Atherosclerosis Study (IRAS).
  19. ncbi Association of protein tyrosine phosphatase 1B gene polymorphisms with measures of glucose homeostasis in Hispanic Americans: the insulin resistance atherosclerosis study (IRAS) family study
    Nicholette D Palmer
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Diabetes 53:3013-9. 2004
    ..001) fasting glucose, respectively, in the IRASFS. This comprehensive genetic analysis of PTPN1 reveals significant association with metabolic traits consistent with the proposed in vivo role for the PTP-1B protein...
  20. ncbi Cosegregation of albuminuria and blood pressure: the Insulin Resistance Atherosclerosis (IRAS) family study
    Xiuqing Guo
    Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Am J Hypertens 18:823-7. 2005
    ..Our aim in this study was to examine the familial aggregation of albuminuria and its phenotypic, genetic, and environmental correlations with BP in nondiabetic individuals of Hispanic (HA) and African American (AA) ethnicity...
  21. ncbi Association of proopiomelanocortin gene polymorphisms with obesity in the IRAS family study
    Beth S Sutton
    Department of Biochemistry, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Obes Res 13:1491-8. 2005
    ..These results support the hypothesis that POMC contributes genetically to the development of obesity...
  22. pmc Association of the Kir6.2 E23K variant with reduced acute insulin response in African-Americans
    Nicholette D Palmer
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Clin Endocrinol Metab 93:4979-83. 2008
    ..2 and SUR1 are expressed in a broad range of tissues, and no contemporary studies have addressed the physiological impact of variants in Hispanic-Americans and African-Americans carefully phenotyped for components of glucose homeostasis...
  23. pmc Genome-wide association study and follow-up analysis of adiposity traits in Hispanic Americans: the IRAS Family Study
    Jill M Norris
    Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora, Colorado, USA
    Obesity (Silver Spring) 17:1932-41. 2009
    ..Several candidate loci, including RGS6 and NGEF, are associated with CT-derived adipose fat measures in Hispanic Americans in a three-stage genetic association study...
  24. pmc Sleep duration and five-year abdominal fat accumulation in a minority cohort: the IRAS family study
    Kristen G Hairston
    Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Sleep 33:289-95. 2010
    ..To study 5-year change in computed tomography (CT)-derived visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) associated with sleep duration in 2 minority groups...
  25. ncbi Major racial differences in coronary constrictor response between japanese and caucasians with recent myocardial infarction
    C Pristipino
    Universita Cattolica del S Cuore, Rome, Italy
    Circulation 101:1102-8. 2000
    ..Japanese have a higher incidence of variant angina than Caucasian patients, but racial differences in vasomotor reactivity early after AMI are controversial...
  26. ncbi High-resolution experimental phases for tryptophanyl-tRNA synthetase (TrpRS) complexed with tryptophanyl-5'AMP
    P Retailleau
    Department of Biochemistry and Biophysics, CB 7260, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Acta Crystallogr D Biol Crystallogr 57:1595-608. 2001
    ..densities for, respectively, peak-wavelength SAD data from four different crystals, MAD data and their M(S)IRAS combinations with native data...
  27. ncbi Protein adsorption on mixtures of hydroxyl- and methyl-terminated alkanethiols self-assembled monolayers
    Ma Cristina L Martins
    Instituto de Engenharia Biomedica, Laboratorio de Biomateriais, and Departmento de Engenharia Metalúrgica e Materias, Universidade do Porto, Porto, Portugal
    J Biomed Mater Res A 67:158-71. 2003
    ..spectroscopy, water contact angles, and Fourier transform infrared reflection absorption spectroscopy (IRAS)...
  28. ncbi Specific reactivity of step sites towards CO adsorption and oxidation on platinum single crystals vicinal to Pt(111)
    Qing Song Chen
    Institute of Electrochemistry, University of Alicante, E 03080 Alicante, Spain
    Phys Chem Chem Phys 12:11407-16. 2010
    ..This was confirmed by in situ infrared reflection-absorption spectroscopy (IRAS) studies, showing that the (110) step sites are dominated by atop CO while bridged bonded CO are prevalent on (100) ..
  29. doi Intercalibration of infrared channels of polar-orbiting IRAS/FY-3A with AIRS/Aqua data
    Geng Ming Jiang
    Key Laboratory of Wave Scattering and Remote Sensing Information Ministry of Education, Fudan University, Shanghai 200433, PR China
    Opt Express 18:3358-63. 2010
    ..47 microm), 9 (11.11 microm) and 19 (3.98 microm) of the InfraRed Atmospheric Sounder (IRAS) aboard the Chinese second generation polar-orbiting meteorological satellite FengYun 3A (FY-3A) with high spectral ..
  30. ncbi Evaluation for an observation effect in a prospective cohort study of oral health outcomes
    G H Gilbert
    Claude D Pepper Center for Research on Oral Health in Aging, College of Dentistry, University of Florida, Gainesville 32610 0416, USA
    Community Dent Oral Epidemiol 26:233-40. 1998
    ..their typical approach to dental care as stated at baseline: consistent regular attenders (CRAs); inconsistent regular attenders (IRAs); consistent problem-oriented attenders (CPOAs); and inconsistent problem-oriented attenders (IPOAs).
  31. ncbi Impaired glucose tolerance, type 2 diabetes, and carotid wall thickness: the Insulin Resistance Atherosclerosis Study
    L E Wagenknecht
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Diabetes Care 21:1812-8. 1998
    ..To assess whether people with impaired glucose tolerance (IGT) exhibit an increased risk of atherosclerosis as measured by the thickness of the carotid artery...
  32. ncbi Constraints on galaxy bias, matter density, and primordial non-Gaussianity from the PSCz galaxy redshift survey
    H A Feldman
    Department of Physics and Astronomy, University of Kansas, Lawrence 66045, USA
    Phys Rev Lett 86:1434-7. 2001
    We compute the bispectrum for the IRAS PSCz catalog and find that the galaxy distribution displays the characteristic signature of gravity. Assuming Gaussian initial conditions, we obtain galaxy biasing parameters 1/b(1) = 1.20(+0.18)(-0...
  33. ncbi The circumstellar environment of IRAS 05338-0624
    J P McMullin
    Astronomy Dept, University of Maryland, College Park 20742, USA
    Astrophys J 437:305-16. 1994
    ..and 60" resolution are used to characterize the structure and chemistry of the gas around the young, embedded star, IRAS 05338-0624...
  34. ncbi Isocyanate formation in the catalytic reaction of CO + NO on Pd(111): an in situ infrared spectroscopic study at elevated pressures
    Emrah Ozensoy
    Department of Chemistry, Texas A and M University, P O Box 30012, College Station, Texas 77842 3012, USA
    J Am Chem Soc 124:8524-5. 2002
    ..at pressures up to 240 mbar using in situ polarization modulation infrared reflection absorption spectroscopy (PM-IRAS)...
  35. ncbi Factor analysis of metabolic syndrome using directly measured insulin sensitivity: The Insulin Resistance Atherosclerosis Study
    Anthony J G Hanley
    Division of Clinical Epidemiology, University of Texas Health Sciences Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Diabetes 51:2642-7. 2002
    ..variables using data from 1,087 nondiabetic participants in the Insulin Resistance Atherosclerosis Study (IRAS)...
  36. ncbi Whole-grain intake and insulin sensitivity: the Insulin Resistance Atherosclerosis Study
    Angela D Liese
    Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, 29208, USA
    Am J Clin Nutr 78:965-71. 2003
    ..Increased intake of whole-grain foods has been related to a reduced risk of developing diabetes and heart disease. One underlying pathway for this relation may be increased insulin sensitivity...
  37. ncbi Relevance of imidazoline receptors and agmatine to psychiatry: a decade of progress
    A Halaris
    University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Ann N Y Acad Sci 1009:1-20. 2003
    ..Attempts at exploring the molecular nature of the I(1) protein have led to the cloning of a protein, IRAS. Based on transfection studies, IRAS seems to be involved in neuronal plasticity events...
  38. ncbi Cell signaling by imidazoline-1 receptor candidate, IRAS, and the nischarin homologue
    J E Piletz
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Ann N Y Acad Sci 1009:392-9. 2003
    ..b>Nischarin is the mouse homologue of IRAS...
  39. ncbi Identification of quantitative trait loci for glucose homeostasis: the Insulin Resistance Atherosclerosis Study (IRAS) Family Study
    Stephen S Rich
    Department of Public Health Sciences, Wake Forest University School of Medicine, 3rd Floor, MRI Center, Winston Salem, NC 27157, USA
    Diabetes 53:1866-75. 2004
    ..subjects has been carried out in African-American (n = 21) and Hispanic (n = 45) extended families as part of the IRAS Family Study...
  40. ncbi The effect of the particle size on the kinetics of CO electrooxidation on high surface area Pt catalysts
    Matthias Arenz
    Materials Science Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
    J Am Chem Soc 127:6819-29. 2005
    Using high-resolution transmission electron microscopy (TEM), infrared reflection-absorption spectroscopy (IRAS), and electrochemical (EC) measurements, platinum nanoparticles ranging in size from 1 to 30 nm are characterized and their ..
  41. ncbi The impact of pedigree structure on heritability estimates for pulse pressure in three studies
    Fang Chi Hsu
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Hum Hered 60:63-72. 2005
    ..of PP in three studies, the Diabetes Heart Study (DHS), the Insulin Resistance Atherosclerosis Family Study (IRAS FS), and the NHLBI Family Heart Study (FHS), to estimate the residual heritability after inclusion of a common set ..
  42. ncbi Imidazoline receptors, novel agents and therapeutic potential
    G A Head
    P O Box 6492, St Kilda Rd Central, Melbourne, Victoria 8008, Australia
    Cardiovasc Hematol Agents Med Chem 4:17-32. 2006
    ..Interestingly, an I(1)- receptor candidate has been cloned (IRAS, imidazoline receptor antisera selected) which is a homologue of the mouse cell adhesion integrin binding protein Nischarin...
  43. ncbi Vibrational properties of CO at the Pt(111)-solution interface: the anomalous Stark-tuning slope
    V Stamenkovic
    Materials Science Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    J Phys Chem B 109:678-80. 2005
    ..5 mV/s) and IRAS spectra (one spectrum for every 1 mV)...
  44. ncbi Status of mature and old-growth forests in the Pacific Northwest
    James R Strittholt
    Conservation Biology Institute, 260 SW Madison, Suite 106, Corvallis, OR 97333, USA
    Conserv Biol 20:363-74. 2006
    ..afforded to old and mature conifer forests if late-successional reserves (LSRs) and inventoried roadless areas (IRAs) were fully protected, and (4) review management options to achieve greater protection of older forests...
  45. pmc Association of TCF7L2 gene polymorphisms with reduced acute insulin response in Hispanic Americans
    Nicholette D Palmer
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Clin Endocrinol Metab 93:304-9. 2008
    ..Genetic variation at the transcription factor 7-like 2 locus has been linked to type 2 diabetes in predominantly European-derived populations. The biological basis of these associations remains to be determined...
  46. ncbi Relationship of admission haematological indices with infarct-related artery patency in patients with acute ST-segment elevation myocardial infarction treated with primary angioplasty
    Orhan Maden
    Cardiology Department, Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey
    Coron Artery Dis 18:639-44. 2007
    ..We aimed to evaluate the value of admission MPV and WBC-C for the prediction of IRA patency, in patients with acute STEMI treated with primary percutaneous coronary intervention...
  47. doi Cross Burg entropy maximization and its application to ringing suppression in image reconstruction
    Y Cao
    KLA Tencor Corp, San Jose, CA 95134, USA
    IEEE Trans Image Process 8:286-92. 1999
    ..Its application to infrared astronomical satellite (IRAS) data shows reduced ringing around point sources, compared to the EM (Richardson-Lucy) algorithm.
  48. doi Methanol oxidation on a Pt(111)-OH/O surface
    Akiyoshi Kuzume
    Department of Chemistry, Faculty of Science and Technology, Keio University, 3 14 1 Hiyoshi, Kohoku Ku, Yokohama, 223 8522, Japan
    Phys Chem Chem Phys 10:2175-9. 2008
    ..hydroxylated Pt (Pt(111)-OH) surface has been investigated by means of infrared reflection absorption spectroscopy (IRAS) in ultra-high vacuum (UHV) and in acidic solution...
  49. pmc Visceral fat and prevalence of hypertension among African Americans and Hispanic Americans: findings from the IRAS family study
    Capri G Foy
    Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Am J Hypertens 21:910-6. 2008
    ..of overall adiposity, and prevalent hypertension among adults enrolled in the Insulin Resistance Atherosclerosis (IRAS) Family Study. We also examined the role of insulin sensitivity (S(I)) upon hypertension...
  50. ncbi [Functional genome analysis investigating resistance to respiratory tract disease in a porcine Actinobacillus pleuropneumoniae infection model]
    T Rehm
    Zentrum für Infektionsmedizin, Institut für Mikrobiologie der Stiftung Tierärztliche Hochschule Hannover
    Dtsch Tierarztl Wochenschr 115:260-4. 2008
    Here we present the work of the multidisciplinary consortium IRAS (Development of Genetic Markers for Immune Defence and Resistance in the Porcine Respiratory Tract) which includes different commercial and research institutions and was ..
  51. pmc Lack of benefit from percutaneous intervention of persistently occluded infarct arteries after the acute phase of myocardial infarction is time independent: insights from Occluded Artery Trial
    Venu Menon
    Division of Cardiology, F 15, 9500 Euclid Avenue, Cleveland Clinic, Cleveland, OH 4419, USA
    Eur Heart J 30:183-91. 2009
    ..and class IV heart failure (congestive heart failure) in stable post-MI patients with late occluded infarct-related arteries (IRAs). We evaluated the potential for selective benefit with PCI over MED for patients enrolled early in OAT.
  52. pmc INSIG2 SNPs associated with obesity and glucose homeostasis traits in Hispanics: the IRAS Family Study
    Matthew E Talbert
    Program in Molecular Medicine and Translational Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Obesity (Silver Spring) 17:1554-62. 2009
    ..Trending association after multiple comparisons adjustment remains suggestive of a role for genetic variation of INSIG2 in obesity, but these results require validation...
  53. pmc A genome-wide association scan for acute insulin response to glucose in Hispanic-Americans: the Insulin Resistance Atherosclerosis Family Study (IRAS FS)
    S S Rich
    Center for Public Health Genomics, University of Virginia, 6111 West Complex, Charlottesville, VA 22908, USA
    Diabetologia 52:1326-33. 2009
    ..in the human genome that are associated with the acute insulin response to glucose (AIRg), an important predictor of type 2 diabetes, in Hispanic-American participants from the Insulin Resistance Atherosclerosis Family Study (IRAS FS).
  54. pmc Prospective association between fasting NEFA and type 2 diabetes: impact of post-load glucose
    D Il'yasova
    Department of Community and Family Medicine, Prevention Research Division, Duke University Medical Center, Box 2949, Durham, NC, 27710, USA
    Diabetologia 53:866-74. 2010
    ..To examine this assumption, we used cohort data from the Insulin Resistance Atherosclerosis Study (IRAS).
  55. ncbi Enhanced stability of gold clusters supported on hydroxylated MgO(001) surfaces
    Matthew A Brown
    Department of Chemical Physics, Fritz Haber Institut der Max Planck Gesellschaft, D 14195 Berlin, Germany
    J Am Chem Soc 132:4064-5. 2010
    ..A combination of different spectroscopic techniques (TDS, XPS, IRAS) allows to establish a correlation between the degree of surface hydroxylation and the stability of gold atoms and ..
  56. doi Active surfaces for CO oxidation on palladium in the hyperactive state
    Mingshu Chen
    State Key Laboratory of Physical Chemistry of Solid Surfaces, Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian, China
    Langmuir 26:18113-8. 2010
    ..at the hyperactive state for palladium were characterized using infrared reflection absorption spectroscopy (IRAS, 450-4000 cm(-1)) under the realistic catalytic reaction condition...
  57. pmc RGS6 variants are associated with dietary fat intake in Hispanics: the IRAS Family Study
    Scott P Sibbel
    Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora, Colorado, USA
    Obesity (Silver Spring) 19:1433-8. 2011
    Recently, a genome-wide association scan was completed in the IRAS (Insulin Resistance Atherosclerosis Study) Family Study (IRASFS) Hispanic-American cohort...
  58. doi Imidazoline receptor antisera-selected/Nischarin regulates the effect of agmatine on the development of morphine dependence
    Fei Li
    Beijing Institute of Pharmacology and Toxicology, China
    Addict Biol 17:392-408. 2012
    ..the function of I1 imidazoline receptor and its candidate protein imidazoline receptor antisera-selected (IRAS)/Nischarin in morphine dependence as well as in the effect of agmatine inhibiting morphine dependence by pharmacological ..
  59. doi CO oxidation over ruthenium: identification of the catalytically active phases at near-atmospheric pressures
    Feng Gao
    Chemical and Materials Sciences Division, Pacific Northwest National Laboratory, P O Box 999, Richland, WA 99352, USA
    Phys Chem Chem Phys 14:6688-97. 2012
    ..Reaction kinetics, coupled with in situ polarization modulation infrared reflection absorption spectroscopy (PM-IRAS) and post-reaction Auger electron spectroscopy (AES) measurements, were used to identify the catalytically relevant ..
  60. doi An "I" on cardiac hypertrophic remodelling: imidazoline receptors and heart disease
    Suhayla Mukaddam-Daher
    Centre Hospitalier de L Universite de Montreal Research Center, and Departments of Medicine and Pharmacology, Universite de Montreal, Montreal, Quebec, Canada
    Can J Cardiol 28:590-8. 2012
    ..The actions are selectively mediated by imidazoline type-1 receptor (I(1)-receptor, also named nischarin), nonadrenergic neurotransmitter receptors mainly found in the brainstem medulla...
  61. ncbi Preparation and characterization of ultrathin [Ru(CO)3Cl2]2 and [BMIM][Tf2N] films on Al2O3/NiAl(110) under UHV conditions
    Marek Sobota
    Lehrstuhl fur Physikalische Chemie II, Friedrich Alexander Universitat Erlangen Nurnberg, Egerlandstrasse 3, D 91058 Erlangen, Germany
    Phys Chem Chem Phys 14:10603-12. 2012
    ..Growth, surface interactions, and mutual interactions in the thin films are studied with IRAS in combination with density functional (DFT) calculations...
  62. doi Aberrant genes promoter methylation in neural crest-derived tumors
    Annamaria la Torre
    Laboratory of Oncology, IRCCS Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Foggia, Italy
    Int J Biol Markers 27:e389-94. 2012
    ..MCAM methylation levels were significantly higher in lung carcinoids tumors (p=0.001), suggesting that this alteration may represent a molecular biomarker in this tumor type...
  63. pmc Prooncogenic factors miR-23b and miR-27b are regulated by Her2/Neu, EGF, and TNF-α in breast cancer
    Lianjin Jin
    Department of Biochemistry and Molecular Biology and Stanley S Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Cancer Res 73:2884-96. 2013
    ..We found that engineered knockdown of miR-23b and miR-27b substantially repressed breast cancer growth. Nischarin (NISCH) expression was augmented by knockdown of miR-23b as well as miR-27b...
  64. doi A regulatory governance perspective on Health Technology Assessment (HTA) in Sweden
    Sara Mehmood Birchall Shah
    LSE Health, Department of Social Policy, London School of Economics and Political Science, Houghton Street, London WC2A 2AE, United Kingdom Electronic address
    Health Policy 116:27-36. 2014
    Independent regulatory agencies (IRAs) for Health Technology Assessment (HTA) are a key means by which national governments have responded to the challenge of ensuring equitable public access to a new range of medicines and treatment ..
  65. doi Interrater agreement statistics with skewed data: evaluation of alternatives to Cohen's kappa
    Shu Xu
    Family Translational Research Group
    J Consult Clin Psychol 82:1219-27. 2014
    In this study, we aimed to evaluate interrater agreement statistics (IRAS) for use in research on low base rate clinical diagnoses or observed behaviors...
  66. doi [The role of primary care in the prevention and control of healthcare associated infections]
    Maria Clara Padoveze
    Department of Public Health Nursing, School of Nursing, University of Sao Paulo, Sao Paulo, SP, Brazil
    Rev Esc Enferm USP 48:1137-44. 2014
    ....
  67. pmc Expression of integrin-binding protein Nischarin in metastatic breast cancer
    Jie Chen
    Department of Breast Surgery, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P R China
    Mol Med Rep 12:77-82. 2015
    The present study aimed to investigate the expression of Nischarin protein in primary breast cancer (PBC), and to evaluate its role in tumor metastasis...
  68. doi Prediction of type 1 diabetes in Sardinian schoolchildren using islet cell autoantibodies: 10-year follow-up of the Sardinian schoolchildren type 1 diabetes prediction study
    Fernanda Velluzzi
    Department of Medical Sciences Mario Aresu, University of Cagliari, AOU, SS 554, Monserrato, Cagliari, Italy
    Acta Diabetol 53:73-9. 2016
    ..from the Mediterranean island of Sardinia ideal to define the predictive power of islet-related autoantibodies (IRAs): glutamic acid decarboxylase antibodies (GADA), tyrosine phosphatase-like antibodies (IA-2A), islet cell ..
  69. pmc A Comprehensive Analysis of Common and Rare Variants to Identify Adiposity Loci in Hispanic Americans: The IRAS Family Study (IRASFS)
    Chuan Gao
    Molecular Genetics and Genomics Program, Wake Forest School of Medicine, Winston Salem, North Carolina, United States of America
    PLoS ONE 10:e0134649. 2015
    ..While replication efforts were inconclusive, when taken together with the known biology, IDH1 and ZGRF1 warrant further evaluation. ..
  70. doi Functionalized Porphyrins on an Atomically Defined Oxide Surface: Anchoring and Coverage-Dependent Reorientation of MCTPP on Co3O4(111)
    Kristin Werner
    Lehrstuhl fur Physikalische Chemie II, Lehrstuhl fur Theoretische Chemie, and Erlangen Catalysis Resource Center and Interdisciplinary Center for Interface Controlled Processes, Friedrich Alexander Universitat Erlangen Nurnberg, Egerlandstraße 3, D 91058 Erlangen, Germany
    J Phys Chem Lett 7:555-60. 2016
    ..Using time-resolved infrared reflection absorption spectroscopy (TR-IRAS), we show that 2HTPP adsorbs molecularly in a flat-lying orientation, whereas MCTPP binds to the surface via ..
  71. doi Surface etching, chemical modification and characterization of silicon nitride and silicon oxide--selective functionalization of Si3N4 and SiO2
    Li Hong Liu
    Department of Materials Science and Engineering, University of Texas at Dallas, Richardson, TX 75080, USA
    J Phys Condens Matter 28:094014. 2016
    ..conditions and studied the chemical nature of the resulting Si3N4 surfaces using infrared absorption spectroscopy (IRAS), x-ray photoelectron spectroscopy (XPS), low energy ion scattering (LEIS), and contact angle measurements...
  72. pmc Branched-Chain Amino Acids and Insulin Metabolism: The Insulin Resistance Atherosclerosis Study (IRAS)
    C Christine Lee
    Department of Nutritional Sciences, University of Toronto, Toronto, ON, Canada
    Diabetes Care 39:582-8. 2016
    ..We investigated the associations of BCAAs with insulin sensitivity (SI), acute insulin response (AIR), and metabolic clearance of insulin (MCRI) in a multiethnic cohort...
  73. doi Tooth Loss in Problem-oriented, Irregular, and Regular Attenders at Dental Offices
    Koichi Yoshino
    Department of Epidemiology and Public Health, Tokyo Dental College
    Bull Tokyo Dent Coll 57:11-9. 2016
    ..of this retrospective study was to compare number of teeth lost among regular attenders (RAs), irregular attenders (IRAs), and problem-oriented attenders (POAs) at dental offices over a 10-yr observation period...
  74. pmc Surface Spectroscopy on UHV-Grown and Technological Ni-ZrO2 Reforming Catalysts: From UHV to Operando Conditions
    Kresimir Anic
    Institute of Materials Chemistry, Technische Universitat Wien, Getreidemarkt 9 BC 01, 1060 Vienna, Austria
    Top Catal 59:1614-1627. 2016
    ..examine the atomic (HRTEM/XRD/LEED) and electronic (XPS) structure, as well as the adsorption properties (FTIR/PM-IRAS), with emphasis on in situ/operando studies under atmospheric pressure conditions...
  75. ncbi CoMFA and CoMSIA investigations revealing novel insights into the binding modes of dopamine D3 receptor agonists
    Frank Boeckler
    Department of Medicinal Chemistry, Emil Fischer Center, Friedrich Alexander University, Schuhstrasse 19, D 91052 Erlangen, Germany
    J Med Chem 48:2493-508. 2005
    ..726 and 0.590, respectively, when a newly invented program application (IRAS) controlling the alignment selection proved to be useful...
  76. ncbi Structure and desorption energetics of ultrathin D2O ice overlayers on serine- and serinephosphate-terminated self-assembled monolayers
    Mattias Ostblom
    Division of Molecular Physics, Department of Physics, Chemistry, and Biology, Linkoping University, SE 581 83 Linkoping, Sweden
    J Phys Chem B 110:1695-700. 2006
    ..SAMs at approximately 85 K in ultrahigh vacuum and characterized with infrared reflection absorption spectroscopy (IRAS). Reflection absorption (RA) spectra obtained at sub-monolayer D2O coverage reveal that surface modes, e.g...
  77. ncbi Genetic mapping of disposition index and acute insulin response loci on chromosome 11q. The Insulin Resistance Atherosclerosis Study (IRAS) Family Study
    Nicholette D Palmer
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Diabetes 55:911-8. 2006
    ..These detailed genetic analyses provide strong evidence of a DI locus on 11q in African-American pedigrees, with additional suggestive evidence of independent AIR loci in the same region...
  78. pmc The association of inflammatory and fibrinolytic proteins with 5 year change in insulin clearance: the Insulin Resistance Atherosclerosis Study (IRAS)
    C C Lee
    Department of Nutritional Sciences, Fitzgerald Building, University of Toronto, 150 College St, Toronto, ON, Canada M5S 3E2
    Diabetologia 56:112-20. 2013
    ..We examined the association between plasminogen activator inhibitor (PAI)-1, C-reactive protein (CRP), TNF-α, leptin and fibrinogen and the progression of metabolic clearance rate of insulin (MCRI) over time...
  79. doi Effects of O2 pressure on the oxidation of VO(x)/Pt(111)
    Zhenyan Tang
    State Key Laboratory of Physical Chemistry of Solid Surfaces, Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian, China
    Phys Chem Chem Phys 15:12124-31. 2013
    ..spectroscopy (LEIS), Auger electron spectroscopy (AES), and in situ infrared reflection absorption spectroscopy (IRAS)...
  80. ncbi Effect of postmortem delay on imidazoline receptor-binding proteins in human and mouse brain
    John K Ma
    Department of Psychiatry, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Ann N Y Acad Sci 1009:341-6. 2003
    ..immunoreactive bands of similar size have been suggested to be breakdown products of the 170-kD protein known as IRAS (putative full-length I(1) receptor)...
  81. ncbi Structural characterization of microcontact printed arrays of hexa(ethylene glycol)-terminated alkanethiols on gold
    Ye Zhou
    S SENCE and Division of Sensor Science and Molecular Physics, Linkoping University, S 581 83 Linkoping, Sweden
    Langmuir 20:6206-15. 2004
    ..Microwetting, contact angle goniometry, imaging null ellipsometry, and infrared reflection-absorption spectroscopy (IRAS) are used to characterize the printed EG6 layers, and the quality of these layers in terms of layer thickness and ..
  82. ncbi Photoinduced surface dynamics of CO adsorbed on a platinum electrode
    Hidenori Noguchi
    J Phys Chem B 110:15055-8. 2006
    ..with potential by approximately 33 cm(-1)/V, as previously found in an infrared reflection absorption spectroscopy (IRAS) study...
  83. ncbi Modulation of agmatine on calcium signal in morphine-dependent CHO cells by activation of IRAS, a candidate for imidazoline I1 receptor
    Ning Wu
    Beijing Institute of Pharmacology and Toxicology, 27th Taiping Road, Beijing 100850, China
    Eur J Pharmacol 548:21-8. 2006
    The present study investigated the effects of agmatine action on imidazoline I1 receptor antisera-selected protein (IRAS), a candidate for imidazoline I1 receptor, on prolonged morphine-induced adaptations of calcium signal and long-..
  84. doi A simulation framework for estimating wall stress distribution of abdominal aortic aneurysm
    Jing Qin
    Department of Mechanical Engineering, National University of Singapore
    Conf Proc IEEE Eng Med Biol Soc 2011:900-3. 2011
    ..of non-stented/stented AAA based on fluid-structure interaction, which is utilized in a surgical simulation system (IRAS). The 3D geometric model of AAA is reconstructed from computed tomography angiographic (CTA) images...
  85. ncbi Interaction of CO and deuterium with bimetallic, monolayer Pt-island/film covered Ru(0001) surfaces
    H Hartmann
    Institute of Surface Chemistry and Catalysis, Ulm University, D 89069 Ulm, Germany
    Phys Chem Chem Phys 14:10919-34. 2012
    ..Additionally, the adsorption of CO was investigated by infrared reflection absorption spectroscopy (IRAS)...
  86. doi Infrared spectroelectrochemical study of dissociation and oxidation of methanol at a palladium electrode in alkaline solution
    Yao Yue Yang
    Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai 200433, China
    Langmuir 29:1709-16. 2013
    ..The former (ATR-SEIRAS) has a higher sensitivity of detecting surface species, and the latter (IRAS) can easily detect dissolved species trapped in a thin-layer-structured electrolyte...
  87. doi Site-specific and covalent attachment of his-tagged proteins by chelation assisted photoimmobilization: a strategy for microarraying of protein ligands
    Emma M Ericsson
    Division of Molecular Physics, Division of Organic Chemistry, and Division of Applied Physics Department of Physics, Chemistry and Biology, Linkoping University, SE 581 83 Linkoping, Sweden
    Langmuir 29:11687-94. 2013
    ..SAMs) were prepared on gold and thoroughly characterized by infrared reflection absorption spectroscopy (IRAS), ellipsometry, and contact angle goniometry...
  88. ncbi Accuracy of IRAS GT interferometer and potential acuity meter prediction of visual acuity after phacoemulsification: prospective comparative study
    Cécile Le Sage
    Service d Ophtalmologie, CMC Gui de Chauliac, Montpellier, France
    J Cataract Refract Surg 28:131-8. 2002
    ..To assess and compare the accuracy of 2 methods of predicting visual acuity after phacoemulsification...
  89. ncbi Genetic mapping of a 17q chromosomal region linked to obesity phenotypes in the IRAS family study
    B S Sutton
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Int J Obes (Lond) 30:1433-41. 2006
    ..In the IRAS Family Study a genomewide scan was performed on 1425 individuals of Hispanic descent (90 extended pedigree families)..
  90. ncbi On the structure and desorption dynamics of DNA bases adsorbed on gold: a temperature-programmed study
    Mattias Ostblom
    Division of Molecular Physics, Department of Physics, Chemistry and Biology, Linkoping University, S 581 83 Linkoping, Sweden
    J Phys Chem B 109:15150-60. 2005
    ..thin films are studied using temperature-programmed desorption-infrared reflection absorption spectroscopy (TPD-IRAS) and temperature-programmed desorption-mass spectroscopy (TPD-MS)...
  91. pmc Fish consumption, insulin sensitivity and beta-cell function in the Insulin Resistance Atherosclerosis Study (IRAS)
    C Lee
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    Nutr Metab Cardiovasc Dis 23:829-35. 2013
    ..Therefore, we examined the association of fish consumption with measures of insulin sensitivity and beta-cell function in a multi-ethnic population...
  92. ncbi Duration of diabetes and carotid wall thickness. The Insulin Resistance Atherosclerosis Study (IRAS)
    L E Wagenknecht
    Department of Public Health Sciences, Bowman Gray School of Medicine of Wake Forest University, Winston Salem, NC 27157, USA
    Stroke 28:999-1005. 1997
    ..Diabetes is a major risk factor for morbidity and mortality from cardiovascular disease. However, the role of the primary metabolic abnormality of diabetes (chronic hyperglycemia) in this disease process has not been fully elucidated...
  93. ncbi Ability of alternative indices of insulin sensitivity to predict cardiovascular risk: comparison with the "minimal model". Insulin Resistance Atherosclerosis Study (IRAS) Investigators
    G Howard
    Department of Public Health Sciences, Bowman Gray School of Medicine of Wake Forest University, Winston Salem, NC, USA
    Ann Epidemiol 8:358-69. 1998
    ..This report evaluates previously described alternative indices of insulin sensitivity with the goal of identifying a reliable, but logistically simpler, alternative...
  94. ncbi Relative contribution of insulin and its precursors to fibrinogen and PAI-1 in a large population with different states of glucose tolerance. The Insulin Resistance Atherosclerosis Study (IRAS)
    A Festa
    Department of Medicine, Division of Clinical Epidemiology, University of Texas Health Science Center at San Antonio, TX 78284 7873, USA
    Arterioscler Thromb Vasc Biol 19:562-8. 1999
    ..These findings may have important clinical implications in the risk assessment and prevention of macrovascular disease, not only in patients with overt diabetes but also in nondiabetic subjects who are hyperinsulinemic...
  95. ncbi Imidazoline receptor antisera-selected cDNA clone and mRNA distribution
    J E Piletz
    Department of Psychiatry, University of Mississippi Medical Center, Jackson 39216 4505, USA
    Ann N Y Acad Sci 881:1-7. 1999
    A novel cDNA, designated Imidazoline Receptor Antisera-Selected cDNA-1 (iras-1), encodes a 167-kD protein. Two of its predicted peptides (42-43 kD) are immunologically consistent with a previously reported 1(1)-imidazoline binding protein...
  96. ncbi Suppression and enhancement of distortion-product otoacoustic emissions by interference tones above f(2). I. Basic findings in rabbits
    G K Martin
    Department of Otolaryngology M805, University of Miami School of Medicine, P O Box 016960, Miami, FL 33101 6960, USA
    Hear Res 136:105-23. 1999
    The present study measured interference-response areas (IRAs) for distortion-product otoacoustic emissions (DPOAEs) at 2f(1)-f(2), 3f(1)-2f(2), and 2f(2)-f(1)...
  97. ncbi Transforming growth factor-beta1 enhances Ha-ras-induced expression of cyclooxygenase-2 in intestinal epithelial cells via stabilization of mRNA
    H Sheng
    Department of Surgery, The Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Biol Chem 275:6628-35. 2000
    ..RIE-1 cells were transfected with an inducible Ha-Ras(Val12) cDNA and are referred as RIE-iRas cells...
  98. ncbi Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS)
    A Festa
    Department of Medicine, University of Texas Health Science Center at San Antonio, 78228 3900, USA
    Circulation 102:42-7. 2000
    ..Recently, some components of the insulin resistance syndrome (IRS) have been related to inflammatory markers. We hypothesized that insulin insensitivity, as directly measured, may be associated with inflammation in nondiabetic subjects...
  99. ncbi Plasma and dietary vitamin E in relation to incidence of type 2 diabetes: The Insulin Resistance and Atherosclerosis Study (IRAS)
    Elizabeth J Mayer-Davis
    Department of Epidemiology and Biostatistics, Norman J Arnold School of Public Health, University of South Carolina, Columbia 29208, USA
    Diabetes Care 25:2172-7. 2002
    ..To evaluate the association of vitamin E with incidence of type 2 diabetes and to do so separately among individuals who did and those who did not report regular use of vitamin supplementation...
  100. ncbi Insulin sensitivity and the risk of incident hypertension: insights from the Insulin Resistance Atherosclerosis Study
    David C Goff
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1063, USA
    Diabetes Care 26:805-9. 2003
    ..Previous studies have documented cross-sectional associations between insulin sensitivity (S(I)) and blood pressure or prevalent hypertension. Prospective data have been sparse...
  101. ncbi The intracrine hypothesis and intracellular peptide hormone action
    Richard N Re
    Research Division, Ochsner Clinic Foundation, 99 1514 Jefferson Highway, New Orleans, LA 70121, USA
    Bioessays 25:401-9. 2003
    ..The intracellular/intracrine renin-angiotensin system (iRAS) is reviewed to illustrate the intracrine analogue of a well-established physiological system...

Research Grants47

  1. KRISTEN GILL HAIRSTON; Fiscal Year: 2014
    ..sets and new laboratory assays of stored specimens in an NIH-supported longitudinal multi-ethnic cohort study, the IRAS Family Study (R01 HL060944)...
  2. Genetic Determinants of Visceral Adiposity
    Yongmei Liu; Fiscal Year: 2013
    ..Study of Atherosclerosis (MESA, 787 EAs, 411 AAs A), and the Insulin Resistance Atherosclerosis Family Study (IRAS, 600 AAs), will be used to further validate those SNPs (probably 10-15) replicated in FHS or JHS...
  3. Genetic &Epidemiologic Predictors of Glucose Homeostasis Measures in Hispanics
    Richard M Watanabe; Fiscal Year: 2013
    ..In the IRAS Family Study (funded for two five-year cycles by NHLBI), we have recruited a large Hispanic cohort and obtained ..
  4. Intergration of Functional and Molecular Genetics to Identify Diabetes Genes
    Donald W Bowden; Fiscal Year: 2012
    ..genetic evidence for genes contributing to acute insulin response and disposition index on chromosome 11q in the IRAS Family Study, but to date we have no complementary functional biology studies...
  5. Insulin Resistance and Adenomas of the Colorectum
    Mohammed Saad; Fiscal Year: 2003
    ..The Insulin Resistance and Atherosclerosis Study (IRAS) is a cohort study supported by the National Heart Lung and Blood Institute...
  6. Insulin Resistance and Adenomas of the Colorectum
    Tim Byers; Fiscal Year: 2003
    ..The Insulin Resistance and Atherosclerosis Study (IRAS) is a cohort study supported by the National Heart Lung and Blood Institute...
  7. Insulin Resistance and Adenomas of the Colorectum
    Theodore Levin; Fiscal Year: 2003
    ..The Insulin Resistance and Atherosclerosis Study (IRAS) is a cohort study supported by the National Heart Lung and Blood Institute...
  8. Hippocampal plasticity in co-morbid diabetes and depression
    LAWRENCE P contact REAGAN; Fiscal Year: 2010
    ..recently developed a novel and innovative lentivirus vector that contains an antisense sequence selective for IR (IRAS) that examines the effects of decreasing IR signaling without affecting these other parameters...
  9. Lawrence P Reagan; Fiscal Year: 2016
    ..leptin and using a lentivirus vector that selectively downregulates hypothalamic insulin receptor expression (hypo-IRAS)...
  10. GLYCEMIA AND RELATED MECHANISMS OF MACROVASCULAR DISEASE
    Lynne Wagenknecht; Fiscal Year: 1999
    ..The proposed study is designed to explore possible mechanisms in the Insulin Resistance Atherosclerosis Study (IRAS) cohort, a NHLBI-funded epidemiologic study...
  11. Electrophysiologic effects of late PCI (OAT-EP)
    Stephen Shorofsky; Fiscal Year: 2005
    ..prospective studies that have evaluated late percutaneous transluminal coronary angioplasty (PTCA) of occluded IRAs after AMI have produced conflicting results...
  12. DIABETES, LIPOPROTEINS AND ACCELERATED VASCULAR DISEASE
    Henry Ginsberg; Fiscal Year: 2000
    ..Pima Indians with NIDDM in the Strong Heart Study, and in Blacks, Whites and Hispanics with IGT and NIDDM in the IRAS study...
  13. SLEEP-DISORDERED BREATHING & THE METABOLIC SYNDROME
    Mohammed Saad; Fiscal Year: 2003
    ..cohort of African American families participating in the Insulin Resistance Atherosclerosis Family Study (IRAS Family Study), an ongoing study funded by NHLBI...
  14. INSULIN RESISTANCE AND ATHEROSCLEROSIS STUDY (IRAS)
    Steven Haffner; Fiscal Year: 1999
    The Insulin Resistance and Atherosclerosis Study (IRAS) is a multicenter study of the relationship between insulin resistance and cardiovascular disease (CVD) and its risk factors in a tri-ethnic (African-American, Hispanic, and non-..
  15. INSULIN RESISTANCE AND ATHEROSCLEROSIS STUDY (IRAS)
    Marian Rewers; Fiscal Year: 1999
    The Insulin Resistance and Atherosclerosis Study (IRAS) is a multicenter study of the relationship between insulin resistance and cardiovascular disease (CVD) and its risk factors in a tri-ethnic (African American, Hispanic, and non-..
  16. INSULIN RESISTANCE AND ATHEROSCLEROSIS STUDY (IRAS)
    Richard Bergman; Fiscal Year: 1999
    The Insulin Resistance and Atherosclerosis Study (IRAS) is a multicenter study of the relationship between insulin resistance and cardiovascular disease (CVD) and its risk factors in a tri-ethnic (African-American, Hispanic, and non-..
  17. INSULIN RESISTANCE AND ATHEROSCLEROSIS STUDY (IRAS)
    Joe Selby; Fiscal Year: 1999
    The Insulin Resistance and Atherosclerosis Study (IRAS) is a multicenter study of the relationship between insulin resistance and cardiovascular disease (CVD) and its risk factors in a tri-ethnic (African-American, Hispanic, and non-..
  18. INSULIN RESISTANCE AND ATHEROSCLEROSIS STUDY (IRAS)
    Lynne Wagenknecht; Fiscal Year: 1999
    The Insulin Resistance and Atherosclerosis Study (IRAS) is a multicenter study of the relationship between insulin resistance and cardiovascular disease (CVD) and its risk factors in a tri-ethnic (African-American, Hispanic, and non-..
  19. INSULIN RESISTANCE AND ATHEROSCLEROSIS STUDY (IRAS)
    Mohammed Saad; Fiscal Year: 1999
    The Insulin Resistance Atherosclerosis Study (IRAS) is a multicenter study of the relationship between insulin resistance and cardiovascular disease (CVD) and its risk factors in a tri-ethnic (African-American, Hispanic, and non-Hispanic ..
  20. Spatial epidemiology of diabetes in the SEARCH for Diabetes in Youth Study
    ANGELA LIESE; Fiscal Year: 2009
    ..This effort may provide novel leads for subsequent etiologic studies of pediatric diabetes and will assist health care planners in identifying geographic areas in particular need of health services resources. ..
  21. GENCAC - North Carolina Field Center
    Lynne Wagenknecht; Fiscal Year: 2004
    ..This application corresponds to the GENCAC clinic submitted by the Wake Forest University School of Medicine as part of the GENCAC genetic epidemiology network. ..
  22. GENETICS OF ADIPOSITY AND GLUCOSE HOMEOSTASIS
    Lynne Wagenknecht; Fiscal Year: 2009
    The IRAS Family Study, initially funded as six linked R01s in 1999, is a multicenter project designed to study the genetic epidemiology of adiposity and glucose homeostasis...
  23. Type 1 Diabetes Genetics Consortium
    Stephen Rich; Fiscal Year: 2007
    ..The Consortium will gain a better understandingof disease mechanisms, with a purpose of altering these mechanisms and pathways in individualsat risk of type 1 diabetes. ..
  24. The role of copy number variants (CNV) in type 1 diabetes
    Stephen Rich; Fiscal Year: 2009
    ..Identification of genetic risk factors for T1D is the first step in risk prediction, intervention and developing disease therapeutics (prevention). ..
  25. Molecular genetics of glucose homeostasis and fat
    Donald Bowden; Fiscal Year: 2009
    In this study we will locate and identify genes contributing to glucose homeostasis and adiposity in the IRAS Family Study...
  26. IRAS FAMILY STUDY--GENETICS OF INSULIN RESISTANCE
    Richard Bergman; Fiscal Year: 2003
    ..The organization of this study will be similar to that of IRAS, with three clinical centers, a coordinating center, a central laboratory and a genetic laboratory...
  27. DPOAE PHENOTYPING OF COCHLEAR FUNCTION
    Glen Martin; Fiscal Year: 2001
    ..The resulting data will be made widely available on the internet in the form of databases and the relevant training manuals. ..
  28. GENE ENVIRONMENT STUDY OF TYPE 2 DIABETES IN FAMILIES
    Jill Norris; Fiscal Year: 2002
    ....
  29. Insulin Resistance and Adenomas of the Colorectum
    RALPH DAGOSTINO; Fiscal Year: 2003
    ..The Insulin Resistance and Atherosclerosis Study (IRAS) is a cohort study supported by the National Heart Lung and Blood Institute...
  30. Genetic contributors to diabetes and dyslipidemia in African Americans
    Michele M Sale; Fiscal Year: 2010
    ..We propose applying this proven strategy to identify new therapeutic targets and allow translation to novel diagnostic, prevention, and treatment strategies for type 2 diabetes. ..
  31. Genetic Influences on Coronary Artery Calcification
    Braxton D Mitchell; Fiscal Year: 2010
    ..This will impact substantially on mortality, quality of life, and health care costs for millions of middle-aged and elderly Americans. ..
  32. Insulin Resistance and Adenomas of the Colorectum
    Steven Haffner; Fiscal Year: 2003
    ..The Insulin Resistance and Atherosclerosis Study (IRAS) is a cohort study supported by the National Heart Lung and Blood Institute...
  33. Epidemiology of cardiovascular disease in diabetes
    Donald Bowden; Fiscal Year: 2004
    ..Evidence for linkage to QTLs influencing CAC and IMT will be pursued in those chromosomal regions showing suggestive evidence for linkage and then performing further analyses to detect associations with these "saturation" markers. ..
  34. Joint Determinants of Bone Density and CVD Calcification
    Braxton Mitchell; Fiscal Year: 2004
    ..Such insights could lead to elucidation of specific genetic pathways that can be exploited in the future for early identification of high-risk individuals, as well as development of new preventive and therapeutic approaches...
  35. Identification of diabetes genes on human chromosome 20
    Donald Bowden; Fiscal Year: 2009
    ..g. insulin resistance, (3-cell function, etc.). Confirmation of association in multiple populations will justify a more detailed molecular genetic analysis similar to that being proposed for PTPN1. ..
  36. Do Free Glucose Test Strips Increase Self-Monitoring?
    Andrew Karter; Fiscal Year: 2003
    ..Proposal strengths also include a longitudinal design, substantial statistical power, low cost data acquisition, and an ethnically diverse population with uniform access to care. ..
  37. QUANTITATIVE STUDIES OF METABOLIC ORGAN DYNAMICS
    Richard Bergman; Fiscal Year: 2005
    ..abstract_text> ..
  38. GENETICS OF ADIPOSITY AND GLUCOSE HOMEOSTASIS
    Jill Norris; Fiscal Year: 2009
    The IRAS Family Study, initially funded as six linked R01s in 1999, is a multicenter project designed to study the genetic epidemiology of adiposity and glucose homeostasis...
  39. METHODS FOR EPIDEMIOLOGIC DATA WITH MISSING VALUES
    RALPH DAGOSTINO; Fiscal Year: 2003
    ..In addition, substantive medical and epidemiological questions will be answered using this new methodology on the applied data sets provided. ..
  40. Ethnic Disparities in Diabetes Complications
    Andrew Karter; Fiscal Year: 2008
    ..abstract_text> ..
  41. GENETICS OF BONE DENSITY IN MEXICAN AMERICANS
    Braxton Mitchell; Fiscal Year: 2008
    ..abstract_text> ..
  42. GENETICS OF ADIPOSITY AND GLUCOSE HOMEOSTASIS
    Carlos Lorenzo; Fiscal Year: 2008
    The IRAS Family Study, initially funded as six linked R01s in 1999, is a multicenter project designed to study the genetic epidemiology of adiposity and glucose homeostasis...
  43. Personal Digital Assistant for Guideline Adherence Trial
    David Goff; Fiscal Year: 2006
    ..Hence, this innovative strategy holds great promise for making a substantial public health impact through the prevention of CVD and through subsequent translation to other important conditions. ..
  44. Educational Disparities in Diabetes Complications
    Andrew Karter; Fiscal Year: 2006
    ..abstract_text> ..
  45. Phenotype-Genotype Interactions and Type 2 Diabetes
    James Meigs; Fiscal Year: 2005
    ..Results will provide a foundation for future laboratory efforts and will increase understanding of phenotype-genotype interactions in diabetes pathogenesis. ..
  46. PHYSIOLOGICAL BASES OF OTOTRAUMATIC INSULT
    Glen Martin; Fiscal Year: 2005
    ..The third hypothesis tests whether susceptibility to hearing loss or the prevention from it is associated with specific molecules in the cochlea. ..