IQGAP2

Summary

Gene Symbol: IQGAP2
Description: IQ motif containing GTPase activating protein 2
Alias: ras GTPase-activating-like protein IQGAP2
Species: human

Top Publications

  1. pmc The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases
    S Brill
    Massachusetts General Hospital Cancer Centre, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Mol Cell Biol 16:4869-78. 1996
  2. ncbi Cloning and characterization of a novel transcript variant of IQGAP2 in human testis
    Hui Wang
    Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210029, P R of China
    DNA Seq 15:319-25. 2004
  3. ncbi IQGAP2 inactivation through aberrant promoter methylation and promotion of invasion in gastric cancer cells
    Shun Hua Jin
    Department of Molecular Oncology, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, Tokyo, Japan
    Int J Cancer 122:1040-6. 2008
  4. ncbi IQGAP2 functions as a GTP-dependent effector protein in thrombin-induced platelet cytoskeletal reorganization
    Valentina A Schmidt
    Department of Medicine and the Program in Genetics, State University of New York, Stony Brook, 11794, USA
    Blood 101:3021-8. 2003
  5. pmc Conserved sequence repeats of IQGAP1 mediate binding to Ezrin
    Jing Liu
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1901 Perdido Street, New Orleans, Louisiana 70112, United States
    J Proteome Res 13:1156-66. 2014
  6. ncbi Hepatocellular carcinoma in IQGAP2-deficient mice and evaluation of IQGAP2 as a potential novel tumor suppressor gene
    V A Schmidt
    State University of New York Stony Brook, Stony Brook, NY
    J Clin Oncol 26:4600. 2008
  7. pmc A novel role for IQGAP1 protein in cell motility through cell retraction
    Sahar Foroutannejad
    Department of Pharmaceutical Sciences, Southern Illinois University School of Pharmacy, Edwardsville, IL 62026, USA
    Biochem Biophys Res Commun 448:39-44. 2014
  8. pmc IQGAP3 promotes EGFR-ERK signaling and the growth and metastasis of lung cancer cells
    Ying Yang
    Department of Immunology, School of Basic Medical Sciences, Key Laboratory of Medical Immunology of Ministry of Public Health, Peking University Health Science Center, Beijing, P R China
    PLoS ONE 9:e97578. 2014
  9. ncbi Differential expression of IQGAP1/2 in Hepatocellular carcinoma and its relationship with clinical outcomes
    Fa Da Xia
    Department of General Surgery, Xiangya Hospital, Central South University, Changsha, China E mail
    Asian Pac J Cancer Prev 15:4951-6. 2014
  10. doi Involvement of IQGAP family proteins in the regulation of mammalian cell cytokinesis
    Makoto Adachi
    Department of Cell Biology, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto, 606 8501, Japan
    Genes Cells 19:803-20. 2014

Research Grants

  1. KIMBERLEY JANE EVASON; Fiscal Year: 2016
  2. MOLECULAR CHARACTERIZATION OF A THROMBIN RECEPTOR
    Wadie Bahou; Fiscal Year: 2007
  3. Regulation of Actin Assembly and Cell Motility by IQGAPs
    GEORGE BLOOM; Fiscal Year: 2009
  4. Role of IQGAP2 in platelet thrombin signaling
    VALENTINA SCHMIDT; Fiscal Year: 2004

Scientific Experts

  • Krister Wennerberg
  • Valentina A Schmidt
  • Claire Rigothier
  • Catherine S Chew
  • Juan Jose Lozano
  • Fernando Martin-Belmonte
  • David B Sacks
  • GEORGE BLOOM
  • KIMBERLEY JANE EVASON
  • Wadie Bahou
  • Dmitri V Gnatenko
  • Colin D White
  • Jessica M Smith
  • Andrew C Hedman
  • Jing Liu
  • David J Timson
  • Erwan Atcheson
  • Sevvel Pathmanathan
  • Sawako Yamashiro
  • Hongjian Wang
  • Zhuo Deng
  • Khairy Ma Zoheir
  • Huajie Luo
  • Cynthia Brisac
  • Louis LeCour
  • Alper Uzun
  • Raphael Pelossof
  • John D Eicher
  • Sheikh Fayaz Ahmad
  • Ahmed A Abd-Rabou
  • Ashok Kumar
  • Adel R Abd-Allah
  • Gamaleldin I Harisa
  • David K Worthylake
  • Vasudha Srivastava
  • Amr M Ghaleb
  • Khairy M A Zoheir
  • Yuya Sugano
  • Xiaolan Fang
  • Sahar Foroutannejad
  • Fa Da Xia
  • Makoto Adachi
  • Ying Yang
  • Douglas N Robinson
  • Zhigang Li
  • Denise T F McLean
  • Yee Seir Kee
  • Miles J Dixon
  • Yanyun Xie
  • Carmine S Chiariello
  • Raquel Ma Fernández
  • Sachiko Tsukita
  • Hisashi Nojima
  • Elaine Hamilton
  • Jeremy S Logue
  • Ju Dong Yang
  • Yong Yook Lee
  • Kirstin Sandrock
  • Lut Van Laer
  • Koshi Kunimoto
  • Liang Li
  • Shun Hua Jin
  • Yulin Sun
  • Walter Stockinger
  • Issei Mabuchi
  • Hui Wang
  • Patricia McLoughlin
  • Nan Yang
  • Yi Luo
  • Ying Liu
  • Mei Du
  • Ziyu Jiang
  • Juan Chen
  • Xuefeng Hou
  • Liang Feng
  • Huihui Qiu
  • Junfei Gu
  • Gang Wang
  • W David Hill
  • Christina S Leslie
  • Cristen J Willer
  • Jiping Li
  • Fumiko Egawa
  • Xuemei Jiang
  • Lisa R Yanek
  • Leo Pekka Lyytikäinen
  • Jian Hong
  • Joel Hirschhorn
  • Lauren Fairchild
  • Xianting Hu

Detail Information

Publications62

  1. pmc The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases
    S Brill
    Massachusetts General Hospital Cancer Centre, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Mol Cell Biol 16:4869-78. 1996
    ..Like IQGAP1, the novel IQGAP2 protein harbors an N-terminal calponin homology motif which functions as an F-actin binding domain in members of ..
  2. ncbi Cloning and characterization of a novel transcript variant of IQGAP2 in human testis
    Hui Wang
    Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210029, P R of China
    DNA Seq 15:319-25. 2004
    ..The above results suggest the potential role of tsIQGAP2 during spermatogenesis and the mechanism by which tsIQGAP2 regulating spermatogenesis also has been proposed...
  3. ncbi IQGAP2 inactivation through aberrant promoter methylation and promotion of invasion in gastric cancer cells
    Shun Hua Jin
    Department of Molecular Oncology, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, Tokyo, Japan
    Int J Cancer 122:1040-6. 2008
    ..However, the role of another family member, IQGAP2, in carcinogenesis remains unknown. Here, we investigated IQGAP2 functions in gastric cancers...
  4. ncbi IQGAP2 functions as a GTP-dependent effector protein in thrombin-induced platelet cytoskeletal reorganization
    Valentina A Schmidt
    Department of Medicine and the Program in Genetics, State University of New York, Stony Brook, 11794, USA
    Blood 101:3021-8. 2003
    ..The gene encoding the putative rac1/cdc42 effector protein IQGAP2 was identified within the PAR gene cluster at 5q13, flanked telomeric by PAR1 and encompassing PAR3...
  5. pmc Conserved sequence repeats of IQGAP1 mediate binding to Ezrin
    Jing Liu
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1901 Perdido Street, New Orleans, Louisiana 70112, United States
    J Proteome Res 13:1156-66. 2014
    ..ITC also indicates that the ezrin FERM domain binds to the Repeats from IQGAP2 but not the Repeats from IQGAP3...
  6. ncbi Hepatocellular carcinoma in IQGAP2-deficient mice and evaluation of IQGAP2 as a potential novel tumor suppressor gene
    V A Schmidt
    State University of New York Stony Brook, Stony Brook, NY
    J Clin Oncol 26:4600. 2008
    ..In mammals, three homologous IQGAPs (IQGAP1, IQGAP2 and IQGAP3) have been identified, and targeted disruption of the murine Iqgap1 gene has been associated with ..
  7. pmc A novel role for IQGAP1 protein in cell motility through cell retraction
    Sahar Foroutannejad
    Department of Pharmaceutical Sciences, Southern Illinois University School of Pharmacy, Edwardsville, IL 62026, USA
    Biochem Biophys Res Commun 448:39-44. 2014
    ..In addition, we examined co-localization of IQGAP1 with adhesion site markers, myosin IIA, calmodulin and IQGAP2. In areas rich in IQGAP1 there was decreased immunofluorescence staining of vinculin, paxillin and phosphorylated-..
  8. pmc IQGAP3 promotes EGFR-ERK signaling and the growth and metastasis of lung cancer cells
    Ying Yang
    Department of Immunology, School of Basic Medical Sciences, Key Laboratory of Medical Immunology of Ministry of Public Health, Peking University Health Science Center, Beijing, P R China
    PLoS ONE 9:e97578. 2014
    ..IQGAP1 has well documented oncogenic potential and IQGAP2 has putative tumor-suppressive function...
  9. ncbi Differential expression of IQGAP1/2 in Hepatocellular carcinoma and its relationship with clinical outcomes
    Fa Da Xia
    Department of General Surgery, Xiangya Hospital, Central South University, Changsha, China E mail
    Asian Pac J Cancer Prev 15:4951-6. 2014
    To investigate IQGAP1 and IQGAP2 expression in hepatocellular carcinoma (HCC) and itsassociation with HCC clinicopathological characteristics and survival outcomes.
  10. doi Involvement of IQGAP family proteins in the regulation of mammalian cell cytokinesis
    Makoto Adachi
    Department of Cell Biology, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto, 606 8501, Japan
    Genes Cells 19:803-20. 2014
    ..localized to the equatorial cortex at anaphase, whereas IQGAP1 localized to the cell cortex uniformly and IQGAP2 was unexpressed in HeLa cells...
  11. pmc IQGAPs choreograph cellular signaling from the membrane to the nucleus
    Jessica M Smith
    Department of Laboratory Medicine, National Institutes of Health, 10 Center Drive, Building 10, Room 2C306, Bethesda, MD 20892, USA
    Trends Cell Biol 25:171-84. 2015
    ..Investigation of the IQGAP2 and IQGAP3 homologs demonstrates unique functions, some of which differ from those of IQGAP1...
  12. pmc Mechanical stress and network structure drive protein dynamics during cytokinesis
    Vasudha Srivastava
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA
    Curr Biol 25:663-70. 2015
    ..Equatorially enriched proteins including cortexillin I, IQGAP2, and myosin II recovered much more slowly than actin and polar crosslinkers...
  13. pmc The biology of IQGAP proteins: beyond the cytoskeleton
    Andrew C Hedman
    Department of Laboratory Medicine, National Institutes of Health, Bethesda, MD, USA
    EMBO Rep 16:427-46. 2015
    ..Fungal and mammalian IQGAPs are implicated in cytokinesis. IQGAP1, IQGAP2, and IQGAP3 have diverse roles in vertebrate physiology, operating in the kidney, nervous system, cardio-vascular ..
  14. pmc IQ Motif-Containing GTPase-Activating Protein 2 (IQGAP2) Is a Novel Regulator of Colonic Inflammation in Mice
    Amr M Ghaleb
    Department of Medicine, Stony Brook University, Stony Brook, New York, United States of America
    PLoS ONE 10:e0129314. 2015
    IQ motif-containing GTPase-activating protein 2 (IQGAP2) is a multidomain scaffolding protein that plays a role in cytoskeleton regulation by juxtaposing Rho GTPase and Ca2+/calmodulin signals...
  15. doi The Rho-GTPase binding protein IQGAP2 is required for the glomerular filtration barrier
    Yuya Sugano
    Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    Kidney Int 88:1047-56. 2015
    ..One glomerulus-enriched product was the Rho-GTPase binding protein, IQGAP2. Immunohistochemistry found a strong presence of IQGAP2 in normal human and zebrafish podocytes...
  16. doi The European GWAS-identified risk SNP rs457717 within IQGAP2 is not associated with age-related hearing impairment in Han male Chinese population
    Huajie Luo
    Department of Otolaryngology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, 160 Pujian Road Pudong New Area, Shanghai, 200127, People s Republic of China
    Eur Arch Otorhinolaryngol 273:1677-87. 2016
    This study aimed to test the association between the European GWAS-identified risk IQGAP2 SNP rs457717 (A>G) and age-related hearing impairment (ARHI) in a Han male Chinese (HMC) population...
  17. pmc IQGAP3 is essential for cell proliferation and motility during zebrafish embryonic development
    Xiaolan Fang
    Department of Biology, University of Virginia, Charlottesville, Virginia
    Cytoskeleton (Hoboken) 72:422-33. 2015
    ..Vertebrates express 3 family members: IQGAP1, IQGAP2, and IQGAP3...
  18. pmc Gene expression of IQGAPs and Ras families in an experimental mouse model for hepatocellular carcinoma: a mechanistic study of cancer progression
    Khairy M A Zoheir
    Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University P O Box 2457, Riyadh, Saudi Arabia Department of Cell Biology, National Research Centre 12622 Cairo, Egypt
    Int J Clin Exp Pathol 8:8821-31. 2015
    ..The genetic expressions of IQGAP1, IQGAP2, IQGAP3, Hras, Kras, Nras, Mras, Caspase3, and BAX were followed in both hepatocellular carcinoma and normal liver ..
  19. doi Epigenetic regulation of IQGAP2 promotes ovarian cancer progression via activating Wnt/β-catenin signaling
    Zhuo Deng
    Center for Translational Medicine, The First Affiliated Hospital of Xi an Jiaotong University College of Medicine, Xi an 710061, P R China
    Int J Oncol 48:153-60. 2016
    ..from The Cancer Genome Atlas, we unveiled the abnormalities in gene methylation of ovarian cancers, and found that IQGAP2 one of the most frequently altered genes, was significantly hypermethylated in ovarian cancer...
  20. pmc Integrated genomic profiling identifies microRNA-92a regulation of IQGAP2 in locally advanced rectal cancer
    Raphael Pelossof
    Computational Biology Program, Department of Surgery, Memorial Sloan Kettering Institute, NY
    Genes Chromosomes Cancer 55:311-21. 2016
    ..Cell line studies using miR-92a mimics and inhibitors demonstrate that miR-92a expression regulates IQGAP2 expression...
  21. pmc Targeted Sequencing and Meta-Analysis of Preterm Birth
    Alper Uzun
    Department of Pediatrics, Women and Infants Hospital of Rhode Island, Providence, Rhode Island, United States of America
    PLoS ONE 11:e0155021. 2016
    ..The most frequently identified and connected genes in the exome library were IGF1, ATM and IQGAP2. Likewise, SOS1, RAF1 and AKT3 were most frequent in the haplotype library...
  22. pmc Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals
    John D Eicher
    Population Sciences Branch, National Heart Lung and Blood Institute, The Framingham Heart Study, Framingham, MA 01702, USA
    Am J Hum Genet 99:40-55. 2016
    ..in the literature across the allele frequency spectrum, including rare large effect (FCER1A), low-frequency (IQGAP2, MAP1A, LY75), and common (ZMIZ2, SMG6, PEAR1, ARFGAP3/PACSIN2) variants...
  23. doi Nuclear translocation of IQGAP1 protein upon exposure to puromycin aminonucleoside in cultured human podocytes: ERK pathway involvement
    Claire Rigothier
    Bristol Renal, University of Bristol, Bristol, United Kingdom INSERM U1026, Universite de Bordeaux, Bordeaux, France Service de Néphrologie Transplantation Dialyse, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France Electronic address
    Cell Signal 28:1470-8. 2016
    ..In contrast to IQGAP1, IQGAP2 expression remained cytoplasmic...
  24. doi IQGAP2 is a novel interferon-alpha antiviral effector gene acting non-conventionally through the NF-κB pathway
    Cynthia Brisac
    Liver Center and Gastrointestinal Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Hepatol 65:972-979. 2016
    ..Using unbiased genome-wide siRNA screens, we recently identified IQ-motif containing GTPase activating protein 2 (IQGAP2), a tumor suppressor predominantly expressed in the liver, as a novel gene putatively required for IFN antiviral ..
  25. ncbi IQGAP1 gene silencing induces apoptosis and decreases the invasive capacity of human hepatocellular carcinoma cells
    Khairy Ma Zoheir
    Pharmacology and Toxicology Department, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
    Tumour Biol 37:13927-13939. 2016
    ..IQGAP1 is expressed in all cells, while IQGAP2 and IQGAP3 are mainly expressed in hepatic cells...
  26. pmc The Structural Basis for Cdc42-Induced Dimerization of IQGAPs
    Louis LeCour
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Structure 24:1499-508. 2016
    ..present the crystal structure of Cdc42·GTP bound to the GTPase-activating protein (GAP)-related domain (GRD) of IQGAP2. Four molecules of Cdc42 are bound to two GRD molecules, which bind each other in a parallel dimer...
  27. doi Anti-inflammatory effect of miltirone on inflammatory bowel disease via TLR4/NF-κB/IQGAP2 signaling pathway
    Hongjian Wang
    The Fifth Department of Digestion, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, PR China
    Biomed Pharmacother 85:531-540. 2017
    ..Miltirone could up-regulate the descreased IQGAP2 expression induced by LPS...
  28. pmc IQ-motif selectivity in human IQGAP2 and IQGAP3: binding of calmodulin and myosin essential light chain
    Erwan Atcheson
    School of Biological Sciences, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, U K
    Biosci Rep 31:371-9. 2011
    ..Using synthetic peptides and native gel electrophoresis, the binding properties of the IQ-motifs from human IQGAP2 and IQGAP3 have been mapped...
  29. doi The nuclear import of the small GTPase Rac1 is mediated by the direct interaction with karyopherin alpha2
    Kirstin Sandrock
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Albert Ludwigs Universitat, Freiburg, Germany
    Traffic 11:198-209. 2010
    ..Liquid chromatography tandem mass spectrometry (LC-MS/MS) analysis revealed that nuclear Rac1 coimmunoprecipitates with numerous proteins. In the nucleus, Rac1 may participate in a variety of so far uncharacterized processes...
  30. pmc Transcript profiling identifies iqgap2(-/-) mouse as a model for advanced human hepatocellular carcinoma
    Dmitri V Gnatenko
    Department of Medicine, Stony Brook University, Stony Brook, New York, United States of America
    PLoS ONE 8:e71826. 2013
    ..A new hepatocellular carcinoma (HCC) mouse model lacking a novel putative tumor suppressor IQGAP2 has been generated by our laboratory...
  31. pmc Differential requirements for actin polymerization, calmodulin, and Ca2+ define distinct stages of lysosome/phagosome targeting
    Walter Stockinger
    Department of Molecular and Cellular Biology, The Biological Laboratories, Harvard University, Cambridge, MA 02138, USA
    Mol Biol Cell 17:1697-710. 2006
    ..Major proteins in the active fractions included actin, calmodulin and IQGAP2. IQGAPs are known to bind calmodulin and cross-link F-actin, suggesting a key coordinating role during lysosome/..
  32. ncbi Transcriptional responses to epigallocatechin-3 gallate in HT 29 colon carcinoma spheroids
    Patricia McLoughlin
    Roche Centre for Medical Genomics, F Hoffmann La Roche, Ltd, Postfach, 4070 Basel, Switzerland
    Genes Cells 9:661-9. 2004
    ..In agreement with the DNA chip data, IQGAP2 protein was not increased in spheroids but protein formation was totally blocked in EGCG-treated cells...
  33. pmc IQGAP proteins are integral components of cytoskeletal regulation
    Michael W Briggs
    Brigham and Women s Hospital, Thorn 530, 75 Francis Street, Boston, MA 02115, USA
    EMBO Rep 4:571-4. 2003
    ..the structure and function of IQGAP1 as a member of the family of IQGAP proteins and summarize the current knowledge about IQGAP1 and IQGAP2. Collectively, these data reveal that IQGAP1 is a fundamental regulator of cytoskeletal function.
  34. pmc Polarized distribution of IQGAP proteins in gastric parietal cells and their roles in regulated epithelial cell secretion
    Rihong Zhou
    Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Mol Biol Cell 14:1097-108. 2003
    ..In addition, we revealed that two Cdc42 regulators, IQGAP1 and IQGAP2, are present in gastric parietal cells...
  35. pmc Four new loci associations discovered by pathway-based and network analyses of the genome-wide variability profile of Hirschsprung's disease
    Raquel Ma Fernández
    Department of Genetics, Reproduction and Fetal Medicine, Institute of Biomedicine of Seville IBIS, University Hospital Virgen del Rocío CSIC University of Seville, Seville, Spain
    Orphanet J Rare Dis 7:103. 2012
    ..Among the preselected candidates, a total of 4 loci, RASGEF1A, IQGAP2, DLC1 and CHRNA7, related to signal transduction and migration processes, were found to be significantly ..
  36. doi IQ-motif peptides as novel anti-microbial agents
    Denise T F McLean
    Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Health Sciences Building, 97 Lisburn Road, Belfast BT9 7AE, UK
    Biochimie 95:875-80. 2013
    ..tested eight peptides encoding the sequences of IQ-motifs derived from the human cytoskeletal scaffolding proteins IQGAP2 and IQGAP3...
  37. pmc Watch the GAP: Emerging Roles for IQ Motif-Containing GTPase-Activating Proteins IQGAPs in Hepatocellular Carcinoma
    Valentina A Schmidt
    Department of Medicine, Stony Brook University, Stony Brook, NY 11794 8151, USA
    Int J Hepatol 2012:958673. 2012
    IQ motif-containing GTPase-activating proteins IQGAP1 and IQGAP2 are highly homologous multidomain scaffolding proteins...
  38. pmc IQGAP proteins reveal an atypical phosphoinositide (aPI) binding domain with a pseudo C2 domain fold
    Miles J Dixon
    Division of Cell Signalling and Immunology, College of Life Sciences, University of Dundee, Dow St, Dundee DD1 5EH, Scotland, United Kingdom
    J Biol Chem 287:22483-96. 2012
    ..The crystal structure of the C-terminal IQGAP2 PI binding module reveals unexpected topological similarity to an integral fold of C2 domains, including a ..
  39. doi IQGAP2, A candidate tumour suppressor of prostate tumorigenesis
    Yanyun Xie
    Division of Nephrology, Department of Medicine, Canada
    Biochim Biophys Acta 1822:875-84. 2012
    Loss of IQGAP2 contributes to the tumorigenesis of hepatocellular carcinoma and gastric cancer. However, whether IQGAP2 also suppresses prostate tumorigenesis remains unclear...
  40. pmc A mechanosensory system governs myosin II accumulation in dividing cells
    Yee Seir Kee
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Biol Cell 23:1510-23. 2012
    ..Here we show that the regulatory and contractility network composed of myosin II, cortexillin I, IQGAP2, kinesin-6 (kif12), and inner centromeric protein (INCENP) is a mechanical stress-responsive system...
  41. doi Involvement of IQGAP3, a regulator of Ras/ERK-related cascade, in hepatocyte proliferation in mouse liver regeneration and development
    Koshi Kunimoto
    Laboratory of Biological Science, Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University, Osaka 565 0871, Japan
    J Cell Physiol 220:621-31. 2009
    ..In immunofluorescence, IQGAP3 was highly enriched at cell-cell contacts of hepatocytes. IQGAP1 and IQGAP2 were exclusively expressed in Kupffer and sinusoidal endothelial cells, respectively, in normal, regenerating, and ..
  42. ncbi RhoG signals in parallel with Rac1 and Cdc42
    Krister Wennerberg
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599 7295, USA
    J Biol Chem 277:47810-7. 2002
    ..Thus, RhoG may be activated concurrently with Rac1 and Cdc42. Second, some effectors of Rac/Cdc42 (IQGAP2, MLK-3, PLD1), but not others (e.g...
  43. ncbi Localization of two IQGAPs in cultured cells and early embryos of Xenopus laevis
    Sawako Yamashiro
    Division of Biology, Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, Komaba, Meguro ku, Tokyo 153 8902, Japan
    Cell Motil Cytoskeleton 55:36-50. 2003
    ..cDNAs encoding homologues of mammalian IQGAP, XIQGAP1, and XIQGAP2, which show high homology with human IQGAP1 and IQGAP2, respectively...
  44. ncbi Evidence that HAX-1 is an interleukin-1 alpha N-terminal binding protein
    H Yin
    Orthopaedic Research Laboratories, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Cytokine 15:122-37. 2001
    ..HAX-1 may serve to retain the IL-1 NTP in the cytoplasm, and complex formation between the IL-1 NTP and HAX-1 may play a role in motility and/or adhesion of cells...
  45. pmc Gastric hyperplasia in mice lacking the putative Cdc42 effector IQGAP1
    S Li
    Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Mol Cell Biol 20:697-701. 2000
    ..While we cannot exclude that functional redundancy with IQGAP2 contributes to the lack of developmental phenotypes, the restricted expression pattern of IQGAP2 is not obviously ..
  46. ncbi Characterization of the interactions between the small GTPase Cdc42 and its GTPase-activating proteins and putative effectors. Comparison of kinetic properties of Cdc42 binding to the Cdc42-interactive domains
    B Zhang
    Department of Biochemistry, University of Tennessee, Memphis, Tennessee 38163, USA
    J Biol Chem 272:21999-2007. 1997
    ..the Cdc42/Rac interactive binding (CRIB) motif-containing molecules, and the RasGAP domain containing IQGAP1 and IQGAP2. In the present study, we have determined the kinetic parameters underlying the functional interactions between ..
  47. ncbi IQGAPs are differentially expressed and regulated in polarized gastric epithelial cells
    Catherine S Chew
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912 3175, USA
    Am J Physiol Gastrointest Liver Physiol 288:G376-87. 2005
    ..Recently, Cdc42 was implicated in regulation of gastric parietal cell HCl secretion, and IQGAP2 was immunolocalized with Cdc42 to F-actin-rich intracellular canalicular membranes of isolated gastric parietal ..
  48. pmc Dual activation of pathways regulated by steroid receptors and peptide growth factors in primary prostate cancer revealed by Factor Analysis of microarray data
    Juan Jose Lozano
    Bioinformatics Unit, Centro de Biologia Molecular Severo Ochoa CSIC UAM, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    BMC Genomics 6:109. 2005
    ..We tested the approach with a published dataset of microarray experiments in yeast. Upon validation with the yeast dataset, we applied the technique to a prostate cancer dataset...
  49. ncbi Identification of a putative effector for Cdc42Hs with high sequence similarity to the RasGAP-related protein IQGAP1 and a Cdc42Hs binding partner with similarity to IQGAP2
    S J McCallum
    Department of Biochemistry, Veterinary Medical Center, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 271:21732-7. 1996
    ..identity with the human IQGAP1 protein, while two peptides derived from p175 were 89 and 100% identical to human IQGAP2. These findings identify IQGAP1 and IQGAP2 as a new class of target/effectors that utilize both regions of the ..
  50. pmc PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc42
    Fernando Martin-Belmonte
    Department of Anatomy, University of California, San Francisco, CA 94143, USA
    Cell 128:383-97. 2007
    ..Loss of function of PTEN, Anx2, Cdc42, or aPKC prevents normal development of the apical surface and lumen. We conclude that the mechanism of PTEN, PtdIns(4,5)P2, Anx2, Cdc42, and aPKC controls apical plasma membrane and lumen formation...
  51. ncbi IQGAP2 is required for the cadherin-mediated cell-to-cell adhesion in Xenopus laevis embryos
    Sawako Yamashiro
    Division of Biology, Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, Komaba, Meguro ku, Tokyo 153 8902, Japan
    Dev Biol 308:485-93. 2007
    ..two Xenopus homologues of mammalian IQGAP, XIQGAP1 and XIQGAP2, which show high homology with human IQGAP1 and IQGAP2, respectively...
  52. pmc Development of hepatocellular carcinoma in Iqgap2-deficient mice is IQGAP1 dependent
    Valentina A Schmidt
    Division of Hematology, HSC T15, Rm 040, State University of New York at Stony Brook, Stony Brook, NY 11794 8151, USA
    Mol Cell Biol 28:1489-502. 2008
    ..Targeted disruption of the murine Iqgap2 gene resulted in the age-dependent development of apoptosis and hepatocellular carcinoma (HCC), characterized by ..
  53. doi Quantitative proteomic signature of liver cancer cells: tissue transglutaminase 2 could be a novel protein candidate of human hepatocellular carcinoma
    Yulin Sun
    State Key Laboratory of Molecular Oncology, Department of Abdominal Surgery, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021 P R China
    J Proteome Res 7:3847-59. 2008
    ..such as AFP, intercellular adhesion molecule-1 (ICAM-1), IQ motif containing GTPase activating protein 2 (IQGAP2), claudin-1 (CLDN1) and tissue transglutaminase 2 (TGM2), were validated both in multiple cell lines and in 61 ..
  54. pmc IQGAPs in cancer: a family of scaffold proteins underlying tumorigenesis
    Colin D White
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    FEBS Lett 583:1817-24. 2009
    ..b>IQGAP2 and IQGAP3 harbor all the domains identified in IQGAP1, but their biological roles are poorly defined...
  55. pmc Gemcitabine and arabinosylcytosin pharmacogenomics: genome-wide association and drug response biomarkers
    Liang Li
    Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, USA
    PLoS ONE 4:e7765. 2009
    ..One SNP in IQGAP2 (rs3797418) was significantly associated with variation in both the expression of multiple genes and gemcitabine ..
  56. pmc A genome-wide association study for age-related hearing impairment in the Saami
    Lut Van Laer
    Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
    Eur J Hum Genet 18:685-93. 2010
    ..was associated with PC3 and was localised in an intron of the IQ motif-containing GTPase-activating-like protein (IQGAP2). Intriguingly, the SNP rs161927 (P-value 0...
  57. pmc IQGAP1 and IQGAP2 are reciprocally altered in hepatocellular carcinoma
    Colin D White
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    BMC Gastroenterol 10:125. 2010
    IQGAP1 and IQGAP2 are homologous members of the IQGAP family of scaffold proteins. Accumulating evidence implicates IQGAPs in tumorigenesis...
  58. pmc Sulfatase 1 and sulfatase 2 in hepatocellular carcinoma: associated signaling pathways, tumor phenotypes, and survival
    Ju Dong Yang
    Miles and Shirley Fiterman Center for Digestive Diseases, College of Medicine, Mayo Clinic and Mayo Clinic Cancer Center, Rochester, MN, USA
    Genes Chromosomes Cancer 50:122-35. 2011
    ..strong positive correlations with periostin, IQGAP1, TGFB1, and vimentin and inverse correlations with HNF4A and IQGAP2. Genes correlated with both SULFs were highly associated with the cell adhesion, cytoskeletal remodeling, blood ..
  59. pmc Ablation of Iqgap2 protects from diet-induced hepatic steatosis due to impaired fatty acid uptake
    Carmine S Chiariello
    Program in Genetics, Stony Brook University, Stony Brook, NY 11794, USA
    Regul Pept 173:36-46. 2012
    ..Our previous work using mice deficient of the Iqgap2 gene established a highly novel link between IQGAP2, a putative GTPase-activating protein, and ..
  60. doi Subcellular tissue proteomics of hepatocellular carcinoma for molecular signature discovery
    Yong Yook Lee
    Department of Research, Carolinas HealthCare System, Charlotte, NC, USA
    J Proteome Res 10:5070-83. 2011
    ..Furthermore, we validated the potential molecular targets of HCC, MATR3, LETM1, ILF2, and IQGAP2 by Western blotting, immunohistochemisty, and immunofluorescent microscopy...
  61. pmc Anchored protein kinase A recruitment of active Rac GTPase
    Jeremy S Logue
    Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Biol Chem 286:22113-21. 2011
    ..of a ternary complex of AKAP220, the PKA holoenzyme, and the IQ domain GTPase-activating protein 2 isoform (IQGAP2) that is enriched at cortical regions of the cell...
  62. doi The interaction of IQGAPs with calmodulin-like proteins
    Sevvel Pathmanathan
    School of Biological Sciences, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
    Biochem Soc Trans 39:694-9. 2011
    ..The three human IQGAP isoforms (IQGAP1, IQGAP2 and IQGAP3) all have four IQ motifs...

Research Grants4

  1. KIMBERLEY JANE EVASON; Fiscal Year: 2016
    ..promotes tumor formation in fish via activation of specific genes, including myc, epcam, lef1, foxo1a, and iqgap2, and regulation of specific microRNAs. Dr...
  2. MOLECULAR CHARACTERIZATION OF A THROMBIN RECEPTOR
    Wadie Bahou; Fiscal Year: 2007
    ..functional genomics," we have identified and initially characterized a putative racl/cdc42 effector protein (IQGAP2) uniquely situated within the protease-activated gene cluster on chromosome 5q13...
  3. Regulation of Actin Assembly and Cell Motility by IQGAPs
    GEORGE BLOOM; Fiscal Year: 2009
    ..These include IQGAP2, which is known to exist at the protein level, and IQGAP3, which has been inferred from genomic DNA and expressed ..
  4. Role of IQGAP2 in platelet thrombin signaling
    VALENTINA SCHMIDT; Fiscal Year: 2004
    ..Genomic analysis of the PAR cluster on chromosome 5813 identified the gene encoding IQGAP2, a putative Rho GTPase-activating protein (GAP), in close proximity to the PAR1 gene...