interleukin 5

Summary

Gene Symbol: interleukin 5
Description: interleukin 5
Alias: EDF, IL-5, TRF, interleukin-5, B-cell differentiation factor I, T-cell replacing factor, colony-stimulating factor, eosinophil, eosinophil differentiation factor
Species: human

Top Publications

  1. ncbi Effects of alloxan-induced diabetes on hemorheology in rabbits
    C D Brown
    State University of New York Health Science Center, Brooklyn
    Horm Metab Res 24:254-7. 1992
  2. ncbi Activation of 12-O-tetradecanoylphorbol-13-acetate response element- and dyad symmetry element-dependent transcription by interleukin-5 is mediated by Jun N-terminal kinase/stress-activated protein kinase kinases
    R P de Groot
    Department of Pulmonary Diseases, G03 550, University Hospital Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    J Biol Chem 272:2319-25. 1997
  3. ncbi A putative silencer element in the IL-5 gene recognized by Bcl6
    Masafumi Arima
    Department of Developmental Genetics H2, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Immunol 169:829-36. 2002
  4. ncbi Effect of mitomycin C on the secretion of granulocyte macrophages colonies stimulating factor and interleukin-5 in eosinophilic nasal polyps stromal culture
    Paulo Fernando Tormin Borges Crosara
    Department of Ophthalmology, Otorhinolaryngology and Speech and Hearing Therapy, Federal University of Minas Gerais
    Braz J Otorhinolaryngol 71:459-63. 2005
  5. doi Primary eosinophilic disorders of the gastrointestinal tract
    B M Yan
    Division of Gastroenterology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    Gut 58:721-32. 2009
  6. ncbi Expression of interleukin-5- and granulocyte macrophage-colony-stimulating factor-responsive genes in blood and airway eosinophils
    Mary E Bates
    Department of Biomolecular Chemistry, University of Wisconsin, 1300 University Ave, Madison, WI 53706, USA
    Am J Respir Cell Mol Biol 30:736-43. 2004
  7. ncbi Interleukin-13 and interleukin-5 in induced sputum of eosinophilic bronchitis: comparison with asthma
    Sung Woo Park
    Asthma and AAllergy Research Group, Soonchunhyang University, Bucheon Hospital, 1174, Jung Dong, Wonmi Ku, Bucheon, Gyeonggi Do, 420 021, Korea
    Chest 128:1921-7. 2005
  8. doi Analysis of polymorphisms in olive pollen allergy: IL13, IL4RA, IL5 and ADRB2 genes
    Elena Llanes
    Servicio de Inmunologia, Fundacion Jimenez Diaz Capio, CIBERES ISCIII, Madrid, Spain
    Int Arch Allergy Immunol 148:228-38. 2009
  9. doi Proviral integration site for Moloney murine leukemia virus 1, but not phosphatidylinositol-3 kinase, is essential in the antiapoptotic signaling cascade initiated by IL-5 in eosinophils
    Nicola Andina
    Institute of Pharmacology, University of Bern, Bern, Switzerland
    J Allergy Clin Immunol 123:603-11. 2009
  10. doi Association analysis of polymorphisms in IL-3, IL-4, IL-5, IL-9, and IL-13 with Graves' disease
    W Zhu
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Key Laboratory for Endocrine Tumors, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P R China
    J Endocrinol Invest 33:751-5. 2010

Research Grants

  1. PATRICIA CHANDHOK FULKERSON; Fiscal Year: 2015
  2. Anti- IL5 therapy for Churg-Strauss Syndrome: a double blind randomized, placebo-
    Michael E Wechsler; Fiscal Year: 2010
  3. MECHANISMS OF PULMONARY FIBROSIS
    Sem H Phan; Fiscal Year: 2010
  4. Mechanisms of Virus-Induced Hyperreactivity in Atopics
    David B Jacoby; Fiscal Year: 2010
  5. Mouse models for the functional analysis of asthma-associated human polymorphisms
    Donata Vercelli; Fiscal Year: 2009
  6. Michael E Wechsler; Fiscal Year: 2016
  7. Daniela Cihakova; Fiscal Year: 2015
  8. Jonathan Savitz; Fiscal Year: 2016
  9. Involvement of Natural Killer T cells in Hepatic Fibrogenesis
    Ian N Hines; Fiscal Year: 2011
  10. MOUSE MODEL OF EOSINOPHIL MEDIATED SKIN PATHOLOGY
    James Lee; Fiscal Year: 1999

Detail Information

Publications364 found, 100 shown here

  1. ncbi Effects of alloxan-induced diabetes on hemorheology in rabbits
    C D Brown
    State University of New York Health Science Center, Brooklyn
    Horm Metab Res 24:254-7. 1992
    ..apparent whole blood viscosity (WBV), relative blood viscosity (RV) and erythrocyte deformability (filterability) (EDF) were determined in 13 New Zealand White (NZW) rabbits with alloxan induced-diabetes (AID) and 8 normal NZW rabbits,..
  2. ncbi Activation of 12-O-tetradecanoylphorbol-13-acetate response element- and dyad symmetry element-dependent transcription by interleukin-5 is mediated by Jun N-terminal kinase/stress-activated protein kinase kinases
    R P de Groot
    Department of Pulmonary Diseases, G03 550, University Hospital Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    J Biol Chem 272:2319-25. 1997
    ..Taken together, we show for the first time that IL-5 activates kinases of the JNK/SAPK family, and that this activation is linked to IL-5-induced TRE- and DSE-dependent transcription...
  3. ncbi A putative silencer element in the IL-5 gene recognized by Bcl6
    Masafumi Arima
    Department of Developmental Genetics H2, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Immunol 169:829-36. 2002
    ..Furthermore, the IL5BS was required for Bcl6 to repress expression of the IL-5 cDNA. Thus, the IL5BS may act as a silencer element for Bcl6 to repress expression of the IL-5 gene...
  4. ncbi Effect of mitomycin C on the secretion of granulocyte macrophages colonies stimulating factor and interleukin-5 in eosinophilic nasal polyps stromal culture
    Paulo Fernando Tormin Borges Crosara
    Department of Ophthalmology, Otorhinolaryngology and Speech and Hearing Therapy, Federal University of Minas Gerais
    Braz J Otorhinolaryngol 71:459-63. 2005
    The research involving tissue factors, such as granulocyte macrophage colonies stimulating factor (GM-CSF) and interleukin 5 (IL-5), leads to the mechanisms involved in the maintenance of eosinophilia, which is essential for the ..
  5. doi Primary eosinophilic disorders of the gastrointestinal tract
    B M Yan
    Division of Gastroenterology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    Gut 58:721-32. 2009
    ..A more comprehensive basis for eosinophilic infiltration and activation has identified interleukin 5 (IL5) as a key cytokine for the differentiation and proliferation of eosinophils, while eotaxins promote the ..
  6. ncbi Expression of interleukin-5- and granulocyte macrophage-colony-stimulating factor-responsive genes in blood and airway eosinophils
    Mary E Bates
    Department of Biomolecular Chemistry, University of Wisconsin, 1300 University Ave, Madison, WI 53706, USA
    Am J Respir Cell Mol Biol 30:736-43. 2004
    ..e., lymphotoxin beta and CD24). These studies have identified several transcriptional targets of IL-5 and GM-CSF in human eosinophils and suggest that a number of protein products are critical to the responsiveness of airway eosinophils...
  7. ncbi Interleukin-13 and interleukin-5 in induced sputum of eosinophilic bronchitis: comparison with asthma
    Sung Woo Park
    Asthma and AAllergy Research Group, Soonchunhyang University, Bucheon Hospital, 1174, Jung Dong, Wonmi Ku, Bucheon, Gyeonggi Do, 420 021, Korea
    Chest 128:1921-7. 2005
    ..This study evaluated the role of IL-13 in asthma by comparing the sputum IL-5 and IL-13 levels in both groups...
  8. doi Analysis of polymorphisms in olive pollen allergy: IL13, IL4RA, IL5 and ADRB2 genes
    Elena Llanes
    Servicio de Inmunologia, Fundacion Jimenez Diaz Capio, CIBERES ISCIII, Madrid, Spain
    Int Arch Allergy Immunol 148:228-38. 2009
    ....
  9. doi Proviral integration site for Moloney murine leukemia virus 1, but not phosphatidylinositol-3 kinase, is essential in the antiapoptotic signaling cascade initiated by IL-5 in eosinophils
    Nicola Andina
    Institute of Pharmacology, University of Bern, Bern, Switzerland
    J Allergy Clin Immunol 123:603-11. 2009
    ..IL-5-mediated transmembrane signal transduction involves both Lyn-mitogen-activated protein kinases and Janus kinase 2-signal transducer and activator of transcription pathways...
  10. doi Association analysis of polymorphisms in IL-3, IL-4, IL-5, IL-9, and IL-13 with Graves' disease
    W Zhu
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Key Laboratory for Endocrine Tumors, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P R China
    J Endocrinol Invest 33:751-5. 2010
    ..The aim of the present study is to elucidate whether the single nucleotide polymorphisms (SNP) and the interaction of variants in the 5 genes are associated with the development of GD and Graves' ophthalmopathy (GO)...
  11. ncbi Inhibition of interleukin-5 for the treatment of eosinophilic diseases
    Jonathan Corren
    Department of Medicine, University of California, Los Angeles, 10780 Santa Monica Blvd, Suite 280, Los Angeles, California 90025, USA
    Discov Med 13:305-12. 2012
    ..Strategies aimed at the inhibition of IL-5 may hold great promise in the treatment of eosinophilic diseases...
  12. pmc Molecular cloning and expression of the human interleukin 5 receptor
    Y Murata
    Department of Biology, Kumamoto University Medical School, Japan
    J Exp Med 175:341-51. 1992
    Human interleukin 5 (IL-5) plays an important role in proliferation and differentiation of human eosinophils...
  13. ncbi A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific alpha chain and a beta chain shared with the receptor for GM-CSF
    J Tavernier
    Roche Research Gent, Belgium
    Cell 66:1175-84. 1991
    cDNA clones encoding two receptor proteins involved in the binding of human interleukin 5 (hIL5) have been isolated. A first class codes for an IL5-specific chain (hIL5R alpha)...
  14. pmc Cloning of cDNA for human T-cell replacing factor (interleukin-5) and comparison with the murine homologue
    C Azuma
    Nucleic Acids Res 14:9149-58. 1986
    ..Human interleukin-5 synthesized by the direction of the cloned cDNA induced immunoglobulin synthesis in human B cells stimulated by Staphylococcus aureus mitogen...
  15. pmc Molecular cloning, nucleotide sequence, and expression of the gene encoding human eosinophil differentiation factor (interleukin 5)
    H D Campbell
    Medical Molecular Biology Unit, John Curtin School of Medical Research, Australian National University, Canberra, A C T
    Proc Natl Acad Sci U S A 84:6629-33. 1987
    The human eosinophil differentiation factor (EDF) gene was cloned from a genomic library in lambda phage EMBL3A by using a murine EDF cDNA clone as a probe. The DNA sequence of a 3...
  16. ncbi A novel dimer configuration revealed by the crystal structure at 2.4 A resolution of human interleukin-5
    M V Milburn
    Laboratory of Molecular Medicine, Children s Hospital Ender 673, Boston, Massachusetts 02115 5737
    Nature 363:172-6. 1993
    ..This structure determination extends the family of the cytokine bundle of four helices and emphasizes its fundamental significance and versatility in recognizing its receptor...
  17. ncbi Two pathways can activate the interleukin-5 gene and induce binding to the conserved lymphokine element 0
    S Karlen
    TVW Telethon Institute for Child Health Research, Perth, Australia
    Blood 88:211-21. 1996
    ....
  18. ncbi Diesel exhaust particles enhance airway responsiveness following allergen exposure in mice
    H Takano
    Research Team for Health Effects of Air Pollutants, National Institute for Environmental Studies, Ibaraki, Japan
    Immunopharmacol Immunotoxicol 20:329-36. 1998
    ....
  19. ncbi CD30 antigen: not a physiological marker for TH2 cells but an important costimulator molecule in the regulation of the balance between TH1/TH2 response
    Patrizia Pellegrini
    Istituto CNR Trapianti d Organo e l Immunocitologia, Ple Collemaggio, 67100 L Aquila, Italy
    Transpl Immunol 12:49-61. 2003
    ....
  20. ncbi Evaluation of accuracy and uncertainty of ELISA assays for the determination of interleukin-4, interleukin-5, interferon-gamma and tumor necrosis factor-alpha
    Lone Borg
    Reference Laboratory, National Institute of Occupational Health, Copenhagen, Denmark
    Clin Chem Lab Med 40:509-19. 2002
    ..The model for evaluating uncertainty presented in this paper is applicable to other types of assays and to most analytical methods...
  21. ncbi Uterine eosinophils and reproductive performance in interleukin 5-deficient mice
    S A Robertson
    Department of Obstetrics and Gynaecology and Reproductive Medicine Unit, University of Adelaide, Adelaide, SA 5005, Australia
    J Reprod Fertil 120:423-32. 2000
    b>Interleukin 5 is expressed in type 2 T lymphocytes and has a key role in driving the differentiation, recruitment and activation of eosinophils...
  22. doi Mepolizumab for prednisone-dependent asthma with sputum eosinophilia
    Parameswaran Nair
    Firestone Institute for Respiratory Health, St Joseph s Healthcare and Department of Medicine, McMaster University, Hamilton, ON, Canada
    N Engl J Med 360:985-93. 2009
    ..Secondary objectives were to examine its effect on the number of eosinophils in sputum and blood, symptoms, and airflow limitation...
  23. ncbi Abnormal clones of T cells producing interleukin-5 in idiopathic eosinophilia
    H U Simon
    Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos
    N Engl J Med 341:1112-20. 1999
    ..We examined T-cell surface markers, rearranged T-cell-receptor genes, and in vitro production of cytokines by T cells from patients with idiopathic eosinophilia...
  24. ncbi Effects of chronic anti-interleukin-5 monoclonal antibody treatment in a murine model of pulmonary inflammation
    C G Garlisi
    Allergy and Immunology, Schering Plough Research Institute, Kenilworth, New Jersey 07033 0539, USA
    Am J Respir Cell Mol Biol 20:248-55. 1999
    ..Thus, the biologic duration of TRFK-5 was several months, and its activity was due to the presence of antibody above a therapeutic threshold rather than to any profound effect on the immune system...
  25. pmc Eosinophilia in transgenic mice expressing interleukin 5
    L A Dent
    National Institute for Medical Research, Mill Hill, London, United Kingdom
    J Exp Med 172:1425-31. 1990
    Experiments in vitro suggest that although interleukin 5 (IL-5) stimulates the late stages of eosinophil differentiation, other cytokines are required for the generation of eosinophil progenitor cells...
  26. ncbi [The role of protein kinase C and activator protein-1 signal cascade in the regulation of expression of interleukin-5 in T lymphocyte of allergic rhinitis]
    Yamin Zhang
    Department of Otorhinolaryngology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China
    Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 21:71-4. 2007
    ..To explore the role of protein kinase C (PKC) and activator protein-1 (AP-1) in the signal transduction cascade in the expression of interleukin-5 (IL-5) by peripheral blood T lymphocytes from allergic rhinitis...
  27. ncbi Valproate-induced eosinophilia in children with epilepsy: role of interleukin-5
    Alexandros C Makis
    Department of Child Health, University Hospital of Ioannina, Ionnina, Greece
    J Child Neurol 20:150-2. 2005
    ....
  28. ncbi Airway hyperresponsiveness: first eosinophils and then neuropeptides
    A D Kraneveld
    Department of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, The Netherlands
    Int J Immunopharmacol 19:517-27. 1997
    ..Following this step, eosinophil-derived inflammatory mediators will induce the release of sensory neuropeptides (possibly NK2-receptor activating tachykinins) which in turn will lead to airway hyperresponsiveness...
  29. ncbi Interactions between eotaxin and interleukin-5 in the chemotaxis of primed and non-primed human eosinophils
    Gislaine G Costa
    Department of Pharmacology, Faculty of Medical Sciences, UNICAMP, Campinas SP, Brazil
    Eur J Pharmacol 566:200-5. 2007
    ..Our finding that eotaxin inhibits the enhanced eosinophil chemotaxis toward interleukin-5 in primed cells suggests that this chemokine may downregulate eosinophil accumulation in the nasal mucosa of allergic patients...
  30. doi Gene expression in nasal lavage from hairdressers exposed to persulphate
    Lena S Jönsson
    Division of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University Hospital, Lund, Sweden
    Int Arch Occup Environ Health 82:1261-6. 2009
    ..In this study, we analysed gene expression of cytokines in the nose in order to further investigate the mechanism for work-related bleaching powder-associated nasal symptoms...
  31. pmc Anti-IL5 decreases the number of eosinophils but not the severity of dermatitis in Sharpin-deficient mice
    Matthew L Renninger
    Department of Comparative Pathobiology, Purdue University, West Lafayette, IN, USA
    Exp Dermatol 19:252-8. 2010
    ..These data indicate that eosinophils are not essential for the development of dermatitis in Sharpin(cpdm) mice and suggest that eosinophils have both pro-inflammatory and anti-inflammatory roles in the skin of these mice...
  32. pmc Inhibitory effect of heparin-derived oligosaccharides on secretion of interleukin-4 and interleukin-5 from human peripheral blood T lymphocytes
    Sheng Li Ji
    Key Laboratory of Marine Drugs, Marine Drug and Food Institute, Ocean University of China, Qingdao 266003, Shandong Province, China
    World J Gastroenterol 10:3490-4. 2004
    ..To investigate the inhibitory effect of heparin-derived oligosaccharides (Oligs) on secretion of interleukin-4 (IL-4) and interleukin-5 (IL-5) from human peripheral blood T lymphocytes (PBTLs)...
  33. ncbi Gene microarray analysis reveals interleukin-5-dependent transcriptional targets in mouse bone marrow
    Jonas Bystrom
    NIAID, NIH, Bldg 10, Rm 11N104, 9000 Rockville Pike, Bethesda, MD, 20892, USA
    Blood 103:868-77. 2004
    ....
  34. ncbi The role of T-lymphocyte subsets and interleukin-5 blood levels among Indian subjects with autoimmune thyroid disease
    Sripathy Gopalakrishnan
    Defence Bio engineering and Electromedical Laboratory, Bangalore, India
    Hormones (Athens) 9:76-81. 2010
    ..AITD is being increasingly reported among the Indian population. Lymphocyte subsets and levels of interleukin-5 (IL- 5) were studied in the peripheral blood of patients with AITD...
  35. pmc Src homology 2 protein tyrosine phosphatase (SHPTP2)/Src homology 2 phosphatase 2 (SHP2) tyrosine phosphatase is a positive regulator of the interleukin 5 receptor signal transduction pathways leading to the prolongation of eosinophil survival
    K Pazdrak
    University of Texas Medical Branch, Department of Internal Medicine, Allergy and Immunology Division, Galveston, TX 77555 0762, USA
    J Exp Med 186:561-8. 1997
    ....
  36. ncbi Strongyloides ratti: the role of interleukin-5 in protection against tissue migrating larvae and intestinal adult worms
    K Watanabe
    Department of Parasitology, Institute of Tropical Medicine, Nagasaki University, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    J Helminthol 77:355-61. 2003
    ..Intestinal worms were not found in mAb treated mice or in control mice after oral implantation of adult worms. Eosinophils were therefore mainly involved in protection against tissue migrating worms in secondary infections...
  37. doi Effects of antisense interleukin-5 gene transferred by recombinant adeno-associated virus to allergic rats
    Daxiong Zeng
    Department of Respiratory Medicine, Tongji Hospital, Key Laboratory of Pulmonary Diseases of Ministry of Health of China, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Respirology 15:132-40. 2010
    ..This study explored a new approach to asthma therapy in which allergic rats were transfected with the IL-5 antisense gene delivered by the recombinant adeno-associated virus (rAAV-ASIL-5)...
  38. pmc Eosinophil recruitment into the respiratory epithelium following antigenic challenge in hyper-IgE mice is accompanied by interleukin 5-dependent bronchial hyperresponsiveness
    S Y Eum
    Unite de Pharmacologie Cellulaire, Unité Associée Institut Pasteur Institut National de la Santé et de la Recherche Médicale 285, Paris, France
    Proc Natl Acad Sci U S A 92:12290-4. 1995
    ..b>Interleukin 5 (IL-5) titers in serum and bronchoalveolar lavage fluid of BP2 mice were augmented by the antigenic ..
  39. pmc Interleukin 5 (IL-5) is not required for expression of a Th2 response or host resistance mechanisms during murine schistosomiasis mansoni but does play a role in development of IL-4-producing non-T, non-B cells
    L R Brunet
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    Infect Immun 67:3014-8. 1999
    ..The absence of IL-5 failed to affect the induction of Th2 responses in naive mice. Peritoneal exudate cells recovered from egg-injected IL-5(-/-) or WT mice produced equivalent levels of IL-4 following restimulation with SEA or anti-CD3...
  40. ncbi Peptide nucleic acids are potent modulators of endogenous pre-mRNA splicing of the murine interleukin-5 receptor-alpha chain
    J G Karras
    Department of Molecular and Cellular Pharmacology, Isis Pharmaceuticals, Incorporated, 2292 Faraday Avenue, Carlsbad, California 92008, USA
    Biochemistry 40:7853-9. 2001
    ..The pronounced activity of antisense PNAs in modulating IL-5Ralpha mRNA splicing observed in our study identifies these compounds as a promising new class of lower molecular weight splicing modulators...
  41. pmc Pimecrolimus reduces eosinophil activation associated with calcium mobilization
    Douglas A Plager
    Allergic Diseases Research Laboratory, Department of Dermatology, Mayo Clinic, Guggenheim 4 94, 200 First Street Southwest, Rochester, MN 55905, USA
    Int Arch Allergy Immunol 149:119-26. 2009
    ..However, its effects on eosinophils, a cell type implicated in allergic disease pathology, are unknown. Therefore, we examined the effects of pimecrolimus on eosinophil superoxide anion production, degranulation and survival...
  42. doi Pharmacokinetics and pharmacodynamics of mepolizumab, an anti-interleukin-5 monoclonal antibody
    Deborah A Smith
    Clinical Pharmacology Modeling and Simulation, GlaxoSmithKline, Research Triangle Park, North Carolina 27709 3398, USA
    Clin Pharmacokinet 50:215-27. 2011
    ..The estimated maximal decrease in eosinophil count was approximately 85% from baseline and the half-maximal inhibitory concentration (IC50) was approximately 0.45 μg/mL...
  43. pmc Sequential mutations in the interleukin-3 (IL3)/granulocyte-macrophage colony-stimulating factor/IL5 receptor beta-subunit genes are necessary for the complete conversion to growth autonomy mediated by a truncated beta C subunit
    J Hannemann
    Abteilung der Zell und Virusgenetik, Heinrich Pette Institut für Experimentelle Virologie und Immunologie, Hamburg, Germany
    Mol Cell Biol 15:2402-12. 1995
    ..Implications for both leukemogenic progression and receptor-subunit interaction and signaling are discussed...
  44. ncbi Chromosomal localization and organization of the murine genes encoding the beta subunits (AIC2A and AIC2B) of the interleukin 3, granulocyte/macrophage colony-stimulating factor, and interleukin 5 receptors
    D M Gorman
    Department of Molecular Biology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, California 94304
    J Biol Chem 267:15842-8. 1992
    ..Isolation of various forms of AIC2 cDNAs reveals differential splicing of the transcripts...
  45. ncbi Isolation, structure and expression of cDNA and genomic clones for murine eosinophil differentiation factor. Comparison with other eosinophilopoietic lymphokines and identity with interleukin-5
    H D Campbell
    John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory
    Eur J Biochem 174:345-52. 1988
    b>Eosinophil differentiation factor (EDF) is a recently described regulator affecting eosinophil growth and activation. cDNA clones for murine EDF were isolated by direct expression from libraries prepared from the T cell hybrid NIMP-TH1...
  46. ncbi Mechanisms regulating the mRNA levels of interleukin-5 and two other coordinately expressed lymphokines in the murine T lymphoma EL4.23
    H Naora
    Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra
    Blood 83:3620-8. 1994
    ..Furthermore, IL-5 mRNA was more stable than IL-2 and GM-CSF mRNAs. These latter two species were stabilized by cycloheximide, suggesting that a labile mechanism may regulate their degradation...
  47. ncbi The conserved lymphokine element-0 in the IL5 promoter binds to a high mobility group-1 protein
    J Marrugo
    Division of Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, U S A
    Mol Immunol 33:1119-25. 1996
    ..It also binds to the CLE0 elements of IL4, GMCSF and GCSF genes. CLEBP-1 and closely related HMG-1 and HMG-2 proteins may play key roles in facilitating the expression of the lymphokine genes that contain CLE0 elements...
  48. ncbi The solution structure of the cytokine-binding domain of the common beta-chain of the receptors for granulocyte-macrophage colony-stimulating factor, interleukin-3 and interleukin-5
    T D Mulhern
    Department of Biochemistry, University of Adelaide, Adelaide, 5005, Australia
    J Mol Biol 297:989-1001. 2000
    ..The elucidation of the structure of the cytokine-binding domain of the beta-chain provides insight into the cytokine-dependent and factor-independent activation of the receptor...
  49. ncbi Enhanced soluble interleukin-5 receptor alpha expression in nasal polyposis
    P Gevaert
    Department of Otorhinolaryngology, Ghent University Hospital, Belgium
    Allergy 58:371-9. 2003
    ..Given the key role of IL-5 in eosinophil function, we investigated SOL IL-5Ralpha expression pattern in an eosinophil-associated disease such as nasal polyposis (NP)...
  50. pmc Increased expression of interleukin-5 (IL-5), IL-13, and tumor necrosis factor alpha genes in intestinal lymph cells of sheep selected for enhanced resistance to nematodes during infection with Trichostrongylus colubriformis
    Anton Pernthaner
    AgResearch Limited, Wallaceville Animal Research Center, P O Box 40063, Ward St, Upper Hutt, New Zealand
    Infect Immun 73:2175-83. 2005
    ..Genes or alleles that predispose an animal to develop this type of response appear to have segregated with the R selection line and may contribute to the increased resistance of these animals...
  51. pmc Molecular cloning and expression of the murine interleukin-5 receptor
    S Takaki
    Department of Biology, Kumamoto University Medical School, Japan
    EMBO J 9:4367-74. 1990
    ..Homology search for the amino acid sequence of the IL-5 receptor reveals that the IL-5 receptor contains a common motif of a cytokine receptor family that is recently identified...
  52. ncbi Isolation and characterization of marsupial IL5 genes
    R J Hawken
    Centre for Animal Biotechnology, The University of Melbourne, Parkville, Victoria, Australia
    Immunogenetics 49:942-8. 1999
    The genomic nucleotide sequence and chromosomal position of the interleukin 5 (IL5) gene has been described for the model marsupial Macropus eugenii (tammar wallaby)...
  53. ncbi Molecular cloning, expression, and purification of pig interleukin-5
    H Sylvin
    Department of Laboratory Medicine, Division of Clinical Immunology, Karolinska Hospital, SE 17176 Stockholm, Sweden
    Immunogenetics 51:59-64. 2000
    ..Pig IL-5 shows 65% amino acid identity to the human IL-5 sequence and 90, 88, 83, 62, and 61% identity to the cow, sheep, horse, mouse, and rat counterparts...
  54. ncbi Modified peptide antagonists of interleukin 5 exhibit extended in vivo persistence but restricted species specificity
    I J Uings
    Department of Cell Biology, GlaxoWellcome Research and Development, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK
    Cytokine 15:10-9. 2001
    ..peptide with 19 amino acids in each chain that antagonises the action of the eosinophil-specific cytokine, interleukin 5 (IL-5)...
  55. ncbi Effect of a novel interleukin-5 receptor antagonist, YM-90709 (2,3-dimethoxy-6,6-dimethyl-5,6-dihydrobenzo[7,8]indolizino[2,3-b]quinoxaline), on antigen-induced airway inflammation in BN rats
    Tatsuaki Morokata
    Inflammation Research Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, 21 Miyukigaoka, Tsukuba, Ibaraki 305 8585, Japan
    Int Immunopharmacol 4:873-83. 2004
    ....
  56. ncbi A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma
    Patrick Flood-Page
    F R C P, London Chest Hospital, Bonner Road, London E2 9JX, UK
    Am J Respir Crit Care Med 176:1062-71. 2007
    ..A previous small dose-finding study found that mepolizumab, a humanized anti-interleukin-5 monoclonal antibody, had no effect on allergen challenge in humans...
  57. doi Anti-interleukin-5 antibody treatment (mepolizumab) in active eosinophilic oesophagitis: a randomised, placebo-controlled, double-blind trial
    A Straumann
    Department of Gastroenterology, Kantonsspital, Olten, Switzerland
    Gut 59:21-30. 2010
    ..The pharmacodynamic effect of mepolizumab (a humanised anti-interleukin-5 monoclonal antibody) in EoO was evaluated...
  58. doi Interleukin-5 and interleukin-10 are produced in central nervous system tumor cysts
    Qiang Li
    Department of Neurosurgery, Kansai Medical University, 10 15 Fumizono cho, Moriguchi City, Osaka 570 8506, Japan
    J Clin Neurosci 16:437-40. 2009
    ..Therefore, the local production of interleukin-5 and interleukin-10 might be implicated in some types of cyst formation...
  59. ncbi The murine interleukin-5 receptor alpha-subunit gene: characterization of the gene structure and chromosome mapping
    F Imamura
    Department of Cell Differentiation, Kumamoto University School of Medicine, Japan
    DNA Cell Biol 13:283-92. 1994
    ..By fluorescence in situ hybridization analysis, the mIL-5R alpha gene has been assigned to chromosome 6...
  60. pmc Frequencies of interleukin-5 mRNA-producing cells in healthy individuals and in immunoglobulin-deficient patients, measured by in situ hybridization
    C I Smith
    Department of Clinical Immunology, Novum, Karolinska Institute, Huddinge Hospital, Sweden
    Clin Exp Immunol 81:417-22. 1990
    ..44%) and 20 patients (mean 0.58%). Thus, although IL-5 has been reported to be an important regulator of IgA synthesis, a defect production does not seem to be the underlying mechanism in human immunoglobulin deficiency...
  61. pmc Molecular basis of the membrane-anchored and two soluble isoforms of the human interleukin 5 receptor alpha subunit
    J Tavernier
    Roche Research Gent, Belgium
    Proc Natl Acad Sci U S A 89:7041-5. 1992
    ..cDNA clones were isolated spanning the transmembrane region and a complete cytoplasmic domain of the human interleukin 5 receptor alpha subunit (hIL5R alpha)...
  62. ncbi Multiple tyrosine residues in the intracellular domain of the common beta subunit of the interleukin 5 receptor are involved in activation of STAT5
    T B van Dijk
    Department of Pulmonary Diseases, University Hospital Utrecht, Netherlands
    FEBS Lett 412:161-4. 1997
    ....
  63. ncbi Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons
    G G Loots
    Genome Sciences Department, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Science 288:136-40. 2000
    ..Characterization of the largest element in yeast artificial chromosome transgenic mice revealed it to be a coordinate regulator of three genes, interleukin-4, interleukin-13, and interleukin-5, spread over 120 kilobases...
  64. ncbi SCID mice show a similar susceptibility to Angiostrongylus cantonensis as do wild-type mice of the C.B-17 strain
    K Yoshimura
    Department of Parasitology, Akita University School of Medicine, Japan
    Parasitol Res 86:542-50. 2000
    ..b>Interleukin 5 (IL-5) production in +/+ mice is similar to that in BALB/c and C57BL/6 mice...
  65. ncbi Interleukin-5 inhibition of biliary cell chloride currents and bile flow
    J M McGill
    Roudebush Veterans Affairs Medical Center, Herman B Wells Center for Pediatric Research, Riley Hospital for Children, Indiana, USA
    Am J Physiol Gastrointest Liver Physiol 280:G738-45. 2001
    ..Since IL-5 has previously been associated with cholestatic liver disease, we speculate that IL-5 may contribute to liver injury through its effects on biliary secretion...
  66. ncbi CD4(+) T cell-dependent airway mucus production occurs in response to IL-5 expression in lung
    J Paul Justice
    Divisions of Hematology Oncology, Department of Biochemistry and Molecular Biology, Mayo Clinic Scottsdale, Scottsdale, Arizona 85259, USA
    Am J Physiol Lung Cell Mol Physiol 282:L1066-74. 2002
    ....
  67. ncbi Measurement of changes in mRNA for IL-5 in noninvasive scrapings of nasal epithelium taken from patients undergoing nasal allergen challenge
    Stephen C Dreskin
    Department of Medicine, Division of Allergy, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Campus Box B164, Denver 80262, USA
    J Immunol Methods 268:189-95. 2002
    ..in increased numbers of inflammatory cells and increased production of pro-inflammatory cytokines including interleukin 5 (IL-5)...
  68. ncbi Allergen-induced accumulation of airway dendritic cells is supported by an increase in CD31(hi)Ly-6C(neg) bone marrow precursors in a mouse model of asthma
    Leonie S van Rijt
    Department of Pulmonary and Critical Care Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    Blood 100:3663-71. 2002
    ..precursors also expressed the eotaxin receptor CCR3 and differentiated into eosinophils when grown in interleukin 5. Serum levels of eotaxin were doubled in mice with inflammation...
  69. ncbi Eosinophilic major basic protein and interleukin-5 in eosinophilic myositis
    K Murata
    Department of Neurology, Nara Medical University, Nara, Japan
    Eur J Neurol 10:35-8. 2003
    ..These results suggest that IL-5 induces local accumulation of eosinophils and their release of MBP. The secreted proteins adhere to the muscle fiber membrane, resulting in muscle damage...
  70. ncbi Time-resolved fluorescence measurements using microlens array and area imaging devices
    Susanne Merk
    Boehringer Ingelheim Pharma GmbH and Co KG, Department of Integrated Lead Discovery, Birkendorfer Strasse 65, D 88397 Biberach an der Riss, Germany
    Comb Chem High Throughput Screen 7:45-54. 2004
    Time-resolved fluorescence (TRF) assay formats are frequently used technologies in high-throughput screening...
  71. ncbi Symptoms defined by parents' and teachers' ratings in attention-deficit hyperactivity disorder: changes with age
    Bedriye Oncu
    Psychiatry Department, Ankara University Faculty of Medicine, Turkey
    Can J Psychiatry 49:487-91. 2004
    To determine whether Child Behavior Checklist/4-18 (CBCL) and Teacher Report Form (TRF) scores of children and adolescents with a first-time diagnosis of attention-deficit hyperactivity disorder (ADHD) are different and whether there is ..
  72. pmc Persistent HIV-1 replication does not explain low levels of T-cell interferon-gamma mRNA and elevated serum NO(2) (-)/NO(3) (-) in patients with stable CD4 T-cell responses to HAART
    S Lee
    Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, Perth, Western Australia
    Clin Exp Immunol 138:110-5. 2004
    ..These data indicate a persistent immune deficit in immune reconstituted patients irrespective of HIV viral load and associate persistent viral replication with lymphocyte activation, probably involving CD8 T-cells...
  73. ncbi [Relationship between GATA-3 and IL-4 and IL-5 in patients with allergic rhinitis]
    Hua Bin Li
    Department of Otorhinolaryngology, Jiangsu Province Hospital, Nanjjing 210029, China
    Zhonghua Er Bi Yan Hou Ke Za Zhi 39:479-82. 2004
    ..To evaluate the relationship between GATA-3 and IL-4, IL-5 in patients with allergic rhinitis...
  74. ncbi Characterization of the T-cell response in a patient with phenindione hypersensitivity
    Dean J Naisbitt
    Department of Pharmacology, The University of Liverpool, England
    J Pharmacol Exp Ther 313:1058-65. 2005
    ..Our data show that CD4(+) T-cells are involved in the pathophysiology of phenindione hypersensitivity. There may be cross-sensitivity with warfarin in some phenindione hypersensitive patients...
  75. ncbi JTP-27536 [(+)-1,3-dihydroxy-2-hydroxymethylpropyl-2-ammonium 2-[(R)-3-cyclo-hexyl-1-phenylpropyl]-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylate monohydrate], a novel inhibitor of immunoglobulins and interleukin-5 with anti-inflammatory properties in m
    Takayuki Mimura
    Japan Tobacco Inc, Central Pharmaceutical Research Institute, 1 1 Murasaki cho, Takatsuki, Osaka 569 1125, Japan
    J Pharmacol Exp Ther 314:293-301. 2005
    ....
  76. doi Eosinophilic colitis in a patient with advanced transitional cell carcinoma of the bladder: a paraneoplastic syndrome?
    Mehtap Erkmen Uyar
    Department of Internal Medicine, Gastroenterology, and Radiology, Faculty of Medicine, Fatih University, Ankara, Turkey
    Am J Med Sci 336:81-3. 2008
    ..To our knowledge, eosinophilic colonic infiltration as a manifestation of transitional cell bladder carcinoma has not been previously reported...
  77. doi Significant elevation of a Th2 cytokine, interleukin-10, in pelvic inflammatory disease
    Kuo Shuen Chen
    Department of Internal Medicine, Institute of Medicine, Chung Shan Medical University, Chung Shan Medical University Hospital, Taichung, Taiwan
    Clin Chem Lab Med 46:1609-16. 2008
    ....
  78. pmc Identification of DNA regions and a set of transcriptional regulatory factors involved in transcriptional regulation of several human liver-enriched transcription factor genes
    Hisashi Miura
    RIKEN Omics Science Center, RIKEN Yokohama Institute 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Nucleic Acids Res 37:778-92. 2009
    ..TRFs such as HNF1A, HNF3A, HNF3B, HNF3G and HNF4A resulted in perturbation of the expression of several single TRF genes, such as HNF1A, HNF3G and CEBPA genes...
  79. pmc The peptidyl-prolyl isomerase Pin1 facilitates cytokine-induced survival of eosinophils by suppressing Bax activation
    Zhong Jian Shen
    Waisman Center for Developmental Disabilities, The Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53705, USA
    Nat Immunol 10:257-65. 2009
    ..that in the absence of the prosurvival cytokines granulocyte-macrophage colony-stimulating factor and interleukin 5, Bax spontaneously underwent activation and initiated mitochondrial disruption...
  80. ncbi [A case of eosinophilic gastroenteritis with ascites and protein-losing gastroenteropathy]
    Eri Shiraishi
    Department of Internal Medicine, Hyogo Prefectural Nishinomiya Hospital
    Nihon Shokakibyo Gakkai Zasshi 106:1625-35. 2009
    ..It should be kept in mind that eosinophilic gastroenteritis is one of the causes of ascites...
  81. pmc Emerging therapies for severe asthma
    Neil C Thomson
    Respiratory Medicine, Institute of Infection, Immunity, and Inflammation, University of Glasgow, Glasgow, G12 OYN, UK
    BMC Med 9:102. 2011
    ....
  82. doi Amplification and noise properties of an erbium-doped multicore fiber amplifier
    K S Abedin
    OFS Laboratories, 19 Schoolhouse Road, Somerset, NJ 08873, USA
    Opt Express 19:16715-21. 2011
    A multicore erbium-doped fiber (MC-EDF) amplifier for simultaneous amplification in the 7-cores has been developed, and the gain and noise properties of individual cores have been studied...
  83. doi Anti-interleukin-5 antibody therapy in asthma and allergies
    Jonathan Corren
    Allergy Medical Clinic, Los Angeles, California, USA
    Curr Opin Allergy Clin Immunol 11:565-70. 2011
    b>Interleukin 5 (IL-5) has been shown to play an instrumental role in eosinophilic inflammation in allergic diseases...
  84. doi Anti-IL-5 immunomodulates the effect of Staphylococcus aureus enterotoxin on T cell response in nasal polyps
    S Langier
    Allergy and Clinical Immunology Unit, Tel Aviv University, Tel Aviv, Israel
    Rhinology 49:570-6. 2011
    ..we investigated the immunomodulatory effect of SAEs on cytokine production by T cell obtained from nasal polyps (NPs) and examined whether neutralizing interleukin 5 (IL-5) can reverse the immunological effect mediated by those toxins.
  85. doi The contribution of ergonomics to risk analysis in the design process: the case of a future control room
    Cecilia De la Garza
    Risk Management Department, 1 Av Général de Gaulle, Clamart, France
    Work 41:730-6. 2012
    ..has been conducted over the last 10 years through a Human Factors Engineering program at the French energy company EDF. A parallel has been drawn between a risk management process and this ergonomics process based on International ..
  86. doi A chemistry-based method to detect individual telomere length at a single chromosome terminus
    Takumi Ishizuka
    Research Center for Advanced Science and Technology RCAST, The University of Tokyo, 4 6 1 Komaba, Meguro ku, Tokyo 153 8904, Japan
    J Am Chem Soc 135:14-7. 2013
    ..Comparison of the DITL method and the traditional terminal restriction fragment (TRF) analysis indicates that the DITL approach appears to be promising for the quantification of telomere repeats in ..
  87. pmc Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages
    Ari B Molofsky
    Howard Hughes Medical Institute, University of California, San Francisco, San Francisco 94143, USA
    J Exp Med 210:535-49. 2013
    ..Thus, ILC2s are resident in VAT and promote eosinophils and AAM implicated in metabolic homeostasis, and this axis is enhanced during Th2-associated immune stimulation...
  88. doi Differential sensitivity of telomerase from human hematopoietic stem cells and leukemic cell lines to mild hyperthermia
    Abdolkhaleg Deezagi
    Department of Biochemistry, National Institute of Genetic Engineering and Biotechnology, Km 17, Karaj Tehran Freeway, Pajouhesh Blvd, P O Box 14155 6343, Tehran, Iran
    Cell Biochem Biophys 69:681-91. 2014
    ..collected and assayed for cell proliferation, viability, telomerase activity, and terminal restriction fragment (TRF) lengths. The enzyme activity from HSCs was decreased up to 68.6 at 42 and 85.1 % at 43 °C for 120 min...
  89. ncbi [Effects of suplatast tosilate on airway inflammation and interleukin-5 in asthmatic rats]
    Dan Liu
    Department of Pediatrics, Hunan People s Hospital, Changcha 410005, China
    Zhongguo Dang Dai Er Ke Za Zhi 16:759-63. 2014
    ..To study the effects of suplatast tosilate (IPD) on the airway inflammation and expression of interleukin-5 in asthmatic rats...
  90. doi Verapamil modulates interleukin-5 and interleukin-6 secretion in organotypic human sinonasal polyp explants
    Benjamin S Bleier
    Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA
    Int Forum Allergy Rhinol 5:10-3. 2015
    ..The goal of this study was determine whether verapamil is capable of regulating cytokine secretion in sinonasal polyps and to compare this effect to dexamethasone, an established immunosuppressive corticosteroid...
  91. pmc Interleukin-5 facilitates lung metastasis by modulating the immune microenvironment
    Rinat Zaynagetdinov
    Division of Allergy, Department of Medicine, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University, Nashville, Tennessee
    Cancer Res 75:1624-34. 2015
    ....
  92. doi Climate-induced die-off affects plant-soil-microbe ecological relationship and functioning
    Francisco Lloret
    CREAF, E 08193 Cerdanyola del Vallès Barcelona, E 08193 Catalonia, Spain U Ecologia, Dept Biologia Animal, Biologia Vegetal i Ecologia, Universitat Autonoma Barcelona, E 08193 Cerdanyola del Vallès Barcelona, Spain
    FEMS Microbiol Ecol 91:1-12. 2015
    ..Vegetation diversity was positively related to TRF bacterial richness under unaffected canopies and was higher in diverse grassland...
  93. pmc Daily Eating Patterns and Their Impact on Health and Disease
    Amir Zarrinpar
    Regulatory Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA Division of Gastroenterology, University of California, San Diego, La Jolla, CA 92093, USA Electronic address
    Trends Endocrinol Metab 27:69-83. 2016
    ..Time-restricted feeding (TRF), during which time of access to food is restricted to a few hours, without caloric restriction, supports robust ..
  94. pmc Reslizumab in the management of poorly controlled asthma: the data so far
    Diego Jose Maselli
    Department of Medicine, Division of Pulmonary Diseases and Critical Care, University of Texas Health Science Center at San Antonio, San Antonio, TX
    J Asthma Allergy 9:155-62. 2016
    ..3%) after exposure to reslizumab. Future surveillance studies are still needed to establish the risks of malignancy and safety during pregnancy. ..
  95. pmc Spatially Explicit Modelling of the Belgian Major Endurance Event 'The 100 km Dodentocht'
    Steffie Van Nieuland
    KERMIT, Department of Mathematical Modelling, Statistics and Bioinformatics, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    PLoS ONE 11:e0164981. 2016
    ..For building the model, the empirical distribution functions (edf) of the marching speeds at every section of the trail in between two consecutive checkpoints and of the checkpoints ..
  96. doi Glucocorticoid receptor control of transcription: precision and plasticity via allostery
    Emily R Weikum
    Department of Biochemistry, Emory University School of Medicine, 1510 Clifton Road, Atlanta, Georgia 30322, USA
    Nat Rev Mol Cell Biol . 2017
    The glucocorticoid receptor (GR) is a constitutively expressed transcriptional regulatory factor (TRF) that controls many distinct gene networks, each uniquely determined by particular cellular and physiological contexts...
  97. ncbi Organization and chromosomal localization of the human interleukin 5 receptor alpha-chain gene
    T Tuypens
    Roche Research Gent, Belgium
    Eur Cytokine Netw 3:451-9. 1992
    ..This shows that all introns between the FN-III-like modules are of the +1 type, but in addition, splice sites within the Cys-module and WS-WS-module are invariably of the +2 and 0 type, respectively...
  98. ncbi Increase of soluble cytoadhesive molecules sE-selectin and sICAM-1 and hyperfibrinogenaemia in patients with polytrauma without septicaemia
    J Kvasnicka
    Department of Clinical Haematology, General University Hospital, Prague, Czech Republic
    Sb Lek 99:93-6. 1998
    ..698.3 +/- 54.4 versus control 255.6 +/- 58.0 g/l, p < 0.01) and a decrease of transferrin (Trf pts. 1.77 +/- 0.82 versus control 2.83 +/- 0.71 g/l, p < 0.01) were observed in this patients with polytrauma...
  99. ncbi The molecular defect in hypotransferrinemic mice
    C C Trenor
    Howard Hughes Medical Institute and Department of Pathology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Blood 96:1113-8. 2000
    Hypotransferrinemic (Trf(hpx/hpx)) mice have a severe deficiency in serum transferrin (Trf) as the result of a spontaneous mutation linked to the murine Trf locus...
  100. ncbi Multisite mutagenesis of interleukin 5 differentiates sites for receptor recognition and receptor activation
    C G Plugariu
    Department of Medicine, University of Pennsylvania School of Medicine, 909 Stellar Chance Laboratories, 422 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
    Biochemistry 39:14939-49. 2000
    Multisite mutagenesis of single-chain and monomeric forms of human interleukin 5 (IL-5) was performed to investigate mechanistic features of receptor activation and the possibility of differentiating sites of activation from those for ..
  101. ncbi Interleukin-1 beta, interleukin-5, interleukin-6, interleukin-8, and tumor necrosis factor-alpha in chronic sinusitis: response to systemic corticosteroids
    C M Lennard
    Division of Otolaryngology, Walter Reed Army Medical Center, Washington, DC, USA
    Am J Rhinol 14:367-73. 2000
    ....

Research Grants80

  1. PATRICIA CHANDHOK FULKERSON; Fiscal Year: 2015
    ..This proposal will provide key information with clinical applications, especially given the eosinophil- targeted therapies that are currently under avid development. ..
  2. Anti- IL5 therapy for Churg-Strauss Syndrome: a double blind randomized, placebo-
    Michael E Wechsler; Fiscal Year: 2010
    ....
  3. MECHANISMS OF PULMONARY FIBROSIS
    Sem H Phan; Fiscal Year: 2010
    ..abstract_text> ..
  4. Mechanisms of Virus-Induced Hyperreactivity in Atopics
    David B Jacoby; Fiscal Year: 2010
    ..In the course of these experiments, substances released by lung cells that contribute to asthma will be identified, and ways to block them will be tested. This will assist us in developing new treatments for asthma. ..
  5. Mouse models for the functional analysis of asthma-associated human polymorphisms
    Donata Vercelli; Fiscal Year: 2009
    ....
  6. Michael E Wechsler; Fiscal Year: 2016
    ....
  7. Daniela Cihakova; Fiscal Year: 2015
    ....
  8. Jonathan Savitz; Fiscal Year: 2016
    ....
  9. Involvement of Natural Killer T cells in Hepatic Fibrogenesis
    Ian N Hines; Fiscal Year: 2011
    ..Together, these studies will provide new insight into the mechanisms of T cell-mediated hepatic fibrosis. ..
  10. MOUSE MODEL OF EOSINOPHIL MEDIATED SKIN PATHOLOGY
    James Lee; Fiscal Year: 1999
    DESCRIPTION (from the application): Interleukin 5 (IL-5) has been shown to be an important component of the cytokine regulatory network that controls peripheral eosinophil numbers and their recruitment/survivability at sites of ..
  11. Early Environmental Hygiene and Pediatric Asthma
    Christine C Johnson; Fiscal Year: 2009
    ..If factors associated with animal or endotoxin contact are related to asthma risk, such factors would likely lend themselves to public health interventions. ..
  12. IL3,IL5, and GM-CSF Signaling and Asthma
    Christian Schindler; Fiscal Year: 2004
    ..Specifically we propose to: 1. Further characterize StIP1. 2. Functionally characterize the STAT four-bundle-helix. 3. Explore the role of Stat5 signal decay in primary leukocytes. ..
  13. Pandurangan Vijayanand; Fiscal Year: 2015
    ..They will have a broad impact on our understanding of asthma, and set an important precedent for investigating the role of epigenetic mechanisms in other immune-mediated disorders. ) ..
  14. Anjana Rao; Fiscal Year: 2014
    ..In this proposal we plan to investigate the role of TET proteins in T cells, a major class of cells in the immune system that protect the organism from attack by bacteria, viruses and other pathogens including cancer cells. ..
  15. INTERLEUKIN 5 GENE EXPRESSION AND LUNG INFLAMMATION
    Anuradha Ray; Fiscal Year: 2000
    ..The expression of this gene will be determined in antigen and virus models of airway inflammation in the presence or absence of glucocorticoids. ..
  16. Peroxidase-Based Toxicity In Hypereosinophilic States.'
    Arne Slungaard; Fiscal Year: 2006
    ..e., dietary supplementation with inexpensive SCN-), that could be applied even in impoverished communities as well as against more common allergic diseases, such as asthma. ..
  17. RELATIONSHIP BETWEEN ALLERGIC RHINITIS AND SINUSITIS
    Fuad Baroody; Fiscal Year: 2003
    ..We hypothesize that histamine, leukotrienes and interleukin 5 produced into the nose and the maxillary sinus will be important for the generation of the eosinophilic ..
  18. IMMUNE RESPONSE DURING ENTERIC INFLAMMATORY DISEASE
    Michael Wannemuehler; Fiscal Year: 1993
    ..T cells from control and infected mice will be analysed for the production of gamma interferon (IFN-g) or interleukin 5 (IL 5)...
  19. PINWORM: A SELF TOLERANCE AND AUTOIMMUNE DISEASE MODIFIE
    Kenneth Tung; Fiscal Year: 2001
    ..In summary, with this hypothesis-driven proposal, we will explore a common and natural infectious agent and its capacity to terminate self tolerance and provoke autoimmune disease in neonatal mice. ..
  20. ACTIVATED MUTANTS AS PROBES OF GM-CSF RECEPTOR FUNCTION
    RICHARD D ANDREA; Fiscal Year: 2003
    ..In addition, it is proposed that novel reagents (eg. monoclonal antibodies) can be generated which interact with critical regions of hbetac and can trigger signalling activity in the absence of cytokine. ..
  21. REGULATION OF THL RESPONSES IN PULMONARY SARCOIDOSIS
    DAVID MOLLER; Fiscal Year: 2000
    ..Thus, these studies may assist in the development of new therapies designed to halt the granulomatous and fibrotic responses that lead to end-stage pulmonary disease in sarcoidosis. ..
  22. IMMUNOSUPPRESSION BY AN INHIBITOR OF INTERLEUKIN 2
    MARTHA CATHCART; Fiscal Year: 1991
    ..These studies will greatly enhance our knowledge of what HSF is, how it mediates immunosuppression in vitro and will give us an indication of its potential as an immunotherapeutic agent in transplantation and autoimmunity...
  23. MECHANISMS OF PULMONARY FIBROSIS
    Sem Phan; Fiscal Year: 2000
    ....
  24. Stress and Immunity in Pediatric Asthma
    Jack Nassau; Fiscal Year: 2004
    ..Techniques of analysis of variance with repeated measures and multiple regression will be used. Results will further our knowledge of the relationships between stress and immunity in asthma. ..
  25. Regulation of Interleukin-5 Receptor Signaling
    MAGARITA MARTINEZ MOCZYGEMBA; Fiscal Year: 2003
    ..In addition, eosinophils from IL-5 transgenic mice will be isolated and analyzed for their ability to be further stimulated by GM-CSF or IL-3 in vitro. ..
  26. Structural Mechanism of IL5-Receptor Subunit Recruitment
    Irwin Chaiken; Fiscal Year: 2004
    ..provided by applicant): The objective of this continuation application is to elucidate the mechanism of human interleukin 5 receptor recognition at the molecular and structural levels...
  27. STRUCTURE BASED DESIGN OF NOVEL IL5 RECEPTOR ANTAGONISTS
    HENGYI ZHU; Fiscal Year: 1999
    ..the goal of phase 2 activities aimed at refinement of the initial leads into qualified pre-clinical candidates for IL-5 antagonism PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE ..
  28. INTERLEUKIN 5 RECEPTOR RECOGNITION, MIMETICS, ANTAGONISM
    Irwin Chaiken; Fiscal Year: 2004
    ..And it will yield antagonist strategies which could lead to molecular tools for therapeutic intervention in asthma and other allergic diseases. ..
  29. The Signal Transduction Mechanism of Interleukin-5
    Rafeul Alam; Fiscal Year: 2005
    ..Lyn and IRIP may represent excellent therapeutic targets for intervention in asthma and other allergic diseases. ..
  30. Proteasome Regulation of Interleukin-5 Receptor Endocytosis
    MAGARITA MARTINEZ MOCZYGEMBA; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  31. ROG--A NOVEL PROTEIN THAT REGULATES TH2 CYTOKINES
    I cheng Ho; Fiscal Year: 2003
    ....
  32. STRUCTURE BASED DESIGN OF NOVEL INTERLEUKIN-5 RECEPTOR
    HENGYI ZHU; Fiscal Year: 2002
    ..The long term goal of this project is to develop at least one non-peptide IL-5 receptor antagonist as a potential anti-asthmatic and anti-allergic agent. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE ..
  33. MECHANISMS OF EOSINOPHIL ASSOCIATED INFLAMATION
    Gerald Gleich; Fiscal Year: 2000
    ....
  34. MODULATION OF IL-5 MEDIATED INFLAMMATION
    DAVID HUSTON; Fiscal Year: 2006
    ..abstract_text> ..
  35. Bibo Li; Fiscal Year: 2016
    ..Identification of novel factors involved in antigenic variation also provides more potential targets for anti-parasite drugs and helps for eventual elimination of this parasite. ..
  36. Genomic Instability and Senescence in Cancer
    Lynne Elmore; Fiscal Year: 2009
    ..approaches will be employed to define (1) the involvement of topoisomerase ll-mediated telomere breakage and TRF-2 deregulation in adriamycin-induced telomere dysfunction and senescence;(2) TRF2 modifications in breast tumor ..
  37. Structural Studies of RNA Maturation and Processing
    Christopher D Lima; Fiscal Year: 2013
    ..TRAMP components by expressing, purifying, and reconstituting complexes that contain the Mtr4 RNA helicase, the Trf poly(A) polymerases and the Air RNA binding proteins...
  38. Felix W Wehrli; Fiscal Year: 2014
    ..the tools available for detecting the earliest presymptomatic changes, brought about by endothelial dysfunction (EDF), are unsatisfactory...
  39. MICHAEL LANGHAM; Fiscal Year: 2016
    ..multiple parameters, as part of a single one-hour examination, to detect early signs of endothelial dysfunction (EDF). Early detection of EDF is vital as it promotes pathogenesis of atherosclerosis, a primary contributor to CVD...
  40. Shared Instrumentation: Amnis ImageStream System
    Lesleyann Hawthorn; Fiscal Year: 2010
    ..This also holds true for accuracy in gating strategies. With the introduction of Extended Depth of Field (EDF) technology, the ImageStream can also generate confocal-like images...
  41. mazEF-mediated programmed cell death network in E. coli
    Hanna Engelberg Kulka; Fiscal Year: 2010
    ..to extend our research by a comprehensive characterization of a novel quorum sensing Extra-cellular Death Factor (EDF) that we were excited to discover as being a signaling peptide molecule required for E...
  42. VICTOR ANDREW STENGER; Fiscal Year: 2016
    ..methods were developed for correcting image artifacts using "parallel transmission" (PTX) and "tailored RF" (TRF) pulses. These artifacts include RF field (B1+) inhomogeneity and susceptibility artifacts (B0 inhomogeneity)...
  43. Gene Regulation by Myb Proteins
    Joseph Lipsick; Fiscal Year: 2005
    ..g., swl3, isw1. ada2. n-cor, rebi, rap1, trf, taz)...
  44. HTS Assay Development for Modulators of a Nuclear Import/Export Switch
    ISABELLA GRAEF; Fiscal Year: 2007
    ..first specific aim proposed in this application is to develop an in vitro multianalyte time resolved fluorescence (TRF) assay, which allows a quantitative assessment of the interaction of recombinant NFATc protein with the nuclear ..
  45. CHILDHOOD EPILEPSY--FACTORS AFFECTING ADAPTATION
    Joan Austin; Fiscal Year: 1999
    ..using the Child Behavior Checklist's (CBCL) Parent Form, Youth Self-Report form (YSR), and Teacher's Report form (TRF), as well as the Child Depression Inventory (CDI), and the Piers- Harris Self-Concept Scale...
  46. Novel Assays to Identify HIV Vif Inhibitors
    Dana Gabuzda; Fiscal Year: 2006
    ..In preliminary studies, we developed TRF and FRET assays for Vif-A3G binding and cell based assays for Vif-mediated degradation of A3G...
  47. Open, Flexible Platform for CAM Adherence Monitoring and Mind-Body Investigations
    K JEFFREY ERIKSEN; Fiscal Year: 2006
    ..experienced managing collected data files and also add support for standard biological data file formats such as EDF. [unreadable] [unreadable] Aim 4. Test the system on human subjects...
  48. Advancing ADHD diagnosis via standardized observations
    STEPHANIE MCCONAUGHY; Fiscal Year: 2006
    ..Teachers will complete the ADHDRS-IV-School version, Teacher's Report Form (TRF), SSRS, and Academic Performance Rating Scale (APRS)...
  49. ACTIVATION AND SENESCENCE OF HELPER T LYMPHOCYTES
    Doris Tse; Fiscal Year: 2001
    ..context of conventional multicolor immunocytometry by FACS to determine telomeric terminal restriction fragment (TRF) length, which is a direct reflection of T cell mitotic history and proliferative potential...
  50. NATURALLY OCCURRING DELAYED-TYPE ISO-HYPERSENSITIVITY
    JACK BATTISTO; Fiscal Year: 1980
    ..correlates with the capacity of the cells to interact in an in vitro antibody system with T cell helper factor (TRF). Thus, this membrane structure may be a receptor for TRF...
  51. THE HYPEREOSINOPHILIC SYNDROMES AND MEPOLIZUMAB
    Gerald Gleich; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  52. Eosinophil Granule Proteins and Their Functions
    Gerald Gleich; Fiscal Year: 2006
    ..Overall, these studies will expand our knowledge of the molecules composing the eosinophil granule and provide new tools to dissect eosinophil function in disease. ..
  53. Global Gene Expression in Chronic Rhinosinusitis
    DOUGLAS PLAGER; Fiscal Year: 2005
    ..These new molecular approaches should shed light on the mechanisms of CRS and open novel avenues for diagnosis and treatment of this difficult disease. ..
  54. Adducin and the Membrane Skeleton
    LUANNE PETERS; Fiscal Year: 2007
    ..Follow up studies will include electrocardiology and echocardiology. ..
  55. K-DEPENDENT NA/CA EXCHANGE IN HUMAN PLATELETS
    Masayuki Kimura; Fiscal Year: 2003
    ..Findings of this project might identify previously unknown cardiovascular effects of dietary Na and K, thereby revealing a new dimension of 'salt sensitivity' in human beings. ..
  56. Avian models for aging: telomeres and oxidative damage
    Carol Vleck; Fiscal Year: 2003
    ..abstract_text> ..
  57. Human Telomere Genetics
    Abraham Aviv; Fiscal Year: 2008
    ..Results will serve to define genes as determinants of telomere length. Such information would lead to new diagnostic and therapeutic approaches to treat age-related diseases. ..
  58. Mucosal Lymphocyte Homing in the Head and Neck
    David Pascual; Fiscal Year: 2008
    ..n. challenge with CT. From this work, we will learn how routes of immunizations can be used to effectively target vaccines to nonintestinal mucosal sites. ..
  59. TRANSGENIC/KNOCKOUT ANIMALS IN MYOCARDIAL PRESERVATION
    DIPAK DAS; Fiscal Year: 2008
    ..The results of this proposed research will hopefully increase our understanding of redox regulation by Trx/Grx in the ischemic myocardium. [unreadable] [unreadable]..
  60. IMMUNE RESPONSE IN THE LUNG TO TB PROTEINS IN AIDS
    William Rom; Fiscal Year: 2002
    ..tb. proteins in PBMCs and BAL. This proposal will provide critical information on memory immunity in the lung when humans are infected/exposed to M. tb. and how this "protective" immune response to TB may be perturbated in AIDS. ..
  61. RSV AND ASTHMA
    David Broide; Fiscal Year: 2003
    ..Overall these studies will contribute to our understanding of the mechanism of eosinophilic inflammation during RSV infection and suggest candidate vaccine strategies to inhibit RSV infection and airway inflammation. ..
  62. CHILD AND FAMILY THERAPY FOR ANXIETY-DISORDERED YOUTH
    PHILIP KENDALL; Fiscal Year: 2004
    ..Examinations of clinical significance, predictors of treatment outcome, and differential responsiveness to the two treatments will be conducted. ..
  63. Chronological Age-Dependent Genomic Instability in Yeast
    Valter D Longo; Fiscal Year: 2010
    ..Thus, chronologically aging S. cerevisiae can serve as a model to identify genes that regulate genomic instability and understand the mechanisms responsible for age-dependent DNA mutations and cancer in mammals. ..
  64. Immune Correlates of HSV-2 Disease Severity
    David Koelle; Fiscal Year: 2007
    ....
  65. Mouse Models for Heart, Lung and Blood Disease
    LUANNE PETERS; Fiscal Year: 2007
    ..New mouse models will be cryo-preserved in order to maintain their availability. Provision are likewise to maintain all JAX PGA resources beyond the PGA program. ..
  66. Use of Herbs and Dietary Supplements in Four Ethnicities
    Annette Fitzpatrick; Fiscal Year: 2005
    ..It may also be possible to test associations of specific herb/supplement use with specific clinical/subclinical conditions should adequate power be available. ..
  67. FTI Biology & Treatment of Myeloproliferative Disorders
    Jason Gotlib; Fiscal Year: 2005
    ..If clinically efficacious, further studies of R115777 in MPDs will be warranted...
  68. DEVELOPMENTAL TWIN STUDY: ATTENTION, AGGRESSION, AFFECT
    JAMES HUDZIAK; Fiscal Year: 2004
    ..To these data, he will add parent (CBCL and Parent Rating Scale- CPRS) and teacher reports (Teacher's Report Form- TRF, and Conners' Teacher Rating Scale-CTRS) at ages 10 and 12...
  69. TARGETED DNA DELIVERY FOR SALIVARY IGA RESPONSES
    David Pascual; Fiscal Year: 2004
    ..These studies will provide the basis for future development of subunit vaccines to target the NALT for eliciting protective immunity in the oral cavity and SALT. ..
  70. Genomic Integrity, Aging, and Longevity
    Richard Cawthon; Fiscal Year: 2008
    ..Therefore, this research is likely to speed the development of medical interventions that slow aging and extend the duration of healthy adult life. [unreadable] [unreadable] [unreadable]..
  71. Telomeres and Vascular Aging
    Abraham Aviv; Fiscal Year: 2007
    ..abstract_text> ..
  72. Modulation of cytokine networks in mycoplasma pneumonia
    Jerry Simecka; Fiscal Year: 2004
    ..abstract_text> ..
  73. HSV Immunotherapeutic Vaccine
    David Koelle; Fiscal Year: 2005
    ....
  74. INNATE IMMUNITY IN HEART, LUNG, AND BLOOD DISEASE
    Fernando Martinez; Fiscal Year: 2003
    ..abstract_text> ..
  75. Preventive Intervention for Young Co-Parenting Couples
    Paul Florsheim; Fiscal Year: 2006
    ..abstract_text> ..
  76. Genetic Bases of Developmental Language Disorders
    Elena L Grigorenko; Fiscal Year: 2010
    ..abstract_text> ..
  77. MYOCARDIAL PRESERVATION DURING ISCHEMIC ARREST
    DIPAK DAS; Fiscal Year: 2009
    ..Ischemic heart disease represent the major cardiovascular related problems. Straitegies to reduce ischemic injury should improve the heart health leading to the reduction of death due to heart diseases. ..
  78. PHOSPHOLIPID SIGNALING IN MYOCARDIAL ISCHEMIC INJURY
    DIPAK DAS; Fiscal Year: 2009
    ....