integrin beta3

Summary

Gene Symbol: integrin beta3
Description: integrin subunit beta 3
Alias: BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, integrin beta-3, antigen CD61, integrin beta 3, integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61), platelet membrane glycoprotein IIIa
Species: human

Top Publications

  1. pmc Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin alphaIIbbeta3
    Naohide Watanabe
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Cell Biol 181:1211-22. 2008
  2. pmc HIV-1 inhibits autophagy in bystander macrophage/monocytic cells through Src-Akt and STAT3
    Jennifer Van Grol
    Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
    PLoS ONE 5:e11733. 2010
  3. pmc Sequential binding of αVβ3 and ICAM-1 determines fibrin-mediated melanoma capture and stable adhesion to CD11b/CD18 on neutrophils
    Pu Zhang
    Department of Bioengineering, The Pennsylvania State University, University Park, PA 16802, USA
    J Immunol 186:242-54. 2011
  4. ncbi Cell adhesion to fibrillin-1 molecules and microfibrils is mediated by alpha 5 beta 1 and alpha v beta 3 integrins
    Daniel V Bax
    United Kingdom Centre for Tissue Engineering, School of Biological Sciences, University of Manchester, United Kingdom
    J Biol Chem 278:34605-16. 2003
  5. pmc Platelet glycoprotein IIb/IIIa polymorphism HPA-3 b/b is associated with increased risk of ischemic stroke in patients under 60 years of age
    Hao Duan
    Department of Neurology, Shanghai 6th People s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China
    Med Sci Monit 18:CR19-24. 2012
  6. pmc Plasminogen activator inhibitor-1 regulates integrin alphavbeta3 expression and autocrine transforming growth factor beta signaling
    Benjamin S Pedroja
    Department of Ophthalmology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 284:20708-17. 2009
  7. pmc The integrin antagonist cilengitide activates alphaVbeta3, disrupts VE-cadherin localization at cell junctions and enhances permeability in endothelial cells
    Gian Carlo Alghisi
    Division of Experimental Oncology, Centre Pluridisciplinaire d Oncologie CePO, Faculty of Biology and Medicine, University of Lausanne, and NCCR Molecular Oncology, ISREC, Epalinges, Switzerland
    PLoS ONE 4:e4449. 2009
  8. ncbi The serpin PAI-1 inhibits cell migration by blocking integrin alpha V beta 3 binding to vitronectin
    S Stefansson
    Biochemistry Department, J H Holland Laboratory, American Red Cross, Rockville, Maryland 20855, USA
    Nature 383:441-3. 1996
  9. pmc Integrin alphaVbeta3 Binds to the RGD motif of glycoprotein B of Kaposi's sarcoma-associated herpesvirus and functions as an RGD-dependent entry receptor
    H Jacques Garrigues
    Department of Pathobiology, Box 357238, University of Washington, Seattle, WA 98195, USA
    J Virol 82:1570-80. 2008
  10. pmc Activated integrin alphavbeta3 cooperates with metalloproteinase MMP-9 in regulating migration of metastatic breast cancer cells
    Melanie Rolli
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:9482-7. 2003

Research Grants

Detail Information

Publications301 found, 100 shown here

  1. pmc Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin alphaIIbbeta3
    Naohide Watanabe
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Cell Biol 181:1211-22. 2008
    ..Thus, talin recruitment to alphaIIbbeta3 by RIAM mediates agonist-induced alphaIIbbeta3 activation, with implications for hemostasis and thrombosis...
  2. pmc HIV-1 inhibits autophagy in bystander macrophage/monocytic cells through Src-Akt and STAT3
    Jennifer Van Grol
    Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
    PLoS ONE 5:e11733. 2010
    ..The fact that pharmacologic manipulation of cell signaling restored autophagy in cells exposed to HIV-1-infected cells raises the possibility of therapeutic manipulation of cell signaling to restore autophagy in HIV-1 infection...
  3. pmc Sequential binding of αVβ3 and ICAM-1 determines fibrin-mediated melanoma capture and stable adhesion to CD11b/CD18 on neutrophils
    Pu Zhang
    Department of Bioengineering, The Pennsylvania State University, University Park, PA 16802, USA
    J Immunol 186:242-54. 2011
    ....
  4. ncbi Cell adhesion to fibrillin-1 molecules and microfibrils is mediated by alpha 5 beta 1 and alpha v beta 3 integrins
    Daniel V Bax
    United Kingdom Centre for Tissue Engineering, School of Biological Sciences, University of Manchester, United Kingdom
    J Biol Chem 278:34605-16. 2003
    ....
  5. pmc Platelet glycoprotein IIb/IIIa polymorphism HPA-3 b/b is associated with increased risk of ischemic stroke in patients under 60 years of age
    Hao Duan
    Department of Neurology, Shanghai 6th People s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China
    Med Sci Monit 18:CR19-24. 2012
    ..Platelet glycoprotein IIb/IIIa (GpIIb-IIIa) has been implicated in the pathogenesis of ischemic stroke. We sought to evaluate the relationship between the GpIIb/IIIa complex gene polymorphism and ischemic stroke...
  6. pmc Plasminogen activator inhibitor-1 regulates integrin alphavbeta3 expression and autocrine transforming growth factor beta signaling
    Benjamin S Pedroja
    Department of Ophthalmology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 284:20708-17. 2009
    ..6-fold increase in collagen deposition over wild type cells. These data suggest that PAI-1-mediated regulation of alphavbeta3 integrin is critical for the control of TGFbeta signaling and the prevention of fibrotic disease...
  7. pmc The integrin antagonist cilengitide activates alphaVbeta3, disrupts VE-cadherin localization at cell junctions and enhances permeability in endothelial cells
    Gian Carlo Alghisi
    Division of Experimental Oncology, Centre Pluridisciplinaire d Oncologie CePO, Faculty of Biology and Medicine, University of Lausanne, and NCCR Molecular Oncology, ISREC, Epalinges, Switzerland
    PLoS ONE 4:e4449. 2009
    ..These effects are potentially relevant to the clinical use of cilengitide as anticancer agent...
  8. ncbi The serpin PAI-1 inhibits cell migration by blocking integrin alpha V beta 3 binding to vitronectin
    S Stefansson
    Biochemistry Department, J H Holland Laboratory, American Red Cross, Rockville, Maryland 20855, USA
    Nature 383:441-3. 1996
    ....
  9. pmc Integrin alphaVbeta3 Binds to the RGD motif of glycoprotein B of Kaposi's sarcoma-associated herpesvirus and functions as an RGD-dependent entry receptor
    H Jacques Garrigues
    Department of Pathobiology, Box 357238, University of Washington, Seattle, WA 98195, USA
    J Virol 82:1570-80. 2008
    ..Our studies demonstrate that alpha(V)beta(3) is a cellular receptor mediating both the cell adhesion and entry of KSHV into target cells through binding the virion-associated gB(RGD)...
  10. pmc Activated integrin alphavbeta3 cooperates with metalloproteinase MMP-9 in regulating migration of metastatic breast cancer cells
    Melanie Rolli
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:9482-7. 2003
    ..These molecules cooperate to enhance breast cancer cell migration toward specific matrix proteins, and this may contribute to the strongly enhanced metastatic capacity of breast cancer cells that express activated alphavbeta3...
  11. pmc Syndecan-1 regulates alphavbeta3 and alphavbeta5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor
    DeannaLee M Beauvais
    Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, Madison, WI 53706, USA
    J Exp Med 206:691-705. 2009
    ..Thus, Sdc1 is a critical regulator of these two important integrins during angiogenesis and tumorigenesis, and is inhibited by the novel SSTN peptide...
  12. pmc Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling
    David A Calderwood
    Division of Vascular Biology, Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:2272-7. 2003
    ..These data establish that short integrin beta tails interact with a large number of PTB domain-containing proteins through a structurally conserved mechanism...
  13. ncbi Activation of integrin alphaIIbbeta3 by modulation of transmembrane helix associations
    Renhao Li
    Department of Biochemistry and Biophysics, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 300:795-8. 2003
    ..These results suggest that homomeric associations involving transmembrane domains provide a driving force for integrin activation. They also suggest a structural basis for the coincidence of integrin activation and clustering...
  14. doi Pinopodes, leukemia inhibitory factor, integrin-β3, and mucin-1 expression in the peri-implantation endometrium of women with unexplained recurrent pregnancy loss
    Bufang Xu
    Reproductive Medical Center of Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    Fertil Steril 98:389-95. 2012
    ....
  15. ncbi Two different beta3 cysteine substitutions alter alphaIIb beta3 maturation and result in Glanzmann thrombasthenia
    S Milet-Marsal
    UMR 5533 CNRS, Hopital Cardiologique, Pessac, France
    Thromb Haemost 88:104-10. 2002
    ..We then showed by metabolic (35S) labeling and Endo-H glycosidase treatment that these substitutions strongly affected complex maturation within the cell...
  16. ncbi Interaction of human Thy-1 (CD 90) with the integrin alphavbeta3 (CD51/CD61): an important mechanism mediating melanoma cell adhesion to activated endothelium
    Anja Saalbach
    Saxon Academy of Science, D 04107 Leipzig, Germany
    Oncogene 24:4710-20. 2005
    The expression of the alphavbeta3 integrin (CD51/CD61) on human melanoma cells has been shown to be associated most closely with tumor progression and metastases formation in melanoma...
  17. ncbi Expression and activation of alpha v beta 3 integrins by SDF-1/CXC12 increases the aggressiveness of prostate cancer cells
    Yan Xi Sun
    Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI 48109 1078, USA
    Prostate 67:61-73. 2007
    ..Stromal cell-derived factor-1 (SDF-1 or CXCL12) and CXCR4 are key elements in the metastasis of prostate cancer cells to bone--but the mechanisms as to how it localizes to the marrow remains unclear...
  18. doi Integrin alphavbeta3-mediated transcriptional regulation of TIMP-1 in a human ovarian cancer cell line
    Dong Seok Kim
    National Research Laboratory, Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, 134 Sinchon Dong Seodaemun Gu, 120 749 Seoul, Republic of Korea
    Biochem Biophys Res Commun 377:479-83. 2008
    ..These results demonstrate that integrin alphavbeta3-mediated transcriptional regulation of MMP-9 and TIMP-1 is critical for suppressing the ovarian cancer cell invasion...
  19. doi Simultaneous genotyping of human platelet antigen-1 to 17w by polymerase chain reaction sequence-based typing
    X Xu
    Blood Center of Zhejiang Province, Zhejiang, China
    Vox Sang 97:330-7. 2009
    ..Here, we set up a polymerase chain reaction sequence-based typing method for simultaneous genotyping of HPA-1 to 17w (PCR-SBT)...
  20. pmc Alphav beta3 integrin limits the contribution of neuropilin-1 to vascular endothelial growth factor-induced angiogenesis
    Stephen D Robinson
    Adhesion and Angiogenesis Laboratory, Tumour Biology Centre, Institute of Cancer, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, United Kingdom
    J Biol Chem 284:33966-81. 2009
    ..Our data suggest that beta3 integrin may, in part, negatively regulate VEGF signaling by sequestering NRP1 and preventing it from interacting with VEGFR2...
  21. doi The ins and outs of HIV-1 Tat
    Solène Debaisieux
    CPBS, UMR 5236 CNRS, Universite de Montpellier, 1919 Route de Mende, 34923, Montpellier Cedex 05, France
    Traffic 13:355-63. 2012
    ..This review focuses on some of the recently identified molecular details underlying the unusual transcellular transport pathway used by Tat, such as the role of the single Trp in Tat for its membrane insertion and translocation...
  22. pmc Membrane binding of the N-terminal ubiquitin-like domain of kindlin-2 is crucial for its regulation of integrin activation
    H Dhanuja Perera
    Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Structure 19:1664-71. 2011
    ..These data suggest a membrane-binding function of the ubiquitin-like domain of kindlin-2, which is likely common for all kindlins to promote their localization to the plasma membrane and control integrin activation...
  23. doi Endothelial cell surface expression of protein disulfide isomerase activates β1 and β3 integrins and facilitates dengue virus infection
    Shu Wen Wan
    Institute of Basic Medical Sciences, National Cheng Kung University Medical College, Tainan, Taiwan
    J Cell Biochem 113:1681-91. 2012
    ..These findings may have implications for anti-DENV drug design...
  24. ncbi Thy-1 binds to integrin beta(3) on astrocytes and triggers formation of focal contact sites
    L Leyton
    ICBM Faculty of Medicine, University of Chile, Santiago, Chile
    Curr Biol 11:1028-38. 2001
    ..In this paper, a ligand molecule for Thy-1 was identified, and the consequences of Thy-1 binding for astrocyte function were investigated...
  25. doi Transforming growth factor beta1 induces alphavbeta3 integrin expression in human lung fibroblasts via a beta3 integrin-, c-Src-, and p38 MAPK-dependent pathway
    Dmitri V Pechkovsky
    University of British Columbia, Vancouver, British Columbia V6Z1Y6, Canada
    J Biol Chem 283:12898-908. 2008
    ..These data identify a novel mechanism for TGFbeta1 signaling in human lung fibroblasts by which they may contribute to normal and pathological wound healing...
  26. pmc Kindlin-2 regulates podocyte adhesion and fibronectin matrix deposition through interactions with phosphoinositides and integrins
    Hong Qu
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Cell Sci 124:879-91. 2011
    ..Our results reveal important functions of kindlin-2 in the regulation of podocyte-matrix adhesion and matrix deposition and shed new light on the mechanism whereby kindlin-2 functions in these processes...
  27. pmc Rationally designed integrin beta3 mutants stabilized in the high affinity conformation
    Bing Hao Luo
    Immune Disease Institute and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 284:3917-24. 2009
    ..This detailed understanding of the conformational change will assist in the development of allosteric drugs that either stabilize or destabilize specific integrin conformations without occluding the ligand-binding site...
  28. ncbi Thrombspondin acts via integrin-associated protein to activate the platelet integrin alphaIIbbeta3
    J Chung
    Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 272:14740-6. 1997
    ..Thus an important function of TS1 in platelets is that of a secreted costimulator of alphaIIbbeta3 whose unique properties result in its localization to the platelet surface and the fibrin clot...
  29. ncbi The platelet Pl(A2) and angiotensin-converting enzyme (ACE) D allele polymorphisms and the risk of recurrent events after acute myocardial infarction
    P F Bray
    Department of Medicine, Thrombosis Research Section, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Cardiol 88:347-52. 2001
    ..These data suggest that it would be important to perform a larger study to address the potential role of these genotypes in therapeutic decision making...
  30. ncbi Potential thrombophilic mutations/polymorphisms in patients with no flow-limiting stenosis after myocardial infarction
    John K French
    Department of Molecular Medicine, University of Auckland, Auckland, New Zealand
    Am Heart J 145:118-24. 2003
    ..Although inherited thrombophilias are more common in patients with venous thromboembolism, their influence on the development of myocardial infarction (MI) requires clarification...
  31. ncbi PLA1/A2 polymorphism of the platelet glycoprotein receptor IIb/IIIa in young patients with cryptogenic TIA or ischemic stroke
    Mary Lou P J van Goor
    Department of Neurology of the Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Thromb Res 108:63-5. 2002
    ..The purpose of this study was to investigate a possible association between the GPIIb/IIIa PIA1/A2 polymorphism and the occurrence of cryptogenic stroke in young patients...
  32. ncbi Increased prevalence of platelet glycoprotein IIb/IIIa PLA2 allele in ischaemic stroke associated with large vessel pathology
    Zoltan Szolnoki
    Department of Neurology and Neurophysiology, Gyula, Hungary
    Thromb Res 109:265-9. 2003
    ..There are indications that the A2 allele can also be associated with acute thrombosis or stroke. The purpose of this study was to study the distribution of the A2 allele in different vascular subtypes of stroke disease...
  33. ncbi Integrin beta3 Leu33Pro homozygosity and risk of cancer
    Stig E Bojesen
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark
    J Natl Cancer Inst 95:1150-7. 2003
    ..The Leu33Pro polymorphism of the beta3 subunit modulates the function of alpha(IIb)beta3 integrin. We examined whether this polymorphism influences cancer risk...
  34. ncbi Platelet GP IIIa polymorphism HPA-1 (PlA) protects against subarachnoid hemorrhage
    Juan A Iniesta
    Hematology and Oncology Service, Centro Regional de Hemodonacion, Universidad de Murcia, Spain
    Stroke 35:2282-6. 2004
    ..Few genetic modifications have been identified to be associated with subarachnoid hemorrhage (SAH), most of them playing a role in the formation or size of aneurysms...
  35. ncbi Expression of alpha 1 and beta 3 integrins subunits in the endometrium of patients with tubal phimosis or hydrosalpinx
    Ricardo Francalacci Savaris
    Ambulatório de Fertilidade, Grupo Hospitalar Conceição, Ministerio da Saude, Porto Alegre, RS, Brazil
    Fertil Steril 85:188-92. 2006
    ..To determine the expression of alpha1 and beta3 integrin subunit on the endometrium of infertile patients with hydrosalpinx and infertile patients with tubal phimosis...
  36. ncbi Mutation of a conserved asparagine in the I-like domain promotes constitutively active integrins alphaLbeta2 and alphaIIbbeta3
    Ming Cheng
    School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551
    J Biol Chem 282:18225-32. 2007
    ....
  37. ncbi Association of human platelet alloantigen 1 through 5 polymorphisms with ischemic stroke
    Sarra Saidi
    Research Unit of Hematological and Autoimmune Diseases, Faculty of Pharmacy, University of Monastir, Monastir, Tunisia
    Cerebrovasc Dis 25:81-6. 2008
    Polymorphisms in human platelet alloantigen (HPA)-1 and HPA-3 (GPIIb/IIIa), HPA-2 (GPIb/IX), HPA-4 (GPIIIa) and HPA-5 (GPIa/IIa) were investigated in 216 stroke patients and 318 matched control subjects...
  38. doi Interaction and functional association of protein disulfide isomerase with alphaVbeta3 integrin on endothelial cells
    Maria Swiatkowska
    Department of Molecular and Medical Biophysics, Medical University in Lodz, 6 8 Mazowiecka Street, Lodz, Poland
    FEBS J 275:1813-23. 2008
    ..Thus, we show that Mn(2+) simultaneously modulates the thiol isomerase activity of PDI that is bound to alpha(V)beta(3) and induces its transition to the ligand-competent state, suggesting an alternative mechanism of integrin regulation...
  39. doi A1/A2 polymorphism of GpIIIa gene and a risk of aneurysmal subarachnoid haemorrhage
    Mateusz G Adamski
    Department of Neurology, Jagiellonian University Medical College, Krakow, Poland
    Biochem Biophys Res Commun 383:228-30. 2009
    ..The aim of this study was to investigate the association between the GpIIIa gene A1/A2 polymorphism and a risk of aneurysmal subarachnoid haemorrhage (SAH) in a Polish population...
  40. doi Impact of COX-2 rs5275 and rs20417 and GPIIIa rs5918 polymorphisms on 90-day ischemic stroke functional outcome: a novel finding
    Jane Maguire
    School of Medicine and Public Health, Faculty of Health, University of Newcastle, Callaghan, New South Wales, Australia
    J Stroke Cerebrovasc Dis 20:134-44. 2011
    ..and genotyped for polymorphisms in platelet glycoprotein Ibα (GPIbα) rs224309 and rs6065, glycoprotein IIIa (GPIIIa) rs5918, tissue plasminogen activator (tPA) rs63020761, plasminogen activating inhibitor (PAI-1) rs72578597, and ..
  41. pmc Dissociation of bimolecular αIIbβ3-fibrinogen complex under a constant tensile force
    Rustem I Litvinov
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Biophys J 100:165-73. 2011
    ..Taken together, these data provide important quantitative and qualitative characteristics of αIIbβ3-fibrinogen binding and unbinding that underlie the dynamics of platelet adhesion and aggregation in blood flow...
  42. ncbi A novel fibronectin receptor with an unexpected subunit composition (alpha v beta 1)
    B E Vogel
    Cancer Research Center, La Jolla Cancer Research Foundation, California 92037
    J Biol Chem 265:5934-7. 1990
    ..Its unexpected subunit composition demonstrates the importance of the beta subunit in determining the ligand specificity of integrins and suggests that the current integrin classification scheme needs revision...
  43. ncbi Glanzmann's thrombasthenia: identification of 19 new mutations in 30 patients
    Giovanna D'Andrea
    Unita di Aterosclerosi e Trombosi, I R C C S Casa Sollievo della Sofferenza, S Giovanni Rotondo, Italy
    Thromb Haemost 87:1034-42. 2002
    ..In conclusion, we have identified a spectrum of unreported mutations that may be of value to unravel the role of specific regions of alphaIIb and beta3 genes...
  44. ncbi Mechanosensitive induction of apoptosis in fibroblasts is regulated by thrombospondin-1 and integrin associated protein (CD47)
    R Graf
    Institute of Biochemistry, Technical University of Darmstadt, Petersenstrasse 22, D 64287 Darmstadt, Germany
    Apoptosis 7:493-8. 2002
    ..The presented mechanosensitive regulation of apoptosis in fibroblast cultures could be an essential mechanism for the regression of the granulation tissue by apoptosis in the process of wound healing...
  45. ncbi Integrin alphavbeta3 binding to human alpha5-laminins facilitates FGF-2- and VEGF-induced proliferation of human ECV304 carcinoma cells
    Elke Genersch
    Department of Cell and Molecular Biology, Lund University, Lund Sweden
    Eur J Cell Biol 82:105-17. 2003
    ..Our data suggest that this interaction is involved in the regulation of cellular responses to growth factors known to be involved in epithelial and endothelial development...
  46. ncbi Plasminogen activator inhibitor type 1 (PAI1) and platelet glycoprotein IIIa (PGIIIa) polymorphisms in Black South Africans with pre-eclampsia
    Rosemary J Pegoraro
    Department of Chemical Pathology, Nelson R Mandela School of Medicine, University of Natal, Durban, South Africa
    Acta Obstet Gynecol Scand 82:313-7. 2003
    ..Association of fibrin abnormalities with pre-eclampsia prompted this study to examine whether polymorphisms in the plasminogen activator inhibitor Type 1 and platelet glycoprotein IIIa genes constitute risk factors for this condition...
  47. pmc Critical cysteine residues for regulation of integrin alphaIIbbeta3 are clustered in the epidermal growth factor domains of the beta3 subunit
    Tetsuji Kamata
    Department of Cell Biology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Biochem J 378:1079-82. 2004
    ..It has also been proposed that unique cysteine residues in the integrin beta3 subunit are involved in the regulation of alphaIIbbeta3...
  48. pmc Three-dimensional EM structure of the ectodomain of integrin {alpha}V{beta}3 in a complex with fibronectin
    Brian D Adair
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Cell Biol 168:1109-18. 2005
    ..We conclude that the ectodomain of alphaVbeta3 manifests a bent conformation that is capable of stably binding a physiological ligand in solution...
  49. ncbi Integrin alphavbeta3 as a target for blocking HIV-1 Tat-induced endothelial cell activation in vitro and angiogenesis in vivo
    Chiara Urbinati
    Department of Biomedical Sciences and Biotechnology, University of Brescia, Italy
    Arterioscler Thromb Vasc Biol 25:2315-20. 2005
    ..Here, we investigated the biological consequences of Tat/alphavbeta3 interaction and the antagonist effect of an Arg-Gly-Asp (RGD)-based peptidomimetic...
  50. ncbi alphaVbeta6 is a novel receptor for human fibrillin-1. Comparative studies of molecular determinants underlying integrin-rgd affinity and specificity
    Jelena Jovanovic
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom
    J Biol Chem 282:6743-51. 2007
    ..Non-focal contact distribution of alpha5beta1 suggests that its engagement by fibrillin-1 may elicit a lesser degree and/or different type of intracellular signaling compared with that seen with a high affinity ligand...
  51. ncbi Immunologic and structural analysis of eight novel domain-deletion beta3 integrin peptides designed for detection of HPA-1 antibodies
    P Stafford
    Department of Haematology, University of Cambridge, Cambridge, UK
    J Thromb Haemost 6:366-75. 2008
    ..HPA-1 antibodies are clinically the most relevant in the Caucasoid population, but detection currently requires alpha(IIb)beta3 integrin from the platelets of HPA-genotyped donors...
  52. doi Rho GTPases mediated integrin alpha v beta 3 activation in sphingosine-1-phosphate stimulated chemotaxis of endothelial cells
    Lichun Wang
    Gheens Center on Aging, Department of Microbiology and Immunology, University of Louisville Health Sciences Center, Louisville, KY 40202, USA
    Histochem Cell Biol 129:579-88. 2008
    ..Collectively, these data indicate that the S1P-mediated signaling via the S1P1/Gi/Rho GTPases pathway activates integrin alpha v beta 3, which is indispensable for S1P-stimulated chemotactic response of ECs...
  53. pmc Kindlin-2 (Mig-2): a co-activator of beta3 integrins
    Yan Qing Ma
    Department of Molecular Cardiology, Cleveland Clinic, Cleveland, OH 44195, USA
    J Cell Biol 181:439-46. 2008
    ..Our results thus identify kindlin-2 as a novel regulator of integrin activation; it functions as a coactivator...
  54. pmc Sphingosine kinase-1 associates with integrin {alpha}V{beta}3 to mediate endothelial cell survival
    Jennifer R Gamble
    Centenary Institute for Cancer Medicine and Cell Biology, University of Sydney, Australia
    Am J Pathol 175:2217-25. 2009
    ....
  55. doi Human platelet antigen polymorphisms (HPA-1, -2, -3, -4, -5 and -15) in major ethnic groups of Pakistan
    F A Bhatti
    PNS Shifa Hospital, Karachi, Pakistan
    Transfus Med 20:78-87. 2010
    ....
  56. pmc Interaction of alphaVbeta3 and alphaVbeta6 integrins with human parechovirus 1
    Jani Seitsonen
    Department of Biosciences, Institute of Biotechnology, PO Box 65, Viikinkaari 1, FIN 00014 University of Helsinki, Finland
    J Virol 84:8509-19. 2010
    ..This first structural characterization of a parechovirus indicates that the differences in receptor binding are due to the amino acid differences in the integrins rather than to significantly different viral footprints...
  57. pmc HIV-1 Tat-induced platelet activation and release of CD154 contribute to HIV-1-associated autoimmune thrombocytopenia
    J Wang
    Department of Medicine, NYU Cancer Institute, New York, NY 10016, USA
    J Thromb Haemost 9:562-73. 2011
    ..The mechanism by which HIV-1 infection leads to platelet activation and the effect of this activation on the development of HIV-1 ITP, however, is not fully understood...
  58. doi Analysis of plasminogen activator inhibitor-1, integrin beta3, beta fibrinogen, and methylenetetrahydrofolate reductase polymorphisms in Iranian women with recurrent pregnancy loss
    Mahmood Jeddi-Tehrani
    Monoclonal Antibody Research Center, Avicenna Research Institute, ACECR, Shahid Beheshti University, Evin, Tehran, Iran
    Am J Reprod Immunol 66:149-56. 2011
    ..the associations of the plasminogen activator inhibitor-1 (PAI-1) -675 4G/5G, beta fibrinogen (BF) -455G/A, integrin beta 3 (ITGB3) 1565T/C, and methylenetetrahydrofolate reductase (MTHFR) 677C/T and 1298A/C polymorphisms with ..
  59. doi Vicinal thiols are required for activation of the αIIbβ3 platelet integrin
    N Manickam
    Division of Hematology, Department of Medicine, The University of Texas Health Science Center, San Antonio, TX, USA
    J Thromb Haemost 9:1207-15. 2011
    ..These thiols provide a mechanism to regulate protein function. We previously found that thiols in both αIIb and β3 of the αIIbβ3 fibrinogen receptor were required for platelet aggregation...
  60. pmc Intact alphaIIbbeta3 integrin is extended after activation as measured by solution X-ray scattering and electron microscopy
    Edward T Eng
    Immune Disease Institute, Children s Hospital Boston, and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 286:35218-26. 2011
    ..The observed extension and conformational rearrangement upon activation are consistent with the extension and headpiece opening model of integrin activation...
  61. doi Mean platelet volume and integrin alleles correlate with levels of integrins α(IIb)β(3) and α(2)β(1) in acute coronary syndrome patients and normal subjects
    Thomas J Kunicki
    CHOC Children s Hospital, Hematology Research, 455 South Main Street, Orange, CA 92868, USA
    Arterioscler Thromb Vasc Biol 32:147-52. 2012
    ..Our objective was to parse the contribution of mean platelet volume (MPV) and integrin gene alleles to this variation in large cohorts of patients with acute coronary syndrome (ACS) and normal subjects...
  62. pmc Unique disulfide bonds in epidermal growth factor (EGF) domains of β3 affect structure and function of αIIbβ3 and αvβ3 integrins in different manner
    Ronit Mor-Cohen
    The Amalia Biron Research Institute of Thrombosis and Hemostasis, Chaim Sheba Medical Center, Tel Hashomer, Israel
    J Biol Chem 287:8879-91. 2012
    ....
  63. ncbi Thymidine phosphorylase and 2-deoxyribose stimulate human endothelial cell migration by specific activation of the integrins alpha 5 beta 1 and alpha V beta 3
    Kylie A Hotchkiss
    Department of Oncology, Albert Einstein College of Medicine, Bronx, New York 10467, USA
    J Biol Chem 278:19272-9. 2003
    ..These experiments are the first to demonstrate a direct effect of thymidine phosphorylase and 2-deoxyribose on signaling pathways associated with endothelial cell migration...
  64. pmc Reduced expression of alphavbeta3 integrin in the endometrium of unexplained infertility patients with recurrent IVF-ET failures: improvement by danazol treatment
    Chisei Tei
    Department of Obstetrics and Gynecology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku, Tokyo 160 8582, Japan
    J Assist Reprod Genet 20:13-20. 2003
    ..To determine whether there is any association between the expression of endometrial integrin alphavbeta3 and repeated IVF-ET failure and to examine the effect of danazol treatment on alphavbeta3 expression...
  65. ncbi Association of extracellular matrix proteins fibulin-1 and fibulin-2 with fibronectin in bone marrow stroma
    Y C Gu
    Department of Cell and Molecular Biology, Lund University, Lund, Sweden
    Br J Haematol 109:305-13. 2000
    ..in BM stroma is related to binding to the major cell adhesion protein fibronectin, whereas adhesion of mouse fibulin-2 to human cells containing the integrin beta3 chain is not related to an apparent physiological function of the protein.
  66. ncbi Signaling pathways of the F11 receptor (F11R; a.k.a. JAM-1, JAM-A) in human platelets: F11R dimerization, phosphorylation and complex formation with the integrin GPIIIa
    Malgorzata B Sobocka
    Department of Anatomy and Cell Biology, SUNY Downstate Medical Center, Brooklyn, New York 11203, USA
    J Recept Signal Transduct Res 24:85-105. 2004
    ..F11R dimerization coincident with a decrease in monomeric F11R, and association of the F11R with the integrin GPIIIa and with CD9...
  67. ncbi Modulation of ADP-induced platelet activation by aspirin and pravastatin: role of lectin-like oxidized low-density lipoprotein receptor-1, nitric oxide, oxidative stress, and inside-out integrin signaling
    Muhammad R Marwali
    Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, AR 72205 7199, USA
    J Pharmacol Exp Ther 322:1324-32. 2007
    ..Furthermore, aspirin and pravastatin inhibit LOX-1 expression on platelets in part by favorably affecting ROS and NO release from activated platelets...
  68. doi Stromal cell-derived factor-1 increase alphavbeta3 integrin expression and invasion in human chondrosarcoma cells
    Tzu Hsiu Lai
    Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan
    J Cell Physiol 218:334-42. 2009
    ..Taken together, our results indicate that lung derived-SDF-1alpha enhances the invasiveness of chondrosarcoma cells by increasing alphavbeta3 integrin expression through the CXCR4/ERK/NF-kappaB signal transduction pathway...
  69. pmc Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling
    Brian P Eliceiri
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Cell Biol 157:149-60. 2002
    ..Supporting these results, mice deficient in either pp60c-src or integrin beta5, but not integrin beta3, have a reduced VP response to VEGF...
  70. ncbi Signaling through JAM-1 and alphavbeta3 is required for the angiogenic action of bFGF: dissociation of the JAM-1 and alphavbeta3 complex
    Meghna U Naik
    Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
    Blood 102:2108-14. 2003
    ..In addition, blockage of either JAM-1 or alphavbeta3 inhibits bFGF-induced MAP kinase activation. Thus, our results suggest that signaling through JAM-1 and alphavbeta3 is necessary for bFGF-induced angiogenesis...
  71. ncbi Locking the beta3 integrin I-like domain into high and low affinity conformations with disulfides
    Bing Hao Luo
    CBR Institute fo Biomedical Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 279:10215-21. 2004
    ..e. that axial movement in the C-terminal direction of the alpha7-helix is linked to rearrangement of the I-like domain metal ion-dependent adhesion site into a high affinity conformation...
  72. pmc Mechanisms of integrin-vascular endothelial growth factor receptor cross-activation in angiogenesis
    Ganapati H Mahabeleshwar
    Department of Molecular Cardiology, The Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Circ Res 101:570-80. 2007
    ....
  73. doi Polymorphisms in predicted microRNA-binding sites in integrin genes and breast cancer: ITGB4 as prognostic marker
    Annika Brendle
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Carcinogenesis 29:1394-9. 2008
    ..None of the SNPs was significantly associated with BC risk. As the ITGB4 SNP seems to influence tumour aggressiveness and survival, it may have prognostic value in the clinic...
  74. pmc Ser-752-->Pro mutation in the cytoplasmic domain of integrin beta 3 subunit and defective activation of platelet integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) in a variant of Glanzmann thrombasthenia
    Y P Chen
    Unité 348 de l Institut National de la Santé et de la Recherche Médicale, Hopital Lariboisiere, Paris, France
    Proc Natl Acad Sci U S A 89:10169-73. 1992
    ..Our data thus identify the C-terminal portion of the cytoplasmic domain of beta 3 as an intrinsic element in the coupling between alpha IIb beta 3 and platelet activation...
  75. ncbi HIV-1-Tat protein promotes chemotaxis and invasive behavior by monocytes
    R M Lafrenie
    Laboratories of Developmental Biology and Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, MD, USA
    J Immunol 157:974-7. 1996
    ....
  76. pmc Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2
    R Soldi
    Institute for Cancer Research and Treatment IRCC, Biology and Biochemistry, School of Medicine, University of Torino, 10100 Torino, Italy
    EMBO J 18:882-92. 1999
    ....
  77. ncbi Immunohistochemical analysis of beta3 integrin (CD61): expression in pig tissues and human tumors
    A Merono
    Department of Genetic, Spanish Research Council University of Córdoba, Spain
    Histol Histopathol 17:347-52. 2002
    ..We have used a monoclonal antibody against the porcine gpIIIa or CD61 (JM2E5) to study the distribution of this molecule in different normal pig tissues...
  78. ncbi Agonist-specific structural rearrangements of integrin alpha IIbbeta 3. Confirmation of the bent conformation in platelets at rest and after activation
    Maria J Calzada
    Departamento de Biofisica Molecular, Instituto de Quimica Fisica, Consejo Superior de Investigaciones Cientificas, Serrano 119, E 28006 Madrid, Spain
    J Biol Chem 277:39899-908. 2002
    ....
  79. ncbi Structural determinants of integrin recognition by talin
    Begoña García-Alvarez
    Program on Cell Adhesion, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Mol Cell 11:49-58. 2003
    ..In combination with NMR and mutational analysis, our studies reveal the critical interacting elements of both talin and the integrin beta 3 tail, providing structural paradigms for integrin linkage to the cell interior.
  80. ncbi Platelet glycoprotein IIb/IIIa Pl(A2)/Pl(A2) homozygosity associated with risk of ischemic cardiovascular disease and myocardial infarction in young men: the Copenhagen City Heart Study
    Stig E Bojesen
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark
    J Am Coll Cardiol 42:661-7. 2003
    ....
  81. ncbi Cholesterol-independent interactions with CD47 enhance alphavbeta3 avidity
    John F McDonald
    Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 279:17301-11. 2004
    ....
  82. ncbi Contribution of PAR-1, PAR-4 and GPIbalpha in intracellular signaling leading to the cleavage of the beta3 cytoplasmic domain during thrombin-induced platelet aggregation
    Christophe Dubois
    Sylvie Meyer Reigner, PRBD M, 68 217b, Hoffmann La Roche, 4070 Basel, Switzerland
    Thromb Haemost 91:733-42. 2004
    ....
  83. ncbi Variation in ITGB3 has sex-specific associations with plasma lipoprotein(a) and whole blood serotonin levels in a population-based sample
    Lauren A Weiss
    Department of Human Genetics, The University of Chicago, IL 60637, USA
    Hum Genet 117:81-7. 2005
    ..Our results suggest that variation in ITGB3 in addition to Leu33Pro could contribute to susceptibility to CVD and serotonin in a sex-specific manner...
  84. ncbi alpha(v)beta3-integrin-dependent activation of focal adhesion kinase mediates NF-kappaB activation and motogenic activity by HIV-1 Tat in endothelial cells
    Chiara Urbinati
    General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, Viale Europe 11, 25123 Brescia, Italy
    J Cell Sci 118:3949-58. 2005
    ..Since Tat accumulates in an immobilized form in the extracellular matrix, these results provide new biochemical and biological insights about alpha(v)beta3/Tat interaction exploitable for the design of anti-Tat strategies...
  85. ncbi Regulation of integrin alphaIIbbeta3 activation by distinct regions of its cytoplasmic tails
    Yan Qing Ma
    Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Biochemistry 45:6656-62. 2006
    ..Together, these data provide molecular insights into how distinct regions of the cytoplasmic tails differentially and cooperatively regulate integrin activation...
  86. ncbi The specificity and function of the metal-binding sites in the integrin beta3 A-domain
    Michelle M Pesho
    Joseph J Jacobs Center for Thrombosis and Vascular Biology and Department of Molecular Cardiology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Biol Chem 281:23034-41. 2006
    ..These results indicate that the specificities of the three metal-binding sites for divalent cations are distinct and that each site can regulate the ligand binding potential of the beta3 A-domain...
  87. ncbi Platelet integrin alpha(IIb)beta(3): activation mechanisms
    Y Q Ma
    Department of Molecular Cardiology, Joseph J Jacobs Center for Thrombosis and Vascular Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA
    J Thromb Haemost 5:1345-52. 2007
    ..Among them, talin appears to be a critical trigger of alpha(IIb)beta(3) activation, but other binding partners, which function as activators or suppressors, are likely to act as co-regulators of integrin activation...
  88. ncbi Gene frequencies of the HPA-1 platelet antigen alleles in the Lebanese population
    A S Sabbagh
    Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Beirut, Lebanon
    Transfus Med 17:473-8. 2007
    ..This report is the first to study the prevalence of the HPA-1 system in the Lebanese population and serves as a template for future clinical research involving platelet disorders and cardiovascular diseases...
  89. ncbi Quantitative gene-expression of the tumor angiogenesis markers vascular endothelial growth factor, integrin alphaV and integrin beta3 in human neuroendocrine tumors
    Jytte Oxboel
    Cluster for Molecular Imaging, Department of Biomedical Sciences, University of Copenhagen, DK 2200 Copenhagen N, Denmark
    Oncol Rep 21:769-75. 2009
    ..PCR for measuring mRNA gene-expression of vascular endothelial growth factor (VEGF), integrin alphaV, and integrin beta3, and CD34 for a group of patients with neuroendocrine tumors (n=13)...
  90. pmc Assignment of disulphide bonds in human platelet GPIIIa. A disulphide pattern for the beta-subunits of the integrin family
    J J Calvete
    Instituto de Quimica Fisica, C S I C, Madrid, Spain
    Biochem J 274:63-71. 1991
    ..Glycoprotein IIIa (GPIIIa or beta 3 subunit) is the common beta-subunit of the beta 3 subfamily of integrins, which, when associated with ..
  91. ncbi The genomic organization of platelet glycoprotein IIIa
    A B Zimrin
    Hematology Oncology Section, Hospital of the University of Pennsylvania, Philadelphia
    J Biol Chem 265:8590-5. 1990
    ..In this report, we describe the isolation of genomic DNA coding for the entire mature GPIIIa protein...
  92. ncbi Calpain cleavage of the cytoplasmic domain of the integrin beta 3 subunit
    X Du
    Department of Vascular Biology, Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 270:26146-51. 1995
    ..We report that the cytoplasmic domain of the integrin beta 3 subunit undergoes limited proteolysis by calpain, an intracellular calcium-dependent protease...
  93. pmc The Tat protein of human immunodeficiency virus type 1, a growth factor for AIDS Kaposi sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence
    G Barillari
    Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 90:7941-5. 1993
    ..The results also suggest that RGD-recognizing integrins mediate the vascular cell-growth-promoting effect of Tat...
  94. ncbi Monocyte-derived dendritic cells and monocytes migrate to HIV-Tat RGD and basic peptides
    R Benelli
    Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
    AIDS 12:261-8. 1998
    ..In vivo, Tat stimulates invasion of macrophages into a matrigel sponge...
  95. ncbi A Ser162-->Leu mutation within glycoprotein (GP) IIIa (integrin beta3) results in an unstable alphaIIbbeta3 complex that retains partial function in a novel form of type II Glanzmann thrombasthenia
    D E Jackson
    Blood Research Institute, The Blood Center of Southeastern Wisconsin, Milwaukee 53233 2194, USA
    Thromb Haemost 80:42-8. 1998
    ..Taken together, these data implicate the region encompassing Ser162 in the stabilization and ligand binding properties of the alphaIIbbeta3 complex...
  96. ncbi The Tat protein of human immunodeficiency virus type-1 promotes vascular cell growth and locomotion by engaging the alpha5beta1 and alphavbeta3 integrins and by mobilizing sequestered basic fibroblast growth factor
    G Barillari
    Laboratory of Virology, Istituto Superiore di Sanita, Rome, Italy
    Blood 94:663-72. 1999
    ..This soluble bFGF mediates Tat-induced vascular cell growth. These effects resemble those of extracellular matrix proteins, suggesting that Tat enhances angiogenesis and promotes KS progression by a molecular mimicry of these molecules...
  97. ncbi Inflammatory cytokines synergize with the HIV-1 Tat protein to promote angiogenesis and Kaposi's sarcoma via induction of basic fibroblast growth factor and the alpha v beta 3 integrin
    G Barillari
    Laboratory of Virology, Istituto Superiore di Sanita, Rome, Italy
    J Immunol 163:1929-35. 1999
    ....
  98. ncbi Identification of a talin-binding site in the integrin beta(3) subunit distinct from the NPLY regulatory motif of post-ligand binding functions. The talin n-terminal head domain interacts with the membrane-proximal region of the beta(3) cytoplasmic tail
    S Patil
    Department of Pharmacology, The University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 274:28575-83. 1999
    ..Moreover, talin was shown to bind through its N-terminal head domain to the membrane-proximal sequence of the beta(3) cytoplasmic tail...
  99. ncbi Platelet-derived growth factor receptor beta and vascular endothelial growth factor receptor 2 bind to the beta 3 integrin through its extracellular domain
    E Borges
    Cancer Research Center, The Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 275:39867-73. 2000
    ..These results show that the interactions that lead to the association of the alpha(v)beta(3) integrin with PDGF-Rbeta and VEGF-R2 and enhancement of RTK activity take place outside the cell...
  100. ncbi Glycoprotein IIIa Pl(A1/A2) polymorphism and sudden cardiac death
    J Mikkelsson
    Medical School, University of Tampere and Tampere University Hospital, Finland
    J Am Coll Cardiol 36:1317-23. 2000
    ..We studied the association of the Pl(A1/A2) polymorphism with coronary thrombosis, myocardial infarction (MI) and sudden cardiac death (SCD) in autopsied victims of sudden death...
  101. pmc Crystal structure of the extracellular segment of integrin alpha Vbeta3
    J P Xiong
    Renal Unit, Leukocyte Biology and Inflammation Program, Structural Biology Program, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Science 294:339-45. 2001
    ..MIDAS lies adjacent to a calcium-binding site with a potential regulatory function...

Research Grants60

  1. BIOSYNTHESIS NAD STRUCTURE OF THE FIBRINOGEN RECEPTOR
    Paul Bray; Fiscal Year: 1990
    ..Platelet membrane glycoproteins IIb (GPIIb) and IIIa (GPIIIa) exist as a heterodimeric complex in the platelet membrane and function as the receptor for fibrinogen...
  2. CELLULAR CONSEQUENCES OF DEFECTIVE IIB AND IIIA GENES
    Paul Bray; Fiscal Year: 1993
    ..sequences controlling the normal expression of the genes for platelet membrane glycoproteins IIb (GPIIb) and IIIa (GPIIIa), and (2) to analyze the cellular consequences of these defects...
  3. GLYCOPROTEINS IIB AND IIIA IN PLATELETS AND NEUTROPHILS
    Lisa Jennings; Fiscal Year: 1991
    Human platelet glycoproteins IIb and IIIa (GPIIb and GPIIIa) are proteins on the membrane surface which mediate the aggregation of platelets in response to vascular injury...
  4. THE IMMUNOGENICITY OF HUMAN PLATELET PROTEINS
    Thomas Kunicki; Fiscal Year: 1990
    ..reported here, additional alloantigens are also associated with platelet glycoproteins: Pen is localized to GPIIIa, and P1E is localized to GPIb, the receptor for von Willebrand factor that mediates platelet adhesion to the ..
  5. BIOSYNTHESIS AND GENETICS OF GLYCOPROTEINS IIB AND IIIA
    Marc Shuman; Fiscal Year: 1993
    ..Site-directed mutagenesis and deletional mutants of GPIIb and GPIIIa cDNA will be used to transcribe mutant mRNAs using a SP6 promoter...
  6. STRUCTURAL STUDIES OF PLATELET GPIIB/IIIA ACTIVATION
    JOEL BENNETT; Fiscal Year: 1999
    ..in vitro mutagenesis to examine the structural features of the cytoplasmic and transmembrane domains of GPIIb and GPIIIa that contribute to GPIIb-IIIa activation...
  7. INTERACTION OF CELLS WITH POLYMERIZING FIBRIN
    Stefan Niewiarowski; Fiscal Year: 1992
    ..This suggests that fibrinogen binding sites are located in the NH2-terminal portion of the GPIIIa molecule...
  8. PEPTIDE INHIBITORS OF PLATELET AGGREGATION
    Israel Charo; Fiscal Year: 1990
    ..plate assay for the binding of fibrinogen to GPIIb-IIIa, and will identify the fibroingen-binding domains on GPIIIa will be tested for their ability to inhibit fribrinogen binding to GPIIb-IIIa...
  9. Genetic Modifiers in Children with Sickle Cell Anemia
    Russell Ware; Fiscal Year: 2005
    ..abstract_text> ..
  10. HIV Associated Thrombocytopenia
    Zongdong Li; Fiscal Year: 2009
    ..ITP is strongly associated with a high affinity IgG1 polyclonal antibody against the platelet integrin subunit GPIIIa 49-66...
  11. MODELING OF PLATELET ALLOANTIGENS
    Emily Barron Casella; Fiscal Year: 2002
    ..In both disorders, anti-HPA-1a antibodies are made against HPA-1a GPIIIa, leading to thrombocytopenia...
  12. MICROVASCULAR FAILURE IN MURINE AND PRIMATE STROKE
    E Connolly; Fiscal Year: 2000
    ..Guided by the results of aim #1 and aim #2 the PI plans to use either an anti-platelet strategy (GPIIb/GPIIIa antagonist) or an anti-adhesion receptor strategy (humanized anti P and E-selectin antibody) to demonstrate ..
  13. MOLECULAR BIOLOGY OF CYTOADHESINS--ORAL TISSUE MODEL
    GILBERT WHITE; Fiscal Year: 1990
    ..During cell activation, GPIIb and GPIIIa as one cell bind fibrinogen and contact GPIIb and GPIIIa on another cell to form an adherent complex...
  14. ANTIBODIES IN PATHOGENESIS OF HIV-1 TROMBOCYTOPENIA
    Henrik Ditzel; Fiscal Year: 2003
    ..He plans to: 1) Test these Ab's in 2 mouse models: a Balb/c mouse known to react with human anti-GPIIIa Ab by developing thrombocytopenia, and a SCID mouse engrafted with human platelets where the human Ag's share no ..
  15. MECHANISM OF ACTIVATION OF PLATELET GPIIB AND GPIIIA
    Jeffrey Smith; Fiscal Year: 2001
    ..Binding studies will be performed between Ca2+ and purified conformers of dormant and active IIb-IIIa. Results from this analysis should determine which class of ion binding sites regulate activation of the integrin. ..
  16. Defining the Role of TREM-Like Transcript-1 in Platelet Aggregation
    A Washington; Fiscal Year: 2009
    ..Clot retraction in platelets is mediated by the CD41/CD61 interaction with its ligand fibrin(ogen)...
  17. Defining the Role of TREM-Like Transcript-1 in Platelet Aggregation
    A Washington; Fiscal Year: 2007
    ..Clot retraction in platelets is mediated by the CD41/CD61 interaction with its ligand fibrin(ogen)...
  18. ASISH KUMAR GHOSH; Fiscal Year: 2016
    ..plasma contained elevated levels of MV;and (b) a phenotypic shift from predominantly "platelet-derived" (PD) MV (CD61+) in early stages of CLL toward a more "leukemic B-cell derived" (LD) MV (CD19+) during advanced stages...
  19. Unraveling the Genetic Etiology of Autism
    James S Sutcliffe; Fiscal Year: 2010
    ..abstract_text> ..
  20. MEGAKARYOCYTE EXPANSION FROM MOBILIZED PERIPHERAL BLOOD
    Alan Smith; Fiscal Year: 1999
    ..MK output will be assessed by cell morphology, flow cytometry (CD34, CD61, CD41, ploidy), and colony assay...
  21. MOLECULAR BIOLOGY OF COLLAGEN RECEPTORS
    Thomas Kunicki; Fiscal Year: 2004
    ..The successful completion of the proposed studies will lead to a substantial increase in our understanding of the genetics and physiology of the platelet collagen receptor, GPVI. ..
  22. Molecular Genetics of Integrin Collagen Receptors
    Thomas Kunicki; Fiscal Year: 2007
    ..From a clinical standpoint, these studies will also reveal the impact of these gene differences on risk for adverse events in bleeding disorders such as Von Willebrand Disease. ..
  23. INTERACTION OF OSTEOPONTIN WITH ADHESION RECEPTORS
    JOEL BENNETT; Fiscal Year: 2002
    ..Our results suggest that it may be possible to inhibit the formation of platelet thrombi in arteries involved by atherosclerosis by preventing the interaction of platelet alphavbeta3 with osteopontin. ..
  24. Rare Antigens in Neonatal Alloimmune Thrombocytopenia
    Julie Peterson; Fiscal Year: 2006
    ..4. Generate soluble recombinant platelet glycoproteins carrying "rare" platelet alloantigens to provide a tool for rapid detection and identification of antibodies in mothers who are immunized against these antigens ..
  25. Role of P-gp in perivascular HIV-1 sanctuary and HAART
    Debasis Mondal; Fiscal Year: 2007
    ..The proposed studies are expected to provide exploratory new information on existence of a perivascular endothelial barrier that may compromise the effectiveness of Pis and allow development of an HTV-1 sanctuary. ..
  26. Thrombopoietin Signaling: The Role of Src Kinases
    BRIAN LANNUTTI; Fiscal Year: 2007
    ..Understanding the signaling mechanisms of Mp1 and its interactions with other signaling molecules may lead to novel approaches in the treatment of a number of hematologic and other diseases. ..
  27. Orthotopic models of tumor angiogenesis and blood flow
    Meng Yang; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  28. Versatile Mutation Assay Platform
    Stephen Dertinger; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  29. High Throughput Radiation Biodosimetry
    Stephen Dertinger; Fiscal Year: 2007
    ..We propose to develop such a radiation biodosimetry assay based on the extremely high analysis rates that are possible with flow cytometry instrumentation. [unreadable] [unreadable] [unreadable]..
  30. Adenoviral GFP targeting of metastatic human tumors using multiple delivery route
    Hiroyuki Kishimoto; Fiscal Year: 2008
    ..Having obtained these results, we can move forward in the Phase II grant application with experiments to bring OBP-401 to the clinic for use in cancer surgery in human patients. [unreadable] [unreadable] [unreadable]..
  31. Pathophysiologies Involving Hemostasis-related Genes
    Francis Castellino; Fiscal Year: 2008
    ..abstract_text> ..
  32. Regulation of Src by integrins during metastasis
    Jay Desgrosellier; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  33. Glucocorticoids and Programming of the Hypertensive Vascular Phenotype
    Omid Khorram; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  34. Rapid Screen for Genotoxicants, Chemoprotectors, and Radioprotectors
    Stephen Dertinger; Fiscal Year: 2008
    ..In addition, this assay can be used to investigate agents designed to ameliorate the effects of radiation exposure, e.g. biological response modifiers. [unreadable] [unreadable] [unreadable] [unreadable]..
  35. Dissection of cellular interactions with integrated functional genomics in comple
    Martin Hessner; Fiscal Year: 2008
    ..Understanding the relationship between mast cells, T effector, and TREG cells in autoimmunity and has the potential to establish a new paradigm for immune regulation and create new insights to human disease. ..
  36. Targeting Metastatic Breast Cancer with Human Antibodies
    Brunhilde Felding Habermann; Fiscal Year: 2009
    ..Novel immunoconjugates containing small, highly toxic compounds will be tested for their effects on metastatic breast cancer. If successful, this work will contribute to an improvement of current anti-cancer treatment. ..
  37. RHOMOCYCSTEINASE FOR HOMOCYSTEINE ASSAY
    Yuying Tan; Fiscal Year: 2002
    ..The tHCY enzymatic kits for these applications will be ready for commercial launch at this point. PROPOSED COMMERCIAL APPLICATION: Not Available ..
  38. Inhibitors of 5alpha-reductase for acne therapy
    Lingna Li; Fiscal Year: 2002
    ..PROPOSED COMMERCIAL APPLICATIONS: Liposomal 4-MA will be developed as a topical selectively targeted therapeutic for acne for which they should be a very market. ..
  39. ETIOLOGY OF STROKE IN CHILDREN WITH SICKLE CELL DISEASE
    Sherri Zimmerman; Fiscal Year: 2004
    ..Based on this fact-finding study, I will design a hypothesis-driven therapeutic clinical trial for children at highest risk of developing stroke. ..
  40. Molecular Epidemiology of non-Hodgkin Lymphoma Survival
    James R Cerhan; Fiscal Year: 2010
    ..Host genetics may also lead to a better understanding of NHL pathophysiology that could lead to new approaches to improve the survival of NHL patients. ..
  41. Mechanisms of Progesterone Receptor Action in Endometriosis
    JI YONG JULIE KIM; Fiscal Year: 2010
    ..These aims will increase the understanding of progesterone resistance in endometriosis as well as investigate the use of targeted biological agents as an alternate treatment for endometriosis. ..
  42. Measuring Cytogenetic Damage in Human Blood
    Stephen Dertinger; Fiscal Year: 2003
    ..abstract_text> ..
  43. AML1 in Hematopoietic Cell Development
    ROBERT LORSBACH; Fiscal Year: 2006
    ..abstract_text> ..
  44. In vivo mutation assay based on pig-a locus
    Stephen Dertinger; Fiscal Year: 2004
    ....
  45. IVIS 200 Imaging System
    Brunhilde Felding Habermann; Fiscal Year: 2005
    ..abstract_text> ..
  46. Enzyme therapy for hyperhomocysteinemia
    Yuying Tan; Fiscal Year: 2005
    ..Phase II results will lead to an IND for MEGC-PEG-rMETase for end stage renal disease patients and other patients with intractable hyperhomocysteinemia and high cardiovascular disease mortality. ..
  47. TRANSCRIPTION FACTOR NF-E2 IN ALPHA IIB BETA 3 SIGNALING
    SANFORD SHATTIL; Fiscal Year: 2004
    ..abstract_text> ..
  48. AMYLOD BETA-PEPTIDE SPECIFIC scFv ANTIBODIES
    Goar Gevorkian; Fiscal Year: 2005
    ..If successful, these molecules could be of interest for passive immunization in humans, may be after modification with substances that would increase their blood-brain barrier permeability. ..
  49. Human Endometrial Nitric Oxide: Regulation and Function
    Omid Khorram; Fiscal Year: 2003
    ..This pilot study should shed light on regulation and function of human endometrial NO pathway, an uninvestigated area of research with profound clinical significance. ..
  50. Integrin Activation in Breast Cancer Metastasis
    Brunhilde Felding Habermann; Fiscal Year: 2006
    ....
  51. HIGH DENSITY MICROARRAYS WITH QUANTITATIVE QC/QA
    Martin Hessner; Fiscal Year: 2006
    ..Our success will provide an accurate, flexible, lower cost alternative to commercial arrays for laboratories wishing to conduct gene expression studies. ..
  52. Discovery of novel fluorescent reporter genes
    Ming Zhao; Fiscal Year: 2004
    ..Reporters with spectral properties that can be used for whole-body imaging of tumors in the lung and their metastases will be candidates for further development for numerous applications of multi-color imaging. ..
  53. Imageable tumor-targeting bacteria
    Ming Zhao; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  54. Immunogenetics of Non-Hodgkin Lymphoma Survival
    James Cerhan; Fiscal Year: 2006
    ..abstract_text> ..
  55. Targeted tumoricidal bacteria
    Ming Zhao; Fiscal Year: 2007
    ..Future human trials of the tumor-killing bacteria can be held after the Phase I and Phase II grant periods are completed. [unreadable] [unreadable] [unreadable]..
  56. Dual-color tumor-host imaging models
    Meng Yang; Fiscal Year: 2007
    ..These models have significant commercial potential for discovery and development of stroma-targeted and anti-angiogenesis drugs. [unreadable] [unreadable] [unreadable]..
  57. Regulation of Outside-In Integrin Signaling in Platelets
    SANFORD SHATTIL; Fiscal Year: 2007
    ..Thus, this line of investigation may lead to identification of new anti-thrombotic drug targets and serve as a paradigm for integrin signaling in other blood cells. [unreadable] [unreadable] [unreadable]..
  58. Automation of the vitro Micronucleus Assay
    Stephen Dertinger; Fiscal Year: 2004
    ..abstract_text> ..
  59. Molecular analysis of a gene affecting social cognition
    Lauren Weiss; Fiscal Year: 2007
    ..Functional analysis of a gene influencing social cognition could contribute to understanding autism, revealing normal social physiology, and developing methods for the dissection of complex traits. [unreadable] [unreadable] [unreadable]..
  60. Therapeutic hair follicle-derived neurospheres
    Meng Yang; Fiscal Year: 2007
    ..Human hair- follicle bulge cells will be further characterized and developed for therapeutic potential for nerve regeneration in Phase III. [unreadable]..