iNOS

Summary

Gene Symbol: iNOS
Description: nitric oxide synthase 2
Alias: HEP-NOS, INOS, NOS, NOS2A, nitric oxide synthase, inducible, NOS, type II, hepatocyte NOS, inducible NO synthase, inducible NOS, nitric oxide synthase 2, inducible, nitric oxide synthase 2A (inducible, hepatocytes), nitric oxide synthase, macrophage, peptidyl-cysteine S-nitrosylase NOS2
Species: human

Top Publications

  1. ncbi Influence of the inducible nitric oxide synthase gene (NOS2A) on inflammatory bowel disease susceptibility
    M Carmen Martin
    Servicio de Inmunología Clínica, Hospital Clinico San Carlos, 1a planta Sur, C Profesor Martin Lagos s n, 28040 Madrid, Spain
    Immunogenetics 59:833-7. 2007
  2. doi Clinorotation upregulates inducible nitric oxide synthase by inhibiting AP-1 activation in human umbilical vein endothelial cells
    Yong Chun Wang
    Department of Aerospace Biodynamics, Fourth Military Medical University, Xi an, China
    J Cell Biochem 107:357-63. 2009
  3. pmc A functional promoter polymorphism in monocyte chemoattractant protein-1 is associated with increased susceptibility to pulmonary tuberculosis
    Pedro O Flores-Villanueva
    Center for Biomedical Research, University of Texas Health Center at Tyler, Tyler, TX 75708, USA
    J Exp Med 202:1649-58. 2005
  4. pmc S-nitrosation of arginase 1 requires direct interaction with inducible nitric oxide synthase
    Jessilyn Dunn
    Johns Hopkins University School of Medicine, 720 Rutland Ave Ross 1150, Baltimore, MD 21205, USA
    Mol Cell Biochem 355:83-9. 2011
  5. ncbi Heme oxygenase-1 is a critical regulator of nitric oxide production in enterohemorrhagic Escherichia coli-infected human enterocytes
    Marjolaine Vareille
    Institut National de la Recherche Agronomique, Unité de Microbiologie UR454, Saint Genes Champanelle, France
    J Immunol 180:5720-6. 2008
  6. pmc YC-1 stimulates the expression of gaseous monoxide-generating enzymes in vascular smooth muscle cells
    Xiao ming Liu
    Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65212, USA
    Mol Pharmacol 75:208-17. 2009
  7. doi Involvement of Ras and AP-1 in Helicobacter pylori-induced expression of COX-2 and iNOS in gastric epithelial AGS cells
    Soon Ok Cho
    Department of Pharmacology, Brain Korea 21 Project for Medical Sciences, Seoul, 120 752, Korea
    Dig Dis Sci 55:988-96. 2010
  8. ncbi Mechanisms and structural determinants of HIV-1 coat protein, gp41-induced neurotoxicity
    D C Adamson
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Neurosci 19:64-71. 1999
  9. ncbi Endothelial nitric oxide synthase and caveolin-1 are co-localized in sinusoidal endothelial fenestrae
    H Yokomori
    Department of Internal Medicine and Laboratory of Pathology, Kitasato Medical Center Hospital, Saitama and Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Liver 21:198-206. 2001
  10. doi Heme oxygenase-1 expression is down-regulated by angiotensin II and under hypertension in human neutrophils
    Gonzalo Alba
    Departamento de Bioquimica Medica y Biologia Molecular, Facultad de Medicina, Avda Sanchez Pizjuan 4, Universidad de Sevilla, E 41009 Sevilla, Spain
    J Leukoc Biol 84:397-405. 2008

Research Grants

  1. Resolution and repair of acute lung injury by macrophage-derived iNOS
    FRANCO R D'ALESSIO; Fiscal Year: 2011
  2. Franco R D'Alessio; Fiscal Year: 2014
  3. Microanalytical methods for the detection of reactive nitrogen species
    Susan M Lunte; Fiscal Year: 2010
  4. Seena Ajit; Fiscal Year: 2014
  5. THEA NOREEN GOLDEN; Fiscal Year: 2015
  6. New Human Inducible Nitric Oxide Synthase-binding Proteins in Testis: Possible R
    Mohammad B Rashid; Fiscal Year: 2010
  7. Jonathan M Green; Fiscal Year: 2014
  8. ANDREW GREGORY SIKORA; Fiscal Year: 2015
  9. NFkB in the Astrocyte Swelling/Brain Edema with Acute Liver Failure
    MICHAEL DAVID NORENBERG; Fiscal Year: 2012
  10. Angiotensin-induced Oxidants and Vascular Cell Phenotype
    Richard Cohen; Fiscal Year: 2009

Patents

  1. INDUCIBLE NITRIC OXIDE SYNTHASE AND GENE THEREFOR

Detail Information

Publications304 found, 100 shown here

  1. ncbi Influence of the inducible nitric oxide synthase gene (NOS2A) on inflammatory bowel disease susceptibility
    M Carmen Martin
    Servicio de Inmunología Clínica, Hospital Clinico San Carlos, 1a planta Sur, C Profesor Martin Lagos s n, 28040 Madrid, Spain
    Immunogenetics 59:833-7. 2007
    ..This is the first association analysis of polymorphisms within the NOS2A extended gene with IBD susceptibility...
  2. doi Clinorotation upregulates inducible nitric oxide synthase by inhibiting AP-1 activation in human umbilical vein endothelial cells
    Yong Chun Wang
    Department of Aerospace Biodynamics, Fourth Military Medical University, Xi an, China
    J Cell Biochem 107:357-63. 2009
    ..The aim of this study was to investigate the changes of inducible nitric oxide synthase (iNOS) and the mechanisms underlying regulation of iNOS by simulated microgravity in human umbilical vein endothelial ..
  3. pmc A functional promoter polymorphism in monocyte chemoattractant protein-1 is associated with increased susceptibility to pulmonary tuberculosis
    Pedro O Flores-Villanueva
    Center for Biomedical Research, University of Texas Health Center at Tyler, Tyler, TX 75708, USA
    J Exp Med 202:1649-58. 2005
    ..tuberculosis and increases the likelihood that M. tuberculosis infection will progress to active pulmonary tuberculosis...
  4. pmc S-nitrosation of arginase 1 requires direct interaction with inducible nitric oxide synthase
    Jessilyn Dunn
    Johns Hopkins University School of Medicine, 720 Rutland Ave Ross 1150, Baltimore, MD 21205, USA
    Mol Cell Biochem 355:83-9. 2011
    ..Thus, disruption of NOS2-Arg1 interaction may represent a therapeutic strategy to attenuate age related vascular endothelial dysfunction...
  5. ncbi Heme oxygenase-1 is a critical regulator of nitric oxide production in enterohemorrhagic Escherichia coli-infected human enterocytes
    Marjolaine Vareille
    Institut National de la Recherche Agronomique, Unité de Microbiologie UR454, Saint Genes Champanelle, France
    J Immunol 180:5720-6. 2008
    ..b>Inducible NO synthase (iNOS)-derived NO is a critical mediator of the inflammatory response of the infected intestinal mucosa...
  6. pmc YC-1 stimulates the expression of gaseous monoxide-generating enzymes in vascular smooth muscle cells
    Xiao ming Liu
    Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65212, USA
    Mol Pharmacol 75:208-17. 2009
    ..gaseous monoxides by stimulating the expression of the inducible isoforms of heme oxygenase (HO-1) and NO synthase (iNOS) in vascular smooth muscle cells (SMCs)...
  7. doi Involvement of Ras and AP-1 in Helicobacter pylori-induced expression of COX-2 and iNOS in gastric epithelial AGS cells
    Soon Ok Cho
    Department of Pharmacology, Brain Korea 21 Project for Medical Sciences, Seoul, 120 752, Korea
    Dig Dis Sci 55:988-96. 2010
    ..Inflammatory genes including cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) are involved in H. pylori gastritis...
  8. ncbi Mechanisms and structural determinants of HIV-1 coat protein, gp41-induced neurotoxicity
    D C Adamson
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Neurosci 19:64-71. 1999
    ..mixed cortical cultures from neuronal nitric oxide synthase (NOS) null (nNOS-/-) mice and immunological NOS null (iNOS-/-) mice, we establish iNOS-derived NO as a major mediator of gp41 neurotoxicity...
  9. ncbi Endothelial nitric oxide synthase and caveolin-1 are co-localized in sinusoidal endothelial fenestrae
    H Yokomori
    Department of Internal Medicine and Laboratory of Pathology, Kitasato Medical Center Hospital, Saitama and Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Liver 21:198-206. 2001
    Nitric oxide is synthesized in diverse mammalian tissues by a family of calmodulin-dependent nitric oxide synthases (NOS)...
  10. doi Heme oxygenase-1 expression is down-regulated by angiotensin II and under hypertension in human neutrophils
    Gonzalo Alba
    Departamento de Bioquimica Medica y Biologia Molecular, Facultad de Medicina, Avda Sanchez Pizjuan 4, Universidad de Sevilla, E 41009 Sevilla, Spain
    J Leukoc Biol 84:397-405. 2008
    ..15dPGJ2-dependent HO-1 expression in neutrophils from hypertensive patients, and conversely, inhibition of inducible NO synthase (NOS2) activity counteracted the stimulatory effect of 15dPGJ2 on HO-1 expression in normal human ..
  11. pmc A far-upstream Oct-1 motif regulates cytokine-induced transcription of the human inducible nitric oxide synthase gene
    Kyung Soo Park
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Mol Biol 390:595-603. 2009
    ..2 kb in the hiNOS promoter that regulates cytokine-induced hiNOS gene transcription and further underscores tight control mechanisms regulating the expression of the hiNOS gene...
  12. doi Oct-1 cooperates with the TATA binding initiation complex to control rapid transcription of human iNOS
    Sylvie Reveneau
    EPHE Laboratory, Faculty of Medicine, University of Bourgogne, Dijon, France
    Cell Mol Life Sci 69:2609-19. 2012
    ..We propose that, through interaction with the initiation complex, Oct-1 regulates hiNOS transcription by priming the gene for the rapid response required in an immune response...
  13. ncbi The human immunodeficiency virus type 1 regulatory protein Tat inhibits interferon-induced iNos activity in a murine macrophage cell line
    C H Barton
    Department of Biochemistry, University of Southampton, UK
    J Gen Virol 77:1643-7. 1996
    ..whether regulatory HIV-1 proteins, such as Tat, can modulate the activity of the inducible nitric oxide synthase (iNos) gene when expressed in stable transfectant lines of RAW264.7 cells...
  14. ncbi Dedifferentiated human ventricular cardiac myocytes express inducible nitric oxide synthase mRNA but not protein in response to IL-1, TNF, IFNgamma, and LPS
    H Luss
    Department of Surgery, University of Pittsburgh School of Medicine, PA 15261, USA
    J Mol Cell Cardiol 29:1153-65. 1997
    ..The expression of the inflammatory or inducible NO synthase (iNOS) in human cardiac myocytes, however, has not been well characterized...
  15. ncbi Human immunodeficiency virus type 1 Tat protein stimulates inducible nitric oxide synthase expression and nitric oxide production in microglial cultures
    E Polazzi
    Laboratory of Pathophysiology, Istituto Superiore di Sanita, Rome, Italy
    J Neuropathol Exp Neurol 58:825-31. 1999
    ..that the exposure of microglia to Tat led to a dose dependent expression of the inducible isoform of nitric oxide (iNOS) and NO production...
  16. ncbi STAT-1 and c-Fos interaction in nitric oxide synthase-2 gene activation
    Weiling Xu
    Pulmonary and Critical Care Medicine and Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Physiol Lung Cell Mol Physiol 285:L137-48. 2003
    ..9 kb upstream of the transcription start site. Taken together, our findings support a model in which a physical interaction between c-Fos and STAT-1 participates in NOS2 gene transcriptional activation...
  17. ncbi Monosodium urate crystals synergize with IFN-gamma to generate macrophage nitric oxide: involvement of extracellular signal-regulated kinase 1/2 and NF-kappa B
    Maritza Jaramillo
    Centre de Recherche en Infectiologie, Centre Hospitalier Universitaire de Quebec, Pavillon Centre Hospitalier de l Université Laval, and Département de Biologie Médicale Faculté de Médecine, Universite Laval, Ste Foy, Quebec, Canada
    J Immunol 172:5734-42. 2004
    ..urate (MSU) crystals, the causative agent of gout, have been shown to induce NO generation in vivo and inducible NO synthase (iNOS) expression in human monocytes...
  18. ncbi Nitric oxide-dependent negative feedback of PARP-1 trans-activation of the inducible nitric-oxide synthase gene
    Zhiyuan Yu
    Department of Internal Medicine, The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Biol Chem 281:9101-9. 2006
    ..Although mechanisms for cytokine induction of inducible nitric-oxide synthase (iNOS) have been increasingly clarified, the controls for termination of NO production remain unclear...
  19. ncbi Influence of glucosamine sulphate on oxidative stress in human osteoarthritic chondrocytes: effects on HO-1, p22(Phox) and iNOS expression
    C Valvason
    Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Padova, Via Giustiniani, 2 35128 Padova, Italy
    Rheumatology (Oxford) 47:31-5. 2008
    ..The aim of the present study was to investigate the effects of GS on primary human chondrocytes in vitro, in particular with regard to HO-1, p22(Phox) (a subunit of NADPH complex) and inducible nitric oxide synthase (iNOS) expression.
  20. doi Metabolic profile and nitric oxide synthase expression of skeletal muscle fibers are altered in patients with type 1 diabetes
    K Fritzsche
    Institute of Anatomy, University of Leipzig, Germany
    Exp Clin Endocrinol Diabetes 116:606-13. 2008
    ..muscle fiber composition, fiber-specific glycolytic and oxidative enzyme capacity and nitric oxide synthase (NOS) expression in skeletal muscle of patients with type 1 diabetes (T1D) compared to individuals with normal glucose ..
  21. doi Expression of inducible nitric oxide synthase (iNOS) and period 1 (PER1) clock gene products in different sleep stages of patients with cognitive impairment
    Ing Jy Tseng
    College of Nursing, Taipei Medical University, Taipei, Taiwan
    J Clin Neurosci 17:1140-3. 2010
    ..period 1 clock gene product (PER1), which is involved in circadian rhythms, and inducible nitric oxide synthase (iNOS), thought to generate nitric oxide, important in rapid eye movement (REM) sleep regulation...
  22. doi [Expression of iNOS and HIF-1α with angiogenesis in affected skin biopsies from patients with psoriasis]
    Yongjian Li
    Department of Dermatology, The First Affiliated Hospital of Nanhua University, Hengyang Hunan, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 35:952-7. 2010
    To investigate the expression of inducible nitric oxide synthase (iNOS) and hypoxia-inducible factor 1(HIF-1) α in psoriatic lesions,and to explore their relationship with angiogenesis in psoriasis.
  23. ncbi Human retina expresses both constitutive and inducible isoforms of nitric oxide synthase mRNA
    C S Park
    Section of Chemical Pharmacology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1760
    Biochem Biophys Res Commun 205:85-91. 1994
    ..showed more than 99% homology with human brain bNOS and that of riNOS was identical to the chondrocytes inducible iNOS with the exception for one amino acid...
  24. ncbi Expression of nitric oxide synthase in human central nervous system tumors
    C S Cobbs
    Department of Neurological Surgery, University of California, San Francisco 94143
    Cancer Res 55:727-30. 1995
    The nitric oxide synthases (NOS) are a family of related enzymes which regulate the production of NO, a free radical gas implicated in a wide variety of biological processes...
  25. pmc Human immunodeficiency virus 1 envelope proteins induce interleukin 1, tumor necrosis factor alpha, and nitric oxide in glial cultures derived from fetal, neonatal, and adult human brain
    P Koka
    Department of Neurology, University of California, School of Medicine, Los Angeles 90024, USA
    J Exp Med 182:941-51. 1995
    ....
  26. pmc Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes
    D A Geller
    Department of Surgery, University of Pittsburgh, PA 15261
    Proc Natl Acad Sci U S A 90:3491-5. 1993
    ..We now report the molecular cloning and expression of an inducible human hepatocyte NOS (hep-NOS) cDNA. hep-NOS has 80% amino acid sequence homology to macrophage NOS (mac-NOS)...
  27. pmc Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans
    J A Corbett
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110
    Proc Natl Acad Sci U S A 90:1731-5. 1993
    ....
  28. ncbi Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation
    T O Fischmann
    Structural Chemistry Department, Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    Nat Struct Biol 6:233-42. 1999
    Crystal structures of human endothelial nitric oxide synthase (eNOS) and human inducible NOS (iNOS) catalytic domains were solved in complex with the arginine substrate and an inhibitor S-ethylisothiourea (SEITU), respectively...
  29. ncbi Linkage of the human inducible nitric oxide synthase gene to type 1 diabetes
    J Johannesen
    Steno Diabetes Center, DK 2820 Gentofte, Denmark
    J Clin Endocrinol Metab 86:2792-6. 2001
    ..of human pancreatic islets to a mixture of cytokines induces expression of the inducible nitric oxide synthase (iNOS), impairs beta-cell function, and induces apoptosis...
  30. pmc Expression of p53, inducible nitric oxide synthase and vascular endothelial growth factor in gastric precancerous and cancerous lesions: correlation with clinical features
    Chang Wei Feng
    Laboratory for Cancer Research, College of Medicine, Zhengzhou University, Zhengzhou, Henan, China
    BMC Cancer 2:8. 2002
    ..Recent studies indicate that the inducible nitric oxide synthase (iNOS), vascular endothelial growth factor (VEGF) and the tumor suppressor p53 are fundamental play-markers of the ..
  31. ncbi Inducible nitric oxide synthase is expressed in normal human melanocytes but not in melanoma cells in response to tumor necrosis factor-alpha, interferon-gamma, and lipopolysaccharide
    Lothar F Fecker
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Berlin, Germany
    J Invest Dermatol 118:1019-25. 2002
    ....
  32. pmc Human immunodeficiency virus type 1 (HIV-1) tat induces nitric-oxide synthase in human astroglia
    Xiaojuan Liu
    Department of Oral Biology, University of Nebraska Medical Center, Lincoln, Nebraska 68583, USA
    J Biol Chem 277:39312-9. 2002
    ..undertaken to investigate the effect of the HIV-1 tat gene on the expression of inducible nitric-oxide synthase (iNOS) in human U373MG astroglial cells and primary astroglia...
  33. pmc Ubiquitination of inducible nitric oxide synthase is required for its degradation
    Pawel J Kolodziejski
    Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 99:12315-20. 2002
    Inducible nitric oxide synthase (iNOS) is responsible for nitric oxide (NO) synthesis from l-arginine in response to inflammatory mediators. We have previously shown that iNOS is degraded through the 26S proteasome...
  34. ncbi A new NOS2 promoter polymorphism associated with increased nitric oxide production and protection from severe malaria in Tanzanian and Kenyan children
    Maurine R Hobbs
    Department of Internal Medicine, University of Utah and VA Medical Centers, Salt Lake City, UT, USA
    Lancet 360:1468-75. 2002
    Nitric oxide (NO) is a mediator of immunity to malaria, and genetic polymorphisms in the promoter of the inducible NO synthase gene (NOS2) could modulate production of NO...
  35. ncbi Inducible but not endothelial nitric oxide synthase polymorphism is associated with susceptibility to rheumatoid arthritis in northwest Spain
    M A Gonzalez-Gay
    Division of Rheumatology, Hospital Xeral Calde, c Dr Ochoa s n, 27004, Lugo, Spain
    Rheumatology (Oxford) 43:1182-5. 2004
    To assess the influence of inducible and endothelial nitric oxide synthase (iNOS and eNOS) polymorphisms in susceptibility to rheumatoid arthritis (RA).
  36. pmc A novel genetic polymorphism of inducible nitric oxide synthase is associated with an increased risk of gastric cancer
    Jing Shen
    Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Jiangsu Province, China
    World J Gastroenterol 10:3278-83. 2004
    Inducible nitric oxide synthase (iNOS) plays a central role in the pathway of reactive oxygen and nitrogen species metabolism when Helicobacter pylori (H pylori) infection occurs in humans...
  37. ncbi Increased risk of intestinal type of gastric adenocarcinoma in Japanese women associated with long forms of CCTTT pentanucleotide repeat in the inducible nitric oxide synthase promoter
    Masayuki Tatemichi
    International Agency for Research on Cancer, 150 cours Albert Thomas, F 69372 Lyon Cedex 08, France
    Cancer Lett 217:197-202. 2005
    ..number polymorphism of a CCTTT pentanucleotide in the promoter region of the inducible nitric oxide synthase gene (iNOS) and a polymorphism of the interleukin-1beta (IL-1B) promoter at position -31 were analyzed in DNA samples from 181 ..
  38. pmc Inducible nitric oxide synthase, nitrotyrosine and apoptosis in gastric adenocarcinomas and their correlation with a poor survival
    Long Gang Li
    Department of Surgical Oncology, First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning Province, China
    World J Gastroenterol 11:2539-44. 2005
    To detect the presence of inducible nitric oxide synthase (iNOS), nitrotyrosine (NT) and apoptosis in gastric adenocarcinomas and their possible correlations with the clinicopathological characteristics and prognosis of gastric ..
  39. pmc Involvement of KSRP in the post-transcriptional regulation of human iNOS expression-complex interplay of KSRP with TTP and HuR
    Katrin Linker
    Department of Pharmacology, Johannes Gutenberg University, Obere Zahlbacher Strasse 67, D 55101 Mainz, Germany
    Nucleic Acids Res 33:4813-27. 2005
    ..KSRP) as a protein interacting with the 3'-untranslated region (3'-UTR) of the human inducible nitric oxide (iNOS) mRNA. Immunodepletion of KSRP enhanced iNOS 3'-UTR RNA stability in in vitro-degradation assays...
  40. ncbi Association between achalasia and nitric oxide synthase gene polymorphisms
    Fermin Mearin
    Institute of Functional and Motor Digestive Disorders, Centro Medico Teknon, Barcelona, Spain
    Am J Gastroenterol 101:1979-84. 2006
    ..NOS exists in three distinct isoforms: neuronal NOS (nNOS), endothelial NOS (eNOS), and inducible isoform (iNOS). Some studies have shown that NO production is regulated by NOS polymorphisms.
  41. ncbi The polypyrimidine tract-binding protein (PTB) is involved in the post-transcriptional regulation of human inducible nitric oxide synthase expression
    Andrea Pautz
    Department of Pharmacology, Johannes Gutenberg University, Obere Zahlbacher Strasse 67, D 55101 Mainz, Germany
    J Biol Chem 281:32294-302. 2006
    Human inducible nitric oxide synthase (iNOS) expression is regulated by transcriptional and post-transcriptional mechanisms...
  42. ncbi Post-transcriptional regulation of human inducible nitric-oxide synthase expression by the Jun N-terminal kinase
    Riku Korhonen
    Department of Pharmacology, Johannes Gutenberg University, Mainz, Germany
    Mol Pharmacol 71:1427-34. 2007
    Human inducible nitric-oxide synthase (iNOS) expression is regulated both at transcriptional and post-transcriptional levels. In the present study, the effect of Jun N-terminal kinase (JNK) on human iNOS expression was investigated...
  43. ncbi A polymorphism in the inducible nitric oxide synthase gene is associated with tuberculosis
    Luis Miguel Gómez
    Cellular Biology and Immunogenetics Unit, Corporacion para Investigaciones Biologicas CIB, Cra 72 A, No 78 B 141, Medellin, Colombia
    Tuberculosis (Edinb) 87:288-94. 2007
    ..host genetic factors determining the susceptibility to TB, we evaluated the influence of two polymorphisms in the NOS2A gene on the risk of developing pulmonary TB in a Northwestern Colombian population, which is a moderately-high ..
  44. doi Role of inducible nitric oxide synthase in asthma risk and lung function growth during adolescence
    Talat Islam
    Department of Preventive Medicine, USC Keck School of Medicine, University of Southern California, 1540 Alcazar Street, CHP 236, Los Angeles, CA 90033, USA
    Thorax 65:139-45. 2010
    Inducible nitric oxide (NO) synthase (iNOS, encoded by NOS2A) produces NO in response to environmental stimuli, which can result in nitrosative stress...
  45. pmc Genetic variations in nitric oxide synthase and arginase influence exhaled nitric oxide levels in children
    M T Salam
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    Allergy 66:412-9. 2011
    ..In the nitric oxide (NO) synthesis pathway, nitric oxide synthases (encoded by NOS1, NOS2A, and NOS3) and arginases (encoded by ARG1 and ARG2) compete for L-arginine...
  46. doi Inducible nitric oxide synthase expression correlates with angiogenesis, lymphangiogenesis, and poor prognosis in gastric cancer patients
    Wei Zhang
    Wenzhou Medical College, Wenzhou, 325035, China
    Hum Pathol 42:1275-82. 2011
    ..Inducible nitric oxide synthase expression may be a good biomarker for poor prognosis in gastric cancer...
  47. pmc Continuous nitric oxide synthesis by inducible nitric oxide synthase in normal human airway epithelium in vivo
    F H Guo
    Department of Pulmonary and Critical Care Medicine, Cleveland Clinic Foundation, OH 44195, USA
    Proc Natl Acad Sci U S A 92:7809-13. 1995
    ..conclusively demonstrate that NO synthesis in normal human airways is due to the continuous expression of the inducible NOS (iNOS) isoform in airway epithelial cells...
  48. ncbi Pulmonary hypertension in human newborns with congenital diaphragmatic hernia is associated with decreased vascular expression of nitric-oxide synthase
    Sherif M K Shehata
    Department of Pharmacology, Sophia Children s Hospital, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Cell Biochem Biophys 44:147-55. 2006
    ..the expression pattern of NO-generating enzyme nitric-oxide synthase (NOS) (both endothelial [eNOS] and inducible [iNOS] isoforms) in the lungs of CDH patients with PH and evaluated the influence of ECMO on the expression levels of ..
  49. doi Similar regulation of human inducible nitric-oxide synthase expression by different isoforms of the RNA-binding protein AUF1
    Andrea Pautz
    Department of Pharmacology, Johannes Gutenberg University, Mainz, Germany
    J Biol Chem 284:2755-66. 2009
    ..The 3'-untranslated region of the human inducible nitric-oxide synthase (iNOS) contains five AREs, which promote RNA degradation...
  50. doi Nitric oxide synthase isoenzyme expression and activity in peripheral lung tissue of patients with chronic obstructive pulmonary disease
    Caterina Brindicci
    National Heart and Lung Institute, Imperial College London, UK
    Am J Respir Crit Care Med 181:21-30. 2010
    ..However, expression of the NO synthase(s) responsible for elevated NO has not been identified in the peripheral lung tissue of patients with COPD of varying severity...
  51. doi Regulation of the expression of inducible nitric oxide synthase
    Andrea Pautz
    Department of Pharmacology, University Medical Center of the Johannes Gutenberg University Mainz, D 55101 Mainz, Germany
    Nitric Oxide 23:75-93. 2010
    Nitric oxide (NO) generated by the inducible isoform of nitric oxide synthase (iNOS) is involved in complex immunomodulatory and antitumoral mechanisms and has been described to have multiple beneficial microbicidal, antiviral and ..
  52. pmc Increased NOS2 predicts poor survival in estrogen receptor-negative breast cancer patients
    Sharon A Glynn
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
    J Clin Invest 120:3843-54. 2010
    ..Last, pathway analysis linked the tumor NOS2 gene signature to c-Myc activation. Thus, NOS2 is associated with a basal-like transcription pattern and poor survival of ER-negative patients...
  53. ncbi Purification and cDNA sequence of an inducible nitric oxide synthase from a human tumor cell line
    P A Sherman
    Division of Experimental Therapy, Burroughs Wellcome Company, Research Triangle Park, North Carolina 27709
    Biochemistry 32:11600-5. 1993
    ..We have purified the enzyme and examined some of its biochemical properties. An antiserum to an inducible NOS from murine macrophages cross-reacted with the DLD-1 NOS...
  54. ncbi Molecular cloning and structural organization of the human inducible nitric oxide synthase gene (NOS2)
    W Xu
    MRC Molecular Neuroscience Group, Department of Neurobiology, Babraham Institute, Cambridge, UK
    Biochem Biophys Res Commun 219:784-8. 1996
    ..These results differ from the previously reported organization of the iNOS gene, where 26 exons were reported for the genomic structure of NOS2.
  55. ncbi Immunologic NO synthase: elevation in severe AIDS dementia and induction by HIV-1 gp41
    D C Adamson
    Department of Neurology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Pathology 2 210, Baltimore, MD 21287, USA
    Science 274:1917-21. 1996
    ..mediator of neuronal injury, because cytokines may activate the immunologic (type II) isoform of NO synthase (iNOS)...
  56. ncbi Nitric oxide synthase 2(Lambaréné) (G-954C), increased nitric oxide production, and protection against malaria
    J F Kun
    Department of Parasitology, Institute for Tropical Medicine, University of Tubingen, D 72074 Tubingen, Germany
    J Infect Dis 184:330-6. 2001
    ..Ex vivo studies showed that cells isolated from people with this polymorphism have a 7-fold higher baseline NOS activity, compared with the levels detected in cells from subjects with the wild-type gene (P=.003).
  57. ncbi Association of a functional inducible nitric oxide synthase promoter variant with complications in type 2 diabetes
    Brian J Morris
    Basic and Clinical Genomics Laboratory, Department of Physiology and Institute for Biomedical Research, The University of Sydney, New South Wales, 2006, Australia
    J Mol Med (Berl) 80:96-104. 2002
    Complications of diabetes have a genetic influence. Since increased inducible nitric oxide synthase (iNOS) gene ( NOS2A) expression can contribute to tissue damage, NOS2A is a worthy candidate for such a role...
  58. ncbi Nucleotide and haplotypic diversity of the NOS2A promoter region and its relationship to cerebral malaria
    David Burgner
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX2 7BN, UK
    Hum Genet 112:379-86. 2003
    ..critical in the pathogenesis of cerebral malaria, we analysed genetic variation in the proximal promoter region of NOS2A, the gene encoding inducible nitric oxide synthase...
  59. pmc Inducible nitric oxide synthase expression in human colorectal cancer: correlation with tumor angiogenesis
    Fabio Cianchi
    Department of General Surgery, Medical School, University of Florence, Florence, Italy
    Am J Pathol 162:793-801. 2003
    ..in colorectal carcinogenesis, we correlated the expression and the activity of inducible nitric oxide synthase (iNOS) with the degree of tumor angiogenesis in human colorectal cancer...
  60. ncbi Inducible nitric oxide synthase (NOS2) promoter CCTTT repeat polymorphism: relationship to in vivo nitric oxide production/NOS activity in an asymptomatic malaria-endemic population
    Craig S Boutlis
    International Health Program, Infectious Diseases Division, Menzies School of Health Research, Darwin, Northern Territory, Australia
    Am J Trop Med Hyg 69:569-73. 2003
    ..no association between CCTTT repeat number and levels of plasma NO metabolites or peripheral blood mononuclear cell NOS activity in a cohort of asymptomatic malaria-exposed coastal Papua New Guineans 1-60 years old...
  61. ncbi iNOS promoter variants and severe malaria in Ghanaian children
    Jakob P Cramer
    Institute of Tropical Medicine, Charite, Humboldt University, Berlin, Germany
    Trop Med Int Health 9:1074-80. 2004
    ..Polymorphisms in the inducible nitric oxide synthase promoter (iNOS; -954G-->C, -1173C-->T, -2...
  62. pmc Regulation of inducible nitric oxide synthase by rapid cellular turnover and cotranslational down-regulation by dimerization inhibitors
    Pawel J Kolodziejski
    Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:18141-6. 2004
    Overproduction of nitric oxide (NO) by inducible nitric oxide synthase (iNOS) has been implicated in the pathogenesis of many disorders...
  63. pmc Expression of nitric oxide synthase in human gastric carcinoma and its relation to p53, PCNA
    Yong Zhong Wang
    Department of Pathology, The Affiliated Hospital of Jiangsu University, Zhenjiang 212001, Jiangsu Province, China
    World J Gastroenterol 11:46-50. 2005
    To investigate the expression of NOS in gastric carcinoma, and to explore the relationship between the expression of nitric oxide synthases (NOS) and p53, PCNA, pathological features and clinical staging of gastric cancer.
  64. ncbi Nitric oxide synthase 2 (NOS2) promoter polymorphisms in colorectal cancer
    Karin Fransen
    Division of Cell Biology, Floor 9, Department of Biomedicine and Surgery, Faculty of Health Sciences, Linkoping SE 581 85, Sweden
    Cancer Lett 225:99-103. 2005
    ..In conclusion, these results, therefore, suggest that NOS2 promoter polymorphisms have a limited effect on the onset or progression of CRC...
  65. ncbi Expression of inducible nitric oxide synthase is significantly correlated with expression of vascular endothelial growth factor and dendritic cell infiltration in patients with advanced gastric carcinoma
    Kenichi Yamaguchi
    Department of Surgery, Division of Surgical Oncology, Tottori University School of Medicine, Yonago, Japan
    Oncology 68:471-8. 2005
    ..The inducible form of NOS (iNOS) is one of three classes of NOS and the strongest producer of NO...
  66. pmc Protection from Alzheimer's-like disease in the mouse by genetic ablation of inducible nitric oxide synthase
    Carl Nathan
    Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10021, USA
    J Exp Med 202:1163-9. 2005
    Brains from subjects who have Alzheimer's disease (AD) express inducible nitric oxide synthase (iNOS). We tested the hypothesis that iNOS contributes to AD pathogenesis...
  67. ncbi Lack of association between NOS2 pentanucleotide repeat polymorphism and asthma phenotypes or exhaled nitric oxide concentration
    Ting F Leung
    Department of Pediatrics, The Chinese University of Hong Kong, Hong Kong SAR, China
    Pediatr Pulmonol 41:649-55. 2006
    ..949), atopy (P = 0.305), IgE sensitization to aeroallergens (P > 0.2 for all), or FeNO (P = 0.847). These findings do not support NOS2 to be a major candidate gene for asthma or IgE-mediated allergic diseases in Chinese children...
  68. ncbi The NOS3 (27-bp repeat, intron 4) polymorphism is associated with susceptibility to osteomyelitis
    Victor Asensi
    Infectious Diseases Unit, Hospital Central de Asturias, Oviedo University Medical School, Celestino Villamil s n, 33006 Oviedo, Spain
    Nitric Oxide 16:44-53. 2007
    ..044). No significant differences were found for other polymorphisms of the NOS genes such as NOS3, the promoter (-786T/C), and the missense change (E298D) in exon 7, and for NOS2, the G/A ..
  69. ncbi Analysis of the inducible nitric oxide synthase gene polymorphisms in Czech patients with atopic diseases
    L I Holla
    Department of Pathophysiology, Medical Faculty, Masaryk University Brno, Brno, Czech Republic
    Clin Exp Allergy 36:1592-601. 2006
    ..Nitric oxide (NO) is an important mediator of physiologic processes in the airways; it plays a significant role in the regulation of the T helper type 1/type 2 balance and contributes to the development of atopic diseases...
  70. ncbi Polymorphisms of the neuronal and inducible nitric oxide synthase genes and the risk of cutaneous melanoma: a case-control study
    Chunying Li
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 109:1570-8. 2007
    Nitric oxide (NO) is a multifunctional molecule that is produced by both neuronal NO synthase (nNOS) and inducible NO synthase (iNOS), and the expression of nNOS and iNOS is up-regulated in various cancer cells, including cutaneous ..
  71. ncbi Inducible nitric oxide synthase promoter polymorphism, cigarette smoking, and urothelial carcinoma risk
    Cheng huang Shen
    Department of Urology, Chia Yi Christian Hospital, Chia Yi City, Taiwan
    Urology 69:1001-6. 2007
    Bladder carcinoma has a high inducible nitric oxide synthase (iNOS) content, and a highly polymorphic (CCTTT)n repeat in the iNOS promoter region has been identified...
  72. ncbi Inducible nitric oxide synthase: correlation with extracapsular spread and enhancement of tumor cell invasion in head and neck squamous cell carcinoma
    Peter A Brennan
    Department of Maxillofacial Head and Neck Surgery, Queen Alexandra Hospital, Portsmouth PO6 3LY, United Kingdom
    Head Neck 30:208-14. 2008
    ..Nitric oxide (NO), primarily produced by the enzyme inducible NO synthase (iNOS), has a large number of actions in cancer biology, but no studies have investigated its possible ..
  73. doi Genetic polymorphisms in mediators of inflammation and gastric precancerous lesions
    Federico Canzian
    German Cancer Research Center DKFZ, Heidelberg, Germany
    Eur J Cancer Prev 17:178-83. 2008
    ..nucleotide polymorphisms (SNPs) in cyclooxygenase 1 and 2 (PTGS1 and PTGS2), inducible nitric oxide synthase (NOS2A), interferon gamma (IFNG) and its receptor (IFNGR1), and risk of gastric precancerous lesions in a Venezuelan ..
  74. doi Cyclooxygenase-2 and inducible nitric oxide synthase gene polymorphisms and risk of reflux esophagitis, Barrett's esophagus, and esophageal adenocarcinoma
    Heather R Ferguson
    Division of Gastroenterology, Belfast City Hospital, Belfast, United Kingdom
    Cancer Epidemiol Biomarkers Prev 17:727-31. 2008
    ..through activation of "prosurvival genes," including cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS)...
  75. pmc Genetic variation in nitric oxide synthase 2A (NOS2A) and risk for multiple sclerosis
    L F Barcellos
    Division of Epidemiology, School of Public Health, University of California, Berkeley, CA 94720 7356, USA
    Genes Immun 9:493-500. 2008
    ..Previous evidence has implicated the nitric oxide synthase gene (NOS2A) encoding inducible NOS on chromosome 17q11 as a potential MS susceptibility gene...
  76. pmc Nitric oxide synthase gene polymorphisms and prostate cancer risk
    Kyoung Mu Lee
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Carcinogenesis 30:621-5. 2009
    ..evaluated the association of prostate cancer with genetic polymorphisms in two genes related to intracellular NO: NOS2A [inducible nitric oxide synthase (NOS); -2892T>C, Ex16 + 14C>T (S608L), IVS16 + 88T>G and IVS20 + 524G>..
  77. doi Single nucleotide polymorphisms in the NOS2 and NOS3 genes are associated with exhaled nitric oxide
    Santosh Dahgam
    Occupational and Environmental Medicine, University of Gothenburg, Gothenburg, Sweden
    J Med Genet 49:200-5. 2012
    ..However, the genetic contribution of NOS polymorphisms to FENO is not fully understood...
  78. ncbi Differential expression of nitric oxide synthases (NOS 1-3) in human skeletal muscle following exercise countermeasure during 12 weeks of bed rest
    Jana Rudnick
    Department of Anatomy, Campus Benjamin Franklin, Charite University Medicine Berlin, Germany
    FASEB J 18:1228-30. 2004
    ..linked to muscle activity, we investigated altered expression of the three major isoforms of nitric oxide synthase (NOS 1-3) at cellular compartments during prolonged HDT BR without (control group) and with resistance exercise ..
  79. ncbi Polymorphisms in oxidative stress genes and risk for non-Hodgkin lymphoma
    Sophia S Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA
    Carcinogenesis 27:1828-34. 2006
    ..Thirteen single nucleotide polymorphisms (SNPs) from 10 oxidative stress genes (AKR1A1, AKR1C1, CYBA, GPX, MPO, NOS2A, NOS3, OGG1, PPARG and SOD2) were genotyped in 1172 NHL cases and 982 population-based controls from a USA ..
  80. ncbi Human immunodeficiency virus-1-infected macrophages induce inducible nitric oxide synthase and nitric oxide (NO) production in astrocytes: astrocytic NO as a possible mediator of neural damage in acquired immunodeficiency syndrome
    K Hori
    Division of Cytokine Biology and the Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD, USA
    Blood 93:1843-50. 1999
    ..monocyte-derived macrophages (MDM) produce low levels of NO in vitro and that inducible nitric oxide synthase (iNOS) is expressed in the brain of patients with neurologic disease...
  81. pmc Inhibition of rat colon contractility by prostacyclin (IP-) receptor agonists: involvement of NANC neurotransmission
    Y M Qian
    Department of Pharmacology, Faculty of Medicine, Chinese University of Hong Kong, Shatin, NT
    Br J Pharmacol 115:163-71. 1995
    ..3. A transmitter role for nitric oxide was investigated. The nitric oxide synthase (NOS) inhibitor N omega-nitro-L-arginine methyl ester (L-NAME, 100 microM) inhibited the actions of both cicaprost (10 ..
  82. pmc Comparison of effects of chronic and acute administration of NG-nitro-L-arginine methyl ester to the rat on inhibition of nitric oxide-mediated responses
    C E Bryant
    William Harvey Research Institute, Medical College of Saint Bartholomew s Hospital, London
    Br J Pharmacol 114:1673-9. 1995
    ..The resistance of peripheral neuronal NO responses to chronic treatment with L-NAME indicates that selective inhibition of different isoforms of NOS may be achieved in vivo.
  83. pmc Involvement of tyrosine kinase in the induction of cyclo-oxygenase and nitric oxide synthase by endotoxin in cultured cells
    P Akarasereenont
    William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
    Br J Pharmacol 113:1522-8. 1994
    ..COX) and nitric oxide synthase (NOS) are two enzymes which have distinct cytokine-inducible isoforms (COX-2 and iNOS). Many cytokine receptors have an intracellular tyrosine kinase domain...
  84. pmc Inhibition by N-acetyl-5-hydroxytryptamine of nitric oxide synthase expression in cultured cells and in the anaesthetized rat
    P Klemm
    William Harvey Research Institute, St Bartholomew s Hospital Medical College, Charterhouse Square, London
    Br J Pharmacol 115:1175-81. 1995
    1. Induction of the calcium-independent isoform of nitric oxide (NO) synthase (iNOS) in various cell types has been implicated in the circulatory failure in experimental models of septic shock...
  85. pmc Involvement of nitric oxide in the endothelium-dependent relaxation induced by hydrogen peroxide in the rabbit aorta
    A Zembowicz
    Department of Pharmacology, Copernicus Academy of Medicine, , Poland
    Br J Pharmacol 110:151-8. 1993
    ..methyl ester (L-NAME, 30 microM) or NG-monomethyl-L-arginine (300 microM), inhibitors of nitric oxide synthase (NOS), in a manner that was reversible by L-, but not by D-arginine (2mM)...
  86. pmc Regulation of prostaglandin production by nitric oxide; an in vivo analysis
    D Salvemini
    G D Searle, Department of Molecular Pharmacology, St Louis, MO 63167, USA
    Br J Pharmacol 114:1171-8. 1995
    ..Inducible cyclo-oxygenase (COX-2) and nitric oxide synthase (iNOS) expression accounted for the LPS-induced PG and NO release since the glucocorticoid, dexamethasone inhibited both ..
  87. ncbi Overexpression of protein kinase C-zeta isoform increases cyclooxygenase-2 and inducible nitric oxide synthase
    B W Miller
    Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA
    Am J Physiol 273:C130-6. 1997
    ..Both of these enzymes have inducible forms [COX-2 and inducible nitric oxide synthase (iNOS), respectively] that respond to environmental stresses, chemicals, and extracellular ligands such as interleukin-1, ..
  88. pmc Group B Streptococcus and E. coli LPS-induced NO-dependent hyporesponsiveness to noradrenaline in isolated intrapulmonary arteries of neonatal piglets
    E Villamor
    Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain
    Br J Pharmacol 115:261-6. 1995
    ..NA) in isolated pulmonary arteries and on the activity of the constitutive and inducible nitric oxide synthase (NOS) in lung fragments of neonatal piglets. 2...
  89. pmc Platelet-activating factor: the effector of protein-rich plasma extravasation and nitric oxide synthase induction in rat immune complex peritonitis
    A A Steil
    Departamento de Bioquimica y Fisiologia CSIC, Facultad de Medicina, Valladolid, Spain
    Br J Pharmacol 114:895-901. 1995
    ..9. Study by Northen blotting of mRNA coding for the inducible NO synthase (iNOS) showed transcription at 6 and 18 h after the induction of RPA, which was inhibited in UR-12460-..
  90. ncbi Reduction of myocardial infarct size by inhibition of inducible nitric oxide synthase
    D Wang
    Department of Medicine, and Heart and Vascular Institute, Henry Ford Hospital, Detroit, Michigan 48202-2689, USA
    Am J Hypertens 12:174-82. 1999
    The inducible nitric oxide synthase isoform (iNOS) is upregulated by cytokines and endotoxins in many types of cells, including cardiac myocytes...
  91. pmc An investigation of some S-nitrosothiols, and of hydroxy-arginine, on the mouse anococcygeus
    A Gibson
    Smooth Muscle Pharmacology Group, King s College London
    Br J Pharmacol 107:715-21. 1992
    ..The relaxations were unaffected by the nitric oxide synthase (NOS) inhibitor, L-NG-nitro-arginine (10 microM) (L-NOARG). 3...
  92. pmc Delayed circulatory failure due to the induction of nitric oxide synthase by lipoteichoic acid from Staphylococcus aureus in anaesthetized rats
    S J De Kimpe
    William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
    Br J Pharmacol 114:1317-23. 1995
    ..Staphylococcus aureus, a micro-organism without endotoxin, on haemodynamics and induction of nitric oxide synthase (iNOS) in the anaesthetized rat. 2...
  93. pmc Inhibition of nitric oxide synthesis in vascular smooth muscle by retinoids
    K Hirokawa
    Department of Clinical Pharmacology, Royal Postgraduate Medical School, London
    Br J Pharmacol 113:1448-54. 1994
    ..actions of retinoids are mediated by induction of transforming growth factor beta (TGF-beta), its effect on inducible NOS activity in VSM cells was examined. TGF-beta produced concentration-dependent (0...
  94. ncbi Endothelin and blood pressure regulation in the female rat: studies in normal pregnancy and with nitric oxide synthase inhibition-induced hypertension
    L G Thaete
    Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Northwestern University Medical School, Evanston Northwestern Healthcare, IL 60201, USA
    Hypertens Pregnancy 19:233-47. 2000
    ..ET) in blood pressure regulation in normal pregnant and nonpregnant rats and with nitric oxide synthase (NOS) inhibition...
  95. pmc Nitric oxide-mediated hyporeactivity to noradrenaline precedes the induction of nitric oxide synthase in endotoxin shock
    C Szabo
    William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
    Br J Pharmacol 108:786-92. 1993
    ..The role of an enhanced formation of nitric oxide (NO) and the relative importance of the constitutive and inducible NO synthase (NOS) for the development of immediate (within 60 min) and delayed (at 180 min) vascular hyporeactivity to ..
  96. pmc Characterization of the novel nitric oxide synthase inhibitor 7-nitro indazole and related indazoles: antinociceptive and cardiovascular effects
    P K Moore
    Biomedical Sciences Division, King s College, University of London
    Br J Pharmacol 110:219-24. 1993
    ..induced antinociception in the mouse was correlated with inhibition of brain (cerebellum) nitric oxide synthase (NOS) activity. Maximum antinociceptive activity and NOS inhibition was detected 18-30 min following i.p. administration...
  97. ncbi Vasoactive hormones induce nitric oxide synthase mRNA expression and nitric oxide production in human endothelial cells and monocytes
    M Schena
    Department of Medicine and Experimental Oncology, University of Turin, Italy
    Am J Hypertens 12:388-97. 1999
    ..Human endothelial cells and monocytes express the NOS-2 and NOS-3 mRNA and the inducible NOS-2 mRNA expression increases after vasoactive hormone stimulation.
  98. pmc Inhibition of rat cerebellar nitric oxide synthase by 7-nitro indazole and related substituted indazoles
    R C Babbedge
    Biomedical Sciences Division, King s College, University of London
    Br J Pharmacol 110:225-8. 1993
    1. 7-Nitro indazole (7-NI) produces potent inhibition of rat cerebellar nitric oxide synthase (NOS) with an IC50 of 0.9 +/- 0.1 microM (n = 6). NOS activity is dependent on the presence of both exogenous CaCl2 and NADPH...
  99. pmc Relaxin-induced increased coronary flow through stimulation of nitric oxide production
    T Bani Sacchi
    Department of Human Anatomy and Histology, University of Florence, Italy
    Br J Pharmacol 116:1589-94. 1995
    ..nitrite in the perfusates induced by RLX was significantly reduced by pretreatment with the nitric oxide synthase (NOS) inhibitor, NG-monomethyl-L-arginine (L-NMMA, 10(-4) M). 4...
  100. ncbi Protein kinase C independent activation of inducible nitric oxide synthase by tumor necrosis factor-alpha in TM4 Sertoli cells
    C K Chung
    Department of Food and Nutrition, Hallym University, Chunchon, South Korea
    Immunopharmacol Immunotoxicol 22:49-59. 2000
    ..RIFN-gamma in combination with rTNF-alpha showed marked increase of the expression of iNOS protein. Protein kinase C inhibitors did not inhibit the production of NO induced by rIFN-gamma plus rTNF-alpha...
  101. pmc Neuronal nitric oxide synthase expression is induced in neocortical astrocytes after spreading depression
    A O Caggiano
    Department of Neurology, University of Chicago, IL 60637, USA
    J Cereb Blood Flow Metab 18:75-87. 1998
    ..05 and 0.01, respectively), whereas inducible NOS expression remained unchanged...

Research Grants83

  1. Resolution and repair of acute lung injury by macrophage-derived iNOS
    FRANCO R D'ALESSIO; Fiscal Year: 2011
    ..Consistent with the increase in NOx, we found that inducible nitric oxide synthase (iNOS) protein expression was significantly upregulated in the lung and peaked at day 4 after injury...
  2. Franco R D'Alessio; Fiscal Year: 2014
    ..Consistent with the increase in NOx, we found that inducible nitric oxide synthase (iNOS) protein expression was significantly upregulated in the lung and peaked at day 4 after injury...
  3. Microanalytical methods for the detection of reactive nitrogen species
    Susan M Lunte; Fiscal Year: 2010
    ..released by astrocytes during infection or inflammation cause the induction of inducible nitric oxide synthase (iNOS), which results in the release of large amounts of nitric oxide into the neurovascular space...
  4. Seena Ajit; Fiscal Year: 2014
    ..hsa-miR-939 target mRNAs including vascular endothelial growth factor A (VEGFA), inducible nitric oxide synthase (NOS2A), and tumor necrosis factor alpha (TNFalpha) to assess if downregulation of hsa-miR- 939 can result in the ..
  5. THEA NOREEN GOLDEN; Fiscal Year: 2015
    ..During inflammation, NO production is increased via upregulation of inducible nitric oxide synthase (iNOS) expression in leukocytes and epithelial cells...
  6. New Human Inducible Nitric Oxide Synthase-binding Proteins in Testis: Possible R
    Mohammad B Rashid; Fiscal Year: 2010
    ..Like constitutive NOSs, inducible nitric oxide synthase (iNOS) also takes part in protein-protein interaction...
  7. Jonathan M Green; Fiscal Year: 2014
    ..In this application, we propose cellular, molecular and in vivo studies to determine the mechanism of the novel mode of action for CTLA4Ig., which may have broad applicability to therapeutic manipulation of inflammatory lung disease ..
  8. ANDREW GREGORY SIKORA; Fiscal Year: 2015
    ..through a variety of mechanisms including production of nitric oxide (NO) by inducible nitric oxide synthase (iNOS)...
  9. NFkB in the Astrocyte Swelling/Brain Edema with Acute Liver Failure
    MICHAEL DAVID NORENBERG; Fiscal Year: 2012
    ..cell swelling, along with their interaction with inflammatory enzymes, including inducible nitric oxide synthase (iNOS), phospholipase A2 (PLA2), and cyclooxygenase-2 (COX-2) that are regulated by NF-kB, will be investigated...
  10. Angiotensin-induced Oxidants and Vascular Cell Phenotype
    Richard Cohen; Fiscal Year: 2009
    ..response is associated with intense nitrotyrosine (NY) staining, indicating that NO derived from eNOS and/or iNOS is inactivated by insufficiently scavenged O2 to form the RNS, peroxynitrite (ONOO)...
  11. Hepatocyte Nitric Oxide Synthase Regulation by Glucagon and Insulin
    Brian G Harbrecht; Fiscal Year: 2012
    ..NO is produced in hepatocytes by the inducible nitric oxide synthase (iNOS) that is stimulated by cytokines and proinflammatory stimuli...
  12. Harvey E Marshall; Fiscal Year: 2016
    ..In this regard, LPS-induced NF-(B activity and airway inflammation is augmented in the lungs of inducible NOS (NOS2)-null (KO) mice and diminished in the lungs of GSNOR KO mice...
  13. Keer Sun; Fiscal Year: 2016
    ..Therefore, both NOX2 and inducible nitric oxide synthase (iNOS) activities critically contribute to oxidative stress which has long been known to be involved in inflammatory lung ..
  14. Lipid peroxidation-induced chemical modifications of insulin signaling proteins
    Krisztian Stadler; Fiscal Year: 2012
    ..species (ROS/RNS) in the disease, with increasing evidence for the involvement of inducible nitric oxide synthase (iNOS) and the deleterious peroxynitrite...
  15. Radical Intermediates of Nitric Oxide Synthase &Myocardial Ischemia Reperfusion
    Ah Lim Tsai; Fiscal Year: 2013
    ..preventing BH4 oxidation in all NOS isoforms but is also necessary for keeping structural integrity of the nNOS and iNOS. Similar RFQ EPR kinetic measurements will be conducted in the presence and absence of thiol...
  16. Jun Xu; Fiscal Year: 2015
    ....
  17. Richard B Silverman; Fiscal Year: 2016
    ..their potency and selectivity for nNOS over the other two isoforms of NOS, endothelial NOS (eNOS) and inducible NOS (iNOS) to minimize side effects and toxicities...
  18. Targeting of Interferon-induced host proteins to Legionella-containing vacuoles
    JOERN COERS; Fiscal Year: 2013
    ..This knowledge will open up avenues for the development of novel therapeutics that aim to boost the inherent ability of the host organism to detect and eliminate intracellular bacterial pathogens. ..
  19. Immunosuppression by Adult Stem Cells
    Yufang Shi; Fiscal Year: 2013
    ..Such cytokine pairs provoked MSCs to express inducible nitric oxide synthase (iNOS), produce NO, and secrete of large amounts of T cell specific-chemokines, which complement the activity of NO: in ..
  20. Intrauterine hypoxia induces cytokine gene expression in fetal cardiac ventricles
    LASHAUNA C EVANS; Fiscal Year: 2010
    ..has been reported to upregulate the oxygen- sensitive gene expression of both inducible nitric oxide synthase (iNOS) and proinflammatory cytokines...
  21. Brian M Polster; Fiscal Year: 2016
    ..the central hypothesis that at brain physiological O2, NO derived from microglial inducible nitric oxide synthase (iNOS) causes cortical neuron injury by S-nitrosylation-mediated inactivation of succinate dehydrogenase upstream of ..
  22. Claude A Piantadosi; Fiscal Year: 2016
    ..Understanding these fundamental regulatory mechanisms is needed to design forward-thinking therapeutic approaches to protect mitochondrial quality control during sepsis. ..
  23. Plasma iNOS IVD Prognosticates Sepsis Prior to Organ Damage and Dysfunction
    Robert J Webber; Fiscal Year: 2010
    ..can be completed in 36 months or less will be conducted on our IVD test for plasma inducible nitric oxide synthase (iNOS) as an accurate and reliable plasma biomarker for detecting early the onset of sepsis in trauma patients by ..
  24. The role of lymphatic contraction in inflammation and cancer metastasis
    Shan Liao; Fiscal Year: 2013
    ..areas attenuated collecting lymphatic vessel contraction via expression of inducible nitric oxide synthase (iNOS)...
  25. Role of reactive intermediates in lupus nephritis
    James C Oates; Fiscal Year: 2012
    ..However ablation of the inducible NOS gene in a murine lupus model does not prevent renal disease, suggesting that iNOS is not the only enzyme ..
  26. Tong Wu; Fiscal Year: 2016
    ..that transactivation of EGFR by EP1 is crucial for activation of 2-catenin and inducible nitric oxide synthase (iNOS) and that the interactions of these key molecules perpetuate bile duct inflammation and drive carcinogenesis...
  27. Eicosanoid Regulation in Atherosclerosis: Involvement of Inducible NO Synthase
    David P Hajjar; Fiscal Year: 2010
    ..Notably, the inducible forms of PGHS (PGHS-2) and nitric oxide synthase (iNOS) are increased and co-localize in atherosclerotic lesions and recent developments show that both enzymes bind...
  28. High-Resolution 3D Ultrasound Imaging &Quantification of Murine Cardiac Function
    John A Hossack; Fiscal Year: 2012
    ..post-MI (as detected by high-resolution ultrasound) will be reduced in inducible Nitric Oxide Synthase (iNOS) knock out (KO) mice. The Specific Aims are to: A...
  29. Timothy L Ratliff; Fiscal Year: 2014
    ..Only tumor- or inflammation-derived MDSC to express Arginase I (Arg-I) and inducible nitric oxide synthase (iNOS) and suppress T cell responses, clearly localizing functional MDSC to active inflammatory sites...
  30. Role of Nitric Oxide in Radiation-Induced Lung Injury
    Rama Malaviya; Fiscal Year: 2013
    ..For these studies 1400W, a highly specific inhibitor of inducible nitric oxide synthase (iNOS), which has previously been shown to be effective in ameliorating acute lung injury in rodent models will be used...
  31. Carlos S Subauste; Fiscal Year: 2014
    ..The proposed work may lead to new strategies to treat diabetic retinopathy. ..
  32. SHELLY CHI LOO LU; Fiscal Year: 2016
    ..How SAMe affects histone methylation and acetylation to regulate TNF1 and iNOS expression will be examined. 3. Examine how altered SAMe metabolism affects the susceptibility to liver injury...
  33. A Mouse Model of Inflammation in Alzheimer's Disease
    Carol Anne Colton; Fiscal Year: 2013
    ..PUBLIC HEALTH REVELANCE: This project will examine the role of the brain's innate immune state in generating the neuropathology associated with chronic neurodegenerative diseases such as Alzheimer's disease. ..
  34. Regulatory Mechanisms of Oxidative Stress in Cardiac Angiogenesis Postinfarction
    Yao Sun; Fiscal Year: 2013
    ..artery ligation in Sprague-Dawley (SD) rats with pharmacological intervention;inducible nitric oxide synthase (iNOS) gene knockout mice;and cultured endothelial cells, we intend to fulfill the following specific aims: Specific Aim ..
  35. Mechanism of Vascular Remodeling in Hyperhomocysteinemia
    Suresh C Tyagi; Fiscal Year: 2010
    ..e. CBS +/+, CBS - /+ and CBS -/-), PPARy-/+, iNOS-/-, p47-/-, MMP-9-/- and double knockout mice. Aortic PPARy activity will be measured by EMSA...
  36. Mechanisms and Regulation of Inducible Nitric Oxide Synthase
    JOSEPH EDWARD SABAT; Fiscal Year: 2010
    Inducible Nitric Oxide Synthase (iNOS) converts L-arginine to L-citrulline and NO using two molecules of oxygen and a tetrahydrobiopterin cofactor...
  37. Suresh C Tyagi; Fiscal Year: 2016
    ..heart failure will be created by LV volume overload by aorta-venacava fistula (AVF) in wild type (WT), PAR-1-/+, iNOS-/-, MMP-9-/-, TIMP-3-/-, and TIMP-4++/++ mice, treated with or without NaHS, a H2S donor. PHS 398/2590 (Rev...
  38. Novel Therapeutic Targets in Necrotizing Enterocolitis
    Peter J Giannone; Fiscal Year: 2012
    ....
  39. ASS, NOS2, AND ALCOHOLIC LIVER DISEASE
    Natalia Nieto; Fiscal Year: 2012
    ..Such information could lead to positive pharmacological targeting to ameliorate alcohol hepatotoxicity. ..
  40. John A Auchampach; Fiscal Year: 2016
    ..NOS isoforms (eNOS, nNOS or iNOS) and their signaling pathways activated by the EETs will be identified...
  41. Role of iNOS, Nitric Oxide &Arginase in Statin-Mediated Toxicity in Cancer Cells
    Balaraman Kalyanaraman; Fiscal Year: 2012
    ..cytotoxicity to breast cancer cells through either increased expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) and/or decreased arginase expression...
  42. Combinational Approaches to the Chemoprevention of Esophageal Cancer
    Tong Chen; Fiscal Year: 2012
    ..hypothesis is that combination of cyclooxygenase-2 (COX-2) inhibitor, celecoxib, inducible nitric oxide synthase (iNOS) inhibitor, S,S'-1,4- phenylene-bis(1,2-ethanediyl)bis-isothiourea (PBIT), and freeze-dried black raspberries (..
  43. Pharmacological vaccine adjuvants: analysis of immune responses to vaccines
    Jeannine M Durdik; Fiscal Year: 2010
    ..of pharmacological vaccine adjuvants: phosphodiesterase (PDE) inhibitors and inducible nitric oxide synthase (iNOS) inhibitors when given concurrently with immunization enhance immune memory...
  44. Structural/Functional Modularity in Nitric Oxide Synthase
    Linda J Roman; Fiscal Year: 2012
    ..that govern the functional behavior of the nitric oxide synthase (NOS) isoforms, neuronal NOS (nNOS), inducible NOS (iNOS) and endothelial NOS (eNOS), in their respective environments...
  45. Structural Contexts and Functional Consequences of Protein S-nitrosylation
    Eric R Schreiter; Fiscal Year: 2010
    ..and we have previously demonstrated via X-ray crystallography that the tetrahydrobiopterin cofactor of inducible NOS (iNOS) can undergo a novel N-nitrosylation...
  46. Inhibition of NO Dependent Splanchnic Hyperemia Improves CFS/POTS
    ANTHONY JAMES OCON; Fiscal Year: 2012
    ..We hypothesize that CFS/POTS is caused by either increased neuronal NOS activity (nNOS, NOS-1) or increased inducible NOS (INOS, NOS-2), that there is evidence for increased NOS expression at tissue level, and that inhibition of NO-..
  47. Robert W McCarley; Fiscal Year: 2016
    ..We will test our preliminary data-derived hypothesis indicating that inducible nitric oxide synthase (iNOS)-produced nitric oxide (NO) is an immediate mediator of AD increases during SD, and we predict that iNOS and NO ..
  48. The amyloid cascade in a novel mouse model of Alzheimer's disease
    Carol Anne Colton; Fiscal Year: 2013
    ..The second aim will examine the role of NOS2. We propose a) to reduce brain iNOS protein using lentivirus delivery of small interfering RNA (shNOS2 lentivirus) b) to test the ability of NOS2 and ..
  49. Osteopontin regulates ubiquitin-proteasome degradation of STAT1
    Paul C Kuo; Fiscal Year: 2012
    Expression of inducible nitric oxide synthase (iNOS) is central to many of the systemic effects associated with sepsis...
  50. Nuclear EGFR Signaling Network in Human Cancer
    Hui Wen Lo; Fiscal Year: 2010
    ..and activator of transcription-3, STATS, leading to increased expression of inducible nitric oxide synthase (iNOS). Aim 1 will characterize nuclear EGFR/STAT3 interaction and determine its role in iNOS gene regulation...
  51. Limin Liu; Fiscal Year: 2014
    ..conditions that predispose to HCC, liver cells often highly express the inducible nitric oxide synthase (iNOS), although the role of NO in HCC is unknown...
  52. Glial cell regulation of blood flow in the normal and diabetic retina
    Eric A Newman; Fiscal Year: 2013
    ..retina, and iii) whether functional hyperemia can be restored by inhibiting inducible nitric oxide synthase (iNOS). Experiments will be conducted on the rat intact-globe in vivo preparation...
  53. Anna Kalinchuk; Fiscal Year: 2016
    ..triggered in the BF during SD and promotes RS: it begins with a rapid induction of inducible nitric oxide synthase (iNOS) followed by the increases in NO and extracellular adenosine [AD]ex, first in the BF (1-3h SD) and later in the ..
  54. Small molecular weight eNOS inhibitors for the treatment of pancreatic cancer
    CHRISTOPHER COUNTER; Fiscal Year: 2012
    ..this end, we discovered eNOS, one of three proteins in the Nitric Oxide Synthase family (composed of eNOS, nNOS and iNOS) that generate nitric oxide (NO), mediates oncogenic KRAS tumorigenesis...
  55. Gene Delivery Stents
    Robert J Levy; Fiscal Year: 2013
    ..Our therapeutic vector will include rat inducible nitric oxide synthase (iNOS) with the rat arterial smooth muscle cell specific SM22alpha promoter, to both target smooth muscle cells and to ..
  56. Zvonimir S Katusic; Fiscal Year: 2016
    ..be followed by in vivo testing of the proposed hypothesis in genetically modified mice including eNOS, nNOS-, and iNOS-deficient mice, [unreadable]1 or [unreadable]1 isoform of soluble guanylate cyclase-deficient mice, and endothelial ..
  57. NITRIC OXIDE AND HEPATIC FUNCTION IN SEPSIS AND TRAUMA
    Timothy R Billiar; Fiscal Year: 2012
    ..We have discoveredthat the inducible nitric oxide synthase (iNOS) translocates to the peroxisome in hepatocytes. This enzyme exhibits decreasedspecific activity...
  58. Creating a mouse model for neurodegenerative disease by "humanizing" NOS2
    Carol Anne Colton; Fiscal Year: 2010
    ..NOS2 and its gene product, iNOS play an important role in neuroinflammation by generating nitric oxide (NO), a critical signaling and redox factor ..
  59. Dendritic cells in psoriasis and effects of efalizumab
    Michelle A Lowes; Fiscal Year: 2010
    ..It also expresses TNF and iNOS, so these cells may be the human equivalent of recently described murine TNF- and indicible nitric oxide synthase (..
  60. Targeting Brain Tumor Stem Cells
    CHRISTINE ELISSA EYLER; Fiscal Year: 2010
    ..expressed in a variety of cancers, including malignant brain cancers, the role of inducible nitric oxide synthase (iNOS) in tumors is unclear, since several pro- and anti-tumorigenic roles of NO and iNOS have been delineated in various ..
  61. NITRIC-OXIDE SYNTHASE FORMS N-NO-PTERIN AND S-NO-CYS
    ELIZABETH GETZOFF; Fiscal Year: 2011
    ..Inducible nitric-oxide synthase (iNOS) produces biologically stressful levels of nitric oxide (NO) as a potent mediator of cellular cytotoxicity or ..
  62. Nitric oxide signaling in healthy and diseased cardiac myocytes
    Mark T Ziolo; Fiscal Year: 2013
    ..We propose to investigate an isoform that produces nitric oxide, inducible nitric oxide synthase-NOS^ Which is not expressed in healthy myocytes...
  63. Variation in M. tuberculosis in response to host selection
    Sarah Fortune; Fiscal Year: 2009
    ..In these studies, we expect to provide fundamental insights into the mechanisms and targets of diversifying immune selection in M. tuberculosis. ..
  64. Keith T Wilson; Fiscal Year: 2016
    ..pylori. L-Arg is the common substrate for two divergent enzymatic pathways: inducible nitric oxide (NO) synthase (iNOS), that generates high output NO;and arginase, consisting of two forms, arginase I (Arg1) and arginase II (Arg2) ..
  65. Endothelial reactivity and nitric oxide synthetase activity in the ALMS (Aspreva
    Robert Clancy; Fiscal Year: 2009
    ..Relevance to public health: The association of markers/indices of NOS2 expression with mechanism of action of a successful drug treatment in lupus nephritis would be a major advance. ..
  66. Inducible Nitric Oxide Synthase and Insulin Resistance
    Masao Kaneki; Fiscal Year: 2009
    ..objectives of this project are to clarify the molecular mechanisms by which inducible nitric oxide synthase (iNOS) mediates insulin resistance...
  67. SEPTIC SHOCK IN NITRIC OXIDE SYNTHASE DEFICIENT MICE
    Carl Nathan; Fiscal Year: 1999
    ..have proposed that a major cause of shock in sepsis is expression of the enzyme inducible nitric oxide synthase (iNOS). Bacterial products and cytokines induce iNOS expression...
  68. REGULATION OF INDUCIBLE NITRIC OXIDE SYNTHASE IN KIDNEY
    BRUCE KONE; Fiscal Year: 2002
    ..the molecular mechanisms underlying the structure, function, and regulation of the inducible nitric oxide synthase (iNOS) genes, and to develop an understanding of their role in renal cell biology...
  69. Antitumor Activity of Inducible Nitric Oxide Synthase
    Keping Xie; Fiscal Year: 2005
    Nitric oxide (NO) is a major cytotoxic molecule, and inducible NO synthase (iNOS) can generate high-output NO...
  70. Ke Jian Liu; Fiscal Year: 2016
    ..In Aim 1 we will investigate the impact of arsenic-mediated iNOS and NADPH oxidase (NOX) induction and subsequent nitric oxide and superoxide generation on the activity of two DNA ..
  71. Evaluating the role of Thrombospondin-1-CD47 mediated nitric oxide signaling in t
    Sarah Amend; Fiscal Year: 2013
    ..Under pathological conditions, NO signaling is upregulated through iNOS. Specific regulatory pathways of iNOS have not been identified...
  72. Andrew J Gow; Fiscal Year: 2016
    ..In inflammation, the most important source of NO is the inducible form of the enzyme iNOS. A key downstream effect of iNOS-derived NO is S-nitrosylation of thiol residues to form S-nitrosothiol (SNO)...
  73. Frank D Gilliland; Fiscal Year: 2016
    ..5 and PM2.5. The results from this program of research will fill crucial gaps in our ability to rapidly identify chronic effects of air pollution in the periodbefore irreversible adverse respiratory effects occur. ..
  74. Kurt Lu; Fiscal Year: 2016
    ..The level of M infiltration and activation using induction of the soluble signaling molecules TNFa and iNOS in pre- and post-BCNU exposed tissue. We will further 2...
  75. Oxidative Stress and Autoimmunity
    M Firoze Khan; Fiscal Year: 2013
    ..Using iNOS inhibitors and iNOS knockout MRL +/+ mice, we will evaluate the potential of RNS in leading to autoimmunity;3) ..
  76. STUDY OF DIABETIC RETINOPATHY
    Timothy S Kern; Fiscal Year: 2013
    ..We have found that the vascular lesions of diabetic retinopathy can be prevented merely by eliminating either iNOS or PARP-1 from the marrow-derived cells only...
  77. Michael D Gunn; Fiscal Year: 2016
    ..of this proposal are that 1) chemical-induced ALI and RADS can be prevented by post-exposure administration of the iNOS inhibitor GW274150;2) chemical-induced AIF can be prevented by inhibiting specific receptor tyrosine kinase ..
  78. PAMELA ANNE MAHER; Fiscal Year: 2014
    ..surface protein tyrosine phosphatase expressed exclusively by cells of hematopoietic lineages and by inhibition of iNOS induction...
  79. WILLIAM NICHOLAS HAINING; Fiscal Year: 2016
    ....
  80. Nitric oxide and cyclooxygenase in arthritis
    Rose Fife; Fiscal Year: 2004
    ..via the activity of one of three forms of nitric oxide synthase (NOS): neuronal NOS (nNOS or NOS 1); inducible NOS (iNOS or NOS 2); and endothelial NOS (eNOS or NOS 3)...
  81. Inhibition of lupus nephritis in IRF-1 deficient mice
    Christopher Reilly; Fiscal Year: 2003
    ..mice overproduce nitric oxide (NO) secondary to increased gene expression of inducible nitric oxide synthase (iNOS). Blockade of iNOS pharmacologically reduces disease expression in MRL/lpr mice...
  82. REGULATION OF MACROPHAGE DEPENDENT ANGIOGENIC ACTIVITY
    SAMUEL LEIBOVICH; Fiscal Year: 2002
    ..VEGF is an important component of MDAA. The bio-activity of VEGF is regulated in macrophages by the iNOS pathway, by hypoxia and by lactate...
  83. REGULATION OF COLITIS BY CYCLOOXYGENASE-2
    Keith Wilson; Fiscal Year: 2001
    ..DESCRIPTION (adapted from the application) Our investigations to date indicate that inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2, enzymes which produce high output nitric oxide and prostanoids, respectively, are ..

Patents1

  1. INDUCIBLE NITRIC OXIDE SYNTHASE AND GENE THEREFOR
    Patent Number: WO9423038-A1; Date:1994-10-13