INMT

Summary

Gene Symbol: INMT
Description: indolethylamine N-methyltransferase
Alias: TEMT, indolethylamine N-methyltransferase, amine N-methyltransferase, aromatic alkylamine N-methyltransferase, arylamine N-methyltransferase, indolamine N-methyltransferase, nicotine N-methyltransferase, thioether S-methyltransferase
Species: human

Top Publications

  1. pmc The Association between the Urinary Excretion of Trimethylselenonium and Trimethylsulfonium in Humans
    Bassam Lajin
    Institute of Chemistry Analytical Chemistry, NAWI Graz, University of Graz, Universitaetsplatz 1, 8010, Graz, Austria
    PLoS ONE 11:e0167013. 2016
  2. pmc Microarray Expression Data Identify DCC as a Candidate Gene for Early Meningioma Progression
    Hans Juergen Schulten
    Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia
    PLoS ONE 11:e0153681. 2016
  3. pmc Read-through transcripts in normal human lung parenchyma are down-regulated in lung adenocarcinoma
    Giulia Pintarelli
    Department of Predictive and Prevention Medicine, Fondazione IRCCS, Istituto Nazionale dei Tumori, Milan, Italy
    Oncotarget 7:27889-98. 2016
  4. doi Selenium metabolism to the trimethylselenonium ion (TMSe) varies markedly because of polymorphisms in the indolethylamine N-methyltransferase gene
    Doris Kuehnelt
    Institute of Chemistry, Analytical Chemistry, NAWI Graz, University of Graz, Graz, Austria
    Am J Clin Nutr 102:1406-15. 2015
  5. doi Potential Association of INMT Nonsynonymous Variant (His46Pro) with Hirschsprung's Disease
    Jason Yongha Kim
    Department of Life Science, Sogang University, Seoul, Republic of Korea
    Neonatology 108:164-71. 2015
  6. pmc Transcriptome analysis in rat kidneys: importance of genes involved in programmed hypertension
    You Lin Tain
    Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan
    Int J Mol Sci 16:4744-58. 2015
  7. doi Comparison of senescence-associated miRNAs in primary skin and lung fibroblasts
    Alice C Holly
    Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, University of Exeter, Barrack Road, Exeter, Devon, EX1 2LU, UK
    Biogerontology 16:423-34. 2015
  8. pmc Noncompetitive inhibition of indolethylamine-N-methyltransferase by N,N-dimethyltryptamine and N,N-dimethylaminopropyltryptamine
    Uyen B Chu
    Department of Neuroscience, University of Wisconsin School of Medicine and Public Health, 1300 University Avenue, Madison, Wisconsin 53706, United States
    Biochemistry 53:2956-65. 2014
  9. doi TCDD dysregulation of 13 AHR-target genes in rat liver
    John D Watson
    Ontario Institute for Cancer Research, Department of Informatics and Bio computing Program, Toronto, Canada Electronic address
    Toxicol Appl Pharmacol 274:445-54. 2014
  10. pmc A genome-wide association study of nephrolithiasis in the Japanese population identifies novel susceptible Loci at 5q35.3, 7p14.3, and 13q14.1
    Yuji Urabe
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    PLoS Genet 8:e1002541. 2012

Scientific Experts

  • You Lin Tain
  • John D Watson
  • Timur A Mavlyutov
  • Y H Kim
  • J Hidalgo
  • Yuji Urabe
  • Hans Juergen Schulten
  • Bassam Lajin
  • Giulia Pintarelli
  • Doris Kuehnelt
  • Jason Yongha Kim
  • Alice C Holly
  • Uyen B Chu
  • Robert Sobkowiak
  • Takahiro Yasui
  • Koichi Matsuda
  • Yusuke Nakamura
  • Michiaki Kubo
  • Kenjiro Kohri
  • Mario Nuño-Ayala
  • S E T Larkin
  • M Piechota
  • Paul C Boutros
  • Hideaki Fujita
  • Eugene P Kopantzev
  • M A Thompson
  • Molly P Kurpius
  • Janne Hukkanen
  • J Kärkkäinen
  • Lorenzo Rosso
  • Luigi Santambrogio
  • Antonella Galvan
  • Rocco Piazza
  • Matteo Incarbone
  • Francesca Colombo
  • Saleh S Baeesa
  • Alessandra Pirola
  • Chiara E Cotroneo
  • Sajjad Karim
  • Fahad Al-Ghamdi
  • Alessandro Palleschi
  • Sara Noci
  • Jaudah Al-Maghrabi
  • Mohammed Al-Qahtani
  • Kevin A Francesconi
  • Mona Al-Sharif
  • Roberta Spinelli
  • Awatif Jamal
  • Adeel Chaudhary
  • Alice Dassano
  • Deema Hussein
  • Mohammed Bangash
  • Tommaso A Dragani
  • Fatima Al-Adwani
  • Jeong Hyun Kim
  • Pieter van de Walle
  • Ayman Alhamdow
  • Helena Skröder
  • Marie Vahter
  • Hyoung Doo Shin
  • Sushma Grellscheid
  • David Dolan
  • Barbro Nermell
  • Kyuwhan Jung
  • Kevin Francesconi
  • Jung Tak Oh
  • Luke C Pilling
  • Jeong Meen Seo
  • Byung Lae Park
  • Karin Broberg
  • Dae Yeon Kim
  • Sabine Kokarnig
  • Kwi Won Park
  • Karin Engström
  • Carina Schlebusch
  • Thomas von Zglinicki
  • Darren J Daniels
  • Luigi Ferrucci
  • Maria Kippler
  • David Melzer
  • Hyun Young Kim
  • Lorna W Harries
  • Kenneth Satyshur
  • Abdol R Hajipour
  • Arnold E Ruoho
  • Sevahn K Vorperian
  • Kelsey Eickstaedt
  • Nicholas V Cozzi
  • Kentaro Mizuno
  • Shoichi Sasaki

Detail Information

Publications30

  1. pmc The Association between the Urinary Excretion of Trimethylselenonium and Trimethylsulfonium in Humans
    Bassam Lajin
    Institute of Chemistry Analytical Chemistry, NAWI Graz, University of Graz, Universitaetsplatz 1, 8010, Graz, Austria
    PLoS ONE 11:e0167013. 2016
    ..In vitro studies showed that the enzyme indole-ethylamine N-methyltransferase (INMT) is responsible for the production of trimethylsulfonium as well as its selenium analogue trimethylselenonium (TMSe)..
  2. pmc Microarray Expression Data Identify DCC as a Candidate Gene for Early Meningioma Progression
    Hans Juergen Schulten
    Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia
    PLoS ONE 11:e0153681. 2016
    ..domain (TM) and cytoplasmic domain, (semaphorin) 6D (SEMA6D), and indolethylamine N-methyltransferase (INMT)...
  3. pmc Read-through transcripts in normal human lung parenchyma are down-regulated in lung adenocarcinoma
    Giulia Pintarelli
    Department of Predictive and Prevention Medicine, Fondazione IRCCS, Istituto Nazionale dei Tumori, Milan, Italy
    Oncotarget 7:27889-98. 2016
    ..Wilcoxon's signed-rank test for paired samples) for eight transcripts: ELAVL1-TIMM44, FAM162B-ZUFSP, IFNAR2-IL10RB, INMT-FAM188B, KIAA1841-C2orf74, NFATC3-PLA2G15, SIRPB1-SIRPD, and SHANK3-ACR...
  4. doi Selenium metabolism to the trimethylselenonium ion (TMSe) varies markedly because of polymorphisms in the indolethylamine N-methyltransferase gene
    Doris Kuehnelt
    Institute of Chemistry, Analytical Chemistry, NAWI Graz, University of Graz, Graz, Austria
    Am J Clin Nutr 102:1406-15. 2015
    ..Selenium is an essential element, but its metabolism in humans is not well characterized. A few small studies indicate that the trimethylselenonium ion (TMSe) is a common selenium metabolite in humans...
  5. doi Potential Association of INMT Nonsynonymous Variant (His46Pro) with Hirschsprung's Disease
    Jason Yongha Kim
    Department of Life Science, Sogang University, Seoul, Republic of Korea
    Neonatology 108:164-71. 2015
    ..Recently, our group has conducted a genome-wide association study in Korean HSCR cases and controls to identify novel markers in other genes...
  6. pmc Transcriptome analysis in rat kidneys: importance of genes involved in programmed hypertension
    You Lin Tain
    Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan
    Int J Mol Sci 16:4744-58. 2015
    ..We observed five shared genes (Bcl6, Dmrtc1c, Egr1, Inmt, and Olr1668) among three different models...
  7. doi Comparison of senescence-associated miRNAs in primary skin and lung fibroblasts
    Alice C Holly
    Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, University of Exeter, Barrack Road, Exeter, Devon, EX1 2LU, UK
    Biogerontology 16:423-34. 2015
    ..02 [skin] and 0.02 [lung] INMT; p = 0.03 [skin] and 0.04 [lung])...
  8. pmc Noncompetitive inhibition of indolethylamine-N-methyltransferase by N,N-dimethyltryptamine and N,N-dimethylaminopropyltryptamine
    Uyen B Chu
    Department of Neuroscience, University of Wisconsin School of Medicine and Public Health, 1300 University Avenue, Madison, Wisconsin 53706, United States
    Biochemistry 53:2956-65. 2014
    Indolethylamine-N-methyltransferase (INMT) is a Class 1 transmethylation enzyme known for its production of N,N-dimethyltryptamine (DMT), a hallucinogen with affinity for various serotonergic, adrenergic, histaminergic, dopaminergic, and ..
  9. doi TCDD dysregulation of 13 AHR-target genes in rat liver
    John D Watson
    Ontario Institute for Cancer Research, Department of Informatics and Bio computing Program, Toronto, Canada Electronic address
    Toxicol Appl Pharmacol 274:445-54. 2014
    ..10-100 fold higher, in at least one strain (Ahrr (L-E), Aldh3a1 (both), Cyp1a2 (both), Cyp1b1 (both), Cyp2a1 (L-E), Inmt (both), Nfe2l2 (L-E), Nqo1 (L-E) and Tiparp (both))...
  10. pmc A genome-wide association study of nephrolithiasis in the Japanese population identifies novel susceptible Loci at 5q35.3, 7p14.3, and 13q14.1
    Yuji Urabe
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    PLoS Genet 8:e1002541. 2012
    ..3 (rs11746443; P = 8.51×10⁻¹², odds ratio (OR) = 1.19), INMT-FAM188B-AQP1 on 7p14.3 (rs1000597; P = 2.16×10⁻¹⁴, OR = 1.22), and DGKH on 13q14...
  11. doi Cystathionine β-synthase deficiency causes infertility by impairing decidualization and gene expression networks in uterus implantation sites
    Mario Nuño-Ayala
    Departamento de Bioquimica y Biologia Molecular y Celular, Facultad de Veterinaria, Instituto de Investigación Sanitaria de Aragón, Universidad de Zaragoza, Zaragoza, Spain
    Physiol Genomics 44:702-16. 2012
    ..We found that changes in expression of Calb1, Ttr, Expi, Inmt, Spink3, Rpgrip1, Krt15, Mt-4, Gzmc, Gzmb, Tdo2, and Afp were important for pregnancy success, since a different ..
  12. pmc Development of the sigma-1 receptor in C-terminals of motoneurons and colocalization with the N,N'-dimethyltryptamine forming enzyme, indole-N-methyl transferase
    T A Mavlyutov
    Department of Neuroscience, University of Wisconsin, School of Medicine and Public Health, 1300 University Ave, Madison, WI 53706, USA
    Neuroscience 206:60-8. 2012
    ..We found that indole-N-methyl transferase (INMT), an enzyme that converts tryptamine into the sigma-1 ligand dimethyltryptamine (DMT), is also localized to ..
  13. ncbi [Absorption, metabolism and excretion of nicotine in humans]
    Robert Sobkowiak
    Zakład Biologii Komórki, Instytut Biologii Eksperymentalnej, Uniwersytet im Adama Mickiewicza, Poznan, Poland
    Postepy Biochem 59:33-44. 2013
    ..The rate of nicotine metabolism is affected by diversified activity of polymorphic enzymes involved in this process, diet, gender and physiological condition of the organism...
  14. doi A replication study for three nephrolithiasis loci at 5q35.3, 7p14.3 and 13q14.1 in the Japanese population
    Takahiro Yasui
    Department of Nephro urology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Hum Genet 58:588-93. 2013
    ..3 (RGS14-SLC34A1-PFN3-F12); rs12669187 and rs1000597 from 7p14.3 (INMT-FAM188B-AQP1); and rs7981733, rs1170155, and rs4142110 from 13q14...
  15. doi Common transcriptional effects in the mouse striatum following chronic treatment with heroin and methamphetamine
    M Piechota
    Department of Molecular Neuropharmacology, Institute of Pharmacology PAS, Smetna 12, Krakow, Poland
    Genes Brain Behav 11:404-14. 2012
    ..enriched in the nucleus accumbens and includes well known (Pdyn, Cartpt and Rgs2) as well as new (Fam40b and Inmt) candidate genes...
  16. ncbi Rates of in vivo methylation of desipramine and nortriptyline
    Molly P Kurpius
    College of Pharmacy, University of Iowa, Iowa City, Iowa 52246, USA
    Pharmacotherapy 26:505-10. 2006
    ..Awareness of the phenomenon could help in discouraging repeated laboratory tests and unnecessary adjustments of drug therapies, resulting in cost savings and better patient outcomes...
  17. ncbi Metabolism and disposition kinetics of nicotine
    Janne Hukkanen
    Division of Clinical Pharmacology and Experimental Therapeutics, Medical Service, San Francisco Genreral Hospital Medical Center, and the Department of Medicine, University of California, San Francisco, Box 1220, San Francisco, CA 94143 1220, USA
    Pharmacol Rev 57:79-115. 2005
    ..Due to the significance of the CYP2A6 enzyme in nicotine clearance, special emphasis is given to the effects and population distributions of CYP2A6 alleles and the regulation of CYP2A6 enzyme...
  18. ncbi Purification and molecular properties of rabbit lung indolamine N-methyltransferase
    G Irace
    Biochemistry 21:1464-70. 1982
    Indolamine N-methyltransferase (INMT) has been purified to an apparent homogeneity from rabbit lung, and some of its catalytic and physicochemical properties have been examined...
  19. ncbi Plasma indolethylamine-n-methyltransferase activity and growth hormone level during sleep: a pilot study
    M Strahilevitz
    Biol Psychiatry 12:171-80. 1977
    ..In the plasma samples from seven of the subjects, indolethylamine-N-methyltransferase (INMT) activity was also determined...
  20. pmc Identification of markers of prostate cancer progression using candidate gene expression
    S E T Larkin
    School of Pharmacy and Biomedical Sciences, University of Portsmouth, St Michaels Building, White Swan Road, Portsmouth, PO1 2DT, UK
    Br J Cancer 106:157-65. 2012
    ..The basis of this variable prognosis is poorly understood, despite considerable research. The aim of this study was to identify markers associated with the progression of PCa...
  21. pmc Metallothioneins and brain injury: What transgenic mice tell us
    Juan Hidalgo
    Neurosciences and Department of Cellular Biology, Physiology and Immunology, Animal Physiology Unit, Faculty of Sciences, Autonomous University of Barcelona, Bellaterra, 08193, Barcelona, Spain
    Environ Health Prev Med 9:87-94. 2004
    ..Results obtained inMT-1&2-null mice and in MT-1-overexpressing mice strongly suggeset that these MT isoforms are important ..
  22. doi Hepatic transcriptomic responses to TCDD in dioxin-sensitive and dioxin-resistant rats during the onset of toxicity
    Paul C Boutros
    Informatics and Bio computing Platform, Ontario Institute for Cancer Research, Toronto, Canada
    Toxicol Appl Pharmacol 251:119-29. 2011
    ..in both strains at all time points tested, including CYP1A1, CYP1A2, CYP1B1, Nqo1, Aldh3a1, Tiparp, Exoc3, and Inmt. Outside this core, the strains differed significantly in the breadth of response: three-fold more genes were ..
  23. doi Rapid decrease in active tension generated by C2C12 myotubes after termination of artificial exercise
    Hideaki Fujita
    Toyota Central R and D Labs Incorporation, Yokomichi, Nagakute, Aichi, 480 1192, Japan
    J Muscle Res Cell Motil 31:279-88. 2010
    ..revealed that the expression of several genes associated with atrophy, namely Smc6, Vegfa, Jarid2, Kitl, Cds2, Inmt, Fasn, Neurl, Topors, and Cul2, were also changed after termination of artificial exercise...
  24. doi Differences in gene expression levels between early and later stages of human lung development are opposite to those between normal lung tissue and non-small lung cell carcinoma
    Eugene P Kopantzev
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16 10 Miklukho Maklaya, Moscow 117997, Russia
    Lung Cancer 62:23-34. 2008
    ..from human fetal and adult lungs revealed 12 differentially transcribed genes: ADH1B, AQP1, FOLR1, SLC34A2, CAV1, INMT, TXNIP, TPM4, ICAM-1, HLA-DRA, EFNA1 and HLA-E...
  25. ncbi Potentially hallucinogenic 5-hydroxytryptamine receptor ligands bufotenine and dimethyltryptamine in blood and tissues
    J Kärkkäinen
    Peijas Hospital, Helsinki University Central Hospital, Vantaa, Finland
    Scand J Clin Lab Invest 65:189-99. 2005
    ..indolethylamines (DMIAs) formed from serotonin and tryptamine by the enzyme indolethylamine N-methyltransferase (INMT) ubiquitously present in non-neural tissues...
  26. ncbi Arylamine N-methyltransferase and thiol methyltransferase activities in cholestatic rat liver induced by common bile duct ligation
    Y H Kim
    Department of Biochemistry, Keimyung University School of Medicine, Taegu, Korea
    Exp Mol Med 33:23-8. 2001
    ..01 and 0.001, respectively). These results suggest that the biosynthesis of arylamine N-methyltransferase and thiol methyltransferase have been induced in response to obstructive jaundice...
  27. ncbi Human indolethylamine N-methyltransferase: cDNA cloning and expression, gene cloning, and chromosomal localization
    M A Thompson
    Department of Pharmacology, Mayo Medical School Mayo Clinic Mayo Foundation, Rochester, Minnesota, 55905, USA
    Genomics 61:285-97. 1999
    Indolethylamine N-methyltransferase (INMT) catalyzes the N-methylation of tryptamine and structurally related compounds...
  28. ncbi Stereospecific N-methylation of the tetrahydroisoquinoline alkaloids isosalsoline and salsolidine by amine N-methyltransferase A from bovine liver
    A H Bahnmaier
    Department of Physiological Chemistry, University of Ulm, Germany
    Chirality 11:160-5. 1999
    ..The results were obtained by using two independent methods, namely a radioassay and HPLC following separate incubation experiments...
  29. ncbi Rabbit lung indolethylamine N-methyltransferase. cDNA and gene cloning and characterization
    M A Thompson
    Department of Pharmacology, Mayo Medical School Mayo Clinic Mayo Foundation, Rochester, Minnesota 55905, USA
    J Biol Chem 273:34502-10. 1998
    Indolethylamine N-methyltransferase (INMT) catalyzes the N-methylation of tryptamine and structurally related compounds...
  30. ncbi Fluorometric assay of rat tissue N-methyltransferases with nicotinamide and four isomeric methylnicotinamides
    A Sano
    Faculty of Pharmaceutical Sciences, Science University of Tokyo, Japan
    Chem Pharm Bull (Tokyo) 40:153-6. 1992
    ..The fluorometric methods used here are also very useful because of their simplicity, sensitivity and selectivity...