ILVBL

Summary

Gene Symbol: ILVBL
Description: ilvB (bacterial acetolactate synthase)-like
Alias: 209L8, AHAS, ILV2H, acetolactate synthase homolog, acetolactate synthase-like protein, ilvB-like protein
Species: human

Top Publications

  1. ncbi Isolation and characterization of subunits of acetohydroxy acid synthase isozyme III and reconstitution of the holoenzyme
    M Vyazmensky
    Department of Life Science, Ben Gurion University of the Negev, Israel
    Biochemistry 35:10339-46. 1996
  2. ncbi Antigen specificity of antihistone antibodies in connective tissue disease patients with anti-U1RNP antibodies
    Takamasa Wayaku
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Rheumatol Int 28:113-9. 2007
  3. ncbi [Construction of a new brewing yeast strain with secretive alpha-amylase activity and reduced diacetyl production]
    Feng Zhang
    Laboratory of Molecular Genetics and Breeding of Yeast, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
    Sheng Wu Gong Cheng Xue Bao 24:837-43. 2008
  4. ncbi The distribution of acetohydroxyacid synthase in soil bacteria
    Darryl R Nelson
    School of Molecular and Microbial Biosciences, University of Sydney, Sydney, NSW, 2006, Australia
    Antonie Van Leeuwenhoek 93:123-32. 2008
  5. pmc Isoleucine synthesis in Corynebacterium glutamicum: molecular analysis of the ilvB-ilvN-ilvC operon
    C Keilhauer
    Institut fur Biotechnologie, Forschungszentrum, Julich, Germany
    J Bacteriol 175:5595-603. 1993
  6. doi Factors enhancing L-valine production by the growth-limited L-isoleucine auxotrophic strain Corynebacterium glutamicum DeltailvA DeltapanB ilvNM13 (pECKAilvBNC)
    Ilze Denina
    Institute of Microbiology and Biotechnology, University of Latvia, Kronvalda boulevard 4, 1586 Riga, Latvia
    J Ind Microbiol Biotechnol 37:689-99. 2010
  7. pmc Common ancestry of Escherichia coli pyruvate oxidase and the acetohydroxy acid synthases of the branched-chain amino acid biosynthetic pathway
    Y Y Chang
    Department of Microbiology, University of Illinois, Urbana 61801
    J Bacteriol 170:3937-45. 1988
  8. ncbi End-product control of enzymes of branched-chain amino acid biosynthesis in Streptomyces coelicolor
    C A Potter
    Department of Genetics, University of Leeds, UK
    Microbiology 142:1945-52. 1996
  9. doi Genetic analysis of pathway regulation for enhancing branched-chain amino acid biosynthesis in plants
    Hao Chen
    Donald Danforth Plant Science Center, St Louis, MO 63132, USA
    Plant J 63:573-83. 2010
  10. ncbi Pharmacology of RALGA, a mixture of retinaldehyde and glycolic acid
    Christian Tran
    Department of Dermatology, University Hospital, Geneva, Switzerland
    Dermatology 210:6-13. 2005

Research Grants

Scientific Experts

Detail Information

Publications113 found, 100 shown here

  1. ncbi Isolation and characterization of subunits of acetohydroxy acid synthase isozyme III and reconstitution of the holoenzyme
    M Vyazmensky
    Department of Life Science, Ben Gurion University of the Negev, Israel
    Biochemistry 35:10339-46. 1996
    The separately cloned large and small subunits of AHAS isozyme III from Escherichia coli have been isolated and purified. The essentially pure small subunit (17 kDa ilvH product) was obtained by a procedure exploiting its low solubility...
  2. ncbi Antigen specificity of antihistone antibodies in connective tissue disease patients with anti-U1RNP antibodies
    Takamasa Wayaku
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Rheumatol Int 28:113-9. 2007
    ..However, both IgG and IgM AHAs against outer portion of chromatin (H1, H2A, or H2B) were generally higher in SLE compared with other diseases...
  3. ncbi [Construction of a new brewing yeast strain with secretive alpha-amylase activity and reduced diacetyl production]
    Feng Zhang
    Laboratory of Molecular Genetics and Breeding of Yeast, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
    Sheng Wu Gong Cheng Xue Bao 24:837-43. 2008
    ..was inserted in the ILV2 locus of industrial brewer's yeast strain YSF-5 encoding alpha-acetolactate synthase (AHAS) by homologous recombination...
  4. ncbi The distribution of acetohydroxyacid synthase in soil bacteria
    Darryl R Nelson
    School of Molecular and Microbial Biosciences, University of Sydney, Sydney, NSW, 2006, Australia
    Antonie Van Leeuwenhoek 93:123-32. 2008
    ..synthase, allowing the bacteria to grow in the presence of valine (which causes feedback inhibition of AHAS I) or the sulfonylurea herbicide triasulfuron (which inhibits AHAS II) although a slight lag phase was observed in ..
  5. pmc Isoleucine synthesis in Corynebacterium glutamicum: molecular analysis of the ilvB-ilvN-ilvC operon
    C Keilhauer
    Institut fur Biotechnologie, Forschungszentrum, Julich, Germany
    J Bacteriol 175:5595-603. 1993
    Acetohydroxy acid synthase (AHAS) and isomeroreductase (IR) catalyze subsequent reactions in the flux of metabolites towards isoleucine, valine, leucine, and pantothenate...
  6. doi Factors enhancing L-valine production by the growth-limited L-isoleucine auxotrophic strain Corynebacterium glutamicum DeltailvA DeltapanB ilvNM13 (pECKAilvBNC)
    Ilze Denina
    Institute of Microbiology and Biotechnology, University of Latvia, Kronvalda boulevard 4, 1586 Riga, Latvia
    J Ind Microbiol Biotechnol 37:689-99. 2010
    ..A sharp increase in acetohydroxy acid synthase (AHAS) activity, a slight increase in acetohydroxyacid isomeroreductase (AHAIR) activity, and a dramatic increase in L: -..
  7. pmc Common ancestry of Escherichia coli pyruvate oxidase and the acetohydroxy acid synthases of the branched-chain amino acid biosynthetic pathway
    Y Y Chang
    Department of Microbiology, University of Illinois, Urbana 61801
    J Bacteriol 170:3937-45. 1988
    ..The best studied of these enigmatic nonredox flavoproteins are the acetohydroxy acid synthases (AHAS), which catalyze early steps in the synthesis of branched-chain amino acids in bacteria, yeasts, and plants...
  8. ncbi End-product control of enzymes of branched-chain amino acid biosynthesis in Streptomyces coelicolor
    C A Potter
    Department of Genetics, University of Leeds, UK
    Microbiology 142:1945-52. 1996
    ..on end-product control in the model organism Streptomyces coelicolor of the enzymes acetohydroxy acid synthase (AHAS) and isopropylmalate synthase (IPMS), mediating steps in the pathways to isoleucine-valine and leucine respectively...
  9. doi Genetic analysis of pathway regulation for enhancing branched-chain amino acid biosynthesis in plants
    Hao Chen
    Donald Danforth Plant Science Center, St Louis, MO 63132, USA
    Plant J 63:573-83. 2010
    ..Map-based cloning revealed that VAT1 encodes a regulatory subunit of acetohydroxy acid synthase (AHAS), the first committed enzyme in the BCAA biosynthesis pathway...
  10. ncbi Pharmacology of RALGA, a mixture of retinaldehyde and glycolic acid
    Christian Tran
    Department of Dermatology, University Hospital, Geneva, Switzerland
    Dermatology 210:6-13. 2005
    Retinoids and alpha-hydroxy acids (AHAs) are major compounds in topical therapy. They exert distinct but potentially complementary activities. However, their association is limited by their respective irritating potential...
  11. ncbi Acetohydroxy acid synthase and threonine deaminase activities, and the biosynthesis of isoleucine-leucine-valine in Streptococcus bovis
    A L Basso
    Istituto Adattamento Bovini e Bufali Ambiente Mezzogiorno, C N R, Naples, Italy
    Res Microbiol 144:539-45. 1993
    Acetohydroxy acid synthase (AHAS) and threonine deaminase (TD) activities were found in Streptococcus bovis and shown to be involved in the biosynthesis of the branched chain amino acids isoleucine, leucine and valine...
  12. doi Valine 375 and phenylalanine 109 confer affinity and specificity for pyruvate as donor substrate in acetohydroxy acid synthase isozyme II from Escherichia coli
    Andrea Steinmetz
    Albrecht von Haller Institute and Göttingen Centre for Molecular Biosciences, Ernst Caspari Haus, Department of Bioanalytics, Georg August University Gottingen, Justus von Liebig Weg 11, Germany
    Biochemistry 49:5188-99. 2010
    Acetohydroxy acid synthase (AHAS) is a thiamin diphosphate-dependent enzyme that catalyzes the condensation of pyruvate with either another pyruvate molecule (product acetolactate) or 2-ketobutyrate (product acetohydroxybutyrate) as the ..
  13. doi Interactions between large and small subunits of different acetohydroxyacid synthase isozymes of Escherichia coli
    Maria Vyazmensky
    Department of Life Sciences, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Biochemistry 48:8731-7. 2009
    ..subunits (LSUs; ilvB, ilvG and ilvI, respectively) of enterobacterial acetohydroxyacid synthases isozymes (AHAS I, II and III) have molecular weights approximately 60 kDa and are paralogous with a family of other thiamin ..
  14. ncbi Comparative genotoxicity evaluation of imidazolinone herbicides in somatic cells of Drosophila melanogaster
    Edson José Fragiorge
    Universidade Federal de Uberlandia, Instituto de Genética e Bioquímica, Laboratório de Mutagênese, Av Para 1720, Campus Umuarama, 38400 902 Uberlândia, MG, Brazil
    Food Chem Toxicol 46:393-401. 2008
    ..are classified as imidazolinone (IMI) herbicides and their mode of action is to inhibit acetohydroxyacid synthase (AHAS), an enzyme involved in the biosynthesis of the amino acids leucine, isoleucine and valine...
  15. doi Antiproliferative effects of lactic acid via the induction of apoptosis and cell cycle arrest in a human keratinocyte cell line (HaCaT)
    Yu Ping Hsiao
    Department of Dermatology, Chung Shan Medical University Hospital, Taichung, Taiwan, ROC
    J Dermatol Sci 54:175-84. 2009
    Alpha-hydroxy acids (AHAs) have been widely used in cosmetic industry. However, knowledge on cytotoxicity of AHAs in human keratinocytes is limited.
  16. ncbi Cloning and sequence determination of the acetohydroxy acid synthase genes from Brevibacterium flavum MJ233 by using the polymerase chain reaction
    M Inui
    Tsukuba Research Center, Mitsubishi Petrochemical Co, Ltd, Ibaraki, Japan
    DNA Seq 3:303-10. 1993
    Taking advantage of highly conserved domains present in the three acetohydroxy acid synthase (AHAS) isozymes from E. coli K-12, we designed degenerate oligonucleotides corresponding to these regions...
  17. doi Anti-hypothalamus and anti-pituitary antibodies may contribute to perpetuate the hypopituitarism in patients with Sheehan's syndrome
    Annamaria De Bellis
    Department of Clinical and Experimental Medicine and Surgery F Magrassi, A Lanzara, Second University of Naples, via Pansini N 5, 80131 Napoli, Italy
    Eur J Endocrinol 158:147-52. 2008
    ..detected in some patients with Sheehan's syndrome (SS) suggesting an autoimmune pituitary involvement in the development of their hypopituitarism, hypothalamic cell anti-hypothalamus antibodies (AHAs) have not been investigated so far.
  18. ncbi Herbicidal inhibitors of amino acid biosynthesis and herbicide-tolerant crops
    S Tan
    BASF Corporation, Research Triangle Park, North Carolina 27709, USA
    Amino Acids 30:195-204. 2006
    Acetohydroxyacid synthase (AHAS) inhibitors interfere with branched-chain amino acid biosynthesis by inhibiting AHAS. Glyphosate affects aromatic amino acid biosynthesis by inhibiting 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS)...
  19. doi Docking and 3D-QSAR studies of acetohydroxy acid synthase inhibitor sulfonylurea derivatives
    Kunal Roy
    Drug Theoretics and Cheminformatics Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, 700032, India
    J Mol Model 16:951-64. 2010
    ..quantitative-structure activity relationship (3D-QSAR) studies were performed on acetohydroxy acid synthase (AHAS) inhibitor sulfonylurea analogues with potential herbicidal activity...
  20. ncbi Expression, purification, characterization, and reconstitution of the large and small subunits of yeast acetohydroxyacid synthase
    S S Pang
    Centre for Protein Structure, Function and Engineering, Department of Biochemistry, The University of Queensland, Brisbane, Australia
    Biochemistry 38:5222-31. 1999
    Acetohydroxyacid synthase (AHAS, EC 4.1.3.18) catalyzes the first step in the biosynthesis of the branched-chain amino acids...
  21. doi Crystal structures of two novel sulfonylurea herbicides in complex with Arabidopsis thaliana acetohydroxyacid synthase
    Jian guo Wang
    State Key Laboratory of Elemento organic Chemistry, National Pesticide Engineering Research Center, Nankai University, Tianjin, China
    FEBS J 276:1282-90. 2009
    Acetohydroxyacid synthase (AHAS; EC 2.2.1.6) is the first enzyme in the biosynthetic pathway of the branched-chain amino acids...
  22. doi Hydroxycarbonyl anion (m/z 45), a diagnostic marker for alpha-hydroxy carboxylic acids
    Jason B Bialecki
    Center for Mass Spectrometry, Department of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, New Jersey 07030, USA
    J Mass Spectrom 44:252-9. 2009
    Collision-induced dissociation mass spectra of anions derived from alpha-hydroxy carboxylic acids (AHAs) show a diagnostic peak at m/z 45...
  23. doi Molecular and biochemical characterization of an induced mutation conferring imidazolinone resistance in sunflower
    Carlos A Sala
    Biotechnology Department, NIDERA S A, Ruta 8 km 376, Casilla de Correo 6, 2600, Venado Tuerto, Santa Fe, Argentina
    Theor Appl Genet 118:105-12. 2008
    ..This pattern was in close association with the AHAS-inhibition kinetics of protein extracts of CLHA-Plus challenged with different doses of imazamox and chlorsulfuron...
  24. doi Deregulation of acetohydroxy-acid synthase: Loss of allosteric inhibition conferred by mutations in the catalytic subunit
    J Kopecky
    Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Folia Microbiol (Praha) 53:467-71. 2008
    Acetohydroxy-acid synthases (AHAS) of two mutant strains Streptomyces cinnamonensis ACB-NLR-2 and BVR-18 were chosen for this study for their apparent activation by valine, which regularly acts as an allosteric inhibitor...
  25. doi Production of 2-methyl-1-butanol in engineered Escherichia coli
    Anthony F Cann
    Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA 90095, USA
    Appl Microbiol Biotechnol 81:89-98. 2008
    ..we explored the biodiversity of enzymes catalyzing key parts of the isoleucine biosynthetic pathway, finding that AHAS II (ilvGM) from Salmonella typhimurium and threonine deaminase (ilvA) from Corynebacterium glutamicum improve 2MB ..
  26. pmc Crystal structures of TM0549 and NE1324--two orthologs of E. coli AHAS isozyme III small regulatory subunit
    Janusz J Petkowski
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville 22908, USA
    Protein Sci 16:1360-7. 2007
    Crystal structures of two orthologs of the regulatory subunit of acetohydroxyacid synthase III (AHAS, EC 2.2.1...
  27. ncbi Does lactobionic acid affect the colloidal structure and skin moisturizing potential of the alkyl polyglucoside-based emulsion systems?
    M Z Tasic-Kostov
    Department of Pharmacy, Faculty of Medicine, University of Nis, Serbia
    Pharmazie 66:862-70. 2011
    ..APG)-based emulsion as vehicle for lactobionic acid (LA), advantageous representative of the alphahydroxyacids (AHAs)-multifunctional moisturizers, assessing the safety for use (in vitro acute skin irritation test using cytotoxicity ..
  28. ncbi Acetohydroxyacid synthase: a new enzyme for chiral synthesis of R-phenylacetylcarbinol
    Stanislav Engel
    Department of Biotechnology Engineering, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Biotechnol Bioeng 83:833-40. 2003
    We have found that acetohydroxyacid synthase (AHAS) is an efficient catalyst for the enantiospecific (> or =98% enantiomeric excess) synthesis of (R)-phenylacetylcarbinol (R-PAC) from pyruvate and benzaldehyde, despite the fact that ..
  29. doi Biochemical characterization and evaluation of potent inhibitors of the Pseudomonas aeruginosa PA01 acetohydroxyacid synthase
    June Haeng Cho
    Department of Chemistry, Institute of Natural Science, Hanyang University, Seoul 133 791, Republic of Korea
    Biochimie 95:1411-21. 2013
    ..isoleucine via a common biosynthetic pathway in which the first reaction is catalyzed by acetohydroxyacid synthase (AHAS, EC 4.1.3.18). Recently, AHAS was identified as a potential anti bacterial target...
  30. ncbi Characterization of acetohydroxyacid synthase from Mycobacterium tuberculosis and the identification of its new inhibitor from the screening of a chemical library
    Kyoung Jae Choi
    Department of Chemistry, Hanyang University, Seoul 133 791, Korea
    FEBS Lett 579:4903-10. 2005
    Acetohydroxyacid synthase (AHAS) is a thiamin diphosphate- (ThDP-) and FAD-dependent enzyme that catalyzes the first common step in the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine...
  31. doi Impact of the ahas transgene and of herbicides associated with the soybean crop on soil microbial communities
    Rosinei Aparecida Souza
    Embrapa Soja, Caixa Postal 231, Londrina, Parana, 86001 970, Brazil
    Transgenic Res 22:877-92. 2013
    ..The aim of this study was to evaluate the effects of transgenic soybean containing the ahas gene conferring resistance to herbicides of the imidazolinone group, and of the herbicides associated with ..
  32. ncbi The active site and mechanism of action of recombinant acetohydroxy acid synthase from tobacco
    Moon Young Yoon
    Department of Chemistry, Hanyang University, Seoul 133 791, South Korea
    FEBS Lett 555:185-91. 2003
    Acetohydroxy acid synthase (AHAS) is one of several enzymes that require thiamine diphosphate and a divalent cation as essential cofactors. Recently, the three-dimensional structure of the enzyme from yeast has been determined [Pang et al...
  33. ncbi Column flow reactor using acetohydroxyacid synthase I from Escherichia coli as catalyst in continuous synthesis of R-phenylacetyl carbinol
    Stanislav Engel
    Department of Biotechnology Engineering, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Biotechnol Bioeng 89:733-40. 2005
    We tested the possibility of utilizing acetohydroxyacid synthase I (AHAS I) from Escherichia coli in a continuous flow reactor for production of R-phenylacetyl carbinol (R-PAC)...
  34. ncbi Roles of three well-conserved arginine residues in mediating the catalytic activity of tobacco acetohydroxy acid synthase
    Dung Tien Le
    School of Life Sciences, Chungbuk National University, Cheongju 361 763, Korea
    J Biochem 138:35-40. 2005
    Acetohydroxy acid synthase (AHAS, EC 2.2.1.6; also known as acetolactate synthase, ALS) catalyzes the first common step in the biosynthesis of valine, leucine, and isoleucine in plants and microorganisms...
  35. pmc Targeting of the virulence factor acetohydroxyacid synthase by sulfonylureas results in inhibition of intramacrophagic multiplication of Brucella suis
    Rose Anne Boigegrain
    INSERM U 431, Universite Montpellier II, CC 100, Place E Bataillon, F 34095 Montpellier, France
    Antimicrob Agents Chemother 49:3922-5. 2005
    The acetohydroxyacid synthase (AHAS) of Brucella suis can be effectively targeted by the sulfonylureas chlorimuron ethyl and metsulfuron methyl...
  36. doi In vitro and ex vivo activity of new derivatives of acetohydroxyacid synthase inhibitors against Mycobacterium tuberculosis and non-tuberculous mycobacteria
    Hosung Sohn
    Department of Microbiology, College of Medicine, Chungnam National University, 6 Munhwa dong, Jung ku, Daejeon 301 747, South Korea
    Int J Antimicrob Agents 31:567-71. 2008
    Sulfometuron methyl (SM) is an inhibitor of acetohydroxyacid synthase (AHAS), the first common enzyme in the branched-chain amino acid biosynthetic pathway, and shows activity against Mycobacterium tuberculosis both in vitro and in vivo...
  37. doi Rural speech-language pathologists' perceptions of working with allied health assistants
    Rachael O'Brien
    The University of Newcastle, Newcastle, Australia
    Int J Speech Lang Pathol 15:613-22. 2013
    ..address the problem of workforce shortages and growing clinical demand by employing allied health assistants (AHAs) to provide clinical and administrative support to AH professionals...
  38. doi Bacterial acetohydroxyacid synthase and its inhibitors--a summary of their structure, biological activity and current status
    Vinayakumar Gedi
    Department of Chemistry, Institute of Natural Sciences, Hanyang University, Seoul, Korea
    FEBS J 279:946-63. 2012
    Acetohydroxyacid synthase (anabolic AHAS; EC 2.2.1.6) is a thiamin diphosphate-dependent enzyme that catalyzes the first step in the branched-chain amino acid (BCAA) biosynthesis pathway...
  39. doi Molecular characterization of Als1, an acetohydroxyacid synthase mutation conferring resistance to sulfonylurea herbicides in soybean
    Cecilia Ghio
    Soybean Breeding Program, NIDERA S A, Tucuman, Argentina
    Theor Appl Genet 126:2957-68. 2013
    The AHAS gene family in soybean was characterized. The locus Als1 for sulfonylurea resistance was mapped and the resistant allele was characterized at the molecular level...
  40. pmc Stable chloroplast transformation of the unicellular red alga Porphyridium species
    Miri Lapidot
    Department of Life Sciences, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Plant Physiol 129:7-12. 2002
    ..system for Rhodophytes and is based on use of a mutant form of the gene encoding acetohydroxyacid synthase [AHAS(W492S)] as a dominant selectable marker...
  41. ncbi Crystallization of the FAD-independent acetolactate synthase of Klebsiella pneumoniae
    S S Pang
    Centre for Protein Structure, Function and Engineering, Department of Biochemistry and Molecular Biology, School of Molecular and Microbial Sciences The University of Queensland, Brisbane QLD 4072, Australia
    Acta Crystallogr D Biol Crystallogr 58:1237-9. 2002
    ..The enzyme (EC 4.1.3.18) that forms 2-acetolactate is known as either acetohydroxyacid synthase (AHAS) or acetolactate synthase (ALS), with the latter name preferred for the catabolic enzyme...
  42. ncbi Determination of alpha hydroxy acids in fruits by capillary electrophoresis
    Suwanna Vorarat
    Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, 40002, Thailand
    Anal Sci 18:893-6. 2002
    ..5 and 5 micrograms ml-1 for citric acid and malic acid, respectively. AHAs from natural fruit juices (orange and grape) were determined and measured with this method.
  43. pmc Global expression profiling and physiological characterization of Corynebacterium glutamicum grown in the presence of L-valine
    C Lange
    Institut für Biotechnologie 1, Forschungszentrum Julich, D 52425 Julich, Germany
    Appl Environ Microbiol 69:2521-32. 2003
    ..e., the large subunit of acetohydroxyacid synthase (AHAS), and by an increased AHAS activity of valine-treated VAL1 cells...
  44. ncbi Systemic and topical drugs for aging skin
    Michael Kockaert
    Albert Schweitzer Hospital, Department of Dermatology, P O Box 306, 3300 AH Dordrecht, The Netherlands
    J Drugs Dermatol 2:435-41. 2003
    ..The most frequently used topical drugs include retinoids, alpha hydroxy acids (AHAs), vitamin C, beta hydroxy acids, anti-oxidants, and tocopherol...
  45. pmc Intracellular proton-mediated activation of TRPV3 channels accounts for the exfoliation effect of α-hydroxyl acids on keratinocytes
    Xu Cao
    Department of Neurobiology, Neuroscience Research Institute, Peking University Health Science Center, China
    J Biol Chem 287:25905-16. 2012
    Hydroxyl acids (AHAs) from natural sources act as proton donors and topical compounds that penetrate skin and are well known in the cosmetic industry for their use in chemical peels and improvement of the skin...
  46. doi Evaluation of the in vitro and intracellular efficacy of new monosubstituted sulfonylureas against extensively drug-resistant tuberculosis
    Di Wang
    Department of Clinical Laboratory, The 309th Hospital of Chinese People s Liberation Army, Beijing 100091, China
    Int J Antimicrob Agents 40:463-6. 2012
    Acetohydroxyacid synthase (AHAS) has been regarded as a potential drug target against Mycobacterium tuberculosis as it catalyses the first step in the pathway for biosynthesis of branched-chain amino acids...
  47. ncbi [Production of transgenic pea (Pisum sativum L.) plants resistant to the herbicide pursuit]
    S N Nifantova
    Tsitol Genet 39:16-21. 2005
    Transgenic pea (Pisum sativum L.) plants containing mutant ahas/als gene were obtained using Agrobacterium-mediated genetic transformation...
  48. doi Sulfonylureas have antifungal activity and are potent inhibitors of Candida albicans acetohydroxyacid synthase
    Yu Ting Lee
    School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane 4072, Queensland, Australia
    J Med Chem 56:210-9. 2013
    The sulfonylurea herbicides exert their activity by inhibiting plant acetohydroxyacid synthase (AHAS), the first enzyme in the branched-chain amino acid biosynthesis pathway...
  49. ncbi A polyhydroxy acid skin care regimen provides antiaging effects comparable to an alpha-hydroxyacid regimen
    Brenda L Edison
    NeoStrata Company, Inc, Princeton, New Jersey, USA
    Cutis 73:14-7. 2004
    ..significant evidence that PHAs provide antiaging effects to skin, a direct comparison between alpha-hydroxyacids (AHAs) and PHAs for these effects has not been conducted...
  50. ncbi At the root of its success. AHAs lobbying muscle comes from strong network of local advocates
    Michael Heaney
    University of Chicago, USA
    Mod Healthc 34:23. 2004
  51. pmc Acetohydroxy acid synthase I, a required enzyme for isoleucine and valine biosynthesis in Escherichia coli K-12 during growth on acetate as the sole carbon source
    F E Dailey
    J Bacteriol 165:453-60. 1986
    Escherichia coli K-12 has two acetohydroxy acid synthase (AHAS) isozymes (AHAS I and AHAS III)...
  52. ncbi Characterisation of the enzyme activities involved in the valine biosynthetic pathway in a valine-producing strain of Corynebacterium glutamicum
    D Leyval
    Laboratoire Bioprocédés Agro Alimentaires, ENSAIA, Institut National Polytechnique de Lorraine 2, avenue de la Forêt de Haye, BP 172, F 54505 Vandoeuvre les Nancy cedex, France
    J Biotechnol 104:241-52. 2003
    ..In this micro-organism, this pathway might involve up to five enzyme activities: acetohydroxy acid synthase (AHAS), acetohydroxy acid isomeroreductase (AHAIR), dihydroxyacid dehydratase and transaminases B and C...
  53. doi Computational study on the carboligation reaction of acetohidroxyacid synthase: new approach on the role of the HEThDP- intermediate
    Gonzalo Jaña
    Grupo de Quimica Teorica y Computacional, Facultad de Ciencias Quimicas, Universidad de Concepcion, Casilla 160 C, Concepcion, Chile
    Proteins 78:1774-88. 2010
    Acetohydroxyacid synthase (AHAS) is a thiamin diphosphate dependent enzyme that catalyses the decarboxylation of pyruvate to yield the hydroxyethyl-thiamin diphosphate (ThDP) anion/enamine intermediate (HEThDP(-))...
  54. doi Investigation of antihypothalamus and antipituitary antibodies in amateur boxers: is chronic repetitive head trauma-induced pituitary dysfunction associated with autoimmunity?
    Fatih Tanriverdi
    Department of Endocrinology, Erciyes University Medical School, Kayseri, Turkey
    Eur J Endocrinol 162:861-7. 2010
    ..whether autoimmune mechanisms could play a role in the pituitary dysfunction due to sports-related head trauma, we investigated the presence of antipituitary antibodies (APAs) and antihypothalamus antibodies (AHAs) in amateur boxers.
  55. doi Evaluation of substituted triazol-1-yl-pyrimidines as inhibitors of Bacillus anthracis acetohydroxyacid synthase
    Vinayakumar Gedi
    Department of Chemistry and Institute of Natural Sciences, Hanyang University, Seoul 133 791, Republic of Korea
    Biochim Biophys Acta 1804:1369-75. 2010
    Acetohydroxyacid synthase (AHAS), a potential target for antimicrobial agents, catalyzes the first common step in the biosynthesis of the branched-chain amino acids...
  56. pmc Branched-chain amino acids are required for the survival and virulence of Actinobacillus pleuropneumoniae in swine
    Sargurunathan Subashchandrabose
    Comparative Medicine and Integrative Biology Program, Department of Microbiology and Molecular Genetics, 5193 BPS Building, Michigan State University, East Lansing, MI 48824, USA
    Infect Immun 77:4925-33. 2009
    ..ilvI was identified as an in vivo-induced (ivi) gene and encodes the enzyme acetohydroxyacid synthase (AHAS) required for branched-chain amino acid (BCAA) biosynthesis...
  57. pmc Mechanism of de novo branched-chain amino acid synthesis as an alternative electron sink in hypoxic Aspergillus nidulans cells
    Motoyuki Shimizu
    Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8572, Japan
    Appl Environ Microbiol 76:1507-15. 2010
    ..A knockout strain of the gene encoding the large subunit of acetohydroxy acid synthase (AHAS), which catalyzes the initial reaction of the synthesis, required branched-chain amino acids for growth and ..
  58. ncbi Construction of amylolytic industrial brewing yeast strain with high glutathione content for manufacturing beer with improved anti-staling capability and flavor
    Jinjing Wang
    The Laboratory of Molecular Genetics and Breeding of Yeasts, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, P R China, BBEL, Washington State University, Pullman, WA 99163, U S A
    J Microbiol Biotechnol 20:1539-45. 2010
    ..alpha-amylase were co-expressed in industrial brewing yeast strain Y31 targeting at alpha-acetolactate synthase (AHAS) gene (ILV2) and alcohol dehydrogenase gene (ADH2), and new recombinant strain TY3 was constructed...
  59. doi Structural and functional evaluation of three well-conserved serine residues in tobacco acetohydroxyacid synthase
    Moon Young Yoon
    Department of Chemistry, Hanyang University, Seoul, Republic of Korea
    Biochimie 92:65-70. 2010
    ..pathway for the biosynthesis of branched-chain amino acids (BCAAs) is catalyzed by acetohydroxyacid synthase (AHAS)...
  60. doi Chemical synthesis, in vitro acetohydroxyacid synthase (AHAS) inhibition, herbicidal activity, and computational studies of isatin derivatives
    Jianguo Wang
    State Key Laboratory and Institute of Elemento Organic Chemistry, Nankai University, Tianjin 300071, China
    J Agric Food Chem 59:9892-900. 2011
    Acetohydroxyacid synthase (AHAS) catalyzes the first common step in the biosynthesis of the branched-chain amino acids. As a result of its metabolic importance in plants, it is a target for many commercial herbicides...
  61. doi A minimal DNA cassette as a vector for genetic transformation of soybean (Glycine max)
    G R Vianna
    EMBRAPA Recursos Geneticos e Biotecnologia, Laboratório de Transferência e Expressão de Genes, Parque Estação Biológica, Brasilia, DF, Brasil
    Genet Mol Res 10:382-90. 2011
    ..Vector pAC321 was digested with the restriction enzyme PvuII to produce the 6159 bp ahas fragment, which contains the mutated ahas gene from Arabidopsis thaliana (Brassicaceae), under the control of its ..
  62. doi Identification and characterization of inhibitors of Haemophilus influenzae acetohydroxyacid synthase
    Vinayakumar Gedi
    Department of Chemistry and Research Institute of Natural Sciences, Hanyang University, Seoul 133 791, South Korea
    Enzyme Microb Technol 49:1-5. 2011
    Acetohydroxyacid synthase (AHAS), a potential target for antimicrobial agents, catalyzes the first common step in the biosynthesis of branched-chain amino acids...
  63. doi A treatment strategy implementing combination therapy with sitagliptin and metformin results in superior glycaemic control versus metformin monotherapy due to a low rate of addition of antihyperglycaemic agents
    L Olansky
    Department of Endocrinology, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Diabetes Obes Metab 13:841-9. 2011
    ..fixed-dose combination (FDC) and initial metformin monotherapy, with the option to add additional antihyperglycaemic agents (AHAs) in either treatment arm during the second phase of the study in order to reach adequate glycaemic control.
  64. ncbi Characterization of acetohydroxyacid synthase I from Escherichia coli K-12 and identification of its inhibitors
    Ngoc Chien Pham
    Department of Chemistry, Hanyang University, Seoul, Korea
    Biosci Biotechnol Biochem 74:2281-6. 2010
    ..Escherichia coli contains three active isoenzymes, and acetohydroxyacid synthase I (AHAS I) large subunit is encoded by the ilvB gene. In this study, the ilvB gene from E...
  65. pmc Single nucleotide mutation in the barley acetohydroxy acid synthase (AHAS) gene confers resistance to imidazolinone herbicides
    Hyejin Lee
    Department of Crop and Soil Sciences, Washington State University, Pullman, WA 99164, USA
    Proc Natl Acad Sci U S A 108:8909-13. 2011
    ..M(2)/M(3) population of barley cultivar Bob was screened for resistance against acetohydroxy acid synthase (AHAS)-inhibiting herbicides...
  66. pmc Metabolic engineering of Corynebacterium glutamicum for 2-ketoisovalerate production
    Felix S Krause
    Institute of Microbiology and Biotechnology, University of Ulm, 89069 Ulm, Germany
    Appl Environ Microbiol 76:8053-61. 2010
    ..overexpression of the ilvBNCD genes, encoding the l-valine biosynthetic enzymes acetohydroxyacid synthase (AHAS), acetohydroxyacid isomeroreductase, and dihydroxyacid dehydratase...
  67. doi Direct analysis of oligosaccharides and alpha hydroxy acids in fruits using electrosonic spray ionization mass spectrometry
    Rui Chen
    Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China
    Analyst 136:3809-14. 2011
    ..In this study, we applied ESSI MS to direct analysis of oligosaccharides and alpha hydroxy acids (AHAs) in fruits...
  68. ncbi Biosynthesis of 2-aceto-2-hydroxy acids: acetolactate synthases and acetohydroxyacid synthases
    D Chipman
    Department of Life Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Biochim Biophys Acta 1385:401-19. 1998
    ..from pyruvate and 2-oxobutyrate, as well as of acetolactate from two molecules of pyruvate (the ALS/AHAS group)...
  69. doi Amino acids conferring herbicide resistance in tobacco acetohydroxyacid synthase
    Dung Tien Le
    Research Team for Vector Borne Diseases, National Agriculture Research Center Kannond, Tsukuba, Ibaraki, Japan
    GM Crops 1:62-7. 2010
    Acetohydroxyacid synthase (AHAS) (EC 4.1.3.18) is a target of commercially available herbicides such as sulfonylurea, imidazolinone, and triazolopyrimidine...
  70. doi Syntheses and herbicidal activity of new triazolopyrimidine-2-sulfonamides as acetohydroxyacid synthase inhibitor
    Chao Nan Chen
    Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, PR China
    Bioorg Med Chem 18:4897-904. 2010
    ..from preparing bioisosteres of the sulfonylurea herbicides, is an important class of acetohydroxyacid synthase (AHAS, EC 4.1.3.18) inhibitors...
  71. doi Response to imazapyr and dominance relationships of two imidazolinone-tolerant alleles at the Ahasl1 locus of sunflower
    Carlos A Sala
    Departamento de Biotecnologia, NIDERA S A, Casilla de Correo 6, CP 2600, Venado Tuerto, Santa Fe, Argentina
    Theor Appl Genet 124:385-96. 2012
    ..5 times higher than homozygous Imisun materials (Ahasl1-1/Ahasl1-1). In vitro AHAS enzyme activity assays using increasing doses of herbicide (from 0 to 100 μM) showed similar trends, where ..
  72. ncbi Lipid A receptor TLR4-mediated signaling pathways
    Masahiro Yamamoto
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
    Adv Exp Med Biol 667:59-68. 2009
    ..In recent years, Lipid Ahas also been recognized by a Toll-like receptor, TLR4...
  73. doi 1H, 13C, 15N assignments of the dimeric regulatory subunit (ilvN) of the E. coli AHAS I
    N Megha Karanth
    Lab No 207, Molecular Biophysics Unit, Indian Institute of Science, Bangalore, 560012, India
    Biomol NMR Assign 4:131-3. 2010
    Acetohydroxyacid synthase (AHAS) is an enzyme involved in the biosynthesis of the branched chain amino acids viz, valine, leucine and isoleucine...
  74. pmc Cyclohexane-1,2-dione hydrolase from denitrifying Azoarcus sp. strain 22Lin, a novel member of the thiamine diphosphate enzyme family
    Alma K Steinbach
    Fachbereich Biologie, Universitaet Konstanz, Universitaetsstrasse 10, 78457 Constance, Germany
    J Bacteriol 193:6760-9. 2011
    ..The enzymes acetohydroxyacid synthase (AHAS) from Saccharomyces cerevisiae, pyruvate oxidase (POX) from Lactobacillus plantarum, benzoylformate decarboxylase ..
  75. doi Cloning, characterization and evaluation of potent inhibitors of Shigella sonnei acetohydroxyacid synthase catalytic subunit
    Won Mook Lim
    Department of Chemistry, Hanyang University, Seoul, South Korea
    Biochim Biophys Acta 1814:1825-31. 2011
    Acetohydroxyacid synthase (AHAS) is a thiamin diphosphate (ThDP)- and flavin adenine dinucleotide (FAD)-dependent plant and microbial enzyme that catalyzes the first common step in the biosynthesis of essential amino acids such as leucine,..
  76. doi Lactobionic acid in a natural alkylpolyglucoside-based vehicle: assessing safety and efficacy aspects in comparison to glycolic acid
    Marija Tasic-Kostov
    Department of Pharmacy, School of Medicine, University of Nis, Nis, Serbia
    J Cosmet Dermatol 9:3-10. 2010
    Lactobionic acid (LA) is a newer cosmeceutical active belonging to the class of alpha-hydroxyacids (AHAs), showing advantages over them. The aim of part I of this study was to compare efficacy and irritation potential of LA vs...
  77. doi Computational determination of fundamental pathway and activation barriers for acetohydroxyacid synthase-catalyzed condensation reactions of alpha-keto acids
    Ying Xiong
    Key Laboratory of Pesticide and Chemical Biology of the Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, People s Republic of China
    J Comput Chem 31:1592-602. 2010
    Acetohydroxyacid synthase (AHAS) is the first common enzyme in the biosynthetic pathway leading to the production of various branched-chain amino acids...
  78. doi Inactivation of the ilvB1 gene in Mycobacterium tuberculosis leads to branched-chain amino acid auxotrophy and attenuation of virulence in mice
    Disha Awasthy
    AstraZeneca R and D, Bellary Road, Hebbal, Bangalore 560024, India
    Microbiology 155:2978-87. 2009
    Acetohydroxyacid synthase (AHAS) is the first enzyme in the branched-chain amino acid biosynthesis pathway in bacteria...
  79. ncbi Role of a conserved arginine in the mechanism of acetohydroxyacid synthase: catalysis of condensation with a specific ketoacid substrate
    Stanislav Engel
    Department of Life Sciences, Ben Gurion University of the Negev, POB 653, 84105 Beer Sheva, Israel
    J Biol Chem 279:24803-12. 2004
    The thiamin diphosphate (ThDP)-dependent bio-synthetic enzyme acetohydroxyacid synthase (AHAS) catalyzes decarboxylation of pyruvate and specific condensation of the resulting ThDP-bound two-carbon intermediate, hydroxyethyl-ThDP anion/..
  80. ncbi The crystal structures of Klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactor and with an unusual intermediate
    Siew Siew Pang
    Department of Biochemistry and Molecular Biology, The University of Queensland, Brisbane, Queensland 4072, Australia
    J Biol Chem 279:2242-53. 2004
    Acetohydroxyacid synthase (AHAS) and acetolactate synthase (ALS) are thiamine diphosphate (ThDP)-dependent enzymes that catalyze the decarboxylation of pyruvate to give a cofactor-bound hydroxyethyl group, which is transferred to a second ..
  81. ncbi External quality assessment of automated hematology analyzer performance using fresh human blood samples in Shanghai
    Hu Xiaobo
    Shanghai Centre for Clinical Laboratory, Shanghai, Peoples Republic of China
    Lab Hematol 9:175-8. 2003
    We set out to assess the performance and degree of agreement for the different automated hematology analyzers (AHAs) currently used within the Shanghai region...
  82. ncbi Kinetics and mechanism of acetohydroxy acid synthase isozyme III from Escherichia coli
    N Gollop
    Department of Biology, Ben Gurion University of the Negev, Beer Sheva, Israel
    Biochemistry 28:6310-7. 1989
    Acetohydroxy acid synthase (AHAS, EC 4.1.3...
  83. ncbi Metabonomics classifies pathways affected by bioactive compounds. Artificial neural network classification of NMR spectra of plant extracts
    Karl Heinz Ott
    BASF Agro Research, Princeton, NJ 08543, USA
    Phytochemistry 62:971-85. 2003
    ..represent various biochemical modes-of-action such as inhibition of specific enzymes (acetohydroxy acid synthase [AHAS], protoporphyrin IX oxidase [PROTOX], 5-enolpyruvylshikimate-3-phosphate synthase [EPSPS], acetyl CoA carboxylase [..
  84. ncbi Crystal structure of yeast acetohydroxyacid synthase: a target for herbicidal inhibitors
    Siew Siew Pang
    Centre for Protein Structure Function and Engineering, Department of Biochemistry and Molecular Biology, School of Molecular and Microbial Sciences, The University of Queensland, Brisbane, QLD 4072, Australia
    J Mol Biol 317:249-62. 2002
    Acetohydroxyacid synthase (AHAS; EC 4.1.3.18) catalyzes the first step in branched-chain amino acid biosynthesis...
  85. ncbi New directions in skin care
    C P Clark
    Clin Plast Surg 28:745-50. 2001
    Tretinoin and AHAs are dependable components of any skin-rejuvenation program. These products are well studied, and the results are predictable...
  86. ncbi Binding and activation of thiamin diphosphate in acetohydroxyacid synthase
    A Bar-Ilan
    Department of Life Sciences, Ben Gurion University of the Negev, P O B 653, Beer Sheva 84105, Israel
    Biochemistry 40:11946-54. 2001
    ..b>AHAS catalyzes the condensation of the 2-carbon moiety, derived from the decarboxylation of pyruvate, with a second 2-..
  87. pmc A role of proton transfer in peroxidase-catalyzed process elucidated by substrates docking calculations
    J Kulys
    Department of Enzyme Chemistry, Institute of Biochemistry, Mokslininku 12, Vilnius, 2600, Lithuania
    BMC Struct Biol 1:3. 2001
    Previous kinetic investigations of fungal-peroxidase catalyzed oxidation of N-aryl hydroxamic acids (AHAs) and N-aryl-N-hydroxy urethanes (AHUs) revealed that the rate of reaction was independent of the formal redox potential of ..
  88. ncbi Identification of the regulatory subunit of Arabidopsis thaliana acetohydroxyacid synthase and reconstitution with its catalytic subunit
    Y T Lee
    Centre for Protein Structure, Function and Engineering, Department of Biochemistry and Molecular Biology, University of Queensland, Brisbane QLD Australia 4072
    Biochemistry 40:6836-44. 2001
    Acetohydroxyacid synthase (EC 4.1.3.18; AHAS) catalyzes the initial step in the formation of the branched-chain amino acids...
  89. ncbi Cloning and phylogenetic analysis of the genes encoding acetohydroxyacid synthase from the archaeon Methanococcus aeolicus
    T L Bowen
    Department of Microbiology, University of Georgia, Athens 30602 2605, USA
    Gene 188:77-84. 1997
    The gene for acetohydroxyacid synthase (AHAS) was cloned from the archaeon Methanococcus aeolicus. Contrary to biochemical studies [Xing, R. and Whitman, W.B. (1994) J. Bacteriol...
  90. ncbi Homology modeling of the structure of bacterial acetohydroxy acid synthase and examination of the active site by site-directed mutagenesis
    M Ibdah
    Department of Life Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Biochemistry 35:16282-91. 1996
    Acetohydroxy acid synthase (AHAS, EC 4.1.3.18) catalyzes the thiamin pyrophosphate (TPP)-dependent decarboxylation of pyruvate and condensation of the resulting two-carbon moiety with a second alpha-keto acid...
  91. ncbi A human homolog of bacterial acetolactate synthase genes maps within the CADASIL critical region
    A Joutel
    INSERM U25, Paris, France
    Genomics 38:192-8. 1996
    ....
  92. ncbi Molecular cloning, DNA sequencing, and biochemical analyses of Escherichia coli glyoxylate carboligase. An enzyme of the acetohydroxy acid synthase-pyruvate oxidase family
    Y Y Chang
    Department of Microbiology, University of Illinois, Urbana Champaign, 61801
    J Biol Chem 268:3911-9. 1993
    ..acid residues (64,738 Da) that has a high level (30%) of sequence similarity to the acetohydroxy acid synthases (AHAS) of branched chain amino acid synthetic pathway. Significant sequence identity (26%) was also observed with E...
  93. pmc Regulation of Caulobacter crescentus ilvBN gene expression
    J C Tarleton
    Department of Biological Sciences, University of South Carolina, Columbia 29208
    J Bacteriol 176:3765-74. 1994
    ..crescentus to regulate gene expression, the ilvBN genes encoding the two subunits of an acetohydroxy acid synthase (AHAS) have been characterized. Analysis of the DNA sequences indicated that the C...
  94. ncbi Electron transfer in acetohydroxy acid synthase as a side reaction of catalysis. Implications for the reactivity and partitioning of the carbanion/enamine form of (alpha-hydroxyethyl)thiamin diphosphate in a "nonredox" flavoenzyme
    Kai Tittmann
    Institut fur Biochemie, Martin Luther Universitat Halle Wittenberg, Kurt Mothes Strasse 3, D 06099 Halle, Germany
    Biochemistry 43:8652-61. 2004
    Acetohydroxy acid synthases (AHAS) are thiamin diphosphate- (ThDP-) and FAD-dependent enzymes that catalyze the first common step of branched-chain amino acid biosynthesis in plants, bacteria, and fungi...
  95. ncbi Substrate range of acetohydroxy acid synthase I from Escherichia coli in the stereoselective synthesis of alpha-hydroxy ketones
    Stanislav Engel
    Department of Biotechnology Engineering, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Biotechnol Bioeng 88:825-31. 2004
    Acetohydroxy acid synthase I appears to be the most effective of the AHAS isozymes found in Escherichia coli in the chiral synthesis of phenylacetyl carbinol from pyruvate and benzaldehyde...
  96. ncbi Imidazolinone-tolerant crops: history, current status and future
    Siyuan Tan
    BASF Corporation, 26 Davis Drive, Research Triangle Park, NC 27709 3528, USA
    Pest Manag Sci 61:246-57. 2005
    ..imazamox, imazamethabenz and imazaquin, control weeds by inhibiting the enzyme acetohydroxyacid synthase (AHAS), also called acetolactate synthase (ALS)...
  97. doi Design and synthesis of N-2,6-difluorophenyl-5-methoxyl-1,2,4-triazolo[1,5-a]-pyrimidine-2-sulfonamide as acetohydroxyacid synthase inhibitor
    Chao Nan Chen
    Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, PR China
    Bioorg Med Chem 17:3011-7. 2009
    ..31x10(-6) M and 3.60x10(-7) M against Arabidopsis thaliana AHAS, respectively...
  98. ncbi Monitoring the acetohydroxy acid synthase reaction and related carboligations by circular dichroism spectroscopy
    Michael Vinogradov
    Department of Life Sciences, Ben Gurion University of the Negev, P O Box 653, Beer Sheva, 84105, Israel
    Anal Biochem 342:126-33. 2005
    Acetohydroxy acid synthase (AHAS) and related enzymes catalyze the production of chiral compounds [(S)-acetolactate, (S)-acetohydroxybutyrate, or (R)-phenylacetylcarbinol] from achiral substrates (pyruvate, 2-ketobutyrate, or benzaldehyde)..
  99. pmc Acetohydroxyacid synthase, a novel target for improvement of L-lysine production by Corynebacterium glutamicum
    Bastian Blombach
    Institute of Microbiology and Biotechnology, University of Ulm, 89069 Ulm, Germany
    Appl Environ Microbiol 75:419-27. 2009
    The influence of acetohydroxy acid synthase (AHAS) on L-lysine production by Corynebacterium glutamicum was investigated. An AHAS with a deleted C-terminal domain in the regulatory subunit IlvN was engineered by truncating the ilvN gene...
  100. doi Development of chitosan-coated liposomes for sustained delivery of tamarind fruit pulp's extract to the skin
    M Phetdee
    Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand
    Int J Cosmet Sci 30:285-95. 2008
    ..To entrap lyophilized tamarind extract containing alpha-hydroxy acids (AHAs) together with tartaric acid, the reverse phase evaporation method was used to obtain well-formed liposomes loaded ..
  101. doi Biolistic-mediated genetic transformation of cowpea (Vigna unguiculata) and stable Mendelian inheritance of transgenes
    Nayche L Ivo
    EMBRAPA Recursos Geneticos e Biotecnologia, PqEB W5 Norte, Asa Norte, Brasilia, DF, 70770 200, Brazil
    Plant Cell Rep 27:1475-83. 2008
    ..use of the herbicide imazapyr to select transformed meristematic cells after physical introduction of the mutated ahas gene (coding for a mutated acetohydroxyacid synthase, under control of the ahas 5' regulatory sequence) and a ..

Research Grants1

  1. TRANSLATIONAL CONTROL OF TRANSCRIPTION TERMINATION
    G Hatfield; Fiscal Year: 1990
    ..We further propose to determine the molecular mechanisms responsible for the regulation of the ilvYC gene and the valyl-tRNA synthetase gene, and the roles of the AHAS isozymes in the regulation of isoleucine-valine biosynthesis.