ILVBL

Summary

Gene Symbol: ILVBL
Description: ilvB acetolactate synthase like
Alias: 209L8, AHAS, HACL1L, ILV2H, acetolactate synthase-like protein, 2-hydroxyacyl-CoA lyase 1 like, acetolactate synthase homolog, ilvB (bacterial acetolactate synthase)-like, ilvB-like protein
Species: human

Top Publications

  1. ncbi Isolation and characterization of subunits of acetohydroxy acid synthase isozyme III and reconstitution of the holoenzyme
    M Vyazmensky
    Department of Life Science, Ben Gurion University of the Negev, Israel
    Biochemistry 35:10339-46. 1996
  2. ncbi Antigen specificity of antihistone antibodies in connective tissue disease patients with anti-U1RNP antibodies
    Takamasa Wayaku
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Rheumatol Int 28:113-9. 2007
  3. ncbi The distribution of acetohydroxyacid synthase in soil bacteria
    Darryl R Nelson
    School of Molecular and Microbial Biosciences, University of Sydney, Sydney, NSW, 2006, Australia
    Antonie Van Leeuwenhoek 93:123-32. 2008
  4. ncbi [Construction of a new brewing yeast strain with secretive alpha-amylase activity and reduced diacetyl production]
    Feng Zhang
    Laboratory of Molecular Genetics and Breeding of Yeast, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
    Sheng Wu Gong Cheng Xue Bao 24:837-43. 2008
  5. pmc Isoleucine synthesis in Corynebacterium glutamicum: molecular analysis of the ilvB-ilvN-ilvC operon
    C Keilhauer
    Institut fur Biotechnologie, Forschungszentrum, Julich, Germany
    J Bacteriol 175:5595-603. 1993
  6. pmc Common ancestry of Escherichia coli pyruvate oxidase and the acetohydroxy acid synthases of the branched-chain amino acid biosynthetic pathway
    Y Y Chang
    Department of Microbiology, University of Illinois, Urbana 61801
    J Bacteriol 170:3937-45. 1988
  7. doi Factors enhancing L-valine production by the growth-limited L-isoleucine auxotrophic strain Corynebacterium glutamicum DeltailvA DeltapanB ilvNM13 (pECKAilvBNC)
    Ilze Denina
    Institute of Microbiology and Biotechnology, University of Latvia, Kronvalda boulevard 4, 1586 Riga, Latvia
    J Ind Microbiol Biotechnol 37:689-99. 2010
  8. ncbi End-product control of enzymes of branched-chain amino acid biosynthesis in Streptomyces coelicolor
    C A Potter
    Department of Genetics, University of Leeds, UK
    Microbiology 142:1945-52. 1996
  9. ncbi Pharmacology of RALGA, a mixture of retinaldehyde and glycolic acid
    Christian Tran
    Department of Dermatology, University Hospital, Geneva, Switzerland
    Dermatology 210:6-13. 2005
  10. doi Genetic analysis of pathway regulation for enhancing branched-chain amino acid biosynthesis in plants
    Hao Chen
    Donald Danforth Plant Science Center, St Louis, MO 63132, USA
    Plant J 63:573-83. 2010

Scientific Experts

Detail Information

Publications146 found, 100 shown here

  1. ncbi Isolation and characterization of subunits of acetohydroxy acid synthase isozyme III and reconstitution of the holoenzyme
    M Vyazmensky
    Department of Life Science, Ben Gurion University of the Negev, Israel
    Biochemistry 35:10339-46. 1996
    The separately cloned large and small subunits of AHAS isozyme III from Escherichia coli have been isolated and purified. The essentially pure small subunit (17 kDa ilvH product) was obtained by a procedure exploiting its low solubility...
  2. ncbi Antigen specificity of antihistone antibodies in connective tissue disease patients with anti-U1RNP antibodies
    Takamasa Wayaku
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Rheumatol Int 28:113-9. 2007
    ..However, both IgG and IgM AHAs against outer portion of chromatin (H1, H2A, or H2B) were generally higher in SLE compared with other diseases...
  3. ncbi The distribution of acetohydroxyacid synthase in soil bacteria
    Darryl R Nelson
    School of Molecular and Microbial Biosciences, University of Sydney, Sydney, NSW, 2006, Australia
    Antonie Van Leeuwenhoek 93:123-32. 2008
    ..synthase, allowing the bacteria to grow in the presence of valine (which causes feedback inhibition of AHAS I) or the sulfonylurea herbicide triasulfuron (which inhibits AHAS II) although a slight lag phase was observed in ..
  4. ncbi [Construction of a new brewing yeast strain with secretive alpha-amylase activity and reduced diacetyl production]
    Feng Zhang
    Laboratory of Molecular Genetics and Breeding of Yeast, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
    Sheng Wu Gong Cheng Xue Bao 24:837-43. 2008
    ..was inserted in the ILV2 locus of industrial brewer's yeast strain YSF-5 encoding alpha-acetolactate synthase (AHAS) by homologous recombination...
  5. pmc Isoleucine synthesis in Corynebacterium glutamicum: molecular analysis of the ilvB-ilvN-ilvC operon
    C Keilhauer
    Institut fur Biotechnologie, Forschungszentrum, Julich, Germany
    J Bacteriol 175:5595-603. 1993
    Acetohydroxy acid synthase (AHAS) and isomeroreductase (IR) catalyze subsequent reactions in the flux of metabolites towards isoleucine, valine, leucine, and pantothenate...
  6. pmc Common ancestry of Escherichia coli pyruvate oxidase and the acetohydroxy acid synthases of the branched-chain amino acid biosynthetic pathway
    Y Y Chang
    Department of Microbiology, University of Illinois, Urbana 61801
    J Bacteriol 170:3937-45. 1988
    ..The best studied of these enigmatic nonredox flavoproteins are the acetohydroxy acid synthases (AHAS), which catalyze early steps in the synthesis of branched-chain amino acids in bacteria, yeasts, and plants...
  7. doi Factors enhancing L-valine production by the growth-limited L-isoleucine auxotrophic strain Corynebacterium glutamicum DeltailvA DeltapanB ilvNM13 (pECKAilvBNC)
    Ilze Denina
    Institute of Microbiology and Biotechnology, University of Latvia, Kronvalda boulevard 4, 1586 Riga, Latvia
    J Ind Microbiol Biotechnol 37:689-99. 2010
    ..A sharp increase in acetohydroxy acid synthase (AHAS) activity, a slight increase in acetohydroxyacid isomeroreductase (AHAIR) activity, and a dramatic increase in L: -..
  8. ncbi End-product control of enzymes of branched-chain amino acid biosynthesis in Streptomyces coelicolor
    C A Potter
    Department of Genetics, University of Leeds, UK
    Microbiology 142:1945-52. 1996
    ..on end-product control in the model organism Streptomyces coelicolor of the enzymes acetohydroxy acid synthase (AHAS) and isopropylmalate synthase (IPMS), mediating steps in the pathways to isoleucine-valine and leucine respectively...
  9. ncbi Pharmacology of RALGA, a mixture of retinaldehyde and glycolic acid
    Christian Tran
    Department of Dermatology, University Hospital, Geneva, Switzerland
    Dermatology 210:6-13. 2005
    Retinoids and alpha-hydroxy acids (AHAs) are major compounds in topical therapy. They exert distinct but potentially complementary activities. However, their association is limited by their respective irritating potential...
  10. doi Genetic analysis of pathway regulation for enhancing branched-chain amino acid biosynthesis in plants
    Hao Chen
    Donald Danforth Plant Science Center, St Louis, MO 63132, USA
    Plant J 63:573-83. 2010
    ..Map-based cloning revealed that VAT1 encodes a regulatory subunit of acetohydroxy acid synthase (AHAS), the first committed enzyme in the BCAA biosynthesis pathway...
  11. doi Interactions between large and small subunits of different acetohydroxyacid synthase isozymes of Escherichia coli
    Maria Vyazmensky
    Department of Life Sciences, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Biochemistry 48:8731-7. 2009
    ..subunits (LSUs; ilvB, ilvG and ilvI, respectively) of enterobacterial acetohydroxyacid synthases isozymes (AHAS I, II and III) have molecular weights approximately 60 kDa and are paralogous with a family of other thiamin ..
  12. doi Valine 375 and phenylalanine 109 confer affinity and specificity for pyruvate as donor substrate in acetohydroxy acid synthase isozyme II from Escherichia coli
    Andrea Steinmetz
    Albrecht von Haller Institute and Göttingen Centre for Molecular Biosciences, Ernst Caspari Haus, Department of Bioanalytics, Georg August University Gottingen, Justus von Liebig Weg 11, Germany
    Biochemistry 49:5188-99. 2010
    Acetohydroxy acid synthase (AHAS) is a thiamin diphosphate-dependent enzyme that catalyzes the condensation of pyruvate with either another pyruvate molecule (product acetolactate) or 2-ketobutyrate (product acetohydroxybutyrate) as the ..
  13. doi Antiproliferative effects of lactic acid via the induction of apoptosis and cell cycle arrest in a human keratinocyte cell line (HaCaT)
    Yu Ping Hsiao
    Department of Dermatology, Chung Shan Medical University Hospital, Taichung, Taiwan, ROC
    J Dermatol Sci 54:175-84. 2009
    Alpha-hydroxy acids (AHAs) have been widely used in cosmetic industry. However, knowledge on cytotoxicity of AHAs in human keratinocytes is limited.
  14. ncbi Cloning and sequence determination of the acetohydroxy acid synthase genes from Brevibacterium flavum MJ233 by using the polymerase chain reaction
    M Inui
    Tsukuba Research Center, Mitsubishi Petrochemical Co, Ltd, Ibaraki, Japan
    DNA Seq 3:303-10. 1993
    Taking advantage of highly conserved domains present in the three acetohydroxy acid synthase (AHAS) isozymes from E. coli K-12, we designed degenerate oligonucleotides corresponding to these regions...
  15. doi Docking and 3D-QSAR studies of acetohydroxy acid synthase inhibitor sulfonylurea derivatives
    Kunal Roy
    Drug Theoretics and Cheminformatics Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, 700032, India
    J Mol Model 16:951-64. 2010
    ..quantitative-structure activity relationship (3D-QSAR) studies were performed on acetohydroxy acid synthase (AHAS) inhibitor sulfonylurea analogues with potential herbicidal activity...
  16. ncbi Expression, purification, characterization, and reconstitution of the large and small subunits of yeast acetohydroxyacid synthase
    S S Pang
    Centre for Protein Structure, Function and Engineering, Department of Biochemistry, The University of Queensland, Brisbane, Australia
    Biochemistry 38:5222-31. 1999
    Acetohydroxyacid synthase (AHAS, EC 4.1.3.18) catalyzes the first step in the biosynthesis of the branched-chain amino acids...
  17. doi Hydroxycarbonyl anion (m/z 45), a diagnostic marker for alpha-hydroxy carboxylic acids
    Jason B Bialecki
    Center for Mass Spectrometry, Department of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, New Jersey 07030, USA
    J Mass Spectrom 44:252-9. 2009
    Collision-induced dissociation mass spectra of anions derived from alpha-hydroxy carboxylic acids (AHAs) show a diagnostic peak at m/z 45...
  18. doi Crystal structures of two novel sulfonylurea herbicides in complex with Arabidopsis thaliana acetohydroxyacid synthase
    Jian guo Wang
    State Key Laboratory of Elemento organic Chemistry, National Pesticide Engineering Research Center, Nankai University, Tianjin, China
    FEBS J 276:1282-90. 2009
    Acetohydroxyacid synthase (AHAS; EC 2.2.1.6) is the first enzyme in the biosynthetic pathway of the branched-chain amino acids...
  19. doi Deregulation of acetohydroxy-acid synthase: Loss of allosteric inhibition conferred by mutations in the catalytic subunit
    J Kopecky
    Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Folia Microbiol (Praha) 53:467-71. 2008
    Acetohydroxy-acid synthases (AHAS) of two mutant strains Streptomyces cinnamonensis ACB-NLR-2 and BVR-18 were chosen for this study for their apparent activation by valine, which regularly acts as an allosteric inhibitor...
  20. pmc Crystal structures of TM0549 and NE1324--two orthologs of E. coli AHAS isozyme III small regulatory subunit
    Janusz J Petkowski
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville 22908, USA
    Protein Sci 16:1360-7. 2007
    Crystal structures of two orthologs of the regulatory subunit of acetohydroxyacid synthase III (AHAS, EC 2.2.1...
  21. doi Production of 2-methyl-1-butanol in engineered Escherichia coli
    Anthony F Cann
    Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA 90095, USA
    Appl Microbiol Biotechnol 81:89-98. 2008
    ..we explored the biodiversity of enzymes catalyzing key parts of the isoleucine biosynthetic pathway, finding that AHAS II (ilvGM) from Salmonella typhimurium and threonine deaminase (ilvA) from Corynebacterium glutamicum improve 2MB ..
  22. ncbi The ilvG gene is expressed in Escherichia coli K-12
    C M Berg
    Gene 12:165-70. 1980
    Three genes code for isozymes of acetohydroxy acid synthase (AHAS) in Escherichia coli K-12...
  23. ncbi Acetohydroxy acid synthase and threonine deaminase activities, and the biosynthesis of isoleucine-leucine-valine in Streptococcus bovis
    A L Basso
    Istituto Adattamento Bovini e Bufali Ambiente Mezzogiorno, C N R, Naples, Italy
    Res Microbiol 144:539-45. 1993
    Acetohydroxy acid synthase (AHAS) and threonine deaminase (TD) activities were found in Streptococcus bovis and shown to be involved in the biosynthesis of the branched chain amino acids isoleucine, leucine and valine...
  24. ncbi Acetohydroxyacid synthase from Mycobacterium avium and its inhibition by sulfonylureas and imidazolinones
    Yehudit Zohar
    Department of Life Sciences, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Biochim Biophys Acta 1649:97-105. 2003
    ..To this end, we cloned, overexpressed, purified and characterised for the first time an acetohydroxyacid synthase (AHAS), a key enzyme in the pathway to the biosynthesis of the BCAAs, from the genus Mycobacterium...
  25. ncbi Systematic characterization of mutations in yeast acetohydroxyacid synthase. Interpretation of herbicide-resistance data
    Ronald G Duggleby
    Department of Biochemistry and Molecular Biology, The University of Queensland, Brisbane, QLD 4072, Australia
    Eur J Biochem 270:2895-904. 2003
    Acetohydroxyacid synthase (AHAS, EC 4.1.3.18) catalyses the first step in branched-chain amino acid biosynthesis and is the target for sulfonylurea and imidazolinone herbicides, which act as potent and specific inhibitors...
  26. ncbi A novel selection system for potato transformation using a mutated AHAS gene
    M Andersson
    Plant Science Sweden AB, Herman Ehles Väg 2 4, 268 31 Svalöv, Sweden
    Plant Cell Rep 22:261-7. 2003
    Acetohydroxyacid synthase (AHAS) is the target enzyme for a number of herbicides. A S653N mutation in the AHAS gene results in an increased tolerance to imidazolinone herbicides...
  27. pmc Cloning and characterization of acetohydroxyacid synthase from Bacillus stearothermophilus
    Iris Porat
    Department of Life Sciences, Ben Gurion University of the Negev, Beer Sheva, 84105 Israel
    J Bacteriol 186:570-4. 2004
    Five genes from the ilv-leu operon from Bacillus stearothermophilus have been sequenced. Acetohydroxyacid synthase (AHAS) and its subunits were separately cloned, purified, and characterized...
  28. ncbi Acetohydroxyacid synthase mutations conferring resistance to imidazolinone or sulfonylurea herbicides in sunflower
    Judith M Kolkman
    Department of Crop and Soil Science, Oregon State University, Corvallis, OR 97331, USA
    Theor Appl Genet 109:1147-59. 2004
    ..and other crops in North America, and are commonly controlled by applying acetohydroxyacid synthase (AHAS)-inhibiting herbicides...
  29. pmc The carboligation reaction of acetohydroxyacid synthase II: steady-state intermediate distributions in wild type and mutants by NMR
    Kai Tittmann
    Department of Life Sciences, Ben Gurion University of the Negev, 84105 Beer Sheva, Israel
    Proc Natl Acad Sci U S A 102:553-8. 2005
    The thiamin diphosphate (ThDP)-dependent enzyme acetohydroxyacid synthase (AHAS) catalyzes the first common step in branched-chain amino acid biosynthesis...
  30. ncbi Two consecutive aspartic acid residues conferring herbicide resistance in tobacco acetohydroxy acid synthase
    Dung Tien Le
    School of Life Sciences, Chungbuk National University, Cheongju 361 763, South Korea
    Biochim Biophys Acta 1749:103-12. 2005
    Acetohydroxy acid synthase (AHAS) catalyzes the first common step in the biosynthesis pathway of the branch chain amino acids in plants and microorganisms...
  31. ncbi A comparative risk assessment of genetically engineered, mutagenic, and conventional wheat production systems
    Robert K D Peterson
    Agricultural and Biological Risk Assessment, Montana State University, Bozeman, 59717 3120, USA
    Transgenic Res 14:859-75. 2005
    ..Risk for mutated AHAS protein in imidazolinone-tolerant wheat most likely would be low, but there are not sufficient effect and exposure ..
  32. ncbi A mutation in the herbicide target site acetohydroxyacid synthase produces morphological and structural alterations and reduces fitness in Amaranthus powellii
    François J Tardif
    Department of Plant Agriculture, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
    New Phytol 169:251-64. 2006
    ..The Trp(574)Leu acetohydroxyacid synthase (AHAS) mutation appears to have considerable pleiotropic effects on the early growth and development of the plants which, ..
  33. ncbi Herbicidal inhibitors of amino acid biosynthesis and herbicide-tolerant crops
    S Tan
    BASF Corporation, Research Triangle Park, North Carolina 27709, USA
    Amino Acids 30:195-204. 2006
    Acetohydroxyacid synthase (AHAS) inhibitors interfere with branched-chain amino acid biosynthesis by inhibiting AHAS. Glyphosate affects aromatic amino acid biosynthesis by inhibiting 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS)...
  34. ncbi Antihistone antibodies in linear scleroderma variants
    Rokea A el-Azhary
    Department of Dermatology, Mayo Clinic, Rochester, MN 55905, USA
    Int J Dermatol 45:1296-9. 2006
    ..Antihistone antibodies (AHAs), which traditionally are markers for drug-induced lupus, may also be linked to linear scleroderma.
  35. ncbi Comparative genotoxicity evaluation of imidazolinone herbicides in somatic cells of Drosophila melanogaster
    Edson José Fragiorge
    Universidade Federal de Uberlandia, Instituto de Genética e Bioquímica, Laboratório de Mutagênese, Av Para 1720, Campus Umuarama, 38400 902 Uberlândia, MG, Brazil
    Food Chem Toxicol 46:393-401. 2008
    ..are classified as imidazolinone (IMI) herbicides and their mode of action is to inhibit acetohydroxyacid synthase (AHAS), an enzyme involved in the biosynthesis of the amino acids leucine, isoleucine and valine...
  36. doi Anti-hypothalamus and anti-pituitary antibodies may contribute to perpetuate the hypopituitarism in patients with Sheehan's syndrome
    Annamaria De Bellis
    Department of Clinical and Experimental Medicine and Surgery F Magrassi, A Lanzara, Second University of Naples, via Pansini N 5, 80131 Napoli, Italy
    Eur J Endocrinol 158:147-52. 2008
    ..detected in some patients with Sheehan's syndrome (SS) suggesting an autoimmune pituitary involvement in the development of their hypopituitarism, hypothalamic cell anti-hypothalamus antibodies (AHAs) have not been investigated so far.
  37. doi Topical proteolytic enzymes affect epidermal and dermal properties
    W P Smith
    Dermac Inc, New Canaan, CT 06840, USA
    Int J Cosmet Sci 29:15-21. 2007
    ..Such improvements are the result of changes to the epidermis and dermis and are strikingly similar to results observed with higher concentrations of AHAs (alpha hydroxy acids).
  38. doi Molecular and biochemical characterization of an induced mutation conferring imidazolinone resistance in sunflower
    Carlos A Sala
    Biotechnology Department, NIDERA S A, Ruta 8 km 376, Casilla de Correo 6, 2600, Venado Tuerto, Santa Fe, Argentina
    Theor Appl Genet 118:105-12. 2008
    ..This pattern was in close association with the AHAS-inhibition kinetics of protein extracts of CLHA-Plus challenged with different doses of imazamox and chlorsulfuron...
  39. doi Association between extended-release niacin treatment and glycemic control in patients with type 2 diabetes mellitus: analysis of an administrative-claims database
    Baishali M Ambegaonkar
    Global Health Outcomes, Merck and Co, Inc, Whitehouse Station, NJ 08889 0100, USA
    Metabolism 60:1038-44. 2011
    The aim of the study was to evaluate trends in antihyperglycemic agents (AHAs) use in patients with type 2 diabetes mellitus (T2DM) newly initiating extended-release niacin (ERN) compared with other lipid-modifying therapy (LMT)...
  40. doi Inheritance and molecular characterization of broad range tolerance to herbicides targeting acetohydroxyacid synthase in sunflower
    Carlos A Sala
    Biotechnology Department, NIDERA S A, Ruta 8 km 376, Casilla de Correo 6, 2600, Venado Tuerto, Santa Fe, Argentina
    Theor Appl Genet 124:355-64. 2012
    ..The objectives of this work were to determine the relative level and pattern of cross-tolerance to different AHAS-inhibiting herbicides, the mode of inheritance, and the molecular basis of herbicide tolerance in this line...
  41. ncbi In vitro efficacy of acetohydroxyacid synthase inhibitors against clinical strains of Mycobacterium tuberculosis isolated from a hospital in Beijing, China
    Mei Dong
    Department of Clinical Laboratory, 309th Hospital of Chinese People s Liberation Army, Beijing, China
    Saudi Med J 32:1122-6. 2011
    To assess the efficacy of acetohydroxyacid synthase (AHAS) inhibitors against Mycobacterium tuberculosis from China, including multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) strains.
  42. doi Health and nutritional status of Wistar rats following subchronic exposure to CV127 soybeans
    Amechi Chukwudebe
    BASF Corporation, 26 Davis Drive, Research Triangle Park, NC 27709, USA
    Food Chem Toxicol 50:956-71. 2012
    ..Hence, introduction of AHAS gene into soybeans does not substantially alter its compositional properties, nor adversely affect its nutritional ..
  43. doi Spread of herbicide-resistant weedy rice (red rice, Oryza sativa L.) after 5 years of Clearfield rice cultivation in Italy
    M Busconi
    Institute of Agronomy, Genetics and Field Crops, Universita Cattolica del Sacro Cuore, Piacenza, Italy
    Plant Biol (Stuttg) 14:751-9. 2012
    ..Clearfield (Cl) varieties, which are resistant to the inhibiting herbicides in the chemical group AHAS (acetohydroxyacid synthase), provide a highly efficient opportunity to control red rice infestations...
  44. doi Cloning, mutagenesis, and characterization of the microalga Parietochloris incisa acetohydroxyacid synthase, and its possible use as an endogenous selection marker
    Omer Grundman
    Microalgal Biotechnology Laboratory, French Associates Institute of Agriculture and Biotechnology of Drylands, The Jacob Blaustein Institutes for Desert Research, Ben Gurion University of the Negev, Midreshet Ben Gurion, Israel
    Biotechnol Bioeng 109:2340-8. 2012
    ..b>AHAS is present in plants and microorganisms where it catalyzes the first essential step in the synthesis of branched-..
  45. doi Synthesis and biological evaluation of nonsymmetrical aromatic disulfides as novel inhibitors of acetohydroxyacid synthase
    Zai Shun Li
    State Key Laboratory and Institute of Elemento Organic Chemistry, Nankai University, Tianjin 300071, PR China
    Bioorg Med Chem Lett 23:3723-7. 2013
    ..groups were synthesized and their biological activities were evaluated as inhibitors of acetohydroxyacid synthase (AHAS, EC 2.2.1.6)...
  46. doi How important is the synclinal conformation of sulfonylureas to explain the inhibition of AHAS: a theoretical study
    Gonzalo A Jaña
    Departamento de CienciasQuímicas, Facultad de Ciencias Exactas, Sede Concepción, Universidad Andres Bello, Concepcion, Chile
    J Chem Inf Model 54:926-32. 2014
    The inhibitory activity of 15 sulfonylureas on acetohydroxyacid synthase (AHAS) is addressed theoretically in order to stress how important the conformation is to explain their differences as AHAS inhibitors...
  47. doi Chemically tunable ionic liquids with aprotic heterocyclic anion (AHA) for CO(2) capture
    Samuel Seo
    Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, Indiana 46556, United States
    J Phys Chem B 118:5740-51. 2014
    Ionic liquids (ILs) with aprotic heterocyclic anions, or AHAs, can bind CO2 with reaction enthalpies that are suitable for gas separations and without suffering large viscosity increases...
  48. doi Genetic characterization of the acetohydroxyacid synthase (AHAS) gene responsible for resistance to imidazolinone in chickpea (Cicer arietinum L.)
    Courtney Thompson
    Department of Plant Sciences, Crop Development Centre, University of Saskatchewan, Saskatoon, SK, S7N 5A8, Canada
    Theor Appl Genet 127:1583-91. 2014
    ..In many plant species, resistance to IMI is caused by point mutation(s) in the acetohydroxyacid synthase (AHAS) gene resulting in an amino acid substitution preventing herbicide attachment to the molecule...
  49. doi Acetohydroxyacid synthase activity and transcripts profiling reveal tissue-specific regulation of ahas genes in sunflower
    Ana C Ochogavía
    Laboratorio de Biologia Molecular, Facultad de Ciencias Agrarias, Universidad Nacional de Rosario, CC 14, S2125ZAA Zavalla, Argentina CONICET, Facultad de Ciencias Agrarias, Universidad Nacional de Rosario, CC 14, S2125ZAA Zavalla, Argentina Electronic address
    Plant Sci 224:144-50. 2014
    Acetohydroxyacid synthase (AHAS) is the target site of several herbicides and catalyses the first step in the biosynthesis of branched chain amino acid...
  50. doi Different cross-resistance patterns to AHAS herbicides of two tribenuron-methyl resistant flixweed (Descurainiasophia L.) biotypes in China
    Wei Deng
    Department of Applied Chemistry, China Agricultural University, No 2 of Yuan Ming Yuan Xilu, Haidian District, Beijing 100193, China
    Pestic Biochem Physiol 112:26-32. 2014
    ..Two flixweed accessions, HB08 and HB16 with a Pro-197-Leu and Pro-197-Ser AHAS-mutation respectively, have evolved very high levels resistance to sulfonylurea (SU) herbicide, tribenuron-methyl...
  51. doi L-Serine overproduction with minimization of by-product synthesis by engineered Corynebacterium glutamicum
    Qinjian Zhu
    School of Pharmaceutics Science, Jiangnan University, Wuxi, 214122, People s Republic of China
    Appl Microbiol Biotechnol 99:1665-73. 2015
    ..of alaT and avtA encoding the transaminases and introduction of an attenuated mutant of acetohydroxyacid synthase (AHAS) increased both L-serine production level (26.23 g/L) and its productivity (0.27 g/L/h)...
  52. doi Analysis of acetohydroxyacid synthase1 gene in chickpea conferring resistance to imazamox herbicide
    Parul Jain
    Crop Development Centre, Department of Plant Sciences, University of Saskatchewan, Saskatoon, SK S7N 5A8, Canada
    Genome 57:593-600. 2014
    ..In many plant species, contrasting transcription levels of AHAS gene has been implicated in the resistant and susceptible genotypes in response to IMI...
  53. doi Facile Fabrication of N-Doped Graphene as Efficient Electrocatalyst for Oxygen Reduction Reaction
    Yongliang Liao
    State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, People s Republic of China
    ACS Appl Mater Interfaces 7:19619-25. 2015
    ..It consists of a two-step calcination strategy and uses α-hydroxy acids (AHAs) as carbon source and melamine as nitrogen source...
  54. doi Canagliflozin treatment of Hispanic and non-Hispanic patients with type 2 diabetes in a US managed care setting
    Wing Chow
    a a Health Economics and Outcomes Research, Janssen Scientific Affairs LLC, Raritan, NJ, USA
    Curr Med Res Opin 32:13-22. 2016
    ..Few studies of antihyperglycemic agents (AHAs) have compared H/L with non-H/L patients...
  55. doi Efficacy and safety of canagliflozin in type 2 diabetes mellitus: systematic review of randomized controlled trials
    Rizwana Parveen
    a Centre for Translational and Clinical Research, Jamia Hamdard, New Delhi 110062, India
    Expert Opin Pharmacother 17:105-15. 2016
    Currently available antihyperglycemic agents (AHAs), despite being effective, do not provide adequate glycemic control in some cases and are associated with side effects...
  56. pmc Sulfonylurea use and the risk of hospital readmission in patients with type 2 diabetes
    Pamela C Heaton
    Pharmacy Practice and Administrative Sciences, James L Winkle College of Pharmacy, University of Cincinnati Academic Health Center, Cincinnati, OH, 45267, USA
    BMC Endocr Disord 16:4. 2016
    ..The objective was to compare the risk for diabetes-related hospital readmission in patients with type 2 diabetes treated with sulfonylureas (SUs) compared to those treated with other oral antihyperglycemic agents (AHAs).
  57. doi The kidney and type 2 diabetes mellitus: therapeutic implications of SGLT2 inhibitors
    Matthew R Weir
    a Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
    Postgrad Med 128:290-8. 2016
    ..in recent years with the arrival of sodium-glucose co-transporter 2 (SGLT2) inhibitors - antihyperglycemic agents (AHAs) that specifically target the kidneys...
  58. pmc Canagliflozin: Efficacy and Safety in Combination with Metformin Alone or with Other Antihyperglycemic Agents in Type 2 Diabetes
    Rong Qiu
    Janssen Research and Development, LLC, 920 Route 202 South, Raritan, NJ, 08869, USA
    Diabetes Ther 7:659-678. 2016
    ..were on background therapy that consisted of metformin alone or in combination with other antihyperglycemic agents (AHAs; e.g., pioglitazone, sulfonylurea, and insulin)...
  59. pmc Fixed-Dose Combination of Canagliflozin and Metformin for the Treatment of Type 2 Diabetes: An Overview
    Jaime A Davidson
    Department of Medicine, Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Adv Ther 34:41-59. 2017
    ..goals with metformin monotherapy and require subsequent combination therapy with other antihyperglycemic agents (AHAs)...
  60. ncbi Acetohydroxyacid synthase: a new enzyme for chiral synthesis of R-phenylacetylcarbinol
    Stanislav Engel
    Department of Biotechnology Engineering, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Biotechnol Bioeng 83:833-40. 2003
    We have found that acetohydroxyacid synthase (AHAS) is an efficient catalyst for the enantiospecific (> or =98% enantiomeric excess) synthesis of (R)-phenylacetylcarbinol (R-PAC) from pyruvate and benzaldehyde, despite the fact that ..
  61. ncbi The active site and mechanism of action of recombinant acetohydroxy acid synthase from tobacco
    Moon Young Yoon
    Department of Chemistry, Hanyang University, Seoul 133 791, South Korea
    FEBS Lett 555:185-91. 2003
    Acetohydroxy acid synthase (AHAS) is one of several enzymes that require thiamine diphosphate and a divalent cation as essential cofactors. Recently, the three-dimensional structure of the enzyme from yeast has been determined [Pang et al...
  62. ncbi Characterization of acetohydroxyacid synthase from Mycobacterium tuberculosis and the identification of its new inhibitor from the screening of a chemical library
    Kyoung Jae Choi
    Department of Chemistry, Hanyang University, Seoul 133 791, Korea
    FEBS Lett 579:4903-10. 2005
    Acetohydroxyacid synthase (AHAS) is a thiamin diphosphate- (ThDP-) and FAD-dependent enzyme that catalyzes the first common step in the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine...
  63. ncbi Does lactobionic acid affect the colloidal structure and skin moisturizing potential of the alkyl polyglucoside-based emulsion systems?
    M Z Tasic-Kostov
    Department of Pharmacy, Faculty of Medicine, University of Nis, Serbia
    Pharmazie 66:862-70. 2011
    ..APG)-based emulsion as vehicle for lactobionic acid (LA), advantageous representative of the alphahydroxyacids (AHAs)-multifunctional moisturizers, assessing the safety for use (in vitro acute skin irritation test using cytotoxicity ..
  64. doi Impact of the ahas transgene and of herbicides associated with the soybean crop on soil microbial communities
    Rosinei Aparecida Souza
    Embrapa Soja, Caixa Postal 231, Londrina, Parana, 86001 970, Brazil
    Transgenic Res 22:877-92. 2013
    ..The aim of this study was to evaluate the effects of transgenic soybean containing the ahas gene conferring resistance to herbicides of the imidazolinone group, and of the herbicides associated with ..
  65. doi Biochemical characterization and evaluation of potent inhibitors of the Pseudomonas aeruginosa PA01 acetohydroxyacid synthase
    June Haeng Cho
    Department of Chemistry, Institute of Natural Science, Hanyang University, Seoul 133 791, Republic of Korea
    Biochimie 95:1411-21. 2013
    ..isoleucine via a common biosynthetic pathway in which the first reaction is catalyzed by acetohydroxyacid synthase (AHAS, EC 4.1.3.18). Recently, AHAS was identified as a potential anti bacterial target...
  66. pmc Acetohydroxy acid synthase I, a required enzyme for isoleucine and valine biosynthesis in Escherichia coli K-12 during growth on acetate as the sole carbon source
    F E Dailey
    J Bacteriol 165:453-60. 1986
    Escherichia coli K-12 has two acetohydroxy acid synthase (AHAS) isozymes (AHAS I and AHAS III)...
  67. pmc Stable chloroplast transformation of the unicellular red alga Porphyridium species
    Miri Lapidot
    Department of Life Sciences, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Plant Physiol 129:7-12. 2002
    ..system for Rhodophytes and is based on use of a mutant form of the gene encoding acetohydroxyacid synthase [AHAS(W492S)] as a dominant selectable marker...
  68. ncbi Crystallization of the FAD-independent acetolactate synthase of Klebsiella pneumoniae
    S S Pang
    Centre for Protein Structure, Function and Engineering, Department of Biochemistry and Molecular Biology, School of Molecular and Microbial Sciences The University of Queensland, Brisbane QLD 4072, Australia
    Acta Crystallogr D Biol Crystallogr 58:1237-9. 2002
    ..The enzyme (EC 4.1.3.18) that forms 2-acetolactate is known as either acetohydroxyacid synthase (AHAS) or acetolactate synthase (ALS), with the latter name preferred for the catabolic enzyme...
  69. ncbi Determination of alpha hydroxy acids in fruits by capillary electrophoresis
    Suwanna Vorarat
    Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, 40002, Thailand
    Anal Sci 18:893-6. 2002
    ..5 and 5 micrograms ml-1 for citric acid and malic acid, respectively. AHAs from natural fruit juices (orange and grape) were determined and measured with this method.
  70. pmc Global expression profiling and physiological characterization of Corynebacterium glutamicum grown in the presence of L-valine
    C Lange
    Institut für Biotechnologie 1, Forschungszentrum Julich, D 52425 Julich, Germany
    Appl Environ Microbiol 69:2521-32. 2003
    ..e., the large subunit of acetohydroxyacid synthase (AHAS), and by an increased AHAS activity of valine-treated VAL1 cells...
  71. ncbi Systemic and topical drugs for aging skin
    Michael Kockaert
    Albert Schweitzer Hospital, Department of Dermatology, P O Box 306, 3300 AH Dordrecht, The Netherlands
    J Drugs Dermatol 2:435-41. 2003
    ..The most frequently used topical drugs include retinoids, alpha hydroxy acids (AHAs), vitamin C, beta hydroxy acids, anti-oxidants, and tocopherol...
  72. ncbi Characterisation of the enzyme activities involved in the valine biosynthetic pathway in a valine-producing strain of Corynebacterium glutamicum
    D Leyval
    Laboratoire Bioprocédés Agro Alimentaires, ENSAIA, Institut National Polytechnique de Lorraine 2, avenue de la Forêt de Haye, BP 172, F 54505 Vandoeuvre les Nancy cedex, France
    J Biotechnol 104:241-52. 2003
    ..In this micro-organism, this pathway might involve up to five enzyme activities: acetohydroxy acid synthase (AHAS), acetohydroxy acid isomeroreductase (AHAIR), dihydroxyacid dehydratase and transaminases B and C...
  73. ncbi A polyhydroxy acid skin care regimen provides antiaging effects comparable to an alpha-hydroxyacid regimen
    Brenda L Edison
    NeoStrata Company, Inc, Princeton, New Jersey, USA
    Cutis 73:14-7. 2004
    ..significant evidence that PHAs provide antiaging effects to skin, a direct comparison between alpha-hydroxyacids (AHAs) and PHAs for these effects has not been conducted...
  74. ncbi At the root of its success. AHAs lobbying muscle comes from strong network of local advocates
    Michael Heaney
    University of Chicago, USA
    Mod Healthc 34:23. 2004
  75. ncbi Column flow reactor using acetohydroxyacid synthase I from Escherichia coli as catalyst in continuous synthesis of R-phenylacetyl carbinol
    Stanislav Engel
    Department of Biotechnology Engineering, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Biotechnol Bioeng 89:733-40. 2005
    We tested the possibility of utilizing acetohydroxyacid synthase I (AHAS I) from Escherichia coli in a continuous flow reactor for production of R-phenylacetyl carbinol (R-PAC)...
  76. ncbi Roles of three well-conserved arginine residues in mediating the catalytic activity of tobacco acetohydroxy acid synthase
    Dung Tien Le
    School of Life Sciences, Chungbuk National University, Cheongju 361 763, Korea
    J Biochem 138:35-40. 2005
    Acetohydroxy acid synthase (AHAS, EC 2.2.1.6; also known as acetolactate synthase, ALS) catalyzes the first common step in the biosynthesis of valine, leucine, and isoleucine in plants and microorganisms...
  77. pmc Targeting of the virulence factor acetohydroxyacid synthase by sulfonylureas results in inhibition of intramacrophagic multiplication of Brucella suis
    Rose Anne Boigegrain
    INSERM U 431, Universite Montpellier II, CC 100, Place E Bataillon, F 34095 Montpellier, France
    Antimicrob Agents Chemother 49:3922-5. 2005
    The acetohydroxyacid synthase (AHAS) of Brucella suis can be effectively targeted by the sulfonylureas chlorimuron ethyl and metsulfuron methyl...
  78. ncbi [Production of transgenic pea (Pisum sativum L.) plants resistant to the herbicide pursuit]
    S N Nifantova
    Tsitol Genet 39:16-21. 2005
    Transgenic pea (Pisum sativum L.) plants containing mutant ahas/als gene were obtained using Agrobacterium-mediated genetic transformation...
  79. doi In vitro and ex vivo activity of new derivatives of acetohydroxyacid synthase inhibitors against Mycobacterium tuberculosis and non-tuberculous mycobacteria
    Hosung Sohn
    Department of Microbiology, College of Medicine, Chungnam National University, 6 Munhwa dong, Jung ku, Daejeon 301 747, South Korea
    Int J Antimicrob Agents 31:567-71. 2008
    Sulfometuron methyl (SM) is an inhibitor of acetohydroxyacid synthase (AHAS), the first common enzyme in the branched-chain amino acid biosynthetic pathway, and shows activity against Mycobacterium tuberculosis both in vitro and in vivo...
  80. doi Bacterial acetohydroxyacid synthase and its inhibitors--a summary of their structure, biological activity and current status
    Vinayakumar Gedi
    Department of Chemistry, Institute of Natural Sciences, Hanyang University, Seoul, Korea
    FEBS J 279:946-63. 2012
    Acetohydroxyacid synthase (anabolic AHAS; EC 2.2.1.6) is a thiamin diphosphate-dependent enzyme that catalyzes the first step in the branched-chain amino acid (BCAA) biosynthesis pathway...
  81. pmc Intracellular proton-mediated activation of TRPV3 channels accounts for the exfoliation effect of α-hydroxyl acids on keratinocytes
    Xu Cao
    Department of Neurobiology, Neuroscience Research Institute, Peking University Health Science Center, China
    J Biol Chem 287:25905-16. 2012
    Hydroxyl acids (AHAs) from natural sources act as proton donors and topical compounds that penetrate skin and are well known in the cosmetic industry for their use in chemical peels and improvement of the skin...
  82. doi Evaluation of the in vitro and intracellular efficacy of new monosubstituted sulfonylureas against extensively drug-resistant tuberculosis
    Di Wang
    Department of Clinical Laboratory, The 309th Hospital of Chinese People s Liberation Army, Beijing 100091, China
    Int J Antimicrob Agents 40:463-6. 2012
    Acetohydroxyacid synthase (AHAS) has been regarded as a potential drug target against Mycobacterium tuberculosis as it catalyses the first step in the pathway for biosynthesis of branched-chain amino acids...
  83. doi Sulfonylureas have antifungal activity and are potent inhibitors of Candida albicans acetohydroxyacid synthase
    Yu Ting Lee
    School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane 4072, Queensland, Australia
    J Med Chem 56:210-9. 2013
    The sulfonylurea herbicides exert their activity by inhibiting plant acetohydroxyacid synthase (AHAS), the first enzyme in the branched-chain amino acid biosynthesis pathway...
  84. doi Rural speech-language pathologists' perceptions of working with allied health assistants
    Rachael O'Brien
    The University of Newcastle, Newcastle, Australia
    Int J Speech Lang Pathol 15:613-22. 2013
    ..address the problem of workforce shortages and growing clinical demand by employing allied health assistants (AHAs) to provide clinical and administrative support to AH professionals...
  85. doi Molecular characterization of Als1, an acetohydroxyacid synthase mutation conferring resistance to sulfonylurea herbicides in soybean
    Cecilia Ghio
    Soybean Breeding Program, NIDERA S A, Tucuman, Argentina
    Theor Appl Genet 126:2957-68. 2013
    The AHAS gene family in soybean was characterized. The locus Als1 for sulfonylurea resistance was mapped and the resistant allele was characterized at the molecular level...
  86. ncbi Kinetics and mechanism of acetohydroxy acid synthase isozyme III from Escherichia coli
    N Gollop
    Department of Biology, Ben Gurion University of the Negev, Beer Sheva, Israel
    Biochemistry 28:6310-7. 1989
    Acetohydroxy acid synthase (AHAS, EC 4.1.3...
  87. ncbi Identification and sequence determination of the acetohydroxy acid isomeroreductase gene from Brevibacterium flavum MJ233
    M Inui
    Tsukuba Research Center, Mitsubishi Petrochemical Co, Ltd, Ibaraki, Japan
    DNA Seq 4:95-103. 1993
    ..We previously reported the cloning and sequencing of the acetohydroxy acid synthase (AHAS) genes from Brevibacterium flavum MJ233...
  88. pmc Regulation of Caulobacter crescentus ilvBN gene expression
    J C Tarleton
    Department of Biological Sciences, University of South Carolina, Columbia 29208
    J Bacteriol 176:3765-74. 1994
    ..crescentus to regulate gene expression, the ilvBN genes encoding the two subunits of an acetohydroxy acid synthase (AHAS) have been characterized. Analysis of the DNA sequences indicated that the C...
  89. ncbi Molecular cloning, DNA sequencing, and biochemical analyses of Escherichia coli glyoxylate carboligase. An enzyme of the acetohydroxy acid synthase-pyruvate oxidase family
    Y Y Chang
    Department of Microbiology, University of Illinois, Urbana Champaign, 61801
    J Biol Chem 268:3911-9. 1993
    ..acid residues (64,738 Da) that has a high level (30%) of sequence similarity to the acetohydroxy acid synthases (AHAS) of branched chain amino acid synthetic pathway. Significant sequence identity (26%) was also observed with E...
  90. ncbi A human homolog of bacterial acetolactate synthase genes maps within the CADASIL critical region
    A Joutel
    INSERM U25, Paris, France
    Genomics 38:192-8. 1996
    ....
  91. ncbi Homology modeling of the structure of bacterial acetohydroxy acid synthase and examination of the active site by site-directed mutagenesis
    M Ibdah
    Department of Life Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Biochemistry 35:16282-91. 1996
    Acetohydroxy acid synthase (AHAS, EC 4.1.3.18) catalyzes the thiamin pyrophosphate (TPP)-dependent decarboxylation of pyruvate and condensation of the resulting two-carbon moiety with a second alpha-keto acid...
  92. ncbi Cloning and phylogenetic analysis of the genes encoding acetohydroxyacid synthase from the archaeon Methanococcus aeolicus
    T L Bowen
    Department of Microbiology, University of Georgia, Athens 30602 2605, USA
    Gene 188:77-84. 1997
    The gene for acetohydroxyacid synthase (AHAS) was cloned from the archaeon Methanococcus aeolicus. Contrary to biochemical studies [Xing, R. and Whitman, W.B. (1994) J. Bacteriol...
  93. ncbi Biosynthesis of 2-aceto-2-hydroxy acids: acetolactate synthases and acetohydroxyacid synthases
    D Chipman
    Department of Life Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Biochim Biophys Acta 1385:401-19. 1998
    ..from pyruvate and 2-oxobutyrate, as well as of acetolactate from two molecules of pyruvate (the ALS/AHAS group)...
  94. ncbi Identification of the regulatory subunit of Arabidopsis thaliana acetohydroxyacid synthase and reconstitution with its catalytic subunit
    Y T Lee
    Centre for Protein Structure, Function and Engineering, Department of Biochemistry and Molecular Biology, University of Queensland, Brisbane QLD Australia 4072
    Biochemistry 40:6836-44. 2001
    Acetohydroxyacid synthase (EC 4.1.3.18; AHAS) catalyzes the initial step in the formation of the branched-chain amino acids...
  95. pmc A role of proton transfer in peroxidase-catalyzed process elucidated by substrates docking calculations
    J Kulys
    Department of Enzyme Chemistry, Institute of Biochemistry, Mokslininku 12, Vilnius, 2600, Lithuania
    BMC Struct Biol 1:3. 2001
    Previous kinetic investigations of fungal-peroxidase catalyzed oxidation of N-aryl hydroxamic acids (AHAs) and N-aryl-N-hydroxy urethanes (AHUs) revealed that the rate of reaction was independent of the formal redox potential of ..
  96. ncbi Binding and activation of thiamin diphosphate in acetohydroxyacid synthase
    A Bar-Ilan
    Department of Life Sciences, Ben Gurion University of the Negev, P O B 653, Beer Sheva 84105, Israel
    Biochemistry 40:11946-54. 2001
    ..b>AHAS catalyzes the condensation of the 2-carbon moiety, derived from the decarboxylation of pyruvate, with a second 2-..
  97. ncbi New directions in skin care
    C P Clark
    Clin Plast Surg 28:745-50. 2001
    Tretinoin and AHAs are dependable components of any skin-rejuvenation program. These products are well studied, and the results are predictable...
  98. ncbi Crystal structure of yeast acetohydroxyacid synthase: a target for herbicidal inhibitors
    Siew Siew Pang
    Centre for Protein Structure Function and Engineering, Department of Biochemistry and Molecular Biology, School of Molecular and Microbial Sciences, The University of Queensland, Brisbane, QLD 4072, Australia
    J Mol Biol 317:249-62. 2002
    Acetohydroxyacid synthase (AHAS; EC 4.1.3.18) catalyzes the first step in branched-chain amino acid biosynthesis...
  99. ncbi Metabonomics classifies pathways affected by bioactive compounds. Artificial neural network classification of NMR spectra of plant extracts
    Karl Heinz Ott
    BASF Agro Research, Princeton, NJ 08543, USA
    Phytochemistry 62:971-85. 2003
    ..represent various biochemical modes-of-action such as inhibition of specific enzymes (acetohydroxy acid synthase [AHAS], protoporphyrin IX oxidase [PROTOX], 5-enolpyruvylshikimate-3-phosphate synthase [EPSPS], acetyl CoA carboxylase [..
  100. ncbi External quality assessment of automated hematology analyzer performance using fresh human blood samples in Shanghai
    Hu Xiaobo
    Shanghai Centre for Clinical Laboratory, Shanghai, Peoples Republic of China
    Lab Hematol 9:175-8. 2003
    We set out to assess the performance and degree of agreement for the different automated hematology analyzers (AHAs) currently used within the Shanghai region...
  101. ncbi The crystal structures of Klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactor and with an unusual intermediate
    Siew Siew Pang
    Department of Biochemistry and Molecular Biology, The University of Queensland, Brisbane, Queensland 4072, Australia
    J Biol Chem 279:2242-53. 2004
    Acetohydroxyacid synthase (AHAS) and acetolactate synthase (ALS) are thiamine diphosphate (ThDP)-dependent enzymes that catalyze the decarboxylation of pyruvate to give a cofactor-bound hydroxyethyl group, which is transferred to a second ..

Research Grants2

  1. Structural and Functional Study of Influenza Virus Hemagglutinin
    Qinghua Wang; Fiscal Year: 2013
    ..on antibody neutralization, antigenic drift and receptor binding that differ significantly from those of AHAs. This team has most recently determined the first structures of BHA from influenza B/HongKong/8/73 strain (B/HK HA) ..
  2. TRANSLATIONAL CONTROL OF TRANSCRIPTION TERMINATION
    G Hatfield; Fiscal Year: 1990
    ..We further propose to determine the molecular mechanisms responsible for the regulation of the ilvYC gene and the valyl-tRNA synthetase gene, and the roles of the AHAS isozymes in the regulation of isoleucine-valine biosynthesis.