IL9R

Summary

Gene Symbol: IL9R
Description: interleukin 9 receptor
Alias: CD129, IL-9R, interleukin-9 receptor, IL-9 receptor
Species: human

Top Publications

  1. ncbi IL-9 pathway in asthma: new therapeutic targets for allergic inflammatory disorders
    R C Levitt
    Magainin Institute of Molecular Medicine, Magainin Pharmaceuticals, Plymouth Meeting, PA 19462, USA
    J Allergy Clin Immunol 103:S485-91. 1999
  2. pmc Induction of the IL-9 gene by HTLV-I Tax stimulates the spontaneous proliferation of primary adult T-cell leukemia cells by a paracrine mechanism
    Jing Chen
    Metabolism Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    Blood 111:5163-72. 2008
  3. doi Association between IL-1A single nucleotide polymorphisms and chronic beryllium disease and beryllium sensitization
    Erin C McCanlies
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
    J Occup Environ Med 52:680-4. 2010
  4. doi High expression of IL-9R promotes the progression of human hepatocellular carcinoma and indicates a poor clinical outcome
    Hong Jun Li
    Department of Hepatobiliary Surgery, the First People s Hospital of Hefei, Anhui 230000, P R China
    Oncol Rep 34:795-802. 2015
  5. pmc Low expression of CD39(+) /CD45RA(+) on regulatory T cells (Treg ) cells in type 1 diabetic children in contrast to high expression of CD101(+) /CD129(+) on Treg cells in children with coeliac disease
    K Akesson
    Department of Pediatrics, Ryhov County Hospital, Jonkoping, Sweden Futurum the Academy for Health and Care in Jönköping County Council, Jonkoping, Sweden
    Clin Exp Immunol 180:70-82. 2015
  6. pmc Distinct spatial relationship of the interleukin-9 receptor with interleukin-2 receptor and major histocompatibility complex glycoproteins in human T lymphoma cells
    Eniko Nizsalóczki
    Department of Biophysics and Cell Biology, Research Center for Molecular Medicine, University of Debrecen, P O B 39, 4012, Debrecen Hungary
    Chemphyschem 15:3969-78. 2014
  7. pmc GATA-3 dose-dependent checkpoints in early T cell commitment
    Deirdre D Scripture-Adams
    Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125
    J Immunol 193:3470-91. 2014
  8. doi TH9 cells that express the transcription factor PU.1 drive T cell-mediated colitis via IL-9 receptor signaling in intestinal epithelial cells
    Katharina Gerlach
    Department of Medicine 1, University of Erlangen Nuremberg, Kussmaul Campus for Medical Research, Erlangen, Germany
    Nat Immunol 15:676-86. 2014
  9. doi Clinical and cytogenomic studies in a case of infertility associated with a nonmosaic dicentric Y chromosome
    Y X Cui
    Institute of Laboratory Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China
    Andrologia 47:477-81. 2015
  10. pmc Overexpression of IL-9 receptor in diffuse large B-cell lymphoma
    Xiao Lv
    Department of Hematology, Provincial Hospital affiliated to Shandong University, Jinan, China
    Int J Clin Exp Pathol 6:911-6. 2013

Research Grants

  1. UTPAL P DAVE; Fiscal Year: 2016

Scientific Experts

  • Hiroya Kobayashi
  • A Behboudi
  • P Kauppi
  • Erik Melen
  • Jana Burkhardt
  • H Asao
  • Ziarih Hawi
  • Y Lau
  • Frederic F Little
  • UTPAL P DAVE
  • Jean Christophe Renauld
  • Laurent Knoops
  • Tekla Hornakova
  • Y X Cui
  • K Akesson
  • Hong Jun Li
  • Katharina Gerlach
  • Deirdre D Scripture-Adams
  • Eniko Nizsalóczki
  • Pingxin Li
  • Sijie Sun
  • Xiao Lv
  • Rahul Purwar
  • Yi Shang
  • Thomas A Waldmann
  • Jung Hyun Namkung
  • Uppala Ratnamala
  • Carolyn K Goldman
  • Heather Osterfeld
  • Erin C McCanlies
  • Stephane Dragon
  • D Sliva
  • Yohan Royer
  • Stefan N Constantinescu
  • Jing Chen
  • Yaniv Malka
  • Lama M Fawaz
  • Qutayba Hamid
  • A Ciccodicola
  • J C Renauld
  • Fadi J Charchar
  • Y A Hu
  • T F Li
  • Jun Huang
  • Rui Ding
  • M Faresjo
  • X Y Xia
  • Long Zi Liu
  • Kang Song
  • Jun Zhang
  • N Li
  • W P Wang
  • Q Yao
  • A Ryden
  • Zhong Tong
  • W W Li
  • A Tompa
  • Q Y Wu
  • Qi man Sun
  • C Zhang
  • Cheng hong Wang
  • Andrea Bodnar
  • Akihiro Tsukadaira
  • Alexej Nikolaev
  • Markus F Neurath
  • Jingli A Zhang
  • Andrew N J McKenzie
  • Alexandra M Arias
  • Long Li
  • Robert R Butler
  • Frank Rosenbauer
  • Sandor Damjanovich
  • Stefan Wirtz
  • István Csomós
  • Ellen V Rothenberg
  • Michael Vieth
  • Peter Nagy
  • Raja Atreya
  • M D'ESPOSITO
  • Koorosh J Elihu
  • Shuyang Qin
  • György Vámosi
  • Stefanie Steiner
  • Ameya Champhekar
  • Hans Anton Lehr
  • Sagar S Damle
  • Heike Dornhoff
  • Masao Toda
  • László Mátyus
  • Ari Waisman

Detail Information

Publications48

  1. ncbi IL-9 pathway in asthma: new therapeutic targets for allergic inflammatory disorders
    R C Levitt
    Magainin Institute of Molecular Medicine, Magainin Pharmaceuticals, Plymouth Meeting, PA 19462, USA
    J Allergy Clin Immunol 103:S485-91. 1999
    ..Because of its importance in human health, additional research and alternative therapeutic strategies are justified to create more effective treatments for this debilitating disease...
  2. pmc Induction of the IL-9 gene by HTLV-I Tax stimulates the spontaneous proliferation of primary adult T-cell leukemia cells by a paracrine mechanism
    Jing Chen
    Metabolism Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    Blood 111:5163-72. 2008
    ..In summary, these data support a role for IL-9 and its receptor in ATL by a paracrine mechanism...
  3. doi Association between IL-1A single nucleotide polymorphisms and chronic beryllium disease and beryllium sensitization
    Erin C McCanlies
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
    J Occup Environ Med 52:680-4. 2010
    ..To determine if single nucleotide polymorphisms (SNPs) in interleukin (IL) IL-1A, IL-1B, IL-1RN, IL-2, IL-9, and IL-9R were associated with chronic beryllium disease (CBD) and beryllium sensitization (BeS)...
  4. doi High expression of IL-9R promotes the progression of human hepatocellular carcinoma and indicates a poor clinical outcome
    Hong Jun Li
    Department of Hepatobiliary Surgery, the First People s Hospital of Hefei, Anhui 230000, P R China
    Oncol Rep 34:795-802. 2015
    ..018). The findings indicated that IL-9R was constitutively expressed and exerted a tumor-promoting effect in HCC, whose expression level may be a useful biomarker of tumor invasiveness and patient clinical outcome. ..
  5. pmc Low expression of CD39(+) /CD45RA(+) on regulatory T cells (Treg ) cells in type 1 diabetic children in contrast to high expression of CD101(+) /CD129(+) on Treg cells in children with coeliac disease
    K Akesson
    Department of Pediatrics, Ryhov County Hospital, Jonkoping, Sweden Futurum the Academy for Health and Care in Jönköping County Council, Jonkoping, Sweden
    Clin Exp Immunol 180:70-82. 2015
    ..CCR7(-) ) and Treg (CD4(+) CD25(+) FOXP3(+) CD127(-) ) cells, and their expression of CD39, CD45RA, CD101 and CD129, were studied by flow cytometry in T1D and/or coeliac disease children or without any of these diseases (reference ..
  6. pmc Distinct spatial relationship of the interleukin-9 receptor with interleukin-2 receptor and major histocompatibility complex glycoproteins in human T lymphoma cells
    Eniko Nizsalóczki
    Department of Biophysics and Cell Biology, Research Center for Molecular Medicine, University of Debrecen, P O B 39, 4012, Debrecen Hungary
    Chemphyschem 15:3969-78. 2014
    ..Our data indicate that co-compartmentalization with MHC glycoproteins is a general property of γ(c) receptors. Distribution of receptor chains between different membrane domains may regulate their function...
  7. pmc GATA-3 dose-dependent checkpoints in early T cell commitment
    Deirdre D Scripture-Adams
    Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125
    J Immunol 193:3470-91. 2014
    ..1) and Bcl11a, and downregulated genes, including Cpa3, Ets1, Zfpm1, Bcl11b, Il9r, and Il17rb with gene-specific kinetics and dose dependencies...
  8. doi TH9 cells that express the transcription factor PU.1 drive T cell-mediated colitis via IL-9 receptor signaling in intestinal epithelial cells
    Katharina Gerlach
    Department of Medicine 1, University of Erlangen Nuremberg, Kussmaul Campus for Medical Research, Erlangen, Germany
    Nat Immunol 15:676-86. 2014
    ....
  9. doi Clinical and cytogenomic studies in a case of infertility associated with a nonmosaic dicentric Y chromosome
    Y X Cui
    Institute of Laboratory Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China
    Andrologia 47:477-81. 2015
    ..32→Yqter).ish (DYZ3++, SRY++, SHOX-). array (PLCXD1→SHOX) ×1,(SRY →GOLGA2P3Y)×2, (DHRSX→ ASMT, SPRY3 →IL9R)×3. The rearrangement Y chromosome is de novo. This is the first case reported with a nonmosaic 46,X, i (Y) (p11...
  10. pmc Overexpression of IL-9 receptor in diffuse large B-cell lymphoma
    Xiao Lv
    Department of Hematology, Provincial Hospital affiliated to Shandong University, Jinan, China
    Int J Clin Exp Pathol 6:911-6. 2013
    ..Our findings suggest that overexpression of IL-9R may contribute to the pathogenesis of DLBCL and is associated with some adverse prognostic parameters...
  11. doi Interleukin-9 receptor gene is transcriptionally regulated by nucleolin in T-cell lymphoma cells
    Yi Shang
    Experimental Radiobiology for Children s Health Research Group, Research Center for Radiation Protection, National Institute of Radiological Sciences, Inage Ku, Chiba, Japan
    Mol Carcinog 51:619-27. 2012
    ..The molecular mechanism that regulates transcription of the IL-9R gene (Il9r) during leukemogenesis is, however, not well understood...
  12. doi A naturally processed HLA-DR-bound peptide from the IL-9 receptor alpha of HTLV-1-transformed T cells serves as a T helper epitope
    Hiroya Kobayashi
    Department of Pathology, Asahikawa Medical University, midorigaoka higashi 2 1 1, Asahikawa, 078 8510, Japan
    Cancer Immunol Immunother 61:2215-25. 2012
    ....
  13. pmc Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells
    Rahul Purwar
    Department of Dermatology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 18:1248-53. 2012
    ..IL-9-blocking antibodies reversed this tumor growth inhibition and enhanced tumor growth in wild-type (WT) mice. Il9r(-/-) mice showed accelerated tumor growth, and administration of recombinant IL-9 (rIL-9) to tumor-bearing WT and ..
  14. pmc Expression of plasma membrane receptor genes during megakaryocyte development
    Sijie Sun
    Department of Bioengineering, 2Puget Sound Blood Center, Seattle, Washington, USA
    Physiol Genomics 45:217-27. 2013
    ..These genes included: interleukin-9 receptor (IL9R), transforming growth factor, β receptor II (TGFBR2), interleukin-4 receptor (IL4R), colony stimulating factor-2 ..
  15. pmc A fusion cytokine coupling GMCSF to IL9 induces heterologous receptor clustering and STAT1 hyperactivation through JAK2 promiscuity
    Pingxin Li
    Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia, United States of America
    PLoS ONE 8:e69405. 2013
    ..that it chaperones co-clustering of the functionally unrelated GMCSF receptor (GMCSFR) and IL9 receptor (IL9R) on cell surface of target cells...
  16. ncbi IL-9 and its receptor: from signal transduction to tumorigenesis
    Laurent Knoops
    Ludwig Institute for Cancer Research and Experimental Medicine Unit, Universite de Louvain, UCL 74 59, Avenue Hippodrome 74, B 1200 Brussels, Belgium
    Growth Factors 22:207-15. 2004
    ..Moreover, in vitro, dysregulated IL-9 response can lead to autonomous cell growth and malignant transformation of lymphoid cells associated with constitutive activation of the Jak/STAT pathway...
  17. doi An association between IL-9 and IL-9 receptor gene polymorphisms and atopic dermatitis in a Korean population
    Jung Hyun Namkung
    Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    J Dermatol Sci 62:16-21. 2011
    ..Although studies performed on transgenic and knockout mice have shown conflicting results, no evidence of skin changes has ever been reported in these animals...
  18. pmc Refinement of the X-linked nonsyndromic high-grade myopia locus MYP1 on Xq28 and exclusion of 13 known positional candidate genes by direct sequencing
    Uppala Ratnamala
    Department of Pharmacology, Creighton University, Omaha, Nebraska, USA
    Invest Ophthalmol Vis Sci 52:6814-9. 2011
    ..It can occur as an isolated genetic condition or be associated with other anomalies and/or syndromes. Seventeen myopia loci have been identified on various chromosomes; however, no specific gene mutations have yet been identified...
  19. pmc Differential roles for the IL-9/IL-9 receptor alpha-chain pathway in systemic and oral antigen-induced anaphylaxis
    Heather Osterfeld
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    J Allergy Clin Immunol 125:469-476.e2. 2010
    ..The cytokine IL-9 has been implicated in allergic reactions, including food allergy, but its contribution to parenteral versus oral antigen-induced anaphylaxis remains unclear...
  20. doi Association of the X-chromosomal genes TIMP1 and IL9R with rheumatoid arthritis
    Jana Burkhardt
    Institute of Clinical Immunology and Transfusion Medicine Center for Biotechnology and Biomedicine BBZ, Leipzig, Germany
    J Rheumatol 36:2149-57. 2009
    ..Rheumatoid arthritis (RA) is an inflammatory joint disease with features of an autoimmune disease with female predominance. Candidate genes located on the X-chromosome were selected for a family trio-based association study...
  21. doi T(H)2 cytokines modulate the IL-9R expression on human neutrophils
    Stephane Dragon
    Department of Immunology and the CIHR National Training Program in Allergy and Asthma, University of Manitoba, Winnipeg, Mannitoba, Canada
    Biochem Biophys Res Commun 384:167-72. 2009
    ..Collectively, our results reveal a regulatory function for IFN-gamma and IL-10 on modulating the inducible IL-9Ralpha expression levels on peripheral blood neutrophils by T(H)2 cytokines...
  22. pmc Acute lymphoblastic leukemia-associated JAK1 mutants activate the Janus kinase/STAT pathway via interleukin-9 receptor alpha homodimers
    Tekla Hornakova
    Ludwig Institute for Cancer Research, Brussels Branch and de Duve Institute, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    J Biol Chem 284:6773-81. 2009
    ..Similar results were observed with IL-2Rbeta. Taken together, our results show that IL-9Ralpha and IL-2Rbeta homodimers efficiently mediate constitutive activation of ALL-associated JAK1 mutants...
  23. pmc Ligand-independent homomeric and heteromeric complexes between interleukin-2 or -9 receptor subunits and the gamma chain
    Yaniv Malka
    Department of Neurobiology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    J Biol Chem 283:33569-77. 2008
    ....
  24. ncbi Expression of IL-9 receptor alpha chain on human germinal center B cells modulates IgE secretion
    Lama M Fawaz
    Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada
    J Allergy Clin Immunol 120:1208-15. 2007
    ..IL-9 has been shown to affect the differentiation pathway of different cell types. However, its potential role in the maturation pathway of antigen-driven B-cell differentiation and its functional effects remain unknown...
  25. ncbi Interaction between variants in the interleukin-4 receptor alpha and interleukin-9 receptor genes in childhood wheezing: evidence from a birth cohort study
    E Melen
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Clin Exp Allergy 36:1391-8. 2006
    ..Such interactions have been proposed to explain partly the difficulties in replicating association studies...
  26. ncbi Differentially regulated and evolved genes in the fully sequenced Xq/Yq pseudoautosomal region
    A Ciccodicola
    International Institute of Genetics and Biophysics, CNR, Via Marconi 10, 80125 Naples, Italy
    Hum Mol Genet 9:395-401. 2000
    ..The GC-rich distal 35 kb, added in stages and much later in evolution, contains the X/Y expressed gene IL9R and a novel gene, CXYorf1, only 5 kb from the Xq telomere...
  27. ncbi Sharing of the IL-2 receptor gamma chain with the functional IL-9 receptor complex
    Y Kimura
    Department of Microbiology, Tohoku University School of Medicine, Sendai, Japan
    Int Immunol 7:115-20. 1995
    ..These results demonstrate that the gamma c chain is included in the functional receptor complex for IL-9, which was initially characterized as a T cell growth factor and is essential for IL-9-dependent growth signal transduction...
  28. ncbi Isolation and characterization of the human interleukin-9 receptor gene
    M S Chang
    Department of Developmental Biology, Amgen Inc Thousand Oaks, CA 91361
    Blood 83:3199-205. 1994
    ....
  29. ncbi The IL-9 receptor gene (IL9R): genomic structure, chromosomal localization in the pseudoautosomal region of the long arm of the sex chromosomes, and identification of IL9R pseudogenes at 9qter, 10pter, 16pter, and 18pter
    A Kermouni
    Ludwig Institute for Cancer Research, Brussels Branch, Belgium
    Genomics 29:371-82. 1995
    Cosmids containing the human IL-9 receptor (R) gene (IL9R) have been isolated from a genomic library using the IL9R cDNA as a probe. We have shown that the human IL9R cDNA as a probe...
  30. pmc A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9
    J B Demoulin
    Brussels Branch, Ludwig Institute for Cancer Research, Brussels, Belgium
    Mol Cell Biol 16:4710-6. 1996
    ..Taken together, these data indicate that a single tyrosine of the IL-9 receptor, required for activation of three different STAT proteins, is necessary for distinct activities of this cytokine, including proliferative responses...
  31. ncbi The IL-9 receptor gene, located in the Xq/Yq pseudoautosomal region, has an autosomal origin, escapes X inactivation and is expressed from the Y
    J R Vermeesch
    Center for Human Genetics, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Belgium
    Hum Mol Genet 6:1-8. 1997
    ..We show that the interleukin-9 (IL-9) receptor gene (IL9R), which is located within the human Xq/Yq homology region, maps to the murine chromosome 11...
  32. ncbi Differential expression pattern of XqPAR-linked genes SYBL1 and IL9R correlates with the structure and evolution of the region
    M D'ESPOSITO
    International Institute of Genetics and Biophysics, CNR, Naples, Italy
    Hum Mol Genet 6:1917-23. 1997
    The recently discovered second pseudoautosomal region (XqPAR) contains at least two genes, IL9R and SYBL1...
  33. ncbi Heteromerization of the gammac chain with the interleukin-9 receptor alpha subunit leads to STAT activation and prevention of apoptosis
    J H Bauer
    Institute for Biochemistry, Free University Berlin, 14195 Berlin, Germany
    J Biol Chem 273:9255-60. 1998
    ..Nonetheless, these T cells are efficiently protected from dexamethasone-induced apoptosis. These results further define the molecular architecture of the IL-9R and its specific connections to various biologic responses...
  34. ncbi Tip60 interacts with human interleukin-9 receptor alpha-chain
    D Sliva
    Department of Medicine Hematology Oncology, Indiana University School of Medicine, and Indiana Cancer Research Institute, 1044 W Walnut Street, R4 272, Indianapolis, Indiana 46202, USA
    Biochem Biophys Res Commun 263:149-55. 1999
    ..Our results therefore suggest that Tip60 may act as a cofactor of Stat3 or as an adaptor protein for molecules that are important for IL-9 signaling...
  35. ncbi Pseudoautosomal gene: possible association with bipolar males but not with schizophrenia
    Z Hawi
    Department of Psychiatry and Genetics, Trinity College, Dublin, Ireland
    Psychiatr Genet 9:129-34. 1999
    ..In this investigation, we analysed a polymorphic CAG repeat in the interleukin receptor gene (IL9R), mapped to the pseudoautosomal region Xq28 and Yq21 (a candidate region for schizophrenia and affective disorder)...
  36. pmc 14-3-3zeta interacts with the alpha-chain of human interleukin 9 receptor
    D Sliva
    Department of Medicine Hematology Oncology, Indiana University School of Medicine, and Indiana Cancer Research Institute, 1044 W Walnut Street, R4 272, Indianapolis, IN 46202, USA
    Biochem J 345:741-7. 2000
    ..This is the first demonstration that 14-3-3 can interact with a non-tyrosine kinase receptor. The interaction between 14-3-3 and IL-9Ralpha but not IL-4Ralpha also suggests a potential role for 14-3-3 in determining cytokine specificity...
  37. pmc Expression cloning of the murine and human interleukin 9 receptor cDNAs
    J C Renauld
    Ludwig Institute for Cancer Research, University of Louvain, Brussels, Belgium
    Proc Natl Acad Sci U S A 89:5690-4. 1992
    ..Sequence analysis revealed that the IL-9 receptor belongs to the recently described hematopoietin receptor super-family and is expressed in membrane-bound and soluble forms...
  38. ncbi Signals from the IL-9 receptor are critical for the early stages of human intrathymic T cell development
    M De Smedt
    Department of Clinical Chemistry, University of Ghent, University Hospital of Ghent, Ghent, Belgium
    J Immunol 164:1761-7. 2000
    ..Addition of IL-9 to the FTOC resulted in an increase in cell number, without disturbing the frequencies of the different subsets. These data suggest that IL-9Ralpha signaling is critical in early T lymphoid development...
  39. ncbi Expression analysis of thirty one Y chromosome genes in human prostate cancer
    Y F Lau
    Division of Cell and Developmental Genetics, Department of Medicine, VA Medical Center, 111C5, University of California, San Francisco, San Francisco, California 94121, USA
    Mol Carcinog 27:308-21. 2000
    ..Androgen stimulation of the LNCaP cells resulted in up-regulation of PGPL, CSFR2A, IL3RA, TSPY, and IL9R and down regulation of SRY, ZFY, and DFFRY...
  40. ncbi The IL9R region contribution in asthma is supported by genetic association in an isolated population
    P Kauppi
    Department of Medicine, Helsinki University Central Hospital, Finland
    Eur J Hum Genet 8:788-92. 2000
    ..5q cytokine cluster did not support a genetic role for the IL9 gene, we became interested in the IL9 receptor gene (IL9R) in the pseudoautosomal region...
  41. ncbi Functional expression of IL-9 receptor by human neutrophils from asthmatic donors: role in IL-8 release
    S Abdelilah
    Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada
    J Immunol 166:2768-74. 2001
    ..Taken together, these findings suggest a novel role for PMNs in allergic disease through the expression and activation of the IL-9R...
  42. ncbi Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex
    H Asao
    Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Immunol 167:1-5. 2001
    ..The chemical cross-linking study reveals the direct binding of IL-21 to the gamma(c). These data clearly demonstrate that the gamma(c) is an indispensable subunit of the functional IL-21R complex...
  43. ncbi Il-9 stimulates release of chemotactic factors from human bronchial epithelial cells
    F F Little
    The Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Am J Respir Cell Mol Biol 25:347-52. 2001
    ..We conclude that IL-9 is a stimulus for airway epithelial cell release of T-cell chemoattractant factors, which in turn may modulate the immune response in allergic airway inflammation...
  44. ncbi A calcium-activated chloride channel (HCLCA1) is strongly related to IL-9 expression and mucus production in bronchial epithelium of patients with asthma
    Masao Toda
    Meakins Christie Laboratories, Montreal, Quebec, Canada
    J Allergy Clin Immunol 109:246-50. 2002
    ..Recently, a calcium-activated chloride channel, HCLCA1, was described that is upregulated by IL-9 and thought to regulate the expression of soluble gel-forming mucins, such as MUC5A/C, a critical component of mucus in the airways...
  45. ncbi Human bronchial epithelium expresses interleukin-9 receptors and releases neutrophil chemotactic factor
    Akihiro Tsukadaira
    First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    Exp Lung Res 28:123-39. 2002
    ..The components of the IL-9 receptor, consisting of IL-9 receptor alpha (CD129) and IL-2 receptory ((1)132), were expressed on BEAS-2B cells as determined by RT-PCR and flow cytometry...
  46. ncbi Detailed chromosomal and radiation hybrid mapping in the proximal part of rat Chromosome 10 and gene order comparison with mouse and human
    Afrouz Behboudi
    Department of Cell and Molecular Biology Genetics, Lundberg Laboratory, Goteborg University, Box 462, Sweden
    Mamm Genome 13:302-9. 2002
    ..The regional localization of 14 genes, most of them cancer-related ( Grin2a, Gspt1, Crebbp, Gfer, Tsc2, Tpsb1, Il9r, Il4, Irf1, Csf2, Sparc, Tp53, Thra1, Gh1), and of five microsatellite markers ( D10Mit10, D10Rat42, D10Rat50, ..
  47. pmc Complex events in the evolution of the human pseudoautosomal region 2 (PAR2)
    Fadi J Charchar
    Department of Genetics, La Trobe University, Bundoora, Victoria 3086, Australia
    Genome Res 13:281-6. 2003
    ..in primates and also in mouse, but autosomal in wallaby, suggesting a later addition 70-130 million years ago, and IL9R was on the X only in primate, suggesting addition 60-70 million years ago...
  48. pmc Sex specific protective effects of interleukin-9 receptor haplotypes on childhood wheezing and sensitisation
    E Melen
    J Med Genet 41:e123. 2004

Research Grants1

  1. UTPAL P DAVE; Fiscal Year: 2016
    ..tyrosine kinase that binds with IL2RG to transduce signals from multiple cytokine receptors (IL2R, IL4R, IL7R, IL9R, IL15R, and IL21R) upon ligand binding...