Genomes and Genes
Gene Symbol: IL7R
Description: interleukin 7 receptor
Alias: CD127, CDW127, IL-7R-alpha, IL7RA, ILRA, interleukin-7 receptor subunit alpha, CD127 antigen, IL-7 receptor subunit alpha, IL-7R subunit alpha, interleukin 7 receptor alpha chain, interleukin 7 receptor isoform H5-6
Publications210 found, 100 shown here
- Upregulation of interleukin 7 receptor alpha and programmed death 1 marks an epitope-specific CD8+ T-cell response that disappears following primary Epstein-Barr virus infectionDelphine Sauce
CRUK Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
J Virol 83:9068-78. 2009..but showed unique temporal changes in two markers of T-cell fate, interleukin 7 receptor alpha (IL-7Ralpha; CD127) and programmed death 1 (PD-1)...
- Concentration and activity of the soluble form of the interleukin-7 receptor α in type 1 diabetes identifies an interplay between hyperglycemia and immune functionPaolo Monti
San Raffaele Diabetes Research Institute, San Raffaele Scientific Institute, Milan, Italy
Diabetes 62:2500-8. 2013..The findings indicate that genetic, immunologic, and metabolic factors contribute to a dysregulation of the IL-7/IL-7 receptor pathway in T1D and identify a novel hyperglycemia-mediated interference of immune regulatory networks. ..
- HIV regulation of the IL-7R: a viral mechanism for enhancing HIV-1 replication in human macrophages in vitroMingjie Zhang
Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, FDA, 1401 Rockville Pike, Rockville, MD 20852 1448, USA
J Leukoc Biol 79:1328-38. 2006..The results suggest that the effects of IL-7 on HIV replication in MDM should be considered when analyzing and designing clinical trials involving treatment of patients with IL-7 or Tat vaccines...
- Interleukin (IL)-7 induces rapid activation of Pyk2, which is bound to Janus kinase 1 and IL-7RalphaN Benbernou
Intramural Research Support Program, SAIC Frederick, NCI Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
J Biol Chem 275:7060-5. 2000..These data support a role for Pyk2 in coupling Jak signaling to the trophic response...
- Organization of the murine and human interleukin-7 receptor genes: two mRNAs generated by differential splicing and presence of a type I-interferon-inducible promoterC M Pleiman
Department of Molecular Biology, Immunex Corporation, Seattle, Washington 98101
Mol Cell Biol 11:3052-9. 1991..Comparison of the murine and human IL-7R exon/intron boundaries with those of other hematopoietin receptor superfamily members whose exon/intron boundaries are also known reveals a conserved evolutionary structure...
- Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiencyA Puel
Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1674, USA
Nat Genet 20:394-7. 1998..Some SCID patients lack T cells but retain NK cells. Given diminished T-cell development in Il7- or Il7r-deficient mice and that Il/7r-deficient mice have NK cells, we hypothesized that T(-)B(+)NK(+) SCID might result ..
- A partial deficiency of interleukin-7R alpha is sufficient to abrogate T-cell development and cause severe combined immunodeficiencyC M Roifman
Division of Immunology Allergy, Department of Paediatrics, The Hospital for Sick Children, Toronto, Canada
Blood 96:2803-7. 2000..This underscores the critical role of IL-7R alpha chain in the differentiation of T cells. (Blood. 2000;96:2803-2807)..
- Two genes encoding immune-regulatory molecules (LAG3 and IL7R) confer susceptibility to multiple sclerosisZ Zhang
Department of Molecular Sciences, Section for Genetics and Bioinformatics, AstraZeneca R and D Sodertalje, Sodertalje, Sweden
Genes Immun 6:145-52. 2005..05) associated SNPs--conferred susceptibility to MS: LAG3 on chromosome 12p13, and IL7R on 5p13. LAG3 inhibits activated T cells, while IL7R is necessary for the maturation of T and B cells...
- Loss of CD127 expression defines an expansion of effector CD8+ T cells in HIV-infected individualsMirko Paiardini
Department of Medicine, and Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA
J Immunol 174:2900-9. 2005..In this study we show that in HIV-infected individuals the loss of IL-7R (CD127) expression defines the expansion of a subset of CD8(+) T cells, specific for HIV as well as other Ags, that show ..
- Cutting edge: emergence of CD127high functionally competent memory T cells is compromised by high viral loads and inadequate T cell helpMichael J Fuller
Department of Microbiology, University of Alabama, Birmingham, AL 35294, USA
J Immunol 174:5926-30. 2005..report we have inspected whether difficulties in controlling viral infections negatively impacts the generation of CD127(high) memory T cells...
- Altered IL-7Ralpha expression with aging and the potential implications of IL-7 therapy on CD8+ T-cell immune responsesHang Rae Kim
Section of Rheumatology, Department of Internal Medicine, TAC S541C, Yale School of Medicine, PO Box 208031, New Haven, CT 06520
Blood 107:2855-62. 2006....
- Genetic polymorphisms in the genes encoding human interleukin-7 receptor-alpha: prognostic significance in allogeneic stem cell transplantationZ Shamim
The Tissue Typing Laboratory, Rigshospitalet, Copenhagen, Denmark
Bone Marrow Transplant 37:485-91. 2006..These findings suggest that the IL-7Ralpha polymorphisms may be of importance for treatment-related mortality after SCT...
- Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cellsNabila Seddiki
Centenary Institute of Cancer Medicine and Cell Biology, Faculty of Medicine, University of Sydney, Newtown, NSW 2042, Australia
J Exp Med 203:1693-700. 2006..Here, we show that expression of CD127, the alpha chain of the interleukin-7 receptor, allows an unambiguous flow cytometry-based distinction to be made ..
- CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cellsWeihong Liu
UCSF Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
J Exp Med 203:1701-11. 2006..We found that the IL-7 receptor (CD127) is down-regulated on a subset of CD4(+) T cells in peripheral blood...
- Notch1 and IL-7 receptor interplay maintains proliferation of human thymic progenitors while suppressing non-T cell fatesMarina García-Peydró
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Madrid, Spain
J Immunol 177:3711-20. 2006..These data provide insight into a mechanism of Notch-regulated amplification of the intrathymic pool of early human T cell progenitors...
- Human CD4+ regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cellsDENNIS J HARTIGAN-O'CONNOR
Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
J Immunol Methods 319:41-52. 2007..T-regs, but consistent and specific discrimination of functional T-regs was only made possible by focus on CD127, the alpha chain of the IL-7 receptor...
- Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetesJohn A Todd
Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 0XY, UK
Nat Genet 39:857-64. 2007..Several regions, including 18q22 and 18p11, showed association with autoimmune thyroid disease. This study increases the number of T1D loci with compelling evidence from six to at least ten...
- Risk alleles for multiple sclerosis identified by a genomewide studyDavid A Hafler
Division of Molecular Immunology, Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, and Harvard Medical School, Boston, USA
N Engl J Med 357:851-62. 2007..Multiple sclerosis has a clinically significant heritable component. We conducted a genomewide association study to identify alleles associated with the risk of multiple sclerosis...
- Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosisFrida Lundmark
Division of Neurology, Department of Clinical Neuroscience, Karolinska Institutet at Karolinska University Hospital Huddinge, SE 141 86 Stockholm, Sweden
Nat Genet 39:1108-13. 2007..Here, we report compelling evidence that polymorphisms in IL7R, which encodes the interleukin 7 receptor alpha chain (IL7Ralpha), indeed contribute to the non-HLA genetic risk in multiple sclerosis, demonstrating a ..
- Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosisSimon G Gregory
Center for Human Genetics, Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA
Nat Genet 39:1083-91. 2007..We describe allelic association of a polymorphism in the gene encoding the interleukin 7 receptor alpha chain (IL7R) as a significant risk factor for multiple sclerosis in four independent family-based or case-..
- IL-7 decreases IL-7 receptor alpha (CD127) expression and induces the shedding of CD127 by human CD8+ T cellsAgatha Vranjkovic
Ottawa Health Research Institute, Ottawa, ON, Canada
Int Immunol 19:1329-39. 2007IL-7 receptor alpha (CD127) signaling is essential for T-cell development and regulation of naive and memory T-cell homeostasis...
- Study of the association between the CAPSL-IL7R locus and type 1 diabetesJ L Santiago
Department of Immunology, Hospital Clinico San Carlos, Martin Lagos s n, 28040 Madrid, Spain
Diabetologia 51:1653-8. 2008..in a large white population and corroborated in a genome-wide analysis, which also found an association with IL7R, which is located adjacent to CAPSL...
- Down-regulation of interleukin-7 receptor (CD127) in HIV infection is associated with T cell activation and is a main factor influencing restoration of CD4(+) cells after antiretroviral therapyJose M Benito
Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain
J Infect Dis 198:1466-73. 2008..Recently, attention has been paid to interleukin (IL)-7 and its receptor (CD127)...
- IL-2 receptor gamma chain cytokines differentially regulate human CD8+CD127+ and CD8+CD127- T cell division and susceptibility to apoptosisAngela M Crawley
Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada
Int Immunol 21:29-42. 2009Expression of IL-7 receptor alpha (CD127) is associated with naive and memory (i.e. non-effector) CD8+ T cell phenotypes. Effector CD8+ T cells are predominantly CD127- and most die by apoptosis...
- Structural and biophysical studies of the human IL-7/IL-7Ralpha complexCraig A McElroy
Department of Molecular and Cellular Biochemistry, College of Medicine, Comprehensive Cancer Center, Ohio State University, 467 Hamilton Hall, 1645 Neil Avenue, Columbus, OH 43210, USA
Structure 17:54-65. 2009..The IL-7/IL-7Ralpha structures provide a window into the molecular recognition events of the IL-7 signaling cascade and provide sites to target for designing new therapeutics to treat IL-7-related diseases...
- IL-7 and the HIV Tat protein act synergistically to down-regulate CD127 expression on CD8 T cellsElliott Faller
Ottawa Health Research Institute, 501 Smyth Road, Ottawa, Ontario, Canada
Int Immunol 21:203-16. 2009..We have previously shown decreased expression of the IL-7 receptor alpha-chain (CD127) on CD8 T cells from HIV-infected patients with active viral replication...
- Interleukin-7 receptor signaling is deficient in CD4+ T cells from HIV-infected persons and is inversely associated with agingDouglas A Bazdar
Division of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University, and University Hospitals, Cleveland, Ohio 44106, USA
J Infect Dis 199:1019-28. 2009..Although CD127 expression was diminished for T cells from HIV-infected persons, it was not directly related to IL-7 receptor ..
- Interleukin-7 receptor-alpha gene polymorphisms in bone marrow transplant recipientsNegar Azarpira
Organ Transplant Research Center, Shiraz University of Medical Sciences, Zand Street, Nemazi Hospital, Shiraz, Iran
Mol Biol Rep 37:27-31. 2010..Its effect is mediated via interleukin 7 receptor (IL7R)...
- Identification and biochemical characterization of human plasma soluble IL-7R: lower concentrations in HIV-1-infected patientsThierry Rose
Institut Pasteur, Unité d Immunogénétique Cellulaire, Paris France
J Immunol 182:7389-97. 2009..0014) 2-fold decrease in plasma sIL-7Ralpha levels compared with those in control healthy individuals. Plasma IL-7 and sIL-7Ralpha levels did not show any obvious relationship...
- Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility lociPhilip L De Jager
Division of Molecular Immunology, Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
Nat Genet 41:776-82. 2009....
- Elevated expression of interleukin-7 receptor in inflamed joints mediates interleukin-7-induced immune activation in rheumatoid arthritisSarita A Y Hartgring
Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
Arthritis Rheum 60:2595-605. 2009..To evaluate the expression and functional ability of the high-affinity interleukin-7 receptor (IL-7Ralpha) in patients with rheumatoid arthritis (RA)...
- IL7RA polymorphisms and chronic inflammatory arthropathiesC O'Doherty
School of Pharmacy and Medical Sciences, City East Campus, University of South Australia, Adelaide, Australia
Tissue Antigens 74:429-31. 2009..C allele of a single nucleotide polymorphism (SNP), rs6897932, located in the interleukin-7 receptor alpha chain (IL7RA) was recently found to be associated with multiple sclerosis and Type I diabetes...
- Replication of CD58 and CLEC16A as genome-wide significant risk genes for multiple sclerosisIlse A Hoppenbrouwers
Department of Neurology, MS Centre ErasMS, Erasmus MC, Rotterdam, The Netherlands
J Hum Genet 54:676-80. 2009..Of the 17 IMSGC SNPs, five SNPs showed genome-wide significant association with MS: HLA-DRA (P=8E-124), IL7R (P=6E-09), IL2RA (P=1E-11), CD58 (P=4E-09) and CLEC16A (P=3E-12)...
- Multiple sclerosis susceptibility alleles in African AmericansB A Johnson
Department of Neurology, University of California, San Francisco, CA 94143, USA
Genes Immun 11:343-50. 2010..None of the tested variants showed results that were statistically inconsistent with the effects established in whites. The results are consistent with shared disease genetic mechanisms among individuals of European and African ancestry...
- Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk scorePhilip L De Jager
Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women s Hospital, Boston, MA 02115, USA
Lancet Neurol 8:1111-9. 2009..We investigated the usefulness of an aggregate measure of risk of MS that is based on genetic susceptibility loci. We also assessed the added effect of environmental risk factors that are associated with susceptibility for MS...
- Functionally significant differences in expression of disease-associated IL-7 receptor alpha haplotypes in CD4 T cells and dendritic cellsEdwin Hoe
Westmead Millennium Institute, University of Sydney, Westmead, New South Wales, Australia
J Immunol 184:2512-7. 2010..Because signaling through IL-7Ralpha controls T cell regulation, this haplotype difference is likely to affect the immunophenotype and disease pathogenesis...
- IL-7 induces rapid clathrin-mediated internalization and JAK3-dependent degradation of IL-7Ralpha in T cellsCatarina M Henriques
Cancer Biology Unit, Instituto de Medicina Molecular, Lisbon University Medical School, Lisbon, Portugal
Blood 115:3269-77. 2010..It is well established that IL-7 promotes the transcriptional down-regulation of IL7RA, leading to decreased IL-7Ralpha surface expression...
- Soluble IL-7R alpha (sCD127) inhibits IL-7 activity and is increased in HIV infectionAngela M Crawley
Ottawa Hospital Research Institute, ON, Canada
J Immunol 184:4679-87. 2010Soluble CD127 (sCD127) appears to play an important role in the immunopathogenesis of several chronic infections, multiple sclerosis, and various cancers...
- Soluble HIV Tat protein removes the IL-7 receptor alpha-chain from the surface of resting CD8 T cells and targets it for degradationElliott M Faller
Ottawa Hospital Research Institute
J Immunol 185:2854-66. 2010..We have previously shown decreased expression of the IL-7R alpha-chain (CD127) on CD8 T cells in HIV(+) patients and that this downregulation is mediated at least in part by the HIV Tat ..
- Biological determinants of immune reconstitution in HIV-infected patients receiving antiretroviral therapy: the role of interleukin 7 and interleukin 7 receptor α and microbial translocationReena Rajasuriar
Department of Medicine, Monash University, Burnet Institute, University of Melbourne, Melbourne, Australia
J Infect Dis 202:1254-64. 2010..We hypothesized that residual immune activation and polymorphisms in the interleukin 7 (IL-7) receptor α (IL-7Rα) gene were important for immune recovery...
- Gain-of-function mutations in interleukin-7 receptor-α (IL7R) in childhood acute lymphoblastic leukemiasChen Shochat
Childhood Leukemia Research Institute and Department of Pediatric Hemato Oncology, Sheba Medical Center, Tel Hashomer, Ramat Gan 52621, Israel
J Exp Med 208:901-8. 2011Interleukin-7 receptor α (IL7R) is required for normal lymphoid development. Loss-of-function mutations in this gene cause autosomal recessive severe combined immune deficiency...
- The IL-7Rα pathway is quantitatively and functionally altered in CD8 T cells in multiple sclerosisKarim L Kreft
Department of Neurology, Erasmus MC, University Medical Center, 3000 CA Rotterdam, The Netherlands
J Immunol 188:1874-83. 2012..This is of special interest in light of the established demyelinating and cytotoxic actions of granzyme A...
- IL-7 downregulates IL-7Rα expression in human CD8 T cells by two independent mechanismsFeras M Ghazawi
Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
Immunol Cell Biol 91:149-58. 2013..It is therefore no surprise that expression of the IL-7 receptor alpha-chain (CD127) is tightly regulated...
- Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamilyR G Goodwin
Immunex Corporation, Seattle, Washington 98101
Cell 60:941-51. 1990..Analysis of the sequence of the IL-7 receptor revealed significant homology in the extracellular domain to several recently cloned cytokine receptors, demonstrating that the IL-7 receptor is a member of a new receptor superfamily...
- IL-7R alpha gene expression is inversely correlated with cell cycle progression in IL-7-stimulated T lymphocytesLouise Swainson
Centre National de la Recherche Scientifique, Unite Mixte de Recherche 5535, Montpellier, France
J Immunol 176:6702-8. 2006..Thus, IL-7 therapy should be designed to allow optimal responsiveness of naive and memory T cell subsets...
- Decreased CD127 expression on T Cells in HIV-1-infected adults receiving antiretroviral therapy with or without intermittent IL-2 therapySarah W Read
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Acquir Immune Defic Syndr 42:537-44. 2006..We evaluated the IL-7/IL-7Ralpha system in a large cohort of HIV-infected patients, including a subset treated with intermittent IL-2...
- Interleukin-7 receptor expression on CD8 T-cells is downregulated by the HIV Tat proteinElliott M Faller
Ottawa Health Research Institute, Ottawa, Ontario, Canada
J Acquir Immune Defic Syndr 43:257-69. 2006We have previously shown decreased expression of the interleukin (IL)-7 receptor alpha-chain (CD127) on CD8 T-cells in HIV-infected patients and an apparent recovery of this receptor in those receiving antiretroviral therapy with ..
- Haplotypes of the interleukin 7 receptor alpha gene are correlated with altered expression in whole blood cells in multiple sclerosisF C McKay
Westmead Millennium Institute, University of Sydney, Sydney, Australia
Genes Immun 9:1-6. 2008IL7 regulates T cell survival, differentiation and proliferation. The alpha chain of its receptor, CD127, is polymorphic, and its haplotypes are associated with recovery from transplantation and with the autoimmune disease multiple ..
- CD127 and CD25 expression defines CD4+ T cell subsets that are differentially depleted during HIV infectionRichard M Dunham
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Immunol 180:5582-92. 2008..into three subsets by the expression of receptors for two T cell-tropic cytokines, IL-2 (CD25) and IL-7 (CD127)...
- Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptorM Noguchi
Section on Pulmonary and Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892
Science 262:1877-80. 1993..These findings may help explain the defects of XSCID. Given its role in more than one cytokine receptor system, the common gamma chain (gamma c) is proposed as the designation for IL-2R gamma...
- Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/- miceE Maraskovsky
Department of Cellular Immunology, Immunex Research and Development Corporation, Seattle, Washington 98101, USA
Cell 89:1011-9. 1997..These results provide evidence that blocking apoptosis is the essential function of IL-7R during differentiation and activation of T lymphocytes and that pre-TCR signaling blocks a pathway to apoptosis that is insensitive to Bcl-2...
- Interleukin 7 receptor alpha-chain-mutation severe combined immunodeficiency without lymphopenia: correction with haploidentical T-cell-depleted bone marrow transplantationPunita Ponda
Division of Allergy and Immunology, Department of Pediatrics, Schneider Children s Hospital, North Shore Long Island Jewish Health System, Great Neck, New York 11021, USA
Ann Allergy Asthma Immunol 97:755-8. 2006..It often presents during the first year of life with recurrent, opportunistic infections, failure to thrive, and malabsorption...
- [A compound heterozygosity mutation in the interleukin-7 receptor-alpha gene resulted in severe combined immunodeficiency in a Chinese patient]Zhi Yong Zhang
Department of Nephrology and Immunity, Children s Hospital, Chongqing Medical University, Chongqing 400014, China
Zhonghua Er Ke Za Zhi 47:691-5. 2009..Here we report the molecular and clinical characterization of a compound heterozygosity mutation in the interleukin-7 receptor-alpha gene that resulted in SCID in a patient firstly from China...
- Defective T-cell receptor gamma gene rearrangement in interleukin-7 receptor knockout miceS Candeias
SAIC, NCI FCRDC, Frederick, MD 21702 1201, USA
Immunol Lett 57:9-14. 1997..These findings indicate that one or both of the two known ligands of IL-7R, IL-7 and thymic stromal lymphopoietin (TSLP) serves as an extrinsic signal to specifically rearrange the TCR gamma locus...
- Interleukin 7 receptor control of T cell receptor gamma gene rearrangement: role of receptor-associated chains and locus accessibilityS K Durum
Laboratory of Molecular Immunoregulation, National Cancer Institute, Frederick, Maryland 21702, USA
J Exp Med 188:2233-41. 1998..This data supports the model that IL-7R promotes TCR-gamma gene rearrangement by regulating accessibility of the locus via demethylation and histone acetylation of the locus...
- Interleukin 7 receptor alpha chain haplotypes vary in their influence on multiple sclerosis susceptibility and response to interferon BetaEdwin Hoe
Westmead Millennium Institute, University of Sydney, Australia
J Interferon Cytokine Res 30:291-8. 2010b>Interleukin 7 receptor alpha chain (IL-7Ralpha) has recently been confirmed as the first non-HLA gene definitively associated with multiple sclerosis (MS)...
- Identification of 11 novel and common single nucleotide polymorphisms in the interleukin-7 receptor-alpha gene and their associations with multiple sclerosisSuzy M Teutsch
Institute for Immunology and Allergy Research Westmead Millennium Institute, Westmead Hospital, Westmead, NSW 2145, Australia
Eur J Hum Genet 11:509-15. 2003..These polymorphisms would also be useful for studying genetic associations with other immunologic diseases...
- Regulation of the interleukin-7 receptor alpha promoter by the Ets transcription factors PU.1 and GA-binding protein in developing B cellsRodney P DeKoter
Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
J Biol Chem 282:14194-204. 2007..consisting of a common gamma chain (gammac, encoded by Il2rg) and an alpha subunit (IL-7Ralpha, encoded by Il7r). The Il7r gene is expressed specifically in the immune system in a developmental stage-specific manner...
- Reduced numbers of IL-7 receptor (CD127) expressing immune cells and IL-7-signaling defects in peripheral blood from patients with breast cancerNalini Kumar Vudattu
Microbiology, Tumor and Cell Biology Center, Karolinska Institute, Solna, Sweden
Int J Cancer 121:1512-9. 2007..We studied IL-7Ralpha (CD127) expression in PBMCs obtained from patients with breast cancer and examined IL-7 receptor-mediated downstream ..
- Interleukin-7 is trophic for embryonic neurons and is expressed in developing brainM D Michaelson
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Dev Biol 179:251-63. 1996..Expression of the mRNA encoding the high-affinity IL7 receptor (IL7R) is observed in vitro in neurons as well as in subventricular zone progenitor cells...
- A transgenic T cell receptor restores thymocyte differentiation in interleukin-7 receptor alpha chain-deficient miceT Crompton
Imperial Cancer Research Fund, London, GB
Eur J Immunol 27:100-4. 1997..In contrast, once cells have progressed beyond the DN stage of development the IL-7R alpha chain becomes no longer essential for RAG expression...
- Distinct roles of the interleukin-7 receptor alpha chain in fetal and adult thymocyte development revealed by analysis of interleukin-7 receptor alpha-deficient miceT Crompton
Department of Biology, Imperial College of Science, Technology and Medicine, London, GB
Eur J Immunol 28:1859-66. 1998..These data suggest that the IL-7Ralpha chain is a key regulator of both survival and proliferation during thymocyte development but that it is not essential for the production of T cells during fetal thymopoiesis...
- Overlapping roles of CXCL13, interleukin 7 receptor alpha, and CCR7 ligands in lymph node developmentSanjiv A Luther
Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, 94143, USA
J Exp Med 197:1191-8. 2003..These findings indicate that CXCL13 and CCR7 ligands promote accumulation of CD4+ CD3- IL-7R alpha hi cells, delivering IL-7R alpha-dependent LT alpha 1 beta 2 signals critical for LN development...
- Infection of CD127+ (interleukin-7 receptor+) CD4+ cells and overexpression of CTLA-4 are linked to loss of antigen-specific CD4 T cells during primary human immunodeficiency virus type 1 infectionJohn J Zaunders
Centre for Immunology, St Vincent s Hospital, Victoria Street, Darlinghurst, NSW 2010, Australia
J Virol 80:10162-72. 2006..However, a small subset of HIV-specific CD4+) T cells also expressed CD127, a marker of long-term memory cells...
- Dual mechanism of impairment of interleukin-7 (IL-7) responses in human immunodeficiency virus infection: decreased IL-7 binding and abnormal activation of the JAK/STAT5 pathwayOlivier Juffroy
Institut Pasteur, Unité d Immunogénétique Cellulaire, 75724 Paris Cedex 15, France
J Virol 84:96-108. 2010..HIV infection differentially affected the expression of IL-7 receptor (IL-7R) chains, with decreases in IL-7Ralpha/CD127 expression in the memory subset and increases in gammac/CD132 expression in all CD4(+) T cells...
- Pre-pro-B cell growth-stimulating factor (PPBSF) upregulates IL-7Ralpha chain expression and enables pro-B cells to respond to monomeric IL-7Chiju Wei
Department of Pathology, School of Medicine, University of Connecticut Health Center, Farmington, CT 06030 3105, USA
J Interferon Cytokine Res 22:823-32. 2002....
- IL-7 receptor is present on human microvascular endothelial cellsDanuta Dus
Laboratory of Cellular Interactions, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Centre of Excellence IMMUNE, R Weigla 12, 53 114, Wroclaw, Poland
Immunol Lett 86:163-8. 2003..The receptor consists of two chains: IL-7 specific alpha chain (CD127) and the common gamma(c) chain (CD132) which is a component of several other cytokine receptors: IL-2, IL-4, IL-9 ..
- GA binding protein regulates interleukin 7 receptor alpha-chain gene expression in T cellsHai Hui Xue
Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 10, Room 7N252, Bethesda, Maryland 20892 1674, USA
Nat Immunol 5:1036-44. 2004....
- Loss of IL-7Ralpha is associated with CD4 T-cell depletion, high interleukin-7 levels and CD28 down-regulation in HIV infected patientsBence Rethi
Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
AIDS 19:2077-86. 2005..The subset(s) of T cells with low IL-7Ralpha and the consequence of low IL-7Ralpha expression for T-cell survival are poorly characterized...
- IL-7 receptor deficient SCID with a unique intronic mutation and post-transplant autoimmunity due to chronic GVHDManish J Butte
Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
Clin Immunol 125:159-64. 2007..Here we report a case of SCID due to heterozygous mutations of the IL7R gene encoding IL-7Ralpha...
- Characterisation and expression analysis of the chicken interleukin-7 receptor alpha chainDaphne A van Haarlem
Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht, The Netherlands
Dev Comp Immunol 33:1018-26. 2009..Upon polyclonal stimulation with ConA, IL-7Ralpha was rapidly down-regulated on T cells, suggesting that in the chicken expression of this receptor might also be correlated to the T cell activation status...
- Effects of transmembrane and juxtamembrane domains on proliferative ability of TSLP receptorJun Zhong
McKusick Nathans Institute of Genetic Medicine, Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Mol Immunol 47:1207-15. 2010....
- High content cellular immune profiling reveals differences between rhesus monkeys and menIsabelle Magalhaes
Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Solna, Sweden
Immunology 131:128-40. 2010..This provides a matrix to assess future efforts to study diseases and vaccines in NHPs...
- Increased numbers of IL-7 receptor molecules on CD4+CD25-CD107a+ T-cells in patients with autoimmune diseases affecting the central nervous systemNalini Kumar Vudattu
Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institutet, Stockholm, Sweden
PLoS ONE 4:e6534. 2009..High content immune profiling in peripheral blood may reflect immune aberrations associated with inflammation in multiple sclerosis (MS) and other autoimmune diseases affecting the central nervous system...
- Homeostatic cytokines and expansion of regulatory T cells accompany thymic impairment in children with Down syndromeErika Roat
Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
Rejuvenation Res 11:573-83. 2008..the proliferative T cell response to these cytokines, the expression of the alpha chain of the IL-7 receptor (CD127), the extrathymic differentiation of T lymphocytes, and the presence of natural regulatory T cells (Tregs) in ..
- IL-7 receptor alpha+ CD3(-) cells in the embryonic intestine induces the organizing center of Peyer's patchesH Yoshida
Department of Molecular Genetics, Faculty of Medicine, Institute of Genetics, Faculty of Medicine, Kyoto University, Syogoin Kawaharacho 53, Sakyoku, Kyoto 606 850, Japan
Int Immunol 11:643-55. 1999..0 d.p.c. (step II), and entry of CD3+ and B220+ lymphocytes just before birth (step III). PP formation of both Il7ra-/- and Lta-/- mice is impaired from step I, suggesting involvement of the two molecules at the same timing in PP ..
- Gastrointestinal cells of IL-7 receptor null mice exhibit increased sensitivity to irradiationL A Welniak
Laboratory of Leukocyte Biology, Division of Basic Sciences, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, MD 21702, USA
J Immunol 166:2924-8. 2001..This study describes a novel role of IL-7 in nonhematopoietic tissues...
- IL-7 receptor expression provides the potential for long-term survival of both CD62Lhigh central memory T cells and Th1 effector cells during Leishmania major infectionSara L Colpitts
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Immunol 182:5702-11. 2009..whether the prosurvival cytokine IL-7 contributes to maintaining these T cells, we examined expression of the IL7R on CD4(+) T cells activated during L. major infection...
- Patients with relapsing-remitting multiple sclerosis have normal Treg function when cells expressing IL-7 receptor alpha-chain are excluded from the analysisLaure Michel
INSERM U643, CHU Nantes, Institut de Transplantation et de Recherche en Transplantation ITERT, and Faculté de Médecine, Universite de Nantes, Nantes, France
J Clin Invest 118:3411-9. 2008..function of this T cell subset in patients with MS, but we depleted cells expressing IL-7 receptor alpha-chain (CD127), a marker recently described as present on activated T cells but not Tregs...
- Requirement for stat5 in thymic stromal lymphopoietin-mediated signal transductionD E Isaksen
Virginia Mason Research Center, Seattle, WA 98101, USA
J Immunol 163:5971-7. 1999..Moreover, TSLP-mediated signaling is inhibited by suppressor of cytokine signaling (SOCS)-1 and a kinase-deficient version of Tec but not by kinase-deficient forms of Jak1 and Jak2...
- IL-7 receptor signaling is necessary for stage transition in adult B cell development through up-regulation of EBFKazu Kikuchi
Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
J Exp Med 201:1197-203. 2005..Thus, IL-7 receptor signaling is a participant in the formation of the transcription factor network during B lymphopoiesis by up-regulating EBF, allowing stage transition from the pre-pro-B to further maturational stages...
- Transcriptional regulation of the mouse IL-7 receptor alpha promoter by glucocorticoid receptorHai Chon Lee
Laboratory of Biological Protection, Department of Biological Responses, Institute for Virus Research, Kyoto University, Kyoto, Japan
J Immunol 174:7800-6. 2005..Thus, this study identifies the IL-7Ralpha CNS-1 region as a GC-responsive element...
- c-Myb is required for pro-B cell differentiationShawn P Fahl
Department of Microbiology, University of Virginia Health System, Charlottesville, VA 22908, USA
J Immunol 183:5582-92. 2009..survival of CD19(+) pro-B cells as well as the proper expression of the alpha-chain of the IL-7 receptor (CD127) and Ebf1...
- Cloning of a receptor subunit required for signaling by thymic stromal lymphopoietinA Pandey
Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
Nat Immunol 1:59-64. 2000..Cloning of TSLPR should facilitate an understanding of TSLP function and its signaling mechanism...
- Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cellsAdam S Lazorchak
Department of Immunobiology, Yale School of Medicine, New Haven, CT 06519, USA
Mol Cell 39:433-43. 2010..Sin1 deficiency results in increased IL-7 receptor (il7r) and RAG recombinase (rag1 and rag2) gene expression, leading to enhanced pro-B cell survival and augmented V(D)J ..
- IL-7 receptor is expressed on adult pre-B-cell acute lymphoblastic leukemia and other B-cell derived neoplasms and correlates with expression of proliferation and survival markersSarah C Sasson
National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia
Cytokine 50:58-68. 2010..Surface expression of IL-7R components CD127 and CD132, and intracellular Ki-67 and Bcl-2 were examined by flow cytometry on peripheral blood or bone marrow ..
- Interleukin-4 downregulates CD127 expression and activity on human thymocytes and mature CD8+ T cellsAngela M Crawley
Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
Eur J Immunol 40:1396-407. 2010Signaling via the IL-7 receptor complex (IL-7Ralpha/CD127 and IL-2Rgamma/CD132) is required for T-cell development and survival. Decreased CD127 expression has been associated with persistent viral infections (e.g. HIV, HCV) and cancer...
- Overexpression of IL-7R alpha provides a competitive advantage during early T-cell developmentYasmina Laouar
Section of Immunobiology, Yale University School of Medicine, 300 Ceda St, CAB S 569, New Haven, CT 06520, USA
Blood 103:1985-94. 2004..This advantage occurred at early stages of T-cell development. Our findings support the model that overexpression of growth factor receptors can contribute to proliferation and malignancy...
- STAT5 activation underlies IL7 receptor-dependent B cell developmentChristine A Goetz
Department of Laboratory Medicine and Pathology, Center for Immunology, Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
J Immunol 172:4770-8. 2004Signals initiated by the IL7R are required for B cell development. However, the roles that distinct IL7R-induced signaling pathways play in this process remains unclear...
- Induction of the IL-7 receptor alpha chain in mouse peripheral B cells by glucocorticoidsHirofumi Shibata
Laboratory of Biological Protection, Department of Biological Responses, Institute for Virus Research, Kyoto University, 53 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
Immunol Lett 111:45-50. 2007..Therefore, this study demonstrates that GCs induce the transcription and expression of functional IL-7R alpha in peripheral B cells, and implies a potential role of the IL-7R in survival of B cells...
- Antigen controls IL-7R alpha expression levels on CD8 T cells during full activation or tolerance inductionChristopher D Hammerbeck
Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
J Immunol 180:2107-16. 2008The high-affinity chain of the IL-7 receptor, IL-7Ralpha (CD127), is expressed by effector CD8 T cells that have the capacity to become memory cells...
- Molecular cloning and expression analysis of CD127 in pigYu Jin Hur
Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea
Anim Biotechnol 20:40-5. 2009b>CD127 (the alpha chain of the IL-7 receptor) is an 80 kDa type I membrane glycoprotein that mediates the signal for the differentiation, maturation, and survival of lymphocyte development...
- Impaired survival and proliferation in IL-7 receptor-deficient peripheral T cellsE Maraskovsky
Department of Cellular Immunology, Immunex Corporation, Seattle, WA 98101, USA
J Immunol 157:5315-23. 1996..We propose that an absence of IL-7R signaling not only affects T cell development in the thymus, but also results in the accumulation of functionally inactive T cells in the periphery...
- Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient miceK Akashi
Department of Pathology, Stanford University School of Medicine, California 94305, USA
Cell 89:1033-41. 1997..We propose cell survival signals to be the principal function of IL-7R engagement in thymic and T cell development...
- Different cytokines induce surface lymphotoxin-alphabeta on IL-7 receptor-alpha cells that differentially engender lymph nodes and Peyer's patchesHisahiro Yoshida
Division of Immunogenetics, Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Japan
Immunity 17:823-33. 2002..Soluble IL-7 administered to TRAF6(-/-) embryos was sufficient to restore LN genesis indicating the functional similarities of the IL-7R(alpha)(+) inducer cells for LN and PP genesis...
- IL-7/IL-7 receptor system regulation following IL-2 immunotherapy in HIV-infected patientsGiulia Marchetti
Institute of Infectious Diseases and Tropical Medicine, Luigi Sacco Hospital, University of Milan, Milan, Italy
Antivir Ther 9:447-52. 2004..Our data confirm the pivotal role of IL-2 and IL-7 in the regulation of T-lymphocyte homeostasis in HIV infection...
- Inherited disorders of cytokinesCapucine Picard
Unité d Immunologie et d Hématologie Pédiatriques, Hopital Necker Enfants Malades, and Laboratoire de Génétique Humaine des Maladies Infectieuses, Université de Paris René Descartes INSERM U550, Faculte de Medecine Necker, Paris, France
Curr Opin Pediatr 16:648-58. 2004..Cytokines are soluble mediators involved in the development or function of the immune system. This paper reviews the literature on childhood-onset inherited disorders associated with impaired cytokine-mediated immunity...
- IL-7R alpha versus CCR7 and CD45 as markers of virus-specific CD8+ T cell differentiation: contrasting pictures in blood and tonsillar lymphoid tissueD Sauce
Cancer Research UK Institute for Cancer Studies, University of Birmingham, B15 2TT Birmingham, United Kingdom
J Infect Dis 195:268-78. 2007..As a discriminator between different virus-specific populations, IL-7R alpha therefore appears to be more susceptible to tissue location than the classical CCR7/CD45 markers...
- Formation of IL-7Ralphahigh and IL-7Ralphalow CD8 T cells during infection is regulated by the opposing functions of GABPalpha and Gfi-1Anmol Chandele
Department of Immunobiology, Yale Medical School, New Haven, CT 06511, USA
J Immunol 180:5309-19. 2008..for IL-7Ralpha expression in memory precursor effector cells, and this correlated with hyperacetylation of the Il7ra promoter...
- Loss of CD127 expression links immune activation and CD4(+) T cell loss in HIV infectionSandra A Koesters Kiazyk
Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba R3E 0W3, Canada
Trends Microbiol 16:567-73. 2008..We propose that reduced expression of CD127 (IL-7 receptor alpha chain, IL-7Ralpha), induced by immune activation, contributes to CD4(+) T cell loss in HIV ..
- Trophic Regulation in T Cell Homeostasis and DiseaseJeffrey C Rathmell; Fiscal Year: 2010..and intracellular trafficking by adoptive transfer of T cells into IL7-/- hosts and conditional deletion of IL7R in mature T cells. (2) Identify signaling mechanisms that regulate Glutl expression and cell surface localization...
- Regulation of memory CD8 T cell developmentSusan M Kaech; Fiscal Year: 2012..abstract_text> ..
- Jennifer M Puck; Fiscal Year: 2014..of humans with cytokine signaling pathway defects in the common g chain (gc) receptor, the IL-7 receptor a chain (IL7Ra), and Janus kinase 3 (Jak3), whereas the mouse knockouts lacking these proteins differ from humans in having T ..
- Molecular Recognition Studies of the Interleukin-7 PathwaySCOTT T WALSH; Fiscal Year: 2012....
- Ming Li; Fiscal Year: 2014..To determine the function of compromised CD127 (IL-7 receptor alpha chain) expression in TGF-beta receptor II-deficient thymocytes and naive T cells, a strain of ..
- IL7 AND IL7R TARGETED THERAPEUTIC AGENTS FOR LEUKEMIAJohn Murphy; Fiscal Year: 2000..Thus, IL7(W143A) was the first IL7R antagonist to be reported...
- Benigno Rodriguez; Fiscal Year: 2016..This is caused by IL-6 mediated inhibition of the IL-7 receptor [unreadable] chain - CD127 and IL-6-mediated activation of central memory CD4 T cell cycling and death...
- ROLE OF IL-7 IN DECREASED THYMOPOIESIS OF AGINGMarilyn Thoman; Fiscal Year: 2006..It is anticipated that these studies will lead to the development of strategies to enhance T lymphopoiesis and thereby improve immune function in the elderly as well as other immunodeficient adults. ..
- Immune Response to Cat: Regulatory and Effector T CellsJudith A Woodfolk; Fiscal Year: 2013..Low expression of CD127 (IL-7R 1 chain) will be used to isolate natural (CD25+CD127lo) and adaptive (CD25negCD127lo) Tregs from AD ..
- MARKUS MUSCHEN; Fiscal Year: 2015..In preliminary work for this proposal, we found that IL7R?/Stat5/Akt signaling is critical to keep normal pre-B cells in an antigen- unresponsive state...
- Defining the Functional Role of a Novel MS Susceptibility Gene, IL7R alpha chainSimon G Gregory; Fiscal Year: 2013DESCRIPTION (provided by applicant): Defining the functional role of a novel MS susceptibility gene, IL7R alpha chain...
- Development of Intestinal Immune Regulation in Human InfantsJOERN HENDRIK WEITKAMP; Fiscal Year: 2013..characterized as interleukin-2 receptor a (IL-2Ra = CD25)''"3'''CD4^ CD45RO* IL-7R (CD127)*"'T cells expressing high levels of the transcription factor forkhead box protein 3 (FOXPS)...
- UTPAL P DAVE; Fiscal Year: 2016..tyrosine kinase that binds with IL2RG to transduce signals from multiple cytokine receptors (IL2R, IL4R, IL7R, IL9R, IL15R, and IL21R) upon ligand binding...
- T Cell Homeostasis in Systemic AutoimmunityArgyrios N Theofilopoulos; Fiscal Year: 2012..that the highly expanded double-negative (DN) CD4[unreadable]CD8[unreadable] T cells do not express IL- 7R (CD127) or IL-15R (CD122)...
- TSLP AND LYMPHOPOIESISAndrew Farr; Fiscal Year: 2003..Third, because of preliminary data indicating that the IL7R contributes to the functional TSLP receptor, the hypothesis that the action of TSLP, which is highly expressed in ..
- REGULATION OF V(D)J RECOMBINATION IN B CELL DEVELOPMENTRachel M Gerstein; Fiscal Year: 2011..Specific Aim 1 is to determine the mechanism by the IL7R:JAK3:pSTAT5 pathway regulates the V(D)J recombinase...
- Prime/Boost Vaccine to Prevent Hepatocellular CarcinomaJOHN HAYWARD ELDRIDGE; Fiscal Year: 2012..Second, IL-12 is known to up regulate CD28 and CD127 expression on T cells and to be a potent inhibitor of tolerance induction...
- Mechanisms of Immune Evasion by Hepatitis C VirusAndrea L Cox; Fiscal Year: 2012..clear HCV infection and those who progress to chronic infection 2) test the hypothesis that expression of PD-1 and CD127 affects the function of CD8 T cells specific for non-mutated HCV epitopes and evaluate mechanisms of regulation of ..
- Mechanisms of tolerance in recipients of combined kidney and bone marrow transplaMegan Sykes; Fiscal Year: 2010..of the development of anti-donor antibodies;and 2) Assess the role of regulatory cells, including FoxP3+ Treg and CD127-C025-C04 cells, in the development of donor-specific tolerance in recipients of CKBMT...
- Comparison of B Cell Differentiation in Mice and HumansMAX DALE COOPER; Fiscal Year: 2010..and dominant-negative transgenes, and (iv) examine the effects of ligating cell surface receptors (preBCR, BCR, IL7R, CD19, CD32, and CD40) on growth and differentiation of these B lineage cells...
- IFN-a and pDC in HIV infection: impact on T cell development and reconstitutionChristel H Uittenbogaart; Fiscal Year: 2013..show that HIV-1-induced IFN-?? production inhibits early stages of human T cell development by impairing the IL-7/IL7R pathway...
- Genetic Epidemiology of Multiple SclerosisJonathan L Haines; Fiscal Year: 2010..new genetic association in MS in over 30 years;we demonstrated that a common non-synonymous functional SNP in the IL7RA gene was associated with an increased risk of MS...
- Regulation of B Cell Development by Ras and RafMichael Farrar; Fiscal Year: 2002..Thus the aims of this application are: (1) To determine whether the IL7R or flk2/flt3 entrain early B cell development via Ras activation, (2) To determine whether Ras/Raf-dependent early ..
- Innate and adaptive immunity in children starting anir*Savita Pahwa; Fiscal Year: 2007..The nadir of NaTve CD4 T cells prior to starting ART predicts capacity for CD4 T Cell reconstitution; 2. Loss of CD127+ CDS T Cells or expansion of CD127-CD8 T Cells is associated with aberrant immune activation and disease ..
- Epidemiology of Regulatory T Cells in Pregnancy and Childhood Atopic DiseasesGanesa Wegienka; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..
- Memory CD8 T cell subset cooperation via chemokines in protective immunity to infE Wherry; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Pathogen-specific T cell responses in patients with SLEInsoo Kang; Fiscal Year: 2008..abstract_text> ..
- Investigating aging and membrane-associated T cell receptor signaling in human CDInsoo Kang; Fiscal Year: 2008..Recently, my lab measured expression of IL-7 receptor alpha chain (IL-7Ra, CD127) which dictates the response to IL-7, a cytokine critical for T cell homeostasis, on CD8+ T cells in young and ..
- MVA/HIV-48: Potential Dual Vaccine for HIV and SmallpoxRama Rao Amara; Fiscal Year: 2003..The project will be a collaborative undertaking between researchers at the CDC, the NIAID, and the NIAID HIV Vaccine Trial Network (HVTN ). The focus of this application is the quantification and phenotyping of responding T cells. ..
- Roles of Nod2 in the Pathogenesis of Crohn's DiseaseRichard Flavell; Fiscal Year: 2008..Furthermore, by using mice in which Rip2, the kinase downstream of Nod2, is deficient, we will try to reveal if the IBD pathology caused by Nod2 mutation is dependent on Rip2. [unreadable] [unreadable]..
- The Role of IL-2 in Autoimmune DiabetesRichard Flavell; Fiscal Year: 2007..We will utilize our IL-2 knock-in mice to test these two mutually nonexclusive hypotheses. ..
- Vaccine responsiveness to Borrelia burgdorferi OspARichard Flavell; Fiscal Year: 2007..abstract_text> ..
- TOLERANCE OF ISLET CELL GRAFTJeffrey Bluestone; Fiscal Year: 2001..The outcome of these studies will have important implications for islet cell transplantation for the treatment of IDDM. ..
- Dys/Regulation of the Immune System in AutoimmunityRichard Flavell; Fiscal Year: 2006..The program is coordinated by frequent meetings of the program faculty and research workers bringing together these diverse approaches to address a common goal. ..
- Immunomodulation in Multiple Sclerosis by Interferon BJorge Oksenberg; Fiscal Year: 2005..In addition to new insights into the fundamental biology of interferons, our results will potentially identify surrogate markers of activity, and define the molecular basis of interferon response heterogeneity. ..