IL7R

Summary

Gene Symbol: IL7R
Description: interleukin 7 receptor
Alias: CD127, CDW127, IL-7R-alpha, IL7RA, ILRA, interleukin-7 receptor subunit alpha, CD127 antigen, IL-7 receptor subunit alpha, IL-7R subunit alpha, interleukin 7 receptor alpha chain, interleukin 7 receptor isoform H5-6
Species: human

Top Publications

  1. pmc Upregulation of interleukin 7 receptor alpha and programmed death 1 marks an epitope-specific CD8+ T-cell response that disappears following primary Epstein-Barr virus infection
    Delphine Sauce
    CRUK Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Virol 83:9068-78. 2009
  2. pmc Concentration and activity of the soluble form of the interleukin-7 receptor α in type 1 diabetes identifies an interplay between hyperglycemia and immune function
    Paolo Monti
    San Raffaele Diabetes Research Institute, San Raffaele Scientific Institute, Milan, Italy
    Diabetes 62:2500-8. 2013
  3. ncbi HIV regulation of the IL-7R: a viral mechanism for enhancing HIV-1 replication in human macrophages in vitro
    Mingjie Zhang
    Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, FDA, 1401 Rockville Pike, Rockville, MD 20852 1448, USA
    J Leukoc Biol 79:1328-38. 2006
  4. ncbi Interleukin (IL)-7 induces rapid activation of Pyk2, which is bound to Janus kinase 1 and IL-7Ralpha
    N Benbernou
    Intramural Research Support Program, SAIC Frederick, NCI Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
    J Biol Chem 275:7060-5. 2000
  5. pmc Organization of the murine and human interleukin-7 receptor genes: two mRNAs generated by differential splicing and presence of a type I-interferon-inducible promoter
    C M Pleiman
    Department of Molecular Biology, Immunex Corporation, Seattle, Washington 98101
    Mol Cell Biol 11:3052-9. 1991
  6. ncbi Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency
    A Puel
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1674, USA
    Nat Genet 20:394-7. 1998
  7. ncbi A partial deficiency of interleukin-7R alpha is sufficient to abrogate T-cell development and cause severe combined immunodeficiency
    C M Roifman
    Division of Immunology Allergy, Department of Paediatrics, The Hospital for Sick Children, Toronto, Canada
    Blood 96:2803-7. 2000
  8. ncbi Two genes encoding immune-regulatory molecules (LAG3 and IL7R) confer susceptibility to multiple sclerosis
    Z Zhang
    Department of Molecular Sciences, Section for Genetics and Bioinformatics, AstraZeneca R and D Sodertalje, Sodertalje, Sweden
    Genes Immun 6:145-52. 2005
  9. ncbi Loss of CD127 expression defines an expansion of effector CD8+ T cells in HIV-infected individuals
    Mirko Paiardini
    Department of Medicine, and Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 174:2900-9. 2005
  10. ncbi Cutting edge: emergence of CD127high functionally competent memory T cells is compromised by high viral loads and inadequate T cell help
    Michael J Fuller
    Department of Microbiology, University of Alabama, Birmingham, AL 35294, USA
    J Immunol 174:5926-30. 2005

Research Grants

  1. Trophic Regulation in T Cell Homeostasis and Disease
    Jeffrey C Rathmell; Fiscal Year: 2010
  2. Regulation of memory CD8 T cell development
    Susan M Kaech; Fiscal Year: 2012
  3. Jennifer M Puck; Fiscal Year: 2014
  4. Molecular Recognition Studies of the Interleukin-7 Pathway
    SCOTT T WALSH; Fiscal Year: 2012
  5. Ming Li; Fiscal Year: 2014
  6. IL7 AND IL7R TARGETED THERAPEUTIC AGENTS FOR LEUKEMIA
    John Murphy; Fiscal Year: 2000
  7. Benigno Rodriguez; Fiscal Year: 2016
  8. ROLE OF IL-7 IN DECREASED THYMOPOIESIS OF AGING
    Marilyn Thoman; Fiscal Year: 2006
  9. Immune Response to Cat: Regulatory and Effector T Cells
    Judith A Woodfolk; Fiscal Year: 2013
  10. MARKUS MUSCHEN; Fiscal Year: 2015

Detail Information

Publications210 found, 100 shown here

  1. pmc Upregulation of interleukin 7 receptor alpha and programmed death 1 marks an epitope-specific CD8+ T-cell response that disappears following primary Epstein-Barr virus infection
    Delphine Sauce
    CRUK Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Virol 83:9068-78. 2009
    ..but showed unique temporal changes in two markers of T-cell fate, interleukin 7 receptor alpha (IL-7Ralpha; CD127) and programmed death 1 (PD-1)...
  2. pmc Concentration and activity of the soluble form of the interleukin-7 receptor α in type 1 diabetes identifies an interplay between hyperglycemia and immune function
    Paolo Monti
    San Raffaele Diabetes Research Institute, San Raffaele Scientific Institute, Milan, Italy
    Diabetes 62:2500-8. 2013
    ..The findings indicate that genetic, immunologic, and metabolic factors contribute to a dysregulation of the IL-7/IL-7 receptor pathway in T1D and identify a novel hyperglycemia-mediated interference of immune regulatory networks. ..
  3. ncbi HIV regulation of the IL-7R: a viral mechanism for enhancing HIV-1 replication in human macrophages in vitro
    Mingjie Zhang
    Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, FDA, 1401 Rockville Pike, Rockville, MD 20852 1448, USA
    J Leukoc Biol 79:1328-38. 2006
    ..The results suggest that the effects of IL-7 on HIV replication in MDM should be considered when analyzing and designing clinical trials involving treatment of patients with IL-7 or Tat vaccines...
  4. ncbi Interleukin (IL)-7 induces rapid activation of Pyk2, which is bound to Janus kinase 1 and IL-7Ralpha
    N Benbernou
    Intramural Research Support Program, SAIC Frederick, NCI Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
    J Biol Chem 275:7060-5. 2000
    ..These data support a role for Pyk2 in coupling Jak signaling to the trophic response...
  5. pmc Organization of the murine and human interleukin-7 receptor genes: two mRNAs generated by differential splicing and presence of a type I-interferon-inducible promoter
    C M Pleiman
    Department of Molecular Biology, Immunex Corporation, Seattle, Washington 98101
    Mol Cell Biol 11:3052-9. 1991
    ..Comparison of the murine and human IL-7R exon/intron boundaries with those of other hematopoietin receptor superfamily members whose exon/intron boundaries are also known reveals a conserved evolutionary structure...
  6. ncbi Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency
    A Puel
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1674, USA
    Nat Genet 20:394-7. 1998
    ..Some SCID patients lack T cells but retain NK cells. Given diminished T-cell development in Il7- or Il7r-deficient mice and that Il/7r-deficient mice have NK cells, we hypothesized that T(-)B(+)NK(+) SCID might result ..
  7. ncbi A partial deficiency of interleukin-7R alpha is sufficient to abrogate T-cell development and cause severe combined immunodeficiency
    C M Roifman
    Division of Immunology Allergy, Department of Paediatrics, The Hospital for Sick Children, Toronto, Canada
    Blood 96:2803-7. 2000
    ..This underscores the critical role of IL-7R alpha chain in the differentiation of T cells. (Blood. 2000;96:2803-2807)..
  8. ncbi Two genes encoding immune-regulatory molecules (LAG3 and IL7R) confer susceptibility to multiple sclerosis
    Z Zhang
    Department of Molecular Sciences, Section for Genetics and Bioinformatics, AstraZeneca R and D Sodertalje, Sodertalje, Sweden
    Genes Immun 6:145-52. 2005
    ..05) associated SNPs--conferred susceptibility to MS: LAG3 on chromosome 12p13, and IL7R on 5p13. LAG3 inhibits activated T cells, while IL7R is necessary for the maturation of T and B cells...
  9. ncbi Loss of CD127 expression defines an expansion of effector CD8+ T cells in HIV-infected individuals
    Mirko Paiardini
    Department of Medicine, and Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 174:2900-9. 2005
    ..In this study we show that in HIV-infected individuals the loss of IL-7R (CD127) expression defines the expansion of a subset of CD8(+) T cells, specific for HIV as well as other Ags, that show ..
  10. ncbi Cutting edge: emergence of CD127high functionally competent memory T cells is compromised by high viral loads and inadequate T cell help
    Michael J Fuller
    Department of Microbiology, University of Alabama, Birmingham, AL 35294, USA
    J Immunol 174:5926-30. 2005
    ..report we have inspected whether difficulties in controlling viral infections negatively impacts the generation of CD127(high) memory T cells...
  11. pmc Altered IL-7Ralpha expression with aging and the potential implications of IL-7 therapy on CD8+ T-cell immune responses
    Hang Rae Kim
    Section of Rheumatology, Department of Internal Medicine, TAC S541C, Yale School of Medicine, PO Box 208031, New Haven, CT 06520
    Blood 107:2855-62. 2006
    ....
  12. ncbi Genetic polymorphisms in the genes encoding human interleukin-7 receptor-alpha: prognostic significance in allogeneic stem cell transplantation
    Z Shamim
    The Tissue Typing Laboratory, Rigshospitalet, Copenhagen, Denmark
    Bone Marrow Transplant 37:485-91. 2006
    ..These findings suggest that the IL-7Ralpha polymorphisms may be of importance for treatment-related mortality after SCT...
  13. pmc Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells
    Nabila Seddiki
    Centenary Institute of Cancer Medicine and Cell Biology, Faculty of Medicine, University of Sydney, Newtown, NSW 2042, Australia
    J Exp Med 203:1693-700. 2006
    ..Here, we show that expression of CD127, the alpha chain of the interleukin-7 receptor, allows an unambiguous flow cytometry-based distinction to be made ..
  14. pmc CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells
    Weihong Liu
    UCSF Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 203:1701-11. 2006
    ..We found that the IL-7 receptor (CD127) is down-regulated on a subset of CD4(+) T cells in peripheral blood...
  15. ncbi Notch1 and IL-7 receptor interplay maintains proliferation of human thymic progenitors while suppressing non-T cell fates
    Marina García-Peydró
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Madrid, Spain
    J Immunol 177:3711-20. 2006
    ..These data provide insight into a mechanism of Notch-regulated amplification of the intrathymic pool of early human T cell progenitors...
  16. ncbi Human CD4+ regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cells
    DENNIS J HARTIGAN-O'CONNOR
    Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    J Immunol Methods 319:41-52. 2007
    ..T-regs, but consistent and specific discrimination of functional T-regs was only made possible by focus on CD127, the alpha chain of the IL-7 receptor...
  17. pmc Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes
    John A Todd
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 0XY, UK
    Nat Genet 39:857-64. 2007
    ..Several regions, including 18q22 and 18p11, showed association with autoimmune thyroid disease. This study increases the number of T1D loci with compelling evidence from six to at least ten...
  18. ncbi Risk alleles for multiple sclerosis identified by a genomewide study
    David A Hafler
    Division of Molecular Immunology, Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, and Harvard Medical School, Boston, USA
    N Engl J Med 357:851-62. 2007
    ..Multiple sclerosis has a clinically significant heritable component. We conducted a genomewide association study to identify alleles associated with the risk of multiple sclerosis...
  19. ncbi Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis
    Frida Lundmark
    Division of Neurology, Department of Clinical Neuroscience, Karolinska Institutet at Karolinska University Hospital Huddinge, SE 141 86 Stockholm, Sweden
    Nat Genet 39:1108-13. 2007
    ..Here, we report compelling evidence that polymorphisms in IL7R, which encodes the interleukin 7 receptor alpha chain (IL7Ralpha), indeed contribute to the non-HLA genetic risk in multiple sclerosis, demonstrating a ..
  20. ncbi Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis
    Simon G Gregory
    Center for Human Genetics, Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Genet 39:1083-91. 2007
    ..We describe allelic association of a polymorphism in the gene encoding the interleukin 7 receptor alpha chain (IL7R) as a significant risk factor for multiple sclerosis in four independent family-based or case-..
  21. ncbi IL-7 decreases IL-7 receptor alpha (CD127) expression and induces the shedding of CD127 by human CD8+ T cells
    Agatha Vranjkovic
    Ottawa Health Research Institute, Ottawa, ON, Canada
    Int Immunol 19:1329-39. 2007
    IL-7 receptor alpha (CD127) signaling is essential for T-cell development and regulation of naive and memory T-cell homeostasis...
  22. doi Study of the association between the CAPSL-IL7R locus and type 1 diabetes
    J L Santiago
    Department of Immunology, Hospital Clinico San Carlos, Martin Lagos s n, 28040 Madrid, Spain
    Diabetologia 51:1653-8. 2008
    ..in a large white population and corroborated in a genome-wide analysis, which also found an association with IL7R, which is located adjacent to CAPSL...
  23. doi Down-regulation of interleukin-7 receptor (CD127) in HIV infection is associated with T cell activation and is a main factor influencing restoration of CD4(+) cells after antiretroviral therapy
    Jose M Benito
    Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain
    J Infect Dis 198:1466-73. 2008
    ..Recently, attention has been paid to interleukin (IL)-7 and its receptor (CD127)...
  24. pmc IL-2 receptor gamma chain cytokines differentially regulate human CD8+CD127+ and CD8+CD127- T cell division and susceptibility to apoptosis
    Angela M Crawley
    Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada
    Int Immunol 21:29-42. 2009
    Expression of IL-7 receptor alpha (CD127) is associated with naive and memory (i.e. non-effector) CD8+ T cell phenotypes. Effector CD8+ T cells are predominantly CD127- and most die by apoptosis...
  25. pmc Structural and biophysical studies of the human IL-7/IL-7Ralpha complex
    Craig A McElroy
    Department of Molecular and Cellular Biochemistry, College of Medicine, Comprehensive Cancer Center, Ohio State University, 467 Hamilton Hall, 1645 Neil Avenue, Columbus, OH 43210, USA
    Structure 17:54-65. 2009
    ..The IL-7/IL-7Ralpha structures provide a window into the molecular recognition events of the IL-7 signaling cascade and provide sites to target for designing new therapeutics to treat IL-7-related diseases...
  26. doi IL-7 and the HIV Tat protein act synergistically to down-regulate CD127 expression on CD8 T cells
    Elliott Faller
    Ottawa Health Research Institute, 501 Smyth Road, Ottawa, Ontario, Canada
    Int Immunol 21:203-16. 2009
    ..We have previously shown decreased expression of the IL-7 receptor alpha-chain (CD127) on CD8 T cells from HIV-infected patients with active viral replication...
  27. pmc Interleukin-7 receptor signaling is deficient in CD4+ T cells from HIV-infected persons and is inversely associated with aging
    Douglas A Bazdar
    Division of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University, and University Hospitals, Cleveland, Ohio 44106, USA
    J Infect Dis 199:1019-28. 2009
    ..Although CD127 expression was diminished for T cells from HIV-infected persons, it was not directly related to IL-7 receptor ..
  28. doi Interleukin-7 receptor-alpha gene polymorphisms in bone marrow transplant recipients
    Negar Azarpira
    Organ Transplant Research Center, Shiraz University of Medical Sciences, Zand Street, Nemazi Hospital, Shiraz, Iran
    Mol Biol Rep 37:27-31. 2010
    ..Its effect is mediated via interleukin 7 receptor (IL7R)...
  29. doi Identification and biochemical characterization of human plasma soluble IL-7R: lower concentrations in HIV-1-infected patients
    Thierry Rose
    Institut Pasteur, Unité d Immunogénétique Cellulaire, Paris France
    J Immunol 182:7389-97. 2009
    ..0014) 2-fold decrease in plasma sIL-7Ralpha levels compared with those in control healthy individuals. Plasma IL-7 and sIL-7Ralpha levels did not show any obvious relationship...
  30. pmc Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci
    Philip L De Jager
    Division of Molecular Immunology, Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Nat Genet 41:776-82. 2009
    ....
  31. doi Elevated expression of interleukin-7 receptor in inflamed joints mediates interleukin-7-induced immune activation in rheumatoid arthritis
    Sarita A Y Hartgring
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 60:2595-605. 2009
    ..To evaluate the expression and functional ability of the high-affinity interleukin-7 receptor (IL-7Ralpha) in patients with rheumatoid arthritis (RA)...
  32. doi IL7RA polymorphisms and chronic inflammatory arthropathies
    C O'Doherty
    School of Pharmacy and Medical Sciences, City East Campus, University of South Australia, Adelaide, Australia
    Tissue Antigens 74:429-31. 2009
    ..C allele of a single nucleotide polymorphism (SNP), rs6897932, located in the interleukin-7 receptor alpha chain (IL7RA) was recently found to be associated with multiple sclerosis and Type I diabetes...
  33. doi Replication of CD58 and CLEC16A as genome-wide significant risk genes for multiple sclerosis
    Ilse A Hoppenbrouwers
    Department of Neurology, MS Centre ErasMS, Erasmus MC, Rotterdam, The Netherlands
    J Hum Genet 54:676-80. 2009
    ..Of the 17 IMSGC SNPs, five SNPs showed genome-wide significant association with MS: HLA-DRA (P=8E-124), IL7R (P=6E-09), IL2RA (P=1E-11), CD58 (P=4E-09) and CLEC16A (P=3E-12)...
  34. pmc Multiple sclerosis susceptibility alleles in African Americans
    B A Johnson
    Department of Neurology, University of California, San Francisco, CA 94143, USA
    Genes Immun 11:343-50. 2010
    ..None of the tested variants showed results that were statistically inconsistent with the effects established in whites. The results are consistent with shared disease genetic mechanisms among individuals of European and African ancestry...
  35. pmc Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score
    Philip L De Jager
    Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Lancet Neurol 8:1111-9. 2009
    ..We investigated the usefulness of an aggregate measure of risk of MS that is based on genetic susceptibility loci. We also assessed the added effect of environmental risk factors that are associated with susceptibility for MS...
  36. doi Functionally significant differences in expression of disease-associated IL-7 receptor alpha haplotypes in CD4 T cells and dendritic cells
    Edwin Hoe
    Westmead Millennium Institute, University of Sydney, Westmead, New South Wales, Australia
    J Immunol 184:2512-7. 2010
    ..Because signaling through IL-7Ralpha controls T cell regulation, this haplotype difference is likely to affect the immunophenotype and disease pathogenesis...
  37. doi IL-7 induces rapid clathrin-mediated internalization and JAK3-dependent degradation of IL-7Ralpha in T cells
    Catarina M Henriques
    Cancer Biology Unit, Instituto de Medicina Molecular, Lisbon University Medical School, Lisbon, Portugal
    Blood 115:3269-77. 2010
    ..It is well established that IL-7 promotes the transcriptional down-regulation of IL7RA, leading to decreased IL-7Ralpha surface expression...
  38. doi Soluble IL-7R alpha (sCD127) inhibits IL-7 activity and is increased in HIV infection
    Angela M Crawley
    Ottawa Hospital Research Institute, ON, Canada
    J Immunol 184:4679-87. 2010
    Soluble CD127 (sCD127) appears to play an important role in the immunopathogenesis of several chronic infections, multiple sclerosis, and various cancers...
  39. doi Soluble HIV Tat protein removes the IL-7 receptor alpha-chain from the surface of resting CD8 T cells and targets it for degradation
    Elliott M Faller
    Ottawa Hospital Research Institute
    J Immunol 185:2854-66. 2010
    ..We have previously shown decreased expression of the IL-7R alpha-chain (CD127) on CD8 T cells in HIV(+) patients and that this downregulation is mediated at least in part by the HIV Tat ..
  40. doi Biological determinants of immune reconstitution in HIV-infected patients receiving antiretroviral therapy: the role of interleukin 7 and interleukin 7 receptor α and microbial translocation
    Reena Rajasuriar
    Department of Medicine, Monash University, Burnet Institute, University of Melbourne, Melbourne, Australia
    J Infect Dis 202:1254-64. 2010
    ..We hypothesized that residual immune activation and polymorphisms in the interleukin 7 (IL-7) receptor α (IL-7Rα) gene were important for immune recovery...
  41. pmc Gain-of-function mutations in interleukin-7 receptor-α (IL7R) in childhood acute lymphoblastic leukemias
    Chen Shochat
    Childhood Leukemia Research Institute and Department of Pediatric Hemato Oncology, Sheba Medical Center, Tel Hashomer, Ramat Gan 52621, Israel
    J Exp Med 208:901-8. 2011
    Interleukin-7 receptor α (IL7R) is required for normal lymphoid development. Loss-of-function mutations in this gene cause autosomal recessive severe combined immune deficiency...
  42. doi The IL-7Rα pathway is quantitatively and functionally altered in CD8 T cells in multiple sclerosis
    Karim L Kreft
    Department of Neurology, Erasmus MC, University Medical Center, 3000 CA Rotterdam, The Netherlands
    J Immunol 188:1874-83. 2012
    ..This is of special interest in light of the established demyelinating and cytotoxic actions of granzyme A...
  43. doi IL-7 downregulates IL-7Rα expression in human CD8 T cells by two independent mechanisms
    Feras M Ghazawi
    Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
    Immunol Cell Biol 91:149-58. 2013
    ..It is therefore no surprise that expression of the IL-7 receptor alpha-chain (CD127) is tightly regulated...
  44. ncbi Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily
    R G Goodwin
    Immunex Corporation, Seattle, Washington 98101
    Cell 60:941-51. 1990
    ..Analysis of the sequence of the IL-7 receptor revealed significant homology in the extracellular domain to several recently cloned cytokine receptors, demonstrating that the IL-7 receptor is a member of a new receptor superfamily...
  45. ncbi IL-7R alpha gene expression is inversely correlated with cell cycle progression in IL-7-stimulated T lymphocytes
    Louise Swainson
    Centre National de la Recherche Scientifique, Unite Mixte de Recherche 5535, Montpellier, France
    J Immunol 176:6702-8. 2006
    ..Thus, IL-7 therapy should be designed to allow optimal responsiveness of naive and memory T cell subsets...
  46. ncbi Decreased CD127 expression on T Cells in HIV-1-infected adults receiving antiretroviral therapy with or without intermittent IL-2 therapy
    Sarah W Read
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Acquir Immune Defic Syndr 42:537-44. 2006
    ..We evaluated the IL-7/IL-7Ralpha system in a large cohort of HIV-infected patients, including a subset treated with intermittent IL-2...
  47. ncbi Interleukin-7 receptor expression on CD8 T-cells is downregulated by the HIV Tat protein
    Elliott M Faller
    Ottawa Health Research Institute, Ottawa, Ontario, Canada
    J Acquir Immune Defic Syndr 43:257-69. 2006
    We have previously shown decreased expression of the interleukin (IL)-7 receptor alpha-chain (CD127) on CD8 T-cells in HIV-infected patients and an apparent recovery of this receptor in those receiving antiretroviral therapy with ..
  48. ncbi Haplotypes of the interleukin 7 receptor alpha gene are correlated with altered expression in whole blood cells in multiple sclerosis
    F C McKay
    Westmead Millennium Institute, University of Sydney, Sydney, Australia
    Genes Immun 9:1-6. 2008
    IL7 regulates T cell survival, differentiation and proliferation. The alpha chain of its receptor, CD127, is polymorphic, and its haplotypes are associated with recovery from transplantation and with the autoimmune disease multiple ..
  49. pmc CD127 and CD25 expression defines CD4+ T cell subsets that are differentially depleted during HIV infection
    Richard M Dunham
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 180:5582-92. 2008
    ..into three subsets by the expression of receptors for two T cell-tropic cytokines, IL-2 (CD25) and IL-7 (CD127)...
  50. ncbi Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor
    M Noguchi
    Section on Pulmonary and Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892
    Science 262:1877-80. 1993
    ..These findings may help explain the defects of XSCID. Given its role in more than one cytokine receptor system, the common gamma chain (gamma c) is proposed as the designation for IL-2R gamma...
  51. ncbi Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/- mice
    E Maraskovsky
    Department of Cellular Immunology, Immunex Research and Development Corporation, Seattle, Washington 98101, USA
    Cell 89:1011-9. 1997
    ..These results provide evidence that blocking apoptosis is the essential function of IL-7R during differentiation and activation of T lymphocytes and that pre-TCR signaling blocks a pathway to apoptosis that is insensitive to Bcl-2...
  52. ncbi Interleukin 7 receptor alpha-chain-mutation severe combined immunodeficiency without lymphopenia: correction with haploidentical T-cell-depleted bone marrow transplantation
    Punita Ponda
    Division of Allergy and Immunology, Department of Pediatrics, Schneider Children s Hospital, North Shore Long Island Jewish Health System, Great Neck, New York 11021, USA
    Ann Allergy Asthma Immunol 97:755-8. 2006
    ..It often presents during the first year of life with recurrent, opportunistic infections, failure to thrive, and malabsorption...
  53. ncbi [A compound heterozygosity mutation in the interleukin-7 receptor-alpha gene resulted in severe combined immunodeficiency in a Chinese patient]
    Zhi Yong Zhang
    Department of Nephrology and Immunity, Children s Hospital, Chongqing Medical University, Chongqing 400014, China
    Zhonghua Er Ke Za Zhi 47:691-5. 2009
    ..Here we report the molecular and clinical characterization of a compound heterozygosity mutation in the interleukin-7 receptor-alpha gene that resulted in SCID in a patient firstly from China...
  54. ncbi Defective T-cell receptor gamma gene rearrangement in interleukin-7 receptor knockout mice
    S Candeias
    SAIC, NCI FCRDC, Frederick, MD 21702 1201, USA
    Immunol Lett 57:9-14. 1997
    ..These findings indicate that one or both of the two known ligands of IL-7R, IL-7 and thymic stromal lymphopoietin (TSLP) serves as an extrinsic signal to specifically rearrange the TCR gamma locus...
  55. pmc Interleukin 7 receptor control of T cell receptor gamma gene rearrangement: role of receptor-associated chains and locus accessibility
    S K Durum
    Laboratory of Molecular Immunoregulation, National Cancer Institute, Frederick, Maryland 21702, USA
    J Exp Med 188:2233-41. 1998
    ..This data supports the model that IL-7R promotes TCR-gamma gene rearrangement by regulating accessibility of the locus via demethylation and histone acetylation of the locus...
  56. doi Interleukin 7 receptor alpha chain haplotypes vary in their influence on multiple sclerosis susceptibility and response to interferon Beta
    Edwin Hoe
    Westmead Millennium Institute, University of Sydney, Australia
    J Interferon Cytokine Res 30:291-8. 2010
    b>Interleukin 7 receptor alpha chain (IL-7Ralpha) has recently been confirmed as the first non-HLA gene definitively associated with multiple sclerosis (MS)...
  57. ncbi Identification of 11 novel and common single nucleotide polymorphisms in the interleukin-7 receptor-alpha gene and their associations with multiple sclerosis
    Suzy M Teutsch
    Institute for Immunology and Allergy Research Westmead Millennium Institute, Westmead Hospital, Westmead, NSW 2145, Australia
    Eur J Hum Genet 11:509-15. 2003
    ..These polymorphisms would also be useful for studying genetic associations with other immunologic diseases...
  58. pmc Regulation of the interleukin-7 receptor alpha promoter by the Ets transcription factors PU.1 and GA-binding protein in developing B cells
    Rodney P DeKoter
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Biol Chem 282:14194-204. 2007
    ..consisting of a common gamma chain (gammac, encoded by Il2rg) and an alpha subunit (IL-7Ralpha, encoded by Il7r). The Il7r gene is expressed specifically in the immune system in a developmental stage-specific manner...
  59. ncbi Reduced numbers of IL-7 receptor (CD127) expressing immune cells and IL-7-signaling defects in peripheral blood from patients with breast cancer
    Nalini Kumar Vudattu
    Microbiology, Tumor and Cell Biology Center, Karolinska Institute, Solna, Sweden
    Int J Cancer 121:1512-9. 2007
    ..We studied IL-7Ralpha (CD127) expression in PBMCs obtained from patients with breast cancer and examined IL-7 receptor-mediated downstream ..
  60. ncbi Interleukin-7 is trophic for embryonic neurons and is expressed in developing brain
    M D Michaelson
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Dev Biol 179:251-63. 1996
    ..Expression of the mRNA encoding the high-affinity IL7 receptor (IL7R) is observed in vitro in neurons as well as in subventricular zone progenitor cells...
  61. ncbi A transgenic T cell receptor restores thymocyte differentiation in interleukin-7 receptor alpha chain-deficient mice
    T Crompton
    Imperial Cancer Research Fund, London, GB
    Eur J Immunol 27:100-4. 1997
    ..In contrast, once cells have progressed beyond the DN stage of development the IL-7R alpha chain becomes no longer essential for RAG expression...
  62. ncbi Distinct roles of the interleukin-7 receptor alpha chain in fetal and adult thymocyte development revealed by analysis of interleukin-7 receptor alpha-deficient mice
    T Crompton
    Department of Biology, Imperial College of Science, Technology and Medicine, London, GB
    Eur J Immunol 28:1859-66. 1998
    ..These data suggest that the IL-7Ralpha chain is a key regulator of both survival and proliferation during thymocyte development but that it is not essential for the production of T cells during fetal thymopoiesis...
  63. pmc Overlapping roles of CXCL13, interleukin 7 receptor alpha, and CCR7 ligands in lymph node development
    Sanjiv A Luther
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, 94143, USA
    J Exp Med 197:1191-8. 2003
    ..These findings indicate that CXCL13 and CCR7 ligands promote accumulation of CD4+ CD3- IL-7R alpha hi cells, delivering IL-7R alpha-dependent LT alpha 1 beta 2 signals critical for LN development...
  64. pmc Infection of CD127+ (interleukin-7 receptor+) CD4+ cells and overexpression of CTLA-4 are linked to loss of antigen-specific CD4 T cells during primary human immunodeficiency virus type 1 infection
    John J Zaunders
    Centre for Immunology, St Vincent s Hospital, Victoria Street, Darlinghurst, NSW 2010, Australia
    J Virol 80:10162-72. 2006
    ..However, a small subset of HIV-specific CD4+) T cells also expressed CD127, a marker of long-term memory cells...
  65. pmc Dual mechanism of impairment of interleukin-7 (IL-7) responses in human immunodeficiency virus infection: decreased IL-7 binding and abnormal activation of the JAK/STAT5 pathway
    Olivier Juffroy
    Institut Pasteur, Unité d Immunogénétique Cellulaire, 75724 Paris Cedex 15, France
    J Virol 84:96-108. 2010
    ..HIV infection differentially affected the expression of IL-7 receptor (IL-7R) chains, with decreases in IL-7Ralpha/CD127 expression in the memory subset and increases in gammac/CD132 expression in all CD4(+) T cells...
  66. ncbi Pre-pro-B cell growth-stimulating factor (PPBSF) upregulates IL-7Ralpha chain expression and enables pro-B cells to respond to monomeric IL-7
    Chiju Wei
    Department of Pathology, School of Medicine, University of Connecticut Health Center, Farmington, CT 06030 3105, USA
    J Interferon Cytokine Res 22:823-32. 2002
    ....
  67. ncbi IL-7 receptor is present on human microvascular endothelial cells
    Danuta Dus
    Laboratory of Cellular Interactions, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Centre of Excellence IMMUNE, R Weigla 12, 53 114, Wroclaw, Poland
    Immunol Lett 86:163-8. 2003
    ..The receptor consists of two chains: IL-7 specific alpha chain (CD127) and the common gamma(c) chain (CD132) which is a component of several other cytokine receptors: IL-2, IL-4, IL-9 ..
  68. ncbi GA binding protein regulates interleukin 7 receptor alpha-chain gene expression in T cells
    Hai Hui Xue
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 10, Room 7N252, Bethesda, Maryland 20892 1674, USA
    Nat Immunol 5:1036-44. 2004
    ....
  69. ncbi Loss of IL-7Ralpha is associated with CD4 T-cell depletion, high interleukin-7 levels and CD28 down-regulation in HIV infected patients
    Bence Rethi
    Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
    AIDS 19:2077-86. 2005
    ..The subset(s) of T cells with low IL-7Ralpha and the consequence of low IL-7Ralpha expression for T-cell survival are poorly characterized...
  70. pmc IL-7 receptor deficient SCID with a unique intronic mutation and post-transplant autoimmunity due to chronic GVHD
    Manish J Butte
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Clin Immunol 125:159-64. 2007
    ..Here we report a case of SCID due to heterozygous mutations of the IL7R gene encoding IL-7Ralpha...
  71. doi Characterisation and expression analysis of the chicken interleukin-7 receptor alpha chain
    Daphne A van Haarlem
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht, The Netherlands
    Dev Comp Immunol 33:1018-26. 2009
    ..Upon polyclonal stimulation with ConA, IL-7Ralpha was rapidly down-regulated on T cells, suggesting that in the chicken expression of this receptor might also be correlated to the T cell activation status...
  72. doi Effects of transmembrane and juxtamembrane domains on proliferative ability of TSLP receptor
    Jun Zhong
    McKusick Nathans Institute of Genetic Medicine, Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Immunol 47:1207-15. 2010
    ....
  73. pmc High content cellular immune profiling reveals differences between rhesus monkeys and men
    Isabelle Magalhaes
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Solna, Sweden
    Immunology 131:128-40. 2010
    ..This provides a matrix to assess future efforts to study diseases and vaccines in NHPs...
  74. pmc Increased numbers of IL-7 receptor molecules on CD4+CD25-CD107a+ T-cells in patients with autoimmune diseases affecting the central nervous system
    Nalini Kumar Vudattu
    Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 4:e6534. 2009
    ..High content immune profiling in peripheral blood may reflect immune aberrations associated with inflammation in multiple sclerosis (MS) and other autoimmune diseases affecting the central nervous system...
  75. doi Homeostatic cytokines and expansion of regulatory T cells accompany thymic impairment in children with Down syndrome
    Erika Roat
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
    Rejuvenation Res 11:573-83. 2008
    ..the proliferative T cell response to these cytokines, the expression of the alpha chain of the IL-7 receptor (CD127), the extrathymic differentiation of T lymphocytes, and the presence of natural regulatory T cells (Tregs) in ..
  76. ncbi IL-7 receptor alpha+ CD3(-) cells in the embryonic intestine induces the organizing center of Peyer's patches
    H Yoshida
    Department of Molecular Genetics, Faculty of Medicine, Institute of Genetics, Faculty of Medicine, Kyoto University, Syogoin Kawaharacho 53, Sakyoku, Kyoto 606 850, Japan
    Int Immunol 11:643-55. 1999
    ..0 d.p.c. (step II), and entry of CD3+ and B220+ lymphocytes just before birth (step III). PP formation of both Il7ra-/- and Lta-/- mice is impaired from step I, suggesting involvement of the two molecules at the same timing in PP ..
  77. ncbi Gastrointestinal cells of IL-7 receptor null mice exhibit increased sensitivity to irradiation
    L A Welniak
    Laboratory of Leukocyte Biology, Division of Basic Sciences, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, MD 21702, USA
    J Immunol 166:2924-8. 2001
    ..This study describes a novel role of IL-7 in nonhematopoietic tissues...
  78. pmc IL-7 receptor expression provides the potential for long-term survival of both CD62Lhigh central memory T cells and Th1 effector cells during Leishmania major infection
    Sara L Colpitts
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 182:5702-11. 2009
    ..whether the prosurvival cytokine IL-7 contributes to maintaining these T cells, we examined expression of the IL7R on CD4(+) T cells activated during L. major infection...
  79. pmc Patients with relapsing-remitting multiple sclerosis have normal Treg function when cells expressing IL-7 receptor alpha-chain are excluded from the analysis
    Laure Michel
    INSERM U643, CHU Nantes, Institut de Transplantation et de Recherche en Transplantation ITERT, and Faculté de Médecine, Universite de Nantes, Nantes, France
    J Clin Invest 118:3411-9. 2008
    ..function of this T cell subset in patients with MS, but we depleted cells expressing IL-7 receptor alpha-chain (CD127), a marker recently described as present on activated T cells but not Tregs...
  80. ncbi Requirement for stat5 in thymic stromal lymphopoietin-mediated signal transduction
    D E Isaksen
    Virginia Mason Research Center, Seattle, WA 98101, USA
    J Immunol 163:5971-7. 1999
    ..Moreover, TSLP-mediated signaling is inhibited by suppressor of cytokine signaling (SOCS)-1 and a kinase-deficient version of Tec but not by kinase-deficient forms of Jak1 and Jak2...
  81. pmc IL-7 receptor signaling is necessary for stage transition in adult B cell development through up-regulation of EBF
    Kazu Kikuchi
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Exp Med 201:1197-203. 2005
    ..Thus, IL-7 receptor signaling is a participant in the formation of the transcription factor network during B lymphopoiesis by up-regulating EBF, allowing stage transition from the pre-pro-B to further maturational stages...
  82. ncbi Transcriptional regulation of the mouse IL-7 receptor alpha promoter by glucocorticoid receptor
    Hai Chon Lee
    Laboratory of Biological Protection, Department of Biological Responses, Institute for Virus Research, Kyoto University, Kyoto, Japan
    J Immunol 174:7800-6. 2005
    ..Thus, this study identifies the IL-7Ralpha CNS-1 region as a GC-responsive element...
  83. pmc c-Myb is required for pro-B cell differentiation
    Shawn P Fahl
    Department of Microbiology, University of Virginia Health System, Charlottesville, VA 22908, USA
    J Immunol 183:5582-92. 2009
    ..survival of CD19(+) pro-B cells as well as the proper expression of the alpha-chain of the IL-7 receptor (CD127) and Ebf1...
  84. ncbi Cloning of a receptor subunit required for signaling by thymic stromal lymphopoietin
    A Pandey
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Nat Immunol 1:59-64. 2000
    ..Cloning of TSLPR should facilitate an understanding of TSLP function and its signaling mechanism...
  85. pmc Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells
    Adam S Lazorchak
    Department of Immunobiology, Yale School of Medicine, New Haven, CT 06519, USA
    Mol Cell 39:433-43. 2010
    ..Sin1 deficiency results in increased IL-7 receptor (il7r) and RAG recombinase (rag1 and rag2) gene expression, leading to enhanced pro-B cell survival and augmented V(D)J ..
  86. doi IL-7 receptor is expressed on adult pre-B-cell acute lymphoblastic leukemia and other B-cell derived neoplasms and correlates with expression of proliferation and survival markers
    Sarah C Sasson
    National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia
    Cytokine 50:58-68. 2010
    ..Surface expression of IL-7R components CD127 and CD132, and intracellular Ki-67 and Bcl-2 were examined by flow cytometry on peripheral blood or bone marrow ..
  87. doi Interleukin-4 downregulates CD127 expression and activity on human thymocytes and mature CD8+ T cells
    Angela M Crawley
    Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
    Eur J Immunol 40:1396-407. 2010
    Signaling via the IL-7 receptor complex (IL-7Ralpha/CD127 and IL-2Rgamma/CD132) is required for T-cell development and survival. Decreased CD127 expression has been associated with persistent viral infections (e.g. HIV, HCV) and cancer...
  88. ncbi Overexpression of IL-7R alpha provides a competitive advantage during early T-cell development
    Yasmina Laouar
    Section of Immunobiology, Yale University School of Medicine, 300 Ceda St, CAB S 569, New Haven, CT 06520, USA
    Blood 103:1985-94. 2004
    ..This advantage occurred at early stages of T-cell development. Our findings support the model that overexpression of growth factor receptors can contribute to proliferation and malignancy...
  89. ncbi STAT5 activation underlies IL7 receptor-dependent B cell development
    Christine A Goetz
    Department of Laboratory Medicine and Pathology, Center for Immunology, Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 172:4770-8. 2004
    Signals initiated by the IL7R are required for B cell development. However, the roles that distinct IL7R-induced signaling pathways play in this process remains unclear...
  90. ncbi Induction of the IL-7 receptor alpha chain in mouse peripheral B cells by glucocorticoids
    Hirofumi Shibata
    Laboratory of Biological Protection, Department of Biological Responses, Institute for Virus Research, Kyoto University, 53 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Immunol Lett 111:45-50. 2007
    ..Therefore, this study demonstrates that GCs induce the transcription and expression of functional IL-7R alpha in peripheral B cells, and implies a potential role of the IL-7R in survival of B cells...
  91. ncbi Antigen controls IL-7R alpha expression levels on CD8 T cells during full activation or tolerance induction
    Christopher D Hammerbeck
    Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
    J Immunol 180:2107-16. 2008
    The high-affinity chain of the IL-7 receptor, IL-7Ralpha (CD127), is expressed by effector CD8 T cells that have the capacity to become memory cells...
  92. doi Molecular cloning and expression analysis of CD127 in pig
    Yu Jin Hur
    Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea
    Anim Biotechnol 20:40-5. 2009
    b>CD127 (the alpha chain of the IL-7 receptor) is an 80 kDa type I membrane glycoprotein that mediates the signal for the differentiation, maturation, and survival of lymphocyte development...
  93. ncbi Impaired survival and proliferation in IL-7 receptor-deficient peripheral T cells
    E Maraskovsky
    Department of Cellular Immunology, Immunex Corporation, Seattle, WA 98101, USA
    J Immunol 157:5315-23. 1996
    ..We propose that an absence of IL-7R signaling not only affects T cell development in the thymus, but also results in the accumulation of functionally inactive T cells in the periphery...
  94. ncbi Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice
    K Akashi
    Department of Pathology, Stanford University School of Medicine, California 94305, USA
    Cell 89:1033-41. 1997
    ..We propose cell survival signals to be the principal function of IL-7R engagement in thymic and T cell development...
  95. ncbi Different cytokines induce surface lymphotoxin-alphabeta on IL-7 receptor-alpha cells that differentially engender lymph nodes and Peyer's patches
    Hisahiro Yoshida
    Division of Immunogenetics, Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Japan
    Immunity 17:823-33. 2002
    ..Soluble IL-7 administered to TRAF6(-/-) embryos was sufficient to restore LN genesis indicating the functional similarities of the IL-7R(alpha)(+) inducer cells for LN and PP genesis...
  96. ncbi IL-7/IL-7 receptor system regulation following IL-2 immunotherapy in HIV-infected patients
    Giulia Marchetti
    Institute of Infectious Diseases and Tropical Medicine, Luigi Sacco Hospital, University of Milan, Milan, Italy
    Antivir Ther 9:447-52. 2004
    ..Our data confirm the pivotal role of IL-2 and IL-7 in the regulation of T-lymphocyte homeostasis in HIV infection...
  97. ncbi Inherited disorders of cytokines
    Capucine Picard
    Unité d Immunologie et d Hématologie Pédiatriques, Hopital Necker Enfants Malades, and Laboratoire de Génétique Humaine des Maladies Infectieuses, Université de Paris René Descartes INSERM U550, Faculte de Medecine Necker, Paris, France
    Curr Opin Pediatr 16:648-58. 2004
    ..Cytokines are soluble mediators involved in the development or function of the immune system. This paper reviews the literature on childhood-onset inherited disorders associated with impaired cytokine-mediated immunity...
  98. ncbi IL-7R alpha versus CCR7 and CD45 as markers of virus-specific CD8+ T cell differentiation: contrasting pictures in blood and tonsillar lymphoid tissue
    D Sauce
    Cancer Research UK Institute for Cancer Studies, University of Birmingham, B15 2TT Birmingham, United Kingdom
    J Infect Dis 195:268-78. 2007
    ..As a discriminator between different virus-specific populations, IL-7R alpha therefore appears to be more susceptible to tissue location than the classical CCR7/CD45 markers...
  99. pmc Formation of IL-7Ralphahigh and IL-7Ralphalow CD8 T cells during infection is regulated by the opposing functions of GABPalpha and Gfi-1
    Anmol Chandele
    Department of Immunobiology, Yale Medical School, New Haven, CT 06511, USA
    J Immunol 180:5309-19. 2008
    ..for IL-7Ralpha expression in memory precursor effector cells, and this correlated with hyperacetylation of the Il7ra promoter...
  100. doi Loss of CD127 expression links immune activation and CD4(+) T cell loss in HIV infection
    Sandra A Koesters Kiazyk
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba R3E 0W3, Canada
    Trends Microbiol 16:567-73. 2008
    ..We propose that reduced expression of CD127 (IL-7 receptor alpha chain, IL-7Ralpha), induced by immune activation, contributes to CD4(+) T cell loss in HIV ..

Research Grants36

  1. Trophic Regulation in T Cell Homeostasis and Disease
    Jeffrey C Rathmell; Fiscal Year: 2010
    ..and intracellular trafficking by adoptive transfer of T cells into IL7-/- hosts and conditional deletion of IL7R in mature T cells. (2) Identify signaling mechanisms that regulate Glutl expression and cell surface localization...
  2. Regulation of memory CD8 T cell development
    Susan M Kaech; Fiscal Year: 2012
    ..abstract_text> ..
  3. Jennifer M Puck; Fiscal Year: 2014
    ..of humans with cytokine signaling pathway defects in the common g chain (gc) receptor, the IL-7 receptor a chain (IL7Ra), and Janus kinase 3 (Jak3), whereas the mouse knockouts lacking these proteins differ from humans in having T ..
  4. Molecular Recognition Studies of the Interleukin-7 Pathway
    SCOTT T WALSH; Fiscal Year: 2012
    ....
  5. Ming Li; Fiscal Year: 2014
    ..To determine the function of compromised CD127 (IL-7 receptor alpha chain) expression in TGF-beta receptor II-deficient thymocytes and naive T cells, a strain of ..
  6. IL7 AND IL7R TARGETED THERAPEUTIC AGENTS FOR LEUKEMIA
    John Murphy; Fiscal Year: 2000
    ..Thus, IL7(W143A) was the first IL7R antagonist to be reported...
  7. Benigno Rodriguez; Fiscal Year: 2016
    ..This is caused by IL-6 mediated inhibition of the IL-7 receptor [unreadable] chain - CD127 and IL-6-mediated activation of central memory CD4 T cell cycling and death...
  8. ROLE OF IL-7 IN DECREASED THYMOPOIESIS OF AGING
    Marilyn Thoman; Fiscal Year: 2006
    ..It is anticipated that these studies will lead to the development of strategies to enhance T lymphopoiesis and thereby improve immune function in the elderly as well as other immunodeficient adults. ..
  9. Immune Response to Cat: Regulatory and Effector T Cells
    Judith A Woodfolk; Fiscal Year: 2013
    ..Low expression of CD127 (IL-7R 1 chain) will be used to isolate natural (CD25+CD127lo) and adaptive (CD25negCD127lo) Tregs from AD ..
  10. MARKUS MUSCHEN; Fiscal Year: 2015
    ..In preliminary work for this proposal, we found that IL7R?/Stat5/Akt signaling is critical to keep normal pre-B cells in an antigen- unresponsive state...
  11. Defining the Functional Role of a Novel MS Susceptibility Gene, IL7R alpha chain
    Simon G Gregory; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Defining the functional role of a novel MS susceptibility gene, IL7R alpha chain...
  12. Development of Intestinal Immune Regulation in Human Infants
    JOERN HENDRIK WEITKAMP; Fiscal Year: 2013
    ..characterized as interleukin-2 receptor a (IL-2Ra = CD25)''"3'''CD4^ CD45RO* IL-7R (CD127)*"'T cells expressing high levels of the transcription factor forkhead box protein 3 (FOXPS)...
  13. UTPAL P DAVE; Fiscal Year: 2016
    ..tyrosine kinase that binds with IL2RG to transduce signals from multiple cytokine receptors (IL2R, IL4R, IL7R, IL9R, IL15R, and IL21R) upon ligand binding...
  14. T Cell Homeostasis in Systemic Autoimmunity
    Argyrios N Theofilopoulos; Fiscal Year: 2012
    ..that the highly expanded double-negative (DN) CD4[unreadable]CD8[unreadable] T cells do not express IL- 7R (CD127) or IL-15R (CD122)...
  15. TSLP AND LYMPHOPOIESIS
    Andrew Farr; Fiscal Year: 2003
    ..Third, because of preliminary data indicating that the IL7R contributes to the functional TSLP receptor, the hypothesis that the action of TSLP, which is highly expressed in ..
  16. REGULATION OF V(D)J RECOMBINATION IN B CELL DEVELOPMENT
    Rachel M Gerstein; Fiscal Year: 2011
    ..Specific Aim 1 is to determine the mechanism by the IL7R:JAK3:pSTAT5 pathway regulates the V(D)J recombinase...
  17. Prime/Boost Vaccine to Prevent Hepatocellular Carcinoma
    JOHN HAYWARD ELDRIDGE; Fiscal Year: 2012
    ..Second, IL-12 is known to up regulate CD28 and CD127 expression on T cells and to be a potent inhibitor of tolerance induction...
  18. Mechanisms of Immune Evasion by Hepatitis C Virus
    Andrea L Cox; Fiscal Year: 2012
    ..clear HCV infection and those who progress to chronic infection 2) test the hypothesis that expression of PD-1 and CD127 affects the function of CD8 T cells specific for non-mutated HCV epitopes and evaluate mechanisms of regulation of ..
  19. Mechanisms of tolerance in recipients of combined kidney and bone marrow transpla
    Megan Sykes; Fiscal Year: 2010
    ..of the development of anti-donor antibodies;and 2) Assess the role of regulatory cells, including FoxP3+ Treg and CD127-C025-C04 cells, in the development of donor-specific tolerance in recipients of CKBMT...
  20. Comparison of B Cell Differentiation in Mice and Humans
    MAX DALE COOPER; Fiscal Year: 2010
    ..and dominant-negative transgenes, and (iv) examine the effects of ligating cell surface receptors (preBCR, BCR, IL7R, CD19, CD32, and CD40) on growth and differentiation of these B lineage cells...
  21. IFN-a and pDC in HIV infection: impact on T cell development and reconstitution
    Christel H Uittenbogaart; Fiscal Year: 2013
    ..show that HIV-1-induced IFN-?? production inhibits early stages of human T cell development by impairing the IL-7/IL7R pathway...
  22. Genetic Epidemiology of Multiple Sclerosis
    Jonathan L Haines; Fiscal Year: 2010
    ..new genetic association in MS in over 30 years;we demonstrated that a common non-synonymous functional SNP in the IL7RA gene was associated with an increased risk of MS...
  23. Regulation of B Cell Development by Ras and Raf
    Michael Farrar; Fiscal Year: 2002
    ..Thus the aims of this application are: (1) To determine whether the IL7R or flk2/flt3 entrain early B cell development via Ras activation, (2) To determine whether Ras/Raf-dependent early ..
  24. Innate and adaptive immunity in children starting anir*
    Savita Pahwa; Fiscal Year: 2007
    ..The nadir of NaTve CD4 T cells prior to starting ART predicts capacity for CD4 T Cell reconstitution; 2. Loss of CD127+ CDS T Cells or expansion of CD127-CD8 T Cells is associated with aberrant immune activation and disease ..
  25. Epidemiology of Regulatory T Cells in Pregnancy and Childhood Atopic Diseases
    Ganesa Wegienka; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  26. Memory CD8 T cell subset cooperation via chemokines in protective immunity to inf
    E Wherry; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  27. Pathogen-specific T cell responses in patients with SLE
    Insoo Kang; Fiscal Year: 2008
    ..abstract_text> ..
  28. Investigating aging and membrane-associated T cell receptor signaling in human CD
    Insoo Kang; Fiscal Year: 2008
    ..Recently, my lab measured expression of IL-7 receptor alpha chain (IL-7Ra, CD127) which dictates the response to IL-7, a cytokine critical for T cell homeostasis, on CD8+ T cells in young and ..
  29. MVA/HIV-48: Potential Dual Vaccine for HIV and Smallpox
    Rama Rao Amara; Fiscal Year: 2003
    ..The project will be a collaborative undertaking between researchers at the CDC, the NIAID, and the NIAID HIV Vaccine Trial Network (HVTN ). The focus of this application is the quantification and phenotyping of responding T cells. ..
  30. Roles of Nod2 in the Pathogenesis of Crohn's Disease
    Richard Flavell; Fiscal Year: 2008
    ..Furthermore, by using mice in which Rip2, the kinase downstream of Nod2, is deficient, we will try to reveal if the IBD pathology caused by Nod2 mutation is dependent on Rip2. [unreadable] [unreadable]..
  31. The Role of IL-2 in Autoimmune Diabetes
    Richard Flavell; Fiscal Year: 2007
    ..We will utilize our IL-2 knock-in mice to test these two mutually nonexclusive hypotheses. ..
  32. Vaccine responsiveness to Borrelia burgdorferi OspA
    Richard Flavell; Fiscal Year: 2007
    ..abstract_text> ..
  33. TOLERANCE OF ISLET CELL GRAFT
    Jeffrey Bluestone; Fiscal Year: 2001
    ..The outcome of these studies will have important implications for islet cell transplantation for the treatment of IDDM. ..
  34. Dys/Regulation of the Immune System in Autoimmunity
    Richard Flavell; Fiscal Year: 2006
    ..The program is coordinated by frequent meetings of the program faculty and research workers bringing together these diverse approaches to address a common goal. ..
  35. Immunomodulation in Multiple Sclerosis by Interferon B
    Jorge Oksenberg; Fiscal Year: 2005
    ..In addition to new insights into the fundamental biology of interferons, our results will potentially identify surrogate markers of activity, and define the molecular basis of interferon response heterogeneity. ..