IL37

Summary

Gene Symbol: IL37
Description: interleukin 37
Alias: FIL1, FIL1(ZETA), FIL1Z, IL-1F7, IL-1H, IL-1H4, IL-1RP1, IL-37, IL1F7, IL1H4, IL1RP1, interleukin-37, FIL1 zeta, IL-1 zeta, IL-1F7b (IL-1H4, IL-1H, IL-1RP1), IL-1X protein, IL1F7 (canonical product IL-1F7b), interleukin 1 family member 7, interleukin 1, zeta, interleukin-1 homolog 4, interleukin-1 superfamily z, interleukin-1-related protein, interleukin-23
Species: human

Top Publications

  1. ncbi Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2
    R Debets
    DNAX Research Institute of Molecular and Cellular Biology, 901 California Avenue, Palo Alto, CA 94304, USA
    J Immunol 167:1440-6. 2001
  2. ncbi A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes
    M J Nicklin
    Department of Medicine and Pharmacology, University of Sheffield, Royal Hallamshire Hospital, United Kingdom
    Genomics 19:382-4. 1994
  3. ncbi IL1HY1: A novel interleukin-1 receptor antagonist gene
    J J Mulero
    Functional Genomics Department, Immunology Group, Hyseq Inc, 670 Almanor Avenue, Sunnyvale, California 94086, USA
    Biochem Biophys Res Commun 263:702-6. 1999
  4. pmc IL-37 is a fundamental inhibitor of innate immunity
    Marcel F Nold
    Department of Medicine, University of Colorado Denver, Aurora, Colorado, USA
    Nat Immunol 11:1014-22. 2010
  5. pmc Interleukin 37 expression protects mice from colitis
    Eoin N McNamee
    Department of Medicine, Section of Pediatric Gastroenterology, Digestive Health Institute, Children s Hospital Colorado, University of Colorado Denver, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 108:16711-6. 2011
  6. pmc Interleukin-37 reduces liver inflammatory injury via effects on hepatocytes and non-parenchymal cells
    Nozomu Sakai
    Department of Surgery, University of Cincinnati, Cincinnati, Ohio, USA
    J Gastroenterol Hepatol 27:1609-16. 2012
  7. ncbi Four new members expand the interleukin-1 superfamily
    D E Smith
    Immunex Corp, Seattle, Washington 98101, USA
    J Biol Chem 275:1169-75. 2000
  8. ncbi Identification and initial characterization of four novel members of the interleukin-1 family
    S Kumar
    Department of Bone and Cartilage Biology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    J Biol Chem 275:10308-14. 2000
  9. ncbi Proteomics-based identification of proteins interacting with Smad3: SREBP-2 forms a complex with Smad3 and inhibits its transcriptional activity
    Susanne Grimsby
    Ludwig Institute for Cancer Research, Box 595, BMC, SE 751 24, Uppsala, Sweden
    FEBS Lett 577:93-100. 2004
  10. ncbi IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp
    G Pan
    Department of Endocrinology, Genentech, Inc, 1 DNA Way, South San Francisco, CA, 94080, USA
    Cytokine 13:1-7. 2001

Research Grants

  1. CHARLES ANTHONY DINARELLO; Fiscal Year: 2014

Scientific Experts

  • Tsung Chieh Yao
  • Jing Du
  • Liping Xia
  • Peizeng Yang
  • C Haas
  • Diana Boraschi
  • Kati Hanhineva
  • P Rahman
  • Tae Hwan Kim
  • Patrick Van Dijck
  • Martin J H Nicklin
  • Philip Bufler
  • S J Busfield
  • G Pan
  • S Kumar
  • Charles A Dinarello
  • Marcel F Nold
  • CHARLES ANTHONY DINARELLO
  • Bingni Chen
  • Yanqun Li
  • Claudia A Nold-Petry
  • Ina Rudloff
  • Kunwu Yu
  • P Conti
  • Qingwei Ji
  • Liang Ye
  • Zhong Huang
  • Jinshun Zhang
  • Alexander R Moschen
  • Rihab Charrad
  • Areum Kwak
  • Yu Hua Chen
  • Jian Fa Jiang
  • Guanqun Ge
  • Agnes Hamzaoui
  • Jason C Lao
  • Steven X Cho
  • Kamel Hamzaoui
  • Yingzhong Lin
  • Junai Zhang
  • Qiutang Zeng
  • Tianshu Yang
  • Lars Lunding
  • L Lunding
  • Soohyun Kim
  • Jiajie Gu
  • Jesper F Højen
  • Ying Huang
  • Kai Meng
  • Eya Bouali
  • Rithee Smithrithee
  • Z Huang
  • Xu Shuai
  • Lingge He
  • Kunzhao Huang
  • Suzhao Li
  • A Caraffa
  • Ping wei Zhao
  • Dov B Ballak
  • Ting Yu
  • Z Ye
  • Nazar Sharaf
  • Zhong Yuan Wan
  • Cong Li
  • Catarina A B Rodrigues
  • B Pei
  • Ralf Ross
  • H Imaeda
  • Herbert Tilg
  • S Tete
  • Nozomu Sakai
  • Cecilia Garlanda
  • Alberto Mantovani
  • Regina T Chustz
  • Rui Ge
  • Eoin N McNamee
  • P Muhr
  • Cristina R Vianna
  • M Y Jung
  • H E Barksby
  • Sheetal Sharma
  • Mark N Pinkerton
  • Ceire Costelloe
  • Johan M Thevelein
  • H Lin
  • J E Sims
  • D E Smith
  • J E Ford
  • J L Barton
  • J J Mulero

Detail Information

Publications80

  1. ncbi Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2
    R Debets
    DNAX Research Institute of Molecular and Cellular Biology, 901 California Avenue, Palo Alto, CA 94304, USA
    J Immunol 167:1440-6. 2001
    ....
  2. ncbi A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes
    M J Nicklin
    Department of Medicine and Pharmacology, University of Sheffield, Royal Hallamshire Hospital, United Kingdom
    Genomics 19:382-4. 1994
    ..Relative to one terminal CpG island, the three genes were mapped to the following intervals: IL1A was between +0 and +35 kb, IL1B was between +70 and +110 kb, and IL1RN was between +330 and +430 kb...
  3. ncbi IL1HY1: A novel interleukin-1 receptor antagonist gene
    J J Mulero
    Functional Genomics Department, Immunology Group, Hyseq Inc, 670 Almanor Avenue, Sunnyvale, California 94086, USA
    Biochem Biophys Res Commun 263:702-6. 1999
    ..Furthermore, the message can be induced in THP-1 cells by phorbol ester (PMA) and lipopolysaccharide (LPS) treatment...
  4. pmc IL-37 is a fundamental inhibitor of innate immunity
    Marcel F Nold
    Department of Medicine, University of Colorado Denver, Aurora, Colorado, USA
    Nat Immunol 11:1014-22. 2010
    The function of interleukin 37 (IL-37; formerly IL-1 family member 7) has remained elusive...
  5. pmc Interleukin 37 expression protects mice from colitis
    Eoin N McNamee
    Department of Medicine, Section of Pediatric Gastroenterology, Digestive Health Institute, Children s Hospital Colorado, University of Colorado Denver, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 108:16711-6. 2011
    ..Thus, IL-37 emerges as key modulator of intestinal inflammation...
  6. pmc Interleukin-37 reduces liver inflammatory injury via effects on hepatocytes and non-parenchymal cells
    Nozomu Sakai
    Department of Surgery, University of Cincinnati, Cincinnati, Ohio, USA
    J Gastroenterol Hepatol 27:1609-16. 2012
    ..The purpose of the present study was to determine the effects of interleukin-37 (IL-37) on liver cells and on liver inflammation induced by hepatic ischemia/reperfusion (I/R)...
  7. ncbi Four new members expand the interleukin-1 superfamily
    D E Smith
    Immunex Corp, Seattle, Washington 98101, USA
    J Biol Chem 275:1169-75. 2000
    ..of four new members of the interleukin-1 (IL-1) family (FIL1delta, FIL1epsilon, FIL1zeta, and FIL1eta, with FIL1 standing for "Family of IL-1")...
  8. ncbi Identification and initial characterization of four novel members of the interleukin-1 family
    S Kumar
    Department of Bone and Cartilage Biology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    J Biol Chem 275:10308-14. 2000
    ..This suggests that IL-1H1 may be involved in pathogenesis of immune mediated disease processes. The addition of four novel IL-1 homologues suggests that the IL-1 family is significantly larger than previously thought...
  9. ncbi Proteomics-based identification of proteins interacting with Smad3: SREBP-2 forms a complex with Smad3 and inhibits its transcriptional activity
    Susanne Grimsby
    Ludwig Institute for Cancer Research, Box 595, BMC, SE 751 24, Uppsala, Sweden
    FEBS Lett 577:93-100. 2004
    ..We found that SREBP-2 inhibited the transcriptional activity of Smad3 in luciferase reporter assays...
  10. ncbi IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp
    G Pan
    Department of Endocrinology, Genentech, Inc, 1 DNA Way, South San Francisco, CA, 94080, USA
    Cytokine 13:1-7. 2001
    ..These findings suggest that IL-1H may be another ligand for the IL-18 receptor and a new player in the inflammatory and immune responses mediated by the IL-18/IL-18R axis...
  11. pmc Downregulated interleukin 37 expression associated with aggravation of intervertebral disc degeneration
    Zhong Yuan Wan
    Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University Xi an, Shaanxi, P R China
    Int J Clin Exp Pathol 7:656-62. 2014
    b>Interleukin 37 (IL-37) is an anti-inflammatory cytokine which was proven to be associated with several diseases characterized with excessive-inflammation...
  12. ncbi Interleukin-1F7B (IL-1H4/IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma production
    Sanjay Kumar
    Musculoskeletal Diseases, GlaxoSmithKline, 709 Swedeland Road, King of Prussia, PA, 19406, USA
    Cytokine 18:61-71. 2002
    ..Finally, we have localized the expression of IL-1F7b protein in discrete cell populations including plasma cells and tumor cells. These data suggest that IL-1F7b may be involved in immune response, inflammatory diseases and/or cancer...
  13. ncbi The IL-1 family member 7b translocates to the nucleus and down-regulates proinflammatory cytokines
    Sheetal Sharma
    Children s Hospital, Ludwig Maximilians University, Munich, Germany
    J Immunol 180:5477-82. 2008
    ....
  14. pmc Epithelial expression of interleukin-37b in inflammatory bowel disease
    H Imaeda
    Department of Medicine, Shiga University of Medical Science, Otsu, Japan
    Clin Exp Immunol 172:410-6. 2013
    ..Epithelial IL-37b expression was increased in IBD patients, especially UC patients. IL-37b may be involved in the pathophysiology of IBD as an anti-inflammatory cytokine and an inhibitor of both innate and acquired immune responses...
  15. pmc Serum interleukin-37 concentrations and HBeAg seroconversion in chronic HBV patients during telbivudine treatment
    Cong Li
    1 Department of Central Laboratory, the Second Part of First Hospital, Jilin University, Changchun, China
    J Interferon Cytokine Res 33:612-8. 2013
    ..These results suggest that IL-37 may play a significant role in the immune response of CHB patients with HBeAg seroconversion. The serum levels of IL-37 are associated with liver damage in CHB patients. ..
  16. pmc A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity
    Philip Bufler
    University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 99:13723-8. 2002
    ..We propose that after binding to IL-18BP, IL-1F7b forms a complex with IL-18Rbeta, depriving the beta-chain of forming a functional receptor complex with IL-18Ralpha and thus inhibiting IL-18 activity...
  17. pmc IL-37 inhibits the production of inflammatory cytokines in peripheral blood mononuclear cells of patients with systemic lupus erythematosus: its correlation with disease activity
    Liang Ye
    Biological Therapy Institute, Shenzhen University School of Medicine, 518060 Shenzhen, China
    J Transl Med 12:69. 2014
    ....
  18. ncbi Identification and gene organization of three novel members of the IL-1 family on human chromosome 2
    S J Busfield
    Millennium Pharmaceuticals Inc, 640 Memorial Drive, Cambridge, Massachusetts, 02139, USA
    Genomics 66:213-6. 2000
    ..These genes may prove to have an important role in inflammatory responses...
  19. ncbi Genomic organization of the interleukin-1 locus
    Scott L Taylor
    Immunex Corporation, 51 University Street, Seattle, Washington 98101, USA
    Genomics 79:726-33. 2002
    ..There is a break in the mouse locus of > 100 kb, compared with the human locus, located between Il1b and the most centromere-proximal of the novel mouse genes. The mouse seems to be missing an ortholog of human IL1F7.
  20. ncbi Innate immunity mediated by the cytokine IL-1 homologue 4 (IL-1H4/IL-1F7) induces IL-12-dependent adaptive and profound antitumor immunity
    Wentao Gao
    Department of Molecular Genetics, University of Pittsburgh, PA 15219, USA
    J Immunol 170:107-13. 2003
    ..These results suggest that IL-1H4 could play an important role in the link between innate and adaptive immunity and may be useful for tumor immunotherapy...
  21. doi IL-37 requires IL-18Rα and SIGIRR/IL-1R8 to diminish allergic airway inflammation in mice
    L Lunding
    Division of Asthma Mouse Models, Priority Area Asthma and Allergy, Research Center Borstel, Airway Research Center North, Member of the German Center for Lung Research, Borstel, Germany
    Allergy 70:366-73. 2015
    ..This study aimed to investigate the effects of IL-37 on allergic airway inflammation in a mouse model of experimental asthma...
  22. pmc Increased expression of IL-37 in patients with Graves' disease and its contribution to suppression of proinflammatory cytokines production in peripheral blood mononuclear cells
    Yanqun Li
    Biological Therapy Institute, Shenzhen University School of Medicine, Shenzhen, China Department of Pathogen Biology and Immunology, Shenzhen University School of Medicine, Shenzhen, China Shenzhen City Shenzhen University Immunodiagnostic Technology Platforms, Shenzhen, China
    PLoS ONE 9:e107183. 2014
    ..Furthermore, we investigate the effect of IL-37 on proinflammatory cytokines involved in the pathogenesis of GD...
  23. pmc Interleukin-37 is increased in ankylosing spondylitis patients and associated with disease activity
    Bingni Chen
    Biological Therapy Institute, Shenzhen University School of Medicine, Shenzhen, 518060, Guangdong, China
    J Transl Med 13:36. 2015
    ..Here, we examined the serum levels of IL-37 and its clinical association in AS, and explored the anti-inflammatory effects of IL-37 on peripheral blood mononuclear cells (PBMCs) from AS patients...
  24. pmc Adipose and liver expression of interleukin (IL)-1 family members in morbid obesity and effects of weight loss
    Alexander R Moschen
    Christian Doppler Research Laboratory for Gut Inflammation, Medical University Innsbruck, Innsbruck, Austria
    Mol Med 17:840-5. 2011
    ..Excessive weight loss changes the adipose and liver expression profile of IL-1F members toward a more antiinflammatory direction...
  25. doi RNA/DNA co-analysis from human skin and contact traces--results of a sixth collaborative EDNAP exercise
    C Haas
    Institut fur Rechtsmedizin, Universitat Zurich, Switzerland Electronic address
    Forensic Sci Int Genet 16:139-47. 2015
    ..Two sets of previously described skin-specific markers were used: skin1 pentaplex (LCE1C, LCE1D, LCE2D, IL1F7 and CCL27) and skin2 triplex (LOR, KRT9 and CDSN) in conjunction with a housekeeping gene, HKG, triplex (B2M, UBC ..
  26. doi IL-37 protects against obesity-induced inflammation and insulin resistance
    Dov B Ballak
    Department of Medicine, Radboud University Medical Centre, Geert Grooteplein 8, P O Box 9101, Nijmegen 6500 HB, The Netherlands
    Nat Commun 5:4711. 2014
    ....
  27. doi High-level expression and one-step purification of a soluble recombinant human interleukin-37b in Escherichia coli
    Jiajie Gu
    Department of Immunology, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University School of Medicine, Ningbo 315211, China
    Protein Expr Purif 108:18-22. 2015
    ..Thus, this method provides an efficient way to obtain an active IL-37 with high yield and high purity. ..
  28. pmc Plasma levels of IL-37 and correlation with TNF-α, IL-17A, and disease activity during DMARD treatment of rheumatoid arthritis
    Ping wei Zhao
    Key Laboratory of Zoonosis Research, Ministry of Education, The First Hospital, Jilin University, Changchun, China
    PLoS ONE 9:e95346. 2014
    ..IL-37 expression in RA and during DMARD treatment appears to be controlled by the level of pro-inflammatory cytokines. This results in a strong correlation between plasma levels of IL-37 and disease activity in RA patients. ..
  29. doi Long-range DNA interactions at the IL-1/IL-36/IL-37 gene cluster (2q13) are induced by activation of monocytes
    Nazar Sharaf
    Dept Immunity and Infection, University of Sheffield School of Medicine, Beech Hill Road, Sheffield S10 2RX, United Kingdom
    Cytokine 68:16-22. 2014
    ..These include agonists and antagonists of the parallel IL-1 and IL-36 systems, and IL1F7, the gene encoding IL-37...
  30. pmc Elevated plasma IL-37, IL-18, and IL-18BP concentrations in patients with acute coronary syndrome
    Qingwei Ji
    Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China Department of Cardiology, The People s Hospital of Guangxi Zhuang Autonomous Region, Nanning, China
    Mediators Inflamm 2014:165742. 2014
    ..However, the plasma levels of IL-37 in patients with acute coronary syndrome (ACS, including unstable angina pectoris and acute myocardial infarction) have yet to be investigated...
  31. doi Human β-defensin-3 increases the expression of interleukin-37 through CCR6 in human keratinocytes
    Rithee Smithrithee
    Atopy Allergy Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan Department of Dermatology and Allergology, Juntendo University Graduate School of Medicine, Tokyo, Japan
    J Dermatol Sci 77:46-53. 2015
    ..Although hBDs enhance the production of cytokines, including IL-1 cytokines, whether they stimulate the production of IL-37 remains unclear...
  32. ncbi A possible role for interleukin 37 in the pathogenesis of Behcet's disease
    Z Ye
    The First Affiliated Hospital of Chongqing Medical University, Youyi Road 1, Chongqing, 400016, P R China
    Curr Mol Med 14:535-42. 2014
    b>Interleukin 37 has been found to play a significant regulatory role in the innate immune response...
  33. pmc Genome-wide association study of lung function phenotypes in a founder population
    Tsung Chieh Yao
    Department of Human Genetics, University of Chicago, Chicago, Ill Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan Electronic address
    J Allergy Clin Immunol 133:248-55.e1-10. 2014
    ..Lung function is a long-term predictor of mortality and morbidity...
  34. pmc Modulation of IL-37 expression by triptolide and triptonide in THP-1 cells
    Lingge He
    Key Laboratory for Medical Molecular Diagnostic of Guangdong Province, Guangdong Medical College, Dongguan, China
    Cell Mol Immunol 12:515-8. 2015
    ..Cellular & Molecular Immunology advance online publication, 6 October 2014; doi:10.1038/cmi.2014.92. ..
  35. doi Allergic airway inflammation: unravelling the relationship between IL-37, IL-18Rα and Tir8/SIGIRR
    Lars Lunding
    a Division of Asthma Mouse Models, Priority Area Asthma and Allergy, Research Center Borstel, Airway Research Center North, Member of the German Center for Lung Research, Borstel, Germany
    Expert Rev Respir Med 9:739-50. 2015
    ..This article reviews the functions of these IL-1 cytokine family members in the regulation of allergic airway inflammation and asthma as they have been assessed clinically, in vitro and in mouse models. ..
  36. doi IL-37 a New IL-1 Family Member Emerges as a Key Suppressor of Asthma Mediated by Mast Cells
    P Conti
    a Immunology Division, Postgraduate Medical School, University of Chieti Pescara, Chieti, Italy
    Immunol Invest . 2016
    ..IL-37 has an impact on inflammatory cytokines generated by mast cells and is beneficial for and protective in asthma. However, the precise mechanism(s), safety, and tolerability of IL-37 are unclear and still remain a mystery...
  37. ncbi Monocytes and dendritic cells are the primary sources of interleukin 37 in human immune cells
    Ina Rudloff
    Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Victoria, Australia
    J Leukoc Biol . 2016
    ..In PBMCs stimulated with agonists of Toll-like receptors (TLRs) 1-6 and 9, IL1F7 (the IL-37-encoding gene) was induced up to 9-fold, peaked at 6-8 h and returned to steady-state at 72 h...
  38. ncbi Intracellular interleukin (IL)-1 family cytokine processing enzyme
    Areum Kwak
    Laboratory of Cytokine Immunology, Department of Biomedical Science and Technology, Konkuk University, 120 Neungdong ro, Gwangjin gu, Seoul, 05029, Korea
    Arch Pharm Res 39:1556-1564. 2016
    ..In this review, we describe all eleven IL-1 family ligand processing enzymes, mature ligand functions, and mode of receptor conformation...
  39. doi CCL22 and IL-37 inhibit the proliferation and epithelial-mesenchymal transition process of NSCLC A549 cells
    Yu Hua Chen
    Department of Clinical Laboratory, Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong 524001, P R China
    Oncol Rep 36:2017-24. 2016
    ..05). CCL22 and IL-37 with a co-localization in the A549 cells inhibited the proliferation and EMT process in A549 cells. The antitumor effects of CCL22 and IL37 provide a strategy for the treatment of NSCLC.
  40. doi Increased IL-37 concentrations in patients with arterial calcification
    Kunwu Yu
    Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Clin Chim Acta 461:19-24. 2016
    ..However, whether IL-37 concentrations are significantly changed in patients with arterial calcification has not yet been investigated...
  41. ncbi A tissue specific IL-1 receptor antagonist homolog from the IL-1 cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities
    J L Barton
    Division of Molecular and Genetic Medicine, University of Sheffield, Sheffield, GB
    Eur J Immunol 30:3299-308. 2000
    ..We conclude, contrary to a recent suggestion made by others, that IL-1L1 is not a functional IL-1ra. IL-1L1 also had no detectable agonistic or antagonistic effect on IFN-gamma production in response to IL-18 in KG-1 cells...
  42. ncbi Cloning and characterization of IL-1HY2, a novel interleukin-1 family member
    H Lin
    Functional Genomics Department, Hyseq Inc, Sunnyvale, California 94086, USA
    J Biol Chem 276:20597-602. 2001
    ..These data suggest that IL-1HY2 is a novel IL-1 family member and that it may participate in a network of IL-1 family members to regulate adapted and innate immune responses...
  43. ncbi A new nomenclature for IL-1-family genes
    J E Sims
    Trends Immunol 22:536-7. 2001
  44. ncbi A sequence-based map of the nine genes of the human interleukin-1 cluster
    Martin J H Nicklin
    Division of Genomic Medicine, University of Sheffield, Royal Hallamshire Hospital, Sheffield S10 2JF, UK
    Genomics 79:718-25. 2002
    ..Gene order from centromere to telomere is IL1A-IL1B-IL1F7-IL1F9-IL1F6-IL1F8-IL1F5-IL1F10-IL1RN, of which only IL1A, IL1B, and IL1F8 are transcribed towards the centromere...
  45. pmc Interleukin-37 suppresses tumor growth through inhibition of angiogenesis in non-small cell lung cancer
    Guanqun Ge
    Department of Surgical Oncology, The First Affiliated Hospital of Xi an Jiaotong University, 277, Yantaxi Road, Xi an, 710061, Shaanxi, China
    J Exp Clin Cancer Res 35:13. 2016
    ....
  46. doi IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction
    Claudia A Nold-Petry
    1 Ritchie Centre, MIMR PHI Institute of Medical Research, Melbourne, Victoria, Australia 2 Department of Paediatrics, Monash University, Melbourne, Australia
    Nat Immunol 16:354-65. 2015
    b>Interleukin 37 (IL-37) and IL-1R8 (SIGIRR or TIR8) are anti-inflammatory orphan members of the IL-1 ligand family and IL-1 receptor family, respectively...
  47. doi IL-37 Is a Novel Proangiogenic Factor of Developmental and Pathological Angiogenesis
    Tianshu Yang
    From the Shanghai Tenth People s Hospital, Tongji University School of Medicine, Shanghai, China T Y, Q L, M Z, Y H, R W, X Z, G X, J Y, S B S Johns Hopkins University School of Medicine, Baltimore, MD Q L, X Y State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China Y Y, J J, H Z, X H, S B S, X L Department of Ophthalmology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China G L, P L Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX D B C and Department of Stomatology, Huashan Hospital, Fudan University, Shanghai, China S L
    Arterioscler Thromb Vasc Biol 35:2638-46. 2015
    Angiogenesis is tightly controlled by growth factors and cytokines in pathophysiological settings. Interleukin 37 (IL-37) is a newly identified cytokine of the IL-1 family, some members of which are important in inflammation and ..
  48. doi Anti-inflammatory activity of IL-37 in asthmatic children: Correlation with inflammatory cytokines TNF-α, IL-β, IL-6 and IL-17A
    Rihab Charrad
    Unit Research 12SP15 Homeostasis and Cell Dysfunction, Abderrahman Mami Hospital, Ariana, Tunisia El Manar Tunis University, Faculty of Medicine of Tunis, Department of Basic Sciences, Tunis, Tunisia
    Immunobiology 221:182-7. 2016
    ..The aim of this study was to assess interleukin (IL)-37 production in asthmatic children in serum and induced sputum and to look to the impact of IL-37 on pro-inflammatory cytokines production (TNF-α, IL-6, IL-1β and IL-17)...
  49. pmc Expression of IL-37 contributes to the immunosuppressive property of human CD4+CD25+ regulatory T cells
    Xu Shuai
    Trauma Research Center, First Hospital Affiliated to the Chinese PLA General Hospital, Beijing 100048, China
    Sci Rep 5:14478. 2015
    ..These results demonstrated that IL-37 might manifest as a critical protein involving in immunosuppression of human CD4(+)CD25(+)Tregs. ..
  50. doi Increased Expression of Interleukin 37 in the Eutopic and Ectopic Endometrium of Patients With Ovarian Endometriosis
    Jian Fa Jiang
    Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
    Reprod Sci 23:244-8. 2016
    ..This study investigated the gene and protein expression of IL-37 in the eutopic and ectopic endometrium of women with ovarian endometriosis and in the endometrium of patients without endometriosis...
  51. doi Interleukin-37 expression is decreased in Behçet's disease and is associated with inflammation
    Eya Bouali
    University Tunis El Manar, Faculty of Medicine of Tunis, Department of Basic Sciences, Tunis, Tunisia Unit Research 12SP15 Homeostasis and Cell Dysfunction, Abderrahman Mami Hospital, University Tunis El Manar, Tunisia
    Immunol Lett 167:87-94. 2015
    ....
  52. doi IL-37 Expression is Upregulated in Patients with Tuberculosis and Induces Macrophages Towards an M2-like Phenotype
    Z Huang
    Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China
    Scand J Immunol 82:370-9. 2015
    ..Thus, IL-37 may be a novel research target to understand the pathogenesis of TB infection...
  53. pmc Interleukin-37 Expression Is Increased in Chronic HIV-1-Infected Individuals and Is Associated with Inflammation and the Size of the Total Viral Reservoir
    Jesper F Højen
    Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark
    Mol Med 21:337-45. 2015
    ..A relationship with the activation of the monocyte compartment is suggested by the correlation with sCD14 and, interestingly, IL-37 could be related to the size of the total viral HIV-1 reservoir. ..
  54. ncbi [Clinical detection and significance of plasma IL-37 in patients with active pulmonary tuberculosis]
    Junai Zhang
    Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan 523808 Department of Clinical Immunology, Institute of Laboratory Medicine, Guangdong Medical College, Dongguan 523808, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 31:520-3. 2015
    To investigate the level of plasma interleukin 37 (IL-37) and explore the clinical significance of IL-37 in patients with active pulmonary tuberculosis (ATB).
  55. ncbi IL-37 (IL-1F7) the newest anti-inflammatory cytokine which suppresses immune responses and inflammation
    S Tete
    Dental School, University of Chieti Pescara, Italy
    Int J Immunopathol Pharmacol 25:31-8. 2012
    ....
  56. doi Associations of the IL-1F7 gene polymorphisms with rheumatoid arthritis in Chinese Han population
    B Pei
    Department of Rheumatology and Immunology, The First Affiliated Hospital, Anhui Medical University, Hefei, China
    Int J Immunogenet 40:199-203. 2013
    ..Patients carrying A allele had less severe disease activity than those not carrying this allele, suggesting that the A allele of IL-1F7 gene (rs3811047) may have a protective effect on RA...
  57. doi Analysis of nuclear localization of interleukin-1 family cytokines by flow cytometry
    Ralf Ross
    Immunology, FB 08, Justus Liebig University, Giessen, Germany
    J Immunol Methods 387:219-27. 2013
    ..In summary, we present a robust method to analyze and quantitate nuclear localization of IL-1 cytokine family members...
  58. doi Excited-state proton transfer of fluorescein anion as an ionic liquid component
    Catarina A B Rodrigues
    Research Institute for Medicines and Pharmaceutical Sciences iMED UL, Faculty of Pharmacy, University of Lisbon, Av Prof Gama Pinto, 1649 003 Lisbon, Portugal
    J Phys Chem B 117:14108-14. 2013
    ..The 1:1 molar ratio ionic liquid (FIL1) is essentially composed of monoanionic fluorescein, while dianionic fluorecein is predominant in the FIL with a 1:..
  59. ncbi Molecular characterization of a multi-promoter gene encoding a chicken filamin protein
    C P Barry
    Biotechnology Center, Ohio State University, Columbus 43210
    J Biol Chem 268:25577-86. 1993
    ..Filamin is encoded within a multi-promoter transcription unit. A downstream filamin promoter (Fil1) resembles those of certain housekeeping genes and has a putative binding site for the transcription factor E2F...
  60. ncbi Molecular cloning of the interleukin-1 gene cluster: construction of an integrated YAC/PAC contig and a partial transcriptional map in the region of chromosome 2q13
    H G Nothwang
    University Children s Hospital, Freiburg University, Germany
    Genomics 41:370-8. 1997
    ..FISH analysis localized PAC clones containing the IL-1 gene cluster to 2q12-q13. The data provide the basis for further characterization of the IL-1 gene cluster and for the construction of a sequence-ready PAC contig of this region...
  61. ncbi A regulatory factor, Fil1p, involved in derepression of the isocitrate lyase gene in Saccharomyces cerevisiae--a possible mitochondrial protein necessary for protein synthesis in mitochondria
    T Kanai
    Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Japan
    Eur J Biochem 256:212-20. 1998
    ..of Candida tropicalis isocitrate lyase gene (UPR-ICL)-mediated gene expression in acetate medium, and the gene (FIL1) that complemented this mutation was isolated...
  62. ncbi Deletion of SFI1, a novel suppressor of partial Ras-cAMP pathway deficiency in the yeast Saccharomyces cerevisiae, causes G(2) arrest
    P Ma
    Laboratorium voor Moleculaire Celbiologie, Katholieke Universiteit Leuven, Leuven, Belgium
    Yeast 15:1097-109. 1999
    ..Transformation of the fil1 mutant, which harbours a point mutation in adenylate cyclase, with a yeast gene library on a single copy plasmid ..
  63. ncbi Characterization of a new set of mutants deficient in fermentation-induced loss of stress resistance for use in frozen dough applications
    P Van Dijck
    Laboratorium voor Moleculaire Celbiologie, Katholieke Universiteit Leuven, Flanders, Belgium
    Int J Food Microbiol 55:187-92. 2000
    ..The fil1 mutant had a partially inactivating point mutation in CYR1, the gene encoding adenylate cyclase, while fil2 ..
  64. pmc Temperature-sensitive mutation in yeast mitochondrial ribosome recycling factor (RRF)
    Emeline Teyssier
    Department of Biochemistry and Molecular Pharmacology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107 5541, USA
    Nucleic Acids Res 31:4218-26. 2003
    The yeast protein Rrf1p encoded by the FIL1 nuclear gene bears significant sequence similarity to Escherichia coli ribosome recycling factor (RRF). Here, we call FIL1 Ribosome Recycling Factor of yeast, RRF1...
  65. ncbi The high general stress resistance of the Saccharomyces cerevisiae fil1 adenylate cyclase mutant (Cyr1Lys1682) is only partially dependent on trehalose, Hsp104 and overexpression of Msn2/4-regulated genes
    Matthias Versele
    Department of Molecular Microbiology, Flemish Interuniversity Institute for Biotechnology VIB, Katholieke Universiteit Leuven, Kasteelpark Arenberg 31, B 3001 Leuven Heverlee, Flanders, Belgium
    Yeast 21:75-86. 2004
    ..Previously we identified a mutant which is deficient in fermentation-induced loss of stress resistance (fil1), as a partially inactivating mutant in adenylate cyclase...
  66. ncbi Association between the interleukin-1 family gene cluster and psoriatic arthritis
    Proton Rahman
    Memorial University of Newfoundland, St Clare s Mercy Hospital, St John s, Newfoundland, Canada
    Arthritis Rheum 54:2321-5. 2006
    ....
  67. ncbi Cultured human periodontal ligament cells constitutively express multiple osteotropic cytokines and growth factors, several of which are responsive to mechanical deformation
    Mark N Pinkerton
    Department of Oral Sciences, Faculty of Dentistry, University of Otago, PO Box 647, Dunedin, New Zealand
    J Periodontal Res 43:343-51. 2008
    ..Our objective was to expand our knowledge of the cytokines and growth factors expressed by human periodontal ligament (PDL) cells and to identify new genes that are responsive to mechanical deformation...
  68. doi IL-1F5 mediates anti-inflammatory activity in the brain through induction of IL-4 following interaction with SIGIRR/TIR8
    Ceire Costelloe
    Trinity College Institute for Neuroscience, Trinity College, Dublin, Ireland
    J Neurochem 105:1960-9. 2008
    ..In contrast to its effects in brain tissue, IL-1F5 did not attenuate LPS-induced changes, or up-regulated IL-4 in macrophages or dendritic cells, suggesting that the effect is confined to the brain...
  69. ncbi Interleukin 1 polymorphisms in patients with ankylosing spondylitis in Korea
    Tae Jong Kim
    Chonnam National University Medical School and Hospital, Gwangju, Seoul, Korea
    J Rheumatol 35:1603-8. 2008
    ..We examined the association between the IL-1 gene cluster and susceptibility to AS in Korea...
  70. pmc Differential expression of immunoregulatory genes in monocytes in response to Porphyromonas gingivalis and Escherichia coli lipopolysaccharide
    H E Barksby
    Periodontal Immunobiology Research Group, School of Dental Sciences, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Clin Exp Immunol 156:479-87. 2009
    ..We conclude that differences in signalling pathways activated by TLR-2 and TLR-4 ligands lead to differential innate immune responses which may be important in polymicrobial diseases such as periodontal disease...
  71. pmc Stilbene synthase gene transfer caused alterations in the phenylpropanoid metabolism of transgenic strawberry (Fragaria x ananassa)
    Kati Hanhineva
    Department of Biosciences, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
    J Exp Bot 60:2093-106. 2009
    ..frost grape (Vitis riparia) under the control of the cauliflower mosaic virus 35S and the floral filament-specific fil1 promoters...
  72. doi The interleukin-1 family gene polymorphisms in Korean patients with rheumatoid arthritis
    M Y Jung
    Kohwang Medical Research Institute, Seoul, Korea
    Scand J Rheumatol 39:190-6. 2010
    ..The interleukin (IL)-1 family and its related family members are primary inflammatory cytokines. The aim of this study was to assess the possible association between nine IL-1 family gene polymorphisms and rheumatoid arthritis (RA)...
  73. pmc Regulation and function of the IL-1 family cytokine IL-1F9 in human bronchial epithelial cells
    Regina T Chustz
    Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, 240 E Huron, Chicago, IL 60611, USA
    Am J Respir Cell Mol Biol 45:145-53. 2011
    ..g., by respiratory viral infection) and exposure to cytokines from Th17 cells (IL-17) and inflammatory cells (TNF) may amplify neutrophilic inflammation in the airway via induction of IL-1F9 and activation of fibroblasts...
  74. doi Stress tolerance of the Saccharomyces cerevisiae adenylate cyclase fil1 (CYR1) mutant depends on Hsp26
    Cristina R Vianna
    Departamento de Microbiologia, ICB, Universidade Federal de Minas Gerais, CDTN, CNEM, Belo Horizonte, Brazil
    J Mol Microbiol Biotechnol 19:140-6. 2010
    ..Different mutants (e.g. fil1, an adenylate cyclase mutant CYR1(lys1682)) that are affected in this loss of stress resistance have been isolated, ..
  75. doi Analysis on the interaction between IL-1F7 gene and environmental factors on patients with ankylosing spondylitis: a case-only study
    Rui Ge
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China
    Mol Biol Rep 38:2281-4. 2011
    ..Thus, drinking may be a risk exposure factor to take combined action with predisposing genes in AS patients. This action may increase the incident risk of AS. Also, main plants fats may be protective factors to AS...
  76. doi Expression of interleukin (IL)-1 family members upon stimulation with IL-17 differs in keratinocytes derived from patients with psoriasis and healthy donors
    P Muhr
    Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany
    Br J Dermatol 165:189-93. 2011
    ..Interleukin (IL)-17 is an important inflammatory mediator in skin psoriasis...
  77. doi IL-37: a new anti-inflammatory cytokine of the IL-1 family
    Diana Boraschi
    Laboratory of Innate Immunity and Cytokines, Institute of Biomedical Technologies, National Research Council, I 56124 Pisa, Italy
    Eur Cytokine Netw 22:127-47. 2011
    ..The finding that IL-37 also locates to the nucleus, as do IL-1α and IL-33, for receptor-independent organ/tissue-specific regulation of inflammation is also reviewed...

Research Grants1

  1. CHARLES ANTHONY DINARELLO; Fiscal Year: 2014
    ..The project seeks to understand how inflammation caused by cytokines is controlled. This information will result in a better understanding of disease severity and possibly new anti-inflammatory therapies. ..