Genomes and Genes
Gene Symbol: IL36G
Description: interleukin 36, gamma
Alias: IL-1F9, IL-1H1, IL-1RP2, IL1E, IL1F9, IL1H1, IL1RP2, interleukin-36 gamma, IL-1 related protein 2, IL-1(EPSILON), IL-1-epsilon, interleukin 1-related protein 2, interleukin-1 epsilon, interleukin-1 family member 9, interleukin-1 homolog 1
- IRF6 Regulates the Expression of IL-36γ by Human Oral Epithelial Cells in Response to Porphyromonas gingivalisJennifer Huynh
Oral Health Cooperative Research Centre, Melbourne Dental School, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, Victoria 3010, Australia and
J Immunol 196:2230-8. 2016..Thus, our findings suggest that IRF6 is likely to promote inflammation to P. gingivalis through its regulation of IL-36γ. ..
- IL-36 promotes myeloid cell infiltration, activation, and inflammatory activity in skinAlexander M Foster
Department of Dermatology, University of Michigan, Ann Arbor, MI 48109 and
J Immunol 192:6053-61. 2014..These data indicate that IL-36 cytokines actively propagate skin inflammation via the activation of keratinocytes, APC, and, indirectly, T cells. ..
- Genetic predisposition to calcific aortic stenosis and mitral annular calcificationAnton G Kutikhin
Research Institute for Complex Issues of Cardiovascular Diseases under the Siberian Branch of the Russian Academy of Medical Sciences, Sosnovy Blvd 6, 650002, Kemerovo, Russian Federation
Mol Biol Rep 41:5645-63. 2014..the AGTR1 gene, rs2071307 polymorphism within the ELN gene, rs17659543 and rs13415097 polymorphisms within the IL1F9 gene may correlate with a risk of calcific valve stenosis with moderate level of evidence...
- IL-1F5, -F6, -F8, and -F9: a novel IL-1 family signaling system that is active in psoriasis and promotes keratinocyte antimicrobial peptide expressionAndrew Johnston
Department of Dermatology, University of Michigan, Ann Arbor, MI 48109, USA
J Immunol 186:2613-22. 2011..Collectively, our data suggest important roles for these novel cytokines in inflammatory skin diseases and identify these peptides as potential targets for antipsoriatic therapies...
- Regulation and function of the IL-1 family cytokine IL-1F9 in human bronchial epithelial cellsRegina T Chustz
Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, 240 E Huron, Chicago, IL 60611, USA
Am J Respir Cell Mol Biol 45:145-53. 2011..g., by respiratory viral infection) and exposure to cytokines from Th17 cells (IL-17) and inflammatory cells (TNF) may amplify neutrophilic inflammation in the airway via induction of IL-1F9 and activation of fibroblasts...
- Decreased Langerhans cell responses to IL-36γ: altered innate immunity in patients with recurrent respiratory papillomatosisJames DeVoti
Feinstein Institute for Medical Research, Manhasset, New York, United States of America Division of Allergy and Immunology, Department of Pediatrics, Hofstra North Shore LIJ School of Medicine, Great Neck, New York, United States of America
Mol Med 20:372-80. 2014....
- A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genesM J Nicklin
Department of Medicine and Pharmacology, University of Sheffield, Royal Hallamshire Hospital, United Kingdom
Genomics 19:382-4. 1994..Relative to one terminal CpG island, the three genes were mapped to the following intervals: IL1A was between +0 and +35 kb, IL1B was between +70 and +110 kb, and IL1RN was between +330 and +430 kb...
- Alarmin function of cathelicidin antimicrobial peptide LL37 through IL-36γ induction in human epidermal keratinocytesNa Li
Department of Dermatology, Graduate School of Medicine, Tohoku University, Sendai, Miyagi 980 8574, Japan and
J Immunol 193:5140-8. 2014..Among LL37-inducible genes, IL-1 cluster genes, particularly IL36G, are of interest because we observed coordinate increases in CAMP and IL-36γ in the lesional skin of psoriasis, ..
- IL-36γ (IL-1F9) is a biomarker for psoriasis skin lesionsAngelo Massimiliano D'Erme
1 Department of Dermatology, University of Bonn, Bonn, Germany 2 Division of Dermatology, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy
J Invest Dermatol 135:1025-32. 2015..Furthermore, IL-36γ might also provide a future drug target, because of its potential amplifier role in TNFα- and IL-17 pathways in psoriatic skin inflammation. ..
- Transcriptional landscape of psoriasis identifies the involvement of IL36 and IL36RNMaris Keermann
Department of Dermatology, University of Tartu, Tartu, Estonia
BMC Genomics 16:322. 2015..We sequenced total RNA from 12 lesional (LP), 12 non-lesional (NLP) and from 12 normal (C) skin biopsies...
- IL-36γ Transforms the Tumor Microenvironment and Promotes Type 1 Lymphocyte-Mediated Antitumor Immune ResponsesXuefeng Wang
Department of Immunology, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15261, USA Department of Biochemistry and Molecular Biology, School of Biology and Basic Medical Sciences, Soochow University, Suzhou 215123, China Department of Immunology, Institute of Medical Biotechnology, School of Biology and Basic Medical Sciences, Soochow University, Suzhou 215123, China
Cancer Cell 28:296-306. 2015..Our study establishes a role of IL-36γ in promoting antitumor immune responses and suggests its potential clinical translation into cancer immunotherapy. ..
- Synergistic Proinflammatory Responses by IL-17A and Toll-Like Receptor 3 in Human Airway Epithelial CellsKazutaka Mori
Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama Higashi ku, Hamamatsu 431 3192, Japan
PLoS ONE 10:e0139491. 2015....
- Elevated Expression and Pro-Inflammatory Activity of IL-36 in Patients with Systemic Lupus ErythematosusMan Chu
Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong, China
Molecules 20:19588-604. 2015..05). This cross-sectional study demonstrated that over expression of circulating IL-36α may exert a proinflammatory effect as observed in human SLE. ..
- Interleukin-1 polymorphisms are associated with the inflammatory response in human muscle to acute resistance exerciseRichard A Dennis
Department of Geriatrics, University of Arkansas for Medical Sciences, 4301 West Markham, Little Rock, AR 72205, USA
J Physiol 560:617-26. 2004..This is the first report that IL-1 genotype is associated with the inflammation of skeletal muscle following acute resistance exercise that may potentially affect the adaptations to chronic resistance exercise...
- Interleukin (IL)-1β Is a Strong Inducer of IL-36γ Expression in Human Colonic MyofibroblastsKenichiro Takahashi
Department of Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
PLoS ONE 10:e0138423. 2015..Interleukin (IL)-36 cytokines are members of the IL-1 cytokine family. In this study, we investigated the expression of IL-36γ in human colonic myofibroblasts to explore the molecular mechanisms underlying IL-36γ induction...
- Brazilian Red Propolis Attenuates Inflammatory Signaling Cascade in LPS-Activated MacrophagesBruno Bueno-Silva
Department of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil
PLoS ONE 10:e0144954. 2015..transcription of genes in inflammatory signaling (Pdk1, Pak1, Nfkb1, Mtcp1, Gsk3b, Fos and Elk1) and of Il1β and Il1f9 (fold-change rate > 5), which were further confirmed by the inhibition of NF-κB and MAPK signaling pathways...
- Genomic organization of the interleukin-1 locusScott L Taylor
Immunex Corporation, 51 University Street, Seattle, Washington 98101, USA
Genomics 79:726-33. 2002..There is a break in the mouse locus of > 100 kb, compared with the human locus, located between Il1b and the most centromere-proximal of the novel mouse genes. The mouse seems to be missing an ortholog of human IL1F7...
- A sequence-based map of the nine genes of the human interleukin-1 clusterMartin J H Nicklin
Division of Genomic Medicine, University of Sheffield, Royal Hallamshire Hospital, Sheffield S10 2JF, UK
Genomics 79:718-25. 2002..Gene order from centromere to telomere is IL1A-IL1B-IL1F7-IL1F9-IL1F6-IL1F8-IL1F5-IL1F10-IL1RN, of which only IL1A, IL1B, and IL1F8 are transcribed towards the centromere...
- A new nomenclature for IL-1-family genesJ E Sims
Trends Immunol 22:536-7. 2001
- Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2R Debets
DNAX Research Institute of Molecular and Cellular Biology, 901 California Avenue, Palo Alto, CA 94304, USA
J Immunol 167:1440-6. 2001....
- Cloning and characterization of IL-1HY2, a novel interleukin-1 family memberH Lin
Functional Genomics Department, Hyseq Inc, Sunnyvale, California 94086, USA
J Biol Chem 276:20597-602. 2001..These data suggest that IL-1HY2 is a novel IL-1 family member and that it may participate in a network of IL-1 family members to regulate adapted and innate immune responses...
- IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1RrpG Pan
Department of Endocrinology, Genentech, Inc, 1 DNA Way, South San Francisco, CA, 94080, USA
Cytokine 13:1-7. 2001..These findings suggest that IL-1H may be another ligand for the IL-18 receptor and a new player in the inflammatory and immune responses mediated by the IL-18/IL-18R axis...
- A tissue specific IL-1 receptor antagonist homolog from the IL-1 cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activitiesJ L Barton
Division of Molecular and Genetic Medicine, University of Sheffield, Sheffield, GB
Eur J Immunol 30:3299-308. 2000..We conclude, contrary to a recent suggestion made by others, that IL-1L1 is not a functional IL-1ra. IL-1L1 also had no detectable agonistic or antagonistic effect on IFN-gamma production in response to IL-18 in KG-1 cells...
- Identification and gene organization of three novel members of the IL-1 family on human chromosome 2S J Busfield
Millennium Pharmaceuticals Inc, 640 Memorial Drive, Cambridge, Massachusetts, 02139, USA
Genomics 66:213-6. 2000..These genes may prove to have an important role in inflammatory responses...
- Identification and initial characterization of four novel members of the interleukin-1 familyS Kumar
Department of Bone and Cartilage Biology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
J Biol Chem 275:10308-14. 2000..This suggests that IL-1H1 may be involved in pathogenesis of immune mediated disease processes. The addition of four novel IL-1 homologues suggests that the IL-1 family is significantly larger than previously thought...
- Four new members expand the interleukin-1 superfamilyD E Smith
Immunex Corp, Seattle, Washington 98101, USA
J Biol Chem 275:1169-75. 2000..Protein structure modeling also suggests that the FIL1 genes are related to IL-1beta and IL-1ra. The novel genes form a cluster with the IL-1s on the long arm of human chromosome 2...
- IL1HY1: A novel interleukin-1 receptor antagonist geneJ J Mulero
Functional Genomics Department, Immunology Group, Hyseq Inc, 670 Almanor Avenue, Sunnyvale, California 94086, USA
Biochem Biophys Res Commun 263:702-6. 1999..Furthermore, the message can be induced in THP-1 cells by phorbol ester (PMA) and lipopolysaccharide (LPS) treatment...
- IL-36γ/IL-1F9, an innate T-bet target in myeloid cellsMalte Bachmann
Pharmazentrum frankfurt ZAFES, University Hospital, Goethe University Frankfurt, 60590 Frankfurt am Main, Germany
J Biol Chem 287:41684-96. 2012..Data presented herein shed further light on involvement of T-bet in innate immunity and suggest that IL-36γ, besides IFNγ, may contribute to functions of this transcription factor in immunopathology...
- The double-stranded RNA analogue polyinosinic-polycytidylic acid induces keratinocyte pyroptosis and release of IL-36γLi Hua Lian
Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
J Invest Dermatol 132:1346-53. 2012..Interestingly, transcription of the gene IL36G was dependent on caspase-1, but not caspase-3/7, activation...
- Expression of IL-1Rrp2 by human myelomonocytic cells is unique to DCs and facilitates DC maturation by IL-1F8 and IL-1F9Shilla Mutamba
School of Veterinary Medicine and Science, University of Nottingham, UK
Eur J Immunol 42:607-17. 2012....
- Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammationAndrew Johnston
Department of Dermatology, University of Michigan, Ann Arbor, MI 48109, USA
J Immunol 190:2252-62. 2013..These findings identify a role for IL-17C in skin inflammation and suggest a pathogenic function for the elevated IL-17C observed in lesional psoriasis skin...
- IL-1Rrp2 expression and IL-1F9 (IL-1H1) actions in brain cellsElisabet Berglöf
School of Biological Sciences, University of Manchester, 1 124 Stopford Building, Oxford Road, M13 9PT, Manchester, UK
J Neuroimmunol 139:36-43. 2003..However, IL-1F9 failed to induce any of the classical IL-1beta responses, suggesting that it may trigger alternative pathway(s)...
- Interleukin-1 family member 9 stimulates chemokine production and neutrophil influx in mouse lungsRavisankar A Ramadas
Department of Pediatrics, University of Florida, Gainesville, USA
Am J Respir Cell Mol Biol 44:134-45. 2011..These data suggest that IL-1F9 is upregulated during inflammation, and acts as a proinflammatory cytokine in the lungs...
- Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36α, IL-36β, and IL-36γ) or antagonist (IL-36Ra) activityJennifer E Towne
Department of Inflammation Research, Amgen Incorporated, Seattle, Washington 98119, USA
J Biol Chem 286:42594-602. 2011..In addition, truncation of IL-36α, IL-36β, and IL-36γ dramatically enhances their activity, suggesting that post-translational processing is required for full activity...
- IL-36R ligands are potent regulators of dendritic and T cellsSolenne Vigne
Division of Rheumatology and Department of Pathology Immunology, University of Geneva School of Medicine, Geneva, Switzerland
Blood 118:5813-23. 2011..Our data thus indicate a critical role of IL-36R ligands in the interface between innate and adaptive immunity, leading to the stimulation of T helper responses...
- Expression of interleukin (IL)-1 family members upon stimulation with IL-17 differs in keratinocytes derived from patients with psoriasis and healthy donorsP Muhr
Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany
Br J Dermatol 165:189-93. 2011..Interleukin (IL)-17 is an important inflammatory mediator in skin psoriasis...
- Gene expression profile of human lymphocytes exposed to (211)At alpha particlesA Turtoi
Forschungszentrum Julich, Department of Safety and Radiation Protection, Germany
Radiat Res 174:125-36. 2010..Eight selected early-response genes that displayed a sustained up- or down-regulation (CD36, HSPA2, MS4A6A, NFIL3, IL1F9, IRX5, RASL11B and SULT1B1) were further validated in alpha-particle-irradiated lymphocytes of two human ..
- The interleukin-1 family gene polymorphisms in Korean patients with rheumatoid arthritisM Y Jung
Kohwang Medical Research Institute, Seoul, Korea
Scand J Rheumatol 39:190-6. 2010..The interleukin (IL)-1 family and its related family members are primary inflammatory cytokines. The aim of this study was to assess the possible association between nine IL-1 family gene polymorphisms and rheumatoid arthritis (RA)...
- Rhinovirus-induced modulation of gene expression in bronchial epithelial cells from subjects with asthmaY A Bochkov
Department of Pediatrics, University of Wisconsin, Madison, Wisconsin, USA
Mucosal Immunol 3:69-80. 2010..and cluster analysis showed some up- and downregulated genes in asthma cells involved in immune responses (IL1B, IL1F9, IL24, and IFI44) and airway remodeling (LOXL2, MMP10, FN1)...
- Interleukin 1 polymorphisms in patients with ankylosing spondylitis in KoreaTae Jong Kim
Chonnam National University Medical School and Hospital, Gwangju, Seoul, Korea
J Rheumatol 35:1603-8. 2008..We examined the association between the IL-1 gene cluster and susceptibility to AS in Korea...
- IL-1F5 mediates anti-inflammatory activity in the brain through induction of IL-4 following interaction with SIGIRR/TIR8Ceire Costelloe
Trinity College Institute for Neuroscience, Trinity College, Dublin, Ireland
J Neurochem 105:1960-9. 2008..In contrast to its effects in brain tissue, IL-1F5 did not attenuate LPS-induced changes, or up-regulated IL-4 in macrophages or dendritic cells, suggesting that the effect is confined to the brain...
- The expanding family of interleukin-1 cytokines and their role in destructive inflammatory disordersH E Barksby
Oral Microbiology and Host Responses Group, Oral Biology, School of Dental Sciences, Newcastle University, UK
Clin Exp Immunol 149:217-25. 2007..g. anti-IL-18 antibodies). This review highlights the emerging data on these novel IL-1 cytokines and assesses their possible role in the pathogenesis and therapy of destructive inflammatory disorders such as RA and periodontitis...
- IL-1 Receptor antagonist as a positional candidate gene in a murine model of allergic asthmaRavisankar A Ramadas
Comparative Medicine and Integrative Biology Program, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
Immunogenetics 58:851-5. 2006..We examined other IL-1 family members (Il1a, Il1b, Il1f9, and Il1r2) and found OVA-induced expression increases at 6 h, yet only Il1b and Il1f9 had strain-specific ..
- Transcriptional response of bronchial epithelial cells to Pseudomonas aeruginosa: identification of early mediators of host defenseJoost B Vos
Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
Physiol Genomics 21:324-36. 2005..aeruginosa is characterized by expression of genes involved in epithelial barrier formation and host defense...
- Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKsJennifer E Towne
Amgen Corporation, Seattle, Washington 98101, USA
J Biol Chem 279:13677-88. 2004..We conclude that IL-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP...
- Interleukin-1F7B (IL-1H4/IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma productionSanjay Kumar
Musculoskeletal Diseases, GlaxoSmithKline, 709 Swedeland Road, King of Prussia, PA, 19406, USA
Cytokine 18:61-71. 2002..Finally, we have localized the expression of IL-1F7b protein in discrete cell populations including plasma cells and tumor cells. These data suggest that IL-1F7b may be involved in immune response, inflammatory diseases and/or cancer...
- Molecular cloning of the interleukin-1 gene cluster: construction of an integrated YAC/PAC contig and a partial transcriptional map in the region of chromosome 2q13H G Nothwang
University Children s Hospital, Freiburg University, Germany
Genomics 41:370-8. 1997..FISH analysis localized PAC clones containing the IL-1 gene cluster to 2q12-q13. The data provide the basis for further characterization of the IL-1 gene cluster and for the construction of a sequence-ready PAC contig of this region...
- The role of novel IL-1 like cytokines in asthmaRavisankar A Ramadas; Fiscal Year: 2012..Results from this study will provide critical insights into the functional relevance and therapeutic potential of these cytokines in asthma. ..