IL32

Summary

Gene Symbol: IL32
Description: interleukin 32
Alias: IL-32alpha, IL-32beta, IL-32delta, IL-32gamma, NK4, TAIF, TAIFa, TAIFb, TAIFc, TAIFd, interleukin-32, interleukin-32 eta, interleukin-32 small, interleukin-32 theta, natural killer cell transcript 4, natural killer cells protein 4, tumor necrosis factor alpha-inducing factor
Species: human

Top Publications

  1. ncbi Interleukin-32: a cytokine and inducer of TNFalpha
    Soo Hyun Kim
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Immunity 22:131-42. 2005
  2. pmc Proteinase 3 is an IL-32 binding protein
    Daniela Novick
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel
    Proc Natl Acad Sci U S A 103:3316-21. 2006
  3. pmc Mycobacterium tuberculosis induces interleukin-32 production through a caspase- 1/IL-18/interferon-gamma-dependent mechanism
    Mihai G Netea
    Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado, USA
    PLoS Med 3:e277. 2006
  4. ncbi Rheumatoid arthritis and interleukin-32
    H Shoda
    Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    Cell Mol Life Sci 64:2671-9. 2007
  5. doi Unique expression of a small IL-32 protein in the Jurkat leukemic T cell line
    Na Young Ko
    Department of Immunology, College of Medicine, Konkuk University, Chungju 380 701, Republic of Korea
    Cytokine 42:121-7. 2008
  6. pmc Interleukin-32 induces the differentiation of monocytes into macrophage-like cells
    Mihai G Netea
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 105:3515-20. 2008
  7. pmc Activation of interleukin-32 pro-inflammatory pathway in response to influenza A virus infection
    Wei Li
    State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, People s Republic of China
    PLoS ONE 3:e1985. 2008
  8. ncbi Proteinase 3-processed form of the recombinant IL-32 separate domain
    Sunjong Kim
    Department of Respiratory Medicine, Konkuk University, Korea
    BMB Rep 41:814-9. 2008
  9. pmc IL-32-dependent effects of IL-1beta on endothelial cell functions
    Claudia A Nold-Petry
    Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 106:3883-8. 2009
  10. doi Tumor necrosis factor alpha-induced interleukin-32 is positively regulated via the Syk/protein kinase Cdelta/JNK pathway in rheumatoid synovial fibroblasts
    Se Hwan Mun
    Konkuk University, Chungju, Korea
    Arthritis Rheum 60:678-85. 2009

Research Grants

Detail Information

Publications160 found, 100 shown here

  1. ncbi Interleukin-32: a cytokine and inducer of TNFalpha
    Soo Hyun Kim
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Immunity 22:131-42. 2005
    ....
  2. pmc Proteinase 3 is an IL-32 binding protein
    Daniela Novick
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel
    Proc Natl Acad Sci U S A 103:3316-21. 2006
    ..Therefore, specific inhibition of PR3 activity to process IL-32 or neutralization of IL-32 by inactive PR3 or its fragments may reduce the consequences of IL-32 in immune regulated diseases...
  3. pmc Mycobacterium tuberculosis induces interleukin-32 production through a caspase- 1/IL-18/interferon-gamma-dependent mechanism
    Mihai G Netea
    Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado, USA
    PLoS Med 3:e277. 2006
    ..Interleukin (IL)-32 is a newly described proinflammatory cytokine that seems likely to play a role in inflammation and host defense. Little is known about the regulation of IL-32 production by primary cells of the immune system...
  4. ncbi Rheumatoid arthritis and interleukin-32
    H Shoda
    Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    Cell Mol Life Sci 64:2671-9. 2007
    ..Interleukin-32 can thus be seen to play an important role in the pathogenesis of rheumatoid arthritis...
  5. doi Unique expression of a small IL-32 protein in the Jurkat leukemic T cell line
    Na Young Ko
    Department of Immunology, College of Medicine, Konkuk University, Chungju 380 701, Republic of Korea
    Cytokine 42:121-7. 2008
    ..Thus, the constitutive expression of IL-32 mRNA as well as the predominant production of a smaller sized IL-32 isoform in Jurkat cells may implicate a role for IL-32 in human T cell leukemia...
  6. pmc Interleukin-32 induces the differentiation of monocytes into macrophage-like cells
    Mihai G Netea
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 105:3515-20. 2008
    ..Thus, IL-32 not only contributes to host responses through the induction of proinflammatory cytokines but also directly affects specific immunity by differentiating monocytes into macrophage-like cells...
  7. pmc Activation of interleukin-32 pro-inflammatory pathway in response to influenza A virus infection
    Wei Li
    State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, People s Republic of China
    PLoS ONE 3:e1985. 2008
    ..Interleukin (IL)-32 is a recently described pro-inflammatory cytokine that has been reported to be induced by bacteria treatment in culture cells. Little is known about IL-32 production by exogenous pathogens infection in human individuals...
  8. ncbi Proteinase 3-processed form of the recombinant IL-32 separate domain
    Sunjong Kim
    Department of Respiratory Medicine, Konkuk University, Korea
    BMB Rep 41:814-9. 2008
    ..Interestingly, the N-terminal IL-32 isoform gamma separate domain evidenced the highest levels of biological activity among the IL-32 separate domains...
  9. pmc IL-32-dependent effects of IL-1beta on endothelial cell functions
    Claudia A Nold-Petry
    Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 106:3883-8. 2009
    ..This study introduces IL-32 as a critical regulator of endothelial function, expanding the properties of this cytokine relevant to coagulation, endothelial inflammation, and atherosclerosis...
  10. doi Tumor necrosis factor alpha-induced interleukin-32 is positively regulated via the Syk/protein kinase Cdelta/JNK pathway in rheumatoid synovial fibroblasts
    Se Hwan Mun
    Konkuk University, Chungju, Korea
    Arthritis Rheum 60:678-85. 2009
    ..This study was undertaken to assess IL-32 levels in RA synovial fluid (SF) and to investigate the secretion and regulation of IL-32 in RA FLS...
  11. doi Negative feedback regulation of IL-32 production by iNOS activation in response to dsRNA or influenza virus infection
    Wei Li
    The State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, PR China
    Eur J Immunol 39:1019-24. 2009
    ....
  12. pmc Molecular characterization of IL-32 in human endothelial cells
    Hanako Kobayashi
    Department of Radiation Oncology, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, 712 PRB, 2220 Pierce Ave, Nashville, TN 37232, USA
    Cytokine 46:351-8. 2009
    ..These findings improve our understanding of IL-32 in vascular endothelium. IL-32 expression might be valuable as a biomarker for cancer...
  13. pmc Interleukin-32 expression in the pancreas
    Atsushi Nishida
    Department of Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    J Biol Chem 284:17868-76. 2009
    ..Pancreatic duct cells are the local source of IL-32, and IL-32 may play an important role in inflammatory responses and pancreatic cancer growth...
  14. doi Expression of IL-32 in human lung cancer is related to the histotype and metastatic phenotype
    Carlo Sorrentino
    Department of Oncology and Neurosciences, Anatomic Pathology Section, G D Annunzio University, Italy
    Am J Respir Crit Care Med 180:769-79. 2009
    ..A strong link has been recently demonstrated between inflammation and lung cancer. Thus, we investigated whether the proinflammatory cytokine IL-32 may be involved in lung carcinogenesis and hence provide a novel therapeutic target...
  15. pmc A proinflammatory cytokine interleukin-32beta promotes the production of an anti-inflammatory cytokine interleukin-10
    Jeong Woo Kang
    Department of Bioscience and Biotechnology, Konkuk University, Seoul, Korea
    Immunology 128:e532-40. 2009
    ..Taken together, our results suggest that IL-32beta upregulates the production of an anti-inflammatory cytokine IL-10, and then IL-10 suppresses proinflammatory cytokines...
  16. doi Suppressing IL-32 in monocytes impairs the induction of the proinflammatory cytokines TNFalpha and IL-1beta
    Jaewoo Hong
    Laboratory of Cytokine Immunology, Medical Immunology Center, Institute of Biomedical Science and Technology, Konkuk University 1 Hwayang dong, Gwangjin gu, Seoul 143 701, Republic of Korea
    Cytokine 49:171-6. 2010
    ..IL-32 production leads to major proinflammatory cytokine production during the initial immune response...
  17. doi Effect of interleukin-32gamma on differentiation of osteoclasts from CD14+ monocytes
    Yong Gil Kim
    University of Ulsan, Asan Medical Center, Seoul, Korea
    Arthritis Rheum 62:515-23. 2010
    ..This study was undertaken to evaluate the effects of IL-32gamma, the most biologically active isoform, on the differentiation and activation of osteoclasts...
  18. doi IL-32 is a host protective cytokine against Mycobacterium tuberculosis in differentiated THP-1 human macrophages
    Xiyuan Bai
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Denver at Anschutz Medical Center, Denver, CO 80045, USA
    J Immunol 184:3830-40. 2010
    ..tuberculosis bacteria, which was modestly but significantly abrogated with a caspase-3 inhibitor. We conclude that IL-32 plays a host defense role against M. tuberculosis in differentiated THP-1 human macrophages...
  19. pmc Interleukin-32beta propagates vascular inflammation and exacerbates sepsis in a mouse model
    Hanako Kobayashi
    Department of Radiation Oncology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 5:e9458. 2010
    ..Inflammation is associated with most diseases, which makes understanding the mechanisms of inflammation vitally important...
  20. doi IL-32 is expressed by human primary keratinocytes and modulates keratinocyte apoptosis in atopic dermatitis
    Norbert Meyer
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland High altitude Clinic of Davos, Davos Wolfgang, Switzerland
    J Allergy Clin Immunol 125:858-865.e10. 2010
    ..IL-32 is a proinflammatory cytokine that is involved in the inflammatory processes of rheumatoid arthritis, chronic obstructive pulmonary disease, and Crohn disease. Recently, it was shown that upregulation of IL-32 induces apoptosis...
  21. pmc Innate immunity triggers IL-32 expression by fibroblast-like synoviocytes in rheumatoid arthritis
    Ghada Alsaleh
    Universite de Strasbourg, UFR Sciences Pharmaceutiques, 67401 Illkirch, France
    Arthritis Res Ther 12:R135. 2010
    ..We therefore investigated the effect of innate immune stimulation by ligands of Toll-like receptor (TLR)2, TLR3, and TLR4, and cytokines such as TNF-α and interferon (IFN)-γ, on IL-32 expression by FLSs...
  22. doi IL-32: a host proinflammatory factor against influenza viral replication is upregulated by aberrant epigenetic modifications during influenza A virus infection
    Wei Li
    State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China
    J Immunol 185:5056-65. 2010
    ..We then show that aberrant epigenetic modifications in the IL32 promoter are important in the transcriptional regulation of IL-32 expression...
  23. doi Native IL-32 is released from intestinal epithelial cells via a non-classical secretory pathway as a membrane-associated protein
    Haruki Hasegawa
    Department of Protein Science, Amgen Inc, 1201 Amgen Court West, Seattle, WA 98119, USA
    Cytokine 53:74-83. 2011
    ..Demonstration of membrane association for both intracellular and released IL-32 suggests this unique cytokine may have a complex biosynthetic pathway and mechanism of action...
  24. pmc Paradoxical effects of constitutive human IL-32{gamma} in transgenic mice during experimental colitis
    Jida Choi
    Laboratory of Cytokine Immunology, Medical Immunology Center, Department of Bioscience and Biotechnology, School of Medicine, Konkuk University, Seoul 143 701, Korea
    Proc Natl Acad Sci U S A 107:21082-6. 2010
    ..Thus IL-32γ emerges as an example of how innate inflammation worsens as well as protects intestinal integrity...
  25. doi Interleukin-32α expression in human colonic subepithelial myofibroblasts
    Yuhki Yagi
    Department of Medicine, Graduate School of Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu, Japan
    Int J Mol Med 27:263-8. 2011
    ..Human colonic SEMFs expressed IL-32α in response to IL-1ß and TNF-α. IL-32α mRNA expression depends on the phosphatidylinositol 3-kinase and the NF-κB system...
  26. pmc Activation of the interleukin-32 pro-inflammatory pathway in response to human papillomavirus infection and over-expression of interleukin-32 controls the expression of the human papillomavirus oncogene
    SoJung Lee
    Department of Bioscience and Biotechnology, Bio Molecular Informatics Centre, Seoul, Korea
    Immunology 132:410-20. 2011
    ..However, E7 and COX-2 were down-regulated in the IL-32γ over-expressing cells and recovered by IL-32 small interfering RNA, indicating that E7 and COX-2 were feedback-inhibited by IL-32γ in cervical cancer cells...
  27. pmc Overexpression of IL-32alpha increases natural killer cell-mediated killing through up-regulation of Fas and UL16-binding protein 2 (ULBP2) expression in human chronic myeloid leukemia cells
    Soyoung Cheon
    Department of Life Science, Sookmyung Women s University, and Konkuk University Hospital, Seoul 140 742, Republic of Korea
    J Biol Chem 286:12049-55. 2011
    ..Enhanced NK cell susceptibility of CML cells by IL-32α overexpression may improve the efficiency of NK cell-based immunotherapy...
  28. pmc Inflammation-dependent secretion and splicing of IL-32{gamma} in rheumatoid arthritis
    Bas Heinhuis
    Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, 6500 HB, Nijmegen, The Netherlands
    Proc Natl Acad Sci U S A 108:4962-7. 2011
    ..Splicing of IL-32γ into IL-32β is a safety switch in controlling the effects of IL-32γ and thereby reduces chronic inflammation...
  29. pmc IL-32γ inhibits cancer cell growth through inactivation of NF-κB and STAT3 signals
    J H Oh
    College of Pharmacy and Medical Research Center, Chungbuk National University, Chungbuk, Korea
    Oncogene 30:3345-59. 2011
    ..However, siRNA of NF-κB and STAT3 augmented IL-32γ-induced colon cancer cell growth inhibition. These findings indicate significant pathophysiological roles of IL-32γ in cancer development...
  30. doi Interleukin-32 expression induced by hepatitis B virus protein X is mediated through activation of NF-κB
    Xingfei Pan
    Department of Infectious Diseases, The 3rd Affiliated Hospital, Sun Yat Sen University, Guangzhou 510630, People s Republic of China
    Mol Immunol 48:1573-7. 2011
    ..In conclusion, IL-32 is induced by HBx in Huh7 cells. Our results suggest that IL-32 might play an important role in inflammatory response after HBV infection...
  31. pmc The immunosuppressive role of IL-32 in lymphatic tissue during HIV-1 infection
    Anthony J Smith
    Department of Microbiology, Medical School, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 186:6576-84. 2011
    ....
  32. doi IL-32gamma induces the maturation of dendritic cells with Th1- and Th17-polarizing ability through enhanced IL-12 and IL-6 production
    Mi Young Jung
    School of Life Sciences and Biotechnology, Korea University, Seoul 136 701, Republic of Korea
    J Immunol 186:6848-59. 2011
    ..These results demonstrated that IL-32γ could effectively induce the maturation and activation of immature DCs, leading to enhanced Th1 and Th17 responses as the result of increased IL-12 and IL-6 production in DCs...
  33. doi Inflammatory cytokines IL-32 and IL-17 have common signaling intermediates despite differential dependence on TNF-receptor 1
    Emily Turner-Brannen
    Department of Internal Medicine, Manitoba Centre for Proteomics and Systems Biology, University of Manitoba, Winnipeg, Manitoba R3E3P4, Canada
    J Immunol 186:7127-35. 2011
    ..Therefore, p300 and DAPK-1 are viable potential therapeutic targets for chronic inflammatory diseases...
  34. pmc Differential expression of interleukin-32 in chronic rhinosinusitis with and without nasal polyps
    A Keswani
    Division of Allergy Immunology, Northwestern University Feinberg School of Medicine, 240 E Huron, Chicago, IL 60611, USA
    Allergy 67:25-32. 2012
    ..However, the mechanism of inflammation in CRS has still not been fully elucidated. The aim of the study was to investigate the role of interleukin-32 (IL-32), a recently discovered proinflammatory cytokine, in CRS...
  35. doi Dysregulation of overexpressed IL-32α in hepatocellular carcinoma suppresses cell growth and induces apoptosis through inactivation of NF-κB and Bcl-2
    Yun Hee Kang
    Medical Genomics Research Center, Daejeon, Republic of Korea
    Cancer Lett 318:226-33. 2012
    ..Based on our results, we suggest that IL-32α is involved in the progression of hepatocellular carcinoma and may be a useful biomarker for diagnosis and therapeutic target of hepatocellular carcinoma...
  36. pmc Interleukin 32 (IL-32) contains a typical α-helix bundle structure that resembles focal adhesion targeting region of focal adhesion kinase-1
    Bas Heinhuis
    Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, 6500 HB, Nijmegen, The Netherlands
    J Biol Chem 287:5733-43. 2012
    ..This study demonstrates for the first time that IL-32 binds to the extracellular domain of integrins and to intracellular proteins like paxillin and FAK, suggesting a dual role for IL-32 in integrin signaling...
  37. doi Characterizing antiviral mechanism of interleukin-32 and a circulating soluble isoform in viral infection
    Suyoung Bae
    Laboratory of Cytokine Immunology, Department of Biomedical Science and Technology, Konkuk University, Seoul 143 701, Republic of Korea
    Cytokine 58:79-86. 2012
    ..The present results suggest that IL-32γ expression and its genetic variation in individual could be an important aspect of viral infections...
  38. doi Regulation and expression of IL-32 in chronic rhinosinusitis
    M B Soyka
    Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland
    Allergy 67:790-8. 2012
    ..IL-32 is a recently described cytokine, which is expressed in a variety of tissue cells and involved in the pathogenesis of several chronic inflammatory diseases...
  39. pmc Enhanced susceptibility to lipopolysaccharide-induced arthritis and endotoxin shock in interleukin-32 alpha transgenic mice through induction of tumor necrosis factor alpha
    Masanori Nakayama
    Department of Orthopaedic Surgery, Keio University, 35 Shinanomachi, Shinjuku, Tokyo 160 8582, Japan
    Arthritis Res Ther 14:R120. 2012
    ..The potential signaling pathway for the IL-32-tumor necrosis factor (TNF)α axis was analyzed in vitro...
  40. pmc Intracellular interaction of interleukin (IL)-32α with protein kinase Cε (PKCε ) and STAT3 protein augments IL-6 production in THP-1 promonocytic cells
    Jeong Woo Kang
    Department of Bioscience and Biotechnology, Bio Molecular Informatics Center, Konkuk University, 1 Hwayang dong, Gwangjin gu, Seoul 143 701, Korea
    J Biol Chem 287:35556-64. 2012
    ..Thus, our data indicate that the intracellular interaction of IL-32α with PKCε and STAT3 promotes STAT3 binding to the IL-6 promoter by enforcing STAT3 phosphorylation, which results in increased production of IL-6...
  41. doi IL-32 expression is an independent prognostic marker for gastric cancer
    Sumiya Ishigami
    Digestive Surgery Surgical Oncology, Kagoshima University School of Medicine, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Med Oncol 30:472. 2013
    ..Pro-inflammatory cytokines induce immunosuppression in a paracrine manner, thereby facilitating the metastasis of tumor cells...
  42. ncbi Clinical significance of interleukin-32 expression in patients with rheumatoid arthritis
    Ming Gui
    Department of Rheumatology and Immunology, The Third Xiangya Hospital of Central South University, Changsha, China
    Asian Pac J Allergy Immunol 31:73-8. 2013
    ....
  43. pmc Interleukin (IL)-32β-mediated CCAAT/enhancer-binding protein α (C/EBPα) phosphorylation by protein kinase Cδ (PKCδ) abrogates the inhibitory effect of C/EBPα on IL-10 production
    Jeong Woo Kang
    Department of Bioscience and Biotechnology, Bio Molecular Informatics Center, Konkuk University, 1 Hwayang dong, Gwangjin gu, Seoul 143 701, Korea
    J Biol Chem 288:23650-8. 2013
    ..Taken together, our results show that IL-32β-mediated C/EBPα Ser-21 phosphorylation by PKCδ suppressed C/EBPα binding to IL-10 promoter, which promoted IL-10 production in U937 cells. ..
  44. doi Interleukin-32β stimulates migration of MDA-MB-231 and MCF-7cells via the VEGF-STAT3 signaling pathway
    Jeong Su Park
    Research Center for Women s Disease, Sookmyung Women s University, Seoul, 140 742, South Korea
    Cell Oncol (Dordr) 36:493-503. 2013
    ..In addition to its role in these responses, IL-32 and its different isoforms have in recent years been implicated in the development of various cancers. As of yet, the role of IL-32 in breast cancer has remained largely unknown...
  45. pmc IL-32-PAR2 axis is an innate immunity sensor providing alternative signaling for LPS-TRIF axis
    Masanori Nakayama
    Department of Orthopaedic Surgery, Keio University, 35 Shinanomachi, Shinjuku, Tokyo 160 8582, Japan
    Sci Rep 3:2960. 2013
    ..IL-32-PAR2-TRIF axis might serve not only as an extracellular sensor of bacterial and autologous proteases, but also as a modulator of innate and adaptive immunity during infection. ..
  46. doi IL-32α down-regulates β2 integrin (CD18) expression by suppressing PU.1 expression in myeloid cells
    Jeong Woo Kang
    Department of Bioscience and Biotechnology, Bio Molecular Informatics Center, Konkuk University, 1 Hwayang dong, Gwangjin gu, Seoul 143 701, Republic of Korea
    Cell Signal 26:1514-22. 2014
    ..Therefore, our data suggest that IL-32α-mediated STAT3 S727 phosphorylation induced C/EBPα association, which inhibited PU.1 expression, and then resulted in the down-regulation of CD18 expression...
  47. ncbi Identification of a novel gene expressed in activated natural killer cells and T cells
    C A Dahl
    Pittsburgh Cancer Institute, University of Pittsburgh, PA 15213
    J Immunol 148:597-603. 1992
    We have isolated a cDNA clone from a human activated NK cell-derived cDNA library that identifies a transcript (NK4) that is selectively expressed in lymphocytes...
  48. ncbi Involvement of IL-32 in activation-induced cell death in T cells
    Chiho Goda
    Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, 5 1 1, Nabeshima, Saga, 849 8501, Japan
    Int Immunol 18:233-40. 2006
    NK cell transcript 4 (NK4), now denoted as IL-32, was originally identified as a transcript whose expression was increased in activated NK cells...
  49. pmc IL-32, a proinflammatory cytokine in rheumatoid arthritis
    Leo A B Joosten
    Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, The Netherlands
    Proc Natl Acad Sci U S A 103:3298-303. 2006
    ..IL-32, strongly associated with TNFalpha, IL-1beta, and IL-18, appears to play a role in human RA and may be a novel target in autoimmune diseases...
  50. ncbi Fungal control of pathogenic fungi isolated from wild plants in Taif Governorate, Saudia Arabia
    A M Abou-Zeid
    Biology Department, Faculty of Science, Taif University, Saudi Arabia P B
    Roum Arch Microbiol Immunol 66:90-6. 2007
    Twenty two plants were collected from Taif Governorate and identified as: Euphorbia glomerifera, Juniperus procera, Launaea mucronata, Capparis dcidua, Punica granatum, Opuntia ficus, Prunus persica, Eucalyptus globulus, Medicago sativa, ..
  51. pmc Suppression of human colon tumor growth by adenoviral vector-mediated NK4 expression in an athymic mouse model
    Jian Zheng Jie
    State Key Laboratory of Molecular Virology and Genetic Engineering, 9 Dong Dan San Tiao, Dong Cheng Qu, Beijing 100730, China
    World J Gastroenterol 13:1938-46. 2007
    To investigate the suppressive effects of adenoviral vector-mediated expression of NK4, an antagonist of hepatocyte growth factor (HGF), on human colon cancer in an athymic mouse model to explore the possibility of applying NK4 to cancer ..
  52. ncbi Indoor radon survey in dwellings of nine cities in the Eastern and the Western provinces of Saudi Arabia
    F Abu-Jarad
    Environmental Protection Department, Saudi Aramco, PO Box 13027, Dhahran 31311, Saudi Arabia
    Radiat Prot Dosimetry 106:227-32. 2003
    ..Abqaiq, Qatif, Al-Ahsa, Dammam and Khobar and to compare this with two cities in the Western province, Madina and Taif. So far, detailed radon data is not available for Saudi Arabia: therefore, this radon survey provides a base line ..
  53. ncbi [Effect of NK4 gene transfection on tumor growth of human pancreatic cancer xenograft in nude mice]
    Ren Xu Lai
    Department of Gastroenterology, The Fifth Affiliated Hospital, Sun Yat Sen University, Zhuhai, Guangdong, P R China
    Ai Zheng 24:1191-5. 2005
    b>NK4 is not only an antagonist of hepatocyte growth factor but also an angiogenesis inhibitor. Studies have confirmed that NK4 can inhibit tumor growth and metastasis, but its effect on pancreatic cancer remains unknown...
  54. ncbi Lamellar ichthyosis in a Saudi kindred
    Daifullah Al Aboud
    Dermatology Department, King Khalid Military City Hospital, Hafer Al Baten, Saudi Arabia
    Skinmed 6:40-1. 2007
    ..20 patients aged 4-16 years presented with lamellar ichthyosis at the dermatology unit of King Faisal Hospital at Taif in western Saudi Arabia...
  55. ncbi A study on the social structure and dispersal patterns of hamadryas baboons living in a commensal group at Taif, Saudi Arabia
    Akio Mori
    Primate Research Institute, Kyoto University, Kanrin, Inuyama, Aichi, 484 8506, Japan
    Primates 48:179-89. 2007
    ..The ease with which young males acquired adult females at the study site must have disrupted the formation of a clan, a "male-bonded society."..
  56. ncbi High rate of non-compliance with anti-tuberculosis treatment despite a retrieval system: a call for implementation of directly observed therapy in Saudi Arabia
    M S Al-Hajjaj
    King Saud University Medical College, Riyadh, Saudi Arabia
    Int J Tuberc Lung Dis 4:345-9. 2000
    b>Taif Chest Hospital, Taif, Saudi Arabia.
  57. ncbi Medical and surgical management of fecal incontinence after repair of high imperforate anus anomalies
    Talal A Al-Malki
    College of Medicine and Medical Sciences, Taif University, PO Box 888, Taif, Kingdom of Saudi Arabia
    Saudi Med J 31:284-8. 2010
    ..To report the medical and surgical management of fecal incontinence in children after repair of high imperforate anus...
  58. ncbi The human tachykinin NK1 (short form) and tachykinin NK4 receptor: a reappraisal
    Nigel M Page
    School of Animal and Microbial Sciences, The University of Reading, RG6 6AJ, Reading, UK
    Eur J Pharmacol 437:27-30. 2002
    ..of the three tachykinin receptors (NK1--both short and long forms, NK2 and NK3) and the putative human tachykinin NK4 receptor in the placenta. Human and rat placenta express all three classical tachykinin receptors...
  59. ncbi Pattern of disability among patients attending Taif Rehabilitation Center, Saudi Arabia
    Abdul Salam A Al-Shehri
    Department of Family Medicine, Al Hada Armed Forces Hospital, Saudi Arabia
    Disabil Rehabil 30:884-90. 2008
    ..Despite the growing awareness of the community about the economic, psychological and medical impact of disability, limited research has been carried out to determine the pattern of disabilities in Saudi Arabia...
  60. ncbi Attitude, awareness and practice of evidence based medicine among consultant physicians in Western region of Saudi Arabia
    Fahad K Al-Omari
    Department of Family Medicine, Al Hada Military Hospital, PO Box 7035, Al Taif, Kingdom of Saudi Arabia
    Saudi Med J 27:1887-93. 2006
    To assess the awareness, attitude and practice of evidence base medicine (EBM) among Al-Taif Consultant Physicians and to define the perceived barriers for practicing EBM.
  61. ncbi Hepatocyte growth factor up-regulates the expression of the bone morphogenetic protein (BMP) receptors, BMPR-IB and BMPR-II, in human prostate cancer cells
    Lin Ye
    Metastasis and Angiogenesis Research Group, Department of Surgery, Wales College of Medicine, Health Park, Cardiff, CF14 4XN, UK
    Int J Oncol 30:521-9. 2007
    ..Mice were treated with either HGF, the HGF antagonist NK4, or a combination of both...
  62. doi Versatility of tubularized incised plate urethroplasty in the management of different types of hypospadias: 5-year experience
    Gamal Al-Saied
    Departments of Pediatric Surgery and Urology, Al Azhar University, Cairo, Egypt King Abdul Aziz Specialist Hospital, Taif, Saudi Arabia
    Afr J Paediatr Surg 6:88-92. 2009
    ..The aim of this study was to evaluate the feasibility and applicability of TIP urethroplasty in the management of different types of hypospadias...
  63. ncbi Anti-cancer approach with NK4: Bivalent action and mechanisms
    Takahiro Nakamura
    Cancer Research Institute, Kanazawa University, Japan
    Anticancer Agents Med Chem 10:36-46. 2010
    We identified NK4, the N-terminal and four kringle domains of hepatocyte growth factor (HGF), as a specific inhibitor of HGF...
  64. ncbi Co-cultivation of pancreatic cancer cells with orthotopic tumor-derived fibroblasts: fibroblasts stimulate tumor cell invasion via HGF secretion whereas cancer cells exert a minor regulative effect on fibroblasts HGF production
    Li Wu Qian
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Cancer Lett 190:105-12. 2003
    ..A specialized HGF antagonist, NK4 would effectively inhibit the fibroblast-mediated invasive growth, thus proving the key role of the paracrine-..
  65. ncbi Mosquito fauna (Diptera: Culicidae) and seasonal activity in Makka Al Mukarramah Region, Saudi Arabia
    A M Alahmed
    College of Food and Agricultural Sciences, King Saud University, Riyadh, Saudi Arabia
    J Egypt Soc Parasitol 39:991-1013. 2009
    ..univittatus and Culiseta longiareolata. Cx. arbieeni was reported for the first time in Saudi Arabia from Al Taif District...
  66. ncbi NK4 gene therapy targeting HGF-Met and angiogenesis
    Kunio Matsumoto
    Division of Tumor Dynamics and Regulation, Kanazawa University Cancer Research Institute, 13 1 Takaramachi, Kanazawa, Japan
    Front Biosci 13:1943-51. 2008
    ..growth factor (HGF) and Met/HGF receptor tyrosine kinase play a definite role in tumor invasion and metastasis, NK4 was isolated as a competitive antagonist against functional association between HGF and Met...
  67. doi Hepatocyte growth factor and Met in tumor biology and therapeutic approach with NK4
    Kunio Matsumoto
    Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    Proteomics 8:3360-70. 2008
    ..In attempts to block the malignant behavior of cancers, NK4 was isolated as a competitive antagonist against HGF-Met signaling...
  68. ncbi Nucleic acid amplification technology for hepatitis B virus, and its role in blood donation screening in blood banks
    Mohammad S Bamaga
    Department of Molecular Pathology, Al Hada Armed Forces Hospital, Taif, Kingdom of Saudi Arabia
    Saudi Med J 30:1416-21. 2009
    ....
  69. ncbi Capripoxvirus disease in an Arabian oryx (Oryx leucoryx) from Saudi Arabia
    A Greth
    National Wildlife Research Center National Commission for Wildlife Conservation and Development, Taif, Saudi Arabia
    J Wildl Dis 28:295-300. 1992
    ..was observed in a captive-bred female Arabian oryx (Oryx leucoryx) at the National Wildlife Research Center, Taif, Saudi Arabia...
  70. pmc Functional characterization by heterologous expression of a novel cloned tachykinin peptide receptor
    L F Donaldson
    Department of Biological Chemistry, University of California at Davis Medical School 95616, USA
    Biochem J 320:1-5. 1996
    ..This 'NK4' receptor did not give functional responses in Xenopus oocytes to opioid agonists...
  71. doi Chemotherapeutic agents potentiate adenoviral gene therapy for pancreatic cancer
    Takuya Egami
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Cancer Sci 100:722-9. 2009
    ..Adenovirus (Ad-NK4) expressing NK4, which acts as a hepatocyte growth factor antagonist, was used as a representative gene therapy...
  72. doi Inhibition of Met/HGF receptor and angiogenesis by NK4 leads to suppression of tumor growth and migration in malignant pleural mesothelioma
    Yoshinori Suzuki
    Division of Molecular Regenerative Medicine, Department of Biochemistry and Molecular Biology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Int J Cancer 127:1948-57. 2010
    b>NK4 exhibits two distinct biological actions: antagonistic inhibition of hepatocyte growth factor (HGF) through binding to the Met/HGF receptor, and antiangiogenic action through binding to perlecan...
  73. ncbi Nkx-2.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants
    T J Lints
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Development 119:419-31. 1993
    ..5 and Nkx-2.6, that are new members of a sp sub-family of homeobox genes related to Drosophila NK2, NK3 and NK4/msh-2. In this paper, we focus on the Nkx-2.5 gene and its expression pattern during post-implantation development...
  74. ncbi Tumor suppression through angiogenesis inhibition by SUIT-2 pancreatic cancer cells genetically engineered to secrete NK4
    Michiyo Saimura
    Departments of Surgery and Oncology and Cancer Therapy and Research, Graduate School of Medical Sciences, Kyushu University, Maidashi, Fukuoka 812 8582, Japan
    Clin Cancer Res 8:3243-9. 2002
    b>NK4, composed of the N-terminal hairpin and subsequent four-kringle domains of hepatocyte growth factor (HGF), acts not only as a competitive antagonist of HGF but also as an inhibitor of angiogenesis...
  75. ncbi Measurements of indoor gamma radiation dose in At-Taif city, Saudi Arabia using CaSO4:Dy (TLD-900)
    Fayez H H Al-Ghorabie
    Department of Physics, Faculty of Applied Sciences, Umm Al Qura University, P O Box 10130, Makkah 21955, Saudi Arabia
    Radiat Prot Dosimetry 113:178-84. 2005
    This paper describes measurements of indoor gamma radiation dose in At-Taif city, Kingdom of Saudi Arabia. CaSO(4):Dy thermoluminescence dosemeters were used for the detection of gamma radiation in 250 houses within the city...
  76. doi Augmented anti-tumor therapy through natural targetability of macrophages genetically engineered by NK4 plasmid DNA
    T Okasora
    Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Gene Ther 15:524-30. 2008
    ..Following the reverse transfection of Mphi by the plasmid DNA of a hepatocyte growth factor antagonist (NK4) complexed with the cationized dextran, the NK4 protein was secreted at a higher amount for a longer time period in ..
  77. doi Systemic NK4 gene therapy inhibits tumor growth and metastasis of melanoma and lung carcinoma in syngeneic mouse tumor models
    Yuko Kishi
    Division of Molecular Regenerative Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Cancer Sci 100:1351-8. 2009
    Hepatocyte growth factor (HGF) promotes malignant development of cancer cells by enhancing invasion and metastasis. NK4, a competitive antagonist for HGF, is a bifunctional molecule that acts as a HGF antagonist and angiogenesis ..
  78. ncbi Nk4, a new HGF/SF variant, is an antagonist to the influence of HGF/SF on the motility and invasion of colon cancer cells
    C Parr
    University Department of Surgery, University of Wales College of Medicine, Cardiff, UK
    Int J Cancer 85:563-70. 2000
    ..We have examined here the properties of NK4, an HGF variant containing the N-terminal hairpin plus the 4 kringle domains, on tumour cell proliferation, ..
  79. pmc NK4, a four-kringle antagonist of HGF, inhibits spreading and invasion of human pancreatic cancer cells
    N Maehara
    Division of Biochemistry, Department of Oncology, Biomedical Research Center, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Br J Cancer 84:864-73. 2001
    ..properties in human pancreatic cancer cells by hepatocyte growth factor (HGF) and blockage of these properties by NK4, a newly identified antagonist for HGF...
  80. ncbi Messenger RNA localization and further characterisation of the putative tachykinin receptor NK4 (NK3B)
    L F Donaldson
    Department of Biological Chemistry, University of California at Davis, Davis, California 95616, USA
    Receptors Channels 7:259-72. 2001
    ..receptor, highly homologous to the NK3 tachykinin peptide receptor, encodes a novel functional tachykinin receptor NK4. Examining sites of receptor mRNA expression by Northern blot we show that NK4 mRNA is expressed in numerous rat ..
  81. ncbi Measurements of environmental terrestrial gamma radiation dose rate in three mountainous locations in the western region of Saudi Arabia
    Fayez H H Al-Ghorabie
    Department of Physics, Faculty of Applied Sciences, Umm Al Qura University, P O Box 10130, Makkah 21955, Saudi Arabia
    Environ Res 98:160-6. 2005
    ..These locations are At-Taif city, Al-Hada village, and Ash-Shafa village...
  82. ncbi Prevalence of airborne allergenic Amaranthus viridis pollen in seven different regions of Saudi Arabia
    Syed M Hasnain
    Department of Biological and Medical Research MBC O3 King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Ann Saudi Med 27:259-63. 2007
    ..Nevertheless, data on the prevalence of Amaranthus pollen in the environment is limited and almost non-existent for Saudi Arabia...
  83. doi Complementary striped expression patterns of NK homeobox genes during segment formation in the annelid Platynereis
    Alexandra Saudemont
    Centre de Genetique Moleculaire, CNRS UPR 2167, 1 Avenue de la Terrasse, 91198 Gif sur Yvette, France
    Dev Biol 317:430-43. 2008
    ..To test this hypothesis, we cloned and analysed the expression patterns of the homologues of NK cluster genes Msx, NK4, NK3, Lbx, Tlx, NK1 and NK5 in the marine annelid Platynereis dumerilii, a representative of trochozoans, the third ..
  84. doi Balloon inflation-created subdartos pouch during orchiopexy: a new simplified technique
    Gamal Al-Saied
    Al Azhar University, Cairo, Egypt
    Pediatr Surg Int 24:1187-90. 2008
    ....
  85. ncbi The effects of maternal brucellosis on pregnancy outcome
    Maged Elshamy
    Department of Obstetric and Gynecology, Faculty of Medicine, Mansoura University, Egypt
    J Infect Dev Ctries 2:230-4. 2008
    ..Our aim was to assess the outcome of pregnancies complicated by Brucella infection...
  86. ncbi Acute respiratory tract infections among Hajj medical mission personnel, Saudi Arabia
    Saeed Al-Asmary
    Department of Family Medicine, Al Hada Armed Forces Hospital, Taif, Saudi Arabia
    Int J Infect Dis 11:268-72. 2007
    ..of acute respiratory tract infections (ARI) among 250 personnel serving in a Hajj medical mission, Al-Hada and Taif Armed Forces Hospitals, during the 2005 season and to determine the effectiveness of protective measures, including ..
  87. doi Polyploidy impairs human aortic endothelial cell function and is prevented by nicotinamide phosphoribosyltransferase
    Nica M Borradaile
    London Health Sciences Centre, 339 Windermere Rd, London, Ontario, Canada N6A 5A5
    Am J Physiol Cell Physiol 298:C66-74. 2010
    ..decreased CCNE2/A2, RBL1, BUB1B; increased CDKN1A) and increased expression of genes involved in inflammation (IL32, TNFRSF21/10C, PTGS1) and extracellular matrix remodeling (COL5A1, FN1, MMP10/14)...
  88. ncbi Human proteinase 3 (PR3) and its binding molecules: implications for inflammatory and PR3-related autoimmune responses
    Antje Muller
    Department of Rheumatology, University of Luebeck, Germany
    Ann N Y Acad Sci 1109:84-92. 2007
    ..Altogether, there are a number of (auto)molecules that bind to PR3, some of them even competitive and each binding interaction seems to have specific implications...
  89. ncbi Quality improvement of diabetes care using flow sheets in family health practice
    Maha M Moharram
    Department of Family Medicine, Al Hada Armed Forces Hospital, Taif, Kingdom of Saudi Arabia
    Saudi Med J 29:98-101. 2008
    ..To show that the use of a flow sheet would improve performance of family physicians in diabetes care...
  90. ncbi Endogenous IL-32 controls cytokine and HIV-1 production
    Marcel F Nold
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 181:557-65. 2008
    ..In summary, depletion of endogenous IL-32 reduced the levels of Th1 and proinflammatory cytokines but paradoxically increased p24, proposing IL-32 as a natural inhibitor of HIV-1...
  91. ncbi Does the use of radiofrequency ultrasonic dissector in tonsillectomy have a beneficial effect over the use of laser?
    Mustafa T Adnan
    Department of Ear, Nose and Throat, Al Hada Armed Forces Hospital, Taif, Kingdom of Saudi Arabia
    Saudi Med J 29:1775-8. 2008
    ..To compare the intra- and post- operative morbidities on the use of radiofrequency ultrasonic dissector (US) with the use of laser during tonsillectomy in the same patients...
  92. ncbi Application of biological study for met expression to cancer therapy
    Shinji Osada
    Gifu University School of Medicine, Japan
    Anticancer Agents Med Chem 10:58-63. 2010
    ..Among these agents, NK4 and AM102 were introduced as HGF inhibitors, and PHA-665752 and Su11274 as c-Met inhibitors and are under study in ..
  93. ncbi Characteristics of mitochondrial calpains
    Taku Ozaki
    Department of Biochemistry and Biotechnology, Division of Cell Technology, Faculty of Agriculture and Life Science, Hirosaki University, Hirosaki, Japan
    J Biochem 142:365-76. 2007
    ..The mitochondrial calpain processed apoptosis-inducing factor (AIF) to truncated AIF (tAIF), releasing tAIF into the intermembrane space...
  94. doi The effects of NK4 on viral myocarditis mice
    Difei Shen
    Department of Cardiology, Renmin Hospital, Wuhan University, Wuhan, P R China
    Cardiovasc Pathol 18:323-31. 2009
    b>NK4 may be a promising agent to inhibit tumor invasion and metastasis...
  95. doi Up-regulation of integrin beta3 in radioresistant pancreatic cancer impairs adenovirus-mediated gene therapy
    Takuya Egami
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Sci 100:1902-7. 2009
    ..We used an adenovirus expressing the hepatocyte growth factor antagonist, NK4 (Ad-NK4), as a representative gene therapy...
  96. doi NK4 regulates 5-fluorouracil sensitivity in cholangiocarcinoma cells by modulating the intrinsic apoptosis pathway
    Xianxiu Ge
    Institute of Digestive Endoscopy and Medical Center for Digestive Diseases, Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210011, P R China
    Oncol Rep 30:448-54. 2013
    The aim of the present study was to investigate the role of NK4, an antagonist for hepatocyte growth factor (HGF) and the Met receptor, in regulating the response of cholangiocarcinoma (CCA) cells to 5-fluorouracil (5-FU)...
  97. pmc Effect of diaminopropionic acid (Dap) on the biophysical properties of a modified synthetic channel-forming peptide
    Urska Bukovnik
    Department of Biochemistry and Department of Anatomy and Physiology, Kansas State University, Manhattan, Kansas 66506, United States
    Mol Pharm 10:3959-66. 2013
    ..The best candidate, NK4-M2GlyR T19R, S22W (p22-T19R, S22W), was water-soluble, incorporated into cell membranes and was nonimmunogenic, but ..
  98. doi Ethanolic extract of sharah, Plectranthus aegyptiacus, enhances healing of skin wound in rats
    Mohamed Alkafafy
    Department of Biotechnology, College of Science, Taif University, Taif, Saudi Arabia Department of Cytology and Histology, College of Veterinary Medicine, University of Sadat City, Egypt
    Acta Histochem 116:627-38. 2014
    Sharah, Plectranthus aegyptiacus (Forssk.) C. Chr. is a common native plant in the Taif region of Saudi Arabia. An ethanolic extract of freeze dried sharah leaves was added as 10% (w/w) to an ointment base of beeswax and sesame oil...
  99. pmc Population dynamics and tuberculosis: a cross sectional study of an overlooked disease in Saudi Arabia
    Jamal Al-Bishri
    Dept of Medicine, College of Medicine, Taif University, Saudi Arabia
    Ger Med Sci 12:Doc02. 2014
    ..International travel, migration and human population movements facilitate the spread of tuberculosis (TB)...
  100. pmc NKP30-B7-H6 Interaction Aggravates Hepatocyte Damage through Up-Regulation of Interleukin-32 Expression in Hepatitis B Virus-Related Acute-On-Chronic Liver Failure
    Yong Zou
    Department of Blood Transfusion, The Third Affiliated Hospital of Sun Yat Sen University, Guangzhou, China
    PLoS ONE 10:e0134568. 2015
    ..However, the underlying mechanisms remain to be elucidated. In the present study, we aimed to discover the role of NKP30-B7-H6 interaction in NK cells-mediated hepatocyte damage in HBV-ACLF...
  101. doi Overexpression of truncated AIF regulated by Egr1 promoter radiation-induced apoptosis on MCF-7 cells
    Jianfeng Wang
    Department of Radiotherapy, China Japan Union Hospital, Jilin University, Changchun, Jilin Province, People s Republic of China
    Radiat Environ Biophys 54:413-21. 2015
    ..In the present study, we overexpressed truncated AIF on MCF-7 cells by transfection of pcDNA3.1-tAIF (pc-tAIF) and pcDNA3.1-Egr1-tAIF (pc-Egr1-tAIF) plasmids...

Research Grants1

  1. Examination of FLT3 Mutations in Acute Myeloid Leukemia
    Derek Stirewalt; Fiscal Year: 2006
    ..Together, the research proposal and educational program provide Dc Stirewalt with the skills to become an independent clinical investigator. ..