IL1R1

Summary

Gene Symbol: IL1R1
Description: interleukin 1 receptor type 1
Alias: CD121A, D2S1473, IL-1R-alpha, IL1R, IL1RA, P80, interleukin-1 receptor type 1, CD121 antigen-like family member A, IL-1R-1, IL-1RT-1, IL-1RT1, interleukin 1 receptor alpha, type I, interleukin-1 receptor alpha, interleukin-1 receptor type I
Species: human

Top Publications

  1. pmc Central interleukin-1 (IL1) signaling is required for pharmacological, but not physiological, effects of leptin on energy balance
    Brent E Wisse
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Harborview Medical Center, University of Washington, Seattle, WA 98108, USA
    Brain Res 1144:101-6. 2007
  2. doi The human Ku autoantigen shares amino acid sequence homology with fungal, but not bacterial and viral, proteins
    Fabrizio Guarneri
    Department of Territorial Social Medicine, Section of Dermatology, University of Messina, Messina, Italy
    Immunopharmacol Immunotoxicol 33:329-33. 2011
  3. ncbi IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family
    H Wesche
    Tularik Inc, South San Francisco, California 94080, USA
    J Biol Chem 274:19403-10. 1999
  4. doi Free fatty acids induce a proinflammatory response in islets via the abundantly expressed interleukin-1 receptor I
    Marianne Böni-Schnetzler
    Division of Endocrinology, Department of Medicine, University Hospital, CH 8091 Zurich, Switzerland marianne
    Endocrinology 150:5218-29. 2009
  5. pmc Regulating human Th17 cells via differential expression of IL-1 receptor
    Won Woo Lee
    Department of Internal Medicine Yale University School of Medicine, New Haven, CT, USA
    Blood 115:530-40. 2010
  6. ncbi MyD88, an adapter protein involved in interleukin-1 signaling
    K Burns
    Institute of Biochemistry, Lausanne Branch, University of Lausanne, Switzerland
    J Biol Chem 273:12203-9. 1998
  7. ncbi Ethnic differences in allelic associations of the interleukin-1 gene cluster in South African patients with inflammatory bowel disease (IBD) and in control individuals
    O Mwantembe
    Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa
    Immunogenetics 52:249-54. 2001
  8. ncbi Bone mineral mass is associated with interleukin 1 receptor autoantigen and TNF-alpha gene polymorphisms in post-menopausal Mediterranean women
    R Fontova
    University Hospital of Tarragona Joan XXIII, Medicine and Surgery Department, Spain
    J Endocrinol Invest 25:684-90. 2002
  9. doi Down syndrome candidate region-1 protein interacts with Tollip and positively modulates interleukin-1 receptor-mediated signaling
    Jae Youn Lee
    Department of Biology, College of Life Science and Biotechnology, Yonsei University, Seoul 120 749, Korea
    Biochim Biophys Acta 1790:1673-80. 2009
  10. pmc Lipid rafts and caveolin-1 coordinate interleukin-1beta (IL-1beta)-dependent activation of NFkappaB by controlling endocytosis of Nox2 and IL-1beta receptor 1 from the plasma membrane
    Fredrick D Oakley
    Department of Anatomy and Cell Biology, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 284:33255-64. 2009

Research Grants

  1. Mechanisms of abnormal enterochromaffin cell secretion in Crohn's disease
    Mark S Kidd; Fiscal Year: 2012
  2. Experimental Molecular Vaccines for Schistosomiasis
    Afzal A Siddiqui; Fiscal Year: 2012
  3. Alcohol, Glial Gene Expression and the Heat Shock Pathway
    Neil L Harrison; Fiscal Year: 2010
  4. DEAN YAW LI; Fiscal Year: 2016
  5. Caroline A Genco; Fiscal Year: 2014
  6. DELIVERY OF THERAPEUTIC GENES TO HUMAN RHEUMATOID JOINTS
    Christopher Evans; Fiscal Year: 2000
  7. WEN FAN HU; Fiscal Year: 2014
  8. Adult neurobiology following adolescent drinking
    Ryan Peter Vetreno; Fiscal Year: 2013
  9. Targeting Glial mGluR5 in Schizophrenia
    Francesca Cicchetti; Fiscal Year: 2013
  10. Synthetic TIR Domain Mimetics as a Novel Strategy for Intervention in Sepsis
    Julius Rebek; Fiscal Year: 2010

Detail Information

Publications290 found, 100 shown here

  1. pmc Central interleukin-1 (IL1) signaling is required for pharmacological, but not physiological, effects of leptin on energy balance
    Brent E Wisse
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Harborview Medical Center, University of Washington, Seattle, WA 98108, USA
    Brain Res 1144:101-6. 2007
    ..this hypothesis, we investigated whether chronic hypothalamic over-expression of an IL1 receptor antagonist (AdV-IL1ra) alters food intake and weight gain in normal rats...
  2. doi The human Ku autoantigen shares amino acid sequence homology with fungal, but not bacterial and viral, proteins
    Fabrizio Guarneri
    Department of Territorial Social Medicine, Section of Dermatology, University of Messina, Messina, Italy
    Immunopharmacol Immunotoxicol 33:329-33. 2011
    ....
  3. ncbi IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family
    H Wesche
    Tularik Inc, South San Francisco, California 94080, USA
    J Biol Chem 274:19403-10. 1999
    ..The discovery of IRAK-M adds another level of complexity to our understanding of signaling by members of the Toll/IL-1 receptor family...
  4. doi Free fatty acids induce a proinflammatory response in islets via the abundantly expressed interleukin-1 receptor I
    Marianne Böni-Schnetzler
    Division of Endocrinology, Department of Medicine, University Hospital, CH 8091 Zurich, Switzerland marianne
    Endocrinology 150:5218-29. 2009
    ..We conclude that FFA and TLR stimulation induce proinflammatory factors in islets and that IL-1RI engagement results in signal amplification...
  5. pmc Regulating human Th17 cells via differential expression of IL-1 receptor
    Won Woo Lee
    Department of Internal Medicine Yale University School of Medicine, New Haven, CT, USA
    Blood 115:530-40. 2010
    ..These results indicate that human Th17 cell differentiation is regulated via differential expression of IL-1RI, which is controlled by IL-7 and IL-15...
  6. ncbi MyD88, an adapter protein involved in interleukin-1 signaling
    K Burns
    Institute of Biochemistry, Lausanne Branch, University of Lausanne, Switzerland
    J Biol Chem 273:12203-9. 1998
    ..MyD88 coimmunoprecipitates with the IL-1R signaling complex in an IL-1-dependent manner...
  7. ncbi Ethnic differences in allelic associations of the interleukin-1 gene cluster in South African patients with inflammatory bowel disease (IBD) and in control individuals
    O Mwantembe
    Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa
    Immunogenetics 52:249-54. 2001
    ..0006 and P=0.0008, respectively). The population differences in allelic frequencies of the IL-1 gene cluster and IL-1Ra concentrations suggest that genetic and environmental factors play an important role in susceptibility to IBD...
  8. ncbi Bone mineral mass is associated with interleukin 1 receptor autoantigen and TNF-alpha gene polymorphisms in post-menopausal Mediterranean women
    R Fontova
    University Hospital of Tarragona Joan XXIII, Medicine and Surgery Department, Spain
    J Endocrinol Invest 25:684-90. 2002
    ..02). We conclude that both IL-1ra and TNF-alpha can be candidate loci to be studied in the susceptibility to develop post-menopausal osteoporosis...
  9. doi Down syndrome candidate region-1 protein interacts with Tollip and positively modulates interleukin-1 receptor-mediated signaling
    Jae Youn Lee
    Department of Biology, College of Life Science and Biotechnology, Yonsei University, Seoul 120 749, Korea
    Biochim Biophys Acta 1790:1673-80. 2009
    ..DSCR1 modulates calcineurin phosphatase activity, though its functional role is incompletely understood...
  10. pmc Lipid rafts and caveolin-1 coordinate interleukin-1beta (IL-1beta)-dependent activation of NFkappaB by controlling endocytosis of Nox2 and IL-1beta receptor 1 from the plasma membrane
    Fredrick D Oakley
    Department of Anatomy and Cell Biology, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 284:33255-64. 2009
    ..Our results fill in an important mechanistic gap in the understanding of early IL-1R1 and Nox2 signaling events that control NFkappaB activation, a redox-dependent process important in inflammation...
  11. pmc IL-1 receptor regulates S100A8/A9-dependent keratinocyte resistance to bacterial invasion
    B S Sorenson
    Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, Minnesota, USA
    Mucosal Immunol 5:66-75. 2012
    ..These data strongly suggest that infected epithelial cells release IL-1α to signal neighboring keratinocytes in a paracrine manner, promoting S100A8/A9-dependent resistance to invasive L. monocytogenes...
  12. pmc The E3 ubiquitin ligase MARCH8 negatively regulates IL-1β-induced NF-κB activation by targeting the IL1RAP coreceptor for ubiquitination and degradation
    Rui Chen
    State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China
    Proc Natl Acad Sci U S A 109:14128-33. 2012
    ..Our findings suggest that MARCH8-mediated polyubiquitination and degradation of IL1RAP is an important mechanism for negative regulation of IL-1β-induced signaling pathways...
  13. pmc Interleukin 1 signaling occurs exclusively via the type I receptor
    J E Sims
    Department of Molecular Biology, Immunex Research and Development Corporation, Seattle, WA 98101
    Proc Natl Acad Sci U S A 90:6155-9. 1993
    ..We conclude that a very small number of type I receptors is sufficient to mediate all of the actions of IL-1 which we have examined here and that the function of the type II receptor may not be to transduce signals...
  14. ncbi A new cytokine-receptor binding mode revealed by the crystal structure of the IL-1 receptor with an antagonist
    H Schreuder
    Marion Merrell Dow Research Institute, Strasbourg, France
    Nature 386:194-200. 1997
    ..ligands for the IL-1 receptor (IL1R) exist: the agonists IL-1alpha and IL-1beta and the IL-1-receptor antagonist IL1RA (ref. 2). IL-1 is the only cytokine for which a naturally occurring antagonist is known...
  15. ncbi Smoking and polymorphisms of the interleukin-1 gene cluster (IL-1alpha, IL-1beta, and IL-1RN) in patients with periodontal disease
    P Meisel
    Department of Pharmacology, Ernst Moritz Arndt University, Greifswald, Germany
    J Periodontol 73:27-32. 2002
    ..However, interactions of genetic with other risk factors, especially smoking, remain questionable. The aim of this cross-sectional study was to evaluate the genetic influence on periodontal variables in relation to environmental factors...
  16. ncbi SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling
    David Wald
    Cleveland Clinic Foundation, Department of Immunology, Cleveland, Ohio 44195, USA
    Nat Immunol 4:920-7. 2003
    ..Finally, biochemical analysis indicated that SIGIRR binds to the TLR-IL-1R signaling components in a ligand-dependent way. Our data show that SIGIRR functions as a biologically important modulator of TLR-IL-1R signaling...
  17. pmc Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein
    J Huang
    Tularik, Inc, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 94:12829-32. 1997
    ..Overexpression of an IL-1RAcP mutant lacking its intracellular domain, the IRAK-binding domain, prevented the recruitment of IRAK to the receptor complex and blocked IL-1-induced NF-kappaB activation...
  18. ncbi Characterization of a cascade of protein interactions initiated at the IL-1 receptor
    Jason A Boch
    Department of Medicine, Harvard Medical School, and the Beth Israel Deaconess Medical Center, Boston, MA, USA
    Biochem Biophys Res Commun 303:525-31. 2003
    ..A model is presented that reflects the specific molecular interactions responsible for recruiting signaling intermediates to the IL-1 receptor cytoplasmic domains...
  19. ncbi IL-1 cluster genes and occurrence of post-percutaneous transluminal coronary angioplasty restenosis: a prospective, angiography-based evaluation
    Robert Y L Zee
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215 1204, USA
    Atherosclerosis 171:259-64. 2003
    ..Our data indicate that the common variants in the IL-1 cluster genes are not associated with incidence of restenosis after PTCA...
  20. ncbi Functional correlates of the interleukin-1 receptor antagonist gene polymorphism in the colonic mucosa in ulcerative colitis
    M J Carter
    The Gastroenterology and Liver Unit, University of Sheffield, Royal Hallamshire Hospital, Sheffield, UK
    Genes Immun 5:8-15. 2004
    ..2-3.1) (P=0.018). The IL-1RN*2 is associated with reduced levels of IL-1ra protein and IL-1RN mRNA in the colonic mucosa, providing a biologically plausible explanation for the observed association of the allele with the disease...
  21. ncbi Interleukin-1 receptor antagonist gene polymorphism and rheumatoid arthritis
    Young Ho Lee
    Division of Rheumatology, Department of Internal Medicine, Anam Hospital, Korea University College of Medicine, 126 1 Ka, Anam Dong, Seongbuk Ku, Seoul 136 705, Korea
    Rheumatol Int 24:133-6. 2004
    ....
  22. ncbi Interleukin-1 gene cluster polymorphisms and alcoholism in Spanish men
    Isabel J Pastor
    Unidad de Medicina Molecular, Departamento de Medicina, Salamanca, Spain
    Alcohol Alcohol 40:181-6. 2005
    ..We analysed the distribution of single nucleotide polymorphisms (SNPs) located in the IL1A, IL1B, IL1R1 and IL1RN genes in alcoholic and non-alcoholic Spanish subjects.
  23. pmc FokI polymorphism, vitamin D receptor, and interleukin-1 receptor haplotypes are associated with type 1 diabetes in the Dalmatian population
    Tatijana Zemunik
    University of Split, School of Medicine, Department of Biology, Soltanska 2, 21000 Split, Croatia
    J Mol Diagn 7:600-4. 2005
    ..0064). Our findings indicate that the VDR FokI polymorphism and several VDR and IL-1-R1 haplotypes are associated with susceptibility to T1DM in the Dalmatian population...
  24. ncbi Interleukin-1 receptor antagonist gene VNTR polymorphism is associated with coronary artery disease
    Ahmet Arman
    Departamento de Cardiologia, Faculdade de Engenharia, Universidade Marmara, Istambul, Turquia
    Arq Bras Cardiol 91:293-8. 2008
    ..Atherosclerosis is an inflammatory disease. Cytokine gene variations such as those associated with the IL1 family are involved in the pathogenesis of atherosclerosis...
  25. pmc Variation in cytokine genes can contribute to severity of acetabular osteolysis and risk for revision in patients with ABG 1 total hip arthroplasty: a genetic association study
    Jiri Gallo
    Department of Orthopaedics, Teaching Hospital and Faculty of Medicine and Dentistry, Palacky University, I P Pavlova 6, Olomouc775 20, Czech Republic Laboratory of Immunogenomics, Faculty of Medicine and Dentistry, Palacky University, I P Pavlova 6, Olomouc 775 20, Czech Republic
    BMC Med Genet 10:109. 2009
    ..This may be driven by functional polymorphisms in the genes for cytokines and cytokine receptors involved in the development of osteolysis in THA, thereby having an effect on the individual's phenotype...
  26. doi Interleukin 1 receptor antagonist polymorphisms are associated with the risk of developing acute coronary syndrome in Mexicans
    José Manuel Fragoso
    Department of Molecular Biology and Cardiovascular Disease s Genomic and Proteomic Study Group, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico
    Immunol Lett 133:106-11. 2010
    ..Patients with ACS showed increased frequency of "T1C" haplotype when compared to healthy controls. The results suggest that IL-1RN gene polymorphisms could be involved in the risk of developing ACS in Mexican individuals...
  27. doi Polymorphisms in VEGF, progesterone receptor and IL-1 receptor genes in women with recurrent spontaneous abortion
    Evelyn Traina
    Obstetrics Departament, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    J Reprod Immunol 88:53-7. 2011
    ..Although we did not find any correlations, the investigation of these and other polymorphisms remains a challenge in the evaluation of RSA...
  28. pmc Structure of the activating IL-1 receptor signaling complex
    Christoph Thomas
    Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California, USA
    Nat Struct Mol Biol 19:455-7. 2012
    ....
  29. ncbi IRAK: a kinase associated with the interleukin-1 receptor
    Z Cao
    Molecular Biology Department, Tularik, Incorporated, South San Francisco, CA 94080, USA
    Science 271:1128-31. 1996
    ..The primary amino acid sequence of IRAK shares similarity with that of Pelle, a protein kinase that is essential for the activation of a NF-kappa B homolog in Drosophila...
  30. ncbi SIGIRR inhibits interleukin-1 receptor- and toll-like receptor 4-mediated signaling through different mechanisms
    Jinzhong Qin
    Department of Immunology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 280:25233-41. 2005
    ..These results indicate that SIGIRR inhibits IL-1 and LPS signaling pathways through differential mechanisms...
  31. ncbi The cell surface receptors for interleukin-1 alpha and interleukin-1 beta are identical
    S K Dower
    Nature 324:266-8. 1986
    ..This result raises the issue of what separation, if any, there might be between the biological activities of IL-1 alpha and IL-1 beta...
  32. ncbi Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor
    K Burns
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Centre, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nat Cell Biol 2:346-51. 2000
    ..As overexpression of Tollip results in impaired NF-kappaB activation, we conclude that Tollip is an important constituent of the IL-1R signalling pathway...
  33. ncbi Protective role against restenosis from an interleukin-1 receptor antagonist gene polymorphism in patients treated with coronary stenting
    A Kastrati
    Deutsches Herzzentrum München and 1 Medizinische Klinik rechts der Isar, Technische Universitat Munchen, Munich, Germany
    J Am Coll Cardiol 36:2168-73. 2000
    ..To test the hypothesis that interleukin-1 receptor antagonist (IL-1ra) gene polymorphism contributes to the risk of restenosis after coronary stenting...
  34. pmc Polymorphisms for interleukin-1 beta (IL-1 beta)-511 promoter, IL-1 beta exon 5, and IL-1 receptor antagonist: nonassociation with endometriosis
    Y Y Hsieh
    Department of Obstetrics and Gynecology, China Medical College Hospital, Taichung, Taiwan
    J Assist Reprod Genet 18:506-11. 2001
    ..We aimed to investigate if interleukin-1 beta (IL-1 beta) and IL-1 receptor antagonist (IL-1Ra) gene polymorphism could be used as markers of susceptibility in endometriosis...
  35. ncbi The epistatic interrelationships of IL-1, IL-1 receptor antagonist, and the type I IL-1 receptor
    Vera M Irikura
    Department of Biochemistry and Molecular Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Immunol 169:393-8. 2002
    ..These results support the model that the only essential function of IL-1ra in both health and disease is competitive inhibition of the IL-1RI...
  36. ncbi Interleukin 1 receptor antagonist gene polymorphism is associated with severe renal involvement and renal sequelae in Henoch-Schönlein purpura
    Mahsa M Amoli
    ARC Epidemiology Unit, Manchester University Medical School, United Kingdom
    J Rheumatol 29:1404-7. 2002
    ....
  37. ncbi Association of interleukin-1 receptor antagonist gene polymorphism with IgA nephropathy
    Makoto Watanabe
    First Department of Internal Medicine, Nara Medical University, Nara, Japan
    Nephron 91:744-6. 2002
    ..01). Our results suggest that IL-1ra polymorphisms are not associated with the development of IgAN in Japanese patients but the presence of IL1RN*2 may be associated with increased disease activity...
  38. ncbi Polymorphisms in interleukin-1beta and interleukin-1 receptor antagonist genes and malaria in Ghanaian children
    B Gyan
    Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana
    Scand J Immunol 56:619-22. 2002
    ..01). The mean parasitaemia in an age-matched asymptomatic group did not reveal such associations. These data suggest that IL-1beta exon 5 allele 2 may play a possible role in the clinical outcome of uncomplicated malaria...
  39. ncbi Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex
    Zhengfan Jiang
    Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 278:10952-6. 2003
    ..The Pellino 1-IRAK-IRAK4-TRAF6 signaling complex is likely to be intermediate, located between the IL-1 receptor complex and the TAK1 complex in the IL-1 pathway...
  40. ncbi A role for the interleukin-1 receptor in the pathway linking static mechanical compression to decreased proteoglycan synthesis in surface articular cartilage
    Minako Murata
    Orthopaedic Research Laboratories, Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Arch Biochem Biophys 413:229-35. 2003
    ..The data support a role for the IL-1 receptor in the pathway linking static compression to reduced proteoglycan synthesis...
  41. ncbi Interleukin 1alpha, interleukin 1beta and interleukin 1 receptor gene polymorphisms in psoriatic arthritis
    J S Ravindran
    Royal National Hospital for Rheumatic Diseases, Bath, UK
    Rheumatology (Oxford) 43:22-6. 2004
    ..To investigate polymorphisms of interleukin (IL) 1alpha, IL-1beta and IL-1 receptor R1 genes in patients with psoriatic arthritis (PsA), their relationship to the age of onset of psoriasis and the pattern of joint involvement...
  42. ncbi Down-regulation of interleukin-1 receptor type 1 expression causes the dysregulated expression of CXC chemokines in endometriotic stromal cells: a possible mechanism for the altered immunological functions in endometriosis
    Masakazu Nishida
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Hasama machi, Oita 879 5593, Japan
    J Clin Endocrinol Metab 89:5094-100. 2004
    ..The alteration of the CXC chemokines expression may be important for elucidation of the pathogenesis of endometriosis...
  43. ncbi Genotypes and haplotypes in the IL-1 gene cluster: analysis of two genetically and diagnostically distinct groups of Alzheimer patients
    Davide Seripa
    Laboratory of Gene Therapy, I R C C S Casa Sollievo della Sofferenza, Padre Pio da Pietrelcina Foundation, San Giovanni Rotondo, FG, Italy
    Neurobiol Aging 26:455-64. 2005
    ....
  44. pmc A novel splice variant of interleukin-1 receptor (IL-1R)-associated kinase 1 plays a negative regulatory role in Toll/IL-1R-induced inflammatory signaling
    Navin Rao
    Johnson and Johnson Pharmaceutical Research and Development, 3210 Merryfield Row, San Diego, CA 92121, USA
    Mol Cell Biol 25:6521-32. 2005
    ....
  45. ncbi Alteration on the expression of IL-1, PDGF, TGF-beta, EGF, and FGF receptors and c-Fos and c-Myc proteins in bone marrow mesenchymal stroma cells from advanced untreated lung and breast cancer patients
    Erica Leonor Hofer
    Instituto de Biologia y Medicina Experimental, Buenos Aires, Argentina
    Stem Cells Dev 14:587-94. 2005
    ..The alterations we describe could help to explain the deficiency regarding the proliferative and confluence capacity of BM stroma cells in cancer patients...
  46. ncbi Action of intracellular IL-1Ra (Type 1) is independent of the IL-1 intracellular signalling pathway
    Iona Evans
    Section of Functional Genomics, Division of Genomic Medicine, Royal Hallamshire Hospital, Glossop Road, Sheffield, S10 2JF, UK
    Cytokine 33:274-80. 2006
    ..These results suggest that icIL-1ra1 does not act at an intracellular level to alter IL-1 mediated signalling, and is effective in inhibiting IL-1 responses only when released in an ATP-dependent and cell type specific manner...
  47. ncbi Intracellular trafficking of interleukin-1 receptor I requires Tollip
    Brian Brissoni
    Department of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Curr Biol 16:2265-70. 2006
    ..Our findings suggest that Tollip functions as an endosomal adaptor linking IL-1RI, via Tom1, to the endosomal degradation machinery...
  48. ncbi Abnormal interleukin 1 receptor types I and II gene expression in eutopic and ectopic endometrial tissues of women with endometriosis
    Christine Lawson
    Hôpital Saint François d Assise HSFA, Centre Hospitalier Universitaire de Quebec CHUQ, Quebec, Canada
    J Reprod Immunol 77:75-84. 2008
    ..IL1 triggers cell activation via its receptor type I (IL1R1), but its receptor type II (IL1R2) is known instead as a scavenger that buffers the cytokine's effects...
  49. doi Interleukin-1 system in the human fallopian tube-No spatial but a temporal regulation of mRNA and protein expression
    A P Hess
    Department of Gynecology and Obstetrics, Heinrich Heine University Medical Center, Duesseldorf, Germany
    Mol Cell Endocrinol 303:7-12. 2009
    ....
  50. doi Interleukin-1 receptor antagonist gene (IL1RN) polymorphism possibly associated to severity of rheumatic carditis in a Brazilian cohort
    Pedro Ming Azevedo
    Rheumatology Division, Faculdade de Medicina da Universidade de Sao Paulo, CEP 01246903 Sao Paulo, SP, Brazil
    Cytokine 49:109-13. 2010
    ..To evaluate the IL1RN polymorphism as a possible marker for Rheumatic Fever (RF) susceptibility or disease severity...
  51. pmc Expression and function of TNF and IL-1 receptors on human regulatory T cells
    Frances Mercer
    Department of Microbiology, New York University School of Medicine, New York, New York, United States of America
    PLoS ONE 5:e8639. 2010
    ..In conclusion, our findings that human Tregs preferentially express receptors for TNF and IL-1 suggest a potential function in sensing and dampening local inflammation...
  52. ncbi Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta
    G P Vigers
    Amgen Inc, Boulder, Colorado 80301, USA
    Nature 386:190-4. 1997
    ..Each of these molecules binds to the type I IL-1 receptor (IL1R)...
  53. ncbi IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling
    M Muzio
    University of Michigan Medical School, Department of Pathology, Ann Arbor, MI 48109, USA
    Science 278:1612-5. 1997
    ..Dominant negative forms of either attenuate IL-1R-mediated NF-kappaB activation. Therefore, IRAK-2 and MyD88 may provide additional therapeutic targets for inhibiting IL-1-induced inflammation...
  54. ncbi Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q
    M Dale
    Division of Molecular and Genetic Medicine, University of Sheffield, Royal Hallamshire Hospital, Sheffield, S10 2JF, United Kingdom
    Genomics 57:177-9. 1999
    ..gt; tel), in the order given, for the type II interleukin-1 (IL-1) receptor (IL1R2), the type I IL-1 receptor (IL1R1), the IL-1 receptor-related protein 2 (IL1RL2), T1/ST2/fit-1 (IL1RL1), and the IL-1 receptor-related protein 1, ..
  55. ncbi Association of genotypes affecting the expression of interleukin-1beta or interleukin-1 receptor antagonist with osteoarthritis
    V Moos
    Deutsches Rheuma Forschungs Zentrum, and Klinikum Benjamin Franklin, Free University, Berlin, Germany
    Arthritis Rheum 43:2417-22. 2000
    ..To establish a hierarchy among the cytokines and growth factors expressed in articular chondrocytes, this study investigated cytokine genes for known polymorphisms that may contribute to the deregulated expression in OA cartilage...
  56. ncbi Interleukin-1 gene cluster polymorphisms in sarcoidosis and idiopathic pulmonary fibrosis
    Beata Hutyrova
    Departments of Immunology, Biology, and Respiratory Medicine, Palacky University, Olomouc, Czech Republic
    Am J Respir Crit Care Med 165:148-51. 2002
    ..Further population studies are warranted to confirm the observed association between sarcoidosis and the IL-1alpha polymorphism and also to explore mechanisms of IL-1alpha -889 participation in aberrant immune response in sarcoidosis...
  57. ncbi Extended haplotypes and linkage disequilibrium in the IL1R1-IL1A-IL1B-IL1RN gene cluster: association with knee osteoarthritis
    A J P Smith
    University of Bristol Department of Pathology and Microbiology, Homoeopathic Hospital Site, Cotham, Bristol, UK
    Genes Immun 5:451-60. 2004
    ..We explored the linkage between nine polymorphic loci in the IL1R1 promoter, eight in the IL1A-IL1B-IL1RN gene complex, and their association with osteoarthritis (OA), a common ..
  58. ncbi A functional polymorphism in the interleukin-1 receptor-1 gene is associated with increased risk of Helicobacter pylori infection but not with gastric cancer
    Steve Hartland
    School of Clinical Medical Sciences, The Medical School, University of Newcastle, Newcastle upon Tyne, UK
    Dig Dis Sci 49:1545-50. 2004
    ..The major novel finding of the study was a marked difference in the genotype frequencies for the IL1R1 Hinfl SNP in those with current or previous evidence of H. pylori compared to those without...
  59. ncbi Polymorphisms in exons 1B and 1C of the type I interleukin-1 receptor gene in patients with endometriosis
    Paulo D'Amora
    Molecular Gynecology Laboratory, Gynecology Department, Federal University of Sao Paulo, Escola Paulista de Medicina, Sao Paulo, Brazil
    Am J Reprod Immunol 56:178-84. 2006
    ..058). However, in relation to BsrBI polymorphism, protective risk was observed for the development of endometriosis [OR 0.39-IC 95% (0.2-0.9)]. BsrBI heterozygote genotype (C/A) showed protective effect against endometriosis development...
  60. ncbi Exhaustive genotyping of the interleukin-1 family genes and associations with AIDS progression in a French cohort
    Herve Do
    Centre National de Genotypage, Evry, Conservatoire National des Arts et Metiers, Paris, France
    J Infect Dis 194:1492-504. 2006
    ..To better evaluate the impact of the IL-1 family on AIDS development, we genotyped the IL1 alpha , IL1 beta , IL1Ra, and IL1R1 genes in 245 slow progressor (SP) and 82 rapid progressor (RP) human immunodeficiency virus type 1-..
  61. ncbi Imbalance in the expression of the activating type I and the inhibitory type II interleukin 1 receptors in endometriosis
    Ali Akoum
    Unite d Endocrinologie de la Reproduction, Centre de Recherche, Hopital Saint Francois d Assise, Centre Hospitalier Universitaire de Quebec, Canada
    Hum Reprod 22:1464-73. 2007
    ..The objective of this study was to further evaluate the expression and significance of IL1 receptor type I (IL1R1), the signalling receptor that mediates cell activation by IL1, and IL1 receptor type II (IL1R2), a potent and ..
  62. ncbi Single nucleotide polymorphisms of cytokine genes in the healthy Slovak population
    J Javor
    Department of Immunology, School of Medicine, Comenius University, Saskinova 4, 811 08 Bratislava, Slovakia
    Int J Immunogenet 34:273-80. 2007
    ..However, several differences were found between the Slovak and four populations from Southern Europe. The obtained data represent a basis for further studies on association of cytokine gene polymorphisms with some diseases...
  63. doi Association between interleukin 1 gene cluster polymorphisms and bilateral distal interphalangeal osteoarthritis
    Svetlana Solovieva
    Centre of Expertise Health and Work Ability, Finnish Institute of Occupational Health, Helsinki, Finland
    J Rheumatol 36:1977-86. 2009
    ..To examine the association of the interleukin 1 gene (IL1) cluster polymorphisms and their haplotypes with bilateral distal interphalangeal joint osteoarthritis (DIP OA)...
  64. doi Interleukin-1 receptor-like 1 polymorphisms are associated with serum IL1RL1-a, eosinophils, and asthma in childhood
    Olga E M Savenije
    Departments of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Allergy Clin Immunol 127:750-6.e1-5. 2011
    ..Single nucleotide polymorphisms (SNPs) in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in family-based and case-control studies...
  65. ncbi Different pattern of interleukin-1 beta-(IL-1 beta), interleukin-1 receptor antagonist- (IL-1ra) and interleukin-1 receptor type I- (IL-1R tI) mRNA-expression in single preimplantation mouse embryos at various developmental stages
    J S Kruessel
    Department of Gynecology and Obstetrics, Stanford University School of Medicine, Palo Alto, California 94304, USA
    J Reprod Immunol 34:103-20. 1997
    ..IL-1R tI) in human preimplantation embryos and protein levels of interleukin-1 alpha (IL-1 alpha), IL-1 beta and IL1ra in human preimplantation embryo culture fluid have been correlated with successful implantation and pregnancy...
  66. doi Hyperalgesia, synovitis and multiple biomarkers of inflammation are suppressed by interleukin 1 inhibition in a novel animal model of gouty arthritis
    R Torres
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Rd, Tarrytown, NY 10591, USA
    Ann Rheum Dis 68:1602-8. 2009
    ..However, consequences of IL1 inhibition have not been explored in more clinically relevant models of crystal-induced arthritis...
  67. pmc Effects of treatment with a fully human anti-tumour necrosis factor alpha monoclonal antibody on the local and systemic homeostasis of interleukin 1 and TNFalpha in patients with rheumatoid arthritis
    P Barrera
    Department of Rheumatology, University Hospital, Nijmegen, The Netherlands
    Ann Rheum Dis 60:660-9. 2001
    ....
  68. ncbi Differential effects of interleukin 1-alpha (IL-1 alpha) or tumor necrosis factor-alpha (TNF-alpha) on motility of human melanoma cell lines on fibronectin
    S K Dekker
    Department of Pathology, Harvard Medical School, Boston, Massachusetts
    J Invest Dermatol 102:898-905. 1994
    ..Scant p80 TNF receptor expression was detected on only one cell line...
  69. doi Interleukin 1 regulates its own receptors in human endometrial cells via distinct mechanisms
    C Bellehumeur
    Unite d Endocrinologie de la Reproduction, Centre de Recherche, Hopital Saint Francois d Assise, Centre Hospitalier Universitaire de Quebec, 10 rue de l Espinay, Local D0 711, Quebec, Quebec, Canada
    Hum Reprod 24:2193-204. 2009
    ..The coordinated regulation of IL1 receptors types I and II (IL1R1 and IL1R2) and IL1 receptor antagonist (IL1RA) in endometrial cells may represent one of the principle mechanisms ..
  70. ncbi Assessment of the interleukin 1 gene cluster and other candidate gene polymorphisms in host susceptibility to tuberculosis
    R Bellamy
    Wellcome Trust Centre for Human Genetics, Oxford University, UK
    Tuber Lung Dis 79:83-9. 1998
    ..A study of tuberculosis cases and healthy blood donor controls from the Western Region of The Gambia, West Africa...
  71. pmc Role of interleukin 1 and interleukin 1 receptor antagonist in the mediation of rheumatoid arthritis
    M H Schiff
    Denver Arthritis Clinic, 4545 E 9th Avenue, Suite 510, Denver, CO 80220, USA
    Ann Rheum Dis 59:i103-8. 2000
    ..Interleukin 1 receptor antagonist (IL1Ra) selectively inhibits the effects of IL1 by competing for the IL1 receptor on all surfaces of the synovium...
  72. pmc Gait and behavior in an IL1β-mediated model of rat knee arthritis and effects of an IL1 antagonist
    Kyle D Allen
    Department of Orthopaedic Surgery, Duke University Medical Center, Duke University, Durham, North Carolina, USA
    J Orthop Res 29:694-703. 2011
    ..from IL1β over-expression in the rat knee and to investigate the ability of local IL1 receptor antagonist (IL1Ra) delivery to reverse-associated pathology...
  73. ncbi Association between interleukin-1 receptor antagonist gene and asthma-related traits in a German adult population
    C Pattaro
    Unit of Epidemiology and Medical Statistics, Department of Medicine and Public Health, Istituti Biologici II, University of Verona, Verona, Italy
    Allergy 61:239-44. 2006
    A recent study in German and Italian families associated variants in the interleukin-1 receptor antagonist (IL1RA) gene with asthma...
  74. pmc Ex vivo interleukin 1 receptor antagonist production on lipopolysaccharide stimulation is associated with rheumatoid arthritis and with joint damage
    J K de Vries-Bouwstra
    Department of Rheumatology, VU University Medical Center, Amsterdam, The Netherlands
    Ann Rheum Dis 66:1033-7. 2007
    1) To assess innate ex vivo production of interleukin 1beta (IL1beta) and interleukin 1 receptor antagonist (IL1Ra) in patients with recent-onset rheumatoid arthritis (RA) as compared with healthy controls; (2) to assess the association ..
  75. doi Polymorphism of the interleukin 1 receptor antagonist (IL1Ra) gene and placental abruption
    E Jaaskelainen
    Department of Obstetrics and Gynaecology, University Hospital of Kuopio, Kuopio 70211, Finland
    J Reprod Immunol 79:58-62. 2008
    ..The polymorphic allele A2 in the gene coding for interleukin 1 receptor antagonist (IL1Ra) has been associated in various diseases of autoimmune or inflammatory nature...
  76. pmc Acute hepatitis in three patients with systemic juvenile idiopathic arthritis taking interleukin-1 receptor antagonist
    Scott Canna
    Division of Rheumatology, The Children s Hospital, 13123 E 16th Ave, Aurora, CO 80045, USA
    Pediatr Rheumatol Online J 7:21. 2009
    We investigated the etiology of acute hepatitis in three children with systemic Juvenile Idiopathic Arthritis (sJIA) taking Interleukin-1 receptor antagonist (IL1RA).
  77. doi The genome of the sponge Amphimedon queenslandica provides new perspectives into the origin of Toll-like and interleukin 1 receptor pathways
    Marie E A Gauthier
    School of Biological Sciences, University of Queensland, Brisbane, QLD 4072, Australia
    Evol Dev 12:519-33. 2010
    Members of the Toll-like receptor (TLR) and the interleukin 1 receptor (IL1R) superfamilies activate various signaling cascades that are evolutionarily conserved in eumetazoans...
  78. ncbi Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL 1R-rp2)
    T W Lovenberg
    Neurocrine Biosciences Inc, San Diego, CA 92121, USA
    J Neuroimmunol 70:113-22. 1996
    ..We have named this protein interleukin 1 receptor related protein two (IL 1R-rp2). The rat cDNA for IL1R-rp2 was first identified using oligonucleotides of degenerate sequence in a polymerase chain reaction (PCR) ..
  79. ncbi Adenoviral overproduction of interleukin-1 receptor antagonist increases beta cell replication and mass in syngeneically transplanted islets, and improves metabolic outcome
    N Tellez
    Laboratory of Diabetes and Experimental Endocrinology, Department of Clinical Sciences, University of Barcelona, L Hospitalet de Llobregat, Barcelona, Spain
    Diabetologia 50:602-11. 2007
    Interleukin-1 receptor antagonist (IL1RN, also known as IL1RA) is a naturally occurring inhibitor of IL-1 action and its overproduction protects pancreatic islets from the deleterious effects of IL-1beta on beta cell replication, ..
  80. pmc Anchorage mediated by integrin alpha6beta4 to laminin 5 (epiligrin) regulates tyrosine phosphorylation of a membrane-associated 80-kD protein
    Y Xia
    Department of Cell Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
    J Cell Biol 132:727-40. 1996
    ..We identified a novel 80-kD membrane-associated protein (p80) that is tyrosine phosphorylated in response to dissociation of alpha6beta4 from laminin 5...
  81. pmc Associations between cytokine/cytokine receptor single nucleotide polymorphisms and humoral immunity to measles, mumps and rubella in a Somali population
    N Dhiman
    Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA
    Tissue Antigens 72:211-20. 2008
    ..IL2RA and B) and Th2 (IL4R and IL10RB) immunity, and cytokine (IL1B, TNFA, IL6 and IFNB1) and cytokine receptor (IL1RA, IFNAR2, IL18R1, TNFRSF1A and B) genes regulating innate immunity and variations in antibody levels to measles, ..
  82. pmc HinT proteins and their putative interaction partners in Mollicutes and Chlamydiaceae
    Miriam Hopfe
    Institute of Medical Microbiology, Moorenstrasse 5, 40225 Duesseldorf, Germany
    BMC Microbiol 5:27. 2005
    ..In Mycoplasma hominis, HinT is concomitantly expressed with the proteins P60 and P80, two domains of a surface exposed membrane complex, and in addition interacts with the P80 moiety.
  83. doi Epidemiology of Pestivirus infection in wild ungulates of the French South Alps
    Claire Martin
    Department of Infectious and Parasitic Diseases, Epidemiology and Risk Analysis Applied to Veterinary Sciences UREAR, Faculty of Veterinary Medicine, University of Liege, Boulevard de Colonster, 20, B42, B 4000 Liege, Belgium
    Vet Microbiol 147:320-8. 2011
    ..Pestivirus-specific antibodies against p80 protein (also named NS3) common to all Bovine Viral Diarrhea Virus (BVDV) and Border Disease Virus (BDV) were found ..
  84. ncbi Surface expression of heterogeneous nuclear RNA binding protein M4 on Kupffer cell relates to its function as a carcinoembryonic antigen receptor
    Olga Bajenova
    Department of Surgery, Boston University School of Medicine, 801 Albany Street, Boston, MA 02118, USA
    Exp Cell Res 291:228-41. 2003
    ..HnRNP M4 has two isoform proteins (p80, p76), the full-length hnRNP M4 (CEARL) and a truncated form (CEARS) with a deletion of 39 amino acids between RNA ..
  85. pmc Association of herpesvirus saimiri tip with lipid raft is essential for downregulation of T-cell receptor and CD4 coreceptor
    Nam Hyuk Cho
    Department of Microbiology and Molecular Genetics and Tumor Virology Division, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772 9102, USA
    J Virol 80:108-18. 2006
    ..tumor virus, is constitutively targeted to lipid rafts and interacts with cellular Lck tyrosine kinase and p80 WD repeat-containing endosomal protein...
  86. ncbi Interleukin 1 in oviductal tissues of viviparous, oviparous, and ovuliparous species of amphibians
    Silke Jantra
    Department of Physiology, Division of Immunoendocrinology and Reproductive Physiology and Department of Evolutionary Biology, University of Siena, Via Aldo Moro, 53100 Siena, Italy
    Biol Reprod 76:1009-15. 2007
    ..In the present study, we investigated the expression of IL1B and its functional membrane receptor type I (IL1R1) in amphibians, a class of vertebrates that is characterized by different reproductive modes, including internal ..
  87. pmc Genome wide transcriptional analysis of resting and IL2 activated human natural killer cells: gene expression signatures indicative of novel molecular signaling pathways
    Karen Dybkaer
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA
    BMC Genomics 8:230. 2007
    ..We utilized genome-wide transcriptional profiling to identify gene expression signatures and pathways in resting and IL2 activated NK cell isolated from peripheral blood of healthy donors...
  88. ncbi Role of soluble receptors for tumor necrosis factor alpha in the development of hypoalbuminemia in hemodialysis patients
    Mari Odamaki
    First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Am J Nephrol 22:73-80. 2002
    ....
  89. doi In vitro susceptibility of genotypically distinct and clonal Clostridium difficile strains to oritavancin
    Rachael O'Connor
    Department of Microbiology, Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK
    J Antimicrob Chemother 62:762-5. 2008
    ..In agar incorporation methods, the impact of supplements on oritavancin MICs was tested to address oritavancin binding to surfaces...
  90. ncbi The collagen-like region of surfactant protein A (SP-A) is required for correction of surfactant structural and functional defects in the SP-A null mouse
    M Ikegami
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Cincinnati School of Medicine, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 276:38542-8. 2001
    ..promoter to drive expression of rat SP-A (rSPA) or SP-A containing a deletion of the collagen-like domain (DeltaG8-P80) in the Clara cells and alveolar type II cells of SP-A(-/-) mice...
  91. doi The therapeutic use of osmotic minipumps in the severe combined immunodeficiency (SCID) mouse model for rheumatoid arthritis
    A Knedla
    Department of Internal Medicine and Rheumatology, Justus Liebig University of Giessen, Department of Rheumatology and Clinical Immunology, Kerckhoff Klinik Bad Nauheim, Germany
    Ann Rheum Dis 68:124-9. 2009
    The viral gene transfer of interleukin 1 receptor antagonist (IL1ra) and interleukin 10 (IL10) into rheumatoid arthritis (RA) synovial fibroblasts (RASFs) has shown protective effects on cartilage destruction in the severe combined ..
  92. pmc Sm-p80-based DNA vaccine provides baboons with levels of protection against Schistosoma mansoni infection comparable to those achieved by the irradiated cercarial vaccine
    Weidong Zhang
    Department of 1Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
    J Infect Dis 201:1105-12. 2010
    ..Sm-p80 antigen is a promising vaccine target because of its documented immunogenicity, protective efficacy, and ..
  93. ncbi Nuclear gems and Cajal (coiled) bodies in fetal tissues: nucleolar distribution of the spinal muscular atrophy protein, SMN
    P J Young
    MRIC Biochemistry Group, North East Wales Institute, Mold Road, Wrexham LL11 2AW, United Kingdom
    Exp Cell Res 265:252-61. 2001
    ..Coilin-p80 is a marker protein for nuclear Cajal bodies (coiled bodies; CBs) which are also involved in snRNP maturation, ..
  94. ncbi Age-specific seroprevalence of Border disease virus and presence of persistently infected sheep in Basque dairy-sheep flocks
    E Berriatua
    Sanidad Animal, Instituto Vasco de Investigacion y Desarrollo Agrario NEIKER, Berreaga 1, Derio, Bizkaia 48160, Spain
    Vet J 168:336-42. 2004
    Using p125/p80 antibody and antigen-ELISA tests, age-specific seroprevalence and presence of persistently infected (PI) sheep were investigated in six commercial latxa dairy-flocks, housed for variable periods...
  95. ncbi Prevalence of Arcobacter species in market-weight commercial turkeys
    Michelle M E Andersen
    Poultry Science Department, University of Georgia, Athens, GA 30605, USA
    Antonie Van Leeuwenhoek 92:309-17. 2007
    ..Initially, EMJH-P80 and CVA isolated Arcobacter from 7...
  96. doi Oral microemulsions of paclitaxel: in situ and pharmacokinetic studies
    Adwoa O Nornoo
    Department of Pharmaceutical Sciences, Albany College of Pharmacy, Albany, NY 12208 3492, USA
    Eur J Pharm Biopharm 71:310-7. 2009
    ..15%)>capmul MCM: polysorbate 80: myvacet oil (CPM, 27.6%)>capryol 90: polysorbate 80: myvacet oil (CP-P80, 23.9%)>capmul: myvacet oil (CM, 20%)...
  97. ncbi Gradual loss of DNA-PK activity from the cytoplasm is coincident with the nuclear translocation of its activator Ku during early development of Xenopus laevis
    J Kanungo
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia, USA
    Folia Biol (Praha) 55:218-23. 2009
    ..kinase is a serine/ threonine kinase consisting of a catalytic subunit, p460, and a regulatory subunit called Ku (p80/p70). DNA-dependent protein kinase plays a role in transcription, non-homologous recombination, and DNA repair...
  98. ncbi Identification of lysine decarboxylase as a mammalian cell growth inhibitor in Eikenella corrodens: possible role in periodontal disease
    M Levine
    Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, P O Box 26901, Oklahoma City, Oklahoma, 73190, USA
    Microb Pathog 30:179-92. 2001
    ..Previous studies identified a protein (p80) as causing growth inhibition by E. corrodens extracts...
  99. doi The effects of concentrate added to pineapple (Ananas comosus Linn. Mer.) waste silage in differing ratios to form complete diets, on digestion, excretion of urinary purine derivatives and blood metabolites in growing, male, Thai swamp buffaloes
    T Jetana
    Research and Development Center for Livestock Production Technology, Faculty of Veterinary Science, Chulalongkorn University, Henri Dunant Street, Phathumwan, Bangkok 10330, Thailand
    Trop Anim Health Prod 41:449-59. 2009
    ..8:0.2 (P80:C20), 0.6:0.4 (P60:C40), 0.4:0.6 (P40:C60) and 0.2:0.8 (P20:C80)...
  100. ncbi A double monoclonal antibody ELISA for detecting pestivirus antigen in the blood of viraemic cattle and sheep
    G Entrican
    Moredun Research Institute, Edinburgh, UK
    Vet Microbiol 43:65-74. 1995
    A panel of monoclonal antibodies (mAbs) has been produced to the p125/p80 non-structural polypeptide of border disease virus (BDV) and bovine virus diarrhoea virus (BVDV)...
  101. ncbi Association between circulating leptin and soluble receptors for tumor necrosis factor-alpha in hemodialysis patients
    A Kato
    First Department of Medicine, Hamamatsu University School of Medicine, Japan
    Clin Nephrol 56:370-7. 2001
    ..Since circulating leptin levels adjusted for body fat mass are reported to be increased in dialysis patients, we examined if the TNF-alpha system may influence blood leptin levels in hemodialysis (HD) patients...

Research Grants55

  1. Mechanisms of abnormal enterochromaffin cell secretion in Crohn's disease
    Mark S Kidd; Fiscal Year: 2012
    ..signaled secretory responses were reversed by LPS and IL1[unreadable] receptor antagonists (K12 LPS and IL1RA) and inhibited (80%) by a somatostatin analog in human samples...
  2. Experimental Molecular Vaccines for Schistosomiasis
    Afzal A Siddiqui; Fiscal Year: 2012
    ..Our previous studies using the vaccine candidate Sm-p80 has shown that its efficacy can be improved by the addition of DNA encoding immunomodulatory cytokines (IL-2 and IL-..
  3. Alcohol, Glial Gene Expression and the Heat Shock Pathway
    Neil L Harrison; Fiscal Year: 2010
    ..We will study the effects of alcohol on the expression of cytokine IL-1b (Il1b), the cytokine receptors, IL-1R1 (Il1r1) and TLR4 (Tlr4) and the enzymes iNOS (Nos2) and COX-2 (COX2) in a MCG cell line...
  4. DEAN YAW LI; Fiscal Year: 2016
    ..influences on the endothelial barrier of, respectively, the Robo1 receptor and the receptor for interleukin-1b (IL1R)...
  5. Caroline A Genco; Fiscal Year: 2014
    ..While several TLRs were detected in platelets, the expression of TLR2 and IL1R in particular were increased in patients with cardiovascular disease...
  6. DELIVERY OF THERAPEUTIC GENES TO HUMAN RHEUMATOID JOINTS
    Christopher Evans; Fiscal Year: 2000
    ..strategy employing a retrovirus (MFG-IRAP) and autologous synovial fibroblasts, it proved possible to transfer the IL1Ra gene to rheumatoid joints and to express them within those joints...
  7. WEN FAN HU; Fiscal Year: 2014
    ..Together, these experiments will provide further insights into the mechanisms regulating neuronal progenitor proliferation during normal cortical development and how their deregulation causes developmental neurological disorders. ..
  8. Adult neurobiology following adolescent drinking
    Ryan Peter Vetreno; Fiscal Year: 2013
    ..brain integrity, cortical thickness, white matter tracts, and regional volumes in adolescent (P56) and adult (P80) rats (Aim 1)...
  9. Targeting Glial mGluR5 in Schizophrenia
    Francesca Cicchetti; Fiscal Year: 2013
    ..expression using [18F]FPEB, combined by behavioral studies, will be done at two time points (p35 (pre- puberty) and p80 (adulthood)) to relate the time course of inflammation to motor dysfunction and the extent of inflammatory response/..
  10. Synthetic TIR Domain Mimetics as a Novel Strategy for Intervention in Sepsis
    Julius Rebek; Fiscal Year: 2010
    ..a new principle for modifying innate immune signaling through targeting the central adaptor interface of the TLR/IL1R superfamily with small, synthetic compounds...
  11. DAT QUOC TRAN; Fiscal Year: 2016
    ..of Treg repertoire, subsets and function for patients with allo-HCT who will develop cGHVD, 2) the function of CD121a and CD121b on LAP+ Tregs, and 3) the stability and potency of these LAP+ Tregs...
  12. Toll-like receptor 9 proteolytic processing and signaling
    Cynthia A Leifer; Fiscal Year: 2013
    ..This cleavage removes an N-terminal fragment, leaving a C-terminal fragment, called p80, which is proposed to be the functional form of TLR9...
  13. Afzal A Siddiqui; Fiscal Year: 2014
    ..Over the last twenty years, we have applied this strategy towards developing Sm-p80 into a viable vaccine candidate...
  14. Viral-Driven Mediators of Chronic Lung Allograft Dysfunction
    Richard Pierce; Fiscal Year: 2009
    ..resulted in a synergistic increase in the expression of the epithelial cell injury-response cytokine IL-12 p80 (p80), a macrophage chemoattractant...
  15. QUANTITATIVE CARCINOGENESIS IN CULTURED EPITHELIAL CELLS
    Molly Kulesz Martin; Fiscal Year: 2002
    ..Experiments will include the characterization of two cellular factors, a p80 (which appears to be wild type conformation-specific and is not mdm2) and a p40 (which appears to be p53 ..
  16. CYCLOSPORINE, TGF BETA1, AND IMMUNOSUPPRESSION
    Manikkam Suthanthiran; Fiscal Year: 2002
    ..The CD4+ cells, and subsets of CD4+ cells (CD4+CD45R+, CD4+CD45R-, D4+Leu8+(p80+), CD4+p8O-, CD4+CD45R-p80+ r CD4+CD45R-p80- cells), CD8+ cells and subsets of CD8+ cells (CD8+CD1lb+ or CD8+CD1lb- ..
  17. IL-12 p80 Mediated Airway Inflammation
    Michael Walter; Fiscal Year: 2006
    ..proposal is based on several novel findings related to a member of the interleukin (IL)-12 family, called IL-12 p80 (p80)...
  18. Thermally-Induced Intra-Articular Drug Delivery System
    Lori Setton; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): The anti-inflammatory drugs, IL-1 receptor antagonist (IL1Ra) and TNF-alpha blocking antibodies, have been shown to dramatically modify the progression of inflammatory joint disease...
  19. NF-KB-2 GENE REARRANGEMENT IN CUTANEOUS T-CELL LYMPHOMAS
    Arnold Rabson; Fiscal Year: 1999
    ..In HUT 78 cells, nfkb-2 gene rearrangement results in generation of a truncated p80 precursor protein (p80HT) as well as the mature p52 protein...
  20. MOLECULAR MECHANISMS OF METALLOTHIONEIN INDUCTION
    Samson Jacob; Fiscal Year: 2003
    ..Furthermore, tumor cells that do not expresss MT and exhibit higher levels of P80 compared to p70 will be investigated...
  21. Herpesvirus saimiri TIP
    Jae Jung; Fiscal Year: 2009
    ..Our biochemical analysis also demonstrates that Tip targets Lck tyrosine kinase, STAT transcription factor, p80 endosomal adaptor, and Vps35 retromer subunit to down regulate T cell receptor (TCR) signal transduction and to ..
  22. ERYTHROCYTE PROTEIN ANTIGENS REGULATED BY IN-LU
    Marilyn Telen; Fiscal Year: 1993
    ..The candidate has purified one protein (p80) regulated by In(Lu) and will partially sequence this protein in order to synthesize oligonucleotides with which to ..
  23. TNF-ALPHA AND ITS RECEPTORS IN PEDIATRIC ACUTE LEUKEMIA
    HARRY FINDLEY; Fiscal Year: 2000
    ..Both TNF+ and TNF- lines expressed p60 and p80 TNF receptors (TNFrs), suggesting that phenotypic differences in TNF response between these lines are not due to ..
  24. Schistosome Calpain as a Vaccine Candidates
    Afzal Siddiqui; Fiscal Year: 2002
    ..Our vaccine candidate is calcium activated neutral protease (= calpain, =sm-p80), which plays a pivotal role in the surface membrane renewal of schistosomes, a phenomenon which is considered to ..
  25. Role of P80 pro-IL-16 in T Cell Malignancy
    Yujun Zhang; Fiscal Year: 2008
    ..We have identified a T-cell specific protein p80 pro-IL-16, the precursor of Interleukin-16 (IL-16), as a critical negative regulator for p27 KIP1...
  26. Neurosteroids: Relevance to Cortical Development
    A Grobin; Fiscal Year: 2007
    ..These studies could represent a model of the role of neurosteroid on stress in brain development. ..
  27. LEPTIN, CYTOKINES AND INSULIN RESISTANCE
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2001
    ..The metabolic state of these animals will be characterized in detail and the role of TNF in regulating insulin action and leptin biology in vivo will be assessed in this model. ..
  28. Gene Expession in Conditioned Taste Aversion
    Louis Irwin; Fiscal Year: 2002
    ..As such, it represents a more realistic view of the way in which a system as complex as the brain likely processes and encodes experiential information. ..
  29. HYDROXYNONENAL MODIFICATION OF SUPEROXIDE DISMUTASE
    Kenneth Hensley; Fiscal Year: 2002
    ..abstract_text> ..
  30. Interaction between host cells and multicomponent material matrix
    WEIYUAN KAO; Fiscal Year: 2009
    ..e., human blood-derived macrophages, dermal fibroblasts, and keratinocytes) using monoculture and binary cell culture systems. (3) To ascertain IPN efficacy in vivo in modulating the host reaction and healing. ..
  31. CELL ADHESION IN TISSUE MORPHOGENESIS
    William Carter; Fiscal Year: 2001
    ..iii) Phosphorylation of a tyrosine residue(s) on a new membrane-associated signaling protein, p80, is the first detectable signaling event resulting from de-attachment of HFKs from laminin 5 via alpha-6-beta-4...
  32. BIOFUNCTIONAL MATERIALS CONTAINING PROTEIN MIMETICS
    WEIYUAN KAO; Fiscal Year: 2001
    ..The controlled release of these bioactive factors may have therapeutic values in the fundamental processes of inflammation, biocompatibility, and tissue healing. ..
  33. MOLECULAR BASIS OF ADIPOGENESIS
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2003
    ..Through this line of investigation, the applicant hopes to obtain novel and important information on a key biological process involving adipogenesis. ..
  34. TRANSGENIC MOUSE MODELS OF PANCREATIC EXOCRINE FUNCTION
    ROBERT DE LISLE; Fiscal Year: 2003
    ..That over expresses Muclin in the pancreatic acinar cell using the rat elastase promoter to direct cell specific expression. ..
  35. PI and Wnt Signaling in Postmortem Brain of Biopolar and Schizophrenia Subjects
    Ghanshyam N Pandey; Fiscal Year: 2011
    ..This may eventually lead to i better understanding of the pathophysiology of BP or SZ illnesses and may aid in the development of more appropriate therapeutic agents for the treatment of these disorders. ..
  36. PATHOGENEISIS OF CYSTIC FIBROSIS IN THE GI SYSTEM
    ROBERT DE LISLE; Fiscal Year: 2003
    ..Pathology and Muclin expression will be compared in CF mice, and CF mice crossed with gastrin deficient mice (lack gastric acid secretion) to normalize intestinal Ph. ..
  37. Nitric oxide and mitochondrial biogenesis in sepsis
    Claude A Piantadosi; Fiscal Year: 2010
    ..abstract_text> ..
  38. IL1 RECEPTOR ANTAGONIST INTRACELLULAR VARIANTS
    WILLIAM AREND; Fiscal Year: 2003
    ..Not only does sIL-1Ra inhibit the binding of IL-1 to cell surface receptors, but they hypothesize that the intracellular isoforms of IL-1Ra will exhibit additional antiinflammatory effect inside cells. ..
  39. Lipids, Inflammation and Insulin Action
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2008
    ..abstract_text> ..
  40. PKC and Cellular Signaling in the Suicide Brain
    Ghanshyam Pandey; Fiscal Year: 2009
    ..This knowledge may aid in developing better therapeutic strategies for the treatment of suicidal behavior. ..
  41. Host Genetic Factors in the HIV Virus Life-Cycle and HIV Disease Progression
    Jairam Lingappa; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  42. TRAINING PROGRAM IN ENVIRONMENTAL HEALTH SCIENCES
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2008
    ..abstract_text> ..
  43. Lung Injury Protection by Coagulation Blockade
    CLAUDE PIANTADOSI; Fiscal Year: 2008
    ..A successfully optimized strategy could greatly attenuate persistence of pulmonary inflammation and facilitate the resolution of human ARDS. ..
  44. 2008 Biology of Acute Respiratory Infections Gordon Research Conference
    JOSEPH MIZGERD; Fiscal Year: 2007
    ..End of Abstract) [unreadable] [unreadable] [unreadable]..
  45. BIOFUNCTIONAL MATERIALS CONTAINING PROTEIN MIMETICS
    WEIYUAN KAO; Fiscal Year: 2007
    ....
  46. Immunobiology of Dendritic Cells in Crohn's Disease
    LESLEY SMYTHIES; Fiscal Year: 2006
    ..2. Determine whether the reduced level of maturity and activation of DCs from normal intestinal mucosa compared to DCs from Crohn's disease mucosa is due to the effects of intestinal stromal factors on DCs. ..
  47. VENTILATOR-ASSOCIATED ALVEOLAR EPITHELIAL INJURY
    James Frank; Fiscal Year: 2006
    ..This research and comprehensive career development plan will prepare me to become an independent investigator in the mechanisms of alveolar epithelial injury and ventilator-associated lung injury. ..
  48. Melanocortins, Energy Balance and Cancer Anorexia
    Brent Wisse; Fiscal Year: 2006
    ..Schwartz and the Harborview Medical Center Energy Metabolism Laboratory, and by joining a large community of productive researchers in the field of energy homeostasis across the University of Washington campus. ..
  49. BIOFUNCTIONAL MATERIALS CONTAINING PROTEIN MIMETICS
    WEIYUAN KAO; Fiscal Year: 2003
    ..The controlled release of these bioactive factors may have therapeutic values in the fundamental processes of inflammation, biocompatibility, and tissue healing. ..
  50. Communication Between Laminin 5 and Gap Junctions
    William Carter; Fiscal Year: 2005
    ..These studies will provide an understanding of components and mechanisms critical for regulating epithelial morphogenesis in development, wound repair and tumor invasion. ..
  51. Molecular determinants of exercise-induced muscle damage
    Monica Hubal; Fiscal Year: 2004
    ..Understanding these processes could lead to novel treatments for musculodystrophy and other myopathies that are characterized by muscle degradation. ..
  52. FRZB PROFILES AS OSTEOARTHRITIS BIOMARKERS
    MARY CORR; Fiscal Year: 2004
    ..The results of these studies will both contribute to, and will utilize, the resources of the OA biomarker consortium. ..
  53. Lysine decarboxylase in periodontitis patients
    Martin Levine; Fiscal Year: 2004
    ..abstract_text> ..