Gene Symbol: IL1A
Description: interleukin 1 alpha
Alias: IL-1A, IL1, IL1-ALPHA, IL1F1, IL-1 alpha, hematopoietin-1, interleukin 1, alpha, preinterleukin 1 alpha, pro-interleukin-1-alpha
Species: human

Top Publications

  1. ncbi Interleukin 1B gene polymorphism is associated with baseline C-reactive protein levels in healthy individuals
    Carita Eklund
    Department of Microbiology and Immunology, University of Tampere Medical School, Tampere, Finland
    Eur Cytokine Netw 14:168-71. 2003
  2. doi Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis
    M Bryant Howren
    Department of Psychology, The University of Iowa, 11 Seashore Hall East, Iowa City, IA 52242, USA
    Psychosom Med 71:171-86. 2009
  3. doi Mycobacterium tuberculosis induces IL-17A responses through TLR4 and dectin-1 and is critically dependent on endogenous IL-1
    Frank L van de Veerdonk
    Department of Medicine, Radboud University Nijmegen Medical Center, Geert Grooteplein Zuid 8, 6525 GA Nijmegen, The Netherlands
    J Leukoc Biol 88:227-32. 2010
  4. pmc Ovarian cancer risk associated with inherited inflammation-related variants
    Kristin L White
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Cancer Res 72:1064-9. 2012
  5. doi Association between interleukin 1 gene cluster polymorphisms and bilateral distal interphalangeal osteoarthritis
    Svetlana Solovieva
    Centre of Expertise Health and Work Ability, Finnish Institute of Occupational Health, Helsinki, Finland
    J Rheumatol 36:1977-86. 2009
  6. ncbi Interleukins-1, -4, -6, -10, tumor necrosis factor, transforming growth factor-beta, FAS, and mannose-binding protein C gene polymorphisms in Australian women: Risk of preterm birth
    Margaret F Annells
    Department of Microbiology and Infectious Diseases, Women s and Children s Hospital, North Adelaide, South Australia
    Am J Obstet Gynecol 191:2056-67. 2004
  7. pmc Binding of human immunodeficiency virus type 1 to CD4 and CXCR4 receptors differentially regulates expression of inflammatory genes and activates the MEK/ERK signaling pathway
    W Popik
    Oncology Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    J Virol 72:6406-13. 1998
  8. ncbi Lipopolysaccharide-mediated reactive oxygen species and signal transduction in the regulation of interleukin-1 gene expression
    Hsien Yeh Hsu
    Faculty of Medical Technology, Institute of Biotechnology in Medicine, National Yang Ming University, 112 Taipei, Taiwan
    J Biol Chem 277:22131-9. 2002
  9. doi Proinflammatory cytokine polymorphisms and the risk of preterm birth and low birthweight in a Japanese population
    F Sata
    Department of Public Health, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Mol Hum Reprod 15:121-30. 2009
  10. pmc Genetic variants in IL1A and IL1B contribute to the susceptibility to 2009 pandemic H1N1 influenza A virus
    Yingxia Liu
    Guangdong Key Laboratory for Emerging Infectious Diseases, Shenzhen Third People s Hospital, Guangdong Medical College, Shenzhen, China
    BMC Immunol 14:37. 2013

Detail Information

Publications259 found, 100 shown here

  1. ncbi Interleukin 1B gene polymorphism is associated with baseline C-reactive protein levels in healthy individuals
    Carita Eklund
    Department of Microbiology and Immunology, University of Tampere Medical School, Tampere, Finland
    Eur Cytokine Netw 14:168-71. 2003
    ..a study of 338 healthy blood donors whose CRP levels were determined and whose single nucleotide polymorphisms of IL1A(C/T)-889, IL1B(C/T)-511, IL1B(C/T) + 3954, IL6(G/C)-174 and ILRN (a VNTR) both genotyped and haplotyped...
  2. doi Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis
    M Bryant Howren
    Department of Psychology, The University of Iowa, 11 Seashore Hall East, Iowa City, IA 52242, USA
    Psychosom Med 71:171-86. 2009
    ..To assess the magnitude and direction of associations of depression with C-reactive protein (CRP), interleukin (IL)-1, and IL-6 in community and clinical samples...
  3. doi Mycobacterium tuberculosis induces IL-17A responses through TLR4 and dectin-1 and is critically dependent on endogenous IL-1
    Frank L van de Veerdonk
    Department of Medicine, Radboud University Nijmegen Medical Center, Geert Grooteplein Zuid 8, 6525 GA Nijmegen, The Netherlands
    J Leukoc Biol 88:227-32. 2010
    ..These findings contribute to a better understanding of the host response to mycobacteria and provide the opportunity to explore potential, novel, therapeutic strategies against TB...
  4. pmc Ovarian cancer risk associated with inherited inflammation-related variants
    Kristin L White
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Cancer Res 72:1064-9. 2012
    ..Combined analysis revealed association with SNPs rs17561 and rs4848300 in the interleukin gene IL1A which varied by histologic subtype (P(heterogeneity) = 0.03)...
  5. doi Association between interleukin 1 gene cluster polymorphisms and bilateral distal interphalangeal osteoarthritis
    Svetlana Solovieva
    Centre of Expertise Health and Work Ability, Finnish Institute of Occupational Health, Helsinki, Finland
    J Rheumatol 36:1977-86. 2009
    To examine the association of the interleukin 1 gene (IL1) cluster polymorphisms and their haplotypes with bilateral distal interphalangeal joint osteoarthritis (DIP OA).
  6. ncbi Interleukins-1, -4, -6, -10, tumor necrosis factor, transforming growth factor-beta, FAS, and mannose-binding protein C gene polymorphisms in Australian women: Risk of preterm birth
    Margaret F Annells
    Department of Microbiology and Infectious Diseases, Women s and Children s Hospital, North Adelaide, South Australia
    Am J Obstet Gynecol 191:2056-67. 2004
    ..The purpose of this study was to examine the relationship between preterm birth and 22 single nucleotide polymorphisms in genes that encode cytokines and mediators of apoptosis and host defense...
  7. pmc Binding of human immunodeficiency virus type 1 to CD4 and CXCR4 receptors differentially regulates expression of inflammatory genes and activates the MEK/ERK signaling pathway
    W Popik
    Oncology Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    J Virol 72:6406-13. 1998
  8. ncbi Lipopolysaccharide-mediated reactive oxygen species and signal transduction in the regulation of interleukin-1 gene expression
    Hsien Yeh Hsu
    Faculty of Medical Technology, Institute of Biotechnology in Medicine, National Yang Ming University, 112 Taipei, Taiwan
    J Biol Chem 277:22131-9. 2002
  9. doi Proinflammatory cytokine polymorphisms and the risk of preterm birth and low birthweight in a Japanese population
    F Sata
    Department of Public Health, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Mol Hum Reprod 15:121-30. 2009
    ..Genotyping of IL1A -889C/T, +4845G/T (A114S), IL1B -511C/T, -31C/T, IL2 -384T/G and IL6 -634C/G polymorphisms was determined by an ..
  10. pmc Genetic variants in IL1A and IL1B contribute to the susceptibility to 2009 pandemic H1N1 influenza A virus
    Yingxia Liu
    Guangdong Key Laboratory for Emerging Infectious Diseases, Shenzhen Third People s Hospital, Guangdong Medical College, Shenzhen, China
    BMC Immunol 14:37. 2013
    ..Four SNPs (rs1304037, rs16347, rs17561, rs2071373) in IL1A gene and three SNPs (rs1143623, rs3917345, rs1143627) in IL1B gene were genotyped by using matrix-assisted laser ..
  11. doi Interleukin-1 gene cluster and IL-1 receptor polymorphisms in Iranian patients with systemic lupus erythematosus
    Zahra Tahmasebi
    Rheumatology Research Center, Shariati Hospital, Tehran University of Medical Sciences, Kargar Ave, PO BOX 1411713137, Tehran, Iran
    Rheumatol Int 33:2591-6. 2013
    ..Variation at this locus may affect IL-1 receptor antagonist activity, supporting the hypothesis that altered or imbalanced IL1 production may affect the risk of developing SLE.
  12. doi Allele, genotype, and composite genotype effects of IL-1A +4845 and IL-1B +3954 polymorphisms for chronic periodontitis in an Indian population
    R Gayathri
    Department of Periodontics, Manipal Life Sciences Centre, Manipal University, Manipal, Karnataka, India
    Indian J Dent Res 22:612. 2011
    ..A case control study was performed to determine the role of IL-1A+4845 and IL-1B+3954 polymorphisms in the predisposition to chronic periodontitis...
  13. doi Active caspase-1 is a regulator of unconventional protein secretion
    Martin Keller
    Institute of Cell Biology, Department of Biology, ETH Zurich, CH 8093 Zurich, Switzerland
    Cell 132:818-31. 2008
    ..By this mechanism, stress-induced activation of caspase-1 directly links inflammation to cytoprotection, cell survival, and regenerative processes...
  14. pmc Regulation of epithelial-mesenchymal IL-1 signaling by PPARbeta/delta is essential for skin homeostasis and wound healing
    Han Chung Chong
    School of Biological Sciences, Nanyang Technological University, Singapore 637551
    J Cell Biol 184:817-31. 2009
    ..Given the ubiquitous expression of PPARbeta/delta, other epithelial-mesenchymal interactions may also be regulated in a similar manner...
  15. pmc Circulating levels of interleukin-1 family cytokines in overweight adolescents
    Christian Jung
    Department of Internal Medicine I, Friedrich Schiller University, Erlanger Allee 101, 07747 Jena, Germany
    Mediators Inflamm 2010:958403. 2010
    ..Obesity and related diseases are dramatically increasing problems, particularly in children and adolescents. We determined circulating levels of different interleukin (IL)-1 family members in normal weight and overweight adolescents...
  16. doi Graves' ophthalmopathy and gene polymorphisms in interleukin-1alpha, interleukin-1beta, interleukin-1 receptor and interleukin-1 receptor antagonist
    Omid Khalilzadeh
    Endocrinology and Metabolism Research Center, Vali Asr Hospital, Tehran, Iran
    Clin Experiment Ophthalmol 37:614-9. 2009
    ..This study aimed to investigate the association of GO with single-nucleotide polymorphisms (SNPs) in the IL-1 family (IL-1alpha, IL-1beta, IL-1 receptor [IL-1R] and IL-1 receptor antagonist [IL-1RA])...
  17. ncbi Interaction between poly(ADP-ribose) polymerase 1 and interleukin 1A genes is associated with Alzheimer's disease risk
    Jon Infante
    Neurology Service, Marques de Valdecilla University Hospital, University of Cantabria, Santander, Spain
    Dement Geriatr Cogn Disord 23:215-8. 2007
    ..PARP-1 -410 and PARP-1 -1672 haplotypes were associated with an increased risk for AD (global haplotype association p value=0.019), and, in addition, PARP-1 haplotypes increased the risk of AD by interaction with the IL-1A -889 allele 2...
  18. ncbi Transcriptional responses of human epidermal keratinocytes to cytokine interleukin-1
    Shoichiro Yano
    Department of Dermatology, NYU School of Medicine, New York 10016, USA
    J Cell Physiol 214:1-13. 2008
    ..In summary, IL-1 regulates a characteristic set of genes that define its specific contribution to inflammation and aberrant differentiation in skin diseases...
  19. ncbi Membrane-associated IL-1 contributes to chronic synovitis and cartilage destruction in human IL-1 alpha transgenic mice
    Yasuo Niki
    Department of Orthopedic Surgery, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Immunol 172:577-84. 2004
    ..These results suggest that MA-IL-1 contributes to synoviocyte self-proliferation and subsequent cartilage destruction in inflammatory joint disease such as rheumatoid arthritis...
  20. pmc Modic changes and interleukin 1 gene locus polymorphisms in occupational cohort of middle-aged men
    Jaro Karppinen
    Finnish Institute of Occupational Health, Helsinki, Finland
    Eur Spine J 18:1963-70. 2009
    ..However, their pathophysiology remains largely unknown. A previous study of Northern Finnish males implicated that IL1A and MMP3 polymorphisms play a role in type II Modic changes...
  21. ncbi Mass spectrometric analysis of the endogenous type I interleukin-1 (IL-1) receptor signaling complex formed after IL-1 binding identifies IL-1RAcP, MyD88, and IRAK-4 as the stable components
    Constantinos Brikos
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, London, UK
    Mol Cell Proteomics 6:1551-9. 2007
    ..The only component of the IL-1RI signaling complex that dissociated is IRAK-1. Our study is therefore the first detailed description of the endogenous IL-1RI complex...
  22. doi Ectopic expression of interleukin-1 receptor type II enhances cell migration through activation of the pre-interleukin 1alpha pathway
    Shih Yu Chang
    Institute of Biopharmaceutical Sciences, National Yang Ming University, Taipei, Taiwan, ROC
    Cytokine 45:32-8. 2009
    ..Because SIP-1 is a repressor of COL1A1-induced E-cadherin expression, the present results suggest that IL1R2 overexpression is likely through activation of the pIL-1alpha pathway to enhance cell migration...
  23. doi An insertion/deletion polymorphism at miRNA-122-binding site in the interleukin-1alpha 3' untranslated region confers risk for hepatocellular carcinoma
    Yuzhen Gao
    Laboratory of Cellular and Molecular Tumor Immunology, Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, Medical College, Soochow University, Suzhou 215123, Jiangsu, People s Repubic of China
    Carcinogenesis 30:2064-9. 2009
    ..We selected an insertion/deletion (Indel) polymorphism (rs3783553) in the 3' UTR of interleukin (IL)-1alpha (IL1A) for a case-control study in a Chinese population...
  24. doi Convergent evidence shows a positive association of interleukin-1 gene complex locus with susceptibility to schizophrenia in the Caucasian population
    Mingqing Xu
    School of Public Health, Harvard University, Boston, MA 02115, USA
    Schizophr Res 120:131-42. 2010
    Recent genetic studies have revealed that the Interleukin-1 (IL1) gene complex (IL1 alpha, IL1 beta and IL1 receptor antagonist) is associated with schizophrenia, but contradictory findings have also been reported...
  25. ncbi Candidate-gene association study of mothers with pre-eclampsia, and their infants, analyzing 775 SNPs in 190 genes
    Katrina A B Goddard
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA
    Hum Hered 63:1-16. 2007
    ..The most significant findings for association with PE were COL1A1 (p = 0.0011) and IL1A (p = 0.0014) for the maternal genotype, and PLAUR (p = 0.0008) for the offspring genotype...
  26. doi A nonsynonymous variant of IL1A is associated with endometriosis in Japanese population
    Yuki Hata
    Department of Obstetrics and Gynecology, Niigata University Graduate School of Medicine and Dental Sciences, Niigata, Japan
    J Hum Genet 58:517-20. 2013 has demonstrated that single-nucleotide polymorphisms (SNPs) located in intronic and downstream regions of IL1A (interleukin 1α) were associated with the risk of endometriosis...
  27. pmc The precursor form of IL-1alpha is an intracrine proinflammatory activator of transcription
    Ariel Werman
    Department of Microbiology and Immunology, Faculty of Health Sciences and Cancer Research Center, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Proc Natl Acad Sci U S A 101:2434-9. 2004
    ..Because this mechanism of action is not affected by extracellular inhibitors, reducing intracellular functions of IL-1alpha might prove beneficial in some inflammatory conditions...
  28. doi Interleukin-1α -899 (+4845) C→T polymorphism increases the risk of chronic periodontitis: evidence from a meta-analysis of 23 case-control studies
    Min Mao
    Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, PR China
    Gene 532:114-9. 2013
    ..CT+CC). Stratified analyses revealed that there was a significantly increased risk for Caucasians and Asians. In conclusion, current evidence showed that IL-1α -899 (+4845) C→T polymorphism probably increased the risk of CP. ..
  29. ncbi A critical assessment of interleukin-1 (IL-1) genotyping when used in a genetic susceptibility test for severe chronic periodontitis
    Gary Greenstein
    University of Medicine and Dentistry of New Jersey, Newark, USA
    J Periodontol 73:231-47. 2002
  30. pmc Systemic lupus erythematosus and genetic variation in the interleukin 1 gene cluster: a population based study in the southeastern United States
    C G Parks
    National Institute of Environmental Health Sciences, NIH, DHHS, Durham, NC, USA
    Ann Rheum Dis 63:91-4. 2004
    Interleukin (IL)1alpha and IL1beta, and their endogenous receptor antagonist (IL1Ra), have been related to the pathology of systemic lupus erythematosus (SLE), but the role of IL1 polymorphisms in the aetiology of SLE is unknown.
  31. pmc N-myc downstream-regulated gene 1 promotes tumor inflammatory angiogenesis through JNK activation and autocrine loop of interleukin-1α by human gastric cancer cells
    Yuichi Murakami
    Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    J Biol Chem 288:25025-37. 2013
    ..Together, activation of JNK/AP-1 thus seems to promote tumor angiogenesis in relationship to NDRG1-induced inflammatory stimuli by gastric cancer cells. ..
  32. doi Vascular smooth muscle cell apoptosis induces interleukin-1-directed inflammation: effects of hyperlipidemia-mediated inhibition of phagocytosis
    Murray C H Clarke
    Division of Cardiovascular Medicine, University of Cambridge, Box 110, ACCI, Addenbrooke s Hospital, Cambridge, CB2 2QQ, UK
    Circ Res 106:363-72. 2010
  33. ncbi Salivary enzyme levels after scaling and interleukin-1 genotypes in Japanese patients with chronic periodontitis
    Hiromasa Yoshie
    Department of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Periodontol 78:498-503. 2007
  34. doi Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus
    E Y M G Fung
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
    Genes Immun 10:188-91. 2009
    ..70 x 10(-3) to 3.20 x 10(-5). These findings extend our knowledge of susceptibility locus sharing across different autoimmune diseases, and provide convincing evidence that the RA/SLE locus 6q23/TNFAIP3 is a newly identified T1D locus...
  35. doi Complex effects of IL1A polymorphism and calpain inhibitors on interleukin 1 alpha (IL-1 alpha) mRNA levels and secretion of IL-1 alpha protein
    S Lee
    Department of Clinical Immunology and Immunogenetics, Royal Perth Hospital, University of Western Australia, Perth, Australia
    Tissue Antigens 72:67-71. 2008
    Alleles of IL1A-889(C>T) and IL1A+4845(G>T) are in linkage disequilibrium. Interleukin 1alpha (IL-1alpha) is produced as a precursor protein and cleaved at positions 117-118 by calpain, generating a mature protein for export...
  36. doi Interleukin-1 cluster gene polymorphisms in childhood IgA nephropathy
    Won Ho Hahn
    Department of Pediatrics, East West Kidney Diseases Research Institute, School of Medicine, Kyung Hee University, Dondaemun gu, Hoegi dong 1, Seoul, 130 701, Korea
    Pediatr Nephrol 24:1329-36. 2009
    ..SNPs of the IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist (RN) genes (IL1A, IL1B, and IL1RN, respectively) were analyzed in 182 patients with childhood IgAN and in 500 healthy controls...
  37. ncbi Interleukin 1 gene cluster, myocardial infarction at young age and inflammatory response of human mononuclear cells
    Maria Carmela Latella
    John Paul II Center for High Technology Research and Education in Biomedical Sciences, Catholic University, Campobasso, Italy
    Immunol Invest 38:203-19. 2009
    ..No association was found between block "B" IL-1B haplotypes or IL-1A and IL-RA polymorphisms and risk of MI. IL-1B haplotypes influence the inflammatory response of human mononuclear cells to LPS and affect the risk of MI at young age...
  38. ncbi Interleukin-1 gene cluster polymorphisms and alcoholism in Spanish men
    Isabel J Pastor
    Unidad de Medicina Molecular, Departamento de Medicina, Salamanca, Spain
    Alcohol Alcohol 40:181-6. 2005
    ..We analysed the distribution of single nucleotide polymorphisms (SNPs) located in the IL1A, IL1B, IL1R1 and IL1RN genes in alcoholic and non-alcoholic Spanish subjects.
  39. pmc Modulatory effect of interleukin-1α on expression of structural matrix proteins, MMPs and TIMPs in human cardiac myofibroblasts: role of p38 MAP kinase
    Neil A Turner
    Division of Cardiovascular and Neuronal Remodelling, Leeds Institute of Genetics, Health and Therapeutics LIGHT, University of Leeds, Leeds, UK
    Matrix Biol 29:613-20. 2010
    ..In summary, IL-1α induces a distinct pattern of ECM protein and protease expression in human CMF, in part regulated by distinct p38 MAPK subtypes, affirming the key role of IL-1α and CMF in post-infarction cardiac remodeling...
  40. ncbi Functional correlates of the interleukin-1 receptor antagonist gene polymorphism in the colonic mucosa in ulcerative colitis
    M J Carter
    The Gastroenterology and Liver Unit, University of Sheffield, Royal Hallamshire Hospital, Sheffield, UK
    Genes Immun 5:8-15. 2004
    ..IL1RN, IL1A and IL1B genotypes were determined using restriction-enzyme analysis...
  41. pmc Human immunodeficiency virus type 1 gp120 induces anergy in human peripheral blood lymphocytes by inducing interleukin-10 production
    D Schols
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium
    J Virol 70:4953-60. 1996
  42. doi Polymorphisms of the IL-1 gene complex are associated with alcohol dependence in Spanish Caucasians: data from an association study
    Pilar A Saiz
    Department of Psychiatry, School of Medicine, Centro de Investigación Biomédica en Red de Salud Mental, University of Oviedo, Julian Claveria 6 3, Oviedo, Spain
    Alcohol Clin Exp Res 33:2147-53. 2009
  43. ncbi The interrelated role of fibronectin and interleukin-1 in biomaterial-modulated macrophage function
    David Richard Schmidt
    School of Pharmacy, University of Wisconsin Madison, 777 Highland Ave, Madison, WI 53705, USA
    Biomaterials 28:371-82. 2007
    ..This literature review presents a comprehensive survey of past and current research on the interrelated role of IL-1, FN, and FN-derivatives in determining biomaterial-modulated macrophage function...
  44. ncbi Interleukin-1, interleukin-10 and tumour necrosis factor-alpha gene polymorphisms in hepatitis C virus infection: an investigation of the relationships with spontaneous viral clearance and response to alpha-interferon therapy
    Patricia K Constantini
    Institute of Liver Studies, King s College Hospital, London SE5 9RS, UK
    Liver 22:404-12. 2002
    ..The aim of this study was to investigate the relationship between a number of these candidate genes and both spontaneous and treatment related clearance of hepatitis C virus infection...
  45. ncbi [Association between interleukin-1 alpha-889 C/T polymorphism and Alzheimer's disease in Chinese Han population]
    Yong tao Zhou
    Department of Neurology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 28:186-90. 2006
    ..To explore the possible association between interleukin-1 alpha-889C/T (IL-1 alpha-889 C/T) polymorphism and Alzheimer's disease (AD) in Chinese Han population...
  46. ncbi Interleukin 1alpha, interleukin 1beta and interleukin 1 receptor gene polymorphisms in psoriatic arthritis
    J S Ravindran
    Royal National Hospital for Rheumatic Diseases, Bath, UK
    Rheumatology (Oxford) 43:22-6. 2004
    ..To investigate polymorphisms of interleukin (IL) 1alpha, IL-1beta and IL-1 receptor R1 genes in patients with psoriatic arthritis (PsA), their relationship to the age of onset of psoriasis and the pattern of joint involvement...
  47. pmc Association of IL-1 RN*2 allele and methionine synthase 2756 AA genotype with dementia severity of sporadic Alzheimer's disease
    P Bosco
    IRCCS Associazione Oasi Maria SS, Institute for Research on Mental Retardation and Brain Aging, Troina, Italy
    J Neurol Neurosurg Psychiatry 75:1036-8. 2004
    ..Genetic polymorphisms of APO-E, homocysteine, and the IL-1 gene cluster (IL-1A, IL-1B, receptor antagonist IL-1RN) are associated with sporadic Alzheimer's disease and may involve interdependent pathways of neuronal toxicity...
  48. ncbi SHP-2 modulates interleukin-1-induced Ca2+ flux and ERK activation via phosphorylation of phospholipase Cgamma1
    Qin Wang
    Canadian Institutes of Health Research Group in Matrix Dynamics, University of Toronto, Toronto, Ontario M5S 3E8
    J Biol Chem 280:8397-406. 2005
    ..Focal adhesions co-localizing with the endoplasmic reticulum may provide molecular staging sites required for ERK activation...
  49. ncbi Lack of association between the interleukin-1 gene complex and schizophrenia in a Japanese population
    Yuichiro Watanabe
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Psychiatry Clin Neurosci 61:364-9. 2007
    Interleukin-1 (IL1) is an inflammatory cytokine and exerts neurodegenerative effects in the brain. Several studies have indicated that IL1 is likely to be involved in the pathogenesis of schizophrenia...
  50. ncbi Interleukin-1 and tumor necrosis factor-alpha gene polymorphisms in Turkish patients with localized aggressive periodontitis
    Esra Guzeldemir
    Department of Periodontology, Faculty of Dentistry, Baskent University, Ankara, Turkey
    J Oral Sci 50:151-9. 2008
    ..Moreover, IL-1 gene polymorphisms appear to have a role in susceptibility to LAgP, and the above-mentioned genotypes could be an important risk factor for LAgP in the Turkish population...
  51. doi Investigation of the interleukin-1 gene cluster polymorphisms in Jordanian patients with chronic and aggressive periodontitis
    Jumana A Karasneh
    Department of Oral Medicine and Oral Surgery, Dental School, Jordan University of Science and Technology, Irbid, Jordan
    Arch Oral Biol 56:269-76. 2011
    ..IL-1 gene polymorphisms have been associated with the IL-1 level. The aim of this study was to investigate if IL-1 gene cluster polymorphisms are associated with chronic (CP) and aggressive (AgP) periodontitis in a Jordanian population...
  52. doi The role of interleukin-1 in wound biology. Part II: In vivo and human translational studies
    Yajing Hu
    Department of Anesthesia, Stanford University, Stanford, USA
    Anesth Analg 111:1534-42. 2010
    ..We further investigate the role of IL-1 in incisional wound biology and its effect on wound chemokine production in vivo and whether this mechanism could be active in human subjects...
  53. doi Interleukin-1 promoter region polymorphism role in rheumatoid arthritis: a meta-analysis of IL-1B-511A/G variant reveals association with rheumatoid arthritis
    P Harrison
    Botnar Research Centre, Nuffield Orthopaedic Centre, Windmill Road, Oxford OX3 7LD, UK
    Rheumatology (Oxford) 47:1768-70. 2008
    ..This study examined the effects of four common promoter SNPs in the IL-1 region on susceptibility and clinical characteristics of RA in British Caucasian patients and assessed the risk of RA by meta-analysis of published studies...
  54. doi IL-1 gene cluster is not linked to aggressive periodontitis
    C Scapoli
    Department of Biology and Evolution, University of Ferrara, Corso Ercole I d Este 32, I 44100 Ferrara, Italy
    J Dent Res 89:457-61. 2010
    ..No association between AgP and IL1A, IL1B, and IL1RN genes was found in either single-point or haplotype analyses...
  55. doi IL-1-dependent, IL-1R1-independent resistance to gastrointestinal nematodes
    Neil E Humphreys
    Faculty of Life Sciences, The University of Manchester, Manchester, UK
    Eur J Immunol 39:1036-45. 2009
  56. doi Interleukin-1 region meta-analysis with osteoarthritis phenotypes
    G Moxley
    Virginia Commonwealth University, Richmond, VA 23298 0263, USA
    Osteoarthritis Cartilage 18:200-7. 2010
    ..Several research groups have examined osteoarthritis (OA) association with Interleukin-1 (IL-1) region markers and haplotypes. The results have been suggestive for hand OA, negative for knee OA, and conflicting for hip OA...
  57. pmc Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations
    Mukundan Attur
    Division of Rheumatology, New York University Hospital for Joint Diseases, New York, NY 10003, USA
    Ann Rheum Dis 69:856-61. 2010
    ..A lack of biomarkers that identify patients at risk for severe osteoarthritis (OA) complicates development of disease-modifying OA drugs...
  58. ncbi Induction of interleukin-1 and glucocorticoid hormones by HIV promotes viral replication and links human chromosome 2 to AIDS pathogenesis: genetic mechanisms and therapeutic implications
    P A Corley
    Med Hypotheses 48:415-21. 1997
    ..IL-1 also adversely affects acquired immune deficiency syndrome-related Kaposi's sarcoma. Several genetic treatments for human immunodeficiency virus infection are proposed...
  59. ncbi IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp
    G Pan
    Department of Endocrinology, Genentech, Inc, 1 DNA Way, South San Francisco, CA, 94080, USA
    Cytokine 13:1-7. 2001
    ..These findings suggest that IL-1H may be another ligand for the IL-18 receptor and a new player in the inflammatory and immune responses mediated by the IL-18/IL-18R axis...
  60. doi Cytokine IL-1 beta but not IL-1 alpha promoter polymorphism is associated with Alzheimer disease in a population from the Canary Islands, Spain
    M C Déniz-Naranjo
    Department of Immunology, Hospital Universitario Dr Negrín de Gran Canaria, Las Palmas de Gran Canaria, Spain
    Eur J Neurol 15:1080-4. 2008
    ..Based on these data, our work attempts to investigate the effects of some promoter polymorphisms of pro-inflammatory cytokines [interleukin (IL)-1 alpha and IL-1 beta] on AD...
  61. pmc Interleukin 1α sustains the expression of inflammatory factors in human pancreatic cancer microenvironment by targeting cancer-associated fibroblasts
    Vegard Tjomsland
    Division of Molecular Virology, Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden
    Neoplasia 13:664-75. 2011
    ..e. CAFs, is one essential factor in the formation of the inflammatory tumor environment, and we propose that neutralization of the IL-1α signaling might be a potential therapy for this cancer...
  62. ncbi Association of tumor necrosis factor-alpha and interleukin-1 gene polymorphisms with silicosis
    B Yucesoy
    Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, West Virginia 26505, USA
    Toxicol Appl Pharmacol 172:75-82. 2001
    ..These studies suggest that gene-environment interactions involving cytokine polymorphisms play a significant role in silicosis by modifying the extent of and susceptibility to disease...
  63. ncbi Regulation of IL-1 family cytokines IL-1alpha, IL-1 receptor antagonist, and IL-18 by 1,25-dihydroxyvitamin D3 in primary keratinocytes
    Juan Kong
    Department of Medicine, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    J Immunol 176:3780-7. 2006
    ..Collectively, these results suggest that vitamin D modulates cutaneous inflammatory reactions, at least in part, by increasing the IL-1Ra to IL-1alpha ratio and suppressing IL-18 synthesis in keratinocytes...
  64. doi Association of PDE4D and IL-1 gene polymorphism with ischemic stroke in a Han Chinese population
    Nan Li
    Department of Neurology, The First Affiliated Hospital of China Medical University, Shenyang 110001, China
    Brain Res Bull 81:38-42. 2010
    ..However, little is known about whether this association could also occur in Han Chinese...
  65. pmc Intracellular interleukin-1alpha mediates interleukin-8 production induced by Chlamydia trachomatis infection via a mechanism independent of type I interleukin-1 receptor
    Wen Cheng
    Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Infect Immun 76:942-51. 2008
    ..Thus, we have identified a novel mechanism for chlamydial induction of the chemokine IL-8...
  66. ncbi Interleukin-1 gene cluster polymorphisms in sarcoidosis and idiopathic pulmonary fibrosis
    Beata Hutyrova
    Departments of Immunology, Biology, and Respiratory Medicine, Palacky University, Olomouc, Czech Republic
    Am J Respir Crit Care Med 165:148-51. 2002
    ..Further population studies are warranted to confirm the observed association between sarcoidosis and the IL-1alpha polymorphism and also to explore mechanisms of IL-1alpha -889 participation in aberrant immune response in sarcoidosis...
  67. ncbi Association between the interleukin-1alpha gene and Alzheimer's disease: a meta-analysis
    I Rainero
    Neurology III Headache Center, Department of Neuroscience, University of Turin, Via Cherasco, 15 10126 Torino, Italy
    Neurobiol Aging 25:1293-8. 2004
    ..Analysis of subgroups showed a significant association in patients with early-onset AD but not in late-onset AD. Our data support a significant but modest association between the T/T genotype of the IL-1alpha gene and AD...
  68. pmc Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network
    Arturo V Orjalo
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Proc Natl Acad Sci U S A 106:17031-6. 2009
    ..Thus, cell surface IL-1alpha is an essential cell-autonomous regulator of the senescence-associated IL-6/IL-8 cytokine network...
  69. ncbi The balance between IL-1 and IL-1Ra in disease
    William P Arend
    B115 Division of Rheumatology, Health Sciences Centre, University of Colorado, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Cytokine Growth Factor Rev 13:323-40. 2002
    ..Treatment of RA with daily subcutaneous injections of recombinant IL-1Ra protein has been shown to be efficacious. Gene therapy approaches with IL-1Ra are being evaluated for the treatment of RA and other human diseases...
  70. ncbi Intracellular interleukin-1alpha functionally interacts with histone acetyltransferase complexes
    Miroslava Buryskova
    Department of Pharmacology of Natural Products and Clinical Pharmacology, University of Ulm, D 89081 Ulm, Germany
    J Biol Chem 279:4017-26. 2004
    ..Our data provide the first solid evidence for the nuclear target of the IL-1alpha precursor and suggest its novel function in transcriptional control...
  71. ncbi Proinflammatory cytokine single nucleotide polymorphisms in nasal polyposis
    Selim S Erbek
    Department of Otolaryngology, Faculty of Medicine, Baskent University Konya Teaching and Research Center, Saray Caddesi No 1, Selcuklu Konya, Ankara, Turkey
    Arch Otolaryngol Head Neck Surg 133:705-9. 2007
    ..the association between nasal polyposis (NP) and single nucleotide polymorphisms of the proinflammatory cytokines IL (interleukin) 1alpha (the IL1A gene), IL-1beta (the IL1B gene), and tumor necrosis factor alpha (the TNFA gene).
  72. pmc Identification of the cellular sensor that stimulates the inflammatory response to sterile cell death
    Hajime Kono
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 184:4470-8. 2010
    ..One key way they accomplish this important task is by producing IL-1alpha that is needed to initiate the inflammatory response...
  73. pmc Intracellular IL-1alpha-binding proteins contribute to biological functions of endogenous IL-1alpha in systemic sclerosis fibroblasts
    Yasushi Kawaguchi
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo 162 0054, Japan
    Proc Natl Acad Sci U S A 103:14501-6. 2006
    ..These findings reveal that nuclear localization of pre-IL-1alpha depends on the binding to HAX-1 and that biological activities might be elicited by the binding to both HAX-1 and IL-1RII in SSc fibroblasts...
  74. ncbi Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs
    C J March
    Nature 315:641-7. 1985
    ..The primary translation products of the genes are 271 and 269 amino acids long, although expression in Escherichia coli of the carboxy-terminal 159 and 153 amino acids produces IL-1 biological activity...
  75. ncbi Ethnic-specific genetic associations with pulmonary tuberculosis
    Julio C Delgado
    Center for Blood Research and Departments of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Infect Dis 186:1463-8. 2002
  76. ncbi Genetic variation in pro-inflammatory cytokines (interleukin-1beta, interleukin-1alpha and interleukin-6) associated with the aggressive forms, survival, and relapse prediction of breast carcinoma
    Kaouther Snoussi
    Laboratoire d Immuno Oncologie Moleculaire, Faculte de medecine de Monastir, Universite de Monastir, 5019 Monastir, Tunisia
    Eur Cytokine Netw 16:253-60. 2005
    ..We designed a broad study to investigate the susceptibility and prognostic implications of the genetic variation in IL-1alpha, IL-1beta and IL-6 in breast carcinoma...
  77. ncbi Potential influence of IL1B haplotype and IL1A-IL1B-IL1RN extended haplotype on hand osteoarthritis risk
    G Moxley
    Virginia Commonwealth University, Richmond, VA, USA
    Osteoarthritis Cartilage 15:1106-12. 2007
    ..To assess osteoarthritis (OA) association with the human interleukin-1 (IL-1) region...
  78. ncbi Relations between interleukin-1, its receptor antagonist gene polymorphism, and bone mineral density in postmenopausal Korean women
    Jung Gu Kim
    Department of Obstetrics and Gynecology, College of Medicine, Seoul National University Hospital, 28 Yeunkeun dong, Chongno Gu, Seoul 110 744, Korea
    J Bone Miner Metab 24:53-7. 2006
    ..These data suggest that IL-1ra gene VNTR polymorphism is a genetic factor that may affect BMD in Korean women...
  79. ncbi Extended haplotypes and linkage disequilibrium in the IL1R1-IL1A-IL1B-IL1RN gene cluster: association with knee osteoarthritis
    A J P Smith
    University of Bristol Department of Pathology and Microbiology, Homoeopathic Hospital Site, Cotham, Bristol, UK
    Genes Immun 5:451-60. 2004
    ..We explored the linkage between nine polymorphic loci in the IL1R1 promoter, eight in the IL1A-IL1B-IL1RN gene complex, and their association with osteoarthritis (OA), a common complex disease associated with ..
  80. ncbi Interleukin-1B polymorphism is associated with age at onset of Alzheimer's disease
    F L Sciacca
    Department of Neuroscience, Neuroimmunology Unit, AUSL2, via Cusmano 3, Caltanissetta, Italy
    Neurobiol Aging 24:927-31. 2003
    ..0001; odds ratio for early onset, 7.4). These data further support a role for inflammation-related genes in AD or indicate linkage disequilibrium with an unknown chromosome 2 locus...
  81. pmc A nuclear target for interleukin-1alpha: interaction with the growth suppressor necdin modulates proliferation and collagen expression
    Bo Hu
    Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh School of Medicine, Biomedical Science Tower South Wing, 7th Floor, 3500 Terrace Street, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 100:10008-13. 2003
  82. ncbi Polymorphisms in the IL-1A gene are correlated with levels of interleukin-1alpha protein in gingival crevicular fluid of teeth with severe periodontal disease
    S Shirodaria
    Department of Adult Oral Health, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, University of London, UK
    J Dent Res 79:1864-9. 2000
    ..These results suggest a mechanism whereby this genetic polymorphism acts to modulate IL-1alpha protein production and may influence the pathogenesis of periodontal disease by affecting the extent of IL-1-associated bystander damage...
  83. ncbi Cloning and functional analysis of the allelic polymorphism in the transcription regulatory region of interleukin-1 alpha
    Roberto Dominici
    Institute of Biomedical Sciences and Department of Neurology, Ospedale Luigi Sacco, Milan, Italy
    Immunogenetics 54:82-6. 2002
    ..The TT genotype significantly increased the transcriptional activity of the IL-1 alpha gene with respect to the CC genotype. A slight increase of the IL-1 alpha mRNA and protein levels was also observed in the plasma...
  84. ncbi C-reactive protein levels are influenced by common IL-1 gene variations
    Peter Berger
    Division of Cardiovascular Disease, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cytokine 17:171-4. 2002
    ..These data indicate that IL-1 gene polymorphisms known to affect the inflammatory response are highly related to plasma levels of CRP and fibrinogen in patients referred for coronary angiography...
  85. ncbi Normal tension glaucoma is not associated with the interleukin -1alpha (-889) genetic polymorphism
    Chun Yuan Wang
    Department of Ophthalmology, Taichung Veterans General Hospital, National Yang Ming University, Taiwan, Republic of China
    J Glaucoma 16:230-3. 2007
    ..IL-1alpha (-889) T allele polymorphism has been found to increase the risk of developing Alzheimer disease. The aim of this study was to test in a Chinese cohort the hypothesis that IL-1alpha (-889) polymorphism is associated with NTG...
  86. ncbi Contribution of single nucleotide polymorphisms of the IL1A gene to the cleavage of precursor IL-1alpha and its transcription activity
    Yasushi Kawaguchi
    Institute of Rheumatology, Tokyo Women s Medical University School of Medicine, 10 22 Kawada cho, Shinjuku ku, Tokyo, Japan
    Immunogenetics 59:441-8. 2007
    We previously demonstrated the association of IL1A gene single nucleotide polymorphisms (SNPs) with susceptibility to systemic sclerosis (SSc) patients...
  87. ncbi Association of interleukin-1 receptor antagonist gene polymorphisms with early onset periodontitis in Japanese
    Hideaki Tai
    Department of Periodontology, Faculty of Dentistry, Niigata University, Niigata, Japan
    J Clin Periodontol 29:882-8. 2002
  88. ncbi Long-term interleukin-1alpha treatment inhibits insulin signaling via IL-6 production and SOCS3 expression in 3T3-L1 adipocytes
    T Uno
    First Department of Internal Medicine, Faculty of Medicine, University of Toyama, Toyama, Japan
    Horm Metab Res 40:8-12. 2008
    ..These results suggest that the IL-1alpha-mediated deterioration of insulin signaling is largely due to the IL-6 production and SOCS3 induction in 3T3-L1 adipocytes...
  89. ncbi Polymorphism in the IL-1alpha (-889) locus associated with elevated risk of primary open angle glaucoma
    Chun Yuan Wang
    Department of Ophthalmology, Taichung Veterans General Hospital, National Yang Ming University, Taichung, Taiwan, Republic of China
    Mol Vis 12:1380-5. 2006
    ..In this report we have explored the possible association between the IL-1alpha (-889) polymorphism and the development of POAG...
  90. doi Polymorphisms in the interleukin-1 receptor antagonist and interleukin-6 genes affect risk of osteolysis in patients with total hip arthroplasty
    Andrew Gordon
    University of Sheffield, and Academic Unit of Bone Metabolism, Northern General Hospital, Sheffield, UK
    Arthritis Rheum 58:3157-65. 2008
  91. ncbi Association of an interleukin 1 alpha polymorphism with Alzheimer's disease
    Y Du
    Departments of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, 46202, USA
    Neurology 55:480-3. 2000
    ..The IL-1A(-889) allele 2 polymorphism may be associated with AD pathogenesis...
  92. ncbi Association between the interleukin-1 family gene cluster and psoriatic arthritis
    Proton Rahman
    Memorial University of Newfoundland, St Clare s Mercy Hospital, St John s, Newfoundland, Canada
    Arthritis Rheum 54:2321-5. 2006
    ..The loci in the IL1 gene cluster have recently been associated with ankylosing spondylitis (AS)...
  93. ncbi Association of the interleukin-1 gene cluster on chromosome 2q13 with knee osteoarthritis
    John Loughlin
    Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK
    Arthritis Rheum 46:1519-27. 2002
    ..To investigate whether the interleukin-1 (IL-1) ligand gene cluster at 2q13 encodes for genetic susceptibility to primary osteoarthritis (OA)...
  94. doi Association of Interleukin-1 gene polymorphisms with central obesity and metabolic syndrome in a coronary heart disease population
    Kim W Carter
    Western Australian Institute for Medical Research and UWA Centre for Medical Research, University of Western Australia, Perth, WA, Australia
    Hum Genet 124:199-206. 2008
  95. pmc Synergistic effect of interleukin 1 alpha on nontypeable Haemophilus influenzae-induced up-regulation of human beta-defensin 2 in middle ear epithelial cells
    Sung Kyun Moon
    The Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA, USA
    BMC Infect Dis 6:12. 2006
  96. doi Sustained IL-1alpha, IL-4, and IL-6 elevations following correction of hyperglycemia in children with type 1 diabetes mellitus
    Jaime S Rosa
    Department of Pharmacology, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA
    Pediatr Diabetes 9:9-16. 2008
  97. ncbi Interleukin-1-induced NF-kappaB recruitment to the oxytocin receptor gene inhibits RNA polymerase II-promoter interactions in cultured human myometrial cells
    Melvyn S Soloff
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX 77555 1062, USA
    Mol Hum Reprod 12:619-24. 2006
    ..Interleukin-1alpha (IL1A) treatment of cultured human myometrial cells has previously been shown to reduce steady-state levels of OTR mRNA...
  98. ncbi Endogenous interleukin-1 alpha promotes a proliferative and proinflammatory phenotype in human vascular smooth muscle cells
    Kelly Schultz
    Molecular Cardiology Research Institute, Tufts New England Medical Center, Box 8486, 750 Washington St, Boston, MA 02111, USA
    Am J Physiol Heart Circ Physiol 292:H2927-34. 2007
  99. pmc Association study of genetic variants of pro-inflammatory chemokine and cytokine genes in systemic lupus erythematosus
    Elena Sanchez
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
    BMC Med Genet 7:48. 2006
    ..The aim of this study was to evaluate the relevance of functional genetic variations of RANTES, IL-8, IL-1alpha, and MCP-1 for systemic lupus erythematosus...
  100. ncbi Association between TNF and IL-1 bloc polymorphisms and plasma MCP-1 concentration
    Hind Berrahmoune
    INSERM, U525, Equipe 4, Nancy, France
    Atherosclerosis 192:348-53. 2007
    ..We hypothesized that specific genetic polymorphisms in TNF, LTA, IL-1A and IL-1B genes could modulate plasma MCP-1 concentration...
  101. ncbi IL1HY1: A novel interleukin-1 receptor antagonist gene
    J J Mulero
    Functional Genomics Department, Immunology Group, Hyseq Inc, 670 Almanor Avenue, Sunnyvale, California 94086, USA
    Biochem Biophys Res Commun 263:702-6. 1999
    ..Furthermore, the message can be induced in THP-1 cells by phorbol ester (PMA) and lipopolysaccharide (LPS) treatment...

Research Grants62

  1. Proinflammatory Biomarkers and Post-Breast CancerLymphedema
    Mei Rosemary Fu; Fiscal Year: 2012
    ..biomarkers and candidate genes include lymphatic specific growth factors (VEGF-C &VEGF-D), cytokines (IL1-a, IL1-b, IL6, IL8, &IL10), and tumor necrosis factor-a...
  2. Optoid Analgesics: Modulation of Trigeminal & Spinal Glial Activation
    Linda Watkins; Fiscal Year: 2010
    ..effects of morphine, through the release of proinflammatory cytokines: tumor necrosis factor (TNF), interleukin-1 (IL1) &interleukin-6 (IL6)...
  3. Neuroimaging abnormalities in major depressive disorder: effect of inflammation
    Jonathan Savitz; Fiscal Year: 2013
    ..A post-hoc analysis with additional, commonly measured cytokines: IN?, IL2, IL4, IL5, IL1[unreadable], IL8, TNF[unreadable], and IL12p70 (hereafter bead array: BA cytokines) will also be conducted...
  4. Lifestyle and Molecular Factors of Bone Health in Breast Cancer Survivors
    Song Yao; Fiscal Year: 2013
    ..biomarkers, including BAP for bone formation and TRAP5b for resorption, six key regulatory cytokines (RANKL, OPG, IL1, IL6, TNF[unreadable], CSF), and 25-hydroxyvitamin D...
  5. Role of Interleukin-1 in mediating epithelial-dendritic cell crosstalk in the lun
    BART N contact LAMBRECHT; Fiscal Year: 2010
    ..Both hematopoietic and stromal cells can produce IL1[unreadable] and respond to it...
  6. Diet, Activity, and Lifestyle as a Risk Factor for Colorectal Cancer
    Martha L Slattery; Fiscal Year: 2012
    ..and evaluate haplotypes in candidate genes in an inflammation-related pathway (IL6, IL8, IL10, NFKB, TNF-A, IL4, IL1, ILIRA and IFNG) and genes located at key junctions where other cellular signaling pathways converge which we ..
  7. Mechanisms of abnormal enterochromaffin cell secretion in Crohn's disease
    Mark S Kidd; Fiscal Year: 2012
    ..Cytokines (particularly IL1[unreadable]) and bacterial lipopolysaccharides (LPS) and muramyl dipeptide (MDP) have been implicated in Crohn'..
  8. Neutrophil Accumulation in Bacterial Pneumonia
    Samithamby Jeyaseelan; Fiscal Year: 2013 human and mouse macrophages that regulates caspase-1 dependent maturation of the inflammatory cytokines, IL1[unreadable] and IL18. IL-1R1 knockout (KO) mice show greater susceptibility than NLRC4 KO mice to intrapulmonary K...
  9. A3AR agonists to prevent chemotherapy-induced painful peripheral neuropathy
    Daniela Salvemini; Fiscal Year: 2013
    ..We will focus on NF[unreadable]B &MAPK (ERK1/2, p38) signaling &glial-derived pro (TNF[unreadable], IL1[unreadable], &IL6)/anti (IL10)-inflammatory cytokines, as well as, the effects on the expression &..
  10. Interleukin-1: A Promoter of Slow Wave Sleep
    JAMES MARTIN KRUEGER; Fiscal Year: 2013
    ..metabolic syndrome, chronic inflammation, sleepiness, etc;can be elicited by administration of interleukin-1 beta (IL1) or related cytokines or can be prevented by blocking them...
  11. Understanding early events in lupus autoimmunity to aid prevention
    Judith A James; Fiscal Year: 2013 lupus-associated specificities across a spectrum of pre-clinical lupus collections, 2) evaluate the role of IL1 receptor antagonist:IL1beta ratios and BLyS levels, as well as other peripheral cytokine or chemokine measurements, ..
  12. Role of HOS in cell transformation and apoptosis
    Serge Y Fuchs; Fiscal Year: 2013
    ..accelerate IFNAR1 degradation and inhibit IFN1 signaling by secreting inflammatory cytokines such as interleukin 1 (IL1)...
    CRAIG CLARKSON; Fiscal Year: 2001
    ..evidence that infection with HIV-1 can stimulate the formation of inflammatory cytokines such as TNF-alpha and IL1-beta...
  14. Indoleamine 2, 3 dioxygenase signaling and function in Type 1 Diabetes
    Suparna Sarkar; Fiscal Year: 2009
    ..Immunohistochemically IDO was localized in more than one cell type in the islets. In addition, co exposure of IL1(, IFN( and TNF( to human islets resulted in induction of both IDO and inducible form of Nitrous oxide synthase (..
    LUCIA MADARIAGA; Fiscal Year: 2013
    ..Specifically, we will use antibodies to block the inflammatory cytokines IL-6 and IL1, and perfuse the donor graft ex vivo with a stabilizing perfusate...
  16. Inflammation Pathways in Breast Cancer
    Margaret M Madeleine; Fiscal Year: 2010
    ..We will evaluate whether polymorphisms in proinflammatory (IL1, IL6, IL8, IL12, TNF, and leptin) and anti- flammatory (IL1RN, IL2, IL10, adiponectin) genes and their receptors ..
  17. HER2 and the link between inflammation and cancer stem cells
    Hexin Chen; Fiscal Year: 2013
    ..signaling pathways responsible for induction of IL-1 expression in breast cancer cells and address whether IL1 in turn activates IL- 6 expression...
  18. Neural estrogen synthesis by astrocytic aromatization, and neuroinflammation.
    Colin J Saldanha; Fiscal Year: 2013
    ..Indeed, E-administration decreases the expression and secretion of several pro-inflammatory cytokines including IL1, IL6 and TNF?...
    Fabio Cominelli; Fiscal Year: 2000
    ..The ultimate goal of the present research proposal is to further characterize the pathogenesis of IBD by identifying those factors which contribute to the predisposition and perpetuation of chronic intestinal inflammation. ..
  20. Cranial Stimulation for Chemotherapy Symptoms in Breast Cancer
    Deborah B McGuire; Fiscal Year: 2013
    ..among selected markers of inflammation (tumor necrosis factor alpha [TNF-1], interleukin-6 [IL-6], interleukin-IL1-2 [IL1-2], and C-reactive protein [CRP]), symptoms and QOL;(2) examine whether the symptoms of depression, anxiety, ..
  21. A Redox-active PARP Inhibitor for Lung Transplantation
    ANDREW LURIE SALZMAN; Fiscal Year: 2012
    ..for determination of BALF cellularity, protein concentration, TNF-[unreadable], MIP-1[unreadable], IL6, and IL1-[unreadable]...
  22. Hybrid Katp Channel Opener and Redox Catalyst for Lung Transplantation
    Prakash Jagtap; Fiscal Year: 2013
    ..for determination of BALF cellularity, protein concentration, TNF-[unreadable], MIP-1[unreadable], IL-6, and IL1-[unreadable]...
  23. Connective tissue and nervous system mechanisms of CAM therapies for low back pai
    Helene M Langevin; Fiscal Year: 2013, areolar PCT cell-mediated tissue relaxation (ex vivo), markers of areolar PCT neurogenic inflammation (NGF, IL1-2 and TNF-1) and spinal cord Substance P and CGRP fiber density...
    Tariq M Haqqi; Fiscal Year: 2011
    ..the activation of signal transduction pathways and transcription factors which negatively or positively affect the IL1-(3 -induced transcription of genes associated with the catabolic or anabolic response in human chondrocytes"...
  25. Enteric Neuronal Development as a Determinant of Intestinal Inflammation
    Kara Gross Margolis; Fiscal Year: 2013
    ..differences from WT found in measures of the severity (edema, T cell and neutrophil infiltration, and expression of IL1 , IFN , and TNF ) of delayed type hypersensitivity evoked in the ears with dinitrofluorobenzene...
    DINESH TEWARI; Fiscal Year: 1999
    ..Consequently, an important therapeutic implication of the present proposal is that blockers of these IL-1 induced biochemical events could be useful clinically for the future treatment of periodontitis. ..
  27. Mesenchymal stem cell secretome in lung fibrosis: mitochondria and RNA shuttle
    Luis A Ortiz; Fiscal Year: 2013
    ..cells and we previously reported that beneficial effects of MSCs are mediated, in part, by their production of IL1 receptor antagonist that limits macrophage inflammation...
  28. The role of fractalkine signaling in neurodegenerative disease
    Richard M Ransohoff; Fiscal Year: 2013
    ..Additional studies in both the A? and MAPT models suggests that IL1 signaling may contribute to the CX3CR1 dependent alterations in AD brain pathologies...
  29. The role of microglial-and neuron-specific MyD88 signaling in tauopathies
    Kiran Bhaskar; Fiscal Year: 2013
    ..IL-1) released by reactive microglia induces MAPT phosphorylation in primary neurons via activating neuronal IL1-receptor (IL1-R) and p38 mitogen activated protein kinase (p38 MAPK) pathway...
  30. Efficacy of enteral glutamine in reducing bloodstream infections in SBS infants
    Conrad R Cole; Fiscal Year: 2012 NEC to evaluate the efficacy of GLN to decrease BSI (primary endpoint) and serial serum concentrations of TNF- , IL1- 2, IL-6 and IL-8 (secondary endpoint)...
  31. Molecular Mechanisms of Sleep Responses to Viral Infection
    JAMES MARTIN KRUEGER; Fiscal Year: 2013
    ..via molecular steps involving pathogen pattern recognition receptors in the OB, their induction of interleukin-1(IL1)-related molecules in the OB and HT and HT IL1/growth hormone releasing hormone (GHRH) mechanisms...
  32. Neural Correlates and Modifiers of Cognitive Aging
    Naftali Raz; Fiscal Year: 2013
    ..protein), elevated insulin, and genetic variants associated with vascular and metabolic risk (MTHFR C677T, IL1-p C511T, BDNF Val66Met, ACE l/D, ApoEpound4, diabetes risk genes, and polymorphisms related to specific ..
  33. Caregivers of Prolonged Mechanical Ventilation: Mind-Body Interaction Model
    Jiyeon Choi; Fiscal Year: 2010
    ..g., burden), behavioral (e.g., sleep) and biological (e.g., IL1) responses of acute and chronic stress over time and how those interactions are related to characteristics of care ..
  34. Heme degradation pathway and immunomodulation in prostate cancer.
    Barbara Wegiel; Fiscal Year: 2013
    ..cancer via modulation of macrophage activities: phagocytosis and cytokine production through Nalp3-caspase-1-IL1[unreadable] signaling pathway...
    Andrea Mastro; Fiscal Year: 1991
    ..Mitogenic lectins along with macro-phages induce production of interleukin 1 (IL1), interleukin 2 (IL2), and their receptors which interact to cause proliferation...
  36. Pattern Recognition Receptors and Autophagy in Mtb Control in AIDS
    VOJO P DERETIC; Fiscal Year: 2013
    ..We hypothesize that innate immunity receptors and mediators, specifically pattern recognition receptors (PRR) and IL1-[unreadable] receptor and their downstream signaling pathways induce autophagy as an antimycobacterial mechanism...
  37. Investigation of Platelet G-Protein Coupled Receptors
    Fadi T Khasawneh; Fiscal Year: 2013
    ..This finding suggests that the IL1 domain of TPR participates in receptor coupling to Gq, but not G13...
    JEFFREY TATRO; Fiscal Year: 2003
    ..roles of specific MCR subtypes, in mediating melanocortin-induced inhibition of endotoxin (LPS) and interleukin-1 (IL1) actions in the brain; and the role of hypothalamic neurons producing a novel endogenous MCR antagonist (agouti-..
    James Anderson; Fiscal Year: 1992
    ..demonstrate that significant biomedical polymers can selectively affect the activation, function and Interleukin 1 (IL1) and other Growth Factor production of tissue macrophages and this modulation of macrophage activity can be ..
  40. Cytokines Stimulate Prostate Epithelial Proliferation
    Wade Bushman; Fiscal Year: 2009
    ..We will test the biologic relevance IL-1R in prostate growth by examining the effect of genetic disruption of IL1-R1 on prostate development, epithelial and mesenchymal proliferation, and progenitor cell expansion...
  41. Neural Plasticity and Inflammatory Pain
    Clifford J Woolf; Fiscal Year: 2010
    ..that peripheral and central sensitization are both driven by the inflammatory mediators PGE2, bradykinin and IL1 beta...
    Anna Taylor; Fiscal Year: 2001
    ..response induced by a pathogen product, lipopolysaccharide (LPS), and one of the cytokines, interleukin-1 beta (IL1), induced by LPS. Moreover, maternal adrenalectomy was found to prevent the blunted febrile response...
    James Tam; Fiscal Year: 2002
    ..The specific aims are as follows: 1. Design and synthesis of antagonists of EGF/TGFalpha and IL1. 2. Develop domain ligation strategy for the synthesis of growth factor antagonists and mosaic proteins. 3...
    John Kasckow; Fiscal Year: 2002
    ..gene and peptide expression will be measured in the hypothalamus and pituitary following central interleukin-1 (IL1) challenge. Hippocampal corticosteroid binding will also be measured following central IL1...
    JAMES LARRICK; Fiscal Year: 1992
    ..Phase I application referred to this molecule as contra IL1 an inhibitor of IL1. Preliminary cell biological and immunological studies have revealed a unique set of properties...
  46. Molecular Epidemiology of ARDS and Septic Shock
    MICHELLE GONG; Fiscal Year: 2005
    ..For Aim 3, serum will be collected for the measurement of TNF-alpha, IL1-ra, IL-10, PAI-1 and TGF-1...
    Thomas Klein; Fiscal Year: 1993
    ..on other immune cells, including human B lymphocyte proliferation to a polyclonal activator, an cytokine (IL-6/TNF/IL1) production by NK cells and monocytes...
  48. Structural and Cellular Biology of GPH Receptors
    JAMES ALAN DIAS; Fiscal Year: 2010
    ..In addition, amino acids in FSHR-IL1 which are essential for interaction with APPL proteins will be determined so that binding defective mutants can be ..
    DAVID NEWBURG; Fiscal Year: 2003
    ..and measure individual Gb3/GaI Gb3 species in hGEC and hCEC cultures incubated with and without TNF-alpha and IL1-beta...
    Eugenie Kleinerman; Fiscal Year: 2001
    ..Plasma TNGa, IL-6, IL-8, IL1a, IL-1B, neopterin, IL-12, IFNy and peripheral blood monocyte tumoricidal activity will be monitored to this end ..
  51. Pharmacology of Antirheumatic Drugs
    Bruce Cronstein; Fiscal Year: 2007
    ..To this end we will examine Th1 cytokine (TNFalpha, IL1 and IFNgamma)-mediated regulation of expression and phosphorylation of G proteins, expression of protein kinase A, ..
    Robert Hall; Fiscal Year: 1999
    ..of secretion of IL-1 and TNF-alpha by human peripheral blood monocytes, and induction of accumulation of mRNAs for IL1- alpha, IL1-beta, lL6, and TNF-alpha in monocytes and monocyte-like cell lines...
    Aniruddha Ganguly; Fiscal Year: 2001
    ..Second, the expression of cytokines IL1-beta, TNF-alpha and IL-6 by the monocytes in response to CEA binding will be examined by ELISA and by Northern ..
    Floyd Bloom; Fiscal Year: 2000
    ..A fourth project will examine the cytokines IL1-beta, TNFalpha, and IL6, as well as HIV glycoproteins on cerebellar neuronal development in vitro...
    GRACIELA ALARCON; Fiscal Year: 2004
    ..ethnic groups; 3) to examine additional MHC-and non-MHC genes that have also been associated with SLE (TNF, MBP, IL1-RA, Bcl-2); 4) to refine the assessment of those clinical, behavioral-cultural factors found to be important ..
    JAMES JESTER; Fiscal Year: 2003
    ..of keratocyte crystallins in vitro and determine the effects of light/dark and cytokine stimulation (TGFbeta, IL1, FGF2, PDGF) on crystalline protein expression; and (5) modulate keratocyte crystalline protein expression in vivo ..
    ABUL ABBAS; Fiscal Year: 1991
    ..ii) activation requirements, with emphasis on recognition of antigen on B and non-B antigen presenting cells and IL1 dependence...
    EILEEN REMOLD O DONNELL; Fiscal Year: 1992
    ..expression of Class II histocompatibility antigens, the expression of the secreted monokines IL6, TNF-alpha, and IL1-beta, and the expression of the granule-associated cytotoxic peptides that are known collectively as "defensins"...
  59. H.pylori, genes and esophageal adenocarcinoma
    Geoffrey Liu; Fiscal Year: 2005
    ..will be evaluated as potential modifiers of this relationship: (a) genes in the inflammatory pathway, such as IL1-beta; (b) genes involved in free radical formation such as MPO and MnSOD; and (c) several candidate DNA repair ..
  60. Genetic & epidemiologic cohort study of asthma & allergy
    Susan Ewart; Fiscal Year: 2009
    ..and other allergies, we will investigate candidate genes thought to mediate allergic inflammation, IL4, IL4R, IL13, IL1 and IL1RN, in DNA samples collected from our cohort of children...
  61. IL-4 Potentiates T Cell Death in Autoimmune Arthritis
    Jian Zhang; Fiscal Year: 2006
    ..studies indicate that IL-4 can promote AICD by down regulating expression of Fas-associated death domain-like IL1 beta-converting enzyme inhibitory protein (FLIP) and up regulating FasL expression, and these effects are achieved ..
    Takashi Makinodan; Fiscal Year: 1990
    ..The specific aims and methods to test these hypotheses are: (i) To demonstrate the presence of membrane IL1 on human monocytes and correlate it with the monocyte mediated augmentation...