IL15RA

Summary

Gene Symbol: IL15RA
Description: interleukin 15 receptor subunit alpha
Alias: CD215, interleukin-15 receptor subunit alpha, interleukin 15 receptor alpha isoform EM2, interleukin 15 receptor alpha isoform IC2, interleukin 15 receptor alpha isoform IC3, interleukin 15 receptor alpha isoform IC4, interleukin 15 receptor alpha isoform IC5, interleukin 15 receptor alpha isoform IC6, interleukin 15 receptor alpha isoform IC7, interleukin 15 receptor alpha isoform IC8, interleukin 15 receptor, alpha
Species: human

Top Publications

  1. ncbi Normal Weight Obese syndrome: role of single nucleotide polymorphism of IL-1 5Ralpha and MTHFR 677C-->T genes in the relationship between body composition and resting metabolic rate
    L di Renzo
    Department of Neuroscience, Division of Human Nutrition, Tor Vergata University, Rome, Italy
    Eur Rev Med Pharmacol Sci 10:235-45. 2006
  2. pmc Interleukin-15 and interleukin-15R alpha SNPs and associations with muscle, bone, and predictors of the metabolic syndrome
    Emidio E Pistilli
    Department of Physiology and Pennsylvania Muscle Institute, University of Pennsylvania, 3700 Hamilton Walk, A601 Richards Building, Philadelphia, PA 19140, USA
    Cytokine 43:45-53. 2008
  3. doi The exon-3-encoded domain of IL-15ralpha contributes to IL-15 high-affinity binding and is crucial for the IL-15 antagonistic effect of soluble IL-15Ralpha
    Gregory Bouchaud
    INSERM, U892, Centre de Recherche en Cancérologie Nantes Angers, Groupe Cytokines et Récepteurs, Nantes, France Université de NANTES, IFR26, Nantes, France
    J Mol Biol 382:1-12. 2008
  4. ncbi Elucidation of the interleukin-15 binding site on its alpha receptor by NMR
    Nicole A Hanick
    Howard Hughes Medical Institute, Department of Molecular and Cellular Physiology, Stanford University School of Medicine, California 94305, USA
    Biochemistry 46:9453-61. 2007
  5. pmc NK cell survival mediated through the regulatory synapse with human DCs requires IL-15Ralpha
    Fabienne Brilot
    Laboratory of Viral Immunobiology and Christopher H Browne Center for Immunology and Immune Diseases, Rockefeller University, New York, New York 10065, USA
    J Clin Invest 117:3316-29. 2007
  6. pmc Converting IL-15 to a superagonist by binding to soluble IL-15R{alpha}
    Mark P Rubinstein
    Department of Immunology, IMM4, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 103:9166-71. 2006
  7. ncbi The structure of the interleukin-15 alpha receptor and its implications for ligand binding
    Inken Lorenzen
    Biochemisches Institut der Christian Albrechts Universität Kiel, Olshausenstrasse 40, 24118 Kiel, Germany
    J Biol Chem 281:6642-7. 2006
  8. ncbi Soluble interleukin-15 receptor alpha (IL-15R alpha)-sushi as a selective and potent agonist of IL-15 action through IL-15R beta/gamma. Hyperagonist IL-15 x IL-15R alpha fusion proteins
    Erwan Mortier
    INSERM, U601, Groupe de Recherche Cytokines et Récepteurs, Institut de Biologie, Nantes F 44093, France
    J Biol Chem 281:1612-9. 2006
  9. pmc How a cytokine is chaperoned through the secretory pathway by complexing with its own receptor: lessons from interleukin-15 (IL-15)/IL-15 receptor alpha
    Erwin H Duitman
    Department of Immunology and Cell Biology, Research Center Borstel, Parkallee 22, D 23845 Borstel, Germany
    Mol Cell Biol 28:4851-61. 2008
  10. ncbi Natural, proteolytic release of a soluble form of human IL-15 receptor alpha-chain that behaves as a specific, high affinity IL-15 antagonist
    Erwan Mortier
    Groupe de Recherche Cytokines et Récepteurs en Immunologie et Cancérologie, Département de cancérologie, Institut National de la Santé et de la Recherche Médicale Unité 601, Institut de Biologie, Nantes, France
    J Immunol 173:1681-8. 2004

Research Grants

  1. KARIN L GAENSLER; Fiscal Year: 2014
  2. Effie W Petersdorf; Fiscal Year: 2015
  3. Soluble TCR-IL15 Fusions as Targeted Therapeutics for Cancer
    Peter Rhode; Fiscal Year: 2009

Scientific Experts

  • Qiang Guo
  • LeBris S Quinn
  • Onur Boyman
  • T H Ottenhoff
  • Xiuping Liu
  • Susana N Diniz
  • K Kitaya
  • J M Mariner
  • I A Khan
  • Steven E Riechman
  • Emidio E Pistilli
  • Gregory Bouchaud
  • M Sarfarazi
  • H Asao
  • Cristina Bergamaschi
  • Erwan Mortier
  • Yein Gei Lai
  • Nan Shih Liao
  • Yannick Jacques
  • Peter Rhode
  • KARIN L GAENSLER
  • Effie W Petersdorf
  • Thomas A Waldmann
  • Jun Yin
  • Mau Sheng Hou
  • George N Pavlakis
  • Ariane Plet
  • L di Renzo
  • Elena Chertova
  • Barbara K Felber
  • Enping Hong
  • Vladimir V Anokhin
  • Ming Zhao
  • Shinichiro Yokota
  • Yuri T Utsunomiya
  • Grant O'Connell
  • Alicia Santos Savio
  • Suocheng Chen
  • Q L Duan
  • Shih Ting Huang
  • Yijun Shi
  • Inken Lorenzen
  • Fella Tamzalit
  • J C Morris
  • Elena Dozio
  • Haiyong Gu
  • Chao Liu
  • Liming Wang
  • Weifeng Tang
  • Lei Quan
  • Xu Wang
  • Monika Braun
  • Pierfrancesco Marra
  • Guowen Ding
  • Averil Ma
  • Clémentine Perrier
  • Yae Huei Liou
  • Suidong Ouyang
  • Juyoung Choi
  • Joachim Grötzinger
  • Jung Yoon Choe
  • György Vámosi
  • Raymond Sowder
  • Jenifer Bear
  • Jing Chen
  • Meghan J Chenoweth
  • Aaron M Ring
  • Emanuela Romano
  • Jürgen R Müller
  • Gilbert Aaron Lee
  • Dong Hwan Kim
  • Jerome Bernard
  • Sebastian Newrzela
  • Jessica Matesanz-Isabel
  • Mikkel L Hansen
  • Chin Ling Chang
  • Noriko Sato
  • Margherita Rosati
  • Candido Alicea
  • Zhongfu Wu
  • Mathias Rickert
  • K Christopher Garcia
  • CHRISTIAN MUNZ
  • Weixue Zhong
  • J Michael Estep
  • Sou Sakamoto
  • Bärbel I de Bakker
  • Cecile Badoual
  • Erwin H Duitman
  • M Bigioni

Detail Information

Publications84

  1. ncbi Normal Weight Obese syndrome: role of single nucleotide polymorphism of IL-1 5Ralpha and MTHFR 677C-->T genes in the relationship between body composition and resting metabolic rate
    L di Renzo
    Department of Neuroscience, Division of Human Nutrition, Tor Vergata University, Rome, Italy
    Eur Rev Med Pharmacol Sci 10:235-45. 2006
    ..Possession of wild type homozygotes genotypes regarding IL-15Ralpha cytokine and 677C-->T MTHFR enzyme characterised NWO individuals...
  2. pmc Interleukin-15 and interleukin-15R alpha SNPs and associations with muscle, bone, and predictors of the metabolic syndrome
    Emidio E Pistilli
    Department of Physiology and Pennsylvania Muscle Institute, University of Pennsylvania, 3700 Hamilton Walk, A601 Richards Building, Philadelphia, PA 19140, USA
    Cytokine 43:45-53. 2008
    ..04), and baseline muscle quality (p=0.04). All associations were consistent in showing a potential involvement of the IL-15 pathway with muscle and bone phenotypes and predictors of metabolic syndrome...
  3. doi The exon-3-encoded domain of IL-15ralpha contributes to IL-15 high-affinity binding and is crucial for the IL-15 antagonistic effect of soluble IL-15Ralpha
    Gregory Bouchaud
    INSERM, U892, Centre de Recherche en Cancérologie Nantes Angers, Groupe Cytokines et Récepteurs, Nantes, France Université de NANTES, IFR26, Nantes, France
    J Mol Biol 382:1-12. 2008
    ..The soluble IL-15Ralpha sushi domain-IL-15 fusion protein is therefore able to bind and activate both the IL-15Rbeta/gamma and the IL-15Ralpha/beta/gamma receptors...
  4. ncbi Elucidation of the interleukin-15 binding site on its alpha receptor by NMR
    Nicole A Hanick
    Howard Hughes Medical Institute, Department of Molecular and Cellular Physiology, Stanford University School of Medicine, California 94305, USA
    Biochemistry 46:9453-61. 2007
    ..Our results predict that the binding surface on IL-15Ralpha involves strands C and D, similar to IL-2Ralpha. The interface, as predicted here, leaves open the possibility of trans-presentation of IL-15 by IL-15Ralpha on an opposing cell...
  5. pmc NK cell survival mediated through the regulatory synapse with human DCs requires IL-15Ralpha
    Fabienne Brilot
    Laboratory of Viral Immunobiology and Christopher H Browne Center for Immunology and Immune Diseases, Rockefeller University, New York, New York 10065, USA
    J Clin Invest 117:3316-29. 2007
    ..We suggest that this synapse formation enables optimal NK cell activation by DCs during innate immune responses...
  6. pmc Converting IL-15 to a superagonist by binding to soluble IL-15R{alpha}
    Mark P Rubinstein
    Department of Immunology, IMM4, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 103:9166-71. 2006
    ..Significantly, the results with IL-2, a soluble cytokine, are quite different; thus, IL-2 function is markedly inhibited by binding to soluble IL-2Ralpha...
  7. ncbi The structure of the interleukin-15 alpha receptor and its implications for ligand binding
    Inken Lorenzen
    Biochemisches Institut der Christian Albrechts Universität Kiel, Olshausenstrasse 40, 24118 Kiel, Germany
    J Biol Chem 281:6642-7. 2006
    ..IL-15Ralpha complex, which is essential for the biological effects of this important cytokine and which is not observed in other cytokine/cytokine receptor complexes...
  8. ncbi Soluble interleukin-15 receptor alpha (IL-15R alpha)-sushi as a selective and potent agonist of IL-15 action through IL-15R beta/gamma. Hyperagonist IL-15 x IL-15R alpha fusion proteins
    Erwan Mortier
    INSERM, U601, Groupe de Recherche Cytokines et Récepteurs, Institut de Biologie, Nantes F 44093, France
    J Biol Chem 281:1612-9. 2006
    ..Such hyper-IL-15 fusion proteins appear to constitute potent adjuvants for the expansion of lymphocyte subsets...
  9. pmc How a cytokine is chaperoned through the secretory pathway by complexing with its own receptor: lessons from interleukin-15 (IL-15)/IL-15 receptor alpha
    Erwin H Duitman
    Department of Immunology and Cell Biology, Research Center Borstel, Parkallee 22, D 23845 Borstel, Germany
    Mol Cell Biol 28:4851-61. 2008
    ....
  10. ncbi Natural, proteolytic release of a soluble form of human IL-15 receptor alpha-chain that behaves as a specific, high affinity IL-15 antagonist
    Erwan Mortier
    Groupe de Recherche Cytokines et Récepteurs en Immunologie et Cancérologie, Département de cancérologie, Institut National de la Santé et de la Recherche Médicale Unité 601, Institut de Biologie, Nantes, France
    J Immunol 173:1681-8. 2004
    ..These results suggest that IL-15R alpha shedding may play important immunoregulatory functions...
  11. pmc Treatment with soluble interleukin-15Ralpha exacerbates intracellular parasitic infection by blocking the development of memory CD8+ T cell response
    Imtiaz A Khan
    Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Science Center, New Orleans, LA 70112, USA
    J Exp Med 195:1463-70. 2002
    ..gondii challenge. To our knowledge, this is the first demonstration of the important role of host IL-15 in the development of antigen-specific memory CD8+ T cells against an intracellular infection...
  12. doi Tissue-specific expression of IL-15RA alternative splicing transcripts and its regulation by DNA methylation
    Susana N Diniz
    Immunogenetic Division, Federal University of Sao Paulo UNIFESP, Sao Paulo, SP, Brazil
    Eur Cytokine Netw 21:308-18. 2010
    ..Therefore, this work shows a broad expression pattern of functional IL-15RA splicing forms and suggests a regulatory role of DNA methylation in IL-15RA transcript Var1 expression in mononuclear cells...
  13. pmc Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor
    J G Giri
    Immunex Research and Development Corporation, Seattle, WA 98101, USA
    EMBO J 14:3654-63. 1995
    ..IL-15R alpha is structurally similar to IL-2R alpha; together they define a new cytokine receptor family. The distribution of IL-15 and IL-15R alpha mRNA suggests that IL-15 may have biological activities distinct from IL-2...
  14. ncbi Human T cell lymphotropic virus type I Tax activates IL-15R alpha gene expression through an NF-kappa B site
    J M Mariner
    Metabolism Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 166:2602-9. 2001
    ..These findings suggest a role for IL-15Ralpha in aberrant T cell proliferation observed in HTLV-I-associated diseases...
  15. ncbi IL-15/IL-15Ralpha intracellular trafficking in human melanoma cells and signal transduction through the IL-15Ralpha
    R Pereno
    U506 INSERM Hôpital Paul Brousse 94807 Villejuif, France
    Oncogene 19:5153-62. 2000
    ..Thus, IL-15Ralpha controls NF-kappaB activation, however differences in the intracellular trafficking of the IL-15 and/or IL-15Ralpha suggest a different biological role for this complex in MELP versus MELREO cells...
  16. ncbi Natural splicing of exon 2 of human interleukin-15 receptor alpha-chain mRNA results in a shortened form with a distinct pattern of expression
    S Dubois
    Groupe de Recherche Cytokines et Récepteurs, Unité INSERM 463, Institut de Biologie, 9 quai Moncousu, 44035 Nantes Cedex 01, France
    J Biol Chem 274:26978-84. 1999
    ..Together, our data indicate that exon 2 splicing of human IL-15Ralpha is a natural process that might play regulatory roles at different levels...
  17. ncbi Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes
    D M Anderson
    Department of Molecular Biology, Immunex Corporation, Seattle, Washington 98101, USA
    J Biol Chem 270:29862-9. 1995
    ..Furthermore, the IL15RA and IL2RA genes have a similar intron-exon organization and are closely linked in both human and murine genomes...
  18. pmc Circulating IL-15 exists as heterodimeric complex with soluble IL-15Rα in human and mouse serum
    Cristina Bergamaschi
    Human Retrovirus Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    Blood 120:e1-8. 2012
    ..Analysis of the form of IL-15 present in either normal or lymphodepleted mice agrees with the human data. These results have important implications for development of assays and materials for clinical applications of IL-15...
  19. pmc TNF stimulates nuclear export and secretion of IL-15 by acting on CRM1 and ARF6
    Suidong Ouyang
    Pennington Biomedical Research Center, Baton Rouge, Louisana, United States of America
    PLoS ONE 8:e69356. 2013
    ..We conclude that TNF abolishes nuclear localization of IL-15 and IL-15Rα by acting on CRM1, and it facilitates exocytosis of IL-15 with the involvement of ARF6. ..
  20. pmc Epidermal IL-15Rα acts as an endogenous antagonist of psoriasiform inflammation in mouse and man
    Gregory Bouchaud
    Laboratory of Applied Immunobiology and 2 Department of Dermatology, University of Zurich, 8006 Zurich, Switzerland
    J Exp Med 210:2105-17. 2013
    ..Thus, stressed epidermal stromal cells use soluble IL-15Rα to dampen chronic inflammatory skin disease. ..
  21. doi Muscle-specific deletion of exons 2 and 3 of the IL15RA gene in mice: effects on contractile properties of fast and slow muscles
    Grant O'Connell
    Division of Exercise Physiology, West Virginia University, Morgantown, West Virginia
    J Appl Physiol (1985) 118:437-48. 2015
    ..Collectively, these data support a direct effect of muscle IL-15Rα deficiency in altering contractile properties and fatigue characteristics in skeletal muscles. ..
  22. pmc NK cell activation in human hantavirus infection explained by virus-induced IL-15/IL15Rα expression
    Monika Braun
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    PLoS Pathog 10:e1004521. 2014
    ..The results add further insights into mechanisms behind the immunopathogenesis of hantavirus infections in humans and identify new possible targets for intervention. ..
  23. pmc Previously Unidentified Single Nucleotide Polymorphisms in HIV/AIDS Cases Associate with Clinical Parameters and Disease Progression
    Vladimir V Anokhin
    Kazan State Medical University, 49 Butlerova St, Kazan 420012, Russia Republican Clinical Hospital for Infectious Disease named after Agafonov, 83 Prospect Pobedy St, Kazan 420140, Russia
    Biomed Res Int 2016:2742648. 2016
    ..SNPs that associated with an increased viral load were identified in the genes for the interleukin 15 receptor (IL15RA), toll-like receptor 7 (TLR7), tripartite motif-containing protein 5 (TRIM5), and two killer-..
  24. doi IL-15 receptor alpha rs2228059 A>C polymorphism was associated with a decreased risk of esophageal cancer in a Chinese population
    Jun Yin
    Department of Cardiothoracic Surgery, Affiliated People s Hospital of Jiangsu University, Zhenjiang, 212002, China
    Mol Biol Rep 41:1951-7. 2014
    ..However, the statistical power of our study was limited because of the moderate sample size and absence of a validation cohort. Large well-designed studies are warranted to confirm our findings...
  25. pmc Vaccination with tumor cells expressing IL-15 and IL-15Rα inhibits murine breast and prostate cancer
    J C Morris
    1 Division of Hematology Oncology, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH, USA 2 Metabolism Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    Gene Ther 21:393-401. 2014
    ....
  26. pmc Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15
    Aaron M Ring
    Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California, USA
    Nat Immunol 13:1187-95. 2012
    ..Our results provide new insights for the development of specific immunotherapeutics based on IL-15 or IL-2...
  27. pmc Interleukin-15 and soluble interleukin-15 receptor α in coronary artery disease patients: association with epicardial fat and indices of adipose tissue distribution
    Elena Dozio
    Department of Biomedical Sciences for Health, Chair of Clinical Pathology, Universita degli Studi di Milano, Milan, Italy
    PLoS ONE 9:e90960. 2014
    ..Future studies on the relationship between IL-15, visceral fat and characteristics of atherosclerotic plaques could help to better understand the complex biology of this cytokine. ..
  28. doi Increased 5-hydroxymethylcytosine in CD4(+) T cells in systemic lupus erythematosus
    Ming Zhao
    Department of Dermatology, The Second Xiangya Hospital of Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, Hunan, PR China
    J Autoimmun 69:64-73. 2016
    ..e. SOCS1, NR2F6 and IL15RA, which were also confirmed by ChIP-qPCR...
  29. pmc IL-15.IL-15Rα complex shedding following trans-presentation is essential for the survival of IL-15 responding NK and T cells
    Fella Tamzalit
    Cancer Research Center Nantes Angers, Inserm Unité Mixte de Recherche 892, Centre National de la Recherche Scientifique 6299, University of Nantes, 44007 Nantes, France
    Proc Natl Acad Sci U S A 111:8565-70. 2014
    ..IL-15Rα complex cleaved from presenting cells allows responding cells to internalize, store and use IL-15.IL-15Rα complex for their own proliferation and survival. ..
  30. pmc Association between single nucleotide polymorphism of IL15RA gene with susceptibility to ossification of the posterior longitudinal ligament of the spine
    Qiang Guo
    Department of Spinal Surgery, Tianjin Baodi Hospital, No 8 Guangchuan Street, Baodi District, Tianjin, 301800, China
    J Orthop Surg Res 9:103. 2014
    Previous studies reported the association between single nucleotide polymorphism (SNP) of IL15 receptor alpha (IL15RA) gene with susceptibility to ossification of the posterior longitudinal ligament of the spine (OPLL)...
  31. doi The interleukin-15 system suppresses T cell-mediated autoimmunity by regulating negative selection and nT(H)17 cell homeostasis in the thymus
    Mau Sheng Hou
    Molecular Cell Biology, Taiwan International Graduate Program, Academia Sinica and Graduate Institute of Life Science, National Defense Medical Center, Taipei 115, Taiwan Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan
    J Autoimmun 56:118-29. 2015
    ..Here we found that Il15(-/-) and Il15ra(-/-) mice spontaneously developed late-onset autoimmune phenotypes...
  32. pmc Differential expression of pro-inflammatory cytokines IL-15Ralpha, IL-15, IL-6 and TNFalpha in synovial fluid from rheumatoid arthritis patients
    Alicia Santos Savio
    Pharmaceutical Division, Center for Genetic Engineering and Biotechnology, Havana, CP 10600, Cuba
    BMC Musculoskelet Disord 16:51. 2015
    ....
  33. pmc Configuration-dependent Presentation of Multivalent IL-15:IL-15Rα Enhances the Antigen-specific T Cell Response and Anti-tumor Immunity
    Enping Hong
    From the Department of Biomedical Engineering, Yale University, New Haven, Connecticut 06511
    J Biol Chem 291:8931-50. 2016
    ..The novel mechanism of IL-15 transfer to the surface of antigen-processing DCs may explain the enhanced potency of IL-15:IL-15Rα-coated nanoparticles for antigen delivery. ..
  34. pmc IRF-1 promotes liver transplant ischemia/reperfusion injury via hepatocyte IL-15/IL-15Rα production
    Shinichiro Yokota
    Thomas E Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261
    J Immunol 194:6045-56. 2015
    ..These results indicate that IRF-1 promotes LTx I/R injury via hepatocyte IL-15/IL-15Rα production and suggest that targeting IRF-1 and IL-15/IL-15Rα may be effective in reducing I/R injury associated with LTx...
  35. pmc Genome-Wide Scan for Visceral Leishmaniasis in Mixed-Breed Dogs Identifies Candidate Genes Involved in T Helper Cells and Macrophage Signaling
    Yuri T Utsunomiya
    Departamento de Medicina Veterinária Preventiva e Reprodução Animal, Faculdade de Ciencias Agrarias e Veterinarias, Unesp Univ Estadual Paulista, Jaboticabal, Sao Paulo, Brazil
    PLoS ONE 10:e0136749. 2015
    ..that serve as a cis-regulatory element for the expression of interleukin alpha receptors 2 (IL2RA) and 15 (IL15RA)...
  36. doi The distinct expressions of interleukin-15 and interleukin-15 receptor α in Behçet's disease
    Jung Yoon Choe
    Division of Rheumatology, Department of Internal Medicine, Arthritis and Autoimmunity Research Center, Catholic University of Daegu School of Medicine, 3056 6 Daemyung 4 dong, Namgu, Daegu 705 718, Republic of Korea
    Rheumatol Int 33:2109-15. 2013
    ..01 for SLE, p < 0.01 for RA, and p < 0.05 for BD). IL-15 and IL-15Rα system may be involved in the inflammatory process and pathogenesis of BD...
  37. doi Therapeutic potency of Poly I:C in HSV-induced inflammation through up-regulation of IL-15 receptor alpha
    Juyoung Choi
    Laboratory of Cell Biology, Institute for Medical Sciences, Ajou University, Suwon, Republic of Korea
    Immunobiology 218:1119-30. 2013
    ..In BD patients, the frequencies of IL-15Rα expression in PBMCs were also significantly different between the inactive and active disease states. These results suggest that IL-15Rα is a relevant factor in BD. ..
  38. pmc Cytokine and cytokine receptor genes of the adaptive immune response are differentially associated with breast cancer risk in American women of African and European ancestry
    Lei Quan
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY
    Int J Cancer 134:1408-21. 2014
    ..logistic regression found SNPs in genes important for T helper type 1 (Th1) immunity (IFNGR2 rs1059293, IL15RA rs2296135, LTA rs1041981), Th2 immunity (IL4R rs1801275), and T regulatory cell-mediated immunosuppression (TGFB1 ..
  39. doi IL15RA drives antagonistic mechanisms of cancer development and immune control in lymphocyte-enriched triple-negative breast cancers
    Pierfrancesco Marra
    Breakthrough Breast Cancer Research Unit, Department of Research Oncology, Guy s Hospital, King s College London School of Medicine, London, United Kingdom
    Cancer Res 74:4908-21. 2014
    ..an explanation for this apparent conundrum by defining TNBC cell subsets that overexpress the IL15 immune receptor IL15RA. This receptor usually forms a heterotrimer with the IL2 receptors IL2RB and IL2RG, which regulates the ..
  40. doi Interleukin 15 receptor alpha rs2228059 A > C polymorphism decreased risk of gastric cardiac adenocarcinoma in a Chinese population
    Jun Yin
    Department of Cardiothoracic Surgery, Affiliated People s Hospital of Jiangsu University, Zhenjiang, 212002, China
    Tumour Biol 35:6593-600. 2014
    ..case-control study to evaluate the genetic effects of interleukin 15 (IL15) and IL15 receptor alpha (IL15RA) functional single nucleotide polymorphisms (SNPs) on the pathogenesis of GCA...
  41. pmc Increased serum soluble IL-15Rα levels in T-cell large granular lymphocyte leukemia
    Jing Chen
    Metabolism Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892 1374, USA
    Blood 119:137-43. 2012
    ..It is conceivable that higher IL-15Rα expression may lower IL-15 response threshold in vivo and, therefore, may contribute to the pathogenesis of the disease...
  42. doi IL-15 can signal via IL-15Rα, JNK, and NF-κB to drive RANTES production by myeloid cells
    Meghan J Chenoweth
    Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre and Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario L8S 4K1, Canada
    J Immunol 188:4149-57. 2012
    ..Additional insights into IL-15 biology may lead to novel therapies aimed at bolstering targeted immune responses against cancer and infectious disease...
  43. pmc Retroviral insertional mutagenesis can contribute to immortalization of mature T lymphocytes
    Sebastian Newrzela
    Senckenberg Institute of Pathology, Goethe University Hospital Frankfurt, Frankfurt am Main, Germany
    Mol Med 17:1223-32. 2011
    ..The retroviral integration site (RIS) was found to be near the IL2RA and IL15RA genes...
  44. pmc Human Langerhans cells use an IL-15R-α/IL-15/pSTAT5-dependent mechanism to break T-cell tolerance against the self-differentiation tumor antigen WT1
    Emanuela Romano
    Laboratory of Cellular Immunobiology, Immunology Program, Sloan Kettering Institute for Cancer Research, New York, NY 10065, USA
    Blood 119:5182-90. 2012
    ..These data support the use of mRNA-electroporated LCs, or moDCs supplemented with exogenous rhuIL-15, as vaccines for cancer immunotherapy to break tolerance against self-differentiation antigens shared by tumors...
  45. pmc Genome-wide expression profiling identifies type 1 interferon response pathways in active tuberculosis
    Tom H M Ottenhoff
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 7:e45839. 2012
    ..Further analysis revealed IL15RA, UBE2L6 and GBP4 as molecules involved in the type-I interferon response in all three experimental models...
  46. pmc Interleukin-15 receptor α expression in inflammatory bowel disease patients before and after normalization of inflammation with infliximab
    Clémentine Perrier
    Department of Gastroenterology, Translational Research Centre for Gastrointestinal Disorders TARGID, KU Leuven, Leuven, Belgium
    Immunology 138:47-56. 2013
    ..Expression is localized in B cells, suggesting that IL-15 regulates B-cell functions during bowel inflammation. No change in release of sIL-15Rα is observed in patients treated with IFX...
  47. pmc Paracrine and transpresentation functions of IL-15 are mediated by diverse splice versions of IL-15Rα in human monocytes and dendritic cells
    Jürgen R Müller
    Metabolism Branch, NCI, National Institutes of Health, Bethesda, MD 20892, USA
    J Biol Chem 287:40328-38. 2012
    ..IL-15 can either be transpresented by IL-15Rα or be secreted...
  48. pmc A genome-wide association study of bronchodilator response in asthmatics
    Q L Duan
    Channing Division of Network Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Pharmacogenomics J 14:41-7. 2014
    ..51 × 10(-6)). This study applied a robust approach for testing the genetic basis of BDR and identified novel loci associated with this drug response in asthmatics. ..
  49. doi Expression of interleukin-15 and its receptor on the surface of stimulated human umbilical vein endothelial cells
    Xiuping Liu
    College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China
    J Huazhong Univ Sci Technolog Med Sci 29:527-34. 2009
    ..The conclusion demonstrated from our results is that IFN-gamma and TNF-alpha play an important role in regulating the expression of IL-15 and IL-15Ralpha on the surface of HUVECs...
  50. pmc Characterization and favorable in vivo properties of heterodimeric soluble IL-15·IL-15Rα cytokine compared to IL-15 monomer
    Elena Chertova
    AIDS and Cancer Virus Program, SAIC Frederick Inc, Frederick National Laboratory, Frederick, Maryland 21702, USA
    J Biol Chem 288:18093-103. 2013
    ..These identified properties of heterodimeric IL-15 provide a strong rationale for the evaluation of this molecule for clinical applications. ..
  51. doi IL-15 modulates the balance between Bcl-2 and Bim via a Jak3/1-PI3K-Akt-ERK pathway to promote CD8αα+ intestinal intraepithelial lymphocyte survival
    Yein Gei Lai
    Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
    Eur J Immunol 43:2305-16. 2013
    ..we found that either overexpression of Bcl-2 or removal of Bim from CD8αα(+) iIELs promoted their survival in Il15ra(-/-) mice...
  52. ncbi Gene expression analysis of ELF-MF exposed human monocytes indicating the involvement of the alternative activation pathway
    Madeleine Lupke
    Division of Environmental Physiology, Institute of Cell Biology and Biosystems Technology, University of Rostock, Albert Einstein Str 3, D 18059 Rostock, Germany
    Biochim Biophys Acta 1763:402-12. 2006
    ..Significant regulations could be analyzed for 5 genes (expression >2- or <0.5-fold): IL15RA (Interleukin 15 receptor, alpha chain), EPS15R (Epidermal growth factor receptor pathway substrate 15 - like 1), ..
  53. pmc Development of an IL-15-autocrine CD8 T-cell leukemia in IL-15-transgenic mice requires the cis expression of IL-15Rα
    Noriko Sato
    Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Blood 117:4032-40. 2011
    ....
  54. doi Nanometer-scale organization of the alpha subunits of the receptors for IL2 and IL15 in human T lymphoma cells
    Bärbel I de Bakker
    Applied Optics Group, Faculty of Science and Technology, MESA Research Institute for Nanotechnology, University of Twente, PO Box 217, 7500 AE Enschede, The Netherlands
    J Cell Sci 121:627-33. 2008
    ..Our results should aid understanding the action of the IL2R-IL15R system in T cell function and also might contribute to the more rationale design of IL2R- or IL15R-targeted immunotherapy agents for treating human leukemia...
  55. ncbi Mapping of the interleukin 5 receptor gene to human chromosome 3 p25-p26 and to mouse chromosome 6 close to the Raf-1 locus with polymorphic tandem repeat sequences
    C O Jacob
    Syntex Research R7 201, Palo Alto, California 94304
    Mamm Genome 4:435-9. 1993
    ..With the mouse-specific IL5R tandem repeat sequence in recombinant inbred strains of mice, the Il5r gene was mapped to the distal part of mouse Chr 6 close to the Raf-1 locus...
  56. pmc Localization of the fourth locus (GLC1E) for adult-onset primary open-angle glaucoma to the 10p15-p14 region
    M Sarfarazi
    Department of Surgery, University of Connecticut Health Center, Farmington, CT 06030 1110, USA
    Am J Hum Genet 62:641-52. 1998
    ..A partial list of genes that positionally are considered as candidates includes NET1, PRKCT, ITIH2, IL2RA, IL15RA, IT1H2, hGATA3, the mRNA for open reading frame KIAA0019, and the gene for D123 protein.
  57. ncbi Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex
    H Asao
    Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Immunol 167:1-5. 2001
    ..The chemical cross-linking study reveals the direct binding of IL-21 to the gamma(c). These data clearly demonstrate that the gamma(c) is an indispensable subunit of the functional IL-21R complex...
  58. ncbi Reduced expression of Bcl-2 in CD8+ T cells deficient in the IL-15 receptor alpha-chain
    Tzong Shoon Wu
    Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan
    J Immunol 168:705-12. 2002
    ..The reduced Bcl-2 content in CD8(+) cells might result in survival defect and contribute to the reduction of CD8(+) cells in IL-15Ralpha(-/-)mice...
  59. ncbi Expression of IL-15 and IL-15 receptor isoforms in select structures of human fetal brain
    M Kurowska
    Department of Pathophysiology and Immunology, Institute of Rheumatology, Warsaw, Poland
    Ann N Y Acad Sci 966:441-5. 2002
    ..The constitutive, but distinct, expression of IL-15 and its receptors in select human fetal brain structures suggests that IL-15 plays a role in their development and physiology...
  60. ncbi IFN-gamma-independent synergistic effects of IL-12 and IL-15 induce anti-tumor immune responses in syngeneic mice
    Alberto Comes
    Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
    Eur J Immunol 32:1914-23. 2002
    ..These data show IFN-gamma-independent synergistic anti-tumor effects of IL-12 and IL-15, involving CD8+ cells and secondary chemokines and cytokines, such as TNF-alpha...
  61. ncbi Identification of an interleukin-15alpha receptor-binding site on human interleukin-15
    Jerome Bernard
    Groupe de Recherche Cytokines et Récepteurs, Unité INSERM 601, Institut de Biologie, 9 quai Moncousu, 44093 Nantes Cedex 01, France
    J Biol Chem 279:24313-22. 2004
    ..Finally, some of the IL-15 mutants generated in this study displayed agonist or antagonist properties and may be useful as therapeutic agents...
  62. pmc IL-2 and IL-15 receptor alpha-subunits are coexpressed in a supramolecular receptor cluster in lipid rafts of T cells
    György Vámosi
    Cell Biophysics Research Group of the Hungarian Academy of Sciences, Debrecen, Hungary
    Proc Natl Acad Sci U S A 101:11082-7. 2004
    ..In addition, both alpha-chains were at least partially homodimerized/oligomerized, which could be the basis of distinct signaling pathways by the two cytokines...
  63. ncbi Association of interleukin-15 protein and interleukin-15 receptor genetic variation with resistance exercise training responses
    Steven E Riechman
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, PA 15260, USA
    J Appl Physiol (1985) 97:2214-9. 2004
    ..chronic changes in IL-15 protein in plasma and characterizing genetic variation in the IL-15 receptor-alpha gene (IL15RA)...
  64. ncbi High-affinity CD25-binding IL-2 mutants potently stimulate persistent T cell growth
    Balaji M Rao
    Department of Chemical Engineering, Massachusetts Institute of Technology, Building 66 552, 77 Massachusetts Avenue, Cambridge, Massachusetts 01239, USA
    Biochemistry 44:10696-701. 2005
    ....
  65. ncbi Limiting {gamma}c expression differentially affects signaling via the interleukin (IL)-7 and IL-15 receptors
    Christine M Smyth
    Gene Therapy Research Unit, Children s Medical Research Institute and The Children s Hospital at Westmead, Australia
    Blood 110:91-8. 2007
    ..Collectively, these results confirm that signal transduction via the IL-15R, and hence NK ontogeny, is preferentially retained relative to the IL-7R as gammac expression becomes limiting...
  66. ncbi Genes regulated by interferon-gamma in human uterine microvascular endothelial cells
    Kotaro Kitaya
    Department of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Int J Mol Med 20:689-97. 2007
    ..The genes significantly up-regulated included chemokines (CXCL9, CXCL10, CCL8, IL15RA, and CCL5), enzymes (GBP5, TAP1, CYP27B1, SOD2, MX1, CASP1, and PTGES), and transcription factors (TFAP2C, IRF1, ..
  67. doi IFN-α primes T- and NK-cells for IL-15-mediated signaling and cytotoxicity
    Mikkel L Hansen
    Department of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark
    Mol Immunol 48:2087-93. 2011
    ....
  68. doi The soluble alpha chain of interleukin-15 receptor: a proinflammatory molecule associated with tumor progression in head and neck cancer
    Cecile Badoual
    EA 4054 Universite Paris Descartes, Faculté de Medecine Ecole Nationale Vétérinaire d Alfort, Maisons Alfort, France
    Cancer Res 68:3907-14. 2008
    ..Overall, these results support for the first time an original protumor role of sIL-15Ralpha in cancer...
  69. doi Expression of cytokine signaling genes in morbidly obese patients with non-alcoholic steatohepatitis and hepatic fibrosis
    J Michael Estep
    Center for Liver Diseases, Inova Fairfax Hospital, 3300 Gallows Road, Falls Church, VA, 22042, USA
    Obes Surg 19:617-24. 2009
    ..The aim of this study was to assess the association of hepatic fibrosis and NASH by evaluating the intrinsic differences in the inflammatory cytokine signaling in the visceral adipose tissue obtained from morbidly obese patients...
  70. ncbi Role of interleukin-15 receptor alpha polymorphisms in normal weight obese syndrome
    L di Renzo
    Department of Neuroscience, Division of Human Nutrition, University of Tor Vergata, Rome, Italy
    Int J Immunopathol Pharmacol 22:105-13. 2009
    ..Our data underscore previous findings that suggest a potential role of IL-15 cytokine in NWO syndrome...
  71. doi Contributions of interfacial residues of human Interleukin15 to the specificity and affinity for its private alpha-receptor
    Sou Sakamoto
    Department of Medical Genome Sciences, The University of Tokyo, Chiba, Japan
    J Mol Biol 389:880-94. 2009
    ..IL15Ralpha complex, together with interactions in Region 3 of the interleukin, poses a stark contrast with the structurally related and sometimes functionally redundant interleukin 2...
  72. doi Transcriptional profiles during the differentiation and maturation of monocyte-derived dendritic cells, analyzed using focused microarrays
    Weixue Zhong
    Institute of Biotechnology and Clinical Immunology Research Laboratory of Jiangsu Province, Soochow University, Suzhou, PR China
    Cell Mol Biol Lett 14:587-608. 2009
    ..The correlative expression kinetics of the gene pairs IL1R1/IL1R2, IL15/IL15RA, DC-SIGN/ICAM-2 and DC-SIGN/ICAM-3 imply that they all play crucial roles in mediating DC functions...
  73. doi Secretion and biological activity of short signal peptide IL-15 is chaperoned by IL-15 receptor alpha in vivo
    Cristina Bergamaschi
    Human Retrovirus Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702 1201, USA
    J Immunol 183:3064-72. 2009
    ..Expression of both SSP and LSP forms of IL-15 appears to be conserved in many mammals, suggesting that SSP may be important for expressing a form of IL-15 with lower magnitude or duration of biological effects...
  74. doi IL-15R alpha-IgG1-Fc enhances IL-2 and IL-15 anti-tumor action through NK and CD8+ T cells proliferation and activation
    Zhongfu Wu
    Research and Development Department, Zhongying Stem Cell Bioengineering Co, Ltd, Chu Tian Road 88, Binjiang, Hangzhou 310052, China
    J Mol Cell Biol 2:217-22. 2010
    ..These data support clinical testing IL-2/IL-15Ralpha-IgG1-Fc expanded NK cells in patients with prostate cancer and CLL...
  75. doi New B-cell CD molecules
    Jessica Matesanz-Isabel
    Immunology Unit, Department of Cell Biology, Immunology and Neurosciences, Medical School, University of Barcelona, C Casanova 143, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    Immunol Lett 134:104-12. 2011
    ..HLDA9) eighteen new CDs were allocated to cell-surface molecules expressed on B cells: CD210a (IL10RA), CD215 (IL15RA), CD270 (TNFRSF14), CD307a (FCRL1), CD307b (FCRL2), CD307c (FCRL3), CD307d (FCRL4), CD351 (FCAMR), CD352 (SLAMF6), ..
  76. pmc Interleukin-15, IL-15 Receptor-Alpha, and Obesity: Concordance of Laboratory Animal and Human Genetic Studies
    LeBris S Quinn
    Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle Institute for Biomedical and Clinical Research, and Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington, 1660 S Columbian Way, Seattle, WA 98108, USA
    J Obes 2011:456347. 2011
    ..The gene encoding this receptor, IL15RA, resides on human chromosome 10p, a location linked to obesity and type-2 diabetes...
  77. doi Association between interleukin 15 receptor, alpha (IL15RA) polymorphism and Korean patients with ossification of the posterior longitudinal ligament
    Dong Hwan Kim
    Department of Physical Medicine and Rehabilitation, School of Medicine, Kyung Hee University, Seoul 130 701, Republic of Korea
    Cytokine 55:343-6. 2011
    ..The purpose of this study was to investigate single nucleotide polymorphisms (SNPs) of the interleukin 15 receptor, alpha (IL15RA) gene as a risk factor in Korean patients with OPLL.
  78. doi IL-15Rα of radiation-resistant cells is necessary and sufficient for thymic invariant NKT cell survival and functional maturation
    Chin Ling Chang
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 11490, Taiwan
    J Immunol 187:1235-42. 2011
    ..Stage 3 thymic iNKT cells are specifically reduced in Il15ra(-/-) mice...
  79. doi Different NK cell developmental events require different levels of IL-15 trans-presentation
    Gilbert Aaron Lee
    Department of Life Sciences and Institute of Genome Sciences, National Yang Ming University, Taipei, Taiwan
    J Immunol 187:1212-21. 2011
    ..In summary, each examined developmental event required a particular level of IL-15 trans-presentation by accessory cells...
  80. pmc Loss of IL-15 receptor α alters the endurance, fatigability, and metabolic characteristics of mouse fast skeletal muscles
    Emidio E Pistilli
    Department of Physiology and Pennsylvania Muscle Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Clin Invest 121:3120-32. 2011
    ..Consistent with a conserved functional role in humans, a genetic association was found between a SNP in the IL15RA gene and endurance in athletes stratified by sport...
  81. pmc A promiscuous liaison between IL-15 receptor and Axl receptor tyrosine kinase in cell death control
    Vadim Budagian
    Department of Immunology and Cell Biology, Research Center Borstel, Borstel, Germany
    EMBO J 24:4260-70. 2005
    ..Thus, IL-15-induced protection from TNFalpha-mediated cell death involves a hitherto unknown IL-15 receptor complex, consisting of IL-15Ralpha and Axl RTK, and requires their reciprocal activation initiated by ligand-induced IL-15Ralpha...
  82. ncbi The IL-15R alpha chain signals through association with Syk in human B cells
    E Bulanova
    Department of Immunology and Cell Biology, Research Center Borstel, Borstel, Germany
    J Immunol 167:6292-302. 2001
    ....

Research Grants3

  1. KARIN L GAENSLER; Fiscal Year: 2014
    ..Studies will directly inform the design of a Phase 1 clinical AML vaccine trial at UCSF for patients >60, ineligible for HSCT. ..
  2. Effie W Petersdorf; Fiscal Year: 2015
    ..We identified a role for 1L1A, ILIB, IL6, and IL15RA gene variation in outcome and hypothesize that the survival disparities are in part due to ancestry-related ..
  3. Soluble TCR-IL15 Fusions as Targeted Therapeutics for Cancer
    Peter Rhode; Fiscal Year: 2009
    ..subunit which has the capability of stably binding to IL-15, allowing generation of heterodimeric scTCR-IL15/scTCR-IL15Ra complexes with increased antigen binding activity...