IL12B

Summary

Gene Symbol: IL12B
Description: interleukin 12B
Alias: CLMF, CLMF2, IL-12B, IMD28, IMD29, NKSF, NKSF2, interleukin-12 subunit beta, CLMF p40, IL-12 subunit p40, IL12, subunit p40, NK cell stimulatory factor chain 2, cytotoxic lymphocyte maturation factor 40 kDa subunit, interleukin 12, p40, interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40), interleukin-12 beta chain, natural killer cell stimulatory factor, 40 kD subunit
Species: human

Top Publications

  1. ncbi Functional haplotypes of IL-12B are associated with childhood atopic asthma
    Tomomitsu Hirota
    Laboratory for Genetics of Allergic Diseases, Single Nucleotide Polymorphism Research Center, Institute of Physical and Chemical Research RIKEN, Kanagawa, Japan
    J Allergy Clin Immunol 116:789-95. 2005
  2. ncbi Interleukin-12p40 gene (IL-12B) polymorphism and Type 1 diabetes mellitus in Japanese: possible role in subjects without having high-risk HLA haplotypes
    Jian Mei Yang
    Division of Endocrinology and Metabolism, Department of Medicine, Jichi Medical School, Yakushiji 3311 1, Minamikawachi, Tochigi 329 0498, Japan
    Diabetes Res Clin Pract 71:164-9. 2006
  3. doi Association of polymorphisms in the IL-18 and IL-12 genes with susceptibility to Type 1 diabetes in Turkish patients
    A E Altinova
    Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara, Turkey
    J Endocrinol Invest 33:451-4. 2010
  4. ncbi IL12B polymorphism and type 1 diabetes in the Italian population: a case-control study
    Lorenza Nisticò
    Institute of Cell Biology, CNR, Campus Buzzati Traverso, Monterotondo, Rome, Italy
    Diabetes 51:1649-50. 2002
  5. ncbi The IL12B 3' untranslated region DNA polymorphism is not associated with early-onset type 1 diabetes
    R M McCormack
    Department of Medical Genetics, Queen s University Belfast, Belfast, Northern Ireland
    Genes Immun 3:433-5. 2002
  6. ncbi Th1 cytokine polymorphisms in spanish patients with type 1 diabetes
    José L Santiago
    Immunology Department, Hospital Universitario San Carlos, Madrid, Spain
    Hum Immunol 66:897-902. 2005
  7. ncbi Differential effects of insulin-like growth factor-1 and atheroma-associated cytokines on cell proliferation and apoptosis in plaque smooth muscle cells of symptomatic and asymptomatic patients with carotid stenosis
    Guanghong Jia
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    Immunol Cell Biol 84:422-9. 2006
  8. pmc Variation in cytokine genes can contribute to severity of acetabular osteolysis and risk for revision in patients with ABG 1 total hip arthroplasty: a genetic association study
    Jiri Gallo
    Department of Orthopaedics, Teaching Hospital and Faculty of Medicine and Dentistry, Palacky University, I P Pavlova 6, Olomouc775 20, Czech Republic Laboratory of Immunogenomics, Faculty of Medicine and Dentistry, Palacky University, I P Pavlova 6, Olomouc 775 20, Czech Republic
    BMC Med Genet 10:109. 2009
  9. doi JNK1 and JNK2 differently regulate IL-12 production in THP-1 macrophage cells
    Mitsuyoshi Utsugi
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    Cytokine 51:127-31. 2010
  10. pmc A stabilized HIV-1 envelope glycoprotein trimer fused to CD40 ligand targets and activates dendritic cells
    Mark Melchers
    Laboratory of Experimental Virology, Department of Medical Microbiology Center for Infection and Immunity Amsterdam, Netherlands
    Retrovirology 8:48. 2011

Research Grants

  1. JAMES TILFORD ELDER; Fiscal Year: 2016
  2. Jean Laurent Casanova; Fiscal Year: 2016
  3. Jean Laurent Casanova; Fiscal Year: 2014
  4. Immunogenetics of Cervical Cancer A Family-Based Design
    Stephen Schwartz; Fiscal Year: 2005
  5. JAMES TILFORD ELDER; Fiscal Year: 2016
  6. Identification of Psoriatic Arthritis Genes
    JAMES TILFORD ELDER; Fiscal Year: 2013
  7. Lionel B Ivashkiv; Fiscal Year: 2016
  8. Genotyping the NPF Biobank for Psoriasis Susceptibility Genes
    JAMES TILFORD ELDER; Fiscal Year: 2010
  9. Pioneer factor interactions in embryonic stem cells
    Stephen T Smale; Fiscal Year: 2010
  10. IMMUNOGENETIC MECHANISMS OF VACCINE RESPONSE
    Gregory A Poland; Fiscal Year: 2010

Detail Information

Publications232 found, 100 shown here

  1. ncbi Functional haplotypes of IL-12B are associated with childhood atopic asthma
    Tomomitsu Hirota
    Laboratory for Genetics of Allergic Diseases, Single Nucleotide Polymorphism Research Center, Institute of Physical and Chemical Research RIKEN, Kanagawa, Japan
    J Allergy Clin Immunol 116:789-95. 2005
    ..Although associations between polymorphisms of IL-12B on chromosome 5q31-33 and asthma have been reported, the genetic influences of the polymorphisms and haplotype of IL-12B are unclear...
  2. ncbi Interleukin-12p40 gene (IL-12B) polymorphism and Type 1 diabetes mellitus in Japanese: possible role in subjects without having high-risk HLA haplotypes
    Jian Mei Yang
    Division of Endocrinology and Metabolism, Department of Medicine, Jichi Medical School, Yakushiji 3311 1, Minamikawachi, Tochigi 329 0498, Japan
    Diabetes Res Clin Pract 71:164-9. 2006
    ..The IL-12B 3'UTR A-C polymorphism would be considered as a supplementary risk factor to T1DM in conjunction with HLA haplotypes...
  3. doi Association of polymorphisms in the IL-18 and IL-12 genes with susceptibility to Type 1 diabetes in Turkish patients
    A E Altinova
    Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara, Turkey
    J Endocrinol Invest 33:451-4. 2010
    ..Recent studies have indicated that polymorphisms of the interleukin-18 (IL-18) and interleukin- 12 (IL-12) genes are associated with the development of Type 1 diabetes mellitus (T1DM) in some populations, but not all...
  4. ncbi IL12B polymorphism and type 1 diabetes in the Italian population: a case-control study
    Lorenza Nisticò
    Institute of Cell Biology, CNR, Campus Buzzati Traverso, Monterotondo, Rome, Italy
    Diabetes 51:1649-50. 2002
    ..We analyzed the same polymorphism in 470 Italian type 1 diabetic patients and 544 matched control subjects and found no evidence of association with the disease...
  5. ncbi The IL12B 3' untranslated region DNA polymorphism is not associated with early-onset type 1 diabetes
    R M McCormack
    Department of Medical Genetics, Queen s University Belfast, Belfast, Northern Ireland
    Genes Immun 3:433-5. 2002
    ..of a polymorphism (1188A allele; termed allele 1) in the 3' untranslated region (3'UTR) of the interleukin 12B (IL12B) gene which encodes the IL-12p40 subunit of the pro-inflammatory cytokine IL-12...
  6. ncbi Th1 cytokine polymorphisms in spanish patients with type 1 diabetes
    José L Santiago
    Immunology Department, Hospital Universitario San Carlos, Madrid, Spain
    Hum Immunol 66:897-902. 2005
    Several polymorphisms in regions where Th1 cytokines (IL12B and IFNG genes) are located were analyzed in 303 Spanish subjects with type 1 diabetes and compared with a control cohort (n = 548)...
  7. ncbi Differential effects of insulin-like growth factor-1 and atheroma-associated cytokines on cell proliferation and apoptosis in plaque smooth muscle cells of symptomatic and asymptomatic patients with carotid stenosis
    Guanghong Jia
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    Immunol Cell Biol 84:422-9. 2006
    ..The different expression and activity of cell cycle regulatory proteins could be responsible for apoptosis of VSMC and destabilization of atherosclerotic plaques...
  8. pmc Variation in cytokine genes can contribute to severity of acetabular osteolysis and risk for revision in patients with ABG 1 total hip arthroplasty: a genetic association study
    Jiri Gallo
    Department of Orthopaedics, Teaching Hospital and Faculty of Medicine and Dentistry, Palacky University, I P Pavlova 6, Olomouc775 20, Czech Republic Laboratory of Immunogenomics, Faculty of Medicine and Dentistry, Palacky University, I P Pavlova 6, Olomouc 775 20, Czech Republic
    BMC Med Genet 10:109. 2009
    ..This may be driven by functional polymorphisms in the genes for cytokines and cytokine receptors involved in the development of osteolysis in THA, thereby having an effect on the individual's phenotype...
  9. doi JNK1 and JNK2 differently regulate IL-12 production in THP-1 macrophage cells
    Mitsuyoshi Utsugi
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    Cytokine 51:127-31. 2010
    ....
  10. pmc A stabilized HIV-1 envelope glycoprotein trimer fused to CD40 ligand targets and activates dendritic cells
    Mark Melchers
    Laboratory of Experimental Virology, Department of Medical Microbiology Center for Infection and Immunity Amsterdam, Netherlands
    Retrovirology 8:48. 2011
    ..We have previously stabilized soluble trimeric mimics of Env by introducing a disulfide bond between gp120 and gp41 and adding a trimer stabilizing mutation in gp41 (SOSIP.R6 gp140)...
  11. pmc IL-12 and GM-CSF in DNA/MVA immunizations against HIV-1 CRF12_BF Nef induced T-cell responses with an enhanced magnitude, breadth and quality
    Ana María Rodríguez
    Centro Nacional de Referencia para el SIDA, Universidad de Buenos Aires, Buenos Aires, Argentina
    PLoS ONE 7:e37801. 2012
    ..These relevant results contribute to the design of strategies aimed to induce T-cell responses against HIV antigens with higher quality...
  12. ncbi IL-12 delivery from recombinant vaccinia virus attenuates the vector and enhances the cellular immune response against HIV-1 Env in a dose-dependent manner
    M M Gherardi
    Department of Molecular and Cellular Biology, Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Cientificas, Campus Universidad Autonoma, Madrid, Spain
    J Immunol 162:6724-33. 1999
    ..This approach can be of wide vaccination interest as a means to improve immune responses to other Ags...
  13. ncbi HIV-1 Nef impairs the dynamic of DC/NK crosstalk: different outcome of CD56(dim) and CD56(bright) NK cell subsets
    Maria Giovanna Quaranta
    Department of Drug Research and Evaluation, Istituto Superiore di Sanita, Viale Regina Elena, 299, 00161 Rome, Italy
    FASEB J 21:2323-34. 2007
    ..Our findings suggest that the Nef-induced dysregulation in the DC/NK cell crosstalk may represent a potential mechanism through which HIV escapes innate immune surveillance...
  14. doi Monocyte-derived dendritic cells from HIV type 1-infected individuals show reduced ability to stimulate T cells and have altered production of interleukin (IL)-12 and IL-10
    Sandrine Buisson
    Department of Immunology, Faculty of Medicine, Imperial College, and Department of HIV GU Medicine, Chelsea and Westminster Hospital, London, United Kingdom
    J Infect Dis 199:1862-71. 2009
    ..Our findings suggest that MDDCs used in therapeutic vaccination of HIV-infected individuals may show reduced potency...
  15. pmc Intranasal vaccination using interleukin-12 and cholera toxin subunit B as adjuvants to enhance mucosal and systemic immunity to human immunodeficiency virus type 1 glycoproteins
    Diana I Albu
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York 12208, USA
    J Virol 77:5589-97. 2003
    ....
  16. ncbi HIV-1 Nef triggers Vav-mediated signaling pathway leading to functional and morphological differentiation of dendritic cells
    Maria Giovanna Quaranta
    Department of Immunology, Istituto Superiore di Sanità Viale Regina Elena, 299 00161 Rome, Italy
    FASEB J 17:2025-36. 2003
    ..Our results highlight how Nef may enhance T lymphocyte activation, thus fostering virus dissemination, manipulating the DC arm of the immune response...
  17. ncbi Active cellular infection of myeloid cells is required for HIV-1-mediated suppression of interleukin-12 p40 expression
    Kelley A Chambers
    Ottawa Health Research Institute, Ottawa, Ont, Canada
    Cell Immunol 215:120-32. 2002
    ....
  18. ncbi HIV-1 matrix protein p17 enhances the proliferative activity of natural killer cells and increases their ability to secrete proinflammatory cytokines
    Marco Vitale
    Department of Anatomy, Pharmacology and Forensic Medicine, Ospedale Maggiore, University of Parma, Italy
    Br J Haematol 120:337-43. 2003
    ..The property of p17 to increase the production of TNF-alpha and IFN-gamma might be a mechanism used by HIV-1 to modulate the immune system to support its replication and spreading...
  19. ncbi No evidence for association between the polymorphism in the 3' untranslated region of interleukin-12B and human susceptibility to tuberculosis
    Xin Ma
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Infect Dis 188:1116-8. 2003
    ..Our results suggest that IL-12B 3' UTR has no effect or has a negligible effect on human susceptibility to TB...
  20. doi Mechanism of 1α,25-dihydroxyvitamin D(3)-dependent repression of interleukin-12B
    Petra Gynther
    Department of Biosciences, University of Eastern Finland, FI 70211 Kuopio, Finland
    Biochim Biophys Acta 1813:810-8. 2011
    ..We suggest that these repressive epigenetic changes eventually cause down-regulation of IL-12 expression. This article is part of a Special Issue entitled: 11th European Symposium on Calcium...
  21. ncbi The immunoregulatory effects of HIV-1 Nef on dendritic cells and the pathogenesis of AIDS
    Maria Giovanna Quaranta
    Department of Drug Research and Evaluation, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    FASEB J 20:2198-208. 2006
    ....
  22. doi HIV-1 Tat addresses dendritic cells to induce a predominant Th1-type adaptive immune response that appears prevalent in the asymptomatic stage of infection
    Emanuele Fanales-Belasio
    National AIDS Center, Istituto Superiore di Sanita, Rome, Italy
    J Immunol 182:2888-97. 2009
    ....
  23. ncbi Differential expression of cytokine genes in HIV-1 tat transfected T and B cell lines
    V Sharma
    Division of Hematology and Oncology, Arthur G James Cancer Hospital and Research Institute, Ohio State University, Columbus 43210
    Biochem Biophys Res Commun 208:704-13. 1995
    ....
  24. ncbi Induction of cytokines by HIV-1 and its gp120 protein in human peripheral blood monocyte/macrophages and modulation of cytokine response during differentiation
    S Gessani
    Laboratory of Virology, Istituto Superiore di Sanita, Rome, Italy
    J Leukoc Biol 62:49-53. 1997
    ....
  25. pmc Human immunodeficiency virus type 1 gp120 induces abnormal maturation and functional alterations of dendritic cells: a novel mechanism for AIDS pathogenesis
    Laura Fantuzzi
    Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    J Virol 78:9763-72. 2004
    ..The finding that gp120 induces abnormal maturation of DCs linked to profound suppression of their activities unravels a novel mechanism by which HIV can lead to immune dysfunction in AIDS patients...
  26. ncbi Skewed expression and up-regulation of the IL-12 and IL-18 receptors in resting and activated CD4 T cells from HIV-1-infected patients
    Guillermo Robert de Arquer
    Fundacio irsiCaixa, HIVACAT, Hospital Universitari Germans Trias i Pujol, Ctra Canyet sn, 08916 Badalona, Spain
    J Leukoc Biol 82:72-8. 2007
    ..Furthermore, the percentage of IL-12Rbeta1-positive cells correlated inversely with the CD4 nadir of patients, suggesting that deregulation of the IL-12 and IL-18 pathways may play a role in the immunopathogenesis of HIV-1 infection...
  27. doi The relationship between ApoE, TNFA, IL1a, IL1b and IL12b genes and HIV-1-associated dementia
    L A Pemberton
    Centre for Immunology, St Vincent s Hospital, Darlinghurst, NSW, Australia
    HIV Med 9:677-80. 2008
    ..Host genetic factors implicated in AIDS dementia complex (ADC) were studied...
  28. pmc HIV-1 Nef inhibits lipopolysaccharide-induced IL-12p40 expression by inhibiting JNK-activated NFkappaB in human monocytic cells
    Wei Ma
    Department of Pathology, Research Institute, Children s Hospital of Eastern Ontario, Ottawa, Ontario K1H 8L1, Canada
    J Biol Chem 284:7578-87. 2009
    ..Overall, our results suggest for the first time that intracellular nef inhibited LPS-activated JNK, which may cause inhibition of IL-12p40 expression in human monocytic cells by selectively inhibiting NFkappaB activity...
  29. ncbi Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5
    D Sieburth
    Genetic Institute, Cambridge, Massachusetts 02140
    Genomics 14:59-62. 1992
    ..The subunits map to different chromosomes: p40 (IL12B) to 5q31-q33 and p35 (IL12A) to 3p12-3q13.2.
  30. ncbi IL-12p40 is associated with type 1 diabetes in Caucasian-American families
    Abdoreza Davoodi-Semiromi
    Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, Florida, USA
    Diabetes 51:2334-6. 2002
    ..These results provide genetic and functional evidence for IL-12p40 as a type 1 diabetes susceptibility gene...
  31. pmc The IL12B gene is associated with asthma
    Adrienne G Randolph
    Channing Laboratory, Brigham and Women s Hospital, Department of Anesthesia, Children s Hospital, and Harvard Medical School, Boston, MA, USA
    Am J Hum Genet 75:709-15. 2004
    The IL12B gene on chromosome 5q31-33 encodes the p40 subunit of interleukin 12, an immunomodulatory cytokine...
  32. ncbi Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis
    Francesca Capon
    Department of Medical and Molecular Genetics, Division of Genetics and Molecular Medicine, King s College, London, UK
    Hum Genet 122:201-6. 2007
    ..00014. Next, we examined genetic variation at the IL12RB1, IL23A and IL12B genes, respectively, encoding the second subunit of the IL23R receptor and the two subunits of its ligand...
  33. ncbi Variants in the 5q31 cytokine gene cluster are associated with psoriasis
    M Chang
    Celera, Alameda, CA 94502, USA
    Genes Immun 9:176-81. 2008
    ..74; P(comb)=7.05E-04). In combination with the other known genetic risk factors, HLA-C, IL12B and IL23R, the variants reported here generate an 11-fold psoriasis-risk differential...
  34. pmc The inflammatory disease-associated variants in IL12B and IL23R are not associated with rheumatoid arthritis
    Monica Chang
    Celera, Alameda, CA, USA
    Arthritis Rheum 58:1877-81. 2008
  35. pmc The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells
    X Ma
    Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104, USA
    J Exp Med 183:147-57. 1996
    ..Two other elements, IRF-1 located at -730 to -719, and NF-IL6 at -520 to -512, were also studied by deletion analysis, which did not result in decreased response to IFN-gamma and LPS stimulation...
  36. pmc Interleukin 12B (IL12B) genetic variation and pulmonary tuberculosis: a study of cohorts from The Gambia, Guinea-Bissau, United States and Argentina
    Gerard A J Morris
    MRC Laboratories, Fajara, The Gambia West Africa
    PLoS ONE 6:e16656. 2011
    We examined whether polymorphisms in interleukin-12B (IL12B) associate with susceptibility to pulmonary tuberculosis (PTB) in two West African populations (from The Gambia and Guinea-Bissau) and in two independent populations from North ..
  37. ncbi Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells
    S F Wolf
    Genetics Institute, Inc, Cambridge, MA 02140
    J Immunol 146:3074-81. 1991
    ..This factor, termed natural killer cell stimulatory factor (NKSF), possessed pleiotropic activities including the induction of IFN-gamma from PBL, enhancement of cytotoxicity by NK ..
  38. pmc Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor
    U Gubler
    Department of Molecular Genetics, Roche Research Center, Hoffmann La Roche, Inc, Nutley, NJ 07110
    Proc Natl Acad Sci U S A 88:4143-7. 1991
    Cytotoxic lymphocyte maturation factor (CLMF) is a disulfide-bonded heterodimeric lymphokine that (i) acts as a growth factor for activated T cells independent of interleukin 2 and (ii) synergizes with suboptimal concentrations of ..
  39. ncbi Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity
    P Ling
    Department of Inflammation Autoimmune Diseases, Hoffmann La Roche, Inc, Nutley, NJ 07110
    J Immunol 154:116-27. 1995
    ..When p40 is associated with a p35 subunit, the heterodimer acts as an agonist mediating biologic activity. However, when p40 associates with another p40, the homodimer behaves as an antagonist in vitro...
  40. pmc Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor alpha production
    A D'ANDREA
    Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104
    J Exp Med 181:537-46. 1995
    ..These results suggest an unexpected complexity in the regulatory role of IL-4 and IL-13 in immune responses...
  41. ncbi Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist
    S Gillessen
    Department of Inflammation Autoimmune Diseases, Hoffmann La Roche Inc, Nutley, NJ 07110
    Eur J Immunol 25:200-6. 1995
    ..Further studies are required to determine whether or not (p40)2 is produced by normal lymphoid cells and is a physiologic regulator of IL-12 activity...
  42. ncbi Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency
    F Altare
    INSERM U429, Hopital Necker Enfants Malades, Paris 75015, France
    Science 280:1432-5. 1998
    ..Thus, IL-12-dependent IFN-gamma secretion in humans seems essential in the control of mycobacterial infections, despite the formation of mature granulomas due to IL-12-independent IFN-gamma secretion...
  43. ncbi Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
    B Oppmann
    DNAX Research Institute, Palo Alto, CA 94304, USA
    Immunity 13:715-25. 2000
    ..Similar to IL-12, human IL-23 stimulates IFN-gamma production and proliferation in PHA blast T cells, as well as in CD45RO (memory) T cells...
  44. ncbi Genetic polymorphism of IL-12 p40 gene in immune-mediated disease
    M A Hall
    Department of Rheumatology, Division of Medicine, 5th Floor Thomas Guy House, Guy s, King s and St Thomas Hospitals School of Medicine, King s College, Guy s Hospital Campus, London SE1 9RT, UK
    Genes Immun 1:219-24. 2000
    ..02 95% CI 0.95-4.3). This new genetic marker could be useful in anthropological studies and should be investigated in other autoimmune, allergic, inflammatory and infectious diseases...
  45. ncbi Complete primary structure, chromosomal localisation, and definition of polymorphisms of the gene encoding the human interleukin-12 p40 subunit
    D Huang
    Complex Genetic Diseases Laboratory, and Cooperative Research Centre for Discovery of Genes for Common Human Diseases, Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria 3050, Australia
    Genes Immun 1:515-20. 2000
    ..This finding places constraints on any preferential involvement of alleles of IL-12p40 in contributing to autoimmune, inflammatory or infectious diseases...
  46. ncbi Native HIV-1 Tat protein targets monocyte-derived dendritic cells and enhances their maturation, function, and antigen-specific T cell responses
    Emanuele Fanales-Belasio
    Laboratory of Virology, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    J Immunol 168:197-206. 2002
    ..Thus, Tat can act as both Ag and adjuvant, capable of driving T cell-mediated immune responses...
  47. pmc Inherited interleukin-12 deficiency: IL12B genotype and clinical phenotype of 13 patients from six kindreds
    Capucine Picard
    Laboratoire de Genetique Humaine des Maladies Infectieuses, Université René Descartes INSERM U550, Faculte de Medecine Necker, Paris, France
    Am J Hum Genet 70:336-48. 2002
    ..It consists of two subunits, p35 and p40, which are encoded by IL12A and IL12B, respectively...
  48. ncbi A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R
    Christi Parham
    Department of Immunology, DNAX Research, Palo Alto, CA 94304, USA
    J Immunol 168:5699-708. 2002
    ..The ability of cells to respond to IL-23 or IL-12 correlates with expression of IL-23R or IL-12Rbeta2, respectively. The human IL-23R gene is on human chromosome 1 within 150 kb of IL-12Rbeta2...
  49. ncbi Association of IL12B promoter polymorphism with severity of atopic and non-atopic asthma in children
    Grant Morahan
    The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria 3050, Australia
    Lancet 360:455-9. 2002
    ..There is no genetic explanation for how hyper-responsiveness to these disparate environmental stimuli develops among individuals with asthma. Our aim was to assess relation between an IL12B promoter polymorphism and asthma.
  50. ncbi Interleukin-12 p40 gene (IL12B) 3'-untranslated region polymorphism is associated with susceptibility to atopic dermatitis and psoriasis vulgaris
    Yuichiro Tsunemi
    Department of Dermatology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Dermatol Sci 30:161-6. 2002
    ..The IL-12 p40 subunit gene (IL12B) is located at chromosome 5q31-33 and linkage findings of AD on 5q31 were reported...
  51. ncbi Regulation of virus-induced IL-12 and IL-23 expression in human macrophages
    Jaana Pirhonen
    Department of Microbiology, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    J Immunol 169:5673-8. 2002
    ..IFN-gamma, in contrast, up-regulates the p19 and p40 mRNA expression in Sendai virus infection. Thus, IL-4 and IFN-gamma serve as opposing factors in the regulation of IFN-gamma-inducing cytokines, including IL-23, in macrophages...
  52. ncbi A TaqI polymorphism in the 3'UTR of the IL-12 p40 gene correlates with increased IL-12 secretion
    D Seegers
    The Mucosal Immunity Section, National Institutes of Health, Bethesda, MD, USA
    Genes Immun 3:419-23. 2002
    ..While this polymorphism does not appear to be correlated with susceptibility to CD in the limited population of patients tested here, it could influence the occurrence of the disease in certain subsets of patients...
  53. ncbi Association between IFNA genotype and the risk of sarcoidosis
    Mitsuteru Akahoshi
    Laboratory for Genetics of Allergic Diseases, SNP Research Center, Institute of Physical and Chemical Research, RIKEN Yokohama Institute, Yokohama, Japan
    Hum Genet 114:503-9. 2004
    ..polymorphisms within 10 candidate genes involved in type 1 immune process ( IFNA17, IFNB, IFNG, IFNGR1, IFNGR2, IL12B, IL12RB1, IL12RB2, ETA-1, and NRAMP1) in an association-based study of 102 Japanese patients with sarcoidosis, 114 ..
  54. ncbi HLA and cytokine gene polymorphisms are independently associated with responses to hepatitis B vaccination
    Chengbin Wang
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Hepatology 39:978-88. 2004
    ..with single nucleotide polymorphisms (SNPs) at the IL2 and IL4 loci along with insertion/deletion variants at the IL12B locus (P =.003-.01)...
  55. ncbi Associations between IL12B polymorphisms and tuberculosis in the Hong Kong Chinese population
    Hoi W Tso
    Department of Pediatrics and Adolescent Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region, China
    J Infect Dis 190:913-9. 2004
    ..Interleukin (IL)-12 plays a vital role in regulating cell-mediated immunity against tuberculosis (TB)...
  56. ncbi Definition of polymorphisms and haplotypes in the interleukin-12B gene: association with IL-12 production but not with Crohn's disease
    A Zwiers
    Laboratory of Immunogenetics, Vrije Universiteit Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Genes Immun 5:675-7. 2004
    ..Recently, functional polymorphisms in IL-12p40 (IL12B) were found to be associated with susceptibility to several autoimmune diseases...
  57. ncbi Alleles of the IL12B 3'UTR associate with late onset of type 1 diabetes
    Lydia Windsor
    School of Surgery and Pathology, University of Western Australia Nedlands, Australia
    Hum Immunol 65:1432-6. 2004
    Carriage of a polymorphism in the 3'untranslated region of the IL12B gene encoding IL-12p40 was investigated in subjects with type 1 diabetes mellitus stratified by age at diagnosis (n = 648) and compared with a population-based control ..
  58. ncbi Taq-I polymorphism in 3'UTR of the IL-12B and association with IL-12p40 production from human PBMC
    S Stanilova
    Department of Molecular Biology, Immunology and Genetics, Faculty of Medicine, Trakia University, Stara Zagora, Bulgaria
    Genes Immun 6:364-6. 2005
    ....
  59. ncbi Association between the 1188 A/C polymorphism in the human IL12B gene and Th1-mediated infectious diseases
    M B Freidin
    Int J Immunogenet 33:231-2. 2006
  60. pmc A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes
    Michele Cargill
    Celera, Alameda, CA 94502, USA
    Am J Hum Genet 80:273-90. 2007
    ..with 25,215 genecentric single-nucleotide polymorphisms (SNPs) and found a highly significant association with an IL12B 3'-untranslated-region SNP (rs3212227), confirming the results of a small Japanese study...
  61. ncbi Association of polymorphisms in IL-12/IFN-gamma pathway genes with susceptibility to pulmonary tuberculosis in Indonesia
    Edhyana Sahiratmadja
    Eijkman Institute for Molecular Biology, Jakarta, Indonesia
    Tuberculosis (Edinb) 87:303-11. 2007
    ..We analyzed the distribution of polymorphisms in four essential genes from the IL-12/IFN-gamma axis, IL12B, IL12RB1, IFNG and IFNGR1, in 382 pulmonary tuberculosis patients and 437 healthy controls from an endemic region ..
  62. ncbi Association of variants in the IL12B gene with leprosy and tuberculosis
    G Morahan
    Diabetes Research Centre, Western Australia Institute for Medical Research, Perth, WA, Australia
    Tissue Antigens 69:234-6. 2007
    ..One of the key cytokine regulators of the immune response is interleukin (IL-) 12. The IL12B gene encodes the p40 chain of both IL-12 and IL-23 and it has two major variant sites at which different alleles ..
  63. pmc Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility
    Miles Parkes
    Inflammatory Bowel Disease Research Group, Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 2QQ, UK
    Nat Genet 39:830-2. 2007
    ..We obtained replication for the autophagy-inducing IRGM gene on chromosome 5q33.1 (replication P = 6.6 x 10(-4), combined P = 2.1 x 10(-10)) and for nine other loci, including NKX2-3, PTPN2 and gene deserts on chromosomes 1q and 5p13...
  64. ncbi Polymorphism in the 3' UTR of the IL12B gene is associated with Chagas' disease cardiomyopathy
    German Zafra
    Grupo de Inmunología y Epidemiología Molecular, GIEM, Facultad de Salud, Universidad Industrial de Santander, Carrera 32 29 31, Bucaramanga AA 678, Colombia
    Microbes Infect 9:1049-52. 2007
    ..of this study was to investigate the possible influence of a 3' untranslated region (3' UTR) polymorphism of the IL12B gene in susceptibility to Trypanosoma cruzi infection or in the development to cardiomyopathy in Chagas' disease (..
  65. ncbi Interleukin-12B & interleukin-10 gene polymorphisms in pulmonary tuberculosis
    S Prabhu Anand
    Tuberculosis Research Centre ICMR, Chennai, India
    Indian J Med Res 126:135-8. 2007
    ..The aim of this study was to know whether Interleukin-12B 3' UTR (Taq1) (A/C) and Interleukin-10 (-1082 G/A) gene polymorphisms were associated with susceptibility to pulmonary tuberculosis...
  66. pmc Increased circulating interleukin (IL)-23 in children with malarial anemia: in vivo and in vitro relationship with co-regulatory cytokines IL-12 and IL-10
    John M Ong'echa
    University of Pittsburgh KEMRI Laboratories of Parasitic and Viral Diseases, Centre for Vector Biology and Control Research, Kenya Medical Research Institute, Kisumu, Kenya
    Clin Immunol 126:211-21. 2008
    ..Taken together, results here show that IL-23 is elevated in children with malarial anemia, and that IL-10 and IL-12 appear to have important regulatory effects on IL-23 production during childhood malaria...
  67. ncbi Polymorphisms in the IL-12beta and IL-23R genes are associated with psoriasis of early onset in a UK cohort
    Rhodri L L Smith
    J Invest Dermatol 128:1325-7. 2008
  68. ncbi The autoimmune disease-associated IL12B and IL23R polymorphisms in multiple sclerosis
    Ann B Begovich
    Celera, Alameda, CA, USA
    Hum Immunol 68:934-7. 2007
    ..in psoriasis, inflammatory bowel disease, and ankylosing spondylitis identified significant associations with IL12B and IL23R polymorphisms...
  69. pmc Polymorphisms of the IL12B and IL23R genes are associated with psoriasis
    Rajan P Nair
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0932, USA
    J Invest Dermatol 128:1653-61. 2008
    ..A recent study reported that psoriasis was associated with the IL12B haplotype rs3212227 (3'-untranslated region)-rs6887695 (60 kb, 5') and the IL23R haplotype rs7530511 (L310P)-..
  70. doi A role for interleukin-12/23 in the maturation of human natural killer and CD56+ T cells in vivo
    Sophie Guia
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Marseille, France
    Blood 111:5008-16. 2008
    ....
  71. pmc A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci
    Ying Liu
    Division of Human Genetics, Department of Genetics, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Genet 4:e1000041. 2008
    ..We replicated the previously reported association with interleukin 23 receptor and interleukin 12B (IL12B) polymorphisms in PS and PSA cohorts (IL23R: rs11209026, U.S. PS, P = 1.4x10(-4); U.K. PSA: P = 8...
  72. doi IL23R and IL12B polymorphisms in Spanish IBD patients: no evidence of interaction
    Ana Marquez
    Clinical Immunology Department, Hospital Clinico San Carlos, Madrid, Spain
    Inflamm Bowel Dis 14:1192-6. 2008
    Recent genomic surveys have identified IL23R and IL12B as susceptibility loci for inflammatory bowel disease (IBD)...
  73. doi A functional promoter variant in IL12B predisposes to cerebral malaria
    Sandrine Marquet
    INSERM, UMR906, Genetics and Immunology of Parasitic Diseases, Marseille F 13005, France
    Hum Mol Genet 17:2190-5. 2008
    ..We investigated 21 markers in IL12-related genes, including IL12A and IL12B encoding the two IL-12 (IL12p70) subunits, IL12p35 and IL12p40...
  74. doi IL12B polymorphisms are linked but not associated with Plasmodium falciparum parasitemia: a familial study in Burkina Faso
    M Barbier
    Aix Marseille Universite, IFR 48, Faculte de Pharmacie, Laboratoire de Pharmacogénétique des Maladies Parasitaires, Marseille, France
    Genes Immun 9:405-11. 2008
    ..This chromosomal region contains numerous immunoregulatory genes. Among these, IL12B that encodes the p40 subunit of interleukin-12 (IL-12) appeared to be a promising functional candidate gene, and ..
  75. doi The 3'UTR 1188 A/C polymorphism in the interleukin-12p40 gene (IL-12B) is associated with lepromatous leprosy in the west of Mexico
    Anabell Alvarado-Navarro
    Centro de Investigacion en Inmunologia y Dermatologia, Departamento de Fisiologia, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico
    Immunol Lett 118:148-51. 2008
    ..These data suggest that IL-12 p40 3'UTR 1188 A/C polymorphism is associated with greater susceptibility to lepromatous leprosy in patients from western Mexico, independently of IL-12 p40 and p70 expression levels...
  76. doi Genetic variants of the IL-23R pathway: association with psoriatic arthritis and psoriasis vulgaris, but no specific risk factor for arthritis
    Ulrike Huffmeier
    Institute of Human Genetics, University Hospital Erlangen, University Erlangen Nuremberg, Erlangen, Germany
    J Invest Dermatol 129:355-8. 2009
    ..Four variants of the IL12B and IL23R genes were analyzed in 1,114 PV patients, 748 patients with psoriatic arthritis (PA) and 937 healthy ..
  77. pmc Investigation of association of the IL12B and IL23R genes with psoriatic arthritis
    Charlotte Filer
    University of Manchester, Manchester, UK
    Arthritis Rheum 58:3705-9. 2008
    ..The aim of this study was to determine whether these variants are also associated with susceptibility to psoriatic arthritis (PsA)...
  78. doi IL-23 modulates CD56+/CD3- NK cell and CD56+/CD3+ NK-like T cell function differentially from IL-12
    Diederik van de Wetering
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Int Immunol 21:145-53. 2009
    ....
  79. doi Interactions of IL-12A and IL-12B polymorphisms on the risk of cervical cancer in Chinese women
    Xiaojun Chen
    Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China
    Clin Cancer Res 15:400-5. 2009
    ..We hypothesized that potentially functional polymorphisms in IL12A and IL12B may individually and jointly contribute to cervical cancer risk.
  80. pmc Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways
    Rajan P Nair
    Department of Dermatology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nat Genet 41:199-204. 2009
    ..Loci with confirmed association include HLA-C, three genes involved in IL-23 signaling (IL23A, IL23R, IL12B), two genes that act downstream of TNF-alpha and regulate NF-kappaB signaling (TNIP1, TNFAIP3) and two genes ..
  81. pmc Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease
    Kai Wang
    Center for Applied Genomics, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Am J Hum Genet 84:399-405. 2009
    ..Interestingly, the pathway contains multiple genes (IL12B and JAK2) or homologs of genes (STAT3 and CCR6) that were recently identified as genuine susceptibility genes only ..
  82. doi Serum levels of interleukin-10 and interleukin-12 predict early, spontaneous hepatitis B virus e antigen seroconversion
    Jia Feng Wu
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    Gastroenterology 138:165-72.e1-3. 2010
    ..This prospective cohort study aimed to determine the effect of cytokines on spontaneous hepatitis B e antigen (HBeAg) seroconversion in patients with chronic hepatitis B virus (HBV) infection...
  83. doi Genetic analysis in a Dutch study sample identifies more ulcerative colitis susceptibility loci and shows their additive role in disease risk
    Eleonora A M Festen
    Department of Gastroenterology and Hepatology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    Am J Gastroenterol 105:395-402. 2010
    ..Genetic susceptibility is known to make a major contribution to the pathogenesis of ulcerative colitis (UC). Recently, three studies, including a genome-wide association study (GWAS), reported novel UC risk loci...
  84. ncbi Allelic polymorphism of cytokine genes during pulmonary tuberculosis
    I O Naslednikova
    Department of Pathophysiology, Department of Phthisiology and Pulmonology, Siberian State Medical University, Federal Agency of Health Care and Social Development, Tomsk, Russia
    Bull Exp Biol Med 148:175-80. 2009
    ..T allele and TT genotype of C-590T polymorphism in the IL4 gene, and CC genotype of A-1188C polymorphism in the IL12B gene are immunogenetic factors that have protective activity against susceptibility to pulmonary tuberculosis...
  85. doi Association of single nucleotide polymorphisms in the IL-12 (IL-12A and B) and IL-12 receptor (IL-12Rbeta1 and beta2) genes and gene-gene interactions with atopic dermatitis in Koreans
    Jung Hyun Namkung
    Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon Dong, Gangnam Gu, Seoul 135 710, South Korea
    J Dermatol Sci 57:199-206. 2010
    ..The acute skin lesions of atopic dermatitis (AD) are associated with Th2 cells; however, the chronic skin lesions of AD are associated with Th1 cells via the action of IL-12...
  86. pmc Polymorphisms in genes of interleukin 12 and its receptors and their association with protection against severe malarial anaemia in children in western Kenya
    Lyna Zhang
    Malaria Branch, Division of Parasitic Diseases, National Center for Zoonotic, Vector Borne and Enteric Diseases, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Malar J 9:87. 2010
    ..Based on the biological relevance of IL12 in malaria anaemia, the relationship between genetic polymorphisms of IL12 and its receptors and SMA was examined...
  87. pmc Haplotypes of IL12B promoter polymorphisms condition susceptibility to severe malaria and functional changes in cytokine levels in Thai adults
    Chintana Phawong
    Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok, 10400, Thailand
    Immunogenetics 62:345-56. 2010
    Polymorphic variability in immune response genes, such as IL12B, encoding the IL-12p40 subunit is associated with susceptibility to severe malaria in African populations...
  88. doi IL12 polymorphisms, HBV infection and risk of hepatocellular carcinoma in a high-risk Chinese population
    Li Liu
    Department of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, Nanjing, China
    Int J Cancer 128:1692-6. 2011
    To investigate the association between the potentially functional polymorphisms in IL12A and IL12B, HBV infection and risk of hepatocellular carcinoma in a Chinese population, we genotyped three polymorphisms, rs568408 (3'UTR G>A), ..
  89. pmc Analysis of eight genes modulating interferon gamma and human genetic susceptibility to tuberculosis: a case-control association study
    Marlo Möller
    Molecular Biology and Human Genetics, MRC Centre for Molecular and Cellular Biology, Faculty of Health Sciences, PO Box 19063, Stellenbosch University, Tygerberg 7505, South Africa
    BMC Infect Dis 10:154. 2010
    ..tuberculosis. Based on the hypothesis that genes which regulate interferon gamma may influence tuberculosis susceptibility, we investigated polymorphisms in eight candidate genes...
  90. pmc A polymorphism in the coding region of Il12b promotes IL-12p70 and IL-23 heterodimer formation
    Antonie Zwiers
    Department of Gastroenterology and Hepatology, Vrije Universiteit Medical Center, 1007 MB Amsterdam, The Netherlands
    J Immunol 186:3572-80. 2011
    ..In this study, we investigated how polymorphisms in the coding region of murine Il12b influence IL-12 and IL-23 heterodimer formation...
  91. pmc Polymorphic variability in the 3' untranslated region (UTR) of IL12B is associated with susceptibility to severe anaemia in Kenyan children with acute Plasmodium falciparum malaria
    John M Ong'echa
    Centre for Global Health Research, University of New Mexico Laboratories of Parasitic and Viral Diseases, Kenya Medical Research Institute, Kisumu, Kenya
    BMC Genet 12:69. 2011
    ..Since the role of IL12B variants in conditioning susceptibility to SMA remains largely unexplored, the association between a single ..
  92. doi Association of IL-12B genetic polymorphism with the susceptibility and disease severity of ankylosing spondylitis
    Ruey Hong Wong
    Institute of Medicine, Chung Shan Medical University, No 110 Chien Kuo N Road, Section 1, Taichung 40201, Taiwan
    J Rheumatol 39:135-40. 2012
    ..IL-12B encodes a p40 subunit common to IL-12 and IL-23. We evaluated the effects of IL-12B and IL-23R genotype on the occurrence and clinical features of AS...
  93. doi Single nucleotide polymorphism in the interleukin 12B gene is associated with risk for breast cancer development
    M H Kaarvatn
    Molecular Genetics Laboratory, Department of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway
    Scand J Immunol 76:329-35. 2012
    We analysed the association of a single nucleotide polymorphism (SNP) in the gene encoding the IL-12 subunit p40 (IL12B, rs3212227, A>C) with breast cancer...
  94. doi Associations between polymorphisms in IL-12A, IL-12B, IL-12Rβ1, IL-27 gene and serum levels of IL-12p40, IL-27p28 with esophageal cancer
    Yi Peng Tao
    Department of Thoracic Surgery, First Affiliated Hospital of Xinxiang Medical University, Weihui City, 453100 Henan Province, People s Republic of China
    J Cancer Res Clin Oncol 138:1891-900. 2012
    ..The aim of this study was to investigate whether IL-12A, IL-12B, IL-12Rβ1, and IL-27 gene polymorphisms and serum levels of IL-12, IL-27 are associated with esophageal cancer...
  95. pmc Susceptibility-associated genetic variation at IL12B enhances Th1 polarization in psoriasis
    Andrew Johnston
    Department of Dermatology, University of Michigan, Ann Arbor, MI 48109, USA
    Hum Mol Genet 22:1807-15. 2013
    The IL12B gene encodes the common p40 subunit of IL-12 and IL-23, cytokines with key roles in Th1 and Th17 biology, respectively, and genetic variation in this region significantly influences risk of psoriasis...
  96. doi IL12B and IL23R gene SNPs in Japanese psoriasis
    Akira Oka
    The Institute of Medical Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259 1193, Japan
    Immunogenetics 65:823-8. 2013
    ..The IL12B gene, which encodes the shared IL-12p40 subunit in two cytokines, IL-12 and IL-23, and the IL23R gene, which ..
  97. doi Association of interleukin-12 polymorphisms and serum IL-12p40 levels with osteosarcoma risk
    Junli Wang
    1 Center of Clinical Laboratory, Affiliated Hospital of Youjiang Medical College for Nationalities, Baise, China
    DNA Cell Biol 32:605-10. 2013
    ..Our data suggest that the serum IL-12p40 levels associate with the risk of osteosarcoma and are regulated by IL-12B rs3212227 polymorphism. The IL-12A rs568408 and IL-12B rs3212227 may confer the susceptibility to osteosarcoma risk. ..
  98. pmc Local production of the p40 subunit of interleukin 12 suppresses T-helper 1-mediated immune responses and prevents allogeneic myoblast rejection
    K Kato
    Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
    Proc Natl Acad Sci U S A 93:9085-9. 1996
    ..Therefore, IL-12p40 gene transduction would be useful for preventing the rejection of allografts and genetically modified own cells that are transduced with potentially antigenic molecules in gene therapy...
  99. ncbi Involvement of dihydropyridine-sensitive calcium channels in human dendritic cell function. Competition by HIV-1 Tat
    A Poggi
    Laboratory of Immunopathology, National Institute for Cancer Research and Advanced Biotechnology Center, Genoa 16132, Italy
    J Biol Chem 273:7205-9. 1998
    ..Taken together, these findings indicate that exogenous Tat exerts its inhibitory effects on dendritic cells by blocking dihydropyridine-sensitive L-type calcium channels...
  100. pmc Role of Toll-like receptor 9 in Legionella pneumophila-induced interleukin-12 p40 production in bone marrow-derived dendritic cells and macrophages from permissive and nonpermissive mice
    Cathy A Newton
    Department of Molecular Medicine, MDC Box 10, University of South Florida College of Medicine, 12901 Bruce B Downs Boulevard, Tampa, FL 33612, USA
    Infect Immun 75:146-51. 2007
    ....
  101. pmc A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes
    O Devergne
    Department of Microbiology and Molecular Genetics, Harvard University, Boston, Massachusetts, USA
    J Virol 70:1143-53. 1996
    ..EBI3 synthesis by trophoblasts and by EBV-transformed cells and similarities to interleukin-12 p40 are compatible with a role for EBI3 in regulating cell-mediated immune responses...

Research Grants35

  1. JAMES TILFORD ELDER; Fiscal Year: 2016
    ..association signal distinct from HLA-Cw6 as well as genome- wide significance for multiple non-MHC loci including IL12B, TNFAIP3, TNIP1, and TYK2, and TRAF3IP2 ...
  2. Jean Laurent Casanova; Fiscal Year: 2016
    ..MSMD over the last fifteen years has identified six morbid genes, including five autosomal (IFNGR1, IFNGR2, STAT1, IL12B, IL12RB1) and one X- linked (NEMO) gene...
  3. Jean Laurent Casanova; Fiscal Year: 2014
    ..of MSMD over the last 15 years has identified six morbid genes, including five autosomal (IFNGR1, IFNGR2, STAT1, IL12B, IL12RB1) and one X-linked (NEMO) gene...
  4. Immunogenetics of Cervical Cancer A Family-Based Design
    Stephen Schwartz; Fiscal Year: 2005
    ..We hypothesize that variation in the genes encoding the cytokines IL10 and IL12 (IL10, IL12A and IL12B) is associated with invasive cervical cancer risk in women persistently infected with HPV...
  5. JAMES TILFORD ELDER; Fiscal Year: 2016
    ..Of these loci, three confirm previous reports of association (at HLA-C, IL12B, IL23R) and four identify novel signals located near plausible candidate genes (IL23A, IL13, TNFAIP3, and TNIP1)...
  6. Identification of Psoriatic Arthritis Genes
    JAMES TILFORD ELDER; Fiscal Year: 2013
    ..scanning the rest of the genome for PsA loci, we assessed the top 7 confirmed associations from CASP (HLA-C, IL12B, TNIP1, IL13, TNFAIP3, IL23A, and IL23R) in 1,755 PsA cases vs...
  7. Lionel B Ivashkiv; Fiscal Year: 2016
    ..genes important for host defense against intracellular pathogens and Th1 responses: Il12a (encoding IL-12 p35), Il12b (p40) and Nos2 (iNOS). Expression of these genes is regulated by IRF1, IRF8 and the NF-?B family member c-Rel...
  8. Genotyping the NPF Biobank for Psoriasis Susceptibility Genes
    JAMES TILFORD ELDER; Fiscal Year: 2010
    ..The loci with confirmed association encode HLA-C, three genes involved in IL-23 signaling (IL23A, IL23R and IL12B), two genes that act downstream of TNF-[unreadable] and regulate NF-[unreadable]B signaling (TNIP1 and TNFAIP3), ..
  9. Pioneer factor interactions in embryonic stem cells
    Stephen T Smale; Fiscal Year: 2010
    ..hypothesis, we recently demonstrated that well-characterized enhancers for three tissue-specific genes, Ptcra, Il12b, and Alb1, are selectively marked by unmethylated CpG dinucleotides in pluripotent ES cells...
  10. IMMUNOGENETIC MECHANISMS OF VACCINE RESPONSE
    Gregory A Poland; Fiscal Year: 2010
    ..The knowledge gained from these studies will enable us to design new strategies and new vaccines to protect human health against viral diseases. ..
  11. Organ Culture of Basal Cell Carcinoma
    James Elder; Fiscal Year: 2002
    ....
  12. Amphiregulin in Psoriatic Epidermal Hyperplasia
    JAMES TILFORD ELDER; Fiscal Year: 2010
    ..If successful, this research will have important public health consequences not only in psoriasis but also in a wide variety of dermatoses characterized by epidermal hyperplasia. ..
  13. Genome-wide association of common alleles with long-term diabetic complications
    Andrew Paterson; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  14. The Natural History of Pediatric Crohn's Disease
    Marla Dubinsky; Fiscal Year: 2008
    ..abstract_text> ..
  15. Mapping Chromosome 3q Inflammatory Bowel Disease Genes
    JUDY CHO; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  16. Parental Expression of Immune Responses In Pediatric Crohn's Disease
    Marla Dubinsky; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  17. Host Genetic Factors in the HIV Virus Life-Cycle and HIV Disease Progression
    Jairam Lingappa; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  18. Molecular Epidemiology of non-Hodgkin Lymphoma Survival
    James R Cerhan; Fiscal Year: 2010
    ..Host genetics may also lead to a better understanding of NHL pathophysiology that could lead to new approaches to improve the survival of NHL patients. ..
  19. MOLECULAR MODELING OF DIAGNOSIS AND PROGNOSIS IN HNSCC
    Maria Worsham; Fiscal Year: 2009
    ..abstract_text> ..
  20. Adenosine in trauma and sepsis
    Gyorgy Hasko; Fiscal Year: 2007
    ..abstract_text> ..
  21. IL-12-Faciliated Hematopoietic Recovery Following Myeloablative Therapy
    Dan Douer; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  22. Immunogenetics of Non-Hodgkin Lymphoma Survival
    James Cerhan; Fiscal Year: 2006
    ..abstract_text> ..
  23. Spondyloarthritis 2006; The Unmet Needs
    John Reveille; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  24. Arsenic Trioxide and Vitamin C in AML
    Dan Douer; Fiscal Year: 2005
    ..In summary, this combination may have higher benefit/risk ratio in non-APL AML patients resulting in an overall better outcome with less toxicity than conventional chemotherapy. ..
  25. IMMUNOTOXICOLOGY OF A HEAVY METAL
    Kenneth Pollard; Fiscal Year: 2004
    ..Analysis of the interaction between fibrillarin, mercury and cells of the lymphoid system may lead to insights into how an imunotoxin renders self-antigen immunogenic. ..
  26. Large Scale Images of Gene Transcription in MS and EAE
    Lawrence Steinman; Fiscal Year: 2004
    ..The discovery of the role of osteopontin, first identified in large scale profiles, exemplifies how this approach may help us to understand MS and to develop new therapies. ..
  27. IDENTIFYING MAJOR SUSCEPTIBILITY GENES OF IBD
    JUDY CHO; Fiscal Year: 2003
    ..Once risk alleles are identified in multiplex families, characterization of the nature and broad significance of specific risk alleles for IBD in a variety of populations will be performed. ..
  28. FAMILY STUDIES OF THE GENETICS OF ANKYLOSING SPONDYLITIS
    John Reveille; Fiscal Year: 2003
    ..abstract_text> ..
  29. IN VIVO TREATMENT OF EAE WITH ANTI I-A ANTIBODIES
    Lawrence Steinman; Fiscal Year: 2001
    ..Aim 5 is to assess the possibility of using DNA vaccination against TCR Vb for treatment of EAE. It is hoped that these studies will provide the basis for future clinical trials in MS patients. ..
  30. BECTON DICKINSON FACS CALIBUR 4 COLOR WITH SORT UNIT
    Kenneth Pollard; Fiscal Year: 2001
    ..Flow cytometry will be used to select and sort cell populations prior to and after transplantation studies. ..
  31. MERCURY INDUCED AUTOIMMUNITY
    Kenneth Pollard; Fiscal Year: 2007
    ..Identification of the role that IFN-gamma plays in the development of induced murine systemic autoimmunity should prove applicable to murine models of idiopathic systemic autoimmunity and to human lupus. ..
  32. XENOBIOTIC ACCELERATION OF AUTOIMMUNITY
    Kenneth Pollard; Fiscal Year: 2003
    ..abstract_text> ..
  33. PEPTIDE MEDIATED IMMUNOTHERAPY FOR AUTOIMMUNE DISEASE
    Lawrence Steinman; Fiscal Year: 2003
    ..This work with APL may be applicable not only to MS, but to other autoimmune diseases including juvenile diabetes, rheumatoid arthritis, and inflammatory bowel disease. ..
  34. CANNABINOID RECEPTORS ON IMMUNE CELLS
    Thomas Klein; Fiscal Year: 2003
    ..The experiments proposed will increase our understanding of the imnunobiology of the cannabinoid system and shed light on the health consequences of medicinal marijuana use in HIV disease. ..
  35. BENIGN BREAST DISEASE--MOLECULAR DIFFERENTIATION OF RISK
    Maria Worsham; Fiscal Year: 2001
    ....