Genomes and Genes
Gene Symbol: IL12B
Description: interleukin 12B
Alias: CLMF, CLMF2, IL-12B, IMD28, IMD29, NKSF, NKSF2, interleukin-12 subunit beta, CLMF p40, IL-12 subunit p40, IL12, subunit p40, NK cell stimulatory factor chain 2, cytotoxic lymphocyte maturation factor 40 kDa subunit, interleukin 12, p40, interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40), interleukin-12 beta chain, natural killer cell stimulatory factor, 40 kD subunit
Publications232 found, 100 shown here
- Functional haplotypes of IL-12B are associated with childhood atopic asthmaTomomitsu Hirota
Laboratory for Genetics of Allergic Diseases, Single Nucleotide Polymorphism Research Center, Institute of Physical and Chemical Research RIKEN, Kanagawa, Japan
J Allergy Clin Immunol 116:789-95. 2005..Although associations between polymorphisms of IL-12B on chromosome 5q31-33 and asthma have been reported, the genetic influences of the polymorphisms and haplotype of IL-12B are unclear...
- Interleukin-12p40 gene (IL-12B) polymorphism and Type 1 diabetes mellitus in Japanese: possible role in subjects without having high-risk HLA haplotypesJian Mei Yang
Division of Endocrinology and Metabolism, Department of Medicine, Jichi Medical School, Yakushiji 3311 1, Minamikawachi, Tochigi 329 0498, Japan
Diabetes Res Clin Pract 71:164-9. 2006..The IL-12B 3'UTR A-C polymorphism would be considered as a supplementary risk factor to T1DM in conjunction with HLA haplotypes...
- Association of polymorphisms in the IL-18 and IL-12 genes with susceptibility to Type 1 diabetes in Turkish patientsA E Altinova
Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara, Turkey
J Endocrinol Invest 33:451-4. 2010..Recent studies have indicated that polymorphisms of the interleukin-18 (IL-18) and interleukin- 12 (IL-12) genes are associated with the development of Type 1 diabetes mellitus (T1DM) in some populations, but not all...
- IL12B polymorphism and type 1 diabetes in the Italian population: a case-control studyLorenza Nisticò
Institute of Cell Biology, CNR, Campus Buzzati Traverso, Monterotondo, Rome, Italy
Diabetes 51:1649-50. 2002..We analyzed the same polymorphism in 470 Italian type 1 diabetic patients and 544 matched control subjects and found no evidence of association with the disease...
- The IL12B 3' untranslated region DNA polymorphism is not associated with early-onset type 1 diabetesR M McCormack
Department of Medical Genetics, Queen s University Belfast, Belfast, Northern Ireland
Genes Immun 3:433-5. 2002..of a polymorphism (1188A allele; termed allele 1) in the 3' untranslated region (3'UTR) of the interleukin 12B (IL12B) gene which encodes the IL-12p40 subunit of the pro-inflammatory cytokine IL-12...
- Th1 cytokine polymorphisms in spanish patients with type 1 diabetesJosé L Santiago
Immunology Department, Hospital Universitario San Carlos, Madrid, Spain
Hum Immunol 66:897-902. 2005Several polymorphisms in regions where Th1 cytokines (IL12B and IFNG genes) are located were analyzed in 303 Spanish subjects with type 1 diabetes and compared with a control cohort (n = 548)...
- Differential effects of insulin-like growth factor-1 and atheroma-associated cytokines on cell proliferation and apoptosis in plaque smooth muscle cells of symptomatic and asymptomatic patients with carotid stenosisGuanghong Jia
Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
Immunol Cell Biol 84:422-9. 2006..The different expression and activity of cell cycle regulatory proteins could be responsible for apoptosis of VSMC and destabilization of atherosclerotic plaques...
- Variation in cytokine genes can contribute to severity of acetabular osteolysis and risk for revision in patients with ABG 1 total hip arthroplasty: a genetic association studyJiri Gallo
Department of Orthopaedics, Teaching Hospital and Faculty of Medicine and Dentistry, Palacky University, I P Pavlova 6, Olomouc775 20, Czech Republic Laboratory of Immunogenomics, Faculty of Medicine and Dentistry, Palacky University, I P Pavlova 6, Olomouc 775 20, Czech Republic
BMC Med Genet 10:109. 2009..This may be driven by functional polymorphisms in the genes for cytokines and cytokine receptors involved in the development of osteolysis in THA, thereby having an effect on the individual's phenotype...
- JNK1 and JNK2 differently regulate IL-12 production in THP-1 macrophage cellsMitsuyoshi Utsugi
Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
Cytokine 51:127-31. 2010....
- A stabilized HIV-1 envelope glycoprotein trimer fused to CD40 ligand targets and activates dendritic cellsMark Melchers
Laboratory of Experimental Virology, Department of Medical Microbiology Center for Infection and Immunity Amsterdam, Netherlands
Retrovirology 8:48. 2011..We have previously stabilized soluble trimeric mimics of Env by introducing a disulfide bond between gp120 and gp41 and adding a trimer stabilizing mutation in gp41 (SOSIP.R6 gp140)...
- IL-12 and GM-CSF in DNA/MVA immunizations against HIV-1 CRF12_BF Nef induced T-cell responses with an enhanced magnitude, breadth and qualityAna María Rodríguez
Centro Nacional de Referencia para el SIDA, Universidad de Buenos Aires, Buenos Aires, Argentina
PLoS ONE 7:e37801. 2012..These relevant results contribute to the design of strategies aimed to induce T-cell responses against HIV antigens with higher quality...
- IL-12 delivery from recombinant vaccinia virus attenuates the vector and enhances the cellular immune response against HIV-1 Env in a dose-dependent mannerM M Gherardi
Department of Molecular and Cellular Biology, Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Cientificas, Campus Universidad Autonoma, Madrid, Spain
J Immunol 162:6724-33. 1999..This approach can be of wide vaccination interest as a means to improve immune responses to other Ags...
- HIV-1 Nef impairs the dynamic of DC/NK crosstalk: different outcome of CD56(dim) and CD56(bright) NK cell subsetsMaria Giovanna Quaranta
Department of Drug Research and Evaluation, Istituto Superiore di Sanita, Viale Regina Elena, 299, 00161 Rome, Italy
FASEB J 21:2323-34. 2007..Our findings suggest that the Nef-induced dysregulation in the DC/NK cell crosstalk may represent a potential mechanism through which HIV escapes innate immune surveillance...
- Monocyte-derived dendritic cells from HIV type 1-infected individuals show reduced ability to stimulate T cells and have altered production of interleukin (IL)-12 and IL-10Sandrine Buisson
Department of Immunology, Faculty of Medicine, Imperial College, and Department of HIV GU Medicine, Chelsea and Westminster Hospital, London, United Kingdom
J Infect Dis 199:1862-71. 2009..Our findings suggest that MDDCs used in therapeutic vaccination of HIV-infected individuals may show reduced potency...
- Intranasal vaccination using interleukin-12 and cholera toxin subunit B as adjuvants to enhance mucosal and systemic immunity to human immunodeficiency virus type 1 glycoproteinsDiana I Albu
Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York 12208, USA
J Virol 77:5589-97. 2003....
- HIV-1 Nef triggers Vav-mediated signaling pathway leading to functional and morphological differentiation of dendritic cellsMaria Giovanna Quaranta
Department of Immunology, Istituto Superiore di Sanità Viale Regina Elena, 299 00161 Rome, Italy
FASEB J 17:2025-36. 2003..Our results highlight how Nef may enhance T lymphocyte activation, thus fostering virus dissemination, manipulating the DC arm of the immune response...
- Active cellular infection of myeloid cells is required for HIV-1-mediated suppression of interleukin-12 p40 expressionKelley A Chambers
Ottawa Health Research Institute, Ottawa, Ont, Canada
Cell Immunol 215:120-32. 2002....
- HIV-1 matrix protein p17 enhances the proliferative activity of natural killer cells and increases their ability to secrete proinflammatory cytokinesMarco Vitale
Department of Anatomy, Pharmacology and Forensic Medicine, Ospedale Maggiore, University of Parma, Italy
Br J Haematol 120:337-43. 2003..The property of p17 to increase the production of TNF-alpha and IFN-gamma might be a mechanism used by HIV-1 to modulate the immune system to support its replication and spreading...
- No evidence for association between the polymorphism in the 3' untranslated region of interleukin-12B and human susceptibility to tuberculosisXin Ma
Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
J Infect Dis 188:1116-8. 2003..Our results suggest that IL-12B 3' UTR has no effect or has a negligible effect on human susceptibility to TB...
- Mechanism of 1α,25-dihydroxyvitamin D(3)-dependent repression of interleukin-12BPetra Gynther
Department of Biosciences, University of Eastern Finland, FI 70211 Kuopio, Finland
Biochim Biophys Acta 1813:810-8. 2011..We suggest that these repressive epigenetic changes eventually cause down-regulation of IL-12 expression. This article is part of a Special Issue entitled: 11th European Symposium on Calcium...
- The immunoregulatory effects of HIV-1 Nef on dendritic cells and the pathogenesis of AIDSMaria Giovanna Quaranta
Department of Drug Research and Evaluation, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
FASEB J 20:2198-208. 2006....
- HIV-1 Tat addresses dendritic cells to induce a predominant Th1-type adaptive immune response that appears prevalent in the asymptomatic stage of infectionEmanuele Fanales-Belasio
National AIDS Center, Istituto Superiore di Sanita, Rome, Italy
J Immunol 182:2888-97. 2009....
- Differential expression of cytokine genes in HIV-1 tat transfected T and B cell linesV Sharma
Division of Hematology and Oncology, Arthur G James Cancer Hospital and Research Institute, Ohio State University, Columbus 43210
Biochem Biophys Res Commun 208:704-13. 1995....
- Induction of cytokines by HIV-1 and its gp120 protein in human peripheral blood monocyte/macrophages and modulation of cytokine response during differentiationS Gessani
Laboratory of Virology, Istituto Superiore di Sanita, Rome, Italy
J Leukoc Biol 62:49-53. 1997....
- Human immunodeficiency virus type 1 gp120 induces abnormal maturation and functional alterations of dendritic cells: a novel mechanism for AIDS pathogenesisLaura Fantuzzi
Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
J Virol 78:9763-72. 2004..The finding that gp120 induces abnormal maturation of DCs linked to profound suppression of their activities unravels a novel mechanism by which HIV can lead to immune dysfunction in AIDS patients...
- Skewed expression and up-regulation of the IL-12 and IL-18 receptors in resting and activated CD4 T cells from HIV-1-infected patientsGuillermo Robert de Arquer
Fundacio irsiCaixa, HIVACAT, Hospital Universitari Germans Trias i Pujol, Ctra Canyet sn, 08916 Badalona, Spain
J Leukoc Biol 82:72-8. 2007..Furthermore, the percentage of IL-12Rbeta1-positive cells correlated inversely with the CD4 nadir of patients, suggesting that deregulation of the IL-12 and IL-18 pathways may play a role in the immunopathogenesis of HIV-1 infection...
- The relationship between ApoE, TNFA, IL1a, IL1b and IL12b genes and HIV-1-associated dementiaL A Pemberton
Centre for Immunology, St Vincent s Hospital, Darlinghurst, NSW, Australia
HIV Med 9:677-80. 2008..Host genetic factors implicated in AIDS dementia complex (ADC) were studied...
- HIV-1 Nef inhibits lipopolysaccharide-induced IL-12p40 expression by inhibiting JNK-activated NFkappaB in human monocytic cellsWei Ma
Department of Pathology, Research Institute, Children s Hospital of Eastern Ontario, Ottawa, Ontario K1H 8L1, Canada
J Biol Chem 284:7578-87. 2009..Overall, our results suggest for the first time that intracellular nef inhibited LPS-activated JNK, which may cause inhibition of IL-12p40 expression in human monocytic cells by selectively inhibiting NFkappaB activity...
- Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5D Sieburth
Genetic Institute, Cambridge, Massachusetts 02140
Genomics 14:59-62. 1992..The subunits map to different chromosomes: p40 (IL12B) to 5q31-q33 and p35 (IL12A) to 3p12-3q13.2.
- IL-12p40 is associated with type 1 diabetes in Caucasian-American familiesAbdoreza Davoodi-Semiromi
Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, Florida, USA
Diabetes 51:2334-6. 2002..These results provide genetic and functional evidence for IL-12p40 as a type 1 diabetes susceptibility gene...
- The IL12B gene is associated with asthmaAdrienne G Randolph
Channing Laboratory, Brigham and Women s Hospital, Department of Anesthesia, Children s Hospital, and Harvard Medical School, Boston, MA, USA
Am J Hum Genet 75:709-15. 2004The IL12B gene on chromosome 5q31-33 encodes the p40 subunit of interleukin 12, an immunomodulatory cytokine...
- Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasisFrancesca Capon
Department of Medical and Molecular Genetics, Division of Genetics and Molecular Medicine, King s College, London, UK
Hum Genet 122:201-6. 2007..00014. Next, we examined genetic variation at the IL12RB1, IL23A and IL12B genes, respectively, encoding the second subunit of the IL23R receptor and the two subunits of its ligand...
- Variants in the 5q31 cytokine gene cluster are associated with psoriasisM Chang
Celera, Alameda, CA 94502, USA
Genes Immun 9:176-81. 2008..74; P(comb)=7.05E-04). In combination with the other known genetic risk factors, HLA-C, IL12B and IL23R, the variants reported here generate an 11-fold psoriasis-risk differential...
- The inflammatory disease-associated variants in IL12B and IL23R are not associated with rheumatoid arthritisMonica Chang
Celera, Alameda, CA, USA
Arthritis Rheum 58:1877-81. 2008
- The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cellsX Ma
Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104, USA
J Exp Med 183:147-57. 1996..Two other elements, IRF-1 located at -730 to -719, and NF-IL6 at -520 to -512, were also studied by deletion analysis, which did not result in decreased response to IFN-gamma and LPS stimulation...
- Interleukin 12B (IL12B) genetic variation and pulmonary tuberculosis: a study of cohorts from The Gambia, Guinea-Bissau, United States and ArgentinaGerard A J Morris
MRC Laboratories, Fajara, The Gambia West Africa
PLoS ONE 6:e16656. 2011We examined whether polymorphisms in interleukin-12B (IL12B) associate with susceptibility to pulmonary tuberculosis (PTB) in two West African populations (from The Gambia and Guinea-Bissau) and in two independent populations from North ..
- Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cellsS F Wolf
Genetics Institute, Inc, Cambridge, MA 02140
J Immunol 146:3074-81. 1991..This factor, termed natural killer cell stimulatory factor (NKSF), possessed pleiotropic activities including the induction of IFN-gamma from PBL, enhancement of cytotoxicity by NK ..
- Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factorU Gubler
Department of Molecular Genetics, Roche Research Center, Hoffmann La Roche, Inc, Nutley, NJ 07110
Proc Natl Acad Sci U S A 88:4143-7. 1991Cytotoxic lymphocyte maturation factor (CLMF) is a disulfide-bonded heterodimeric lymphokine that (i) acts as a growth factor for activated T cells independent of interleukin 2 and (ii) synergizes with suboptimal concentrations of ..
- Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activityP Ling
Department of Inflammation Autoimmune Diseases, Hoffmann La Roche, Inc, Nutley, NJ 07110
J Immunol 154:116-27. 1995..When p40 is associated with a p35 subunit, the heterodimer acts as an agonist mediating biologic activity. However, when p40 associates with another p40, the homodimer behaves as an antagonist in vitro...
- Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor alpha productionA D'ANDREA
Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104
J Exp Med 181:537-46. 1995..These results suggest an unexpected complexity in the regulatory role of IL-4 and IL-13 in immune responses...
- Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonistS Gillessen
Department of Inflammation Autoimmune Diseases, Hoffmann La Roche Inc, Nutley, NJ 07110
Eur J Immunol 25:200-6. 1995..Further studies are required to determine whether or not (p40)2 is produced by normal lymphoid cells and is a physiologic regulator of IL-12 activity...
- Impairment of mycobacterial immunity in human interleukin-12 receptor deficiencyF Altare
INSERM U429, Hopital Necker Enfants Malades, Paris 75015, France
Science 280:1432-5. 1998..Thus, IL-12-dependent IFN-gamma secretion in humans seems essential in the control of mycobacterial infections, despite the formation of mature granulomas due to IL-12-independent IFN-gamma secretion...
- Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12B Oppmann
DNAX Research Institute, Palo Alto, CA 94304, USA
Immunity 13:715-25. 2000..Similar to IL-12, human IL-23 stimulates IFN-gamma production and proliferation in PHA blast T cells, as well as in CD45RO (memory) T cells...
- Genetic polymorphism of IL-12 p40 gene in immune-mediated diseaseM A Hall
Department of Rheumatology, Division of Medicine, 5th Floor Thomas Guy House, Guy s, King s and St Thomas Hospitals School of Medicine, King s College, Guy s Hospital Campus, London SE1 9RT, UK
Genes Immun 1:219-24. 2000..02 95% CI 0.95-4.3). This new genetic marker could be useful in anthropological studies and should be investigated in other autoimmune, allergic, inflammatory and infectious diseases...
- Complete primary structure, chromosomal localisation, and definition of polymorphisms of the gene encoding the human interleukin-12 p40 subunitD Huang
Complex Genetic Diseases Laboratory, and Cooperative Research Centre for Discovery of Genes for Common Human Diseases, Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria 3050, Australia
Genes Immun 1:515-20. 2000..This finding places constraints on any preferential involvement of alleles of IL-12p40 in contributing to autoimmune, inflammatory or infectious diseases...
- Native HIV-1 Tat protein targets monocyte-derived dendritic cells and enhances their maturation, function, and antigen-specific T cell responsesEmanuele Fanales-Belasio
Laboratory of Virology, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
J Immunol 168:197-206. 2002..Thus, Tat can act as both Ag and adjuvant, capable of driving T cell-mediated immune responses...
- Inherited interleukin-12 deficiency: IL12B genotype and clinical phenotype of 13 patients from six kindredsCapucine Picard
Laboratoire de Genetique Humaine des Maladies Infectieuses, Université René Descartes INSERM U550, Faculte de Medecine Necker, Paris, France
Am J Hum Genet 70:336-48. 2002..It consists of two subunits, p35 and p40, which are encoded by IL12A and IL12B, respectively...
- A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23RChristi Parham
Department of Immunology, DNAX Research, Palo Alto, CA 94304, USA
J Immunol 168:5699-708. 2002..The ability of cells to respond to IL-23 or IL-12 correlates with expression of IL-23R or IL-12Rbeta2, respectively. The human IL-23R gene is on human chromosome 1 within 150 kb of IL-12Rbeta2...
- Association of IL12B promoter polymorphism with severity of atopic and non-atopic asthma in childrenGrant Morahan
The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria 3050, Australia
Lancet 360:455-9. 2002..There is no genetic explanation for how hyper-responsiveness to these disparate environmental stimuli develops among individuals with asthma. Our aim was to assess relation between an IL12B promoter polymorphism and asthma.
- Interleukin-12 p40 gene (IL12B) 3'-untranslated region polymorphism is associated with susceptibility to atopic dermatitis and psoriasis vulgarisYuichiro Tsunemi
Department of Dermatology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
J Dermatol Sci 30:161-6. 2002..The IL-12 p40 subunit gene (IL12B) is located at chromosome 5q31-33 and linkage findings of AD on 5q31 were reported...
- Regulation of virus-induced IL-12 and IL-23 expression in human macrophagesJaana Pirhonen
Department of Microbiology, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
J Immunol 169:5673-8. 2002..IFN-gamma, in contrast, up-regulates the p19 and p40 mRNA expression in Sendai virus infection. Thus, IL-4 and IFN-gamma serve as opposing factors in the regulation of IFN-gamma-inducing cytokines, including IL-23, in macrophages...
- A TaqI polymorphism in the 3'UTR of the IL-12 p40 gene correlates with increased IL-12 secretionD Seegers
The Mucosal Immunity Section, National Institutes of Health, Bethesda, MD, USA
Genes Immun 3:419-23. 2002..While this polymorphism does not appear to be correlated with susceptibility to CD in the limited population of patients tested here, it could influence the occurrence of the disease in certain subsets of patients...
- Association between IFNA genotype and the risk of sarcoidosisMitsuteru Akahoshi
Laboratory for Genetics of Allergic Diseases, SNP Research Center, Institute of Physical and Chemical Research, RIKEN Yokohama Institute, Yokohama, Japan
Hum Genet 114:503-9. 2004..polymorphisms within 10 candidate genes involved in type 1 immune process ( IFNA17, IFNB, IFNG, IFNGR1, IFNGR2, IL12B, IL12RB1, IL12RB2, ETA-1, and NRAMP1) in an association-based study of 102 Japanese patients with sarcoidosis, 114 ..
- HLA and cytokine gene polymorphisms are independently associated with responses to hepatitis B vaccinationChengbin Wang
Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, USA
Hepatology 39:978-88. 2004..with single nucleotide polymorphisms (SNPs) at the IL2 and IL4 loci along with insertion/deletion variants at the IL12B locus (P =.003-.01)...
- Associations between IL12B polymorphisms and tuberculosis in the Hong Kong Chinese populationHoi W Tso
Department of Pediatrics and Adolescent Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region, China
J Infect Dis 190:913-9. 2004..Interleukin (IL)-12 plays a vital role in regulating cell-mediated immunity against tuberculosis (TB)...
- Definition of polymorphisms and haplotypes in the interleukin-12B gene: association with IL-12 production but not with Crohn's diseaseA Zwiers
Laboratory of Immunogenetics, Vrije Universiteit Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
Genes Immun 5:675-7. 2004..Recently, functional polymorphisms in IL-12p40 (IL12B) were found to be associated with susceptibility to several autoimmune diseases...
- Alleles of the IL12B 3'UTR associate with late onset of type 1 diabetesLydia Windsor
School of Surgery and Pathology, University of Western Australia Nedlands, Australia
Hum Immunol 65:1432-6. 2004Carriage of a polymorphism in the 3'untranslated region of the IL12B gene encoding IL-12p40 was investigated in subjects with type 1 diabetes mellitus stratified by age at diagnosis (n = 648) and compared with a population-based control ..
- Taq-I polymorphism in 3'UTR of the IL-12B and association with IL-12p40 production from human PBMCS Stanilova
Department of Molecular Biology, Immunology and Genetics, Faculty of Medicine, Trakia University, Stara Zagora, Bulgaria
Genes Immun 6:364-6. 2005....
- Association between the 1188 A/C polymorphism in the human IL12B gene and Th1-mediated infectious diseasesM B Freidin
Int J Immunogenet 33:231-2. 2006
- A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genesMichele Cargill
Celera, Alameda, CA 94502, USA
Am J Hum Genet 80:273-90. 2007..with 25,215 genecentric single-nucleotide polymorphisms (SNPs) and found a highly significant association with an IL12B 3'-untranslated-region SNP (rs3212227), confirming the results of a small Japanese study...
- Association of polymorphisms in IL-12/IFN-gamma pathway genes with susceptibility to pulmonary tuberculosis in IndonesiaEdhyana Sahiratmadja
Eijkman Institute for Molecular Biology, Jakarta, Indonesia
Tuberculosis (Edinb) 87:303-11. 2007..We analyzed the distribution of polymorphisms in four essential genes from the IL-12/IFN-gamma axis, IL12B, IL12RB1, IFNG and IFNGR1, in 382 pulmonary tuberculosis patients and 437 healthy controls from an endemic region ..
- Association of variants in the IL12B gene with leprosy and tuberculosisG Morahan
Diabetes Research Centre, Western Australia Institute for Medical Research, Perth, WA, Australia
Tissue Antigens 69:234-6. 2007..One of the key cytokine regulators of the immune response is interleukin (IL-) 12. The IL12B gene encodes the p40 chain of both IL-12 and IL-23 and it has two major variant sites at which different alleles ..
- Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibilityMiles Parkes
Inflammatory Bowel Disease Research Group, Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 2QQ, UK
Nat Genet 39:830-2. 2007..We obtained replication for the autophagy-inducing IRGM gene on chromosome 5q33.1 (replication P = 6.6 x 10(-4), combined P = 2.1 x 10(-10)) and for nine other loci, including NKX2-3, PTPN2 and gene deserts on chromosomes 1q and 5p13...
- Polymorphism in the 3' UTR of the IL12B gene is associated with Chagas' disease cardiomyopathyGerman Zafra
Grupo de Inmunología y Epidemiología Molecular, GIEM, Facultad de Salud, Universidad Industrial de Santander, Carrera 32 29 31, Bucaramanga AA 678, Colombia
Microbes Infect 9:1049-52. 2007..of this study was to investigate the possible influence of a 3' untranslated region (3' UTR) polymorphism of the IL12B gene in susceptibility to Trypanosoma cruzi infection or in the development to cardiomyopathy in Chagas' disease (..
- Interleukin-12B & interleukin-10 gene polymorphisms in pulmonary tuberculosisS Prabhu Anand
Tuberculosis Research Centre ICMR, Chennai, India
Indian J Med Res 126:135-8. 2007..The aim of this study was to know whether Interleukin-12B 3' UTR (Taq1) (A/C) and Interleukin-10 (-1082 G/A) gene polymorphisms were associated with susceptibility to pulmonary tuberculosis...
- Increased circulating interleukin (IL)-23 in children with malarial anemia: in vivo and in vitro relationship with co-regulatory cytokines IL-12 and IL-10John M Ong'echa
University of Pittsburgh KEMRI Laboratories of Parasitic and Viral Diseases, Centre for Vector Biology and Control Research, Kenya Medical Research Institute, Kisumu, Kenya
Clin Immunol 126:211-21. 2008..Taken together, results here show that IL-23 is elevated in children with malarial anemia, and that IL-10 and IL-12 appear to have important regulatory effects on IL-23 production during childhood malaria...
- Polymorphisms in the IL-12beta and IL-23R genes are associated with psoriasis of early onset in a UK cohortRhodri L L Smith
J Invest Dermatol 128:1325-7. 2008
- The autoimmune disease-associated IL12B and IL23R polymorphisms in multiple sclerosisAnn B Begovich
Celera, Alameda, CA, USA
Hum Immunol 68:934-7. 2007..in psoriasis, inflammatory bowel disease, and ankylosing spondylitis identified significant associations with IL12B and IL23R polymorphisms...
- Polymorphisms of the IL12B and IL23R genes are associated with psoriasisRajan P Nair
Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0932, USA
J Invest Dermatol 128:1653-61. 2008..A recent study reported that psoriasis was associated with the IL12B haplotype rs3212227 (3'-untranslated region)-rs6887695 (60 kb, 5') and the IL23R haplotype rs7530511 (L310P)-..
- A role for interleukin-12/23 in the maturation of human natural killer and CD56+ T cells in vivoSophie Guia
Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Marseille, France
Blood 111:5008-16. 2008....
- A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease lociYing Liu
Division of Human Genetics, Department of Genetics, Washington University School of Medicine, St Louis, Missouri, United States of America
PLoS Genet 4:e1000041. 2008..We replicated the previously reported association with interleukin 23 receptor and interleukin 12B (IL12B) polymorphisms in PS and PSA cohorts (IL23R: rs11209026, U.S. PS, P = 1.4x10(-4); U.K. PSA: P = 8...
- IL23R and IL12B polymorphisms in Spanish IBD patients: no evidence of interactionAna Marquez
Clinical Immunology Department, Hospital Clinico San Carlos, Madrid, Spain
Inflamm Bowel Dis 14:1192-6. 2008Recent genomic surveys have identified IL23R and IL12B as susceptibility loci for inflammatory bowel disease (IBD)...
- A functional promoter variant in IL12B predisposes to cerebral malariaSandrine Marquet
INSERM, UMR906, Genetics and Immunology of Parasitic Diseases, Marseille F 13005, France
Hum Mol Genet 17:2190-5. 2008..We investigated 21 markers in IL12-related genes, including IL12A and IL12B encoding the two IL-12 (IL12p70) subunits, IL12p35 and IL12p40...
- IL12B polymorphisms are linked but not associated with Plasmodium falciparum parasitemia: a familial study in Burkina FasoM Barbier
Aix Marseille Universite, IFR 48, Faculte de Pharmacie, Laboratoire de Pharmacogénétique des Maladies Parasitaires, Marseille, France
Genes Immun 9:405-11. 2008..This chromosomal region contains numerous immunoregulatory genes. Among these, IL12B that encodes the p40 subunit of interleukin-12 (IL-12) appeared to be a promising functional candidate gene, and ..
- The 3'UTR 1188 A/C polymorphism in the interleukin-12p40 gene (IL-12B) is associated with lepromatous leprosy in the west of MexicoAnabell Alvarado-Navarro
Centro de Investigacion en Inmunologia y Dermatologia, Departamento de Fisiologia, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico
Immunol Lett 118:148-51. 2008..These data suggest that IL-12 p40 3'UTR 1188 A/C polymorphism is associated with greater susceptibility to lepromatous leprosy in patients from western Mexico, independently of IL-12 p40 and p70 expression levels...
- Genetic variants of the IL-23R pathway: association with psoriatic arthritis and psoriasis vulgaris, but no specific risk factor for arthritisUlrike Huffmeier
Institute of Human Genetics, University Hospital Erlangen, University Erlangen Nuremberg, Erlangen, Germany
J Invest Dermatol 129:355-8. 2009..Four variants of the IL12B and IL23R genes were analyzed in 1,114 PV patients, 748 patients with psoriatic arthritis (PA) and 937 healthy ..
- Investigation of association of the IL12B and IL23R genes with psoriatic arthritisCharlotte Filer
University of Manchester, Manchester, UK
Arthritis Rheum 58:3705-9. 2008..The aim of this study was to determine whether these variants are also associated with susceptibility to psoriatic arthritis (PsA)...
- IL-23 modulates CD56+/CD3- NK cell and CD56+/CD3+ NK-like T cell function differentially from IL-12Diederik van de Wetering
Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
Int Immunol 21:145-53. 2009....
- Interactions of IL-12A and IL-12B polymorphisms on the risk of cervical cancer in Chinese womenXiaojun Chen
Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China
Clin Cancer Res 15:400-5. 2009..We hypothesized that potentially functional polymorphisms in IL12A and IL12B may individually and jointly contribute to cervical cancer risk.
- Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathwaysRajan P Nair
Department of Dermatology, University of Michigan, Ann Arbor, Michigan 48109, USA
Nat Genet 41:199-204. 2009..Loci with confirmed association include HLA-C, three genes involved in IL-23 signaling (IL23A, IL23R, IL12B), two genes that act downstream of TNF-alpha and regulate NF-kappaB signaling (TNIP1, TNFAIP3) and two genes ..
- Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn DiseaseKai Wang
Center for Applied Genomics, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Am J Hum Genet 84:399-405. 2009..Interestingly, the pathway contains multiple genes (IL12B and JAK2) or homologs of genes (STAT3 and CCR6) that were recently identified as genuine susceptibility genes only ..
- Serum levels of interleukin-10 and interleukin-12 predict early, spontaneous hepatitis B virus e antigen seroconversionJia Feng Wu
Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
Gastroenterology 138:165-72.e1-3. 2010..This prospective cohort study aimed to determine the effect of cytokines on spontaneous hepatitis B e antigen (HBeAg) seroconversion in patients with chronic hepatitis B virus (HBV) infection...
- Genetic analysis in a Dutch study sample identifies more ulcerative colitis susceptibility loci and shows their additive role in disease riskEleonora A M Festen
Department of Gastroenterology and Hepatology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
Am J Gastroenterol 105:395-402. 2010..Genetic susceptibility is known to make a major contribution to the pathogenesis of ulcerative colitis (UC). Recently, three studies, including a genome-wide association study (GWAS), reported novel UC risk loci...
- Allelic polymorphism of cytokine genes during pulmonary tuberculosisI O Naslednikova
Department of Pathophysiology, Department of Phthisiology and Pulmonology, Siberian State Medical University, Federal Agency of Health Care and Social Development, Tomsk, Russia
Bull Exp Biol Med 148:175-80. 2009..T allele and TT genotype of C-590T polymorphism in the IL4 gene, and CC genotype of A-1188C polymorphism in the IL12B gene are immunogenetic factors that have protective activity against susceptibility to pulmonary tuberculosis...
- Association of single nucleotide polymorphisms in the IL-12 (IL-12A and B) and IL-12 receptor (IL-12Rbeta1 and beta2) genes and gene-gene interactions with atopic dermatitis in KoreansJung Hyun Namkung
Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon Dong, Gangnam Gu, Seoul 135 710, South Korea
J Dermatol Sci 57:199-206. 2010..The acute skin lesions of atopic dermatitis (AD) are associated with Th2 cells; however, the chronic skin lesions of AD are associated with Th1 cells via the action of IL-12...
- Polymorphisms in genes of interleukin 12 and its receptors and their association with protection against severe malarial anaemia in children in western KenyaLyna Zhang
Malaria Branch, Division of Parasitic Diseases, National Center for Zoonotic, Vector Borne and Enteric Diseases, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
Malar J 9:87. 2010..Based on the biological relevance of IL12 in malaria anaemia, the relationship between genetic polymorphisms of IL12 and its receptors and SMA was examined...
- Haplotypes of IL12B promoter polymorphisms condition susceptibility to severe malaria and functional changes in cytokine levels in Thai adultsChintana Phawong
Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok, 10400, Thailand
Immunogenetics 62:345-56. 2010Polymorphic variability in immune response genes, such as IL12B, encoding the IL-12p40 subunit is associated with susceptibility to severe malaria in African populations...
- IL12 polymorphisms, HBV infection and risk of hepatocellular carcinoma in a high-risk Chinese populationLi Liu
Department of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, Nanjing, China
Int J Cancer 128:1692-6. 2011To investigate the association between the potentially functional polymorphisms in IL12A and IL12B, HBV infection and risk of hepatocellular carcinoma in a Chinese population, we genotyped three polymorphisms, rs568408 (3'UTR G>A), ..
- Analysis of eight genes modulating interferon gamma and human genetic susceptibility to tuberculosis: a case-control association studyMarlo Möller
Molecular Biology and Human Genetics, MRC Centre for Molecular and Cellular Biology, Faculty of Health Sciences, PO Box 19063, Stellenbosch University, Tygerberg 7505, South Africa
BMC Infect Dis 10:154. 2010..tuberculosis. Based on the hypothesis that genes which regulate interferon gamma may influence tuberculosis susceptibility, we investigated polymorphisms in eight candidate genes...
- A polymorphism in the coding region of Il12b promotes IL-12p70 and IL-23 heterodimer formationAntonie Zwiers
Department of Gastroenterology and Hepatology, Vrije Universiteit Medical Center, 1007 MB Amsterdam, The Netherlands
J Immunol 186:3572-80. 2011..In this study, we investigated how polymorphisms in the coding region of murine Il12b influence IL-12 and IL-23 heterodimer formation...
- Polymorphic variability in the 3' untranslated region (UTR) of IL12B is associated with susceptibility to severe anaemia in Kenyan children with acute Plasmodium falciparum malariaJohn M Ong'echa
Centre for Global Health Research, University of New Mexico Laboratories of Parasitic and Viral Diseases, Kenya Medical Research Institute, Kisumu, Kenya
BMC Genet 12:69. 2011..Since the role of IL12B variants in conditioning susceptibility to SMA remains largely unexplored, the association between a single ..
- Association of IL-12B genetic polymorphism with the susceptibility and disease severity of ankylosing spondylitisRuey Hong Wong
Institute of Medicine, Chung Shan Medical University, No 110 Chien Kuo N Road, Section 1, Taichung 40201, Taiwan
J Rheumatol 39:135-40. 2012..IL-12B encodes a p40 subunit common to IL-12 and IL-23. We evaluated the effects of IL-12B and IL-23R genotype on the occurrence and clinical features of AS...
- Single nucleotide polymorphism in the interleukin 12B gene is associated with risk for breast cancer developmentM H Kaarvatn
Molecular Genetics Laboratory, Department of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway
Scand J Immunol 76:329-35. 2012We analysed the association of a single nucleotide polymorphism (SNP) in the gene encoding the IL-12 subunit p40 (IL12B, rs3212227, A>C) with breast cancer...
- Associations between polymorphisms in IL-12A, IL-12B, IL-12Rβ1, IL-27 gene and serum levels of IL-12p40, IL-27p28 with esophageal cancerYi Peng Tao
Department of Thoracic Surgery, First Affiliated Hospital of Xinxiang Medical University, Weihui City, 453100 Henan Province, People s Republic of China
J Cancer Res Clin Oncol 138:1891-900. 2012..The aim of this study was to investigate whether IL-12A, IL-12B, IL-12Rβ1, and IL-27 gene polymorphisms and serum levels of IL-12, IL-27 are associated with esophageal cancer...
- Susceptibility-associated genetic variation at IL12B enhances Th1 polarization in psoriasisAndrew Johnston
Department of Dermatology, University of Michigan, Ann Arbor, MI 48109, USA
Hum Mol Genet 22:1807-15. 2013The IL12B gene encodes the common p40 subunit of IL-12 and IL-23, cytokines with key roles in Th1 and Th17 biology, respectively, and genetic variation in this region significantly influences risk of psoriasis...
- IL12B and IL23R gene SNPs in Japanese psoriasisAkira Oka
The Institute of Medical Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259 1193, Japan
Immunogenetics 65:823-8. 2013..The IL12B gene, which encodes the shared IL-12p40 subunit in two cytokines, IL-12 and IL-23, and the IL23R gene, which ..
- Association of interleukin-12 polymorphisms and serum IL-12p40 levels with osteosarcoma riskJunli Wang
1 Center of Clinical Laboratory, Affiliated Hospital of Youjiang Medical College for Nationalities, Baise, China
DNA Cell Biol 32:605-10. 2013..Our data suggest that the serum IL-12p40 levels associate with the risk of osteosarcoma and are regulated by IL-12B rs3212227 polymorphism. The IL-12A rs568408 and IL-12B rs3212227 may confer the susceptibility to osteosarcoma risk. ..
- Local production of the p40 subunit of interleukin 12 suppresses T-helper 1-mediated immune responses and prevents allogeneic myoblast rejectionK Kato
Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
Proc Natl Acad Sci U S A 93:9085-9. 1996..Therefore, IL-12p40 gene transduction would be useful for preventing the rejection of allografts and genetically modified own cells that are transduced with potentially antigenic molecules in gene therapy...
- Involvement of dihydropyridine-sensitive calcium channels in human dendritic cell function. Competition by HIV-1 TatA Poggi
Laboratory of Immunopathology, National Institute for Cancer Research and Advanced Biotechnology Center, Genoa 16132, Italy
J Biol Chem 273:7205-9. 1998..Taken together, these findings indicate that exogenous Tat exerts its inhibitory effects on dendritic cells by blocking dihydropyridine-sensitive L-type calcium channels...
- Role of Toll-like receptor 9 in Legionella pneumophila-induced interleukin-12 p40 production in bone marrow-derived dendritic cells and macrophages from permissive and nonpermissive miceCathy A Newton
Department of Molecular Medicine, MDC Box 10, University of South Florida College of Medicine, 12901 Bruce B Downs Boulevard, Tampa, FL 33612, USA
Infect Immun 75:146-51. 2007....
- A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytesO Devergne
Department of Microbiology and Molecular Genetics, Harvard University, Boston, Massachusetts, USA
J Virol 70:1143-53. 1996..EBI3 synthesis by trophoblasts and by EBV-transformed cells and similarities to interleukin-12 p40 are compatible with a role for EBI3 in regulating cell-mediated immune responses...
- JAMES TILFORD ELDER; Fiscal Year: 2016..association signal distinct from HLA-Cw6 as well as genome- wide significance for multiple non-MHC loci including IL12B, TNFAIP3, TNIP1, and TYK2, and TRAF3IP2 ...
- Jean Laurent Casanova; Fiscal Year: 2016..MSMD over the last fifteen years has identified six morbid genes, including five autosomal (IFNGR1, IFNGR2, STAT1, IL12B, IL12RB1) and one X- linked (NEMO) gene...
- Jean Laurent Casanova; Fiscal Year: 2014..of MSMD over the last 15 years has identified six morbid genes, including five autosomal (IFNGR1, IFNGR2, STAT1, IL12B, IL12RB1) and one X-linked (NEMO) gene...
- Immunogenetics of Cervical Cancer A Family-Based DesignStephen Schwartz; Fiscal Year: 2005..We hypothesize that variation in the genes encoding the cytokines IL10 and IL12 (IL10, IL12A and IL12B) is associated with invasive cervical cancer risk in women persistently infected with HPV...
- JAMES TILFORD ELDER; Fiscal Year: 2016..Of these loci, three confirm previous reports of association (at HLA-C, IL12B, IL23R) and four identify novel signals located near plausible candidate genes (IL23A, IL13, TNFAIP3, and TNIP1)...
- Identification of Psoriatic Arthritis GenesJAMES TILFORD ELDER; Fiscal Year: 2013..scanning the rest of the genome for PsA loci, we assessed the top 7 confirmed associations from CASP (HLA-C, IL12B, TNIP1, IL13, TNFAIP3, IL23A, and IL23R) in 1,755 PsA cases vs...
- Lionel B Ivashkiv; Fiscal Year: 2016..genes important for host defense against intracellular pathogens and Th1 responses: Il12a (encoding IL-12 p35), Il12b (p40) and Nos2 (iNOS). Expression of these genes is regulated by IRF1, IRF8 and the NF-?B family member c-Rel...
- Genotyping the NPF Biobank for Psoriasis Susceptibility GenesJAMES TILFORD ELDER; Fiscal Year: 2010..The loci with confirmed association encode HLA-C, three genes involved in IL-23 signaling (IL23A, IL23R and IL12B), two genes that act downstream of TNF-[unreadable] and regulate NF-[unreadable]B signaling (TNIP1 and TNFAIP3), ..
- Pioneer factor interactions in embryonic stem cellsStephen T Smale; Fiscal Year: 2010..hypothesis, we recently demonstrated that well-characterized enhancers for three tissue-specific genes, Ptcra, Il12b, and Alb1, are selectively marked by unmethylated CpG dinucleotides in pluripotent ES cells...
- IMMUNOGENETIC MECHANISMS OF VACCINE RESPONSEGregory A Poland; Fiscal Year: 2010..The knowledge gained from these studies will enable us to design new strategies and new vaccines to protect human health against viral diseases. ..
- Organ Culture of Basal Cell CarcinomaJames Elder; Fiscal Year: 2002....
- Amphiregulin in Psoriatic Epidermal HyperplasiaJAMES TILFORD ELDER; Fiscal Year: 2010..If successful, this research will have important public health consequences not only in psoriasis but also in a wide variety of dermatoses characterized by epidermal hyperplasia. ..
- Genome-wide association of common alleles with long-term diabetic complicationsAndrew Paterson; Fiscal Year: 2008..unreadable] [unreadable]..
- The Natural History of Pediatric Crohn's DiseaseMarla Dubinsky; Fiscal Year: 2008..abstract_text> ..
- Mapping Chromosome 3q Inflammatory Bowel Disease GenesJUDY CHO; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Parental Expression of Immune Responses In Pediatric Crohn's DiseaseMarla Dubinsky; Fiscal Year: 2008..unreadable] [unreadable]..
- Host Genetic Factors in the HIV Virus Life-Cycle and HIV Disease ProgressionJairam Lingappa; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Molecular Epidemiology of non-Hodgkin Lymphoma SurvivalJames R Cerhan; Fiscal Year: 2010..Host genetics may also lead to a better understanding of NHL pathophysiology that could lead to new approaches to improve the survival of NHL patients. ..
- MOLECULAR MODELING OF DIAGNOSIS AND PROGNOSIS IN HNSCCMaria Worsham; Fiscal Year: 2009..abstract_text> ..
- Adenosine in trauma and sepsisGyorgy Hasko; Fiscal Year: 2007..abstract_text> ..
- IL-12-Faciliated Hematopoietic Recovery Following Myeloablative TherapyDan Douer; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Immunogenetics of Non-Hodgkin Lymphoma SurvivalJames Cerhan; Fiscal Year: 2006..abstract_text> ..
- Spondyloarthritis 2006; The Unmet NeedsJohn Reveille; Fiscal Year: 2006..unreadable] [unreadable] [unreadable] [unreadable]..
- Arsenic Trioxide and Vitamin C in AMLDan Douer; Fiscal Year: 2005..In summary, this combination may have higher benefit/risk ratio in non-APL AML patients resulting in an overall better outcome with less toxicity than conventional chemotherapy. ..
- IMMUNOTOXICOLOGY OF A HEAVY METALKenneth Pollard; Fiscal Year: 2004..Analysis of the interaction between fibrillarin, mercury and cells of the lymphoid system may lead to insights into how an imunotoxin renders self-antigen immunogenic. ..
- Large Scale Images of Gene Transcription in MS and EAELawrence Steinman; Fiscal Year: 2004..The discovery of the role of osteopontin, first identified in large scale profiles, exemplifies how this approach may help us to understand MS and to develop new therapies. ..
- IDENTIFYING MAJOR SUSCEPTIBILITY GENES OF IBDJUDY CHO; Fiscal Year: 2003..Once risk alleles are identified in multiplex families, characterization of the nature and broad significance of specific risk alleles for IBD in a variety of populations will be performed. ..
- FAMILY STUDIES OF THE GENETICS OF ANKYLOSING SPONDYLITISJohn Reveille; Fiscal Year: 2003..abstract_text> ..
- IN VIVO TREATMENT OF EAE WITH ANTI I-A ANTIBODIESLawrence Steinman; Fiscal Year: 2001..Aim 5 is to assess the possibility of using DNA vaccination against TCR Vb for treatment of EAE. It is hoped that these studies will provide the basis for future clinical trials in MS patients. ..
- BECTON DICKINSON FACS CALIBUR 4 COLOR WITH SORT UNITKenneth Pollard; Fiscal Year: 2001..Flow cytometry will be used to select and sort cell populations prior to and after transplantation studies. ..
- MERCURY INDUCED AUTOIMMUNITYKenneth Pollard; Fiscal Year: 2007..Identification of the role that IFN-gamma plays in the development of induced murine systemic autoimmunity should prove applicable to murine models of idiopathic systemic autoimmunity and to human lupus. ..
- XENOBIOTIC ACCELERATION OF AUTOIMMUNITYKenneth Pollard; Fiscal Year: 2003..abstract_text> ..
- PEPTIDE MEDIATED IMMUNOTHERAPY FOR AUTOIMMUNE DISEASELawrence Steinman; Fiscal Year: 2003..This work with APL may be applicable not only to MS, but to other autoimmune diseases including juvenile diabetes, rheumatoid arthritis, and inflammatory bowel disease. ..
- CANNABINOID RECEPTORS ON IMMUNE CELLSThomas Klein; Fiscal Year: 2003..The experiments proposed will increase our understanding of the imnunobiology of the cannabinoid system and shed light on the health consequences of medicinal marijuana use in HIV disease. ..
- BENIGN BREAST DISEASE--MOLECULAR DIFFERENTIATION OF RISKMaria Worsham; Fiscal Year: 2001....