Gene Symbol: IL-8
Description: chemokine (C-X-C motif) ligand 8
Alias: GCP-1, GCP1, IL8, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1, T-cell chemotactic factor, alveolar macrophage chemotactic factor I, beta endothelial cell-derived neutrophil activating peptide, beta-thromboglobulin-like protein, emoctakin, granulocyte chemotactic protein 1, interleukin 8, lung giant cell carcinoma-derived chemotactic protein, lymphocyte derived neutrophil activating peptide, monocyte-derived neutrophil chemotactic factor, monocyte-derived neutrophil-activating peptide, neutrophil-activating peptide 1, small inducible cytokine subfamily B, member 8, tumor necrosis factor-induced gene 1
Species: human

Top Publications

  1. pmc The IL-8-regulated chemokine receptor CXCR7 stimulates EGFR signaling to promote prostate cancer growth
    Rajendra Kumar Singh
    Department of Urology and Radiation Oncology, Sylvester Cancer Center, University of Miami School of Medicine, Miami, FL, USA
    Cancer Res 71:3268-77. 2011
  2. doi The effects of genetic polymorphisms of IL-6, IL-8, and IL-10 on Helicobacter pylori-induced gastroduodenal diseases in Korea
    Jung Mook Kang
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
    J Clin Gastroenterol 43:420-8. 2009
  3. pmc Interleukin-8 mediates resistance to antiangiogenic agent sunitinib in renal cell carcinoma
    Dan Huang
    Laboratory of Cancer Genetics, Laboratory of Computational Biology, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    Cancer Res 70:1063-71. 2010
  4. pmc Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network
    Arturo V Orjalo
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Proc Natl Acad Sci U S A 106:17031-6. 2009
  5. ncbi Interleukin-8, a chemotactic and inflammatory cytokine
    M Baggiolini
    Theodor Kocher Institute, University of Bern, Switzerland
    FEBS Lett 307:97-101. 1992
  6. doi Circulating interleukin (IL)-8, IL-2R, IL-12, and IL-15 levels are independently prognostic in primary myelofibrosis: a comprehensive cytokine profiling study
    Ayalew Tefferi
    Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    J Clin Oncol 29:1356-63. 2011
  7. doi Differential expression of the chemokines GRO-2, GRO-3, and interleukin-8 in colon cancer and their impact on metastatic disease and survival
    Dietrich Doll
    Department of Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    Int J Colorectal Dis 25:573-81. 2010
  8. doi Leptin induces IL-8 expression via leptin receptor, IRS-1, PI3K, Akt cascade and promotion of NF-kappaB/p300 binding in human synovial fibroblasts
    Kwok Man Tong
    Department of Orthopaedics, Taichung Veterans General Hospital, Taichung, Taiwan
    Cell Signal 20:1478-88. 2008
  9. pmc α-1 Antitrypsin regulates human neutrophil chemotaxis induced by soluble immune complexes and IL-8
    David A Bergin
    1Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland
    J Clin Invest 120:4236-50. 2010
  10. ncbi The potential role of neutrophils in promoting the metastatic phenotype of tumors releasing interleukin-8
    Joseph E De Larco
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    Clin Cancer Res 10:4895-900. 2004

Detail Information

Publications297 found, 100 shown here

  1. pmc The IL-8-regulated chemokine receptor CXCR7 stimulates EGFR signaling to promote prostate cancer growth
    Rajendra Kumar Singh
    Department of Urology and Radiation Oncology, Sylvester Cancer Center, University of Miami School of Medicine, Miami, FL, USA
    Cancer Res 71:3268-77. 2011
    ..Together, these results reveal a novel mechanism of ligand-independent growth promotion by CXCR7 and its coregulation by the proinflammatory factor IL-8 in prostate cancer...
  2. doi The effects of genetic polymorphisms of IL-6, IL-8, and IL-10 on Helicobacter pylori-induced gastroduodenal diseases in Korea
    Jung Mook Kang
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
    J Clin Gastroenterol 43:420-8. 2009
    ..The present study was performed to evaluate whether or not the genetic polymorphisms of IL-6, IL-8, and IL-10 are associated with gastroduodenal disease in the Korean population...
  3. pmc Interleukin-8 mediates resistance to antiangiogenic agent sunitinib in renal cell carcinoma
    Dan Huang
    Laboratory of Cancer Genetics, Laboratory of Computational Biology, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    Cancer Res 70:1063-71. 2010
    ..Our results reveal IL-8 as an important contributor to sunitinib resistance in ccRCC and a candidate therapeutic target to reverse acquired or intrinsic resistance to sunitinib in this malignancy...
  4. pmc Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network
    Arturo V Orjalo
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Proc Natl Acad Sci U S A 106:17031-6. 2009
    ..Thus, cell surface IL-1alpha is an essential cell-autonomous regulator of the senescence-associated IL-6/IL-8 cytokine network...
  5. ncbi Interleukin-8, a chemotactic and inflammatory cytokine
    M Baggiolini
    Theodor Kocher Institute, University of Bern, Switzerland
    FEBS Lett 307:97-101. 1992
    ..IL-8 and the related cytokines are produced in several tissues upon infection, inflammation, ischemia, trauma etc., and are thought to be the main cause of local neutrophil accumulation...
  6. doi Circulating interleukin (IL)-8, IL-2R, IL-12, and IL-15 levels are independently prognostic in primary myelofibrosis: a comprehensive cytokine profiling study
    Ayalew Tefferi
    Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    J Clin Oncol 29:1356-63. 2011
    ..This study describes the spectrum of plasma cytokine abnormalities in primary myelofibrosis (PMF) and examines their phenotypic correlates and prognostic significance...
  7. doi Differential expression of the chemokines GRO-2, GRO-3, and interleukin-8 in colon cancer and their impact on metastatic disease and survival
    Dietrich Doll
    Department of Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    Int J Colorectal Dis 25:573-81. 2010
  8. doi Leptin induces IL-8 expression via leptin receptor, IRS-1, PI3K, Akt cascade and promotion of NF-kappaB/p300 binding in human synovial fibroblasts
    Kwok Man Tong
    Department of Orthopaedics, Taichung Veterans General Hospital, Taichung, Taiwan
    Cell Signal 20:1478-88. 2008
    ..These results suggest that leptin increased IL-8 production in synovial fibroblast via the OBRl/JAK2/STAT3 pathway, as well as the activation of IRS1/PI3K/Akt/NF-kappaB-dependent pathway and the subsequent recruitment of p300...
  9. pmc α-1 Antitrypsin regulates human neutrophil chemotaxis induced by soluble immune complexes and IL-8
    David A Bergin
    1Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland
    J Clin Invest 120:4236-50. 2010
    ..These results provide new insight into the mechanism underlying the effect of AAT augmentation therapy in the pulmonary disease associated with AAT deficiency...
  10. ncbi The potential role of neutrophils in promoting the metastatic phenotype of tumors releasing interleukin-8
    Joseph E De Larco
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    Clin Cancer Res 10:4895-900. 2004
    ..Possible targets are also presented for the development of therapies to attenuate the effects of the ectopic IL-8 release by tumor cells...
  11. ncbi Genetic polymorphisms of interleukin (IL)-1B, IL-1RN, IL-8, IL-10 and tumor necrosis factor {alpha} and risk of gastric cancer in a Chinese population
    Wanli Lu
    Department of Cancer Epidemiology, Peking University School of Oncology, Beijing Institute for Cancer Research, Beijing Cancer Hospital, Beijing 100036, People s Republic of China
    Carcinogenesis 26:631-6. 2005
    ..These findings suggest that genetic polymorphisms in IL-8, IL-10 and TNFalpha may play important roles in developing gastric cancer in the Chinese population...
  12. pmc Novel roles for hypoxia and prostaglandin E2 in the regulation of IL-8 during endometrial repair
    Jacqueline A Maybin
    University of Edinburgh Centre for Reproductive Biology, The Queen s Medical Research Institute, Edinburgh, Scotland
    Am J Pathol 178:1245-56. 2011
    ..Progesterone withdrawal, hypoxia, and PGE(2) regulate endometrial IL-8 by acting via HIF-1 and NF-κB. Hence, progesterone withdrawal may activate two distinct pathways to initiate endometrial repair...
  13. ncbi A molecular cascade showing nitric oxide-heme oxygenase-1-vascular endothelial growth factor-interleukin-8 sequence in human endothelial cells
    Hyun Ock Pae
    Department of Microbiology and Immunology, Wonkwang University School of Medicine, Shinyoung dong, Iksan Shi, Chonbug 570 749, Republic of Korea
    Endocrinology 146:2229-38. 2005
    ..Taken together, these results provide a molecular cascade showing NO-HO-1-VEGF-IL-8 sequence in human endothelial cells...
  14. ncbi Association between measures of insulin sensitivity and circulating levels of interleukin-8, interleukin-6 and tumor necrosis factor-alpha. Effect of weight loss in obese men
    Jens M Bruun
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital and Faculty of Health Sciences, Aarhus University, Tage Hansensgade 2, DK 8000 Aarhus C, Denmark
    Eur J Endocrinol 148:535-42. 2003
  15. doi SNAIL regulates interleukin-8 expression, stem cell-like activity, and tumorigenicity of human colorectal carcinoma cells
    Wei Lun Hwang
    Institution of Microbiology and Immunology, VGH YM Genome Research Center, National Yang Ming University, and Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan
    Gastroenterology 141:279-91, 291.e1-5. 2011
    ..Little is known about the mechanisms that regulate the stem cell-like features of cancer cells; we investigated genes associated with stem cell-like features of colorectal cancer (CRC) cells...
  16. pmc LPS-induced IL-8 activation in human intestinal epithelial cells is accompanied by specific histone H3 acetylation and methylation changes
    Tiziana Angrisano
    Dipartimento di Biologia e Patologia Cellulare e Molecolare L, Califano, Facoltà di Farmacia e Facoltà di Scienze Biotecnologiche, Universita degli Studi di Napoli Federico II, Via S, Pansini 5, Naples, 80131, Italy
    BMC Microbiol 10:172. 2010
  17. pmc Interleukin-8 induces the endothelial cell migration through the activation of phosphoinositide 3-kinase-Rac1/RhoA pathway
    Yi Lai
    Laboratory of Cardiovascular Diseases, West China Hospital, Sichuan University, Chengdu 610041, China
    Int J Biol Sci 7:782-91. 2011
  18. pmc Characterization of the interaction of interleukin-8 with hyaluronan, chondroitin sulfate, dermatan sulfate and their sulfated derivatives by spectroscopy and molecular modeling
    Annelie Pichert
    Institute of Medical Physics and Biophysics, University of Leipzig, Hartelstr 16 18, D 04107 Leipzig, Germany
    Glycobiology 22:134-45. 2012
    ..Our results highlight the importance of combining experimental and theoretical approaches to obtain a better understanding of the molecular recognition properties of GAG-protein systems...
  19. doi Nebulized hypertonic saline decreases IL-8 in sputum of patients with cystic fibrosis
    Emer P Reeves
    Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland
    Am J Respir Crit Care Med 183:1517-23. 2011
    ..Evidence that increased hypertonicity of airway secretions induced by hypertonic saline treatment alters levels of IL-8 is lacking...
  20. ncbi Interleukin-8 modulates growth and invasiveness of estrogen receptor-negative breast cancer cells
    Chen Yao
    Division of Breast Surgery, Department of Surgery, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, People s Republic of China
    Int J Cancer 121:1949-57. 2007
  21. pmc Increased expression of MMP-9 and IL-8 are correlated with poor prognosis of Bladder Cancer
    Sabrina Thalita Reis
    Urology Department, University of Sao Paulo Medical School, Sao Paulo, Brazil
    BMC Urol 12:18. 2012
    ..The purpose of this study was to investigate whether the expression of MMP-9, MMP-2 and its specific inhibitors, are expressed in a reproducible, specific pattern and if the profiles are related to prognosis in Bladder Cancer (BC)...
  22. ncbi IL-8 and IDO expression by human gingival fibroblasts via TLRs
    Rangsini Mahanonda
    Department of Periodontology, Faculty of Dentistry, Chulalongkorn University, Henry Dunant Road, Bangkok, Thailand
    J Immunol 178:1151-7. 2007
    ..Our results suggest an important role of HGFs not only in orchestrating the innate immune response, but also in dampening potentially harmful hyperactive inflammation in periodontal tissue...
  23. pmc Deregulation of a STAT3-interleukin 8 signaling pathway promotes human glioblastoma cell proliferation and invasiveness
    Nuria de la Iglesia
    Department of Pathology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 28:5870-8. 2008
    ..We also identify the chemokine interleukin 8 (IL8) as a novel target gene of STAT3 in human glioblastoma cells...
  24. ncbi The neutrophil-activating protein (NAP-1) is also chemotactic for T lymphocytes
    C G Larsen
    Laboratory of Molecular Immunoregulation, National Cancer Institute, Frederick, MD 21701
    Science 243:1464-6. 1989
    ..Intradermal injection of rNAP-1 caused dose-dependent accumulation of neutrophils and lymphocytes...
  25. ncbi Neutrophil elastase induces IL-8 gene transcription and protein release through p38/NF-{kappa}B activation via EGFR transactivation in a lung epithelial cell line
    Ippei Kuwahara
    Respiratory Immunology and Asthma Program, Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA
    Am J Physiol Lung Cell Mol Physiol 291:L407-16. 2006
    ..We conclude that NE increases IL-8 transcription through p38/NF-kappaB activation via EGFR transactivation...
  26. ncbi Simvastatin reduces expression of cytokines interleukin-6, interleukin-8, and monocyte chemoattractant protein-1 in circulating monocytes from hypercholesterolemic patients
    Abdolreza Rezaie-Majd
    Clinic of Internal Medicine II, Department of Angiology, University of Vienna, Vienna, Austria
    Arterioscler Thromb Vasc Biol 22:1194-9. 2002
    ..The anti-inflammatory effects of statins have recently been implicated in the clinical benefit that can be obtained in the treatment of atherosclerosis. Little is known about the mechanisms by which statins counteract inflammation...
  27. ncbi MCP-1, MIP-1, IL-8 and ischemic cerebral tissue enhance human bone marrow stromal cell migration in interface culture
    Lei Wang
    Department of Neurology, Henry Ford Health Sciences Center, Detroit, MI 48202, USA
    Hematology 7:113-7. 2002
    ..05). These data indicate that hMSCs are targeted by inflammatory chemotactic agents and cytokines and that ischemic brain attracts hMSCs...
  28. pmc Elevated miR-155 promotes inflammation in cystic fibrosis by driving hyperexpression of interleukin-8
    Sharmistha Bhattacharyya
    Department of Health Systems, Risk, and Contingency Management, Graduate School of Nursing, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    J Biol Chem 286:11604-15. 2011
    ..These data suggest that miR-155 may play an important role in the activation of IL-8-dependent inflammation in CF...
  29. pmc Interleukin-8 is activated in patients with chronic liver diseases and associated with hepatic macrophage accumulation in human liver fibrosis
    Henning W Zimmermann
    Department of Medicine III, University Hospital, Aachen, Germany
    PLoS ONE 6:e21381. 2011
    ..We investigated the regulation of IL-8, its receptors CXCR1 and CXCR2 and possible IL-8 responding cells in CLD patients...
  30. pmc Human IL-8 regulates smooth muscle cell VCAM-1 expression in response to endothelial cells exposed to atheroprone flow
    Nicole E Hastings
    Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA
    Arterioscler Thromb Vasc Biol 29:725-31. 2009
    ..We tested the hypothesis that IL-8 limits SMC VCAM-1 expression in response to inflammatory stimuli, either atheroprone flow or cytokine interleukin-1beta (IL-1beta) addition...
  31. doi Standardized tape stripping prior to patch testing induces upregulation of Hsp90, Hsp70, IL-33, TNF-α and IL-8/CXCL8 mRNA: new insights into the involvement of 'alarmins'
    Heinrich Dickel
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Contact Dermatitis 63:215-22. 2010
    ..It is under discussion whether the cutaneous inflammation induced by tape stripping is a pivotal element in enhancing the allergic contact dermatitis response...
  32. pmc Endothelial lipase (EL) and EL-generated lysophosphatidylcholines promote IL-8 expression in endothelial cells
    Monika Riederer
    Institute of Molecular Biology and Biochemistry, Harrachgasse 21 III, Medical University Graz, 8010 Graz, Austria
    Atherosclerosis 214:338-44. 2011
    ..In the present study, the impact of EL and EL-generated LPC on interleukin-8 (IL-8) synthesis was examined in vitro in primary human aortic endothelial cells (HAEC) and in mice...
  33. pmc The polymorphism interleukin 8 -251 A/T influences the susceptibility of Helicobacter pylori related gastric diseases in the Japanese population
    M Ohyauchi
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Seiryo machi, Aoba ku, Sendai, Miyagi 980 8574, Japan
    Gut 54:330-5. 2005
    ..Helicobacter pylori infection is associated with variable clinical outcomes, including gastroduodenal diseases, and genetic factors may be relevant in this process...
  34. pmc Mycobacterium abscessus glycopeptidolipid prevents respiratory epithelial TLR2 signaling as measured by HβD2 gene expression and IL-8 release
    Lisa B Davidson
    Department of Medicine, New Mexico Veterans Health Care System, Albuquerque, New Mexico, USA
    PLoS ONE 6:e29148. 2011
    ..abscessus colonization of abnormal lung airways escapes detection by the innate immune system...
  35. doi Helicobacter pylori CagA-mediated IL-8 induction in gastric epithelial cells is cholesterol-dependent and requires the C-terminal tyrosine phosphorylation-containing domain
    Chih Ho Lai
    Graduate Institute of Basic and Clinical Medical Science, School of Medicine, China Medical University, Taichung, Taiwan
    FEMS Microbiol Lett 323:155-63. 2011
    ..Our results suggest that CagA CTD-containing EPIYAs directly interact with cholesterol-rich microdomains that induce efficient IL-8 secretion in the epithelial cells...
  36. pmc Targeted knockdown of EGR-1 inhibits IL-8 production and IL-8-mediated invasion of prostate cancer cells through suppressing EGR-1/NF-kappaB synergy
    Jiajia Ma
    Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China
    J Biol Chem 284:34600-6. 2009
    ..Consequently, knockdown of EGR-1 inhibited IL-8-mediated tumor colony formation and invasion. Thus, targeted knockdown of EGR-1 could be an effective therapeutic approach against prostate cancer...
  37. ncbi Different affinities of glycosaminoglycan oligosaccharides for monomeric and dimeric interleukin-8: a model for chemokine regulation at inflammatory sites
    Birgit Goger
    Institute of Pharmaceutical Chemistry, Protein Chemistry and Biophysics Group, University of Graz, Universitatsplatz 1, A 8010 Graz, Austria
    Biochemistry 41:1640-6. 2002
  38. doi Increases of vitreous monocyte chemotactic protein 1 and interleukin 8 levels in patients with concurrent hypertension and diabetic retinopathy
    Yoshihiro Wakabayashi
    Department of Ophthalmology, Hachiouji Medical Center, Tokyo Medical University, Tokyo, Japan
    Retina 31:1951-7. 2011
    ..To investigate whether concurrent hypertension affects vitreous cytokine levels in diabetic retinopathy...
  39. doi Regulation of the p38 mitogen-activated protein kinase and dual-specificity phosphatase 1 feedback loop modulates the induction of interleukin 6 and 8 in cells infected with coronavirus infectious bronchitis virus
    Ying Liao
    School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore
    Virology 420:106-16. 2011
  40. ncbi Human neutrophil peptides induce interleukin-8 production through the P2Y6 signaling pathway
    Aye Aye Khine
    Department of Anaesthesia, St Michael s Hospital, Rm 7 007, Queen Wing, 30 Bond St, Toronto, Ontario M5B 1W8, Canada
    Blood 107:2936-42. 2006
    ..Transfection of lung epithelial cells with antisense oligonucleotides targeting specific purinergic P2Y receptors revealed that the P2Y6 (ligand of UDP) signaling pathway plays a predominant role in mediating HNP-induced IL-8 production...
  41. doi Adenosine modulates HIF-1{alpha}, VEGF, IL-8, and foam cell formation in a human model of hypoxic foam cells
    Stefania Gessi
    Chair of Pharmacology, Faculty of Medicine, University of Ferrara, Department of Clinical and Experimental Medicine, Pharmacology Unit, Via Fossato di Mortara 17 19, 44100 Ferrara, Italy
    Arterioscler Thromb Vasc Biol 30:90-7. 2010
    ..As hypoxia induces HIF-1alpha stabilization and adenosine (ado) accumulation, we investigated whether this nucleoside regulates HIF-1alpha in FCs...
  42. doi Proinflammatory cytokine IL-1beta stimulates IL-8 synthesis in mast cells via a leukotriene B4 receptor 2-linked pathway, contributing to angiogenesis
    Geun Young Kim
    School of Life Sciences and Biotechnology, Korea University, Seoul 136 701, Korea
    J Immunol 184:3946-54. 2010
  43. doi Macrophage migration inhibitory factor contributes angiogenesis by up-regulating IL-8 and correlates with poor prognosis of patients with primary nasopharyngeal carcinoma
    Bing Liao
    Department of Pathology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
    J Surg Oncol 102:844-51. 2010
    ..We aim at the association of macrophage migration inhibitory factor (MIF) with neovascularization and survival of nasopharyngeal carcinoma (NPC), and determine whether MIF is a valuable prognostic predictor for NPC patients...
  44. doi Lipopolysaccharide activated phosphatidylcholine-specific phospholipase C and induced IL-8 and MCP-1 production in vascular endothelial cells
    Lu Zhang
    Institute of Developmental Biology, School of Life Science, Shandong University, Jinan, China
    J Cell Physiol 226:1694-701. 2011
    ..PC-PLC might be a potential target for therapy in inflammation associated-diseases such as atherosclerosis...
  45. ncbi Activation of NF-kappaB and IL-8 by Yersinia enterocolitica invasin protein is conferred by engagement of Rac1 and MAP kinase cascades
    Guntram A Grassl
    Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Universitatsklinikum Tubingen, D 72076 Tubingen, Germany
    Cell Microbiol 5:957-71. 2003
    ..Our data identify Rac1 as a key intermediate in invasin-triggered IL-8 synthesis and demonstrate that maximum IL-8 induction involves several MAP kinase cascades...
  46. pmc HIV-1 gp120-mediated increases in IL-8 production in astrocytes are mediated through the NF-κB pathway and can be silenced by gp120-specific siRNA
    Ankit Shah
    Division of Pharmacology and Toxicology, UMKC School of Pharmacy, Kansas City, MO 64108, USA
    J Neuroinflammation 7:96. 2010
    ..In this study, we sought to address whether HIV-1gp120 could affect IL-8 expression in astrocytes and whether the NF-κB pathway is involved in this phenomenon...
  47. ncbi Increased serum interleukin-8 in patients with early and metastatic breast cancer correlates with early dissemination and survival
    Ina H Benoy
    Translational Cancer Research Group Antwerp, University of Antwerp, General Hospital Sint Augustinus, Wilrijk, Belgium
    Clin Cancer Res 10:7157-62. 2004
    ..The predictive value of serum IL-8 for the presence of occult metastatic tumor cells in bone marrow aspirates was evaluated in patients with operable and metastatic breast cancer...
  48. ncbi Platelet factor 4 and interleukin-8 CXC chemokine heterodimer formation modulates function at the quaternary structural level
    Irina V Nesmelova
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biol Chem 280:4948-58. 2005
    ..molecular modeling to provide direct evidence that tetrameric platelet factor-4 (PF4) and dimeric interleukin-8 (IL8), two members of the CXC chemokine family, readily interact by exchanging subunits and forming heterodimers via ..
  49. ncbi Interleukin-8 promoter polymorphism increases the risk of atrophic gastritis and gastric cancer in Japan
    Ayumu Taguchi
    Division of Gastroenterology, Department of Therapeutic Medicine, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya, Aichi, 466 8550 Japan
    Cancer Epidemiol Biomarkers Prev 14:2487-93. 2005
    ..In conclusion, we showed that the IL-8 -251 T > A polymorphism is associated with higher expression of IL-8 protein, more severe neutrophil infiltration, and increased risk of atrophic gastritis and gastric cancer...
  50. pmc Nox4 mediates renal cell carcinoma cell invasion through hypoxia-induced interleukin 6- and 8- production
    John P Fitzgerald
    Department of Urology, University of Texas Health Science Center, San Antonio, Texas, United States of America
    PLoS ONE 7:e30712. 2012
    ..AMP-activated protein kinase (AMPK) is a highly conserved sensor of cellular energy status and a role for AMPK in the regulation of cell inflammatory processes has recently been demonstrated...
  51. pmc Effect of interleukin-8 gene silencing with liposome-encapsulated small interfering RNA on ovarian cancer cell growth
    William M Merritt
    Department of Gynecologic Oncology, University of Texas M D Anderson Cancer Center, Houston, TX, USA
    J Natl Cancer Inst 100:359-72. 2008
    ..Interleukin-8 (IL-8) is a proangiogenic cytokine that is overexpressed in many human cancers. We investigated the clinical and biologic significance of IL-8 in ovarian carcinoma using human samples and orthotopic mouse models...
  52. pmc Interleukin-8 is associated with proliferation, migration, angiogenesis and chemosensitivity in vitro and in vivo in colon cancer cell line models
    Yan Ning
    Division of Medical Oncology, Sharon A Carpenter Laboratory, University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles, CA 90033, USA
    Int J Cancer 128:2038-49. 2011
    ..Together, these findings indicate that overexpression of IL-8 promotes tumor growth, metastasis, chemoresistance and angiogenesis, implying IL-8 to be an important therapeutic target in CRC...
  53. ncbi Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects
    Victoria Rotter
    Department of Internal Medicine, Lundberg Laboratory for Diabetes Research, The Sahlgrenska Academy, Goteborg University, SE 413 45 Goteborg, Sweden
    J Biol Chem 278:45777-84. 2003
    ..We conclude that IL-6 can play an important role in insulin resistance in man and, furthermore, that it may act in concert with other cytokines that also are up-regulated in adipose cells in insulin resistance...
  54. pmc Gingipains from Porphyromonas gingivalis increase the chemotactic and respiratory burst-priming properties of the 77-amino-acid interleukin-8 variant
    Irundika H K Dias
    School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, United Kingdom
    Infect Immun 76:317-23. 2008
    ..During periodontitis, secreted gingipains may differentially affect neutrophil chemotaxis and activation in response to IL-8 according to the cellular source of the chemokine...
  55. pmc Myeloid angiogenic cells act as alternative M2 macrophages and modulate angiogenesis through interleukin-8
    Reinhold J Medina
    Centre for Vision and Vascular Science, School of Medicine, Dentistry, and Biomedical Science, Queen s University Belfast, Belfast, UK
    Mol Med 17:1045-55. 2011
    ..We also show, for the first time, the true identity of these cells as alternative M2 macrophages with proangiogenic, antiinflammatory and pro-tissue-repair properties...
  56. ncbi Three-dimensional structure of interleukin 8 in solution
    G M Clore
    Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892
    Biochemistry 29:1689-96. 1990
    The solution structure of the interleukin 8 (IL-8) dimer has been solved by nuclear magnetic resonance (NMR) spectroscopy and hybrid distance geometry-dynamical simulated annealing calculations...
  57. doi Interleukin 8 and cardiovascular disease
    Stavros Apostolakis
    Laboratory of Clinical Virology, Faculty of Medicine, University of Crete, 71409 Heraklion, Crete, Greece
    Cardiovasc Res 84:353-60. 2009
    ..In the present review, the available evidence regarding the role of IL-8 in cardiovascular disease is presented, and future perspectives are discussed...
  58. ncbi The house dust mite allergen Der p 1, unlike Der p 3, stimulates the expression of interleukin-8 in human airway epithelial cells via a proteinase-activated receptor-2-independent mechanism
    Emmanuelle Adam
    Department of Applied Genetics, Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, B 6041 Gosselies, Belgium
    J Biol Chem 281:6910-23. 2006
    ..We conclude that Der p 1 (but not Der p 3)-induced IL-8 production in A549 epithelial cells is independent of PAR(2) activation...
  59. pmc Dachshund inhibits oncogene-induced breast cancer cellular migration and invasion through suppression of interleukin-8
    Kongming Wu
    Department of Cancer Biology, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 105:6924-9. 2008
    ..Collectively, our data identify a pathway by which an endogenous cell-fate determination factor blocks oncogene-dependent tumor metastasis via a key heterotypic mediator...
  60. pmc Genetic variations in angiogenesis pathway genes associated with clinical outcome in localized gastric adenocarcinoma
    G Lurje
    Division of Medical Oncology, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA
    Ann Oncol 21:78-86. 2010
    ..As such, proteinase-activated receptor (PAR)-1, endostatin (ES) and interleukin-8 (IL-8) mediate the regulation of early-onset angiogenesis and in turn impact the process of tumor-growth and disease progression...
  61. ncbi Angiogenic effects of interleukin 8 (CXCL8) in human intestinal microvascular endothelial cells are mediated by CXCR2
    Jan Heidemann
    Department of Medicine, Medical College of Wisconsin, Milwaukee 53226, USA
    J Biol Chem 278:8508-15. 2003
    ..The chemokine interleukin 8 (IL-8; CXCL8) exerts potent angiogenic properties on endothelial cells through interaction with its cognate ..
  62. doi Elevation of circulating interleukin-8 is related to lymph node and distant metastases in esophageal squamous cell carcinomas--implication for clinical evaluation of cancer patient
    Malgorzata Krzystek-Korpacka
    Department of Medical Biochemistry, Silesian Piasts University of Medicine, ul Chalubinskiego 10, 50 368 Wroclaw, Poland
    Cytokine 41:232-9. 2008
    ..Yet, the detection rates were not satisfactory enough to allow for the recommendation of IL-8 determination as an adjunct to the clinical evaluation of lymph node involvement in ESCC patients...
  63. ncbi Regulation of the immune response by the interaction of chemokines and proteases
    Sofie Struyf
    Laboratory of Molecular Immunology, Rega Institute for Medical Research, Minderbroedersstraat 10, University of Leuven, B 3000 Leuven, Belgium
    Adv Immunol 81:1-44. 2003
  64. pmc Interleukin-8, a promising predictor for prognosis of pancreatic cancer
    Ying Chen
    Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
    World J Gastroenterol 18:1123-9. 2012
    ..To investigate the value of interleukin-8 (IL-8), a pro-inflammatory chemokine, in predicting the prognosis of pancreatic cancer...
  65. doi An environmental contaminant, benzo(a)pyrene, induces oxidative stress-mediated interleukin-8 production in human keratinocytes via the aryl hydrocarbon receptor signaling pathway
    Gaku Tsuji
    Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Dermatol Sci 62:42-9. 2011
    ..Although BaP has been shown to exert its biological effects via the aryl hydrocarbon receptor (AhR) signaling pathway, the mechanism of its inflammatory effects on skin remains unanswered...
  66. pmc NFκB and AP-1 drive human myometrial IL8 expression
    Shirin Khanjani
    Parturition Research Group, Institute of Reproductive and Developmental Biology, Imperial College London, London W12 0NN, UK
    Mediators Inflamm 2012:504952. 2012
    The uterine expression of the chemokine IL8 increases dramatically with the onset of labour both at term and preterm...
  67. doi Secretion of IL-6 and IL-8 from lysophosphatidic acid-stimulated oral squamous cell carcinoma promotes osteoclastogenesis and bone resorption
    Young Sun Hwang
    Oral Cancer Research Institute, Yonsei University College of Dentistry, Republic of Korea
    Oral Oncol 48:40-8. 2012
    ..LPA-induced IL-6 and IL-8 exerted propound effects on RANKL expression in osteoblast and thereby promoted osteoclast formation from osteoclast precursors...
  68. ncbi Functional promoter region polymorphism of the proinflammatory chemokine IL-8 gene associates with Parkinson's disease in the Irish
    Owen A Ross
    Department of Geriatric Medicine, Belfast, Ireland
    Hum Immunol 65:340-6. 2004
  69. ncbi IL-8 expression by biliary epithelial cells is associated with neutrophilic infiltration and reactive bile ductules
    Kumiko Isse
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Liver Int 27:672-80. 2007
    ..Recently, biliary epithelial cells have been shown to secrete cytokines and chemokines and to express components of the mucosal immune system such as Toll-like receptors...
  70. pmc Modulation of cystic fibrosis lung disease by variants in interleukin-8
    A D Hillian
    Department of Genetics, Case Western Reserve University, Cleveland, OH 44106 4948, USA
    Genes Immun 9:501-8. 2008 three inflammatory genes showed significant genotypic associations with CF lung disease severity, including IL8 and previously reported TGFbeta1 (P< or =0.05)...
  71. ncbi Receptors involved in the oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine-mediated synthesis of interleukin-8. A role for Toll-like receptor 4 and a glycosylphosphatidylinositol-anchored protein
    Kimberly A Walton
    Department of Medicine, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 278:29661-6. 2003
    ..Therefore, these studies suggest that ox-PAPC may initially bind to a 37-kDa GPI-anchored protein, which interacts with TLR4 to induce IL-8 transcription...
  72. doi Cytokines in bronchoalveolar lavage fluid and serum of lung cancer patients during radiotherapy - Association of interleukin-8 and VEGF with survival
    Marika Crohns
    Department of Oncology, University of Tampere, Tampereen yliopisto, Finland
    Cytokine 50:30-6. 2010
    ..The increase of BAL fluid IL-6 during RT might be attributed to enhanced RT-related oxidative stress or increased cell death. Serum and BAL fluid IL-8 and serum VEGF might have a prognostic role in survival of lung cancer...
  73. ncbi Interleukin-8 as a macrophage-derived mediator of angiogenesis
    A E Koch
    Department of Medicine, Northwestern University Medical School, Chicago, IL 60611
    Science 258:1798-801. 1992
    ..These data suggest a function for macrophage-derived IL-8 in angiogenesis-dependent disorders such as rheumatoid arthritis, tumor growth, and wound repair...
  74. pmc Induction of TLR-2 and TLR-5 expression by Helicobacter pylori switches cagPAI-dependent signalling leading to the secretion of IL-8 and TNF-α
    Suneesh Kumar Pachathundikandi
    Institute for Medical Microbiology, Otto von Guericke University, Magdeburg, Germany
    PLoS ONE 6:e19614. 2011
    ..pylori-induced expression of TLR-2 and TLR-5 can qualitatively shift cagPAI-dependent to cagPAI-independent pro-inflammatory signalling pathways with possible impact on the outcome of H. pylori-associated diseases...
  75. ncbi IL-8 as antibody therapeutic target in inflammatory diseases: reduction of clinical activity in palmoplantar pustulosis
    Lone Skov
    Department of Dermatology, Copenhagen University Hospital Gentofte, Hellerup, Denmark
    J Immunol 181:669-79. 2008
    ..HuMab 10F8 is capable of interrupting IL-8 activity in vivo and represents a candidate for treatment of inflammatory diseases and other pathological conditions associated with IL-8 overproduction...
  76. pmc Citrullination of CXCL8 by peptidylarginine deiminase alters receptor usage, prevents proteolysis, and dampens tissue inflammation
    Paul Proost
    Laboratory of Molecular Immunology, Rega Institute, K U Leuven, Leuven, Belgium
    J Exp Med 205:2085-97. 2008
    ..This study shows that PAD citrullinates the chemokine CXCL8, and thus may dampen neutrophil extravasation during acute or chronic inflammation...
  77. pmc Helicobacter pylori induces interleukin-8 secretion by Toll-like receptor 2- and Toll-like receptor 5-dependent and -independent pathways
    Anastasia M Torok
    University of Virginia Health System, P O Box 800734, Charlottesville, VA 22908 0734, USA
    Infect Immun 73:1523-31. 2005
    ..pylori induces IL-8 secretion through a dual mechanism that includes a TLR2/5-independent component involving the activities of JNK and ERK and a TLR2/5-dependent component that requires p38 activity...
  78. pmc A20 is an early responding negative regulator of Toll-like receptor 5 signalling in intestinal epithelial cells during inflammation
    N Oshima
    Department of Internal Medicine II, Shimane University School of Medicine, Izumo, Shimane, Japan
    Clin Exp Immunol 159:185-98. 2010
    ..Our results provide new insights into the negative feedback regulation of TLR-5 signalling that maintains the innate immune system in the gut...
  79. pmc Correlation of IL-8 with induction, progression and metastatic potential of colorectal cancer
    Claudia Rubie
    Labor fur Allgemein, Viszeral, GefaSS und Kinderchirurgie, Universitatsklinikum des Saarlandes, Chirurgische Klinik, Gebaude 57, Homburg 66421, Germany
    World J Gastroenterol 13:4996-5002. 2007
    ..To investigate the expression profile of IL-8 in inflammatory and malignant colorectal diseases to evaluate its potential role in the regulation of colorectal cancer (CRC) and the development of colorectal liver metastases (CRLM)...
  80. ncbi The role of interleukin-8 in cancer cells and microenvironment interaction
    Ang Yuan
    Department of Clinical Research and Internal Medicine, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan 100, ROC
    Front Biosci 10:853-65. 2005
  81. pmc Mechanisms underlying differential expression of interleukin-8 in breast cancer cells
    Ariane Freund
    INSERM U540 Molecular and Cellular Endocrinology of Cancers, 60, rue de Navacelles, 34090 Montpellier, France
    Oncogene 23:6105-14. 2004
  82. ncbi Prognostic value of serum level of interleukin-6 and interleukin-8 in metastatic breast cancer patients
    Olal I Ahmed
    Department of Microbiology and Immunology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
    Egypt J Immunol 13:61-8. 2006
    ..Thus, it could be concluded that serum level of IL-6 and IL-8 are useful prognostic factors in metastatic breast cancer patients...
  83. doi Interleukin(IL)-4 promotion of CXCL-8 gene transcription is mediated by ERK1/2 pathway in human pulmonary artery endothelial cells
    Dao Feng Yang
    Department of Respiratory Diseases, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, Wuhan 430030, China
    Mol Immunol 48:1784-92. 2011
    ..ERK1/2, rather than NF-κB, JNK and p38 MAPK signaling, plays a role in IL-4 induced chemokine activation. Our results suggest that inhibition of ERK1/2 may be a possible target for airway neutrophilia in allergic lung diseases...
  84. pmc IL-8 signaling plays a critical role in the epithelial-mesenchymal transition of human carcinoma cells
    Romaine I Fernando
    Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA
    Cancer Res 71:5296-306. 2011
    ..Our results also indicate the essential role of interleukin 8 (IL-8) signaling for the acquisition and/or maintenance of the mesenchymal and invasive features of Brachyury-..
  85. doi CD133(+) liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signaling
    Kwan Ho Tang
    Department of Pathology, Li Ka Shing Faculty of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Hepatology 55:807-20. 2012
    ..Further, in its role as a liver TIC marker CD133 also plays a functional part in regulating tumorigenesis of liver TICs by way of regulating NTS, IL-8, CXCL1, and MAPK signaling...
  86. ncbi Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis
    Anke Sparmann
    Graduate Program in Molecular Genetics and Microbiology, State University of New York at Stony Brook, Stony Brook, New York 11794, USA
    Cancer Cell 6:447-58. 2004
    ..Collectively, our data identify a novel mechanism by which the Ras oncogene can elicit a stromal response that fosters cancer progression...
  87. doi Steroid-insensitive ERK1/2 activity drives CXCL8 synthesis and neutrophilia by airway smooth muscle
    Stephanie Robins
    Meakins Christie Laboratories, McGill University Heath Centre Research Institute, Montreal, Canada
    Am J Respir Cell Mol Biol 45:984-90. 2011
  88. doi Interleukin 8 and susceptibility to coronary artery disease: a population genetics perspective
    Konstantina Vogiatzi
    Laboratory of Clinical Virology, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece
    J Clin Immunol 28:329-35. 2008
    b>Interleukin 8 is a strong chemoattractant factor for neutrophils and T lymphocytes...
  89. pmc DNA promoter methylation status and protein expression of interleukin-8 in human colorectal adenocarcinomas
    Jan Dimberg
    Department of Natural Science and Biomedicine, University College of Health Sciences, SE 551 11, Jonkoping, Sweden
    Int J Colorectal Dis 27:709-14. 2012
    ..DNA methylation of cytosine residues in CpG dinucleotides leads to transcriptional silencing of associated genes...
  90. ncbi The -251T allele of the interleukin-8 promoter is associated with increased risk of gastric carcinoma featuring diffuse-type histopathology in Chinese population
    Wei Ping Lee
    Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taiwan
    Clin Cancer Res 11:6431-41. 2005
    ..Particularly, the -251A is associated with decreased risk of colorectal cancer. We aimed to determine whether the -251 allele resulting in high IL-8 expression was associated with increased risk of gastric carcinoma...
  91. ncbi IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis
    Aihua Li
    Department of Pathology and Microbiology, University of Nebraska Medical Center, 987660 Nebraska Medical Center, Omaha, NE 68198, USA
    J Immunol 170:3369-76. 2003
    ..Our data suggest that IL-8 directly enhanced endothelial cell proliferation, survival, and MMP expression in CXCR1- and CXCR2-expressing endothelial cells and regulated angiogenesis...
  92. pmc Potentiation of inflammatory CXCL8 signalling sustains cell survival in PTEN-deficient prostate carcinoma
    Pamela J Maxwell
    Centre for Cancer Research and Cell Biology, Queen s University Belfast, Belfast, Northern Ireland
    Eur Urol 64:177-88. 2013
    ..Inactivation of the tumour suppressor gene phosphatase and tensin homolog (PTEN) is prevalent in early PCa. The relationship of PTEN deficiency to inflammatory signalling remains to be characterised...
  93. pmc Peroxisome proliferator-activated receptor {delta} activators induce IL-8 expression in nonstimulated endothelial cells in a transcriptional and posttranscriptional manner
    Markus Meissner
    Department of Dermatology, Johann Wolfgang Goethe Universitat, D 60590 Frankfurt am Main, Germany
    J Biol Chem 285:33797-804. 2010
    ..Therefore, our data provide the first evidence that PPARδ induces IL-8 expression in nonstimulated endothelial cells via transcriptional as well as posttranscriptional mechanisms...
  94. pmc Src homology-2 domain-containing protein tyrosine phosphatase (SHP) 2 and p38 regulate the expression of chemokine CXCL8 in human astrocytes
    Manmeet K Mamik
    Department of Cell Biology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX, USA
    PLoS ONE 7:e45596. 2012
    ..This study provides detailed understanding of the mechanisms involved in CXCL8 production during neuroinflammation...
  95. ncbi Potential involvement of IL-8 and its receptors in the invasiveness of pancreatic cancer cells
    Yukio Kuwada
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734 8551, Japan
    Int J Oncol 22:765-71. 2003
    ..These results demonstrate that IL-8 and IL-8 receptors are over-expressed in pancreatic cancer, and suggest that IL-8 regulates MMP-2 activity and plays an important role in the invasiveness of human pancreatic cancer...
  96. ncbi Transcriptional regulation of IL-8 by iron chelator in human epithelial cells is independent from NF-kappaB but involves ERK1/2- and p38 kinase-dependent activation of AP-1
    Eun Young Choi
    Department of Life Science, Gwangju Institute of Science and Technology GIST, Gwangju, Korea
    J Cell Biochem 102:1442-57. 2007
    ..A possible link between iron status and two additional transcription factors, that is, CREB and Egr-1, rather than NF-kappaB, was also suggested...
  97. doi Association of haplotypes in the IL8 gene with susceptibility to chronic periodontitis in a Brazilian population
    Yeon Jung Kim
    Departamento de Diagnóstico e Cirurgia, Faculdade de Odontologia de Araraquara, Unesp Univ Estadual Paulista, SP, Brazil
    Clin Chim Acta 411:1264-8. 2010
    b>Interleukin 8 (IL-8) is a chemokine related to the initiation and amplification of acute and chronic inflammatory processes. Polymorphisms in the IL8 gene have been associated with inflammatory diseases...
  98. doi Pseudomonas aeruginosa induces interleukin-8 (IL-8) gene expression in human conjunctiva through the recruitment of both RelA and CCAAT/enhancer-binding protein beta to the IL-8 promoter
    Isabella Venza
    Departments of Surgical Specialties and Experimental Pathology and Microbiology, University of Messina, 98125 Messina, Italy
    J Biol Chem 284:4191-9. 2009
  99. doi Haplotypes of susceptibility to chronic periodontitis in the Interleukin 8 gene do not influence protein level in the gingival crevicular fluid
    Sâmia C T Corbi
    Department of Oral Diagnosis and Surgery, School of Dentistry at Araraquara, UNESP Sao Paulo State University, Araraquara, SP, Brazil
    Arch Oral Biol 57:1355-61. 2012
    ..The aim of the study was to investigate whether the IL8 haplotype ATC/TTC was associated with the volume of gingival crevicular fluid (GCF), the concentration of ..
  100. pmc Stress effects on FosB- and interleukin-8 (IL8)-driven ovarian cancer growth and metastasis
    Mian M K Shahzad
    Department of Gynecologic Oncology, RNA, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 285:35462-70. 2010
    ..Our recent findings suggest that chronic stress is associated with increased IL8 levels. Here, we examined the molecular and biological significance of IL8 in stress-induced tumor growth...
  101. doi Association of matrix metalloproteinase (MMP)-1, 3, 9, interleukin (IL)-2, 8 and cyclooxygenase (COX)-2 gene polymorphisms with chronic periodontitis in a Chinese population
    Guangyue Li
    State Key Laboratory for Oral Diseases and Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, PR China
    Cytokine 60:552-60. 2012
    ..MMP-1-1067 2G, MMP-3-1171 6A, MMP-9-1562 T and IL-8-251 A allele are associated with decreased susceptibility to CP in Chinese population...

Research Grants62

  1. Proinflammatory Biomarkers and Post-Breast CancerLymphedema
    Mei Rosemary Fu; Fiscal Year: 2012
    ..and candidate genes include lymphatic specific growth factors (VEGF-C &VEGF-D), cytokines (IL1-a, IL1-b, IL6, IL8, &IL10), and tumor necrosis factor-a...
  2. Neuroimaging abnormalities in major depressive disorder: effect of inflammation
    Jonathan Savitz; Fiscal Year: 2013
    ..A post-hoc analysis with additional, commonly measured cytokines: IN?, IL2, IL4, IL5, IL1[unreadable], IL8, TNF[unreadable], and IL12p70 (hereafter bead array: BA cytokines) will also be conducted...
  3. Interactions of Diesel Exhaust and Respiratory Viruses in Asthmatic Children
    Toby C Lewis; Fiscal Year: 2013
    ..2 million people in the United States, thus pointing the way towards targeted therapies and public health approaches. ..
  4. The role of polyamine oxidase in antitumor drug response
    Robert A Casero; Fiscal Year: 2013
    ..ETBF), and exposure to the general mediators of inflammation, TNF[unreadable], IL-1[unreadable] IL-6, &IL8. Both H. pylori and B. fragilis are implicated in inflammation associated cancers, gastric and colon, respectively...
  5. Inflammation Pathways in Breast Cancer
    Margaret M Madeleine; Fiscal Year: 2010
    ..We will evaluate whether polymorphisms in proinflammatory (IL1, IL6, IL8, IL12, TNF, and leptin) and anti- flammatory (IL1RN, IL2, IL10, adiponectin) genes and their receptors alter the ..
  6. Antiphospholipid antibodies and lupus: new molecular targets for treatment
    Emilio B Gonzalez; Fiscal Year: 2013
    ..adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), upregulation of cytokines [IL1b, IL6, IL8, TNF-a, vascular endothelial growth factor (VEGF)]...
  7. Ras and Chemokine Stimulated Neutrophil Polarization
    Cindy Knall; Fiscal Year: 2004
    ..The chemokines Interleukin-8 (IL8) and Growth-Regulated Oncogene alpha (GROalpha) control much of the normal function of neutrophils...
  8. Genetic susceptibility to gastric cancer in Latin America
    Eduardo M Tarazona-Santos; Fiscal Year: 2011
    ..This response is mediated by the Toll-like-receptors, pro-inflammatory cytokines such as interleukin-8 (IL8), 1L-1? and TNF-?, and the pro-inflammatory enzyme COX-2...
  9. Cytokine Polymorphisms and Cancer Related Pain
    Cielito Reyes Gibby; Fiscal Year: 2009
    ..Our preliminary data (n=514) supporting our hypothesis on the important role of cytokine genes (IL8) on pain severity have recently been accepted for publication...
  10. IL8-induced Post-transcriptional Regulation of the MUC5AC mucin gene
    Mary C Rose; Fiscal Year: 2010
    ..The inflammatory mediator IL8 stabilizes MUC5AC mRNA abundance in lung cells and regulates MUC5AC at the post-transcriptional level...
  11. Targeted Delivery of iPS-Endothelial Cells for the Repair of Cardiovascular Injur
    Yiu Fai Chen; Fiscal Year: 2013
    ..v. transfusing endothelial cells (ECs) overexpressing neutrophil interleukin-8 (IL8) receptors into rats with endoluminal injury of the carotid artery or myocardial infarction...
  12. Scientific Basis of Iodine-Fluoride Varnish in Preventing Dental Caries
    R MIKE SHIRTCLIFF; Fiscal Year: 2013
    ..the technical and scientific feasibility of using a combination povidone-iodine (PVP-I)-5% sodium fluoride (NaF) varnish as a potential commercial product to prevent dental caries...
  13. Disparities in Breast Cancer: Development and Survival in Hispanic and NHW Women
    Martha L Slattery; Fiscal Year: 2013
    ..include SOC1, SOC2, AKT, FRAP1(alias mTOR), P13K, STK11, AMP, PTEN, VEGF, &S6K1,S6K2, CRP, NFKB, IKB, IL10, IL8, IL6, TNFalpha using an Illumina platform...
  14. Diet, Activity, and Lifestyle as a Risk Factor for Colorectal Cancer
    Martha L Slattery; Fiscal Year: 2012
    ..known functional polymorphisms and evaluate haplotypes in candidate genes in an inflammation-related pathway (IL6, IL8, IL10, NFKB, TNF-A, IL4, IL1, ILIRA and IFNG) and genes located at key junctions where other cellular signaling ..
    JARVIS CHAN; Fiscal Year: 1990
    ..We have shown for the first time that concomitant ingestion of sodium fluoride (NaF) and MX or MX-containing beverages by rats resulted in plasma level significantly higher than that by ingestion of ..
  16. Pathophysiology of Biliary Disease
    Nicholas F Larusso; Fiscal Year: 2013
    ..phenotype (SASP) characterized by excessive expression and release of proinflammatory mediators, including IL6 and IL8;and (v) liver tissue from patients with PSC exhibits an increased proportion of cholangiocytes with the senescent ..
  17. The role of colitic stem cell niche in oncogenesis
    EMINA HUI NA HUANG; Fiscal Year: 2013
    ..Aim 3) To show the key contribution of IL8 / UC stroma to epithelial proliferation...
  18. The role of IL8 in colitis-associated tumor initiation
    EMINA HUI NA HUANG; Fiscal Year: 2013
    ..The objective of this particular application is to determine how autocrine IL8 contributes to the tumorigenicity of colitis-derived colon cancer initiating cells (CCICs)...
  19. Rel B mediated-redox regulation of radiation therapy
    William H St Clair; Fiscal Year: 2013
    ..levels;2) suppression of RelB in androgen independent-aggressive prostate cancer cells results in reduction of interleukin 8 (IL8) levels in tumor cells and reduced tumor growth in vivo;3) overexpression of RelB in androgen responsive ..
  20. Molecular Markers of Risk, Phenotype, and Outcomes in ARDS
    Ednan K Bajwa; Fiscal Year: 2012
    ..for ARDS to: (1) determine the role of variation in genes in the PBEF pathway (PBEF, NFKB1, MAPK14, CASP3, MYLK, IL8)in ARDS risk and outcomes;(2) to to determine the role of diabetes, hyperglycemia, and insulin therapy in ARDS risk ..
  21. The NFkB-dependent Secretome and Invasion/Angiogenesis in Thyroid Cancer
    Bryan R Haugen; Fiscal Year: 2013
    ..define the NFkB-dependent secretome in advanced thyroid cancer, (3) Genetic and functional manipulation of interleukin 8, identified as an important NFkB-dependent secreted protein in thyroid cancer, and other identified NFkB ..
    Azad Bonni; Fiscal Year: 2013
    ..We have also found that STAT3 represses IL8 transcription in PTEN-deficient glioblastoma cells and thereby inhibits their proliferation and invasiveness...
  23. Arizona/Duke Clinical Center for AsthmaNet
    Fernando D Martinez; Fiscal Year: 2013
    ..such exacerbations, and if this preventive effect is specific for carriers of a genotype in a polymorphism in IL8 (IL8/-159 AA), which we have shown is associated with increased risk of neutrophilic exacerbations...
  24. Identifying Peripheral Blood Biomarkers for Idiopathic Pulmonary Fibrosis
    LOUIS JUSTINE VUGA; Fiscal Year: 2013
    ..More recently we found an outcome predictive signature that included MMP7, IL8, S100A12 among others...
  25. Plasma Biomarkers of Acute Graft Versus Host Disease
    James L M Ferrara; Fiscal Year: 2013
    ..We have recently evaluated six previously validated diagnostic biomarkers of GVHD (IL2R?, TNFR1, HGF, IL8, elafin, and REG3?, for their ability to predict which patients would respond to therapy and who would achieve long ..
    Edmund Miller; Fiscal Year: 2001
    Denis English; Fiscal Year: 1990
    ..Prior to the initiation of intracellular Ca++ increases, 20 mM NaF effected rapid disappearance of cellular PIP2...
  28. PA-50/PA-41 antitoxin antibody therapy for C. difficile infection
    William C Olson; Fiscal Year: 2012
    ..with first-generation mAbs, PA-50 and PA-41 are 1,000-fold more potent in neutralizing toxins from virulent BI/NAP1/027 strains in vitro...
  29. Laboratory and clinical evaluation of prospective fluoride rinses containing TCP-
    Robert L Karlinsey; Fiscal Year: 2012 the NIDCR that addresses the following Specific Aims: 1) Evaluation of stability and in vitro efficacy of NaF mouthrinse formulations containing TCP-SLS...
    Laurence Chow; Fiscal Year: 2009
    ..2) an in vivo saliva and plaque model to compare oral F retention produced by the nano CaF2 and currently used NaF rinses, and (3) an in situ demineralization/remineralization model to evaluate the remineralization effects of the ..
  31. Role of Angiogenic CXC Chemokines in Intramembranous Bone Repair
    Dean T Yamaguchi; Fiscal Year: 2013
  32. Evaluation of a new class of antimicrobial agents against Clostridium difficile
    SAUL R contact TZIPORI; Fiscal Year: 2011
    ..abstract_text> ..
  33. Fluoride Agents: Pattern of their Effect on Early Caries
    Bennett Amaechi; Fiscal Year: 2005
    ..2 months, the subject will receive either of 4 treatment modalities; (V2) high fluoride concentration varnish (5% NaF), (V1) low fluoride concentration varnish (0...
    FLORIAN CERKLEWSKI; Fiscal Year: 1991
    ..These studies provided new information because the dietary fluoride levels (2 or 10 ppm as NaF) represented nutrition rather than fluorosis unlike previous studies by others...
    Steven Levy; Fiscal Year: 1991
    ..05% NaF mouthrinse in the arresting and reversal of incipient root caries lesions...
    RICHARD CORPRON; Fiscal Year: 1993
    ..2mg FRD, 2) 1.Omg FRD, 3) NaF dentifrice brushed 2X/day, and 4) 1.Omg FRD plus NaF dentifrice 2X/day...
  37. Nontoxigenic Clostridium difficile as an Oral Vaccine for C. difficile Infection
    DALE NICHOLAS GERDING; Fiscal Year: 2013
    ..An epidemic strain, BI/NAP1/027, is contributing to the outbreak of CDI...
  38. A fully integrated assay and platform for detecting Clostridium difficile
    BRUCE D IRVINE; Fiscal Year: 2010
    ..difficile, BI/NAP1, has a single point mutation in this gene that results in a premature stop codon...
  39. Transduction of T cells to improve migration to tumor
    Patrick Hwu; Fiscal Year: 2013
    ..This may enable improved immune therapies for melanoma and other cancers. ..
  40. Clinical Significance of Clostridium difficile Toxin Variants
    STUART BRIAN JOHNSON; Fiscal Year: 2012
    ..S. have been linked to the emergence of a specific C. difficile toxin variant, referred to as BI/NAP1/027 which may explain, at least in part, the overall increase in national rates of CDAD...
  41. Effect of Rhinovirus on airway epithelial reciprocal pathways influence NK cells.
    Jonathan Koff; Fiscal Year: 2013
    ..This proposal will investigate the signaling pathways of airway epithelial responses to Rhinovirus infection, and the discovery of novel mechanisms may provide targets for future therapies. ..
  42. The relative contribution of TcdA and TcdB to C. difficile associated disease
    Jennifer A Steele; Fiscal Year: 2010
    ..In Aim 1, a set of isogenic C. difficile toxin mutants will be created from the human epidemic 027/NAP1/BI strain. The mutants will be created using two recently developed methods for genetic manipulation in C...
    DAVID WILLIAM MARTIN; Fiscal Year: 2013
    ..The lead candidate, termed a "diffocin", kills 27 of a collection of 28 BI/NAP1/027 strains;and Lawley et al (2010) have described a mouse model of C. difficile carriage...
  44. Development of Novel Inhibitors of Clostridium difficile.
    Jane Ryan; Fiscal Year: 2013
    ..Biota's novel FtsZ inhibitor compounds possess potency against C. difficile, including the hypervirulent BI/NAP1/027 strain which now appears to be emerging in wider populations...
  45. Immunopathogenesis of Adenovirus Keratitis
    James Chodosh; Fiscal Year: 2013
    ..As adenoviruses represent the most common cause of eye infections, this proposal will address a major public health concern. ..
  46. CXCL8-mediated glial cross-talk and neuroprotection in HIV-1 Dementia
    Anuja Ghorpade; Fiscal Year: 2013
    ..abstract_text> ..
  47. Regulation of Borealin Function by Mitotic Phosphorylation
    William Taylor; Fiscal Year: 2009
    ..of Borealin also occurs when cells blocked in S-phase are exposed to the broad spectrum phosphatase inhibitor NaF. This suggests that a labile phosphatase keeps Borealin dephosphorylated during interphase, and that inactivation ..
  48. srGAP and the cadherin complex during morphogenesis in C. elegans
    JEFFREY D HARDIN; Fiscal Year: 2013
    ..elegans Sra-1/Nap1/Abi complex, and MIG-10/lamellipodin interact with the homologous region of SRGP-1...
  49. Intercellular adhesion and morphogenesis: role of actin-regulatory proteins
    Ann Marie Pendergast; Fiscal Year: 2010
    ..We have shown that the Abi/Nap1 complex is required for the formation and stability of cell-cell contacts, and that Abi exists in distinct protein ..
  50. Clinical Research Consortium for Spinocerebellar Ataxias
    Tetsuo Ashizawa; Fiscal Year: 2010
    ..from the United States, to establish a multidisciplinary network, and integrate the National Ataxia Foundation (NAF), Bob Allison Ataxia Research Center (BAARC), NINDS, and the industry (Medical Marveric) to accomplish these ..
  51. Evaluation of C. difficile Severity in Epidemiologic Studies &in Animal Models
    LAURIE R ARCHBALD-PANNONE; Fiscal Year: 2012
    ..CDAD epidemics and community acquisition suggest that the nature of CDAD is changing. Toxinotype III, NAP1/027/BI strains (BI), although present since 1984, now have quinolone resistance, and they have been associated with ..
  52. Development of Face Processing in Infants with Autism Spectrum Disorders
    Katarzyna Chawarska; Fiscal Year: 2013
    ..will afford the division of the population into three groups: 1) siblings with ASD;2) Non-Affected siblings (NAF);and 3) siblings with various developmental delays but without ASD features (DD)...
    Lucy F Pemberton; Fiscal Year: 2010
    ..This project builds from previous observations that the yeast histone chaperone Nap1 p is a histone nuclear import factor...
  54. Structure-Activity Relationship of CM101 Tumor antiangiogenic agent with its lect
    BETTY CHOURONG ZHU; Fiscal Year: 2012
  55. The chaperone function of Nucleosome Assembly Protein 1
    DANIEL KRZIZIKE; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Nucleosome assembly protein 1 (Nap1) is a histone chaperone implicated in histone regulation through interactions with core histones and linker histone H1, as well as in nucleosome formation and gene ..
    Ho Leung Fung; Fiscal Year: 1980
    ..75 plus or minus 0.08; n equals 7, p less then 0.10) or 0.02 M NaF (1.20 plus or minus 0.20; n equals 7, p less then 0.02)...
    Christin Carter Su; Fiscal Year: 1993
    WILFRED ARNOLD; Fiscal Year: 1990
    ..The "isoenzymes" are also distinguished by different responses to inhibitors (NaF, phosphate and tartrate). On a special growth medium we can 'force' yeastlike cells at 20 degrees C, i.e...
  59. Pregnancy Estrogens, Diet, and Breast Cancer Risk
    Leena Hilakivi Clarke; Fiscal Year: 2005
    ..Growth factor levels will be measured in nipple aspirate fluid (NAF) that can be obtained using a breast pump from non-lactating breast...
    Carl Weiner; Fiscal Year: 2005
    ..obtained from pregnant, nonpregnant, and estrogen or progesterone-treated castrate animals before and after NaF activation...
  61. Modulation of nucleosome dynamics
    ANDREW ANDREWS; Fiscal Year: 2009
    ..I propose to use Nucleosome Assembly Protein 1 (NAP1) as a means to control free histone concentrations, to measure the affinity and cooperativity of histone dimers and ..
    Mustafa Lokhandwala; Fiscal Year: 2003
    ..Gs and Gq/11) will be quantified by western blotting and their function measured using various agents such as GTP, NaF and a comparison will be made between adult and old rats...