IL-6

Summary

Gene Symbol: IL-6
Description: interleukin 6
Alias: BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2, IFNB2, IL-6, interleukin-6, B-cell differentiation factor, B-cell stimulatory factor 2, CTL differentiation factor, hybridoma growth factor, interferon beta-2, interleukin BSF-2
Species: human

Top Publications

  1. ncbi IL-6 in autoimmune disease and chronic inflammatory proliferative disease
    Katsuhiko Ishihara
    Department of Molecular Oncology C7, Graduate School of Medicine, Osaka University, 2 2 Yamada Oka Suita, Osaka 565 0871, Japan
    Cytokine Growth Factor Rev 13:357-68. 2002
  2. ncbi Interleukin-6 genetic variability and adiposity: associations in two prospective cohorts and systematic review in 26,944 individuals
    Lu Qi
    Departments of Nutrition and Epidemiology, Harvard School of Public Health, and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 92:3618-25. 2007
  3. doi Genetic polymorphisms in non-alcoholic fatty liver disease: interleukin-6-174G/C polymorphism is associated with non-alcoholic steatohepatitis
    L Carulli
    Dipartimento di Medicina, Endocrinologia, Metabolismo e Geriatria, Nuvo Ospedale Civile S Agostino Estense, Via Giardini 1355, 41100 Modena, Italy
    Dig Liver Dis 41:823-8. 2009
  4. pmc Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion
    Dimitrios Iliopoulos
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:1397-402. 2011
  5. pmc Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
    Francis Rodier
    Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
    Nat Cell Biol 11:973-9. 2009
  6. ncbi Interleukin 6 induces the expression of vascular endothelial growth factor
    T Cohen
    Department of Food Engineering and Biotechnology, Technion, Israel Institute of Technology, Haifa, Israel
    J Biol Chem 271:736-41. 1996
  7. pmc Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells
    N J Sullivan
    Integrated Biomedical Science Graduate Program, College of Medicine, The Ohio State University, Columbus, OH 43210, USA
    Oncogene 28:2940-7. 2009
  8. ncbi Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin
    T Hirano
    Nature 324:73-6. 1986
  9. ncbi HIV-1 Tat induces the expression of the interleukin-6 (IL6) gene by binding to the IL6 leader RNA and by interacting with CAAT enhancer-binding protein beta (NF-IL6) transcription factors
    C Ambrosino
    Department of Clinical and Experimental Medicine, Medical School, University of Reggio Calabria, 88100 Catanzaro, Italy
    J Biol Chem 272:14883-92. 1997
  10. pmc Interleukin-6 trans-signalling differentially regulates proliferation, migration, adhesion and maspin expression in human prostate cancer cells
    Frédéric R Santer
    Department of Urology, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    Endocr Relat Cancer 17:241-53. 2010

Research Grants

  1. Andrew H Miller; Fiscal Year: 2014
  2. Karen H Costenbader; Fiscal Year: 2014
  3. Salah Uddin Ahmed; Fiscal Year: 2016
  4. Howard C Crawford; Fiscal Year: 2015
  5. Proinflammatory Biomarkers and Post-Breast CancerLymphedema
    Mei Rosemary Fu; Fiscal Year: 2012
  6. Can Lifestyle Modify Fatigue in Breast Cancer Survivors?
    Wendy Y Chen; Fiscal Year: 2011
  7. BLAINE ANDREW CHRISTIANSEN; Fiscal Year: 2016
  8. Effect of Diet on Inflammation in Sicke Cell Mice
    Jacqueline M Hibbert; Fiscal Year: 2010
  9. INFLAMMATION, OBESITY AND RISK OF COLORECTAL ADENOMAS
    Robert S Sandler; Fiscal Year: 2010
  10. Sue M Penckofer; Fiscal Year: 2016

Patents

  1. Human interferon beta2A and interferon-beta2B, vectors containing genes coding for said interferons, cell lines producing same and use of said interferons as pharmaceuticals

Detail Information

Publications515 found, 100 shown here

  1. ncbi IL-6 in autoimmune disease and chronic inflammatory proliferative disease
    Katsuhiko Ishihara
    Department of Molecular Oncology C7, Graduate School of Medicine, Osaka University, 2 2 Yamada Oka Suita, Osaka 565 0871, Japan
    Cytokine Growth Factor Rev 13:357-68. 2002
    b>Interleukin 6 (IL-6), which was originally identified as a B-cell differentiation factor, is now known to be a multifunctional cytokine that regulates the immune response, hematopoiesis, the acute phase response, and inflammation...
  2. ncbi Interleukin-6 genetic variability and adiposity: associations in two prospective cohorts and systematic review in 26,944 individuals
    Lu Qi
    Departments of Nutrition and Epidemiology, Harvard School of Public Health, and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 92:3618-25. 2007
    ..IL-6 (IL6) is an immune-modulating cytokine associated with obesity in humans...
  3. doi Genetic polymorphisms in non-alcoholic fatty liver disease: interleukin-6-174G/C polymorphism is associated with non-alcoholic steatohepatitis
    L Carulli
    Dipartimento di Medicina, Endocrinologia, Metabolismo e Geriatria, Nuvo Ospedale Civile S Agostino Estense, Via Giardini 1355, 41100 Modena, Italy
    Dig Liver Dis 41:823-8. 2009
    ..Environmental and genetic factors play a role in the pathogenesis and natural history of non-alcoholic fatty liver disease (NAFLD)...
  4. pmc Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion
    Dimitrios Iliopoulos
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:1397-402. 2011
    ..This dynamic equilibrium provides an additional rationale for combining conventional chemotherapy with metformin, which selectively inhibits CSCs...
  5. pmc Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
    Francis Rodier
    Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
    Nat Cell Biol 11:973-9. 2009
    ..Thus, in addition to orchestrating cell-cycle checkpoints and DNA repair, a new and important role of the DDR is to allow damaged cells to communicate their compromised state to the surrounding tissue...
  6. ncbi Interleukin 6 induces the expression of vascular endothelial growth factor
    T Cohen
    Department of Food Engineering and Biotechnology, Technion, Israel Institute of Technology, Haifa, Israel
    J Biol Chem 271:736-41. 1996
    ..This suggests that secondary structures in the 5'-UTR might be essential for VEGF expression through transcriptional and post-transcriptional control mechanisms...
  7. pmc Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells
    N J Sullivan
    Integrated Biomedical Science Graduate Program, College of Medicine, The Ohio State University, Columbus, OH 43210, USA
    Oncogene 28:2940-7. 2009
    ..To our knowledge, this is the first study that shows IL-6 as an inducer of an EMT phenotype in breast cancer cells and implicates its potential to promote breast cancer metastasis...
  8. ncbi Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin
    T Hirano
    Nature 324:73-6. 1986
    ..The primary sequence of BSF-2 deduced from the cDNA reveals that BSF-2 is a novel interleukin consisting of 184 amino acids...
  9. ncbi HIV-1 Tat induces the expression of the interleukin-6 (IL6) gene by binding to the IL6 leader RNA and by interacting with CAAT enhancer-binding protein beta (NF-IL6) transcription factors
    C Ambrosino
    Department of Clinical and Experimental Medicine, Medical School, University of Reggio Calabria, 88100 Catanzaro, Italy
    J Biol Chem 272:14883-92. 1997
    ..In addition, Tat may function by protein-protein interactions, leading to the generation of heterodimers with specific transcription factors...
  10. pmc Interleukin-6 trans-signalling differentially regulates proliferation, migration, adhesion and maspin expression in human prostate cancer cells
    Frédéric R Santer
    Department of Urology, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    Endocr Relat Cancer 17:241-53. 2010
    ..Collectively, these data suggest that selective targeting of IL-6TS might allow to refine the currently available experimental anti-IL-6 therapies against PC...
  11. doi Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis
    M Bryant Howren
    Department of Psychology, The University of Iowa, 11 Seashore Hall East, Iowa City, IA 52242, USA
    Psychosom Med 71:171-86. 2009
    ..To assess the magnitude and direction of associations of depression with C-reactive protein (CRP), interleukin (IL)-1, and IL-6 in community and clinical samples...
  12. pmc An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation
    Dimitrios Iliopoulos
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Cell 139:693-706. 2009
    ..Thus, inflammation activates a positive feedback loop that maintains the epigenetic transformed state for many generations in the absence of the inducing signal...
  13. pmc IL6 and CRP haplotypes are associated with COPD risk and systemic inflammation: a case-control study
    Dilyara G Yanbaeva
    Department of Respiratory Medicine, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University Medical Centre, Maastricht, The Netherlands
    BMC Med Genet 10:23. 2009
    ..The aim of this study was to examine the association between haplotypes of CRP, IL6 and FGB genes, systemic inflammation, COPD risk and COPD-related phenotypes (respiratory impairment, exercise capacity and body composition)...
  14. pmc Associations of IL6 polymorphisms with lung function decline and COPD
    J Q He
    UBC James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
    Thorax 64:698-704. 2009
    ..There is a functional single nucleotide polymorphism (SNP), -174G/C, in the promoter region of IL6. It was hypothesised that IL6 SNPs influence susceptibility for impaired lung function and COPD in smokers...
  15. ncbi Elevated blood interleukin-6 levels in hyperketonemic type 1 diabetic patients and secretion by acetoacetate-treated cultured U937 monocytes
    Sushil K Jain
    Department of Pediatrics, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
    Diabetes Care 26:2139-43. 2003
    ..This study examined the hypothesis that ketosis increases the circulating levels of IL-6 in type 1 diabetic patients as well as the secretion of IL-6 in vitro in a cell culture model using U937 monocytes...
  16. ncbi Intermittent high glucose enhances ICAM-1, VCAM-1, E-selectin and interleukin-6 expression in human umbilical endothelial cells in culture: the role of poly(ADP-ribose) polymerase
    L Piconi
    Morpurgo Hofman Research Laboratory on Aging, Udine, Italy
    J Thromb Haemost 2:1453-9. 2004
    ..Thus, PARP activation appears to be involved in both promoting nitrosative stress and upregulating adhesion molecules and inflammation in endothelial cells exposed to oscillating high glucose conditions...
  17. pmc STAT1 signaling modulates HIV-1-induced inflammatory responses and leukocyte transmigration across the blood-brain barrier
    Anathbandhu Chaudhuri
    Center for Neurovirology and Neurodegenerative Disorders, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5215, USA
    Blood 111:2062-72. 2008
    ..Inhibition of STAT1 activation could provide a unique therapeutic strategy to attenuate HIV-1-induced BBB compromise and as such improve clinical outcomes...
  18. ncbi Interleukin-6 promotes cervical tumor growth by VEGF-dependent angiogenesis via a STAT3 pathway
    Lin Hung Wei
    Department of Oncology, National Taiwan University Hospital and National Taiwan Unviersity College of Medicine, Taipei 100, Taiwan
    Oncogene 22:1517-27. 2003
    ....
  19. ncbi Impaired glucose tolerance is associated with increased serum concentrations of interleukin 6 and co-regulated acute-phase proteins but not TNF-alpha or its receptors
    S Muller
    German Diabetes Clinic, German Diabetes Research Institute at the University of Düsseldorf, Dusseldorf, Germany
    Diabetologia 45:805-12. 2002
    ..A population-based sample was studied to define immune abnormalities in individuals at risk of Type II (non-insulin-dependent) diabetes mellitus because of impaired glucose tolerance...
  20. ncbi Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130
    T Taga
    Division of Immunology, Osaka University, Japan
    Cell 58:573-81. 1989
    ..These findings indicate that the complex of IL-6 and IL-6-R can interact with a non-ligand-binding membrane glycoprotein, gp130, extracellularly and can provide the IL-6 signal...
  21. pmc IL-6 expression predicts treatment response and outcome in squamous cell carcinoma of the esophagus
    Miao Fen Chen
    Department of Radiation Oncology, Chang Gung Memorial Hospital at Chiayi, Chiayi, Taiwan
    Mol Cancer 12:26. 2013
    ..The identification of potential tumor markers can improve therapeutic planning and patient management. The aim of this study was to highlight the significance of IL-6 in esophageal squamous cell carcinoma (SCC)...
  22. pmc Interleukin-6 is an autocrine growth factor in human prostate cancer
    D Giri
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Pathol 159:2159-65. 2001
    ..These findings strongly support the hypothesis that IL-6 acts as a significant autocrine growth factor in vivo for primary, androgen-dependent prostate cancers...
  23. ncbi Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex
    Martin J Boulanger
    Department of Microbiology and Immunology and Department of Structural Biology, Stanford University School of Medicine, Fairchild D319, 299 Campus Drive, Stanford, CA 94305 5124, USA
    Science 300:2101-4. 2003
    ..The quaternary structures of other IL-6/IL-12 family signaling complexes are likely constructed by means of a similar topological blueprint...
  24. pmc Phosphorylation of Thr-178 and Thr-184 in the TAK1 T-loop is required for interleukin (IL)-1-mediated optimal NFkappaB and AP-1 activation as well as IL-6 gene expression
    Yang Yu
    Texas Children s Cancer Center, Department of Pediatrics, Center for Cardiovascular Development, Department of Medicine, and Michael E DeBakey Department of Surgery, Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030
    J Biol Chem 283:24497-505. 2008
    ..Our finding is the first report that substitution of key serine/threonine residues with acidic residues mimics the phosphorylated state of TAK1 and renders TAK1 active during its induced activation...
  25. ncbi Frequency of distribution of inflammatory cytokines IL-1, IL-6 and TNF-alpha gene polymorphism in patients with obstructive sleep apnea
    K Popko
    Department of Laboratory Medicine and Clinical Immunology of Developmental Age, Warsaw Medical University, Warsaw, Poland
    J Physiol Pharmacol 59:607-14. 2008
    ..The study revealed a significant correlation between polymorphism located in the promoter region of inflammatory cytokine genes and obesity-related OSAS...
  26. pmc Comprehensive analysis of tumor microenvironment cytokines in Waldenstrom macroglobulinemia identifies CCL5 as a novel modulator of IL-6 activity
    Sherine F Elsawa
    Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, MN 55905, USA
    Blood 118:5540-9. 2011
    ..Thus, together these results define a novel signaling network in the WM tumor microenvironment controlling IgM secretion and suggest CCL5 as a potential target for the treatment of this disease...
  27. doi The association between interleukin-6 polymorphisms and rheumatoid arthritis: a meta-analysis
    Young Ho Lee
    Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126 1 Anam dong 5 ga, Seongbuk gu, Seoul 136 705, Korea
    Inflamm Res 61:665-71. 2012
    ..The aim of this study was to determine whether the functional interleukin-6 (IL-6) promoter -174 G/C and -572 G/C polymorphisms confer susceptibility to rheumatoid arthritis (RA) in ethnically different populations...
  28. pmc Interleukin-6 increases prostate cancer cells resistance to bicalutamide via TIF2
    Siting Feng
    Department of Urology and Cancer Center, University of California at Davis Medical Center Research III, Suite 1300, 4645 2nd Avenue, Sacramento, CA 95817, USA
    Mol Cancer Ther 8:665-71. 2009
    ..Our studies suggest that bicalutamide-IL-6-targeted adjunctive therapy may lead to a more effective intervention than bicalutamide alone...
  29. doi Gravity-sensitive signaling drives 3-dimensional formation of multicellular thyroid cancer spheroids
    Jirka Grosse
    Department of Nuclear Medicine, University of Regensburg, Regensburg, Germany
    FASEB J 26:5124-40. 2012
    ..IL-6 protein expression and secretion mirrored its gene expression. Thus, we concluded that the signaling elements IL-6, IL-8, OPN, TLN1, and CTGF are involved with NF-κB p65 in RPM-dependent thyroid carcinoma cell spheroid formation...
  30. ncbi Human immunodeficiency virus type 1 Nef mediates activation of STAT3 in immature dendritic cells
    D Messmer
    North Shore LIJ Research Institute, Manhasset, New York 11030, USA
    AIDS Res Hum Retroviruses 18:1043-50. 2002
    ..This highlights how Nef can signal primary immature DCs, suggesting one way in which Nef may modulate immature DCs to drive virus replication in the DC-T cell milieu...
  31. ncbi Increased interleukin-6 and granulocyte-macrophage colony stimulating factor levels in the sera of patients with non-segmental vitiligo
    Cai Xia Tu
    Department of Dermatology, The First Affiliated Hospital of Dalian Medical University, 222 Zhong shan Lu, Dalian 116011, People s Republic of China
    J Dermatol Sci 31:73-8. 2003
    ..Although the cause of vitiligo is unknown, an autoimmune theory has been proposed, and there is now convincing evidence that cytokines have an important role in pathogenesis of autoimmunity...
  32. pmc Stat3 is tyrosine-phosphorylated through the interleukin-6/glycoprotein 130/Janus kinase pathway in breast cancer
    Marjan Berishaj
    Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021 USA
    Breast Cancer Res 9:R32. 2007
    ..A number of different mechanisms responsible for Stat3 activation, including abnormal activation of receptor tyrosine kinases, Src, and Janus kinases (Jaks), have been implicated in breast cancer...
  33. pmc Simvastatin protects against amyloid beta and HIV-1 Tat-induced promoter activities of inflammatory genes in brain endothelial cells
    Ibolya E Andras
    Molecular Neuroscience and Vascular Biology Laboratory, Department of Neurosurgery, University of Kentucky Medical Center, 593 Wethington Bldg, 900 S Limestone, Lexington, KY 40536, USA
    Mol Pharmacol 73:1424-33. 2008
    ..In addition, simvastatin may provide a beneficial influence by reducing these effects at the BBB level...
  34. pmc Differential cytokine regulation by NF-kappaB and AP-1 in Jurkat T-cells
    Hazem Khalaf
    Biology, Orebro Life Science Center, School of Science and Technology, Orebro University, SE 701 82 Orebro, Sweden
    BMC Immunol 11:26. 2010
    ..The aim of this study was to investigate the role of the transcription factors, AP-1 and NF-kappaB, in IL-6 and CXCL8 regulation in Jurkat T-cells...
  35. ncbi The recurrence of leprosy reactional episodes could be associated with oral chronic infections and expression of serum IL-1, TNF-alpha, IL-6, IFN-gamma and IL-10
    Ana Carolina F Motta
    Division of Dermatology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    Braz Dent J 21:158-64. 2010
    ..05). These results suggest that oral infection could be involved as a maintenance factor in the pathogenesis of leprosy reactional episodes...
  36. doi The interleukin-6 gene -572C/G promoter polymorphism modifies Alzheimer's risk in APOE epsilon 4 carriers
    Min Wang
    Department of Neurology, Xuan Wu Hospital of the Capital Medical University, Beijing, PR China
    Neurosci Lett 482:260-3. 2010
    ..301-fold (Wald=11.093, adjust OR=3.301, 95% CI=1.635-6.665, P=0.001) compared to CG+GG genotype. The present results suggest the -572 polymorphism could modify the risk for SAD in APOE epsilon 4 carriers...
  37. doi Human nucleus pulposus cells react to IL-6: independent actions and amplification of response to IL-1 and TNF-α
    Rebecca K Studer
    VA Pittsburgh, Pittsburgh, PA, USA
    Spine (Phila Pa 1976) 36:593-9. 2011
    ..CONCLUSION.: The results suggest maneuvers to diminish IL-6 production in the disc could provide some protection against the adverse effects of IL-1 and TNF-α, thus, helping preserve disc composition, structure, and function...
  38. doi Regulation of the p38 mitogen-activated protein kinase and dual-specificity phosphatase 1 feedback loop modulates the induction of interleukin 6 and 8 in cells infected with coronavirus infectious bronchitis virus
    Ying Liao
    School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore
    Virology 420:106-16. 2011
    ....
  39. doi Hck tyrosine kinase regulates TLR4-induced TNF and IL-6 production via AP-1
    Maria J Smolinska
    Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Kennedy Institute of Rheumatology, Oxford University, London W6 8LH, United Kingdom
    J Immunol 187:6043-51. 2011
    ..These data highlight the importance of Hck as an active component in LPS-induced TLR signaling and suggest the possibility of targeting this kinase for the alleviation of excessive inflammation...
  40. ncbi A -174G/C polymorphism of the interleukin-6 gene in patients with lacunar infarction
    Marian Revilla
    Service of Neurology, Hospital Clinic Universitari, Villarroel 170, 08036 Barcelona, Spain
    Neurosci Lett 324:29-32. 2002
    ..28; 95% CI, 1.22-15.00). These findings suggest that lacunar stroke might result from genetic susceptibility to inflammation-mediated damage in concert with atherosclerotic risk factors...
  41. doi The additive contribution from inflammatory genetic markers on the severity of cardiovascular disease
    K K Berg
    Department of Laboratory Medicine, Children s and Women s Health, The Norwegian University of Science and Technology, Trondheim, Norway
    Scand J Immunol 69:36-42. 2009
    ..Furthermore, the additive contribution from different inflammatory genetic markers strongly enhances the individual severity of cardiovascular disease...
  42. ncbi Body composition and -174G/C interleukin-6 promoter gene polymorphism: association with progression of insulin resistance in normal weight obese syndrome
    L di Renzo
    Department of Neuroscience, Division of Human Nutrition University of Tor Vergata, Via Montpellier 1, I 00133 Rome, Italy
    Curr Pharm Des 14:2699-706. 2008
    ..174 G/C IL-6 promoter polymorphism represents a marker which could help to identify, time in advance, "vulnerable" individuals at risk of age and obesity related diseases...
  43. ncbi A gender--dependent genetic predisposition to produce high levels of IL-6 is detrimental for longevity
    M BonaFe
    Department of Experimental Pathology, Bologna University, Bologna, Italy
    Eur J Immunol 31:2357-61. 2001
    ..On the whole, our data suggest that those individuals who are genetically predisposed to produce high levels of IL-6 during aging, i.e. -174 locus GG homozygous men, are disadvantaged for longevity...
  44. ncbi Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects
    Victoria Rotter
    Department of Internal Medicine, Lundberg Laboratory for Diabetes Research, The Sahlgrenska Academy, Goteborg University, SE 413 45 Goteborg, Sweden
    J Biol Chem 278:45777-84. 2003
    ..We conclude that IL-6 can play an important role in insulin resistance in man and, furthermore, that it may act in concert with other cytokines that also are up-regulated in adipose cells in insulin resistance...
  45. pmc Computational identification of gene-social environment interaction at the human IL6 locus
    Steven W Cole
    Department of Medicine and Norman Cousins Center, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 107:5681-6. 2010
    ....
  46. doi IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer
    Markus F Neurath
    1st Medical Clinic, University of Erlangen Nurnberg, Germany
    Cytokine Growth Factor Rev 22:83-9. 2011
    ..In this review article, we discuss the latest findings on the role of IL-6 in experimental models of autoimmunity and cancer, as well as clinical perspectives...
  47. ncbi Endurance training reduces the contraction-induced interleukin-6 mRNA expression in human skeletal muscle
    Christian P Fischer
    Dept of Infectious Diseases, Rigshospitalet, Blegdamsvej 9, Section M7641, DK 2100 Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 287:E1189-94. 2004
    ..In conclusion, the magnitude of the exercise-induced IL-6 mRNA expression in contracting human skeletal muscle was markedly reduced by 10 wk of training...
  48. ncbi Acute IL-6 treatment increases fatty acid turnover in elderly humans in vivo and in tissue culture in vitro
    E W Petersen
    Copenhagen Muscle Research Center, Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 288:E155-62. 2005
    ..Moreover, IL-6 appears to be activating lipolysis independently of elevations in GH and/or cortisol and appears to be a potent catalyst for fat oxidation in muscle cells...
  49. ncbi Polymorphisms of genes involved in innate immunity: association with preterm delivery
    Ch Härtel
    Department of Pediatrics, University of Luebeck, Germany
    Mol Hum Reprod 10:911-5. 2004
    ....
  50. ncbi Alpha-synuclein and its disease-causing mutants induce ICAM-1 and IL-6 in human astrocytes and astrocytoma cells
    Andis Klegeris
    Kinsmen Laboratory of Neurological Research, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada
    FASEB J 20:2000-8. 2006
    ..5 microM respectively. We hypothesize that the neuroinflammation stimulated by release of an excess of normal alpha-synuclein or by release of its mutated forms can be involved in the pathobiology of PD...
  51. pmc Intracellular Tat of human immunodeficiency virus type 1 activates lytic cycle replication of Kaposi's sarcoma-associated herpesvirus: role of JAK/STAT signaling
    Yi Zeng
    Department of Microbiology and Immunology, Nanjing Medical University, Nanjing 210029, People s Republic of China
    J Virol 81:2401-17. 2007
    ..These findings suggest that Tat may participate in KS pathogenesis by inducing KSHV replication and increasing KSHV viral load. These data also suggest that JAK/STAT signaling may be of therapeutic value in AIDS-related KS patients...
  52. doi Serum interleukin-6 levels in colorectal cancer patients--a summary of published results
    Heike Knüpfer
    Institute of Clinical Pharmacology, University of Leipzig, Härtelstrasse 16 18, 04107 Leipzig, Germany
    Int J Colorectal Dis 25:135-40. 2010
    ..The study's aim was to assess the potential of circulating IL-6 as a prognostic indicator in colorectal cancer...
  53. pmc Palmitate induced IL-6 and MCP-1 expression in human bladder smooth muscle cells provides a link between diabetes and urinary tract infections
    Andreas Oberbach
    Department of Medicine, University of Leipzig, Leipzig, Germany
    PLoS ONE 5:e10882. 2010
    ....
  54. ncbi Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes
    Joseph J Senn
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, New York 14642, USA
    J Biol Chem 278:13740-6. 2003
    ..These data suggest that induction of SOCS-3 in liver may be an important mechanism of IL-6-mediated insulin resistance...
  55. pmc Prostaglandin E2 induces interleukin-6 expression in human chondrocytes via cAMP/protein kinase A- and phosphatidylinositol 3-kinase-dependent NF-kappaB activation
    Pu Wang
    Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA
    Am J Physiol Cell Physiol 298:C1445-56. 2010
    ..Cumulatively, our data show that PGE(2) and forskolin induce IL-6 expression in human chondrocytes via cAMP/PKA and PI3K-dependent pathways, which in turn regulate the activation and binding of p65 to the IL-6 promoter...
  56. pmc IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland
    Pasquale Sansone
    Center for Applied Biomedical Research, St Orsola Malpighi University Hospital, Department of Pharmacology and Toxicology, University of Bologna, Bologna, Italy
    J Clin Invest 117:3988-4002. 2007
    ..In conclusion, these data support the hypothesis that IL-6 induces malignant features in Notch-3-expressing stem/progenitor cells from human ductal breast carcinoma and normal mammary gland...
  57. doi Mechanisms and pathologic significances in increase in serum interleukin-6 (IL-6) and soluble IL-6 receptor after administration of an anti-IL-6 receptor antibody, tocilizumab, in patients with rheumatoid arthritis and Castleman disease
    Norihiro Nishimoto
    Laboratory of Immune Regulation, Graduate School of Frontier Bioscience, Osaka University, Osaka, Japan
    Blood 112:3959-64. 2008
    ..We also concluded that the increased level of free IL-6 during tocilizumab treatment closely reflects the actual endogenous IL-6 production and true disease activity...
  58. doi High serum interleukin-6 level predicts future hepatocellular carcinoma development in patients with chronic hepatitis B
    Vincent Wai Sun Wong
    Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong
    Int J Cancer 124:2766-70. 2009
    ..This may assist clinicians in selecting high-risk patients for HCC surveillance program...
  59. doi Interleukin-6 and type I interferon-regulated genes and chemokines mark disease activity in dermatomyositis
    Hatice Bilgic
    University of Minnesota, Minneapolis, MN 55455, USA
    Arthritis Rheum 60:3436-46. 2009
    ..This study was performed to evaluate the capacity of IFN-dependent peripheral blood gene and chemokine signatures and levels of proinflammatory cytokines to serve as biomarkers for disease activity in adult and juvenile DM...
  60. doi Serum interleukin-6 level but not genotype predicts survival after resection in stages II and III gastric carcinoma
    Wei Chih Liao
    Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan
    Clin Cancer Res 14:428-34. 2008
    ..The objective of this study was to evaluate the association between serum IL-6 levels, -634G/C polymorphism, and overall survival after resection for gastric carcinoma...
  61. ncbi Interleukin-6 gene -174g>c and -572g>c promoter polymorphisms are strong predictors of plasma interleukin-6 levels after coronary artery bypass surgery
    D J Brull
    Division of Cardiovascular Genetics, Department of Medicine, Royal Free and University College London Medical School, London, UK
    Arterioscler Thromb Vasc Biol 21:1458-63. 2001
    ....
  62. ncbi Cytokine promoter polymorphisms in Taiwanese patients with Graves' disease
    Ming Yuh Shiau
    Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, Republic of China
    Clin Biochem 40:213-7. 2007
    ....
  63. doi Fatty acids, IL6, and TNFalpha polymorphisms: an example of nutrigenetics in Crohn's disease
    Catarina Sousa Guerreiro
    Department of Dietetics, Escola Superior de Tecnologia da Saúde de Lisboa, Unidade de Nutrição e Metabolismo do Instituto de Medicina Molecular da Universidade de Lisboa, 1990 096 Lisboa, Portugal
    Am J Gastroenterol 104:2241-9. 2009
    ....
  64. doi TGFβ1 induces IL-6 and inhibits IL-8 release in human bronchial epithelial cells: the role of Smad2/3
    Qi Ge
    Respiratory Research Group, Discipline of Pharmacology, Faculty of Medicine, The University of Sydney, Sydney, NSW, Australia
    J Cell Physiol 225:846-54. 2010
    ..Understanding the mechanism of aberrant pro-inflammatory cytokine production in asthmatic airways will allow the development of alternative ways to control airway inflammation...
  65. doi Variants at the promoter of the interleukin-6 gene are associated with severity and outcome of pneumococcal community-acquired pneumonia
    Ignacio Martin-Loeches
    Critical Care Centre, Corporació Sanitaria Parc Tauli University Hospital Sabadell, Sabadell, Spain
    Intensive Care Med 38:256-62. 2012
    ..We studied the genetic variability at IL6 in patients with community-acquired pneumonia (CAP) and pneumococcal CAP (P-CAP)...
  66. pmc A two-SNP IL-6 promoter haplotype is associated with increased lung cancer risk
    Jun Chen
    Department of Surgery, The First Affiliated Hospital, Soochow University, 188 Shizi Street, Suzhou 215006, People s Republic of China
    J Cancer Res Clin Oncol 139:231-42. 2013
    ..We tested the hypothesis that single-nucleotide polymorphism (SNP) and/or haplotypes of IL-6 promoter are associated with risk of lung cancer...
  67. pmc Induction of neuronal differentiation in PC12 cells by B-cell stimulatory factor 2/interleukin 6
    T Satoh
    Institute of Medical Science, University of Tokyo, Japan
    Mol Cell Biol 8:3546-9. 1988
    ..The BSF-2-stimulated PC12 cells expressed the c-fos proto-oncogene transiently, and they began to change morphologically to neurite-extending cells after several days. The number of voltage-dependent Na+ channels was also increased...
  68. pmc 1.9 A crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling
    W Somers
    Small Molecule Drug Discovery, Genetics Institute, Inc, Cambridge, MA 02140, USA
    EMBO J 16:989-97. 1997
    b>Interleukin 6 (IL-6) has many biological activities in vivo, and deregulation has been implicated in many disease processes. IL-6, a 185 amino acid polypeptide was refolded, purified and crystallized. The crystals diffracted to beyond 1...
  69. ncbi The interleukin-6 -174 G/C promoter polymorphism is associated with risk of coronary heart disease and systolic blood pressure in healthy men
    S E Humphries
    Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Department of Medicine, Royal Free and University College London Medical School, London, UK
    Eur Heart J 22:2243-52. 2001
    ..K. men...
  70. ncbi Genetic variants of TNF-[FC12]a, IL-1beta, IL-4 receptor [FC12]a-chain, IL-6 and IL-10 genes are not risk factors for sepsis in low-birth-weight infants
    Andras Treszl
    Research Laboratory of Pediatrics and Nephrology, Semmelweis University, Budapest, Hungary
    Biol Neonate 83:241-5. 2003
    ..We concluded that these genetic polymorphisms do not influence the risk and course of sepsis in VLBW neonates...
  71. ncbi Association of polymorphisms of interleukin-6, osteocalcin, and vitamin D receptor genes, alone or in combination, with bone mineral density in community-dwelling Japanese women and men
    Yoshiji Yamada
    Department of Gene Therapy, Gifu International Institute of Biotechnology and Institute of Applied Biochemistry, Mitake, Gifu 505 0116, Japan
    J Clin Endocrinol Metab 88:3372-8. 2003
    ..The combined IL-6 and osteocalcin genotypes may prove informative for the assessment of osteoporosis in women...
  72. ncbi C-reactive protein and interleukin-6 in vascular disease: culprits or passive bystanders?
    Marcello Rattazzi
    Dipartimento di Medicina Clinica e Sperimentale, Universita di Padova, Italy
    J Hypertens 21:1787-803. 2003
    ..In this paper we will review the evidence concerning the cardiovascular prognostic value and the potential direct involvement of CRP and IL-6 in atherogenesis...
  73. pmc Relationship between heart rate variability, interleukin-6, and soluble tissue factor in healthy subjects
    Roland von Kanel
    Department of General Internal Medicine, University Hospital Berne, Switzerland
    Brain Behav Immun 22:461-8. 2008
    ..Inflammation and related hypercoagulability might particularly contribute to atherothrombotic events in a setting of decreased HRV...
  74. doi Cytokine gene polymorphisms in periodontal disease: a meta-analysis of 53 studies including 4178 cases and 4590 controls
    Georgios K Nikolopoulos
    Hellenic Centre for Diseases Control and Prevention, Athens, Greece
    J Clin Periodontol 35:754-67. 2008
    ..We conducted a systematic review and a meta-analysis, in order to investigate the potential association of cytokine gene polymorphisms with either aggressive or chronic periodontal disease...
  75. doi Polymorphism in the IL6 promoter region is associated with the risk factors and markers of subclinical atherosclerosis in men: The Cardiovascular Risk in Young Finns Study
    Janne Hulkkonen
    Department of Clinical Physiology, Tampere University Hospital, Finland
    Atherosclerosis 203:454-8. 2009
    ..We investigated whether IL6 -174 G>C associates with the risk factors of atherosclerosis and carotid artery compliance (CAC) in young subjects...
  76. ncbi Variants in the coagulation factor 2 receptor (F2R) gene influence the risk of myocardial infarction in men through an interaction with interleukin 6 serum levels
    Bruna Gigante
    Division of Cardiovascular Epidemiology, IMM, Karolinska Institute, 17 177 Stockholm, Sweden
    Thromb Haemost 101:943-53. 2009
    ..03). Our results demonstrate that in men F2R genetic variants influence the risk of MI mainly through an interaction with IL6 serum levels...
  77. doi Interleukin-6 genotype and risk for cerebral palsy in term and near-term infants
    Yvonne W Wu
    Department of Neurology, University of California, San Francisco, San Francisco, CA 94143 0137, USA
    Ann Neurol 66:663-70. 2009
    ..A functional polymorphism in the interleukin-6 (IL-6) gene has been implicated in newborn brain injury. We studied whether the IL-6 -174 G/C polymorphism confers increased risk for CP in term infants...
  78. pmc Combining C-reactive protein and interleukin-6 may be useful to detect periprosthetic hip infection
    Martin A Buttaro
    Hip Surgery Unit, Institute of Orthopaedics Carlos E Ottolenghi, Italian Hospital of Buenos Aires, Potosi 4215 C1199ACK, Buenos Aires, Argentina
    Clin Orthop Relat Res 468:3263-7. 2010
    ..The sensitivity and specificity to detect periprosthetic infection of the different methods have been questioned, and no single laboratory test accurately detects infection before revision arthroplasty...
  79. pmc Common variations in the genes encoding C-reactive protein, tumor necrosis factor-alpha, and interleukin-6, and the risk of clinical diabetes in the Women's Health Initiative Observational Study
    Kei Hang K Chan
    Program on Genomics and Nutrition, Department of Epidemiology, UCLA, Los Angeles, CA 90095, USA
    Clin Chem 57:317-25. 2011
    ..Circulating concentrations of high-sensitivity C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) have been associated with an increased risk of diabetes...
  80. doi Secretion of IL-6 and IL-8 from lysophosphatidic acid-stimulated oral squamous cell carcinoma promotes osteoclastogenesis and bone resorption
    Young Sun Hwang
    Oral Cancer Research Institute, Yonsei University College of Dentistry, Republic of Korea
    Oral Oncol 48:40-8. 2012
    ..LPA-induced IL-6 and IL-8 exerted propound effects on RANKL expression in osteoblast and thereby promoted osteoclast formation from osteoclast precursors...
  81. doi Interleukin-6 promoter polymorphism and plasma levels in patients with schizophrenia
    R Zakharyan
    Laboratory of Macromolecular Complexes, Institute of Molecular Biology, National Academy of Sciences of Republic of Armenia, Yerevan, Armenia
    Tissue Antigens 80:136-42. 2012
    ..We also conclude that IL6 rs1800795*C allele is linked to increased IL-6 blood levels and may be a risk factor for schizophrenia development at least in Armenian population...
  82. doi The Th1/Th2/Th17 cytokine profile of HIV-infected individuals: a multivariate cytokinomics approach
    Aurelia Williams
    Department of Biochemistry, University of Pretoria, Pretoria 0002, South Africa
    Cytokine 61:521-6. 2013
    ..This possibility was supported by other clinical indicators. Taken together, the measured cytokines (IL-6, 10 and 17) have potential prognostic value...
  83. doi Lack of an association between interleukin-6 -174G/C polymorphism and circulating interleukin-6 levels in normal population: a meta-analysis
    Mingyuan Huang
    Department of Cardiology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
    DNA Cell Biol 32:654-64. 2013
    ..05, 95%CI: -0.11-0.01). The meta-analysis provides evidence that the -174G/C polymorphism in the IL-6 gene is not significantly associated with circulating IL-6 levels in a normal population. ..
  84. doi Coexpression of aPKCλ/ι and IL-6 in prostate cancer tissue correlates with biochemical recurrence
    Hitoshi Ishiguro
    Department of Urology, Yokohama City University Graduate School of Medicine, Kanagawa, Japan
    Cancer Sci 102:1576-81. 2011
    ..03 in the multivariate analysis). These results indicate a strong correlation between aPKCλ/ι and IL-6 in prostate tumors, and that the aPKCλ/ι-IL-6 axis is a reliable prognostic factor for the biochemical recurrence of this cancer...
  85. ncbi Interleukin-6 and diabetes: the good, the bad, or the indifferent?
    Ole P Kristiansen
    Steno Diabetes Center, 2 Niels Steensens Vej, DK 2820 Gentofte, Denmark
    Diabetes 54:S114-24. 2005
    ..Thus, the two types of diabetes are also in this respect less apart than apparent. However, the mechanisms are not clear, and we therefore propose future directions for studies in this field...
  86. doi High adiponectin and adiponectin receptor 1 expression in synovial fluids and synovial tissues of patients with rheumatoid arthritis
    Wenfeng Tan
    Department of Rheumatology, Clinical Experiment Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
    Semin Arthritis Rheum 38:420-7. 2009
    ..Osteoarthritis patients and healthy subjects served as controls...
  87. doi Identification of a novel regulatory region in the interleukin-6 gene promoter
    J M Samuel
    Department of Immunology and Molecular Pathology, University College London, 46, Cleveland Street, London W1T4 JF, UK
    Cytokine 42:256-64. 2008
    ....
  88. doi Regulation of endothelin-1-induced interleukin-6 production by Ca2+ influx in human airway smooth muscle cells
    Susumu Iwata
    Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Eur J Pharmacol 605:15-22. 2009
    ..These findings demonstrate that endothelin-1-induced IL-6 synthesis in airway smooth muscle cells occurs via two parallel but independent events that include Ca(2+) influx and activation of ERK1/2 and p38...
  89. pmc aPKClambda/iota promotes growth of prostate cancer cells in an autocrine manner through transcriptional activation of interleukin-6
    Hitoshi Ishiguro
    Department of Urology, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, Kanagawa 236 0004, Japan
    Proc Natl Acad Sci U S A 106:16369-74. 2009
    ..Further, aPKClambda/iota expression might be a biomarker for prostate cancer progression...
  90. doi Interleukin-1 beta and interleukin-6 gene polymorphism associations with angiographically assessed coronary artery disease in Brazilians
    Domingos L S Rios
    Departamento de Ciências da Vida, Universidade do Estado da Bahia UNEB, Campus I, Rua SilveiraMartins, n 2555, ZIP code 41 195 001, Salvador, BA, Brazil
    Cytokine 50:292-6. 2010
    ..This report shows that the IL-1B-511C>T and IL-6-174G>C polymorphisms were associated with CAD risk in African-Brazilians and no association was detected among Caucasian-Brazilians...
  91. doi IL-6 polymorphism associated with fatal outcome in patients with severe traumatic brain injury
    André Luiz Dalla Libera
    Programa de Pós Graduação em Genética e Toxicologia Aplicada, Universidade Luterana do Brasil ULBRA, Canoas, Brazil
    Brain Inj 25:365-9. 2011
    ....
  92. pmc HIV-1 gp120 induces expression of IL-6 through a nuclear factor-kappa B-dependent mechanism: suppression by gp120 specific small interfering RNA
    Ankit Shah
    Division of Pharmacology, School of Pharmacy, University of Missouri Kansas City, Kansas City, Missouri, United States of America
    PLoS ONE 6:e21261. 2011
    ..These results demonstrate that HIV-1 gp120-mediated over-expression of IL-6 in astrocytes is one mechanism responsible for neuroinflammation in HIV-infected individuals and this is mediated by the NF-κB pathway...
  93. doi Increased IL-6 levels are not related to NF-κB or HIF-1α transcription factors activity in the vitreous of proliferative diabetic retinopathy
    Olli Arjamaa
    Department of Biology, University of Turku, Finland
    J Diabetes Complications 25:393-7. 2011
    ....
  94. pmc HIV-1 Nef induces proinflammatory state in macrophages through its acidic cluster domain: involvement of TNF alpha receptor associated factor 2
    Giorgio Mangino
    Department of Biology, University Roma Tre, Rome, Italy
    PLoS ONE 6:e22982. 2011
    ....
  95. doi Interleukin-6 autocrine signaling mediates melatonin MT(1/2) receptor-induced STAT3 Tyr(705) phosphorylation
    Winnie W I Lau
    Division of Life Science and the Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
    J Pineal Res 52:477-89. 2012
    ..Our results demonstrate that melatonin receptor/Gα(16) coupling is capable of triggering the production of cytokines including IL-6, and this autocrine loop may account for the subsequent STAT3 phosphorylation at Tyr(705) ...
  96. doi A humanized anti-IL-6 antibody (ALD518) in non-small cell lung cancer
    Trevor J Bayliss
    Dartmouth Hitchcock Medical Center, Comprehensive Thoracic Oncology Program, Norris Cotton Cancer Center, Lebanon, USA
    Expert Opin Biol Ther 11:1663-8. 2011
    ..IL-6 has been implicated in resistance of lung cancer to EGF inhibitors. A mAb therapy targeting IL-6 may be an effective treatment for the inflammatory microenvironment in lung cancer...
  97. ncbi Study of the role of interleukin-6 and highly sensitive C-reactive protein in diabetic nephropathy in type 1 diabetic patients
    S Shelbaya
    Department of Internal Medicine, Endocrine Unit, School of Medicine, Ain Shams University, Cairo, Egypt
    Eur Rev Med Pharmacol Sci 16:176-82. 2012
    ..The pathogenesis of diabetic nephropathy is still a matter of debate. There are conflicting results regarding the relation of C reactive protein (CRP), interleukin-6 (IL-6) and diabetic nephropathy in type 1 diabetes...
  98. ncbi IL6 gene promoter polymorphisms and type 2 diabetes: joint analysis of individual participants' data from 21 studies
    Cornelia Huth
    GSF Institute of Epidemiology, Neuherberg, Germany
    Diabetes 55:2915-21. 2006
    ....
  99. pmc Interleukin (IL) 1beta induction of IL-6 is mediated by a novel phosphatidylinositol 3-kinase-dependent AKT/IkappaB kinase alpha pathway targeting activator protein-1
    Catherine M Cahill
    Neurochemistry Laboratory, Department of Psychiatry Neuroscience and Genetics and Aging Research Unit, Massachusetts General Hospital East, Charlestown, Massachusetts 02129, USA
    J Biol Chem 283:25900-12. 2008
    ..This novel pathway is a parallel pathway to the PI 3-kinase/AKT upstream of NFkappaB and both are involved in IL-6 gene transcription in response to IL-1...
  100. doi Higher IL-6 levels but not IL6 -174G>C or -572G>C genotype are associated with post-operative complication following coronary artery bypass graft (CABG) surgery
    Julie Sanders
    Department of Surgery, University College London, London, UK
    Atherosclerosis 204:196-201. 2009
    ..Thus, in conclusion, elevated pre-operative IL-6 levels, but not IL6 gene variants predict poor patient outcome following CABG...
  101. pmc Association of interleukin-6 signalling with the muscle stem cell response following muscle-lengthening contractions in humans
    Bryon R McKay
    Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 4:e6027. 2009
    ....

Research Grants87

  1. Andrew H Miller; Fiscal Year: 2014
    ..abstract_text> ..
  2. Karen H Costenbader; Fiscal Year: 2014
    ....
  3. Salah Uddin Ahmed; Fiscal Year: 2016
    ..Successful completion of this study will lay the foundation for testing EGCG as a treatment option for RA and other inflammatory diseases. ..
  4. Howard C Crawford; Fiscal Year: 2015
    ..3, we will use pharmacological inhibition of ADAM17 released cytokines tumor necrosis factor alpha (TNFa) and interleukin 6 receptor (IL6R) to test for their influence on the etiology of pancreatic inflammation and PDA in vivo...
  5. Proinflammatory Biomarkers and Post-Breast CancerLymphedema
    Mei Rosemary Fu; Fiscal Year: 2012
    ..Findings of the project are fundamental in developing and testing more intense and personalized interventions to prevent and treat LE among the breast cancer survivors. ..
  6. Can Lifestyle Modify Fatigue in Breast Cancer Survivors?
    Wendy Y Chen; Fiscal Year: 2011
    ....
  7. BLAINE ANDREW CHRISTIANSEN; Fiscal Year: 2016
    ..During the mentored period I will successfully transition from the mentored stage of my career to an independent investigator. ..
  8. Effect of Diet on Inflammation in Sicke Cell Mice
    Jacqueline M Hibbert; Fiscal Year: 2010
    ..The use of this mouse model is important for investigating the time course of sickle cell induced tissue inflammation, and for seeking practical and effective dietary treatment to reduce the tissue injury. ..
  9. INFLAMMATION, OBESITY AND RISK OF COLORECTAL ADENOMAS
    Robert S Sandler; Fiscal Year: 2010
    ..Ultimately the results may inform surveillance and prevention strategies. ..
  10. Sue M Penckofer; Fiscal Year: 2016
    ..Thus, the potential for using this therapy is highly significant fr women with type 2 diabetes and other chronic populations who suffer from symptoms of depression which significantly impacts the self-management of their health. ..
  11. LAUREN BERSH ALLOY; Fiscal Year: 2016
    ..It may lead to novel interventions for depression that target cognitive influences on cytokine responses to stress, as well as pharmacological manipulations of cytokines to address symptoms such as fatigue, anhedonia, and withdrawal. ..
  12. Central Mechanisms of Orofacial Pain
    Jianren Mao; Fiscal Year: 2012
    ..The outcome of this study could lead to the development of new therapeutic tools to treat often intractable and debilitating clinical orofacial pain. ..
  13. Characterizing Inflammation And Downstream Effects During Chronic Viral Infection
    Elina I Zuniga; Fiscal Year: 2012
    ..We found that interleukin 6 (IL-6) is produced in a unique biphasic manner during persistent LCMV infection, with late IL-6 being ..
  14. RANDLE MICHAEL GALLUCCI; Fiscal Year: 2016
    ..The proinflammatory cytokine interleukin 6 (IL-6) is closely associated with skin healing and barrier maintenance...
  15. Inflammation and Sub-Clinical Renal Damage in Cocaine-Dependent African Americans
    ELIZABETH GROOMS NESMITH; Fiscal Year: 2010
    ....
  16. Lead, Cadmium,Arsenic, and cardiovascular risk in children
    Eliseo Guallar; Fiscal Year: 2011
    ..The information obtained in this study will be relevant to millions of children in the US and abroad who are chronically exposed to lead, cadmium, and arsenic in the environment. ..
  17. Elena Barengolts; Fiscal Year: 2014
    ....
  18. Cranial Stimulation for Chemotherapy Symptoms in Breast Cancer
    Deborah B McGuire; Fiscal Year: 2013
    ..Results from this study may also help to identify more clearly the biological causes for common, distressing symptoms. ..
  19. Debra E Lyon; Fiscal Year: 2014
    ..levels of C- reactive protein (CRP), tumor necrosis factor alpha (TNF-a), interleukin 1 beta (IL-1B), and interleukin 6 (IL- 6)], and epigenetic alterations in 75 women diagnosed with early-stage BC across 5 timepoints: prior to ..
  20. Inflammatory Biomarkers and Colorectal Cancer Risk
    Gong Yang; Fiscal Year: 2010
    ..Overall, this study will contribute significantly to the understanding of the role of inflammation in the etiology of CRC and to the development of new strategies for the assessment of CRC risk. ..
  21. Brian C Jacobson; Fiscal Year: 2014
    ..between diet;gender;circulating levels of insulin, insulin derived growth factor, leptin, adiponectin, interleukin 6, tumor necrosis factor alpha, c-reactive protein, and other markers of insulin resistance and systemic ..
  22. Risk Factors for Incident Alzheimer's Disease in a Biracial Community
    Denis A Evans; Fiscal Year: 2010
    ....
  23. Dietary Inflammatory Index and Risk of Cancer in Women
    FRED KINYUY TABUNG; Fiscal Year: 2013
    ....
  24. Jonathan Savitz; Fiscal Year: 2016
    ..One of the pro-inflammatory cytokines that drives this metabolic shunt towards KYN synthesis is interleukin 6 (IL6), an effect that is partly countered by the anti-inflammatory cytokine, interleuin 10 (IL10)...
  25. Anisa Shaker; Fiscal Year: 2016
    ..These studies may provide the basis for novel therapeutic approaches to inflammatory bowel disease and CAC. ..
  26. Cong Yan; Fiscal Year: 2014
    ..One commonly induced pro-inflammatory gene group during pulmonary inflammation is the interleukin 6 (IL-6) family cytokines...
  27. Zhongcong Xie; Fiscal Year: 2016
    ..This proposal aims to investigate an understudied topic in an innovative system by testing novel hypotheses. Our efforts would ultimately lead to safer surgical care and better post-operative outcomes for senior patients. ..
  28. Interactions Between Depression, Neuroinflammation and Glycogen Synthase Kinase-3
    Eleonore Beurel; Fiscal Year: 2011
    ..The goals are to clarify potential causative mechanisms and discern how these are altered by therapeutic interventions with the aim of developing better therapeutic interventions for mood disorders. ..
  29. Persistent microRNA changes in serum of cancer-free breast cancer patients
    Harikrishna Nakshatri; Fiscal Year: 2012
    ..Cancer or host-response to cancer causes elevated levels of circulating cytokines such as interleukin 6 (IL-6), which may mediate the long-term effects of cancer on microRNA expression in distant organs...
  30. Eleonore Beurel; Fiscal Year: 2014
    ..Specific Aim 3 will test the hypothesis that GSK3 promotes depression-like behavioral responses to inflammatory and environmental stress. ..
  31. RNA-Seq studies of Gene Expression in Cells and Networks in FI and ACC in Autism
    Barbara J Wold; Fiscal Year: 2010
    ..We found that VENs express receptors for the cytokines interleukin 4 (IL4R) and interleukin 6 (IL6R) in normal and autistic subjects, and RNA-Seq identified a prominent gene network related to ..
  32. Vitamin D and the Immune System
    Lawrence Steinman; Fiscal Year: 2012
    ....
  33. Dan M Cooper; Fiscal Year: 2016
    ..Should the positive effects of augmented exercise on body composition be supported, we would then anticipate widespread benefit in preventing long-term health consequences of prematurity at relatively low cost. ..
  34. Robert J Cousins; Fiscal Year: 2016
    ..These may benefit from zinc supplementation or drugs designed to influence ZIP14 activity. ..
  35. DC-T Cell Interactions in Pulmonary Immune Responses
    Anuradha Ray; Fiscal Year: 2012
    ..These studies will help identify targets for inhibiting undesired immune responses in the lung at the same time promoting those that protect from infectious agents. ..
  36. Sharon S Evans; Fiscal Year: 2014
    ..These studies further have the potential to lead to novel therapeutic targets for the promotion of immune surveillance as well as for the treatment of chronic inflammation. ..
  37. Peter M Abadir; Fiscal Year: 2014
    ..Q-PCR and western blot will be used to quantify the change in expression of AT1R and AT2R in response to IL-6 treatment. ..
  38. Tomoki Hashimoto; Fiscal Year: 2016
    ..This study will be a basis for future studies to test pharmacological therapies that target mast cells or mast cells-derived cytokines for the prevention of aneurysmal subarachnoid hemorrhage. ..
  39. ANDREA G NACKLEY NEELY; Fiscal Year: 2014
    ..g., beta2- and beta3ARs) for development of effective therapies for patients with persistent pain conditions.]] ..
  40. GINGIVA DERIVED MSCS: ROLE IN IMMUNOMODULATION AND TISSUE REGENERATION
    Yufang Shi; Fiscal Year: 2013
    ..abstract_text> ..
  41. STAT3 Structural Determinants
    Nancy C Reich; Fiscal Year: 2012
    ..Achievement of the aims is expected to contribute to an understanding of the function of the STAT3 transcription factor, and to contribute to the development of clinically useful inhibitors. ..
  42. Francis E Lotrich; Fiscal Year: 2014
    ..This may be a common pathway for genes, stress, and inflammation to influence risk for depression. ..
  43. Inflammatory Control of Lymphocyte Trafficking
    Sharon Evans; Fiscal Year: 2009
    ..abstract_text> ..
  44. Bingfang Yan; Fiscal Year: 2016
    ..The revision application proposes a set of studies to reveal the underlying mechanisms on how and to which extent the drug-eliminating capacity of an individual is altered by co-administered drugs or inflammatory mediators. ..
  45. Screening for Inhibitors of TLR8 for Treatment of Rheumatoid Arthritis
    Robert L Coffman; Fiscal Year: 2013
    ....
  46. Development of TLR8 inhibitors for treatment of autoimmune diseases
    Cristiana Guiducci; Fiscal Year: 2013
    ..If successful, the data generated will provide the groundwork for a full-scale development program for a TLR8 inhibitor for autoimmune diseases. ..
  47. Optoid Analgesics: Modulation of Trigeminal & Spinal Glial Activation
    Linda Watkins; Fiscal Year: 2010
    ..If successful, these studies will lead to development of novel adjunct therapies for improving clinical pain control by controlling the negative consequences of opioid-induced glial activation. ..
  48. Wenshu Chen; Fiscal Year: 2014
    ..Recent studies highlight Interleukin 6 (IL-6) as playing a central role in the development of lung cancer...
  49. Depression, Stress, Aging & Proinflammatory Cytokines
    Janice Kiecolt Glaser; Fiscal Year: 2009
    ..The proposed study will expand our knowledge of how genetic polymorphisms interact with environmental stressors to enhance risk for adverse mental and physical health changes. ..
  50. Hexin Chen; Fiscal Year: 2016
    ..Successful completion of this study will help us understand the mechanism and functions of HER2-induced IL1 and IL6 cytokines in the generation and maintenance of the CSC population both in vitro and in vivo. ..
  51. Stem Cell Quality Assays: Correlation with Aging/Health
    JOHN GRAHAM SHARP; Fiscal Year: 2010
    ..altered balance of pro- and anti-inflammatory cytokines, Aim #2 will analyze blood from the same patients for interleukin 6, tumor necrosis factor, transforming growth factor beta and insulin-like growth factor one levels along with ..
  52. LH ACTION IN OVARIAN CELL DIFFERENTIATION
    JoAnne S Richards; Fiscal Year: 2013
    ..Test the hypotheses that specific matrix factors, IL6 and innate immune cell-related genes expressed in cumulus cells direct the unique fate of these cells. ..
  53. Jenny P Ting; Fiscal Year: 2015
    ..This proposal plans to examine the roles of ASC and these other NLRs in these disease models. We will further delineate the molecular mechanisms by which these proteins affect disease outcome. ..
  54. Neural estrogen synthesis by astrocytic aromatization, and neuroinflammation.
    Colin J Saldanha; Fiscal Year: 2013
    ..These data are necessary for the development of therapies that target and prevent inflammatory processes, thereby reducing the severity of neurodegenerative disease. ..
  55. BIOMEDICAL (BASIC)
    ANNECLAIRE DEROOS; Fiscal Year: 2009
    ..After carefully characterizing this pathway, these data will become a useful resource for future studies of NHL in the WHI. ..
  56. Xiaolin Zi; Fiscal Year: 2014
    ..Our studies will determine if the proposed molecular target is correct, and may point to other enzymes and cytokines as potential targets of lycopene. ..
  57. Effects of GSH +/- Arginine on Markers of Inflammation Among Adults with CVD Risk
    Christopher D Gardner; Fiscal Year: 2010
    ..Primary study outcomes are serum markers of inflammation including monocyte chemoattractant protein-1 (MCP-1), interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-1) and soluble intercellular adhesion molecule-1 (sICAM-1)...
  58. A Prospective Study of Adiposity and Subclinical Coronary Artery Disease
    CHRISTINA LYNN WASSEL; Fiscal Year: 2010
    ....
  59. Loss of fat tissue and functional responses to exercise in older, obese adults
    Barbara J Nicklas; Fiscal Year: 2013
    ....
  60. The role of IL-6 in jet fuel irritant dermatitis
    RANDLE MICHAEL GALLUCCI; Fiscal Year: 2010
    ..b>Interleukin 6 is a cytokine produced in skin that is closely associated with healing, and certain irritant chemicals such as ..
  61. Lipoic Acid and Omega-3 Fatty Acids in Alzheimer's Disease
    LYNNE H SHINTO; Fiscal Year: 2012
    ..3, is to collect preliminary data on a panel of serum and plasma biologic markers: tumor necrosis factor alpha;interleukin 6;osteoprotegerin;cholesterol;triglycerides;LDL;HDL;24S-hydroxycholesterol...
  62. Jill M Wecht; Fiscal Year: 2014
    ....
  63. Michael Sobel; Fiscal Year: 2015
    ....
  64. Disparities in Breast Cancer: Development and Survival in Hispanic and NHW Women
    Martha L Slattery; Fiscal Year: 2013
    ..These genetic factors will be evaluated with survival to determine their contribution to survival differences observed for Hispanic and NHW women. ..
  65. Diet, Activity, and Lifestyle as a Risk Factor for Colorectal Cancer
    Martha L Slattery; Fiscal Year: 2012
    ..Identification of polymorphisms or haplotypes that are relevant to colorectal cancer will advance our understanding of etiology, may lead to specific health recommendations, and can identify targets for drug therapy. ..
  66. Inflammation Pathways in Breast Cancer
    Margaret M Madeleine; Fiscal Year: 2010
    ..Cytokine genes are expressed at different levels in older compared to younger women;therefore, we will also evaluate their contribution to breast cancer risk by levels of common exposures such as obesity and HRT use. ..
  67. Frank B Hu; Fiscal Year: 2016
    ..insulin, adiponectin, retinol binding protein 4 [RBP4], tumor necrosis factor receptor 2 [TNF-R2], and interleukin 6 [IL-6]) among 1,000 healthy NHS II participants who provided repeated fasting bloods in 1996/1997 and 2011/..
  68. Suzanne C Segerstrom; Fiscal Year: 2016
    ..The study will advance understanding of how a common, age-relevant experience - physical pain - affects EWB and physical health. ..
  69. Inflamation and the Risk of Endometrial Cancer
    Akila Viswanathan; Fiscal Year: 2010
    ..This proposal will ensure that she will become an established independent investigator and a leading expert in gynecologic cancer epidemiology. ..
  70. Biobehavioral Genetics of CVD Risk
    Indrani Halder; Fiscal Year: 2010
    ..The ROO phase will involve examining all genes for a comprehensive evaluation of the pathways (End of Abstract) ..
  71. Interleukin-6 Expression and Function in Adipose Cells
    Jianbei Deng; Fiscal Year: 2006
    ..The role of STAT3 in fat pad formation will be investigated by implantation into the subcutaneous space of nude mice human preadipocytes that express vector, PIAS3, or constitutively active STAT3. ..
  72. Regulation of PAF Acetylhydrolase Expression by Oxidized Phospholipids
    SUZANNE BARBOUR; Fiscal Year: 2009
    ..These interactions are proposed to induce interleukin 6 (IL6) and the phosphorylation and activation of key transcription factors, events essential for optimal ..
  73. STRUCTURE AND REGULATION OF LIVER ACUTE PHASE GENES
    Neil Cooper; Fiscal Year: 1993
    ..Transcription of both genes is controlled by glucocorticoids and interleukin 6 (IL6) in opposite directions...
  74. PROLIFERATIVE CONDITIONING OF TUMOR-COMPETENT DENDRITIC CELL PRECURSORS
    Peter A Cohen; Fiscal Year: 2010
    ..This project aims to provide the information needed to bring this research to a clinical trial for treating cancer patients. ..
  75. MECHANISM OF CYTOKINE INDUCED B CELL DIFFERENTIATION
    Selina Chen Kiang; Fiscal Year: 2000
    ..These studies should provide significant insight into the the mechanisms that underlie cytokine signaling in the immune system and terminal differentiation of B cells. ..
  76. Regulation of the Human MDR1 Gene
    Branimir Sikic; Fiscal Year: 2005
    ..The focus will be on acute myeloid leukemia (AML) as a clinical model for MDR1 expression. MDR1 will be analyzed by rtPCR and flow cytometry. NF-IL6 members will be quantitatively analyzed in both nudear and cytoplasmic extracts of AML. ..
  77. Therapeutic use of small-molecule HGF-mimetic for emphysema
    BERT J W M OEHLEN; Fiscal Year: 2010
    ..Recent studies suggest that hepatocyte growth factor (HGF), a pleiotropic cytokine, has multiple activities that lead to lung regeneration...
  78. Pilot Clinical Study in Renal Transplantation
    Weizhong Cai; Fiscal Year: 2010
    ..Hepatocyte growth factor (HGF), also known as scatter factor (CF), is a renotrophic growth factor that exerts tissue protective and tissue ..
  79. Novel Small Molecules For Acute Liver Failure
    Prakash Narayan; Fiscal Year: 2009
    ..Significant evidence suggests that scatter factor / hepatocyte growth factor (SF/HGF), exerts direct hepatoprotective effects and can potentially be used as a therapeutic in ALF...
  80. Anti-Fibrotic Therapy for Pulmonary Fibrosis
    Latha Paka; Fiscal Year: 2007
    ..Recent studies have identified hepatocyte growth factor (HGF) as an antifibrogenic agent that protects against transforming growth factor (TGFbeta) mediated apoptotic effects ..
  81. IMPROVED METHODS FOR IN VIVO HEPATIC GENE THERAPY
    KATHERINE PONDER; Fiscal Year: 2006
    ..We have demonstrated during the previous funding period that hepatocyte growth factor (HGF) can efficiently induce hepatocyte replication in rodents...
  82. Safety and PK Study in Hepatic Impairment Patients
    Weizhong Cai; Fiscal Year: 2010
    ..Hepatic growth factor (HGF), as known as scatter factor (SF), has been shown to be efficacious in reducing both liver fibrosis (chronic) and ..
  83. ROLE OF STROMA IN MAMMARY GLAND CELL PROLIFERATION
    SANDRA HASLAM; Fiscal Year: 2007
    ..In addition to P, these responses require mammary stroma derived-hepatocyte growth factor (HGF)...

Patents1

  1. Human interferon beta2A and interferon-beta2B, vectors containing genes coding for said interferons, cell lines producing same and use of said interferons as pharmaceuticals
    Patent Number: EP0220574-A1; Date:1987-05-06