IL-4

Summary

Gene Symbol: IL-4
Description: interleukin 4
Alias: BCGF-1, BCGF1, BSF-1, BSF1, IL-4, interleukin-4, B cell growth factor 1, B_cell stimulatory factor 1, binetrakin, interleukin 4 variant 2, lymphocyte stimulatory factor 1, pitrakinra
Species: human

Top Publications

  1. ncbi Ethnic differences of polymorphisms in cytokine and innate immune system genes in pregnant women
    Daniel P Nguyen
    Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Obstet Gynecol 104:293-300. 2004
  2. ncbi IL-4/IL-13 pathway genetics strongly influence serum IgE levels and childhood asthma
    Michael Kabesch
    University Children s Hospital Munich, Germany
    J Allergy Clin Immunol 117:269-74. 2006
  3. doi Association analysis of polymorphisms in IL-3, IL-4, IL-5, IL-9, and IL-13 with Graves' disease
    W Zhu
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Key Laboratory for Endocrine Tumors, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P R China
    J Endocrinol Invest 33:751-5. 2010
  4. pmc Requirement for IL-13 independently of IL-4 in experimental asthma
    G Grunig
    Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94143, USA
    Science 282:2261-3. 1998
  5. ncbi Interleukins-1, -4, -6, -10, tumor necrosis factor, transforming growth factor-beta, FAS, and mannose-binding protein C gene polymorphisms in Australian women: Risk of preterm birth
    Margaret F Annells
    Department of Microbiology and Infectious Diseases, Women s and Children s Hospital, North Adelaide, South Australia
    Am J Obstet Gynecol 191:2056-67. 2004
  6. pmc Intracellular Tat of human immunodeficiency virus type 1 activates lytic cycle replication of Kaposi's sarcoma-associated herpesvirus: role of JAK/STAT signaling
    Yi Zeng
    Department of Microbiology and Immunology, Nanjing Medical University, Nanjing 210029, People s Republic of China
    J Virol 81:2401-17. 2007
  7. ncbi RANTES -28G delays and DC-SIGN - 139C enhances AIDS progression in HIV type 1-infected Japanese hemophiliacs
    Yusuke Koizumi
    Department of Viral Infection and International Health, Graduate School of Medical Science, Kanazawa University, Kanazawa 920 8640, Japan
    AIDS Res Hum Retroviruses 23:713-9. 2007
  8. ncbi A complete screening of the IL4 gene: novel polymorphisms and their association with asthma and IgE in childhood
    Michael Kabesch
    University Children s Hospital of Munich, Germany
    J Allergy Clin Immunol 112:893-8. 2003
  9. pmc Impact of cytokines on replication in the thymus of primary human immunodeficiency virus type 1 isolates from infants
    Livia Pedroza-Martins
    Department of Microbiology, Immunology, and Molecular Genetics, UCLA AIDS Institute, USA
    J Virol 76:6929-43. 2002
  10. ncbi Involvement of T(H)1/T(H)2 cytokines in the pathogenesis of autoimmune skin disease-Pemphigus vulgaris
    Abhigyan Satyam
    Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India
    Immunol Invest 38:498-509. 2009

Research Grants

  1. Mouse models for the functional analysis of asthma-associated human polymorphisms
    Donata Vercelli; Fiscal Year: 2009
  2. Lisa M Coussens; Fiscal Year: 2015
  3. Jaroslaw Aronowski; Fiscal Year: 2016
  4. Jonathan Savitz; Fiscal Year: 2016
  5. Donata Vercelli; Fiscal Year: 2014
  6. A role for miRNAs in adenosine-dependent alternative macrophage activation
    Samuel Joseph Leibovich; Fiscal Year: 2013
  7. Involvement of Natural Killer T cells in Hepatic Fibrogenesis
    Ian N Hines; Fiscal Year: 2011
  8. Early Environmental Hygiene and Pediatric Asthma
    Christine C Johnson; Fiscal Year: 2009
  9. Mechanisms of Virus-Induced Hyperreactivity in Atopics
    David B Jacoby; Fiscal Year: 2010
  10. Paula C Bickford; Fiscal Year: 2016

Detail Information

Publications260 found, 100 shown here

  1. ncbi Ethnic differences of polymorphisms in cytokine and innate immune system genes in pregnant women
    Daniel P Nguyen
    Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Obstet Gynecol 104:293-300. 2004
    ..Differences in allelic carriage of immune system-related genes among white, black, and Hispanic pregnant women living in New York City and Boston were evaluated...
  2. ncbi IL-4/IL-13 pathway genetics strongly influence serum IgE levels and childhood asthma
    Michael Kabesch
    University Children s Hospital Munich, Germany
    J Allergy Clin Immunol 117:269-74. 2006
    ..IgE production, a hallmark of asthma and atopic disease, may be under genetic control. Genes of the IL-4 and IL-13 pathway, central for IgE regulation, have so far only been assessed in studies of single gene effects...
  3. doi Association analysis of polymorphisms in IL-3, IL-4, IL-5, IL-9, and IL-13 with Graves' disease
    W Zhu
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Key Laboratory for Endocrine Tumors, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P R China
    J Endocrinol Invest 33:751-5. 2010
    ..The aim of the present study is to elucidate whether the single nucleotide polymorphisms (SNP) and the interaction of variants in the 5 genes are associated with the development of GD and Graves' ophthalmopathy (GO)...
  4. pmc Requirement for IL-13 independently of IL-4 in experimental asthma
    G Grunig
    Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94143, USA
    Science 282:2261-3. 1998
    ..This pathway may underlie the genetic associations of asthma with both the human 5q31 locus and the IL-4 receptor...
  5. ncbi Interleukins-1, -4, -6, -10, tumor necrosis factor, transforming growth factor-beta, FAS, and mannose-binding protein C gene polymorphisms in Australian women: Risk of preterm birth
    Margaret F Annells
    Department of Microbiology and Infectious Diseases, Women s and Children s Hospital, North Adelaide, South Australia
    Am J Obstet Gynecol 191:2056-67. 2004
    ..The purpose of this study was to examine the relationship between preterm birth and 22 single nucleotide polymorphisms in genes that encode cytokines and mediators of apoptosis and host defense...
  6. pmc Intracellular Tat of human immunodeficiency virus type 1 activates lytic cycle replication of Kaposi's sarcoma-associated herpesvirus: role of JAK/STAT signaling
    Yi Zeng
    Department of Microbiology and Immunology, Nanjing Medical University, Nanjing 210029, People s Republic of China
    J Virol 81:2401-17. 2007
    ..These findings suggest that Tat may participate in KS pathogenesis by inducing KSHV replication and increasing KSHV viral load. These data also suggest that JAK/STAT signaling may be of therapeutic value in AIDS-related KS patients...
  7. ncbi RANTES -28G delays and DC-SIGN - 139C enhances AIDS progression in HIV type 1-infected Japanese hemophiliacs
    Yusuke Koizumi
    Department of Viral Infection and International Health, Graduate School of Medical Science, Kanazawa University, Kanazawa 920 8640, Japan
    AIDS Res Hum Retroviruses 23:713-9. 2007
    ..These results suggest that RANTES -28G was associated with delayed AIDS progression, while DC-SIGN -139C was associated with accelerated AIDS progression in HIV-1-infected Japanese hemophiliacs...
  8. ncbi A complete screening of the IL4 gene: novel polymorphisms and their association with asthma and IgE in childhood
    Michael Kabesch
    University Children s Hospital of Munich, Germany
    J Allergy Clin Immunol 112:893-8. 2003
    ..Polymorphism C-589T was reported to influence total serum IgE levels and bronchial hyperresponsiveness. However, no study has investigated the putative existence of further SNPs in exons, introns, and flanking regions of the IL4 gene...
  9. pmc Impact of cytokines on replication in the thymus of primary human immunodeficiency virus type 1 isolates from infants
    Livia Pedroza-Martins
    Department of Microbiology, Immunology, and Molecular Genetics, UCLA AIDS Institute, USA
    J Virol 76:6929-43. 2002
    ..Our studies suggest that coreceptor use by HIV primary isolates is important but is not the sole determinant of HIV pathogenesis in the thymus...
  10. ncbi Involvement of T(H)1/T(H)2 cytokines in the pathogenesis of autoimmune skin disease-Pemphigus vulgaris
    Abhigyan Satyam
    Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India
    Immunol Invest 38:498-509. 2009
    ..The decreased levels of IL-2 and IFN-gamma might demonstrate the inhibitory effects by IL-4 and IL-10, which suppress the expansion of T(H)1 population...
  11. doi Differential requirements for IL-4/STAT6 signalling in CD4 T-cell fate determination and Th2-immune effector responses
    Elizabeth Forbes
    Malaghan Institute of Medical Research, Wellington, New Zealand
    Immunol Cell Biol 88:240-3. 2010
    ....
  12. pmc IL-4 and TGF-beta 1 counterbalance one another while regulating mast cell homeostasis
    Matthew R Macey
    Virginia Commonwealth University, Biology Department, Box 842012, Richmond, VA 23284 2012, USA
    J Immunol 184:4688-95. 2010
    ..Dysregulation of this balance may impact allergic disease and be amenable to targeted therapy...
  13. pmc Inhibition of suppressive T cell factor 1 (TCF-1) isoforms in naive CD4+ T cells is mediated by IL-4/STAT6 signaling
    Elisabeth Maier
    Department of Molecular Biology, University of Salzburg, Hellbrunner Strasse 34, A 5020 Salzburg, Austria
    J Biol Chem 286:919-28. 2011
    ..Thus, this study provides a model for an IL-4/STAT6-dependent fine tuning mechanism of TCF-1-driven T helper cell polarization...
  14. pmc Therapeutic immunization with HIV-1 Tat reduces immune activation and loss of regulatory T-cells and improves immune function in subjects on HAART
    Barbara Ensoli
    National AIDS Center, Istituto Superiore di Sanita, Rome, Italy
    PLoS ONE 5:e13540. 2010
    ..In contrast, these changes were opposite, absent or partial in the OBS population. These findings support the use of Tat immunization to intensify HAART efficacy and to restore immune homeostasis...
  15. doi IL-4 and IL-13 alter plasmacytoid dendritic cell responsiveness to CpG DNA and herpes simplex virus-1
    Jurjen Tel
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Invest Dermatol 131:900-6. 2011
    ..Taken together, these results demonstrate that T(h)2 cytokines are involved in the modulation of pDC function and responsiveness to bacterial- and viral-derived stimuli...
  16. doi Der p 1 suppresses indoleamine 2, 3-dioxygenase in dendritic cells from house dust mite-sensitive patients with asthma
    Kittipong Maneechotesuwan
    Division of Respiratory Disease and Tuberculosis, Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
    J Allergy Clin Immunol 123:239-48. 2009
    ..Indoleamine 2, 3-dioxygenase (IDO), a tryptophan-degrading enzyme in dendritic cells (DCs), mediates an immunosuppressive effect on activated T lymphocytes. However, little is known about the effect of Der p 1 on IDO in human DCs...
  17. pmc Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities
    T Yokota
    Proc Natl Acad Sci U S A 83:5894-8. 1986
    ..These results indicate that this human cDNA clone encodes a protein structurally and functionally homologous to mouse BSF-1...
  18. pmc Human immunodeficiency virus type 1 gp120 induces anergy in human peripheral blood lymphocytes by inducing interleukin-10 production
    D Schols
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium
    J Virol 70:4953-60. 1996
    ....
  19. ncbi Protective effect of interleukin-4 -589T polymorphism on human immunodeficiency virus type 1 disease progression: relationship with virus load
    Emi E Nakayama
    Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita Shi, Osaka 565 0871, Japan
    J Infect Dis 185:1183-6. 2002
    ..04). Adjustment for early serum virus load greatly diminished the strength of this association. These results suggest that IL-4 -589T protects against HIV-1 disease progression by reducing virus load...
  20. doi Reciprocal role of GATA-1 and vitamin D receptor in human myeloid dendritic cell differentiation
    Florian Göbel
    Institute of Immunology, Center of Physiology, Pathophysiology, and Immunology, Medical University of Vienna, Vienna, Austria
    Blood 114:3813-21. 2009
    ..GATA-1 mediates the repression of VDR and enables IL-4-dependent moDC differentiation. Conversely, VDR is induced downstream of transforming growth factor beta1 and is functionally involved in promoting LC differentiation...
  21. pmc Variation in cytokine genes can contribute to severity of acetabular osteolysis and risk for revision in patients with ABG 1 total hip arthroplasty: a genetic association study
    Jiri Gallo
    Department of Orthopaedics, Teaching Hospital and Faculty of Medicine and Dentistry, Palacky University, I P Pavlova 6, Olomouc775 20, Czech Republic Laboratory of Immunogenomics, Faculty of Medicine and Dentistry, Palacky University, I P Pavlova 6, Olomouc 775 20, Czech Republic
    BMC Med Genet 10:109. 2009
    ..This may be driven by functional polymorphisms in the genes for cytokines and cytokine receptors involved in the development of osteolysis in THA, thereby having an effect on the individual's phenotype...
  22. pmc Early growth response protein-1 (Egr-1) is preferentially expressed in T helper type 2 (Th2) cells and is involved in acute transcription of the Th2 cytokine interleukin-4
    Michael Lohoff
    Tumor Immunology Program D030, German Cancer Research Center DKFZ, D 69120 Heidelberg, Germany
    J Biol Chem 285:1643-52. 2010
    ..Our study provides the first evidence that Egr-1 protein is differentially expressed in Th1 and Th2 cells and is involved in the acute phase of the IL-4 transcription in response to TCR stimulation...
  23. doi Adipose derived stem cells (ASCs) isolated from breast cancer tissue express IL-4, IL-10 and TGF-β1 and upregulate expression of regulatory molecules on T cells: do they protect breast cancer cells from the immune response?
    Mahboobeh Razmkhah
    Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran
    Cell Immunol 266:116-22. 2011
    ..Further investigation is required to see if the immune suppression induced by ASCs is an independent property from tumor cells or ASCs gain their immunosuppressive potential from malignant cells...
  24. pmc The involvement of interleukin-1 and interleukin-4 in the response of human annulus fibrosus cells to cyclic tensile strain: an altered mechanotransduction pathway with degeneration
    Hamish T J Gilbert
    School of Biomedicine, Faculty of Medical and Human Sciences, University of Manchester, Manchester M139PL, UK
    Arthritis Res Ther 13:R8. 2011
    ....
  25. doi Association of interleukin 4 -589T/C polymorphism with T(H)1 and T(H)2 bias and sepsis in Chinese major trauma patients
    Wei Gu
    State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China
    J Trauma 71:1583-7. 2011
    ..Whether this genetic variation is associated with sepsis susceptibility is unknown. The aim of this study was to search for the association of IL-4 -589T/C with the susceptibility to sepsis...
  26. pmc HIV-1 coinfection and morphine coexposure severely dysregulate hepatitis C virus-induced hepatic proinflammatory cytokine release and free radical production: increased pathogenesis coincides with uncoordinated host defenses
    Nazira El-Hage
    Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, 1217 East Marshall Street, Richmond, VA 23298 0613, USA
    J Virol 85:11601-14. 2011
    ..The results suggest that opioid abuse and HIV-1 coinfection each further accelerate HCV-mediated liver disease by dysregulating immune defenses...
  27. doi Upregulated protein arginine methyltransferase 1 by IL-4 increases eotaxin-1 expression in airway epithelial cells and participates in antigen-induced pulmonary inflammation in rats
    Qingzhu Sun
    Department of Genetics and Molecular Biology, Xi an Jiaotong University College of Medicine, Xi an, Shaanxi 710061, China
    J Immunol 188:3506-12. 2012
    ..The findings may provide experimental evidence that PRMT1 plays an important role in asthma pathogenesis...
  28. ncbi Analysis of allelic expression patterns of IL-2, IL-3, IL-4, and IL-13 in human CD4+ T cell clones
    Jean Pierre Bayley
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 33:2142-8. 2003
    ..The gene for IL-4 showed an imbalance in expression from each allele, indicating differential expression of IL-4 alleles within or between IL-4-expressing cells...
  29. ncbi IL-4 and IL-13 induce protection of porcine endothelial cells from killing by human complement and from apoptosis through activation of a phosphatidylinositide 3-kinase/Akt pathway
    John F Grehan
    Department of Surgery, University of Minnesota School of Medicine, Minneapolis, MN 55455, USA
    J Immunol 175:1903-10. 2005
    ..We conclude that IL-4 and IL-13 can induce protection of porcine EC against killing by apoptosis and human complement through activation of the PI3K/Akt signaling pathway...
  30. pmc Regulation of eotaxin-3/CCL26 expression in human monocytic cells
    Victoria E L Stubbs
    Department of Physiology, University of Calgary, Alberta, Canada
    Immunology 130:74-82. 2010
    ..These data show that IL-4 and pro-inflammatory cytokines such as TNF-alpha, IL-1beta and IFN-gamma regulate CCL26 synthesis in human monocytic cells, which may be important in regulating monocyte inflammatory responses...
  31. ncbi Expression of 15-lipoxygenase type-1 in human mast cells
    Magdalena Gulliksson
    The Institute of Environmental Medicine, Division of Physiology, Unit for Experimental Asthma and Allergy Research, Karolinska Institutet, P O Box 287, SE 171 77 Stockholm, Sweden
    Biochim Biophys Acta 1771:1156-65. 2007
    ..In conclusion, the expression of 15-LO-1 and release of 15-LO-1 derived products by mast cells may contribute to the role of these cells in asthma and other inflammatory diseases...
  32. ncbi Induction of lytic cycle replication of Kaposi's sarcoma-associated herpesvirus by herpes simplex virus type 1: involvement of IL-10 and IL-4
    Di Qin
    Laboratory of Reproductive Medicine, Key Laboratory of Pathogen Biology of Jiangsu Province, and Department of Microbiology and Immunology, Nanjing Medical University, Nanjing 210029, China
    Cell Microbiol 10:713-28. 2008
    ..Our data present the first direct evidence that HSV-1 can activate KSHV lytic replication and suggest a role of HSV-1 in KSHV pathogenesis...
  33. ncbi Differential expression of cytokine genes in HIV-1 tat transfected T and B cell lines
    V Sharma
    Division of Hematology and Oncology, Arthur G James Cancer Hospital and Research Institute, Ohio State University, Columbus 43210
    Biochem Biophys Res Commun 208:704-13. 1995
    ....
  34. ncbi Herpes simplex virus type 1 infection induces upregulation of interleukin-23 (p19) mRNA expression in trigeminal ganglia of BALB/c mice
    Eeva K Broberg
    Department of Virology, the MediCity Research Laboratory, and the Turku Graduate School of Biomedical Sciences, University of Turku, FIN 20520 Turku, Finland
    J Interferon Cytokine Res 22:641-51. 2002
    ..This is, to our knowledge, the first report to show elevated expression of IL-23 (p19) mRNA (p < 0.05) during viral infection in TG of mice...
  35. ncbi HIV-1 matrix protein p17 enhances the proliferative activity of natural killer cells and increases their ability to secrete proinflammatory cytokines
    Marco Vitale
    Department of Anatomy, Pharmacology and Forensic Medicine, Ospedale Maggiore, University of Parma, Italy
    Br J Haematol 120:337-43. 2003
    ..The property of p17 to increase the production of TNF-alpha and IFN-gamma might be a mechanism used by HIV-1 to modulate the immune system to support its replication and spreading...
  36. ncbi Association of non-HLA genes with type 1 diabetes autoimmunity
    Andrea K Steck
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Mail Stop A140, P O Box 6511, Aurora, CO 80045 6511, USA
    Diabetes 54:2482-6. 2005
    ..Genes involved in the IL-4 regulatory pathway (IL-4, IL-4R, IL-13) may confer susceptibility or protection to type 1 diabetes depending on individual SNPs or specific haplotypes...
  37. ncbi Protective effects of IL4-589T and RANTES-28G on HIV-1 disease progression in infected Thai females
    Nuanjun Wichukchinda
    National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand
    AIDS 20:189-96. 2006
    ..To evaluate the effect of polymorphisms in interleukin-4 (IL4) and RANTES promoters on disease progression in HIV-1 infected Thais...
  38. doi Sustained IL-1alpha, IL-4, and IL-6 elevations following correction of hyperglycemia in children with type 1 diabetes mellitus
    Jaime S Rosa
    Department of Pharmacology, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA
    Pediatr Diabetes 9:9-16. 2008
    ....
  39. doi Gene expression polymorphisms of interleukins-1 beta, -4, -6, -8, -10, and tumor necrosis factors-alpha, -beta: regression analysis of their effect upon oral squamous cell carcinoma
    Eleftherios Vairaktaris
    Department of Maxillofacial Surgery, University of Athens Medical School, Attikon Hospital, Rimini 1, 12462, Athens, Greece
    J Cancer Res Clin Oncol 134:821-32. 2008
    ..The present retrospective case-control study examines possible interactions between seven cytokine genotype polymorphisms and their combinatory effect in predicting the occurrence of OSCC in Caucasians...
  40. doi Association of interleukin-4 and interleukin-1 receptor antagonist gene polymorphisms and risk of benign prostatic hyperplasia
    Rituraj Konwar
    Division of Endocrinology, Central Drug Research Institute, Lucknow, India
    Urology 71:868-72. 2008
    ..The purpose of this study was to investigate the genetic association of polymorphisms of important cytokine genes (IL-4 and IL-1Ra) with the risk of BPH in a case-control study of a North Indian population...
  41. doi IL-4-mediated fine tuning of IL-12p70 production by human DC
    Emmanuella Guenova
    Department of Dermatology, Eberhard Karls University, Tubingen, Germany
    Eur J Immunol 38:3138-49. 2008
    ..Thus, we demonstrate that the Th2 cell cytokine IL-4 decisively determines the phenotype of ongoing immune responses by orchestrating the functional phenotype of newly immigrating DC precursors...
  42. doi T-helper 1, T-helper 2, and T-regulatory cytokines gene polymorphisms in irritable bowel syndrome
    Elham Barkhordari
    Molecular Immunology Research Center and Immunogenetic Laboratory, Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
    Inflammation 33:281-6. 2010
    ..001). While production of cytokines could be affected by genetic polymorphisms within coding and promoter regions of cytokine genes, IL-4 and IL-10 gene polymorphisms could affect individual susceptibility to IBS...
  43. pmc P110delta, a novel phosphoinositide 3-kinase in leukocytes
    B Vanhaesebroeck
    Ludwig Institute for Cancer Research, 91 Riding House Street, London W1P 8BT, United Kingdom
    Proc Natl Acad Sci U S A 94:4330-5. 1997
    ..Possible selective functions of p110delta in white blood cells are discussed...
  44. ncbi The high-affinity interaction of human IL-4 and the receptor alpha chain is constituted by two independent binding clusters
    Jin Li Zhang
    Department of Physiological Chemistry II, Biocenter, University of Wuerzburg, Am Hubland, 97074 Wuerzburg, Germany
    J Mol Biol 315:399-407. 2002
    ..These results show that the high-affinity IL-4/IL4-BP contact is constituted by two independent binding units, each containing a central polar or charged side-chain surrounded by hydrophobic groups (avocado cluster)...
  45. ncbi Association of interleukin-4 and interleukin-1B gene variants with Larsen score progression in rheumatoid arthritis
    Stephane Genevay
    University Hospital of Geneva, Switzerland
    Arthritis Rheum 47:303-9. 2002
    ..To perform a genetic association study using markers in the interleukin-1 (IL-1) gene cluster and the IL-4/IL-4 receptor system genes, seeking evidence for involvement in the onset or the erosive outcome of rheumatoid arthritis (RA)...
  46. ncbi IL-4 protects tumor cells from anti-CD95 and chemotherapeutic agents via up-regulation of antiapoptotic proteins
    Concetta Conticello
    Department of Experimental Oncology, Mediterranean Institute of Oncology, Catania, Italy
    J Immunol 172:5467-77. 2004
    ..These findings may provide useful information for the development of therapeutic strategies aimed at restoring the functionality of apoptotic pathways in tumor cells...
  47. ncbi IL4-589C/T polymorphism and IgE levels in severe malaria
    Federica Verra
    Dipartimento di Scienze di Sanità Pubblica, Sezione di Parassitologia, WHO Collaborating Centre for Malaria Epidemiology and Control, Rome, Italy
    Acta Trop 90:205-9. 2004
    ..These results raise the possibility that there is a relationship between susceptibility to severe malaria, IgE production and genetic variation in the IL4 region, which merits further investigation in other epidemiological settings...
  48. ncbi Interferon-gamma inhibits STAT6 signal transduction and gene expression in human airway epithelial cells
    Nicola M Heller
    Division of Allergy and Clinical Immunology, Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland 21224, USA
    Am J Respir Cell Mol Biol 31:573-82. 2004
    ..These observations have important implications for the regulation of epithelial cell activation by the balance of Th1/Th2-type cytokines in the airways in allergic disease...
  49. ncbi IL-4-induced upregulation of adenine nucleotide translocase 3 and its role in Th cell survival from apoptosis
    Ji Young Jang
    Department of Biological Science and Institute for Basic Science, Sungkyunkwan University, Suwon 440 746, Republic of Korea
    Cell Immunol 241:14-25. 2006
    ..In contrast, siRNA knock-out of ANT3 expression induced T cell apoptosis and blocked the IL-4-mediated cell survival. Together these results suggest that ANT3 has a potential role in Th cell survival and immune cell homeostasis...
  50. ncbi Immunosuppression during active tuberculosis is characterized by decreased interferon- gamma production and CD25 expression with elevated forkhead box P3, transforming growth factor- beta , and interleukin-4 mRNA levels
    Teri Roberts
    Molecular Biology and Human Genetics, Department of Biomedical Sciences, University of Stellenbosch, Cape Town, 7505, South Africa
    J Infect Dis 195:870-8. 2007
    ..Together, these results suggest that immunosuppression seen after mycobacterial stimulation in case patients with active TB is associated with naturally occurring regulatory T cells...
  51. ncbi IL-4 protects the B-cell lymphoma cell line CH31 from anti-IgM-induced growth arrest and apoptosis: contribution of the PI-3 kinase/AKT pathway
    Gregory B Carey
    Program in Oncology, Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA
    Cell Res 17:942-55. 2007
    ..These results suggest that the IL-4 receptor activates several signaling pathways, with the Akt pathway playing a major role in suppression of the apoptotic program activated by anti-IgM...
  52. ncbi The interleukin-4 site-2 epitope determining binding of the common receptor gamma chain
    F Letzelter
    Theodor Boveri Institut für Biowissenschaften Biozentrum der Universität, Physiologische Chemie II, Wurzburg, Germany
    Eur J Biochem 257:11-20. 1998
    ..This site-2 affinity seems to be sufficient, however, to promote, in a second step, a productive association of gamma(c) to an IL-4/alpha chain complex in the membrane...
  53. ncbi Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface
    T Hage
    Institut für Physiologische Chemie II, Theodor Boveri Institut für Biowissen Schaften Biozentrum, Universitat Wurzburg, Germany
    Cell 97:271-81. 1999
    ..Novel insights on ligand binding in the cytokine receptor family and a paradigm for receptors of IL-2, IL-7, IL-9, and IL-15, which all utilize gamma c, are provided...
  54. ncbi Influence of patient and donor cytokine genotypes on renal allograft rejection: evidence from a single centre study
    K L Poole
    Histrocompatibility and Immunogenetics Laboratory, Southampton Unitversity Hospitals, UK
    Transpl Immunol 8:259-65. 2001
    ..However, due to conflicting results from this and other studies, a multi-centre collaborative study may be required to determine whether cytokine genotypes are significant, independent predictors of renal allograft rejection...
  55. ncbi Antimalarial antibody levels and IL4 polymorphism in the Fulani of West Africa
    G Luoni
    Fondazione Pasteur Cenci Bolognetti, Universita di Roma La Sapienza, Rome, Italy
    Genes Immun 2:411-4. 2001
    ..These data highlight the possibility of combining inter- and intra-ethnic comparisons to characterize critical determinants of malarial immunity in a natural setting...
  56. pmc Association and interaction of the IL4R, IL4, and IL13 loci with type 1 diabetes among Filipinos
    Teodorica L Bugawan
    Roche Molecular Systems, Alameda, CA 94501, USA
    Am J Hum Genet 72:1505-14. 2003
    ..Our data suggest that the risk for T1D is determined, in part, by polymorphisms within the IL4R locus, including promoter and coding-sequence variants, and by specific combinations of genotypes at the IL4R and the IL4 and IL13 loci...
  57. ncbi IL-4 inhibits cell cycle progression of human umbilical vein endothelial cells by affecting p53, p21(Waf1), cyclin D1, and cyclin E expression
    Jinkoo Kim
    Vascular System Research Center, Kangwon National University, Chunchon 200 701, Korea
    Mol Cells 16:92-6. 2003
    ..These results show that IL-4 inhibits endothelial cell growth by altering the expression of cell cycle regulatory molecules...
  58. ncbi A single-nucleotide substitution from C to T at position -1055 in the IL-13 promoter is associated with protection from severe malaria in Thailand
    J Ohashi
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Genes Immun 4:528-31. 2003
    ..An IL-13 -1055C>T has been reported to alter the regulation of IL-13 production. Thus, IL-13 -1055T may show resistance to severe malaria through the alteration of IL-13 production...
  59. ncbi Cytokine gene single nucleotide polymorphisms and susceptibility to and prognosis in cutaneous malignant melanoma
    W M Howell
    Department of Human Genetics, University of Southampton, UK
    Eur J Immunogenet 30:409-14. 2003
    ....
  60. ncbi Hepatic adducts, circulating antibodies, and cytokine polymorphisms in patients with diclofenac hepatotoxicity
    Guruprasad P Aithal
    School of Clinical Medical Sciences Hepatology, Medical School, University of Newcastle, Newcastle upon Tyne, United Kingdom
    Hepatology 39:1430-40. 2004
    ..In conclusion, the observed polymorphisms, resulting in low IL-10 and high IL-4 gene transcription, could favor a T helper (Th)-2 mediated antibody response to neoantigenic stimulation associated with disease susceptibility...
  61. ncbi Gene-gene interaction between interleukin-4 and interleukin-4 receptor alpha in Korean children with asthma
    S G Lee
    Asan Institute for Life Sciences, University of Ulsan, Seoul, Korea
    Clin Exp Allergy 34:1202-8. 2004
    ..Interleukin-4 receptor alpha (IL-4Ralpha), which binds IL-4 and IL-13, is involved in signal transduction of those cytokines that lead to IgE production, and is also a key functional component of the Th2 lymphocyte phenotype...
  62. pmc Allelic polymorphisms in the repeat and promoter regions of the interleukin-4 gene and malaria severity in Ghanaian children
    B A Gyan
    Immunology Unit, Noguchi Memorial Institute for Medical Research, Ghana
    Clin Exp Immunol 138:145-50. 2004
    ..Carriers of IL-4 +33T/-590T with cerebral malaria had elevated total IgE compared to non-carriers (P = 0.03). Our data suggest that IL-4 and/or IgE play a regulatory role in the pathogenesis of severe or complicated malaria...
  63. ncbi The -590 IL-4 promoter polymorphism in patients with rheumatoid arthritis
    Andrzej Pawlik
    Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, 70 111 Szczecin, ul Powst Wlkp 72, Poland
    Rheumatol Int 26:48-51. 2005
    ..We suggest that the IL-4 -590 promoter polymorphism may be a genetic risk factor for RA severity...
  64. ncbi Frequency of interleukin-4 (IL-4) -589 gene polymorphism and vaginal concentrations of IL-4, nitric oxide, and mannose-binding lectin in women with recurrent vulvovaginal candidiasis
    Oksana Babula
    Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Clin Infect Dis 40:1258-62. 2005
    ..Associations between this polymorphism and recurrent vulvovaginal candidiasis (RVVC), as well as vaginal concentrations of IL-4 and the anticandidal compounds nitric oxide (NO) and mannose binding lectin (MBL), were evaluated...
  65. ncbi Association of IL-1Ra gene polymorphism, but no association of IL-1beta and IL-4 gene polymorphisms, with Kawasaki disease
    Shu Fen Wu
    Department of Pediatrics, China Medical University Hospital, Taichung, Taiwan
    J Clin Lab Anal 19:99-102. 2005
    ..The genotype I/II for IL1-Ra and the frequency of allele II for IL1-Ra are associated with a higher susceptibility to KD, and thus may be useful markers for predicting the development of KD...
  66. ncbi Allelic polymorphisms in the interleukin-4 promoter regions and their association with bronchial asthma among the Russian population
    Y V Gervaziev
    V N Orekhovich s Institute of Biomedical Chemistry RAMS, Moscow, Russia
    Int Arch Allergy Immunol 141:257-64. 2006
    ..Susceptibility to the development of bronchial asthma (BA) and other atopic diseases is known to be associated with genetic components...
  67. ncbi Association between cord blood IgE and genetic polymorphisms of interleukin-4, the beta-subunit of the high-affinity receptor for IgE, lymphotoxin-alpha, and tumor necrosis factor-alpha
    Hui Ju Wen
    Department of Environmental and Occupational Health, National Cheng Kung University Medical College, Tainan, Taiwan
    Pediatr Allergy Immunol 17:489-94. 2006
    ..Our finding suggested a significant association of cbIgE with genetic polymorphism of IL-4 -590C/T, but not with the genotypes of FcepsilonRI-beta, LT-alpha, and TNF-alpha...
  68. ncbi Interferon gamma (IFNgamma) & interleukin-4 (IL-4) gene variants & cytokine levels in pulmonary tuberculosis
    M Vidyarani
    Tuberculosis Research Centre ICMR, Chennai, India
    Indian J Med Res 124:403-10. 2006
    ..The aim of our study was to find out whether Interferon gamma +874A and IL-4 -590T polymorphisms were associated with susceptibility to pulmonary tuberculosis as well as the level of IFNgamma and IL-4 in south Indian population...
  69. ncbi Ras/Erk pathway positively regulates Jak1/STAT6 activity and IL-4 gene expression in Jurkat T cells
    Eui Young So
    Laboratory of Immunology and Institute for Basic Science, Department of Biological Science, Sungkyunkwan University, 300 Cheon Cheon Dong, Jang An Ku, Suwon 440 746, Republic of Korea
    Mol Immunol 44:3416-26. 2007
    ..Together, the results indicate that there is a functional cross-talk between Ras/Erk and IL-4/Jak1/STAT6, which contributes to the regulation of IL-4 transcription in T cells...
  70. ncbi Interferon-gamma +874A/T and interleukin-4 intron3 VNTR gene polymorphisms in Chinese patients with idiopathic thrombocytopenic purpura
    Xiaoli Chen
    State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
    Eur J Haematol 79:191-7. 2007
    ....
  71. ncbi Single-nucleotide polymorphisms in selected cytokine genes and risk of adult glioma
    A V Brenner
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892 7238, USA
    Carcinogenesis 28:2543-7. 2007
    ..07 and 0.22, respectively). Our results underscore the importance of pooled analyses in genetic association studies and suggest that SNPs in cytokine genes may influence susceptibility to glioma...
  72. ncbi Role of genetically determined production of immunoregulatory cytokines in immunopathogenesis of chronic viral hepatitides
    I O Naslednikova
    Department of Pathophysiology, Siberian State Medical University, Federal Agency of Health Care and Social Development, Tomsk
    Bull Exp Biol Med 143:706-12. 2007
    ..The C/C genotype of the IL-10 gene promoter region C592A was shown to be a factor determining resistance to long-term persistence of hepatitis B and C viruses...
  73. ncbi Breast cancer risk associated with polymorphisms of IL-1RN and IL-4 gene in Indian women
    Rituraj Konwar
    Endocrinology Division, Central Drug Research Institute CDRI, Lucknow, India
    Oncol Res 17:367-72. 2009
    ..Further studies in other population are needed to confirm our findings and to elucidate the role of IL-1RN in progression of breast cancer...
  74. pmc Polymorphisms of some cytokines and chronic hepatitis B and C virus infection
    Qiu Ju Gao
    Department of Epidemiology, Public Health College, Hebei Medical University, Hebei Province, China
    World J Gastroenterol 15:5610-9. 2009
    ..To study the relationship between the polymorphisms in some cytokines and the outcome of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection...
  75. doi VEGF and IL-4 gene variability and its association with the risk of coronary heart disease in north Indian population
    R C Sobti
    Department of Biotechnology, Panjab University, Chandigarh 160014, India
    Mol Cell Biochem 341:139-48. 2010
    ..34, 95% CI 0.14-0.82, P < 0.01) and central obesity (OR 0.15, 95% CI 0.04-0.56, P < 0.001). GG genotype of VEGF has also shown significant association with IL-4 (P2P2 and P1P2) genotypes...
  76. pmc Candidate malaria susceptibility/protective SNPs in hospital and population-based studies: the effect of sub-structuring
    Nahid A Eid
    Department of Molecular Biology, Institute of Endemic Diseases, Medical Campus, Qasser Street, University of Khartoum, Khartoum, Sudan
    Malar J 9:119. 2010
    ....
  77. doi Effect of anti-inflammatory (IL-4, IL-10) cytokine genes in relation to risk of cervical carcinoma
    Mohammad Shekari
    Research Center for Molecular Medicine, Shariaty Hospital, Hormozgan University of Meical Science, Bandar Abbas, Iran
    Am J Clin Oncol 35:514-9. 2012
    ..The purpose of this study was to determine the relationship of different alleles of IL-4 and IL-10 genes with risk of cervical cancer among passive smokers and users of oral contraceptives...
  78. pmc IL-4 haplotype -590T, -34T and intron-3 VNTR R2 is associated with reduced malaria risk among ancestral indian tribal populations
    Aditya Nath Jha
    Centre for Cellular and Molecular Biology, CSIR, Hyderabad, India
    PLoS ONE 7:e48136. 2012
    b>Interleukin 4 (IL-4) is an anti-inflammatory cytokine, which regulates balance between T(H)1 and T(H)2 immune response, immunoglobulin class switching and humoral immunity...
  79. doi Association of polymorphisms in the interleukin-4 gene with response to hepatitis B vaccine and susceptibility to hepatitis B virus infection: a meta-analysis
    Wei Cui
    Department of Infectious Diseases, The First Affiliated Hospital of China Medical University, Liaoning, Shenyang 110001, China
    Gene 525:35-40. 2013
    ..The aim of this meta-analysis is to evaluate the associations between functional polymorphisms in the interleukin-4 (IL4) gene and individuals' responses to hepatitis B vaccine and their susceptibility to hepatitis B virus (HBV) infection...
  80. ncbi Human interleukin 4. The solution structure of a four-helix bundle protein
    L J Smith
    Inorganic Chemistry Laboratory, University of Oxford, England
    J Mol Biol 224:899-904. 1992
    ..m.r.) techniques have been used to determine the solution structure of human interleukin 4, a four-helix bundle protein...
  81. ncbi Polymorphisms of the interleukin-4 gene in chinese patients with systemic lupus erythematosus in Taiwan
    M C Wu
    Department of Medical Genetics, Division of Immunology and Rheumatology, China Medical College Hospital, Taichung, Taiwan
    Lupus 12:21-5. 2003
    ..The role of the intron 3 polymorphism of the IL4 gene in SLE remains unclear and further substantiation based on larger patient samples is needed...
  82. ncbi Polymorphisms in the IL-4 and IL-4R [alpha] genes and allergic asthma
    Tianpen Cui
    Immunology Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P R of China
    Clin Chem Lab Med 41:888-92. 2003
    ..16; p < 0.01), and also total plasma immunoglobulin E (IgE) level was increased in allergic asthma patients. These data suggest that the IL-4R alpha chain 576R/R genotypes confer genetic susceptibility to allergic asthma in Chinese...
  83. ncbi Polymorphisms of IL-4, IL-4R alpha, and AICDA genes in adult allergic asthma
    Tianpen Cui
    Immunology Laboratory, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022
    J Huazhong Univ Sci Technolog Med Sci 23:134-7. 2003
    ..127, respectively; P < 0.01)] and was correlated with the increased plasma total IgE. These data suggested that the IL-4R alpha chain 576R/R and AICDA 8408T/T genotypes confer genetic susceptibility to adult allergic asthma in China...
  84. ncbi Cytokines and chronic rejection: a study in kidney transplant long-term survivors
    Mariafederica Uboldi de Capei
    Genetics Institute, Department of Genetics, Biology and Biochemistry, University of Torino, Torino, Piemonte, Italy
    Transplantation 77:548-52. 2004
    ....
  85. ncbi Interleukin-4 gene intron-3 polymorphism is associated with transitional cell carcinoma of the urinary bladder
    Fuu Jen Tsai
    Department of Paediatrics, China Medical University Hospital, Taichung, Taiwan
    BJU Int 95:432-5. 2005
    ....
  86. ncbi Interleukin-4 gene, but not the interleukin-1 beta gene polymorphism, is associated with oral cancer
    Ming Hsui Tsai
    Department of Otolaryngology, China Medical University Hospital, Taichung, Taiwan
    J Clin Lab Anal 19:93-8. 2005
    ..However, whether the -590 C/T polymorphism of the IL4 gene plays a role in oral cancer remains unclear. Further substantiation based on larger patient samples is needed...
  87. ncbi Relationship between cytokines gene polymorphism and susceptibility to hepatitis B virus intrauterine infection
    Qi Rong Zhu
    Department of Infection Disease, Children s Hospital, Fudan University, Shanghai 200032, China
    Chin Med J (Engl) 118:1604-9. 2005
    ....
  88. ncbi Elevated interleukin-4 expression in severe recurrent hepatitis C virus after liver transplantation
    Sebastien Dharancy
    Laboratoire de Biologie Cellulaire, UPRES 1833, Faculté de Médecine Cochin Port Royal, Universite Paris 5, Paris, France
    Transplantation 83:906-11. 2007
    ..HCV frequently recurs after liver transplantation, and its course is accelerated in this setting. We compared in situ expression of IL-2 and IL-4 in transplanted and nontransplanted patients with HCV...
  89. ncbi Genetic association of interleukin-4, interleukin-10, and transforming growth factor-beta gene polymorphism with allograft function in renal transplant patients
    M Amirzargar
    Kidney Transplant Division, Ekbatan Hospital, Hamadan University of Medical Sciences, Tehran, Iran
    Transplant Proc 39:954-7. 2007
    ..TGF-beta codon 10 T allele was 39% in RE, 35% in SGF, and 53% in control group. In conclusion, this study suggested that some cytokine gene alleles reflected SGF among kidney transplant recipients...
  90. ncbi Allergies, variants in IL-4 and IL-4R alpha genes, and risk of pancreatic cancer
    Sara H Olson
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cancer Detect Prev 31:345-51. 2007
    ..Although genes have been identified that are critical in allergic response, polymorphisms in these genes have not been studied in relation to risk of pancreatic cancer. We hypothesized that variants in these genes are related to risk...
  91. doi Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4
    Matilde Todaro
    Department of Surgical and Oncological Sciences, Cellular and Molecular Pathophysiology Laboratory, University of Palermo, 90127 Palermo, Italy
    Cell Stem Cell 1:389-402. 2007
    ..Our data suggest that colon tumor growth is dictated by stem-like cells that are treatment resistant due to the autocrine production of IL-4...
  92. doi Endogenous interleukin-4 promotes tumor development by increasing tumor cell resistance to apoptosis
    Zhiguang Li
    National Laboratory of Biomacromolecules, Chinese Academy of Sciences University of Tokyo Joint Laboratory of Structural Virology and Immunology, Graduate School of Chinese Academy of Sciences, Institute of Biophysics, Beijing, China
    Cancer Res 68:8687-94. 2008
    ..These findings were helpful to understand the long clinical observation and revealed that endogenous IL-4, the product of host immune response, can be used by tumor cells to facilitate their growth...
  93. pmc Genetic polymorphisms in the cytokine genes and risk of hepatocellular carcinoma in low-risk non-Asians of USA
    Simona Ognjanovic
    Department of Pediatrics, Division of Pediatric Epidemiology and Clinical Research, University of Minnesota, MMC 715, 420 Delaware Street S E, Minneapolis, MN 55455, USA
    Carcinogenesis 30:758-62. 2009
    ..98, 95% CI = 0.50-7.84, P = 0.08). In contrast to high-risk Chinese, Th1 and Th2 genotypes did not impact in a major way on risk of HCC in USA non-Asians...
  94. pmc Association of the gene polymorphisms IFN-gamma +874, IL-13 -1055 and IL-4 -590 with patterns of reinfection with Schistosoma mansoni
    Michael R Gatlin
    University of Georgia, Athens, Georgia, United States of America
    PLoS Negl Trop Dis 3:e375. 2009
    ....
  95. doi Oct-1 is responsible for the C-33T polymorphism effect in the IL-4 promoter
    Y V Gervaziev
    I I Mechnikov s Institute of Vaccines and Sera RAMS, Moscow, Russia
    Int J Immunogenet 37:13-20. 2010
    ..Our findings suggest that the interplay between Oct-1 and unknown TFs may be responsible for the C-33T polymorphism effects...
  96. pmc IL4 gene polymorphism and previous malaria experiences manipulate anti-Plasmodium falciparum antibody isotype profiles in complicated and uncomplicated malaria
    Piyatida Tangteerawatana
    Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    Malar J 8:286. 2009
    ..falciparum IgG subclasses and IgE antibodies levels and the alteration of malaria severity in complicated and uncomplicated malaria patients with or without previous malaria experiences...
  97. ncbi Allelic polymorphism of cytokine genes during pulmonary tuberculosis
    I O Naslednikova
    Department of Pathophysiology, Department of Phthisiology and Pulmonology, Siberian State Medical University, Federal Agency of Health Care and Social Development, Tomsk, Russia
    Bull Exp Biol Med 148:175-80. 2009
    ....
  98. doi Interleukin-4 gene polymorphisms confer Behçet's disease in Turkish population
    H B Oral
    Department of Medical Microbiology, Immunology Unit, Uludag University Faculty of Medicine, Bursa, Turkey
    Scand J Immunol 73:594-601. 2011
    ..However, in order to confirm and assess the association of IL-4 and IL-4Rα gene polymorphisms with the BD, large cohort studies are needed...
  99. ncbi Association of interleukin-2, interleukin-4 and transforming growth factor-beta gene polymorphisms with Behcet's disease
    Farhad Shahram
    Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran
    Clin Exp Rheumatol 29:S28-31. 2011
    ..Cytokine single nucleotide polymorphisms could play a role in the pathophysiology of BD. The results of this study could suggest a tendency towards higher production of IL-2 and lower production of IL-4 in the patients with BD...
  100. pmc Gene-vitamin D interactions on food sensitization: a prospective birth cohort study
    X Liu
    Mary Ann and J Milburn Smith Child Health Research Program, Children s Memorial Hospital, Children s Memorial Research Center, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Allergy 66:1442-8. 2011
    ..However, the epidemiological evidence is conflicting. We aim to examine whether cord blood VDD is associated with FS and whether such association can be modified by genetic variants in a prospective birth cohort...
  101. doi IL-4 and MTHFR gene polymorphism in rheumatoid arthritis and their effects
    Ahmet Inanir
    Department of Physical Therapy and Rehabilitation, Faculty of Medicine, Gaziosmanpasa University, Tokat, 60100, Turkey
    Immunol Lett 152:104-8. 2013
    ..Our findings suggest that there is an association of IL-4 gene 70bp VNTR polymorphism and MTHFR C677T polymorphism with susceptibility of a person for development of RA. ..

Research Grants62

  1. Mouse models for the functional analysis of asthma-associated human polymorphisms
    Donata Vercelli; Fiscal Year: 2009
    ....
  2. Lisa M Coussens; Fiscal Year: 2015
    ....
  3. Jaroslaw Aronowski; Fiscal Year: 2016
    ....
  4. Jonathan Savitz; Fiscal Year: 2016
    ....
  5. Donata Vercelli; Fiscal Year: 2014
    ..Our studies will be the first to explore human Th2 cytokine regulation in vivo and will identify novel rational targets for effective treatments of allergic disease. ..
  6. A role for miRNAs in adenosine-dependent alternative macrophage activation
    Samuel Joseph Leibovich; Fiscal Year: 2013
    ..These studies should provide novel insights into differential gene regulation in macrophages under conditions that induce "M2d" activation. ..
  7. Involvement of Natural Killer T cells in Hepatic Fibrogenesis
    Ian N Hines; Fiscal Year: 2011
    ..Together, these studies will provide new insight into the mechanisms of T cell-mediated hepatic fibrosis. ..
  8. Early Environmental Hygiene and Pediatric Asthma
    Christine C Johnson; Fiscal Year: 2009
    ..If factors associated with animal or endotoxin contact are related to asthma risk, such factors would likely lend themselves to public health interventions. ..
  9. Mechanisms of Virus-Induced Hyperreactivity in Atopics
    David B Jacoby; Fiscal Year: 2010
    ..In the course of these experiments, substances released by lung cells that contribute to asthma will be identified, and ways to block them will be tested. This will assist us in developing new treatments for asthma. ..
  10. Paula C Bickford; Fiscal Year: 2016
    ..that underly changes in brain aging that make the brain more suceptible to disease is critical and can lead to new approacfies to reduce the incidence or severity of neurodegenerative diseases and declines in cognitive function with age..
  11. Immunobiology of MINA53
    Mark Bix; Fiscal Year: 2010
    ....
  12. BABAK MEHRARA MEHRARA; Fiscal Year: 2016
    ....
  13. Mouse models for the functional analysis of asthma-associated human polymorphisms
    Donata Vercelli; Fiscal Year: 2011
    ..abstract_text> ..
  14. Anjana Rao; Fiscal Year: 2014
    ..In this proposal we plan to investigate the role of TET proteins in T cells, a major class of cells in the immune system that protect the organism from attack by bacteria, viruses and other pathogens including cancer cells. ..
  15. Lactogenic immunity/probiotics: Effect on neonatal gut immunity
    Linda J Saif; Fiscal Year: 2010
    ..abstract_text> ..
  16. HIMF/FIZZ1/RELM-alpha activates macrophages in pulmonary hypertension
    Lucas Meuchel; Fiscal Year: 2013
    ..As such, we hope to more fully understand the initiating events in PH with the goal of translating these results to treatment and diagnosis of human pulmonary hypertension. ..
  17. Daniela Cihakova; Fiscal Year: 2015
    ....
  18. Biomarkers of survival in glioma epidemiology
    John K Wiencke; Fiscal Year: 2013
    ..abstract_text> ..
  19. Diet, Activity, and Lifestyle as a Risk Factor for Colorectal Cancer
    Martha L Slattery; Fiscal Year: 2012
    ..Identification of polymorphisms or haplotypes that are relevant to colorectal cancer will advance our understanding of etiology, may lead to specific health recommendations, and can identify targets for drug therapy. ..
  20. Cytokine Polymorphisms and Cancer Related Pain
    Cielito Reyes Gibby; Fiscal Year: 2009
    ..Understanding host genetic susceptibility to severe pain is critical to efforts in reducing the burden of cancer and its treatment. The results of this study have immense clinical and public health significance. ..
  21. Genotyping the NPF Biobank for Psoriasis Susceptibility Genes
    JAMES TILFORD ELDER; Fiscal Year: 2010
    ..Its cause is not well understood. Identification of genes that increase risk of psoriasis will help us unlock the secrets of this troubling disease, and identify targets for more specific and effective therapy. ..
  22. Pandurangan Vijayanand; Fiscal Year: 2015
    ..They will have a broad impact on our understanding of asthma, and set an important precedent for investigating the role of epigenetic mechanisms in other immune-mediated disorders. ) ..
  23. Barbara Fingleton; Fiscal Year: 2015
    ..Ultimately, this will lead to better therapy options for patients with metastatic colon cancer. ..
  24. Jonathan Cheetham; Fiscal Year: 2015
    ..This team will support me in this proposal and through my transition to independence. ..
  25. Genetic Risk Factors for Visceral Leishmaniasis
    Mary E Wilson; Fiscal Year: 2013
    ..The study could seed novel functional studies that could translate into future disease intervention measures. ..
  26. IL-4 AND RESISTANCE TO TOXOPLASMA GONDII
    Christopher Hunter; Fiscal Year: 2000
    ..The regulation of the immune system during a response to infection could lead to new therapeutic paradigms and/or approaches to treatment of many diseases as well as prove important in vaccine design. ..
  27. Gene Regulation by IL-4 and IL-13 in Airway Cells
    June Lee; Fiscal Year: 2004
    ..abstract_text> ..
  28. ENVIRONMENT AND EPIGENETIC CONTROL OF IMMUNE RESPONSES
    Mark Bix; Fiscal Year: 2004
    ..abstract_text> ..
  29. A Bifunctional Katp Channel Activator and Redox Mimetic for BPD
    Kanneganti Murthy; Fiscal Year: 2013
    ....
  30. 4PS MEDIATED SIGNALING PATHWAY IN IL4 SYSTEM
    Xiao Sun; Fiscal Year: 2000
    ....
  31. REGULATION OF IL4 PRODUCTION IN VIVO
    Fred Finkelman; Fiscal Year: 2002
    ..The results of these experiments will provide a better understanding of how IL-4 responses are regulated in vivo; this understanding will enhance the ability to control disorders that are regulated by IL-4. ..
  32. MOLECULAR MECHANISM OF IL4 SIGNALING
    Achsah Keegan; Fiscal Year: 2000
    ..Given the profound effects of IL-4 on immune regulation, an understanding of the mechanism of its actions could aid in the development of strategies to regulate immune responses elicited by vaccines or by environmental allergens. ..
  33. Regulation of IL4 signal transduciton by poly (ADP-ribose) polymerase-1.
    Rahul Datta; Fiscal Year: 2011
    ..Given the data demonstrating that PARP-1 inhibition abates of pulmonary inflammation in the mouse model of asthma, it is important to study the role of PARP-1 in inflammation in order to develop strategies in dealing with the disease. ..
  34. CHARACTERIZATION/MODULATION OF CYTOKINE RESPONSES IN FIV
    Gregg Dean; Fiscal Year: 2001
    ..Understanding the role of the cytokines in the pathogenesis, therapy, and vaccination in FIV infection will have direct implications for HIV infection. ..
  35. Type 1 Diabetes Mouse Resource (T1DR)
    David V Serreze; Fiscal Year: 2012
    ..The mission of the T1DR is to import, re-derive to a high-level health status, curate, genotypically and phenotypically validate, cryopreserve, and distribute mouse stocks of value to the T1D research community. ..
  36. Vaccination with IL-15 DC to Generate Melanoma-specific Protective Memory T Cells
    Anna Karolina Palucka; Fiscal Year: 2013
    ..Current therapies have the potential to improve outcome in a fraction of patients but are associated with considerable toxicity. Vaccination with melanoma antigen-loaded dendritic cells (DCs) could improve outcomes without toxicity. ..
  37. Cliona M Rooney; Fiscal Year: 2016
    ..This series of iterative laboratory and linked clinical studies is expected to yield strategies with the potential to increase cure rates and reduce treatment-related toxicity in patients with a spectrum of resistant solid tumors. ..
  38. Stanley H Appel; Fiscal Year: 2014
    ..These experiments will lead to the identification of the most effective human TLR2 siRNAs and treatment protocols which can be directly translated to ALS patients. ..
  39. MODEL SYSTEMS FOR DEVELOPMENT OF PAIN GENE THERAPY
    Joseph C Glorioso; Fiscal Year: 2010
    ..We believe this to be a timely and highly innovative proposal which is likely to provide new approaches to treatment of chronic pain related to diabetes and inflammation. ..
  40. Hua Huang; Fiscal Year: 2014
    ..PUBLIC HEALTH RELEVANCE: This proposal aims to study how a regulatory network, consisting of STAT5, GATA2 and C/EBP1, regulates novel basophil functions during allergic immune responses. ..
  41. Role of Mina53 in Effector CD4 T Cell Differentiation
    Mark Bix; Fiscal Year: 2010
    ..investigating: (1) how Mina53 regulates IL4 expression;(2) how Mina53 gene expression is regulated;(3) what are the relative contributions to Th2-bias of Mina53 activity in progenitor T helper cells and dendritic cells? ..
  42. INDUCTION OF IG C EPSILON & C GAMMA 1 BY IL4 & CD40L
    Janet Stavnezer; Fiscal Year: 2002
    ..We will determine if it is the differential arrangement and/or different binding proteins at the b-Zip element which regulates their different responses to IL-4 and B cell activators. ..
  43. PINWORM: A SELF TOLERANCE AND AUTOIMMUNE DISEASE MODIFIE
    Kenneth Tung; Fiscal Year: 2001
    ..In summary, with this hypothesis-driven proposal, we will explore a common and natural infectious agent and its capacity to terminate self tolerance and provoke autoimmune disease in neonatal mice. ..
  44. INDUCIBLE IL4 GENE TRANSCRIPTION IN T AND MAST CELLS
    Melissa Brown; Fiscal Year: 2004
    ..3. To identify other sequences that influence transcription of IL-4 and/or IL-13 in both T and mast cells. 4. To examine the molecular basis of strain-specific differences in murine IL-4 gene expression. ..
  45. LEISHMANIA INFECTION IN BALB/C IL4 NEG AND IL4R NEG MICE
    Nancy Noben Trauth; Fiscal Year: 2002
    ..major parasites and will offer alternative theories to the Th1/Th2 paradigm in general. These studies also will lead to new interpretations of the action of anti-IL-4 treatment in vivo. ..
  46. Prevention of airborne smallpox transmission
    Donald Milton; Fiscal Year: 2004
    ..abstract_text> ..
  47. ONTOGENY OF INTERFERON-GAMMA & INTERLEUKIN-4 PRODUCTION
    David Lewis; Fiscal Year: 1992
    ..This knowledge will allow a better assessment of the therapeutic potential of these proteins in treating the immunologically immature host...
  48. FUNCTION AND ACTIVATION OF HELPER T LYMPHOCYTES
    ABUL ABBAS; Fiscal Year: 1991
    ..The theme of the project is to define the biologic significance of the selective production of IL2 or BSF1 (IL4) by different T cell subsets...
  49. EXPRESSION OF GROWTH CONTROL GENES IN FUNCTIONAL T CELLS
    ELLEN ROTHENBERG; Fiscal Year: 1992
    ..In parallel, we will look directly for cell-type-specific regulatory proteins in gene transfer experiments with the murine IL2 gene in tissue culture cells and transgenic mice...
  50. COCKROACH ALLERGEN EXPOSURE IN CHILDHOOD ASTHMA
    Sampson Sarpong; Fiscal Year: 2002
    ..Cord blood will be analyzed for DNA, total IgE, lgA, Interleukin 4 (IL4) and Interferon (IFN) gamma...
  51. REGULATION OF IL4 IN CELLS INVOLVED IN ALLERGIC DISEASE
    Vincenzo Casolaro; Fiscal Year: 2001
    ..Defining the transcriptional factors that regulate the expression of the human ILA gene in Th cells and basophils may, in the long term, lead to novel therapeutic approaches for the treatment of allergic disorders. ..
  52. PRECLINICAL ANALYSIS OF DTH IN TRANSPLANT RECIPIENTS
    Anne Vanbuskirk; Fiscal Year: 2001
    ....
  53. INVARIANT T CELLS AND IL4 AND TYPE I DIABETES
    David Hafler; Fiscal Year: 2000
    ..The eventual goal of the project is to develop a therapy that can be administered to pre-diabetics that prevent their progression into diabetics. ..
  54. ALLOGRAFT-INDUCED IL4 IN PANCREAS GRAFT PROTECTION
    Joanna Davies; Fiscal Year: 2000
    ..We will use this information to manipulate the ratios of each cytokine in order to optimize the timing and dose of each cytokine with the ultimate goal of obtaining allograft protection. ..
  55. TRANSCRIPTIONAL REGULATION OF TH1/TH2 DIFFERENTIATION
    Thomas Aune; Fiscal Year: 2001
    Acquiring the ability to selectively produce interferon gamma (IFNgamma) or interleukin 4 (lL4) is a fundamental property of the immune system and enables T cell subsets (T helper 1, TH1, T helper 2, TH2) to deliver their effector ..
  56. MAST CELL SPECIFIC REGULATION OF IL4 GENE EXPRESSION
    Melissa Brown; Fiscal Year: 2000
    ..As it is possible that this novel transcript may represent an important mechanism for regulating IL-4 gene expression and for understanding the mechanisms behind its expression and by which it may regulate IL-4 biological activity. ..
  57. COSTIMULATORY MOLECULES, CTL, AND HIV IN LYMPHOID TISSUE
    Elizabeth Connick; Fiscal Year: 2002
    ....
  58. Genetic & epidemiologic cohort study of asthma & allergy
    Susan Ewart; Fiscal Year: 2009
    ..abstract_text> ..
  59. Lung epithelium-derived IL-6 in CD4+ T cell immune resp*
    Mercedes Rincon; Fiscal Year: 2004
    ..abstract_text> ..
  60. MECHANISMS OF ALLOGRAFT TOLERANCE
    Charles Orosz; Fiscal Year: 2002
    ..Finally, we will evaluate the effects of concurrent infection with murine influenza virus on he survival of the graft and recipient in mice that are being educated with BSA for allograft acceptance. ..
  61. EXPERIMENTAL AUTOIMMUNE GRAVES' DISEASE
    Bellur Prabhakar; Fiscal Year: 2003
    ..Such a model would facilitate a thorough understanding of the regulation of the immune response to TSHR with implications for the development of novel therapeutics. ..
  62. REGULATION OF THL RESPONSES IN PULMONARY SARCOIDOSIS
    DAVID MOLLER; Fiscal Year: 2000
    ..Thus, these studies may assist in the development of new therapies designed to halt the granulomatous and fibrotic responses that lead to end-stage pulmonary disease in sarcoidosis. ..