IL-1beta

Summary

Gene Symbol: IL-1beta
Description: interleukin 1 beta
Alias: IL-1, IL1-BETA, IL1F2, interleukin-1 beta, IL-1 beta, catabolin, preinterleukin 1 beta, pro-interleukin-1-beta
Species: human

Top Publications

  1. ncbi The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
    Fabio Martinon
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Mol Cell 10:417-26. 2002
  2. pmc ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1beta and IL-18 secretion in an autocrine way
    Alessandra Piccini
    Cell Biology Unit, National Cancer Research Institute, Largo Rosanna Benzi 10, 16132 Genoa, Italy
    Proc Natl Acad Sci U S A 105:8067-72. 2008
  3. doi Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis
    M Bryant Howren
    Department of Psychology, The University of Iowa, 11 Seashore Hall East, Iowa City, IA 52242, USA
    Psychosom Med 71:171-86. 2009
  4. pmc Altered redox state of monocytes from cryopyrin-associated periodic syndromes causes accelerated IL-1beta secretion
    Sara Tassi
    Cell Biology Unit, National Cancer Research Institute, 16132 Genoa, Italy
    Proc Natl Acad Sci U S A 107:9789-94. 2010
  5. ncbi Interleukin-1 polymorphisms associated with increased risk of gastric cancer
    E M El-Omar
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Nature 404:398-402. 2000
  6. ncbi Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study
    Joachim Spranger
    Department of Endocrinology, Diabetes and Nutrition, Benjamin Franklin Medical Center, Free University Berlin, Berlin, Germany
    Diabetes 52:812-7. 2003
  7. pmc Interleukin-1 in the genesis and progression of and risk for development of neuronal degeneration in Alzheimer's disease
    W Sue T Griffin
    Department of Geriatrics, Medicine, and Psychiatry, University of Arkansas for Medical Sciences, Veterans Affairs Medical Center, Little Rock, USA
    J Leukoc Biol 72:233-8. 2002
  8. ncbi Vascular endothelial growth factor is upregulated by interleukin-1 beta in human vascular smooth muscle cells via the P38 mitogen-activated protein kinase pathway
    Y D Jung
    Department of Cancer Biology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Angiogenesis 4:155-62. 2001
  9. pmc TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL
    Matthew C Walsh
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    PLoS ONE 3:e4064. 2008
  10. pmc Phospholipases C and A2 control lysosome-mediated IL-1 beta secretion: Implications for inflammatory processes
    Cristina Andrei
    Cell Transport Unit, Department of Oncogenesis, National Cancer Research Institute, 16132 Genoa, Italy
    Proc Natl Acad Sci U S A 101:9745-50. 2004

Research Grants

  1. ROLE OF MACROPHAGE SIALOPHORIN (CD43) IN HIV DEFENSE
    EILEEN REMOLD O DONNELL; Fiscal Year: 1992
  2. AIDS DEMENTIA--MOLECULAR AND CELLULAR MECHANISMS
    Floyd Bloom; Fiscal Year: 2000
  3. MOLECULAR BASIS FOR DRUG INDUCED CARDIOTOXICITY IN AIDS
    CRAIG CLARKSON; Fiscal Year: 2001
  4. A MACROPHAGE PROTEIN IN COLON TUMORIGENESIS
    Aniruddha Ganguly; Fiscal Year: 2001
  5. ACCESSORY CELL ACTIVATION OF THE IMMUNE RESPONSE
    PHILIP AURON; Fiscal Year: 2004
  6. Genetic susceptibility to gastric cancer in Latin America
    Eduardo M Tarazona-Santos; Fiscal Year: 2011
  7. Neural Plasticity and Inflammatory Pain
    Clifford J Woolf; Fiscal Year: 2010
  8. Emilio B Gonzalez; Fiscal Year: 2014
  9. Biobehavioral Genetics of CVD Risk
    Indrani Halder; Fiscal Year: 2010
  10. Alcohol, Glial Gene Expression and the Heat Shock Pathway
    Neil L Harrison; Fiscal Year: 2010

Detail Information

Publications345 found, 100 shown here

  1. ncbi The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
    Fabio Martinon
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Mol Cell 10:417-26. 2002
    ..Thus, the inflammasome constitutes an important arm of the innate immunity...
  2. pmc ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1beta and IL-18 secretion in an autocrine way
    Alessandra Piccini
    Cell Biology Unit, National Cancer Research Institute, Largo Rosanna Benzi 10, 16132 Genoa, Italy
    Proc Natl Acad Sci U S A 105:8067-72. 2008
    ..Thus, stimuli acting on different pathogen-sensing receptors converge on a common pathway where ATP externalization is the first step in the cascade of events leading to inflammasome activation and IL-1beta and IL-18 secretion...
  3. doi Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis
    M Bryant Howren
    Department of Psychology, The University of Iowa, 11 Seashore Hall East, Iowa City, IA 52242, USA
    Psychosom Med 71:171-86. 2009
    ..To assess the magnitude and direction of associations of depression with C-reactive protein (CRP), interleukin (IL)-1, and IL-6 in community and clinical samples...
  4. pmc Altered redox state of monocytes from cryopyrin-associated periodic syndromes causes accelerated IL-1beta secretion
    Sara Tassi
    Cell Biology Unit, National Cancer Research Institute, 16132 Genoa, Italy
    Proc Natl Acad Sci U S A 107:9789-94. 2010
    ....
  5. ncbi Interleukin-1 polymorphisms associated with increased risk of gastric cancer
    E M El-Omar
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Nature 404:398-402. 2000
    ..Host genetic factors that affect interleukin-1-beta may determine why some individuals infected with H. pylori develop gastric cancer while others do not...
  6. ncbi Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study
    Joachim Spranger
    Department of Endocrinology, Diabetes and Nutrition, Benjamin Franklin Medical Center, Free University Berlin, Berlin, Germany
    Diabetes 52:812-7. 2003
    ..These data strongly support the hypothesis that a subclinical inflammatory reaction has a role in the pathogenesis of type 2 diabetes...
  7. pmc Interleukin-1 in the genesis and progression of and risk for development of neuronal degeneration in Alzheimer's disease
    W Sue T Griffin
    Department of Geriatrics, Medicine, and Psychiatry, University of Arkansas for Medical Sciences, Veterans Affairs Medical Center, Little Rock, USA
    J Leukoc Biol 72:233-8. 2002
    ..Moreover, this increased risk is associated with earlier age of onset of the disease. Homozygosity for this polymorphism in combination with another in the IL-1B gene further increases risk...
  8. ncbi Vascular endothelial growth factor is upregulated by interleukin-1 beta in human vascular smooth muscle cells via the P38 mitogen-activated protein kinase pathway
    Y D Jung
    Department of Cancer Biology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Angiogenesis 4:155-62. 2001
    ..These data demonstrate that IL-1 beta may induce VEGF in hVSMCs, and suggest that this paracrine signaling pathway, may prevent, in part, apoptosis of ECs...
  9. pmc TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL
    Matthew C Walsh
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    PLoS ONE 3:e4064. 2008
    ..Collectively, our results suggest that while TRAF6 autoubiquitination may serve as a marker of activation, it is unlikely to underpin RING finger-dependent TRAF6 function...
  10. pmc Phospholipases C and A2 control lysosome-mediated IL-1 beta secretion: Implications for inflammatory processes
    Cristina Andrei
    Cell Transport Unit, Department of Oncogenesis, National Cancer Research Institute, 16132 Genoa, Italy
    Proc Natl Acad Sci U S A 101:9745-50. 2004
    ..This activation is ultimately responsible for lysosome exocytosis and IL-1 beta secretion...
  11. ncbi Pattern of interleukin-1beta secretion in response to lipopolysaccharide and ATP before and after interleukin-1 blockade in patients with CIAS1 mutations
    Marco Gattorno
    Second Division of Pediatrics, IRCCS, Istituto G Gaslini, Genoa, Italy
    Arthritis Rheum 56:3138-48. 2007
    ....
  12. doi Gene polymorphisms in the NALP3 inflammasome are associated with interleukin-1 production and severe inflammation: relation to common inflammatory diseases?
    Deepti Verma
    Linkoping University, Linkoping, Sweden
    Arthritis Rheum 58:888-94. 2008
    ..We undertook this study to determine whether a patient with arthritis and antibiotic-resistant fever carried mutations in the genes encoding the NALP3 inflammasome...
  13. pmc Convergence of IL-1beta and VDR activation pathways in human TLR2/1-induced antimicrobial responses
    Philip T Liu
    Division of Dermatology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 4:e5810. 2009
    ..Therefore, these data identify a novel mechanism of host defense requiring the induction of IL-1beta in synergy with vitamin D activation, for the TLR-induced antimicrobial pathway against an intracellular pathogen...
  14. doi Role of IL-1beta in type 2 diabetes
    Charles A Dinarello
    Department of Medicine, University of Colorado, Aurora, Colorado 80045, USA
    Curr Opin Endocrinol Diabetes Obes 17:314-21. 2010
    ..To understand the role of inflammation as the fundamental cause of type 2 diabetes and specifically to examine the contribution of IL-1beta...
  15. ncbi Differential binding of proteins to the IL1B -31 T/C polymorphism in lung epithelial cells
    Helge Lind
    Section for Toxicology, Department of Chemical and Biological Working Environment, National Institute of Occupational Health, Oslo, Norway
    Cytokine 38:43-8. 2007
    ..Due to the high frequency of this SNP, differences in IL1B gene expression caused by the variants may have significant biological impact in the population...
  16. ncbi Proinflammatory cytokine single nucleotide polymorphisms in nasal polyposis
    Selim S Erbek
    Department of Otolaryngology, Faculty of Medicine, Baskent University Konya Teaching and Research Center, Saray Caddesi No 1, Selcuklu Konya, Ankara, Turkey
    Arch Otolaryngol Head Neck Surg 133:705-9. 2007
    ....
  17. ncbi A functional interleukin-1 receptor antagonist polymorphism influences atherosclerosis development. The interleukin-1beta:interleukin-1 receptor antagonist balance in atherosclerosis
    Peder S Olofsson
    Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Circ J 73:1531-6. 2009
    ..Knowledge of protein levels in atherosclerosis and the influence of a functional IL-1Ra polymorphism would increase the understanding of atherosclerosis pathogenesis...
  18. pmc Distinct roles for Nod2 protein and autocrine interleukin-1beta in muramyl dipeptide-induced mitogen-activated protein kinase activation and cytokine secretion in human macrophages
    Matija Hedl
    Department of Internal Medicine, Yale University, New Haven, Connecticut 06510, USA
    J Biol Chem 286:26440-9. 2011
    ..Our findings clarify mechanisms of IL-1β contributions to Nod2 responses and elucidate the dominant role of IL-1β in MDP-initiated MAPK and cytokine secretion...
  19. ncbi Interleukin-1beta induces MUC2 and MUC5AC synthesis through cyclooxygenase-2 in NCI-H292 cells
    Yong Dae Kim
    Department of Otorhinolaryngology, College of Medicine, Yeungnam University, Nam Gu, Daegu, South Korea
    Mol Pharmacol 62:1112-8. 2002
    ..These results indicate that in human pulmonary epithelial cells, IL-1beta activates ERK or p38 to induce COX-2 production, which in turn induces MUC2 and MUC5AC production...
  20. doi Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription
    Bo Wang
    Centre for Vascular Research, University of New South Wales, Sydney NSW 2052, Australia
    Arterioscler Thromb Vasc Biol 30:536-45. 2010
    ..EGR-1 autoregulation, and histone modification in the EGR-1 promoter, represent key mechanisms in EGR-1 control, but have not been explored...
  21. doi Interleukin-1 receptor phosphorylation activates Rho kinase to disrupt human gastric tight junctional claudin-4 during Helicobacter pylori infection
    Tamia K Lapointe
    Department of Biological Sciences and Inflammation Research Network, University of Calgary, Alberta, Canada
    Cell Microbiol 12:692-703. 2010
    ..pylori disrupts gastric epithelial barrier structure via IL-1RI-dependent activation of ROCK, which in turn mediates tight junctional claudin-4 disruption...
  22. pmc Varicella-zoster virus infection triggers formation of an interleukin-1β (IL-1β)-processing inflammasome complex
    Adel M Nour
    Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 286:17921-33. 2011
    ..We conclude that NLRP3 inflammasome formation is an innate cellular response to infection with this common pathogenic human herpesvirus...
  23. pmc RNA-binding protein HuR interacts with thrombomodulin 5'untranslated region and represses internal ribosome entry site-mediated translation under IL-1 beta treatment
    Chiu Hung Yeh
    Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
    Mol Biol Cell 19:3812-22. 2008
    ..In summary, HuR plays an important role in suppression of TM protein synthesis in IL-1beta treatment and sepsis...
  24. ncbi Interleukin 1B and interleukin 1RN polymorphisms are associated with increased risk of gastric carcinoma
    J C Machado
    Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal
    Gastroenterology 121:823-9. 2001
    ....
  25. pmc The rate of interleukin-1beta secretion in different myeloid cells varies with the extent of redox response to Toll-like receptor triggering
    Sonia Carta
    Cell Biology Unit, National Cancer Research Institute, 16132 Genova, Italy
    J Biol Chem 286:27069-80. 2011
    ..Inflammasome activation by bacterial DNA is not modulated by redox responses, suggesting that redox-dependent regulation of IL-1β secretion is restricted to some inflammasomes including NLRP3 but excluding AIM-2...
  26. pmc Binding of human immunodeficiency virus type 1 to CD4 and CXCR4 receptors differentially regulates expression of inflammatory genes and activates the MEK/ERK signaling pathway
    W Popik
    Oncology Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    J Virol 72:6406-13. 1998
    ....
  27. ncbi Heat shock factor 1 represses transcription of the IL-1beta gene through physical interaction with the nuclear factor of interleukin 6
    Yue Xie
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Beth Israel and Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:11802-10. 2002
    ..Interaction between HSF1 and NF-IL6 could thus be an important mechanism in HSF1 regulation of general gene transcription during endotoxin stress...
  28. ncbi Interleukins-1, -4, -6, -10, tumor necrosis factor, transforming growth factor-beta, FAS, and mannose-binding protein C gene polymorphisms in Australian women: Risk of preterm birth
    Margaret F Annells
    Department of Microbiology and Infectious Diseases, Women s and Children s Hospital, North Adelaide, South Australia
    Am J Obstet Gynecol 191:2056-67. 2004
    ..The purpose of this study was to examine the relationship between preterm birth and 22 single nucleotide polymorphisms in genes that encode cytokines and mediators of apoptosis and host defense...
  29. pmc Constitutively active inflammasome in human melanoma cells mediating autoinflammation via caspase-1 processing and secretion of interleukin-1beta
    Miyako Okamoto
    Department of Dermatology, University of Colorado Denver, Aurora, Colorado 80045, USA
    J Biol Chem 285:6477-88. 2010
    ....
  30. doi Polymorphisms in genes involved in the inflammatory response and interaction with NSAID use or smoking in relation to lung cancer risk in a prospective study
    Ulla Vogel
    National Research Centre for the Working Environment, DK 2100 Copenhagen O, Denmark
    Mutat Res 639:89-100. 2008
    ..p for interaction was 3 x 10(-6) for COX-2 A-1195G and 9 x 10(-5) for PPARgamma2 Pro(12)Ala. The results suggest that NSAID use may modify risk of lung cancer differently depending on the genotype...
  31. pmc Stimulation of Toll-like receptor 3 and 4 induces interleukin-1beta maturation by caspase-8
    Jonathan Maelfait
    Unit of Molecular Signal Transduction in Inflammation, Department for Molecular Biomedical Research, VIB, B 9052 Ghent, Belgium
    J Exp Med 205:1967-73. 2008
    ..These results implicate a novel role for caspase-8 in the production of biologically active IL-1beta in response to TLR3 and TLR4 stimulation...
  32. ncbi Involvement of interleukin-1 genotypes in the association of coronary heart disease with periodontitis
    Karen Geismar
    Department of Periodontology, Dental School, University of Copenhagen, Copenhagen, Denmark
    J Periodontol 79:2322-30. 2008
    ..The coexistence of the two disease entities could be dependent on mutual risk factors, and polymorphism of the interleukin (IL)-1 gene cluster associated with the severity of PE might also be involved in the pathogenesis of CHD...
  33. ncbi Analysis of IL1B, TAP1, TAP2 and IKBL polymorphisms on susceptibility to tuberculosis
    L M Gomez
    Cellular Biology and Immunogenetics Unit, Corporacion para Investigaciones Biologicas, CIB, Medellin, Colombia
    Tissue Antigens 67:290-6. 2006
    ..These results indicate that a functional polymorphism in the IL1B gene influences the susceptibility to TB and suggest a role for IL-1beta in the pathogenesis of mycobacterial infection...
  34. ncbi The concomitant presence of polymorphic alleles of interleukin-1beta, interleukin-6 and apolipoprotein E is associated with an increased risk of myocardial infarction in elderly men. Results from a pilot study
    Federico Licastro
    Department of Experimental Pathology, Via S Giacomo 14, 40126 Bologna, Italy
    Mech Ageing Dev 125:575-9. 2004
    ..The administration of anti-inflammatory compounds to middle age healthy subjects with increased genetic susceptibility of developing MI might decrease the incidence and prevalence of cardiovascular events in aging...
  35. ncbi Association of interleukin-1B (IL-1B) gene polymorphisms with risk of gastric cancer in Chinese population
    Wei hua Zhang
    School of Life Science, Lanzhou University, Lanzhou, Gansu, China Department of Gastroenterology, The Gansu Provincial Cancer Hospital, Lanzhou, Gansu, China
    Cytokine 30:378-81. 2005
    ..The results of this study did not support the report that IL-1RN*2+ genotypes were associated with increased risk of GC in Chinese population...
  36. doi The role of the composite interleukin-1 genotype in the association between periodontitis and acute myocardial infarction
    Jamal M Stein
    Department of Operative Dentistry and Periodontology, University Hospital Aachen, Aachen, Germany
    J Periodontol 80:1095-102. 2009
    ..The aim of this study was to evaluate the impact of the composite IL-1 genotype (allele 2 at IL-1A -889 and IL-1B +3954) in the association between acute myocardial infarction (AMI) and periodontitis...
  37. doi Interleukin-1 beta and interleukin-6 gene polymorphism associations with angiographically assessed coronary artery disease in Brazilians
    Domingos L S Rios
    Departamento de Ciências da Vida, Universidade do Estado da Bahia UNEB, Campus I, Rua SilveiraMartins, n 2555, ZIP code 41 195 001, Salvador, BA, Brazil
    Cytokine 50:292-6. 2010
    ..This report shows that the IL-1B-511C>T and IL-6-174G>C polymorphisms were associated with CAD risk in African-Brazilians and no association was detected among Caucasian-Brazilians...
  38. pmc Cortical cell death induced by IL-1 is mediated via actions in the hypothalamus of the rat
    S M Allan
    School of Biological Sciences, 1 124 Stopford Building, University of Manchester, Oxford Road, Manchester, M13 9PT, United Kingdom
    Proc Natl Acad Sci U S A 97:5580-5. 2000
    ....
  39. ncbi Variation within genes encoding interleukin-1 and the interleukin-1 receptor antagonist influence the severity of meningococcal disease
    Robert C Read
    Division of Genomic Medicine, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX, United Kingdom
    Ann Intern Med 138:534-41. 2003
    ..Genetically determined variation in proinflammatory cytokine release influences severity of meningococcal disease and other serious infections...
  40. ncbi HIV-1 gp120 stimulates proinflammatory cytokine-mediated pain facilitation via activation of nitric oxide synthase-I (nNOS)
    Adelina Holguin
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309, USA
    Pain 110:517-30. 2004
    ..Furthermore, gp120 increases mRNA for IL1 converting enzyme and matrix metalloproteinase-9, enzymes responsible for activation and release of proinflammatory cytokines...
  41. ncbi Extracellular human thioredoxin-1 inhibits lipopolysaccharide-induced interleukin-1beta expression in human monocyte-derived macrophages
    Ludivine Billiet
    U 545 INSERM, Institut Pasteur de Lille and Université Lille 2, 59019 Lille, France
    J Biol Chem 280:40310-8. 2005
    ..Taken together, these data indicated a potential new mechanism through which extracellular rhTrx-1 exerts an anti-inflammatory function in HMDM...
  42. doi Alterations of the CD4(+), CD8 (+) T cell subsets, interleukins-1beta, IL-10, IL-17, tumor necrosis factor-alpha and soluble intercellular adhesion molecule-1 in rheumatoid arthritis and osteoarthritis: preliminary observations
    Mahmoud R Hussein
    Pathology Department, Faculty of Medicine, Assuit University and Assir Central Hospitals, Assuit, Egypt
    Pathol Oncol Res 14:321-8. 2008
    ..To conclude, the development of rheumatoid arthritis and osteoarthritis is associated with alteration of the levels of some cytokines. The assessment of these immunologic changes may have potential prognostic roles...
  43. doi IL1 gene cluster polymorphisms and its haplotypes may predict the risk to develop invasive pulmonary aspergillosis and modulate C-reactive protein level
    J Sainz
    Unidad de Investigacion, Hospital Universitario Virgen de las Nieves, Granada, Spain
    J Clin Immunol 28:473-85. 2008
    ..The aim of this study was to determine whether interleukin-1 alpha (IL1alpha), interleukin-1 beta (IL1beta), and IL1 receptor antagonist (IL1Ra) polymorphisms are implicated in invasive pulmonary aspergillosis (IPA) pathogenesis...
  44. pmc Interleukin (IL) 1beta induction of IL-6 is mediated by a novel phosphatidylinositol 3-kinase-dependent AKT/IkappaB kinase alpha pathway targeting activator protein-1
    Catherine M Cahill
    Neurochemistry Laboratory, Department of Psychiatry Neuroscience and Genetics and Aging Research Unit, Massachusetts General Hospital East, Charlestown, Massachusetts 02129, USA
    J Biol Chem 283:25900-12. 2008
    ..This novel pathway is a parallel pathway to the PI 3-kinase/AKT upstream of NFkappaB and both are involved in IL-6 gene transcription in response to IL-1...
  45. pmc Regulation of epithelial-mesenchymal IL-1 signaling by PPARbeta/delta is essential for skin homeostasis and wound healing
    Han Chung Chong
    School of Biological Sciences, Nanyang Technological University, Singapore 637551
    J Cell Biol 184:817-31. 2009
    ..Given the ubiquitous expression of PPARbeta/delta, other epithelial-mesenchymal interactions may also be regulated in a similar manner...
  46. doi Graves' ophthalmopathy and gene polymorphisms in interleukin-1alpha, interleukin-1beta, interleukin-1 receptor and interleukin-1 receptor antagonist
    Omid Khalilzadeh
    Endocrinology and Metabolism Research Center, Vali Asr Hospital, Tehran, Iran
    Clin Exp Ophthalmol 37:614-9. 2009
    ..This study aimed to investigate the association of GO with single-nucleotide polymorphisms (SNPs) in the IL-1 family (IL-1alpha, IL-1beta, IL-1 receptor [IL-1R] and IL-1 receptor antagonist [IL-1RA])...
  47. pmc Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation
    Yihui Fan
    Laboratory of Medical Genetics, Harbin Medical University, Harbin 150081, China
    J Biol Chem 285:5347-60. 2010
    ....
  48. doi Tyrosine hydroxylase, interleukin-1beta and tumor necrosis factor-alpha are overexpressed in peripheral blood mononuclear cells from schizophrenia patients as determined by semi-quantitative analysis
    Liang Liu
    Wuxi Mental Health Center, Nanjing Medical University, Wuxi, China
    Psychiatry Res 176:1-7. 2010
    ..IL-1beta and TNF-alpha may influence the symptoms of schizophrenia in the cognition dysfunction and anxiety/depression domains of the PANSS...
  49. pmc Regulation of interleukin-1beta by interferon-gamma is species specific, limited by suppressor of cytokine signalling 1 and influences interleukin-17 production
    Seth L Masters
    Immunology Research Centre, School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    EMBO Rep 11:640-6. 2010
    ..In mice, IFNgamma decreased IL-1beta and subsequently IL-17, indicating that the adaptive immune response can provide a systemic, but transient, signal to limit inflammation...
  50. doi Interleukin-1B and interleukin-1 receptor antagonist gene polymorphisms are not associated with premalignant gastric conditions: a combined haplotype analysis
    Limas Kupcinskas
    Department of Gastroenterology, Kaunas University of Medicine, Kaunas, Lithuania
    Eur J Gastroenterol Hepatol 22:1189-95. 2010
    ..Here, IL1B and IL1RN polymorphisms were analyzed as genotypes and haplotypes in relation to the presence of atrophic gastritis (AG) and intestinal metaplasia in the stomach...
  51. doi Ras regulates interleukin-1β-induced HIF-1α transcriptional activity in glioblastoma
    Vivek Sharma
    National Brain Research Centre, Manesar, Haryana, 122 050, India
    J Mol Med (Berl) 89:123-36. 2011
    ....
  52. pmc IL-1beta-induced increase in intestinal epithelial tight junction permeability is mediated by MEKK-1 activation of canonical NF-kappaB pathway
    Rana Al-Sadi
    Department of Internal Medicine, MSC10 5550, University of New Mexico School of Medicine, Albuquerque Veterans Affairs Medical Center, Albuquerque, NM 87131 0001, USA
    Am J Pathol 177:2310-22. 2010
    ..In conclusion, our data show for the first time that MEKK-1 plays an integral role in IL-1β modulation of Caco-2 TJ barrier function by regulating the activation of the canonical NF-κB pathway and the MLCK gene...
  53. pmc Expression of lumican and fibromodulin following interleukin-1 beta stimulation of disc cells of the human temporomandibular joint
    N Kiga
    Department of Oral and Maxillofacial Surgery, Wakayama Medical University, Japan
    Eur J Histochem 55:e11. 2011
    ..05). These results indicate that lumican and fibromodulin display different behaviors and that lumican may promote regeneration of the TMJ after degeneration and deformation induced by IL-1 β...
  54. ncbi Role of the pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6 and interleukin-8 in the pathogenesis of the otitis media with effusion
    Marina G Smirnova
    Department of Physiological Sciences, University of Newcastle, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Eur Cytokine Netw 13:161-72. 2002
    ..In this article, we aim to present an overview of current research developments in the pro-inflammatory cytokine involvement in the aetiology of otitis media with effusion...
  55. ncbi Polymorphisms in interleukin-1beta and interleukin-1 receptor antagonist genes and malaria in Ghanaian children
    B Gyan
    Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana
    Scand J Immunol 56:619-22. 2002
    ..01). The mean parasitaemia in an age-matched asymptomatic group did not reveal such associations. These data suggest that IL-1beta exon 5 allele 2 may play a possible role in the clinical outcome of uncomplicated malaria...
  56. doi Cytokine Genes TNF, IL1A, IL1B, IL6, IL1RN and IL10, and childhood-onset mood disorders
    V L Misener
    Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Neuropsychobiology 58:71-80. 2008
    ..Here, we have tested 6 key genes of this type, TNF, IL1A, IL1B, IL6, IL1RN and IL10, as candidates for involvement in childhood-onset mood disorders...
  57. pmc Modic changes and interleukin 1 gene locus polymorphisms in occupational cohort of middle-aged men
    Jaro Karppinen
    Finnish Institute of Occupational Health, Helsinki, Finland
    Eur Spine J 18:1963-70. 2009
    ..This observation is in accordance with the previous finding from a different geographical area, and thus confirms the importance of the IL1A gene in the pathophysiology of Modic changes...
  58. pmc Rab39a binds caspase-1 and is required for caspase-1-dependent interleukin-1beta secretion
    Christine E Becker
    School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    J Biol Chem 284:34531-7. 2009
    ..Altogether, our findings show that Rab39a interacts with caspase-1 and suggest that Rab39a functions as a trafficking adaptor linking caspase-1 to IL-1beta secretion...
  59. doi The interleukin 1 beta (IL1B) gene is associated with failure to achieve remission and impaired emotion processing in major depression
    Bernhard T Baune
    Department of Psychiatry and Psychiatric Neuroscience, James Cook University, Queensland, Australia
    Biol Psychiatry 67:543-9. 2010
    ..This study investigated the association between genetic variants of the interleukin 1 beta (IL1B) gene and amygdala and ACC responsiveness to emotional stimuli and response to antidepressant treatment...
  60. doi Three polymorphisms in interleukin-1β gene and risk for breast cancer: a meta-analysis
    Xiaoan Liu
    Department of Breast Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China
    Breast Cancer Res Treat 124:821-5. 2010
    ..49 for heterogeneity). For rs16944 (C > T) and rs1143634 (C > T), no significant associations were found in all genetic models. In conclusion, the present meta-analysis suggests that rs1143627 is associated with breast cancer risk...
  61. ncbi Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2
    R Debets
    DNAX Research Institute of Molecular and Cellular Biology, 901 California Avenue, Palo Alto, CA 94304, USA
    J Immunol 167:1440-6. 2001
    ....
  62. ncbi Interleukin-1 gene cluster polymorphisms in sarcoidosis and idiopathic pulmonary fibrosis
    Beata Hutyrova
    Departments of Immunology, Biology, and Respiratory Medicine, Palacky University, Olomouc, Czech Republic
    Am J Respir Crit Care Med 165:148-51. 2002
    ..Further population studies are warranted to confirm the observed association between sarcoidosis and the IL-1alpha polymorphism and also to explore mechanisms of IL-1alpha -889 participation in aberrant immune response in sarcoidosis...
  63. pmc De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases
    Ivona Aksentijevich
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892, USA
    Arthritis Rheum 46:3340-8. 2002
    ....
  64. ncbi Interleukin-1 gene polymorphisms and gastric cancer risk in a high-risk Italian population
    D Palli
    Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Center CSPO, Scientific Institute of Tuscany, Florence, Italy
    Am J Gastroenterol 100:1941-8. 2005
    ..The aim of the study was to investigate the relationship between selected IL1 loci polymorphisms and gastric cancer risk in an Italian population...
  65. ncbi Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain
    L Deng
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas 75390, USA
    Cell 103:351-61. 2000
    ..These results unveil a new regulatory function for ubiquitin, in which IKK is activated through the assembly of K63-linked polyubiquitin chains...
  66. ncbi Secretion of interleukin-1beta by astrocytes mediates endothelin-1 and tumour necrosis factor-alpha effects on human brain microvascular endothelial cell permeability
    Nathalie Didier
    Commissariat a l Energie Atomique CEA, Service de Pharmacologie et d Immunologie, Saclay, France
    J Neurochem 86:246-54. 2003
    ..Taken together, these results provide evidence for paracrine actions involving ET-1, TNF-alpha and IL-1beta between human astrocytes and BMVECs, which may play a central role in BBB breakdown during CNS inflammation...
  67. ncbi Immunomodulatory effects of probiotic bacteria DNA: IL-1 and IL-10 response in human peripheral blood mononuclear cells
    Karen Manon Lammers
    Department of Internal Medicine and Gastroenterology, University of Bologna, Policlinic S Orsola, Via Massarenti 9, 40138 Bologna, Italy
    FEMS Immunol Med Microbiol 38:165-72. 2003
    ..Total bacterial DNA from feces collected after probiotic administration modulated the immune response by a decrease of interleukin-1 beta and an increase of interleukin-10...
  68. ncbi Polymorphisms of the interleukin-1beta gene affect the risk of myocardial infarction and ischemic stroke at young age and the response of mononuclear cells to stimulation in vitro
    L Iacoviello
    Center for High Technology Research and Education in Biomedical Sciences, Catholic University, Campobasso, Italy
    Arterioscler Thromb Vasc Biol 25:222-7. 2005
    ..To investigate the role of interleukin-1beta (IL-1beta) gene polymorphisms as a link between inflammation, coagulation, and risk of ischemic vascular disease at young age...
  69. ncbi Topological frustration and the folding of interleukin-1 beta
    Shachi Gosavi
    Center for Theoretical Biological Physics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92037, USA
    J Mol Biol 357:986-96. 2006
    ..Complex folds like the beta-trefoil fold and functional loops like the beta-bulge of IL-1beta can make some of the configuration space unavailable to the protein and cause topological frustration...
  70. pmc Dose-dependent cross-talk between the transforming growth factor-beta and interleukin-1 signaling pathways
    Tao Lu
    Department of Molecular Genetics, Lerner Research Institute, and Brain Tumor Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Proc Natl Acad Sci U S A 104:4365-70. 2007
    ....
  71. ncbi A new nomenclature for IL-1-family genes
    J E Sims
    Trends Immunol 22:536-7. 2001
  72. pmc Allelic variation at the interleukin 1beta gene is associated with decreased bone mass in patients with inflammatory bowel diseases
    A Nemetz
    2nd Department of Medicine, Semmelweis University, Budapest, Hungary
    Gut 49:644-9. 2001
    ..Both cytokines influence bone formation. IL-1beta stimulates osteoclast activity while interleukin 1 receptor antagonist (IL-1ra) enhances bone formation...
  73. ncbi Genetic differences in interleukin-1 betapolymorphisms among four Asian populations: an analysis of the Asian paradox between H. pylori infection and gastric cancer incidence
    N Matsukura
    First Dept of Surgery, Nippon Medical School, Tokyo, Japan
    J Exp Clin Cancer Res 22:47-55. 2003
    ..IL-1betapolymorphisms were correlated with mucosal atrophy in the Japanese and Chinese populations, but not in the Thai and Vietnamese populations...
  74. ncbi A proinflammatory genetic profile increases the risk for chronic atrophic gastritis and gastric carcinoma
    Jose Carlos Machado
    Institute of Molecular Pathology and Immunology of the University of Porto, Rua Dr Roberto Frias, S N, 4200 465 Porto, Portugal
    Gastroenterology 125:364-71. 2003
    ..We also investigated the extent to which the combined effect of proinflammatory genetic polymorphisms (IL-1B, IL-1RN, and TNF-alpha), and the combined effect of TNF-alpha and bacterial genotypes each influence such a risk...
  75. ncbi HIV-1 and IL-1 beta regulate Fas ligand expression in human astrocytes through the NF-kappa B pathway
    A Ghorpade
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 5215, USA
    J Neuroimmunol 141:141-9. 2003
    ..001) and seronegative individuals (p<0.01). We propose that astrocyte expression of FasL may participate in neuronal injury in HAD...
  76. ncbi The role of cytokine gene polymorphisms in colorectal cancer and their interaction with aspirin use in the northeast of Scotland
    Mairi Macarthur
    Department of Medicine and Therapeutics, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
    Cancer Epidemiol Biomarkers Prev 14:1613-8. 2005
    ..These results suggest that host genetics may play a role in predicting response to chemopreventive strategies. Confirmation of these findings in other populations is required...
  77. ncbi Interleukin-1beta and interleukin-1 receptor antagonist gene polymorphisms and gastric cancer: a meta-analysis
    M Constanza Camargo
    Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center, 2215 Garland Avenue, 1005 MRB IV, Nashville, TN 37232 0252, USA
    Cancer Epidemiol Biomarkers Prev 15:1674-87. 2006
    ..Polymorphisms of interleukin-1B (IL1B) and its receptor antagonist (IL1RN) genes have been inconsistently associated with gastric cancer risk. We examined these associations by performing meta-analyses...
  78. pmc High mobility group box 1 potentiates the pro-inflammatory effects of interleukin-1β in osteoarthritic synoviocytes
    Isabel García-Arnandis
    Department of Pharmacology, University of Valencia, Valencia, Spain
    Arthritis Res Ther 12:R165. 2010
    ..We have recently reported that HMGB1 is released by osteoarthritic synoviocytes after activation with interleukin-1beta (IL-1β) The present study investigated the role of HMGB1 in synovial inflammation in osteoarthritis (OA)...
  79. doi Association between interleukin 1 polymorphisms and rheumatoid arthritis susceptibility: a metaanalysis
    Young Ho Lee
    Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126 1 ga, Anam Dong, Seongbuk gu, Seoul, 136 705, Korea
    J Rheumatol 36:12-5. 2009
    ..To determine whether interleukin 1 (IL-1) polymorphisms confer susceptibility to rheumatoid arthritis (RA)...
  80. pmc Interleukin (IL)-1 promotes allogeneic T cell intimal infiltration and IL-17 production in a model of human artery rejection
    Deepak A Rao
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    J Exp Med 205:3145-58. 2008
    ....
  81. ncbi Chylomicron remnants stimulate release of interleukin-1beta by THP-1 cells
    Takahiro Okumura
    Department of Internal Medicine, Division of Coronary Heart Disease, Hyogo College of Medicine, Nishinomiya, Japan
    J Atheroscler Thromb 13:38-45. 2006
    ..In conclusion, chylomicron remnants stimulated IL-1beta mRNA expression and IL-1beta protein production probably via caspase-1 and NF-kappaB activation in THP-1 cells...
  82. ncbi A high interleukin 1 receptor antagonist/IL-1beta ratio occurs naturally in knee osteoarthritis
    Pascal Richette
    Universite Paris 7, UFR médicale, Assistance Publique Hopitaux de Paris, Paris, France
    J Rheumatol 35:1650-4. 2008
    ....
  83. doi IL1B promoter polymorphism regulates the expression of gastric acid stimulating hormone gastrin
    Meenakshi Chakravorty
    Molecular and Human Genetics Division, Indian Institute of Chemical Biology, Raja S C Mullick Road, Kolkata, India
    Int J Biochem Cell Biol 41:1502-10. 2009
    ..Thus, this study showed that a single base substitution at the -31 position of the IL1B promoter brought about differential expression of IL1B which differentially altered both NFkappaB activation and gastrin expression...
  84. doi Clinical relevance of IL-1beta promoter polymorphisms (-1470, -511, and -31) in patients with major trauma
    Ai qing Wen
    State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, P R China
    Shock 33:576-82. 2010
    ..It may be possible to use these polymorphisms as relevant risk estimates for sepsis in trauma patients...
  85. doi TNF-alpha, IL-6, and IL-1 expression is inhibited by GAS6 in monocytes/macrophages
    Federica Alciato
    Clinical Immunology, Department of Clinical and Experimental Medicine, Universita del Piemonte Orientale A Avogadro, Novara, Italy
    J Leukoc Biol 87:869-75. 2010
    ..Therefore, GAS6 modulates macrophage cytokine secretion, triggering an "anti-inflammatory pathway" involving PI3K/Akt/GSK3 beta and NF-kappaB...
  86. ncbi Lack of association between pro-inflammatory genotypes of the interleukin-1 (IL-1B -31 C/+ and IL-1RN *2/*2) and gastric cancer/duodenal ulcer in Korean population
    Seong Gene Lee
    Asan Institute for Life Sciences, University of Ulsan College of Medicine, 388 1 Poongnap dong, Songpa Gu, Seoul 138 736, South Korea
    Cytokine 21:167-71. 2003
    ..The lack of association with duodenal ulcer also suggested that the polymorphisms were not directly related to the acid-secreting capability...
  87. ncbi In-vitro secretion of proinflammatory cytokines by human amniochorion carrying hyper-responsive gene polymorphisms of tumour necrosis factor-alpha and interleukin-1beta
    C Hernandez-Guerrero
    Department of Ultrastructure, Instituto Nacional de Perinatologia, Lomas de Virreyes, Mexico City, Mexico
    Mol Hum Reprod 9:625-9. 2003
    ....
  88. ncbi Novel interleukin 1beta polymorphism increased the risk of gastric cancer in a Korean population
    Kyung A Lee
    Department of Clinical Pathology, Samsung Medical Center, Sungkyunkwan University, School of Medicine, 50 Ilwon Dong, Kangnam Ku, Seoul 135 710, South Korea
    J Gastroenterol 39:429-33. 2004
    ..Therefore, we assessed an additional polymorphism in the promoter region of IL-1B at position-1473 with the IL-1B-511/-31 polymorphisms in a Korean population...
  89. ncbi Polymorphisms in inflammation-related genes and risk of gastric cancer (Finland)
    Farin Kamangar
    Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD 20892 7232, USA
    Cancer Causes Control 17:117-25. 2006
    ..Our results do not support the hypothesis that polymorphisms in genes involved in the inflammatory response confer differences in gastric cancer risk among different individuals...
  90. ncbi Genetic variation in pro-inflammatory cytokines (interleukin-1beta, interleukin-1alpha and interleukin-6) associated with the aggressive forms, survival, and relapse prediction of breast carcinoma
    Kaouther Snoussi
    Laboratoire d Immuno Oncologie Moleculaire, Faculte de medecine de Monastir, Universite de Monastir, 5019 Monastir, Tunisia
    Eur Cytokine Netw 16:253-60. 2005
    ..We designed a broad study to investigate the susceptibility and prognostic implications of the genetic variation in IL-1alpha, IL-1beta and IL-6 in breast carcinoma...
  91. pmc Interleukin-1 modulation of human placental trophoblast proliferation
    Athip Nilkaeo
    Department of Microbiology, Faculty of Science, Prince of Songkla University, Hat Yai, Songkla 90112, Thailand
    Mediators Inflamm 2006:79359. 2006
    ..These findings demonstrated that IL-1 regulates human trophoblast growth by induction of cell cycle delay and cell death...
  92. doi Interleukin-1B (-511) gene polymorphism is associated with acute coronary syndrome in the Turkish population
    Ozer Soylu
    The Department of Cardiology, Dr Siyami Ersek Hospital, Istanbul, Turkey
    Eur Cytokine Netw 19:42-8. 2008
    ..The purpose of this study was to determine the relationship between IL-1 gene family polymorphisms (IL-1RN, IL-1B in positions -511 and +3953) and ACS in the Turkish population...
  93. doi IL-1 beta induces urokinase-plasminogen activator expression and cell migration through PKC alpha, JNK1/2, and NF-kappaB in A549 cells
    Ching Yi Cheng
    Department of Pharmacology, Chang Gung University, Tao Yuan, Taiwan
    J Cell Physiol 219:183-93. 2009
    ....
  94. ncbi Interleukin-1 receptor antagonist gene VNTR polymorphism is associated with coronary artery disease
    Ahmet Arman
    Departamento de Cardiologia, Faculdade de Engenharia, Universidade Marmara, Istambul, Turquia
    Arq Bras Cardiol 91:293-8. 2008
    ..Atherosclerosis is an inflammatory disease. Cytokine gene variations such as those associated with the IL1 family are involved in the pathogenesis of atherosclerosis...
  95. ncbi Interleukin 1 gene cluster, myocardial infarction at young age and inflammatory response of human mononuclear cells
    Maria Carmela Latella
    John Paul II Center for High Technology Research and Education in Biomedical Sciences, Catholic University, Campobasso, Italy
    Immunol Invest 38:203-19. 2009
    ..No association was found between block "B" IL-1B haplotypes or IL-1A and IL-RA polymorphisms and risk of MI. IL-1B haplotypes influence the inflammatory response of human mononuclear cells to LPS and affect the risk of MI at young age...
  96. doi Lack of association between IL-1 and IL-6 gene polymorphisms and myocardial infarction in Turkish population
    A Coker
    The Faculty of Science and Letters, The Department of Molecular Biology and Genetics, Atakoy Campus, Istanbul Kultur University, Istanbul, Turkey
    Int J Immunogenet 38:201-8. 2011
    ..Thus, IL-1 and IL-6 single nucleotide polymorphisms may not be a risk factor for susceptibility to MI in Turkish population...
  97. doi Effect of TNF-α and IL-1β genetic variants on the development of myocardial infarction in Turkish population
    Umit Zeybek
    Institute for Experimental Medicine, Department of Molecular Medicine, Istanbul University, Capa, 34390 Istanbul, Turkey
    Mol Biol Rep 38:5453-7. 2011
    Tumor necrosis factor-alpha (TNF-α) and interleukin 1 beta (IL-1β) genetic variants which resulting in TNF-α and IL-1 overproduction may increase susceptibility to autoimmune diseases such as atherosclerosis...
  98. doi Lack of association of interleukin-1 gene cluster polymorphisms with angiographically documented coronary artery disease: demonstration of association with hypertension in the Polish population
    Jarosław Goracy
    Clinic of Cardiology, Pomeranian Medical University, Szczecin, Poland
    Arch Med Res 42:426-32. 2011
    ..multivessel disease, MVD) and hypertension...
  99. doi The associations between interleukin-1 polymorphisms and susceptibility to ankylosing spondylitis: a meta-analysis
    Wu In Lea
    Korea University College of Medicine, 26 1, Anam Dong 5 Ga, Seongbuk gu, Seoul 136 705, Korea
    Joint Bone Spine 79:370-4. 2012
    ..The aim of this study was to determine whether polymorphisms of interleukin-1 (IL-1) confer susceptibility to ankylosing spondylitis (AS)...
  100. ncbi Interleukin 1alpha, interleukin 1beta and interleukin 1 receptor gene polymorphisms in psoriatic arthritis
    J S Ravindran
    Royal National Hospital for Rheumatic Diseases, Bath, UK
    Rheumatology (Oxford) 43:22-6. 2004
    ..To investigate polymorphisms of interleukin (IL) 1alpha, IL-1beta and IL-1 receptor R1 genes in patients with psoriatic arthritis (PsA), their relationship to the age of onset of psoriasis and the pattern of joint involvement...
  101. ncbi Identification of alpha 2-macroglobulin as a cytokine binding plasma protein. Binding of interleukin-1 beta to "F" alpha 2-macroglobulin
    W Borth
    Institute of Immunology, University of Vienna, Austria
    J Biol Chem 264:5818-25. 1989
    ....

Research Grants76

  1. ROLE OF MACROPHAGE SIALOPHORIN (CD43) IN HIV DEFENSE
    EILEEN REMOLD O DONNELL; Fiscal Year: 1992
    ..Finally, we will determine whether CD43 plays a role in the binding and uptake of HIV by monocyte...
  2. AIDS DEMENTIA--MOLECULAR AND CELLULAR MECHANISMS
    Floyd Bloom; Fiscal Year: 2000
    ..In addition, these studies may illuminate other unexplained aspects of fundamental neuronal-glial-immune system interaction, the nature of brain resident microglia, and the basis for neuropsychiatric disorders of unknown origin. ..
  3. MOLECULAR BASIS FOR DRUG INDUCED CARDIOTOXICITY IN AIDS
    CRAIG CLARKSON; Fiscal Year: 2001
    ....
  4. A MACROPHAGE PROTEIN IN COLON TUMORIGENESIS
    Aniruddha Ganguly; Fiscal Year: 2001
    ..abstract_text> ..
  5. ACCESSORY CELL ACTIVATION OF THE IMMUNE RESPONSE
    PHILIP AURON; Fiscal Year: 2004
    ..abstract_text> ..
  6. Genetic susceptibility to gastric cancer in Latin America
    Eduardo M Tarazona-Santos; Fiscal Year: 2011
    ..By performing the study in Lima and Rio de Janeiro, we address the key issue of replication of genetic association studies. ..
  7. Neural Plasticity and Inflammatory Pain
    Clifford J Woolf; Fiscal Year: 2010
    ..that peripheral and central sensitization are both driven by the inflammatory mediators PGE2, bradykinin and IL1 beta. We propose that the transient receptor potential channel TRPA1 is a receptor-operated channel for PGE2, BK and ..
  8. Emilio B Gonzalez; Fiscal Year: 2014
    ..These studies may help to devise new more specific and less harmful modalities than the anticoagulation or general immunosuppression currently used to treat and prevent thrombosis in patients with aPL Abs. ..
  9. Biobehavioral Genetics of CVD Risk
    Indrani Halder; Fiscal Year: 2010
    ..The ROO phase will involve examining all genes for a comprehensive evaluation of the pathways (End of Abstract) ..
  10. Alcohol, Glial Gene Expression and the Heat Shock Pathway
    Neil L Harrison; Fiscal Year: 2010
    ..Microglia are the immune component of the brain and eliminate foreign invaders. Alcohol may alter the activity of all three types of glial cell by changing gene expression, and in doing so may harm nerve cells. ..
  11. Melanie J Scott; Fiscal Year: 2016
    ..Understanding these novel pathways of inflammatory activation and function in individual cell types and organs may help us find new ways to treat and prevent MOF in trauma patients in the future. ..
  12. Development of inlammasome inhibitors to be used as anti-inflammatory agents
    Shyam Biswal; Fiscal Year: 2013
    ..Successful completion of the proposed study will yield novel compounds that inhibit the inflammasome in cell-based systems. ..
  13. Edith Porter; Fiscal Year: 2014
    ..Last, not least, this research may lead to the discovery of novel virulence factors of pathogenic microbes that circumvent host defenses mediated by antimicrobial lipids in the respiratory tract and on other mucosal surfaces. ..
  14. ARIC ANDREW PRATHER; Fiscal Year: 2016
    ....
  15. ENDOTHELIAL GB3 SPECIES INVOLVED IN HUS PATHOGENESIS
    DAVID NEWBURG; Fiscal Year: 2003
    ..The detailed description of the expression of these endothelial cell Stx receptors will potentially lead to development of precisely targeted therapies that can reduce Stx toxicity and these devastating effects of HUS/TTP. ..
  16. Genetic Control of IL-1 and its Role in Inflammatory Arthritis
    Alyssa K Johnsen; Fiscal Year: 2010
    ..In addition, given the pleiotropic effects of IL-1 in inflammation, the results can be broadly applied to other disease states including other autoimmune conditions, infection, and cancer. ..
  17. CYTOKINE INDUCTION BY A 48 KD MYCOPLASMA GENE PRODUCT
    Robert Hall; Fiscal Year: 1999
    ....
  18. H.pylori, genes and esophageal adenocarcinoma
    Geoffrey Liu; Fiscal Year: 2005
    ..abstract_text> ..
  19. IL-4 Potentiates T Cell Death in Autoimmune Arthritis
    Jian Zhang; Fiscal Year: 2006
    ..studies indicate that IL-4 can promote AICD by down regulating expression of Fas-associated death domain-like IL1 beta-converting enzyme inhibitory protein (FLIP) and up regulating FasL expression, and these effects are achieved via ..
  20. Reactivation Tuberculosis in A/J
    Chinnaswamy Jagannath; Fiscal Year: 2005
    ..These studies are anticipated to enhance our understanding on putative mechanisms that precede the reactivation of tuberculosis in the lungs of mice and ultimately help us to develop better strategies to prevent tuberculosis in man. ..
  21. Omega-3 Fatty Acids Effect on Wound Healing
    JODI PELHAM; Fiscal Year: 2006
    ..It is hypothesized that subjects receiving the EPA and DHA supplements will have significantly lower cytokine levels and a slower healing rate. ..
  22. Excess TGF beta in neonatal lung injury and repair
    David Warburton; Fiscal Year: 2004
    ..abstract_text> ..
  23. Interleukin-1 and Memory Loss in Aging
    Carmelina Gemma; Fiscal Year: 2006
    ....
  24. CYTOKINE-TO-BRAIN COMMUNICATION--ROLE OF THE VAGUS
    Linda Watkins; Fiscal Year: 2002
    ..Additionally, the released time will foster further professional growth by yielding coherent blocks of time for concentrating on research and review projects. ..
  25. Creatine: Is It a Body Builder for Cancer Patients?
    Aminah Jatoi; Fiscal Year: 2004
    ..obtain longitudinal toxicity and quality of life data on this same cohort of 50 patients and will make direct comparisons between treatment arms on toxicity incidence and severity and on maximal quality of life scores ..
  26. Mechanisms and Therapeutics in Cancer Anorexia/Cachexia
    Aminah Jatoi; Fiscal Year: 2004
    ..This K23 grant application will serve as a springboard to allow her to delve into the pathophysiology of this syndrome and to develop into an independent clinical investigator. ..
  27. Neuropeptide Y for Cancer-Associated Anorexia
    Aminah Jatoi; Fiscal Year: 2003
    ..These two pilot studies will allow us to lay the groundwork for such larger trials. Our ultimate goal is to help cancer patients who suffer from anorexia. ..
  28. Hyperhomocysteinemia in Alzheimer's Disease
    Ramon Diaz Arrastia; Fiscal Year: 2003
    ..Each of these specific aims is essential to rationally design a large multicenter trial to determine whether polyvitamin therapy lowers AD risk. ..
  29. Gene Polymorphism & Treatment-Symptoms in Lung Cancer
    Cielito Reyes Gibby; Fiscal Year: 2008
    ..abstract_text> ..
  30. Symptom Measurement and Interrelationships During Chemotherapy for Ovarian Cancer
    Heather Jim; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  31. Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory Functions
    MICHAEL L CAMILLERI; Fiscal Year: 2010
    ..These actions may be relevant to develop new treatments for IBS. The studies will also provide further understanding of the potential of medications like medical marijuana on stomach function that may be relevant to appetite control. ..
  32. Characterizing temporal dynamics of spontaneous pain
    APKAR APKARIAN; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  33. Candidate genetic polymorphisms/ HIV-associated dementia
    Ramon Diaz Arrastia; Fiscal Year: 2002
    ..These studies, is if successful, will provide genetic evidence for a role of specific inflammatory mediators in HAD, and may identify novel targets for therapeutic intervention. ..
  34. Role of Flip Macrophages
    Richard Pope; Fiscal Year: 2007
    ..These studies will provide insights into mechanisms that contribute to the pathogenesis of RA and potentially the development of new therapeutic strategies. ..
  35. Advanced Reproductive Age and Environmental Health
    Stephanie Engel; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  36. IN VIVO TREATMENT OF EAE WITH ANTI I-A ANTIBODIES
    Lawrence Steinman; Fiscal Year: 2001
    ..Aim 5 is to assess the possibility of using DNA vaccination against TCR Vb for treatment of EAE. It is hoped that these studies will provide the basis for future clinical trials in MS patients. ..
  37. PEPTIDE MEDIATED IMMUNOTHERAPY FOR AUTOIMMUNE DISEASE
    Lawrence Steinman; Fiscal Year: 2003
    ..This work with APL may be applicable not only to MS, but to other autoimmune diseases including juvenile diabetes, rheumatoid arthritis, and inflammatory bowel disease. ..
  38. Neuronal transport of gp120
    Italo Mocchetti; Fiscal Year: 2005
    ..abstract_text> ..
  39. PERINATAL ESTROGEN, OXIDATIVE DAMAGES & UTERINE LESIONS
    Deodutta Roy; Fiscal Year: 2005
    ....
  40. Fine Needle Aspiration of Benign Vocal Fold Lesions
    Susan Thibeault; Fiscal Year: 2004
    ..abstract_text> ..
  41. Regulation of Prostaglandin E Synthases in Parturition
    William Ackerman; Fiscal Year: 2004
    ..We hope to support the hypothesis that, as in other systems, microsomal PGES is functionally linked to COX-2 in the generation of uterotonic POE2. ..
  42. Dietary supplementation with glucan enhances immune fn
    David Williams; Fiscal Year: 2002
    ..At the successful conclusion of this research e will have established what, if any, effect dietary supplementation with glucan has on modulating immunocompetence arid whether oral glucans will increase resistance to infectious diseases. ..
  43. International Conference on Advances in Laryngeal Biophysiology
    Susan Thibeault; Fiscal Year: 2008
    ..The multifactorial nature of voice disorders necessitates study for a comprehensive understanding of the disease mechanisms for optimal treatment success. [unreadable] [unreadable] [unreadable] [unreadable]..
  44. Genetic factors in outcome from traumatic brain injury
    Ramon Diaz Arrastia; Fiscal Year: 2008
    ..These studies may provide genetic evidence for a role of specific genes in tissue response after TBI, and may identify novel targets for therapeutic intervention. ..
  45. Comprehensive Research Training for Oral Health Sciences
    Frank Scannapieco; Fiscal Year: 2008
    ..Name Organization Frank A. Scannapieco University at Buffalo/Oral Biology Libuse Bobek University at Buffalo/Oral Biology Rosemary Dziak University at Buffalo/Oral Biology in the format shown below. Role on ..
  46. Galanin and GalR2 Receptors in Antidepressant Treatments
    Tamas Bartfai; Fiscal Year: 2009
    ..The planned work will deepen our knowledge of the galanin/5-HT system in the DRN and its contribution to the effects of antidepressant treatments. ..
  47. Phytochemical Treatments for Vocal Fold Scar
    Bernard Rousseau; Fiscal Year: 2004
    ..abstract_text> ..
  48. Regulation of airway epithelial repair
    Steven R White; Fiscal Year: 2010
    ....
  49. Immunoglobulin Allotypes in Hepatitis C Virus Infection
    JANARDAN PANDEY; Fiscal Year: 2008
    ..Results of this investigation will advance our understanding of the role of host genetic factors in clearance and persistence of hepatitis C virus infection. ..
  50. CYTOKINES, NEURODEGENERATION AND DOWN'S SYNDROME
    Sue Griffin; Fiscal Year: 2004
    ..Accomplishment of our aims will elucidate the pathogenic mechanisms underlying the cognitive decline apparent at middle age in Down's patients and provide targets for possible therapeutic intervention. ..
  51. CORTICOSTEROID INDUCED APOPTOSIS IN AIRWAY EPITHELIUM
    Steven White; Fiscal Year: 2002
    ..These data would help lead to new therapeutic ideas and modalities in the treatment of asthma to suppress inflammation while preventing mucosal damage. ..
  52. Large Scale Images of Gene Transcription in MS and EAE
    Lawrence Steinman; Fiscal Year: 2004
    ..The discovery of the role of osteopontin, first identified in large scale profiles, exemplifies how this approach may help us to understand MS and to develop new therapies. ..
  53. FOUR-CORNERS BREAST AND ENDOMETRIAL CANCER STUDY
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2003
    ..C-peptide, glycosylated hemoglobin, IGF-1, and IGFBP3 will be evaluated with respect to breast and endometrial cancer in a subset of women. ..
  54. IL-1 and IL-1ra Stimulation of S aureus Replication
    SIVADASAN KANANGAT; Fiscal Year: 2003
    ..A better understanding of how bacteria such as S. aureus use IL-1 family of cytokines to replicate and defeat the host defense is highly relevant to the study of septic arthritis. ..
  55. ANTI-HIV-1 ACTIVITY OF MANNAN-BINDING LECTIN
    Gregory Spear; Fiscal Year: 2003
    ..3. Utilize inhibitors of glycosylation to enhance biological effects of MBL. Exarnine the interaction of MBL with anti-viral antibodies in mediating anti-viral effects. Deterrnine the interaction of HIV-1 with MBL in vivo. ..
  56. Mechanisms of Radiation Induced Fatigue in Cancer
    Julienne Bower; Fiscal Year: 2006
    ..Together with a targeted program of didactic instruction, this project will prepare the candidate to become a fully independent behavioral scientist in the field of cancer prevention and control research. ..
  57. A Genetic Model of Uveitis
    TAMMY MARTIN; Fiscal Year: 2006
    ..Both transgenic mice and transgenic mice crossed with NOD2 knock-out mice will be studied. [unreadable] [unreadable] [unreadable]..
  58. Gene Expression in Chronic and Aggressive Periodontitis
    Panos Papapanou; Fiscal Year: 2006
    ..Ultimately, a pathobiology-based classification of periodontitis will facilitate correct diagnosis and targeted, efficient therapeutic prevention and intervention strategies. [unreadable] [unreadable]..
  59. Antidepressants and Fibroblast Growth Factor
    Italo Mocchetti; Fiscal Year: 2006
    ..Data from this proposal may help elucidate the therapeutic efficacy of antidepressants in affective disorders. [unreadable] [unreadable]..
  60. Growth Factors and Colon Cancer
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
    ..This study builds on a unique existing resource to study genetic and environmental associations with colorectal cancer. It will provide insight into colon cancer etiology and therefore avenues to disease prevention. ..
  61. A PROSPECTIVE STUDY OF ALASKA NATIVES & AMERICAN INDIANS
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
    ..The AIAN cohort will serve as a resource to enhance research and training activities of AIAN students interested in health research, health education, and general public health. ..
  62. The role of Mcl-1 in the macrophages and RA
    Richard Pope; Fiscal Year: 2007
    ..RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page.................................................................................................................................................. 1 Description, ..
  63. Cytokine Modulation by Follicle-Stimulating Hormone
    Joseph Cannon; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  64. Neuronal Apoptosis Induced by DNA Damage
    Italo Mocchetti; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  65. Function of galanin receptor subtypes in the hippocampus
    Tamas Bartfai; Fiscal Year: 2006
    ..Also, because galanin has been shown to have anti-epileptic actions, understanding how this peptide regulates seizures could have clinical applications in the treatment of epilepsy. ..
  66. Sleep Disruption in New Parents: An intervention Trial
    Kathryn Lee; Fiscal Year: 2006
    ..More generalizable results from this targeted sample will be used to develop an educational intervention package for distribution to all adults preparing for parenthood. [unreadable] [unreadable] [unreadable]..
  67. Quantification of Host Markers in GCF Using CBIB
    Ricardo Teles; Fiscal Year: 2007
    ..Moreover, this methodology is at the forefront of new approaches in proteomics, and carries enormous promise for translational applications in the near future. [unreadable] [unreadable]..
  68. Biomarkers of Insomnia and Fatigue in HIV/AIDS
    Kathryn Lee; Fiscal Year: 2007
    ..It is hypothesized that the set of biomarkers that best predict the onset of initiation insomnia may differ from the variables that predict maintenance insomnia or daytime quality of life measures. ..
  69. Mechanisms of u-PAR-Mediated Lung Fibroblast Motility
    Mitchell Olman; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  70. Cortical Dynamics for Pain Perception in Behaving Rats
    APKAR APKARIAN; Fiscal Year: 2005
    ..abstract_text> ..
  71. Safety & effectiveness of HA hydrogels in immortalized vocal fold fibroblast cell
    Susan Thibeault; Fiscal Year: 2007
    ..Efforts from this R21 will provide imminent directions for an R01 focusing on human clinical trials for treatment of ECM disorders. [unreadable] [unreadable] [unreadable]..
  72. Metabolomics and metabolic compartmentation in the brain
    Julian Griffin; Fiscal Year: 2006
    ..To correlate NMR observable metabolite changes with transcriptional changes. Our data will provide proof-of principle for this methodology, and establish a means for exploring other neurolodegenerative disorders. ..
  73. DIET AND SOMATIC MUTATIONS IN COLON CANCER
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2007
    ..e. p53, K-ras, and microsatellite instability). Differences in colon and rectal tumors will be compared. Additionally data from rectal tumors will be combined with that from colon tumors to define disease pathways. ..